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Conserved domains on  [gi|672074384|ref|XP_008767855|]
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ATP-dependent RNA helicase A isoform X2 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DEXHc_DHX9 cd17972
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ...
 116-349 3.56e-154

DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ATP-dependent RNA helicase A or RHA and leukophysin or LKP) plays an important role in many cellular processes, including regulation of DNA replication, transcription, translation, microRNA biogenesis, RNA processing and transport, and maintenance of genomic stability. DHX9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


:

Pssm-ID: 350730 [Multi-domain]  Cd Length: 234  Bit Score: 459.69  E-value: 3.56e-154
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  116 VPWSPPQSNWNPWTSSNIDEGPLAYASTEQISMDLKNELAYQMEQDHNLQSVLQERELLPVKKFEAEILEAISQNSVVII 195
Cdd:cd17972     1 VPWSPPQSNWNPWTSSNIDEGPLAFATPEQISMDLKNELMYQREQDHNLQQILQERELLPVKKFREEILEAISNNPVVII 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  196 RGATGCGKTTQVPQYILDDFIQNDRAAECNIVVTQPRRISAVAVAERVAYERGEEPGKSCGYSVRFESILPRPHASIMFC 275
Cdd:cd17972    81 RGATGCGKTTQVPQYILDDFIQNDRAAECNIVVTQPRRISAVSVAERVAFERGEEVGKSCGYSVRFESVLPRPHASILFC 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 672074384  276 TVGVLLRKLEAGIRGISHVIVDEIHERDINTDFLLVVLRDVVLAYPEVRIVLMSATIDTTMFCEYFFNCPIIEV 349
Cdd:cd17972   161 TVGVLLRKLEAGIRGISHVIVDEIHERDINTDFLLVVLRDVVQAYPDLRVILMSATIDTSMFCEYFFNCPVIEV 234
HrpA super family cl34328
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
174-672 1.88e-107

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG1643:

Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 357.08  E-value: 1.88e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  174 LPVKKFEAEILEAISQNSVVIIRGATGCGKTTQVPQYILDdfiqNDRAAECNIVVTQPRRISAVAVAERVAYERGEEPGK 253
Cdd:COG1643    10 LPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALLE----LGWGAGGRIGMLEPRRLAARAAAERMAEELGEPVGE 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  254 SCGYSVRFESilpR--PHASIMFCTVGVLLRKLEA--GIRGISHVIVDEIHERDINTDFLLvvlrdvvlAY--------- 320
Cdd:COG1643    86 TVGYRVRFED---KvsAATRIEVVTEGILLRELQRdpELEGVDTVIFDEFHERSLNADLLL--------ALlldlqpalr 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  321 PEVRIVLMSATIDTTMFCEYFFNCPIIEVYGRTFPVQeyfledciqmTQFIPPPKDKKkkdkeddggedddancnlicgd 400
Cdd:COG1643   155 PDLKLLVMSATLDAERFARLLGDAPVIESSGRTYPVE----------VRYRPLPADER---------------------- 202

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  401 eygpetklsmsqlneketpfELIEALLKYIETL--NVPGAVLVFLPGWNLIYTMQKHLENnsHFGSHrYQILPLHSQIPR 478
Cdd:COG1643   203 --------------------DLEDAVADAVREAlaEEPGDILVFLPGEREIRRTAEALRG--RLPPD-TEILPLYGRLSA 259

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  479 EEQRKVFDPVPDGVTKVILSTNIAETSITINDVVYVIDSCKQKVKLFTAHNNMTNYATVWASKTNLEQRKGRAGRVRPGF 558
Cdd:COG1643   260 AEQDRAFAPAPHGRRRIVLATNIAETSLTVPGIRYVIDSGLARIPRYDPRSGVTRLPTERISQASANQRAGRAGRLAPGI 339

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  559 CFHLCSRARFDRLETHMTPEMFRTPLHEIALSIKLLRLGGIGQFlaKAIEPPPLDAVIEAEHTLRELDALDANDELTPLG 638
Cdd:COG1643   340 CYRLWSEEDFARRPAFTDPEILRADLASLILELAAWGLGDPEDL--PFLDPPPARAIADARALLQELGALDADGRLTPLG 417

                         490       500       510
                  ....*....|....*....|....*....|....
gi 672074384  639 RILAKLPIEPRFGKMMIMGCIFYVGDAVCTISAA 672
Cdd:COG1643   418 RALARLPLDPRLARMLLAAAELGCLREAAILAAL 451
OB_NTP_bind pfam07717
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ...
 780-859 3.55e-19

Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.


:

Pssm-ID: 400182 [Multi-domain]  Cd Length: 82  Bit Score: 83.07  E-value: 3.55e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384   780 LLAFGVYPNVCYHKEKRKILTT--EGRNALIHKSSVNCpfssQDMKYPSPFFVFGEKIRTRAISAKGMTLVTPLQLLLFA 857
Cdd:pfam07717    4 ALAAGLYPNVARRDPKGKGYTTlsDNQRVFIHPSSVLF----NEKTFPPEWVVYQELVETTKVYIRTVTAISPEWLLLFA 79


                   ..
gi 672074384   858 SK 859
Cdd:pfam07717   80 PH 81
DSRM_SF super family cl00054
double-stranded RNA binding motif (DSRM) superfamily; DSRM (also known as dsRBM) is a 65-70 ...
 1-38 3.78e-18

double-stranded RNA binding motif (DSRM) superfamily; DSRM (also known as dsRBM) is a 65-70 amino acid domain that adopts an alpha-beta-beta-beta-alpha fold. It is not sequence specific, but highly specific for double-stranded RNAs (dsRNAs) of various origin and structure. The DSRM domains are found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila Staufen protein, E. coli RNase III, RNase H1, and dsRNA dependent adenosine deaminases. They are involved in numerous cellular mechanisms ranging from localization and transport of messenger RNAs, through maturation and degradation of RNAs, to viral response and signal transduction. Some members harbor tandem DSRMs that act in small RNA biogenesis.


The actual alignment was detected with superfamily member cd19855:

Pssm-ID: 444671  Cd Length: 75  Bit Score: 79.95  E-value: 3.78e-18
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 672074384    1 MTIYIKQLGRRIFAREHGSNKKLAAQSCALSLVRQLYH 38
Cdd:cd19855    38 LSIFVKQLGKTIYARETGSNKKLASQSCALSLVRQLYH 75
 
Name Accession Description Interval E-value
DEXHc_DHX9 cd17972
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ...
 116-349 3.56e-154

DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ATP-dependent RNA helicase A or RHA and leukophysin or LKP) plays an important role in many cellular processes, including regulation of DNA replication, transcription, translation, microRNA biogenesis, RNA processing and transport, and maintenance of genomic stability. DHX9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350730 [Multi-domain]  Cd Length: 234  Bit Score: 459.69  E-value: 3.56e-154
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  116 VPWSPPQSNWNPWTSSNIDEGPLAYASTEQISMDLKNELAYQMEQDHNLQSVLQERELLPVKKFEAEILEAISQNSVVII 195
Cdd:cd17972     1 VPWSPPQSNWNPWTSSNIDEGPLAFATPEQISMDLKNELMYQREQDHNLQQILQERELLPVKKFREEILEAISNNPVVII 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  196 RGATGCGKTTQVPQYILDDFIQNDRAAECNIVVTQPRRISAVAVAERVAYERGEEPGKSCGYSVRFESILPRPHASIMFC 275
Cdd:cd17972    81 RGATGCGKTTQVPQYILDDFIQNDRAAECNIVVTQPRRISAVSVAERVAFERGEEVGKSCGYSVRFESVLPRPHASILFC 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 672074384  276 TVGVLLRKLEAGIRGISHVIVDEIHERDINTDFLLVVLRDVVLAYPEVRIVLMSATIDTTMFCEYFFNCPIIEV 349
Cdd:cd17972   161 TVGVLLRKLEAGIRGISHVIVDEIHERDINTDFLLVVLRDVVQAYPDLRVILMSATIDTSMFCEYFFNCPVIEV 234
HrpA COG1643
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
174-672 1.88e-107

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 357.08  E-value: 1.88e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  174 LPVKKFEAEILEAISQNSVVIIRGATGCGKTTQVPQYILDdfiqNDRAAECNIVVTQPRRISAVAVAERVAYERGEEPGK 253
Cdd:COG1643    10 LPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALLE----LGWGAGGRIGMLEPRRLAARAAAERMAEELGEPVGE 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  254 SCGYSVRFESilpR--PHASIMFCTVGVLLRKLEA--GIRGISHVIVDEIHERDINTDFLLvvlrdvvlAY--------- 320
Cdd:COG1643    86 TVGYRVRFED---KvsAATRIEVVTEGILLRELQRdpELEGVDTVIFDEFHERSLNADLLL--------ALlldlqpalr 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  321 PEVRIVLMSATIDTTMFCEYFFNCPIIEVYGRTFPVQeyfledciqmTQFIPPPKDKKkkdkeddggedddancnlicgd 400
Cdd:COG1643   155 PDLKLLVMSATLDAERFARLLGDAPVIESSGRTYPVE----------VRYRPLPADER---------------------- 202

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  401 eygpetklsmsqlneketpfELIEALLKYIETL--NVPGAVLVFLPGWNLIYTMQKHLENnsHFGSHrYQILPLHSQIPR 478
Cdd:COG1643   203 --------------------DLEDAVADAVREAlaEEPGDILVFLPGEREIRRTAEALRG--RLPPD-TEILPLYGRLSA 259

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  479 EEQRKVFDPVPDGVTKVILSTNIAETSITINDVVYVIDSCKQKVKLFTAHNNMTNYATVWASKTNLEQRKGRAGRVRPGF 558
Cdd:COG1643   260 AEQDRAFAPAPHGRRRIVLATNIAETSLTVPGIRYVIDSGLARIPRYDPRSGVTRLPTERISQASANQRAGRAGRLAPGI 339

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  559 CFHLCSRARFDRLETHMTPEMFRTPLHEIALSIKLLRLGGIGQFlaKAIEPPPLDAVIEAEHTLRELDALDANDELTPLG 638
Cdd:COG1643   340 CYRLWSEEDFARRPAFTDPEILRADLASLILELAAWGLGDPEDL--PFLDPPPARAIADARALLQELGALDADGRLTPLG 417

                         490       500       510
                  ....*....|....*....|....*....|....
gi 672074384  639 RILAKLPIEPRFGKMMIMGCIFYVGDAVCTISAA 672
Cdd:COG1643   418 RALARLPLDPRLARMLLAAAELGCLREAAILAAL 451
SF2_C_RHA cd18791
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ...
 354-563 1.25e-72

C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350178 [Multi-domain]  Cd Length: 171  Bit Score: 238.59  E-value: 1.25e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  354 FPVQEYFLEDCIQMTQfipppkdkkkkdkeddggedddancnlicgdeygpetklsMSQLNEKETPFELIEALLKYIETL 433
Cdd:cd18791     1 FPVEVYYLEDILELLG----------------------------------------ISSEKEDPDYVDAAVRLILQIHRT 40

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  434 NVPGAVLVFLPGWNLIYTMQKHLENNSHFGS-HRYQILPLHSQIPREEQRKVFDPVPDGVTKVILSTNIAETSITINDVV 512
Cdd:cd18791    41 EEPGDILVFLPGQEEIERLCELLREELLSPDlGKLLVLPLHSSLPPEEQQRVFEPPPPGVRKVVLATNIAETSITIPGVV 120

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 672074384  513 YVIDSCKQKVKLFTAHNNMTNYATVWASKTNLEQRKGRAGRVRPGFCFHLC 563
Cdd:cd18791   121 YVIDSGLVKEKVYDPRTGLSSLVTVWISKASAEQRAGRAGRTRPGKCYRLY 171
DEAH_box_HrpB TIGR01970
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but ...
 174-657 6.00e-71

ATP-dependent helicase HrpB; This model represents HrpB, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria, but also in a few species of other lineages. The member from Rhizobium meliloti has been designated HelO. HrpB is typically about 800 residues in length, while its paralog HrpA (TIGR01967), also uncharacterized, is about 1300 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 273901 [Multi-domain]  Cd Length: 819  Bit Score: 254.31  E-value: 6.00e-71
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384   174 LPVKKFEAEILEAISQNSVVIIRGATGCGKTTQVPQYILDDFIQNDRaaecnIVVTQPRRISAVAVAERVAYERGEEPGK 253
Cdd:TIGR01970    1 LPIHAVLPALRDALAAHPQVVLEAPPGAGKSTAVPLALLDAPGIGGK-----IIMLEPRRLAARSAAQRLASQLGEAVGQ 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384   254 SCGYSVRFESILPrPHASIMFCTVGVLLRKLEA--GIRGISHVIVDEIHERDINTDFLLVVLRDVVLAYPE-VRIVLMSA 330
Cdd:TIGR01970   76 TVGYRVRGENKVS-RRTRLEVVTEGILTRMIQDdpELDGVGALIFDEFHERSLDADLGLALALDVQSSLREdLKILAMSA 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384   331 TIDTTMFCEYFFNCPIIEVYGRTFPVQeyfledciqmTQFIPPPkdkkkkdkeddggedddancnlicGDEYgpetklsm 410
Cdd:TIGR01970  155 TLDGERLSSLLPDAPVVESEGRSFPVE----------IRYLPLR------------------------GDQR-------- 192

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384   411 sqlneketpfeLIEALLKYIETL--NVPGAVLVFLPGWNLIYTMQKHLenNSHFGShRYQILPLHSQIPREEQRKVFDPV 488
Cdd:TIGR01970  193 -----------LEDAVSRAVEHAlaSETGSILVFLPGQAEIRRVQEQL--AERLDS-DVLICPLYGELSLAAQDRAIKPD 258

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384   489 PDGVTKVILSTNIAETSITINDVVYVIDSCKQKVKLFTAHNNMTNYATVWASKTNLEQRKGRAGRVRPGFCFHLCSRARF 568
Cdd:TIGR01970  259 PQGRRKVVLATNIAETSLTIEGIRVVIDSGLARVARFDPKTGITRLETVRISQASATQRAGRAGRLEPGVCYRLWSEEQH 338

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384   569 DRLETHMTPEMFRTPLHEIALsiKLLRLGGIGQFLAKAIEPPPLDAVIEAEHTLRELDALDANDELTPLGRILAKLPIEP 648
Cdd:TIGR01970  339 QRLPAQDEPEILQADLSGLAL--ELAQWGAKDPSDLRWLDAPPSVALAAARQLLQRLGALDAQGRLTAHGKAMAALGCHP 416


                   ....*....
gi 672074384   649 RFGKMMIMG 657
Cdd:TIGR01970  417 RLAAMLLSA 425
PRK11664 PRK11664
ATP-dependent RNA helicase HrpB; Provisional
 173-655 4.13e-63

ATP-dependent RNA helicase HrpB; Provisional


Pssm-ID: 236950 [Multi-domain]  Cd Length: 812  Bit Score: 230.97  E-value: 4.13e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  173 LLPVKKFEAEILEAISQNSVVIIRGATGCGKTTQVPQYILDDFIQNDRaaecnIVVTQPRRISAVAVAERVAYERGEEPG 252
Cdd:PRK11664    3 SLPVAAVLPELLTALKTAPQVLLKAPTGAGKSTWLPLQLLQHGGINGK-----IIMLEPRRLAARNVAQRLAEQLGEKPG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  253 KSCGYSVRFESILPrPHASIMFCTVGVLLRKLE--AGIRGISHVIVDEIHERDINTDFLLVVLRDVVLAYPE-VRIVLMS 329
Cdd:PRK11664   78 ETVGYRMRAESKVG-PNTRLEVVTEGILTRMIQrdPELSGVGLVILDEFHERSLQADLALALLLDVQQGLRDdLKLLIMS 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  330 ATIDTTMFCEYFFNCPIIEVYGRTFPVQeyfledciqmTQFIPppkdkkkkdkeddggedddancnlicgdeygpetkLS 409
Cdd:PRK11664  157 ATLDNDRLQQLLPDAPVIVSEGRSFPVE----------RRYQP-----------------------------------LP 191

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  410 MSQlneketPFEliEALLKYIETL--NVPGAVLVFLPGWNLIYTMQKHLENNshFGSHrYQILPLHSQIPREEQRKVFDP 487
Cdd:PRK11664  192 AHQ------RFD--EAVARATAELlrQESGSLLLFLPGVGEIQRVQEQLASR--VASD-VLLCPLYGALSLAEQQKAILP 260

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  488 VPDGVTKVILSTNIAETSITINDVVYVIDSCKQKVKLFTAHNNMTNYATVWASKTNLEQRKGRAGRVRPGFCFHLCSRAR 567
Cdd:PRK11664  261 APAGRRKVVLATNIAETSLTIEGIRLVVDSGLERVARFDPKTGLTRLVTQRISQASMTQRAGRAGRLEPGICLHLYSKEQ 340

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  568 FDRLETHMTPEMFRTPLHEIALSikLLRLG--GIGQFlaKAIEPPPLDAVIEAEHTLRELDALDANDELTPLGRILAKLP 645
Cdd:PRK11664  341 AERAAAQSEPEILHSDLSGLLLE--LLQWGchDPAQL--SWLDQPPAAALAAAKRLLQQLGALDGQGRLTARGRKMAALG 416

                         490
                  ....*....|
gi 672074384  646 IEPRFGKMMI 655
Cdd:PRK11664  417 NDPRLAAMLV 426
DEXDc smart00487
DEAD-like helicases superfamily;
168-355 7.12e-22

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 94.87  E-value: 7.12e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384    168 LQERELLPVKKFEAEILEAISQN-SVVIIRGATGCGKTTQVPQYILDDFIQNDRaaeCNIVVTQPRRISAVAVAERVAYE 246
Cdd:smart00487    1 IEKFGFEPLRPYQKEAIEALLSGlRDVILAAPTGSGKTLAALLPALEALKRGKG---GRVLVLVPTRELAEQWAEELKKL 77

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384    247 RGEEPGKSCGYSVRFESI-----LPRPHASIMFCTVGVLLRKLEAG---IRGISHVIVDEIHERDiNTDFLLVVLRDVVL 318
Cdd:smart00487   78 GPSLGLKVVGLYGGDSKReqlrkLESGKTDILVTTPGRLLDLLENDklsLSNVDLVILDEAHRLL-DGGFGDQLEKLLKL 156

                           170       180       190
                    ....*....|....*....|....*....|....*....
gi 672074384    319 AYPEVRIVLMSATI--DTTMFCEYFFNCPIIEVYGRTFP 355
Cdd:smart00487  157 LPKNVQLLLLSATPpeEIENLLELFLNDPVFIDVGFTPL 195
HA2 smart00847
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ...
 624-705 5.33e-21

Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 214852 [Multi-domain]  Cd Length: 82  Bit Score: 88.09  E-value: 5.33e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384    624 ELDALDANDELTPLGRILAKLPIEPRFGKMMIMGCIFYVGDAVCTISAATCFPEPFISE-GKRLGYIHRNFAGNRfSDHV 702
Cdd:smart00847    1 ELGALDDDGRLTPLGRKMAELPLDPRLAKMLLAAAEFGCLDEILTIVAMLSVGDPRPKEkREDADAARRRFADPE-SDHL 79


                    ...
gi 672074384    703 ALL 705
Cdd:smart00847   80 TLL 82
HA2 pfam04408
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ...
 618-704 1.16e-19

Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 461295 [Multi-domain]  Cd Length: 104  Bit Score: 84.98  E-value: 1.16e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384   618 AEHTLRELDALDANDELTPLGRILAKLPIEPRFGKMMIMGCIFYVGDAVCTISAATCFPEPFISEG-------------- 683
Cdd:pfam04408    1 ALELLYYLGALDEDGELTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSVRDPFVQPNfldprsaakaarrr 80

                           90       100
                   ....*....|....*....|....
gi 672074384   684 --KRLGYIHRNFAGNRF-SDHVAL 704
Cdd:pfam04408   81 rrAADEKARAKFARLDLeGDHLTL 104
OB_NTP_bind pfam07717
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ...
 780-859 3.55e-19

Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.


Pssm-ID: 400182 [Multi-domain]  Cd Length: 82  Bit Score: 83.07  E-value: 3.55e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384   780 LLAFGVYPNVCYHKEKRKILTT--EGRNALIHKSSVNCpfssQDMKYPSPFFVFGEKIRTRAISAKGMTLVTPLQLLLFA 857
Cdd:pfam07717    4 ALAAGLYPNVARRDPKGKGYTTlsDNQRVFIHPSSVLF----NEKTFPPEWVVYQELVETTKVYIRTVTAISPEWLLLFA 79


                   ..
gi 672074384   858 SK 859
Cdd:pfam07717   80 PH 81
DSRM_DHX9_rpt2 cd19855
second double-stranded RNA binding motif of DEAH box protein 9 (DHX9) and similar proteins; ...
 1-38 3.78e-18

second double-stranded RNA binding motif of DEAH box protein 9 (DHX9) and similar proteins; DHX9 (EC 3.6.4.13; also known as ATP-dependent RNA helicase A, DExH-box helicase 9 (DDX9), Leukophysin (LKP), nuclear DNA helicase II (NDH II), NDH2, or RNA helicase A) is a multifunctional ATP-dependent nucleic acid helicase that unwinds DNA and RNA in a 3' to 5' direction and plays important roles in many processes, such as DNA replication, transcriptional activation, post-transcriptional RNA regulation, mRNA translation and RNA-mediated gene silencing. It contains two double-stranded RNA binding motifs (DSRMs) at the N-terminal region. This model corresponds to the second motif. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure.


Pssm-ID: 380684  Cd Length: 75  Bit Score: 79.95  E-value: 3.78e-18
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 672074384    1 MTIYIKQLGRRIFAREHGSNKKLAAQSCALSLVRQLYH 38
Cdd:cd19855    38 LSIFVKQLGKTIYARETGSNKKLASQSCALSLVRQLYH 75
DEAD pfam00270
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ...
 181-335 2.14e-06

DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.


Pssm-ID: 425570 [Multi-domain]  Cd Length: 165  Bit Score: 49.16  E-value: 2.14e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384   181 AEILEAISQNSVVIIRGATGCGKTT--QVPqyILDDFIQNDRAAECnIVVTqPRRISAVAVAERVayergEEPGKSCGYS 258
Cdd:pfam00270    5 AEAIPAILEGRDVLVQAPTGSGKTLafLLP--ALEALDKLDNGPQA-LVLA-PTRELAEQIYEEL-----KKLGKGLGLK 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384   259 VRFE----------SILPRPHasIMFCTVGVLLR--KLEAGIRGISHVIVDEIHeRDINTDFLLVVLRDVVLAYPEVRIV 326
Cdd:pfam00270   76 VASLlggdsrkeqlEKLKGPD--ILVGTPGRLLDllQERKLLKNLKLLVLDEAH-RLLDMGFGPDLEEILRRLPKKRQIL 152


                   ....*....
gi 672074384   327 LMSATIDTT 335
Cdd:pfam00270  153 LLSATLPRN 161
 
Name Accession Description Interval E-value
DEXHc_DHX9 cd17972
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ...
 116-349 3.56e-154

DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ATP-dependent RNA helicase A or RHA and leukophysin or LKP) plays an important role in many cellular processes, including regulation of DNA replication, transcription, translation, microRNA biogenesis, RNA processing and transport, and maintenance of genomic stability. DHX9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350730 [Multi-domain]  Cd Length: 234  Bit Score: 459.69  E-value: 3.56e-154
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  116 VPWSPPQSNWNPWTSSNIDEGPLAYASTEQISMDLKNELAYQMEQDHNLQSVLQERELLPVKKFEAEILEAISQNSVVII 195
Cdd:cd17972     1 VPWSPPQSNWNPWTSSNIDEGPLAFATPEQISMDLKNELMYQREQDHNLQQILQERELLPVKKFREEILEAISNNPVVII 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  196 RGATGCGKTTQVPQYILDDFIQNDRAAECNIVVTQPRRISAVAVAERVAYERGEEPGKSCGYSVRFESILPRPHASIMFC 275
Cdd:cd17972    81 RGATGCGKTTQVPQYILDDFIQNDRAAECNIVVTQPRRISAVSVAERVAFERGEEVGKSCGYSVRFESVLPRPHASILFC 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 672074384  276 TVGVLLRKLEAGIRGISHVIVDEIHERDINTDFLLVVLRDVVLAYPEVRIVLMSATIDTTMFCEYFFNCPIIEV 349
Cdd:cd17972   161 TVGVLLRKLEAGIRGISHVIVDEIHERDINTDFLLVVLRDVVQAYPDLRVILMSATIDTSMFCEYFFNCPVIEV 234
HrpA COG1643
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
174-672 1.88e-107

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 357.08  E-value: 1.88e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  174 LPVKKFEAEILEAISQNSVVIIRGATGCGKTTQVPQYILDdfiqNDRAAECNIVVTQPRRISAVAVAERVAYERGEEPGK 253
Cdd:COG1643    10 LPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALLE----LGWGAGGRIGMLEPRRLAARAAAERMAEELGEPVGE 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  254 SCGYSVRFESilpR--PHASIMFCTVGVLLRKLEA--GIRGISHVIVDEIHERDINTDFLLvvlrdvvlAY--------- 320
Cdd:COG1643    86 TVGYRVRFED---KvsAATRIEVVTEGILLRELQRdpELEGVDTVIFDEFHERSLNADLLL--------ALlldlqpalr 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  321 PEVRIVLMSATIDTTMFCEYFFNCPIIEVYGRTFPVQeyfledciqmTQFIPPPKDKKkkdkeddggedddancnlicgd 400
Cdd:COG1643   155 PDLKLLVMSATLDAERFARLLGDAPVIESSGRTYPVE----------VRYRPLPADER---------------------- 202

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  401 eygpetklsmsqlneketpfELIEALLKYIETL--NVPGAVLVFLPGWNLIYTMQKHLENnsHFGSHrYQILPLHSQIPR 478
Cdd:COG1643   203 --------------------DLEDAVADAVREAlaEEPGDILVFLPGEREIRRTAEALRG--RLPPD-TEILPLYGRLSA 259

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  479 EEQRKVFDPVPDGVTKVILSTNIAETSITINDVVYVIDSCKQKVKLFTAHNNMTNYATVWASKTNLEQRKGRAGRVRPGF 558
Cdd:COG1643   260 AEQDRAFAPAPHGRRRIVLATNIAETSLTVPGIRYVIDSGLARIPRYDPRSGVTRLPTERISQASANQRAGRAGRLAPGI 339

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  559 CFHLCSRARFDRLETHMTPEMFRTPLHEIALSIKLLRLGGIGQFlaKAIEPPPLDAVIEAEHTLRELDALDANDELTPLG 638
Cdd:COG1643   340 CYRLWSEEDFARRPAFTDPEILRADLASLILELAAWGLGDPEDL--PFLDPPPARAIADARALLQELGALDADGRLTPLG 417

                         490       500       510
                  ....*....|....*....|....*....|....
gi 672074384  639 RILAKLPIEPRFGKMMIMGCIFYVGDAVCTISAA 672
Cdd:COG1643   418 RALARLPLDPRLARMLLAAAELGCLREAAILAAL 451
SF2_C_RHA cd18791
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ...
 354-563 1.25e-72

C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350178 [Multi-domain]  Cd Length: 171  Bit Score: 238.59  E-value: 1.25e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  354 FPVQEYFLEDCIQMTQfipppkdkkkkdkeddggedddancnlicgdeygpetklsMSQLNEKETPFELIEALLKYIETL 433
Cdd:cd18791     1 FPVEVYYLEDILELLG----------------------------------------ISSEKEDPDYVDAAVRLILQIHRT 40

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  434 NVPGAVLVFLPGWNLIYTMQKHLENNSHFGS-HRYQILPLHSQIPREEQRKVFDPVPDGVTKVILSTNIAETSITINDVV 512
Cdd:cd18791    41 EEPGDILVFLPGQEEIERLCELLREELLSPDlGKLLVLPLHSSLPPEEQQRVFEPPPPGVRKVVLATNIAETSITIPGVV 120

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 672074384  513 YVIDSCKQKVKLFTAHNNMTNYATVWASKTNLEQRKGRAGRVRPGFCFHLC 563
Cdd:cd18791   121 YVIDSGLVKEKVYDPRTGLSSLVTVWISKASAEQRAGRAGRTRPGKCYRLY 171
DEXHc_RHA-like cd17917
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) ...
 190-349 3.76e-72

DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438707 [Multi-domain]  Cd Length: 159  Bit Score: 236.97  E-value: 3.76e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  190 NSVVIIRGATGCGKTTQVPQYILDDFIQNDRaaECNIVVTQPRRISAVAVAERVAYERGEEPGKSCGYSVRFESILPrPH 269
Cdd:cd17917     1 NQVVVIVGETGSGKTTQVPQFLLEDGLAKGG--KGRIVCTQPRRIAAISVAERVAEERGEKLGEEVGYQIRFESKTS-SK 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  270 ASIMFCTVGVLLRKLEAG--IRGISHVIVDEIHERDINTDFLLVVLRDVVLAYPEVRIVLMSATIDTTMFCEYFFNCPII 347
Cdd:cd17917    78 TRIKFCTDGILLRELLSDplLSGYSHVILDEAHERSLDTDFLLGLLKDLLRKRPDLKVILMSATLDAEKFSSYFGGAPVI 157


                  ..
gi 672074384  348 EV 349
Cdd:cd17917   158 HI 159
DEAH_box_HrpB TIGR01970
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but ...
 174-657 6.00e-71

ATP-dependent helicase HrpB; This model represents HrpB, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria, but also in a few species of other lineages. The member from Rhizobium meliloti has been designated HelO. HrpB is typically about 800 residues in length, while its paralog HrpA (TIGR01967), also uncharacterized, is about 1300 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 273901 [Multi-domain]  Cd Length: 819  Bit Score: 254.31  E-value: 6.00e-71
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384   174 LPVKKFEAEILEAISQNSVVIIRGATGCGKTTQVPQYILDDFIQNDRaaecnIVVTQPRRISAVAVAERVAYERGEEPGK 253
Cdd:TIGR01970    1 LPIHAVLPALRDALAAHPQVVLEAPPGAGKSTAVPLALLDAPGIGGK-----IIMLEPRRLAARSAAQRLASQLGEAVGQ 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384   254 SCGYSVRFESILPrPHASIMFCTVGVLLRKLEA--GIRGISHVIVDEIHERDINTDFLLVVLRDVVLAYPE-VRIVLMSA 330
Cdd:TIGR01970   76 TVGYRVRGENKVS-RRTRLEVVTEGILTRMIQDdpELDGVGALIFDEFHERSLDADLGLALALDVQSSLREdLKILAMSA 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384   331 TIDTTMFCEYFFNCPIIEVYGRTFPVQeyfledciqmTQFIPPPkdkkkkdkeddggedddancnlicGDEYgpetklsm 410
Cdd:TIGR01970  155 TLDGERLSSLLPDAPVVESEGRSFPVE----------IRYLPLR------------------------GDQR-------- 192

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384   411 sqlneketpfeLIEALLKYIETL--NVPGAVLVFLPGWNLIYTMQKHLenNSHFGShRYQILPLHSQIPREEQRKVFDPV 488
Cdd:TIGR01970  193 -----------LEDAVSRAVEHAlaSETGSILVFLPGQAEIRRVQEQL--AERLDS-DVLICPLYGELSLAAQDRAIKPD 258

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384   489 PDGVTKVILSTNIAETSITINDVVYVIDSCKQKVKLFTAHNNMTNYATVWASKTNLEQRKGRAGRVRPGFCFHLCSRARF 568
Cdd:TIGR01970  259 PQGRRKVVLATNIAETSLTIEGIRVVIDSGLARVARFDPKTGITRLETVRISQASATQRAGRAGRLEPGVCYRLWSEEQH 338

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384   569 DRLETHMTPEMFRTPLHEIALsiKLLRLGGIGQFLAKAIEPPPLDAVIEAEHTLRELDALDANDELTPLGRILAKLPIEP 648
Cdd:TIGR01970  339 QRLPAQDEPEILQADLSGLAL--ELAQWGAKDPSDLRWLDAPPSVALAAARQLLQRLGALDAQGRLTAHGKAMAALGCHP 416


                   ....*....
gi 672074384   649 RFGKMMIMG 657
Cdd:TIGR01970  417 RLAAMLLSA 425
DEXHc_DHX30 cd17976
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an ...
 174-349 8.02e-67

DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an important role in the assembly of the mitochondrial large ribosomal subunit. DHX30 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350734 [Multi-domain]  Cd Length: 178  Bit Score: 222.75  E-value: 8.02e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  174 LPVKKFEAEILEAISQNSVVIIRGATGCGKTTQVPQYILDDFIQNDRAAECNIVVTQPRRISAVAVAERVAYERGEEPGK 253
Cdd:cd17976     1 LPVDSHKESILSAIEQNPVVVISGDTGCGKTTRIPQFILEDYVLRGRGARCNVVITQPRRISAVSVAQRVAHELGPNLRR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  254 SCGYSVRFESILPRPHASIMFCTVGVLLRKLE--AGIRGISHVIVDEIHERDINTDFLLVVLRDVVLAYPEVRIVLMSAT 331
Cdd:cd17976    81 NVGYQVRLESRPPPRGGALLFCTVGVLLKKLQsnPRLEGVSHVIVDEVHERDVNTDFLLILLKGVLQLNPELRVVLMSAT 160

                         170
                  ....*....|....*...
gi 672074384  332 IDTTMFCEYFFNCPIIEV 349
Cdd:cd17976   161 GDNQRLSRYFGGCPVVRV 178
PRK11664 PRK11664
ATP-dependent RNA helicase HrpB; Provisional
 173-655 4.13e-63

ATP-dependent RNA helicase HrpB; Provisional


Pssm-ID: 236950 [Multi-domain]  Cd Length: 812  Bit Score: 230.97  E-value: 4.13e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  173 LLPVKKFEAEILEAISQNSVVIIRGATGCGKTTQVPQYILDDFIQNDRaaecnIVVTQPRRISAVAVAERVAYERGEEPG 252
Cdd:PRK11664    3 SLPVAAVLPELLTALKTAPQVLLKAPTGAGKSTWLPLQLLQHGGINGK-----IIMLEPRRLAARNVAQRLAEQLGEKPG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  253 KSCGYSVRFESILPrPHASIMFCTVGVLLRKLE--AGIRGISHVIVDEIHERDINTDFLLVVLRDVVLAYPE-VRIVLMS 329
Cdd:PRK11664   78 ETVGYRMRAESKVG-PNTRLEVVTEGILTRMIQrdPELSGVGLVILDEFHERSLQADLALALLLDVQQGLRDdLKLLIMS 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  330 ATIDTTMFCEYFFNCPIIEVYGRTFPVQeyfledciqmTQFIPppkdkkkkdkeddggedddancnlicgdeygpetkLS 409
Cdd:PRK11664  157 ATLDNDRLQQLLPDAPVIVSEGRSFPVE----------RRYQP-----------------------------------LP 191

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  410 MSQlneketPFEliEALLKYIETL--NVPGAVLVFLPGWNLIYTMQKHLENNshFGSHrYQILPLHSQIPREEQRKVFDP 487
Cdd:PRK11664  192 AHQ------RFD--EAVARATAELlrQESGSLLLFLPGVGEIQRVQEQLASR--VASD-VLLCPLYGALSLAEQQKAILP 260

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  488 VPDGVTKVILSTNIAETSITINDVVYVIDSCKQKVKLFTAHNNMTNYATVWASKTNLEQRKGRAGRVRPGFCFHLCSRAR 567
Cdd:PRK11664  261 APAGRRKVVLATNIAETSLTIEGIRLVVDSGLERVARFDPKTGLTRLVTQRISQASMTQRAGRAGRLEPGICLHLYSKEQ 340

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  568 FDRLETHMTPEMFRTPLHEIALSikLLRLG--GIGQFlaKAIEPPPLDAVIEAEHTLRELDALDANDELTPLGRILAKLP 645
Cdd:PRK11664  341 AERAAAQSEPEILHSDLSGLLLE--LLQWGchDPAQL--SWLDQPPAAALAAAKRLLQQLGALDGQGRLTARGRKMAALG 416

                         490
                  ....*....|
gi 672074384  646 IEPRFGKMMI 655
Cdd:PRK11664  417 NDPRLAAMLV 426
DEXHc_DHX36 cd17981
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as ...
 174-349 9.03e-63

DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as G4-resolvase 1 or G4R1, MLE-like protein 1 and RNA helicase associated with AU-rich element or RHAU) unwinds a G4-quadruplex in human telomerase RNA. DHX36 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350739 [Multi-domain]  Cd Length: 180  Bit Score: 211.24  E-value: 9.03e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  174 LPVKKFEAEILEAISQNSVVIIRGATGCGKTTQVPQYILDDFIQNDRAAECNIVVTQPRRISAVAVAERVAYERGEEP-- 251
Cdd:cd17981     1 LPSYGMKQEIINMIDNNQVTVISGETGCGKTTQVTQFILDDAIERGKGSSCRIVCTQPRRISAISVAERVAAERAESCgl 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  252 GKSCGYSVRFESILPRPHASIMFCTVGVLLRKLEAG--IRGISHVIVDEIHERDINTDFLLVVLRDVVLAYPEVRIVLMS 329
Cdd:cd17981    81 GNSTGYQIRLESRKPRKQGSILYCTTGIVLQWLQSDphLSNVSHLVLDEIHERNLQSDVLMGIVKDLLPFRSDLKVILMS 160

                         170       180
                  ....*....|....*....|
gi 672074384  330 ATIDTTMFCEYFFNCPIIEV 349
Cdd:cd17981   161 ATLNAEKFSDYFNNCPMIHI 180
PRK11131 PRK11131
ATP-dependent RNA helicase HrpA; Provisional
 153-756 1.79e-61

ATP-dependent RNA helicase HrpA; Provisional


Pssm-ID: 182986 [Multi-domain]  Cd Length: 1294  Bit Score: 230.33  E-value: 1.79e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  153 ELAYQMEQDHnlQSVLQER---------ELLPVKKFEAEILEAISQNSVVIIRGATGCGKTTQVPQYILddfiQNDRAAE 223
Cdd:PRK11131   45 EIAKEIAQAA--QRVLLREaarpeitypENLPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICL----ELGRGVK 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  224 CNIVVTQPRRISAVAVAERVAYERGEEPGKSCGYSVRF-ESILPRPHASIMfcTVGVLLRKLEAGiRGISH---VIVDEI 299
Cdd:PRK11131  119 GLIGHTQPRRLAARTVANRIAEELETELGGCVGYKVRFnDQVSDNTMVKLM--TDGILLAEIQQD-RLLMQydtIIIDEA 195

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  300 HERDINTDFLLVVLRDVVLAYPEVRIVLMSATIDTTMFCEYFFNCPIIEVYGRTFPVQeyfledciqmTQFIPppkdkkk 379
Cdd:PRK11131  196 HERSLNIDFILGYLKELLPRRPDLKVIITSATIDPERFSRHFNNAPIIEVSGRTYPVE----------VRYRP------- 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  380 kdkeddggedddancnlICGDEYGPETklsmSQLneketpfeliEALLKYIETLNV--PGAVLVFLPGWNLIYTMQKHLE 457
Cdd:PRK11131  259 -----------------IVEEADDTER----DQL----------QAIFDAVDELGRegPGDILIFMSGEREIRDTADALN 307

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  458 --NNSHfgshrYQILPLHSQIPREEQRKVFDpvPDGVTKVILSTNIAETSITINDVVYVIDSCKQKVKLFTAHNNMTNYA 535
Cdd:PRK11131  308 klNLRH-----TEILPLYARLSNSEQNRVFQ--SHSGRRIVLATNVAETSLTVPGIKYVIDPGTARISRYSYRTKVQRLP 380

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  536 TVWASKTNLEQRKGRAGRVRPGFCFHLCSRARFDRLETHMTPEMFRTPLHEIALSIKLLRLGGIGQFlaKAIEPPPLDAV 615
Cdd:PRK11131  381 IEPISQASANQRKGRCGRVSEGICIRLYSEDDFLSRPEFTDPEILRTNLASVILQMTALGLGDIAAF--PFVEAPDKRNI 458

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  616 IEAEHTLRELDALDAND-----ELTPLGRILAKLPIEPRFGKMMI----MGCIfyvgDAVCTISAATCFPEPF------- 679
Cdd:PRK11131  459 QDGVRLLEELGAITTDEqasayKLTPLGRQLAQLPVDPRLARMVLeaqkHGCV----REVMIITSALSIQDPRerpmdkq 534

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  680 -ISEGKrlgyiHRNFAgNRFSDHVALLSVfqaWDDAR-----MSGEEAEiRFCEQKRLNMATLRMTWEAKVQLKEILINS 753
Cdd:PRK11131  535 qASDEK-----HRRFA-DKESDFLAFVNL---WNYLQeqqkaLSSNQFR-RLCRTDYLNYLRVREWQDIYTQLRQVVKEL 604


                  ...
gi 672074384  754 GFP 756
Cdd:PRK11131  605 GIP 607
DEXHc_DHX57 cd17985
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the ...
 174-349 1.29e-53

DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350743 [Multi-domain]  Cd Length: 177  Bit Score: 185.04  E-value: 1.29e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  174 LPVKKFEAEILEAISQNSVVIIRGATGCGKTTQVPQYILDDFIQNDRAAECNIVVTQPRRISAVAVAERVAYERGEEPGK 253
Cdd:cd17985     1 LPAWQERETILELLEKHQVLVISGMTGCGKTTQIPQFILDNSLQGPPLPVANIICTQPRRISAISVAERVAQERAERVGQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  254 SCGYSVRFESILPRPhASIMFCTVGVLLRKLEAG--IRGISHVIVDEIHERDINTDFLLVVLRDVVLAYPEVRIVLMSAT 331
Cdd:cd17985    81 SVGYQIRLESVKSSA-TRLLYCTTGVLLRRLEGDptLQGVTHVIVDEVHERTEESDFLLLVLKDLMVQRPDLKVILMSAT 159

                         170
                  ....*....|....*...
gi 672074384  332 IDTTMFCEYFFNCPIIEV 349
Cdd:cd17985   160 LNAELFSDYFNSCPVIHI 177
DEXHc_YTHDC2 cd17987
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) ...
 174-349 4.62e-52

DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) regulates mRNA translation and stability via binding to N6-methyladenosine, a modified RNA nucleotide enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. YTHDC2 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350745 [Multi-domain]  Cd Length: 176  Bit Score: 180.41  E-value: 4.62e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  174 LPVKKFEAEILEAISQNSVVIIRGATGCGKTTQVPQYILDDFIQNdrAAECNIVVTQPRRISAVAVAERVAYERGEEPGK 253
Cdd:cd17987     1 LPVFEKQEQIVRIIKENKVVLIVGETGSGKTTQIPQFLLDDCYAN--GIPCRIFCTQPRRLAAIAVAERVAAERGEKIGQ 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  254 SCGYSVRFESILpRPHASIMFCTVGVLLRKLEAG---IRGISHVIVDEIHERDINTDFLLVVLRDVVLAYPEVRIVLMSA 330
Cdd:cd17987    79 TVGYQIRLESRV-SPKTLLTFCTNGVLLRTLMAGdsaLSTVTHVIVDEVHERDRFSDFLLTKLRDILQKHPNLKLILSSA 157

                         170
                  ....*....|....*....
gi 672074384  331 TIDTTMFCEYFFNCPIIEV 349
Cdd:cd17987   158 ALDVNLFIRYFGSCPVIYI 176
DEXHc_DHX29 cd17975
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of ...
 174-349 4.37e-49

DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of the 43S pre-initiation complex involved in translation initiation of mRNAs with structured 5'-UTRs. DHX29 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350733 [Multi-domain]  Cd Length: 183  Bit Score: 172.41  E-value: 4.37e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  174 LPVKKFEAEILEAISQNSVVIIRGATGCGKTTQVPQYILDDFIQN-DRAAECNIVVTQPRRISAVAVAERVAYERGEEPG 252
Cdd:cd17975     1 LPVFKHRESILETLKRHRVVVVAGETGSGKSTQVPQFLLEDLLLNgGTAQKCNIVCTQPRRISAMSLATRVCEELGCESG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  253 KS-----CGYSVRFESilpRPHAS--IMFCTVGVLLRKLEAG--IRGISHVIVDEIHERDINTDFLLVVLRDVVLAYPEV 323
Cdd:cd17975    81 PGgknslCGYQIRMES---RTGEAtrLLYCTTGVLLRKLQEDglLSSISHIIVDEVHERSVQSDFLLIILKEILHKRSDL 157

                         170       180
                  ....*....|....*....|....*.
gi 672074384  324 RIVLMSATIDTTMFCEYFFNCPIIEV 349
Cdd:cd17975   158 HLILMSATVDCEKFSSYFTHCPILRI 183
DEXHc_TDRD9 cd17988
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also ...
 174-341 7.95e-47

DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also known as HIG-1or NET54 or C14orf75) is a part of the nuclear PIWI-interacting RNA (piRNA) pathway essential for transposon silencing and male fertility TDRD9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350746 [Multi-domain]  Cd Length: 180  Bit Score: 165.75  E-value: 7.95e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  174 LPVKKFEAEILEAISQNSVVIIRGATGCGKTTQVPQYILDDFIQndRAAECNIVVTQPRRISAVAVAERVAYERGEEPGK 253
Cdd:cd17988     1 LPIYAKREEILSLIEANSVVIIKGATGCGKTTQLPQFILDHYYK--RGKYCNIVVTQPRRIAAISIARRVSQEREWTLGS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  254 SCGYSVRFESILPRpHASIMFCTVGVLLRKL--EAGIRGISHVIVDEIHERDINTDFLLVVLRDVVLAYP-EVRIVLMSA 330
Cdd:cd17988    79 LVGYQVGLERPASE-ETRLIYCTTGVLLQKLinNKTLTEYTHIILDEVHERDQELDFLLLVVRRLLRTNSrHVKIILMSA 157

                         170
                  ....*....|.
gi 672074384  331 TIDTTMFCEYF 341
Cdd:cd17988   158 TISCKEFADYF 168
DEXHc_DHX33 cd17978
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA ...
 174-347 4.28e-43

DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA polymerase I transcription of the 47S precursor rRNA. DHX33 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438710 [Multi-domain]  Cd Length: 178  Bit Score: 154.82  E-value: 4.28e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  174 LPVKKFEAEILEAISQNSVVIIRGATGCGKTTQVPQYILDDFIQNDRAaecnIVVTQPRRISAVAVAERVAYERGEEPGK 253
Cdd:cd17978     1 LPIYSARKRLLEELRKHDTVIIIGETGSGKTTQIPQYLYEAGFARGGM----IGITQPRRVAAVSVAKRVAEEMGVELGQ 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  254 SCGYSVRFESIlPRPHASIMFCTVGVLLRK--LEAGIRGISHVIVDEIHERDINTDF-----LLVVLRDVVLAYPEVRIV 326
Cdd:cd17978    77 LVGYSVRFDDV-TSEETRIKYMTDGMLLREaiGDPLLSKYSVIILDEAHERTVHTDVlfglvKSAQRRRKEQKLSPLKVI 155

                         170       180
                  ....*....|....*....|.
gi 672074384  327 LMSATIDTTMFCEYFFNCPII 347
Cdd:cd17978   156 IMSATLDADLFSEYFNGAPVL 176
DEXHc_DHX34 cd17979
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in ...
 174-349 1.90e-42

DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in the nonsense-mediated decay (NMD), a surveillance mechanism that degrades aberrant mRNAs. DHX34 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350737 [Multi-domain]  Cd Length: 170  Bit Score: 152.98  E-value: 1.90e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  174 LPVKKFEAEILEAISQNSVVIIRGATGCGKTTQVPQYILDdfiqndrAAECNIVVTQPRRISAVAVAERVAYERGEEPGK 253
Cdd:cd17979     1 LPIAQYREKIIELLKTHQVVIVAGDTGCGKSTQVPQYLLA-------AGFRHIACTQPRRIACISLAKRVAFESLNQYGS 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  254 SCGYSVRFESIlPRPHASIMFCTVGVLLRKLE--AGIRGISHVIVDEIHERDINTDFLLVVLRDVVLAYPEVRIVLMSAT 331
Cdd:cd17979    74 KVAYQIRFERT-RTLATKLLFLTEGLLLRQIQrdASLPQYNVLILDEVHERHLHGDFLLGVLRCLLRLRPDLKLILMSAT 152

                         170
                  ....*....|....*...
gi 672074384  332 IDTTMFCEYFFNCPIIEV 349
Cdd:cd17979   153 INIELFSGYFEGAPVVQV 170
DEXHc_DHX8 cd17971
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as ...
 169-349 2.50e-39

DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22) acts late in the splicing of pre-mRNA and mediates the release of the spliced mRNA from spliceosomes. DHX8 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350729 [Multi-domain]  Cd Length: 179  Bit Score: 144.16  E-value: 2.50e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  169 QERELLPVKKFEAEILEAISQNSVVIIRGATGCGKTTQVPQYILDDFIQNDRAAECnivvTQPRRISAVAVAERVAYERG 248
Cdd:cd17971     1 EQRESLPIYKLKEQLIQAVHDNQILVVIGETGSGKTTQITQYLAEAGYTSRGKIGC----TQPRRVAAMSVAKRVAEEFG 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  249 EEPGKSCGYSVRFESIlPRPHASIMFCTVGVLLRK--LEAGIRGISHVIVDEIHERDINTDFLLVVLRDVVLAYPEVRIV 326
Cdd:cd17971    77 CCLGQEVGYTIRFEDC-TSPETVIKYMTDGMLLREclIDPDLSQYSVIMLDEAHERTIHTDVLFGLLKKTVQKRPDLKLI 155

                         170       180
                  ....*....|....*....|...
gi 672074384  327 LMSATIDTTMFCEYFFNCPIIEV 349
Cdd:cd17971   156 VTSATLDAVKFSQYFYEAPIFTI 178
DEXHc_DHX15 cd17973
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA ...
 165-349 2.07e-37

DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. DHX15 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438709 [Multi-domain]  Cd Length: 187  Bit Score: 139.09  E-value: 2.07e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  165 QSVLQERELLPVKKFEAEILEAISQNSVVIIRGATGCGKTTQVPQYILDDFIQNDRAAEcnIVVTQPRRISAVAVAERVA 244
Cdd:cd17973     4 FEILEKRRELPVWEQKEDFLKLLKNNQILVLVGETGSGKTTQIPQFVLDDELPHQPKKL--VACTQPRRVAAMSVAQRVA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  245 YERGEEPGKSCGYSVRFESiLPRPHASIMFCTVGVLLRKLEAG--IRGISHVIVDEIHERDINTDFLLVVLRDVVLAYPE 322
Cdd:cd17973    82 EEMDVKLGEEVGYSIRFED-CSSAKTILKYMTDGMLLREAMSDplLSRYSVIILDEAHERTLATDILMGLLKEVVRRRPD 160

                         170       180
                  ....*....|....*....|....*..
gi 672074384  323 VRIVLMSATIDTTMFCEYFFNCPIIEV 349
Cdd:cd17973   161 LKLIVMSATLDAGKFQKYFDNAPLLKV 187
DEXHc_HrpA cd17989
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA ...
 174-349 2.92e-37

DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpA belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350747 [Multi-domain]  Cd Length: 173  Bit Score: 137.97  E-value: 2.92e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  174 LPVKKFEAEILEAISQNSVVIIRGATGCGKTTQVPQYILDdfiqNDRAAECNIVVTQPRRISAVAVAERVAYERGEEPGK 253
Cdd:cd17989     1 LPVSQKRDEIAKAIAENQVVIIAGETGSGKTTQLPKICLE----LGRGIRGLIGHTQPRRLAARSVAERIAEELKTELGG 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  254 SCGYSVRFESILpRPHASIMFCTVGVLLRKLEAG--IRGISHVIVDEIHERDINTDFLLVVLRDVVLAYPEVRIVLMSAT 331
Cdd:cd17989    77 AVGYKVRFTDQT-SDETCVKLMTDGILLAETQTDryLRAYDTIIIDEAHERSLNIDFLLGYLKQLLPRRPDLKVIITSAT 155

                         170
                  ....*....|....*...
gi 672074384  332 IDTTMFCEYFFNCPIIEV 349
Cdd:cd17989   156 IDAERFSRHFNNAPIIEV 173
DEXHc_DHX35 cd17980
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and ...
 174-341 3.73e-37

DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and seems to be associated with risk to thyroid cancers. It also has been shown to positively regulate poxviruses, such as Myxoma virus. DEAH-box helicase 35 (DHX35) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350738 [Multi-domain]  Cd Length: 185  Bit Score: 138.37  E-value: 3.73e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  174 LPVKKFEAEILEAISQNSVVIIRGATGCGKTTQVPQYILD-DFIQNDRAaecnIVVTQPRRISAVAVAERVAYERGEEPG 252
Cdd:cd17980     1 LPVFKLRNHILYLVENYQTIVIVGETGCGKSTQIPQYLAEaGWTAGGRV----VGCTQPRRVAAVTVAGRVAEEMGAVLG 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  253 KSCGYSVRFESILPRPHASIMFCTVGVLLRKLEAG--IRGISHVIVDEIHERDINTDFLLVVLRDVVLAYPEVRIVLMSA 330
Cdd:cd17980    77 HEVGYCIRFDDCTDPQATRIKFLTDGMLVREMMLDplLTKYSVIMLDEAHERTLYTDILIGLLKKIQKKRGDLRLIVASA 156

                         170
                  ....*....|.
gi 672074384  331 TIDTTMFCEYF 341
Cdd:cd17980   157 TLDAEKFRDFF 167
DEXHc_DHX37 cd17982
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the ...
 174-339 2.91e-36

DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the human nervous system and has been linked to schizophrenia. It also negatively regulates poxviruses such as Myxoma virus. DEAH-box helicase 37 (DHX37) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350740 [Multi-domain]  Cd Length: 191  Bit Score: 135.94  E-value: 2.91e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  174 LPVKKFEAEILEAISQNSVVIIRGATGCGKTTQVPQYILD-DFIQNDRAAECNIVVTQPRRISAVAVAERVAYERGeEPG 252
Cdd:cd17982     1 LPILAEEQEIMEAINENPVVIICGETGSGKTTQVPQFLYEaGFGSPESDNPGMIGITQPRRVAAVSMAKRVAEELN-VFG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  253 KSCGYSVRFESILpRPHASIMFCTVGVLLRKLEAG--IRGISHVIVDEIHERDINTD-----------FLLVVLRDVVLA 319
Cdd:cd17982    80 KEVSYQIRYDSTV-SENTKIKFMTDGVLLKEIQTDflLRKYSVIIIDEAHERSVNTDiligmlsrivpLRAKLYLQDQTV 158

                         170       180
                  ....*....|....*....|
gi 672074384  320 YPeVRIVLMSATIDTTMFCE 339
Cdd:cd17982   159 KP-LKLVIMSATLRVEDFTE 177
DEXHc_DHX16 cd17974
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably ...
 174-349 3.02e-35

DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably involved in pre-mRNA splicing. DHX16 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350732 [Multi-domain]  Cd Length: 174  Bit Score: 132.24  E-value: 3.02e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  174 LPVKKFEAEILEAISQNSVVIIRGATGCGKTTQVPQYILDDFIQNDRAaecNIVVTQPRRISAVAVAERVAYERGEEPGK 253
Cdd:cd17974     1 LPVYPYRDDLLAAVKEHQVLIIVGETGSGKTTQIPQYLHEAGYTKGGG---KIGCTQPRRVAAMSVAARVAEEMGVKLGN 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  254 SCGYSVRFESIlPRPHASIMFCTVGVLLRKL--EAGIRGISHVIVDEIHERDINTDFLLVVLRDVVLAYPEVRIVLMSAT 331
Cdd:cd17974    78 EVGYSIRFEDC-TSEKTVLKYMTDGMLLREFltEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPDLKLLISSAT 156

                         170
                  ....*....|....*...
gi 672074384  332 IDTTMFCEYFFNCPIIEV 349
Cdd:cd17974   157 MDAEKFSAFFDDAPIFRI 174
DEXHc_HrpB cd17990
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA ...
 174-349 4.41e-35

DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438711 [Multi-domain]  Cd Length: 174  Bit Score: 131.69  E-value: 4.41e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  174 LPVKKFEAEILEAISQNSVVIIRGATGCGKTTQVPQYILDDFIQNDRaaecNIVVTQPRRISAVAVAERVAYERGEEPGK 253
Cdd:cd17990     1 LPIAAVLPALRAALDAGGQVVLEAPPGAGKTTRVPLALLAELWIAGG----KIIVLEPRRVAARAAARRLATLLGEAPGE 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  254 SCGYSVRFESILPRpHASIMFCTVGVLLRKLEA--GIRGISHVIVDEIHERDINTDFLLVVLRDVVLAY-PEVRIVLMSA 330
Cdd:cd17990    77 TVGYRVRGESRVGR-RTRVEVVTEGVLLRRLQRdpELSGVGAVILDEFHERSLDADLALALLLEVQQLLrDDLRLLAMSA 155

                         170
                  ....*....|....*....
gi 672074384  331 TIDTTMFCEYFFNCPIIEV 349
Cdd:cd17990   156 TLDGDGLAALLPEAPVVES 174
DEXHc_DHX38 cd17983
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as ...
 174-349 6.10e-34

DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as PRP16) is involved in pre-mRNA splicing. DHX38 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350741 [Multi-domain]  Cd Length: 173  Bit Score: 128.73  E-value: 6.10e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  174 LPVKKFEAEILEAISQNSVVIIRGATGCGKTTQVPQYILDDFIQNDRAAECnivvTQPRRISAVAVAERVAYERGEEPGK 253
Cdd:cd17983     1 LPIFAVRQELLNVIRDNNVVIVVGETGSGKTTQLTQYLHEDGYTDYGMIGC----TQPRRVAAMSVAKRVSEEMGVELGE 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  254 SCGYSVRFESIlPRPHASIMFCTVGVLLRK--LEAGIRGISHVIVDEIHERDINTDFLLVVLRDVVLAYPEVRIVLMSAT 331
Cdd:cd17983    77 EVGYAIRFEDC-TSENTVIKYMTDGILLREslRDPDLDKYSAIIMDEAHERSLNTDVLFGLLREVVARRRDLKLIVTSAT 155

                         170
                  ....*....|....*...
gi 672074384  332 IDTTMFCEYFFNCPIIEV 349
Cdd:cd17983   156 MDADKFADFFGNVPIFTI 173
DEXHc_DHX40 cd17984
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the ...
 174-349 2.53e-30

DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350742 [Multi-domain]  Cd Length: 178  Bit Score: 118.42  E-value: 2.53e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  174 LPVKKFEAEILEAISQNSVVIIRGATGCGKTTQVPQYILD-DFIQNDRaaecnIVVTQPRRISAVAVAERVAYERGEEPG 252
Cdd:cd17984     1 LPIQKQRKKLVQAVRDNSFLIVTGNTGSGKTTQLPKYLYEaGFSQHGM-----IGVTQPRRVAAISVAQRVAEEMKCTLG 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  253 KSCGYSVRFESILPRPHAsIMFCTVGVLLRKLEA--GIRGISHVIVDEIHERDINTD-----FLLVVLRDVVLAYPEVRI 325
Cdd:cd17984    76 SKVGYQVRFDDCSSKETA-IKYMTDGCLLRHILAdpNLTKYSVIILDEAHERSLTTDilfglLKKLFQEKSPNRKEHLKV 154

                         170       180
                  ....*....|....*....|....
gi 672074384  326 VLMSATIDTTMFCEYFFNCPIIEV 349
Cdd:cd17984   155 VVMSATLELAKLSAFFGNCPVFDI 178
SF2-N cd00046
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ...
 190-331 8.56e-23

N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.


Pssm-ID: 350668 [Multi-domain]  Cd Length: 146  Bit Score: 95.55  E-value: 8.56e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  190 NSVVIIRGATGCGKTTQVPQYILDDFIQndraAECNIVVTQPRRISAVAVAERVAYERGeePGKSCGYSVRFESILPR-- 267
Cdd:cd00046     1 GENVLITAPTGSGKTLAALLAALLLLLK----KGKKVLVLVPTKALALQTAERLRELFG--PGIRVAVLVGGSSAEERek 74

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 672074384  268 ---PHASIMFCTVGVLLRKLEA----GIRGISHVIVDEIHERDINTDFLLVVLRDVVLA-YPEVRIVLMSAT 331
Cdd:cd00046    75 nklGDADIIIATPDMLLNLLLRedrlFLKDLKLIIVDEAHALLIDSRGALILDLAVRKAgLKNAQVILLSAT 146
DEXDc smart00487
DEAD-like helicases superfamily;
168-355 7.12e-22

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 94.87  E-value: 7.12e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384    168 LQERELLPVKKFEAEILEAISQN-SVVIIRGATGCGKTTQVPQYILDDFIQNDRaaeCNIVVTQPRRISAVAVAERVAYE 246
Cdd:smart00487    1 IEKFGFEPLRPYQKEAIEALLSGlRDVILAAPTGSGKTLAALLPALEALKRGKG---GRVLVLVPTRELAEQWAEELKKL 77

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384    247 RGEEPGKSCGYSVRFESI-----LPRPHASIMFCTVGVLLRKLEAG---IRGISHVIVDEIHERDiNTDFLLVVLRDVVL 318
Cdd:smart00487   78 GPSLGLKVVGLYGGDSKReqlrkLESGKTDILVTTPGRLLDLLENDklsLSNVDLVILDEAHRLL-DGGFGDQLEKLLKL 156

                           170       180       190
                    ....*....|....*....|....*....|....*....
gi 672074384    319 AYPEVRIVLMSATI--DTTMFCEYFFNCPIIEVYGRTFP 355
Cdd:smart00487  157 LPKNVQLLLLSATPpeEIENLLELFLNDPVFIDVGFTPL 195
HA2 smart00847
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ...
 624-705 5.33e-21

Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 214852 [Multi-domain]  Cd Length: 82  Bit Score: 88.09  E-value: 5.33e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384    624 ELDALDANDELTPLGRILAKLPIEPRFGKMMIMGCIFYVGDAVCTISAATCFPEPFISE-GKRLGYIHRNFAGNRfSDHV 702
Cdd:smart00847    1 ELGALDDDGRLTPLGRKMAELPLDPRLAKMLLAAAEFGCLDEILTIVAMLSVGDPRPKEkREDADAARRRFADPE-SDHL 79


                    ...
gi 672074384    703 ALL 705
Cdd:smart00847   80 TLL 82
HA2 pfam04408
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ...
 618-704 1.16e-19

Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 461295 [Multi-domain]  Cd Length: 104  Bit Score: 84.98  E-value: 1.16e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384   618 AEHTLRELDALDANDELTPLGRILAKLPIEPRFGKMMIMGCIFYVGDAVCTISAATCFPEPFISEG-------------- 683
Cdd:pfam04408    1 ALELLYYLGALDEDGELTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSVRDPFVQPNfldprsaakaarrr 80

                           90       100
                   ....*....|....*....|....
gi 672074384   684 --KRLGYIHRNFAGNRF-SDHVAL 704
Cdd:pfam04408   81 rrAADEKARAKFARLDLeGDHLTL 104
OB_NTP_bind pfam07717
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ...
 780-859 3.55e-19

Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.


Pssm-ID: 400182 [Multi-domain]  Cd Length: 82  Bit Score: 83.07  E-value: 3.55e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384   780 LLAFGVYPNVCYHKEKRKILTT--EGRNALIHKSSVNCpfssQDMKYPSPFFVFGEKIRTRAISAKGMTLVTPLQLLLFA 857
Cdd:pfam07717    4 ALAAGLYPNVARRDPKGKGYTTlsDNQRVFIHPSSVLF----NEKTFPPEWVVYQELVETTKVYIRTVTAISPEWLLLFA 79


                   ..
gi 672074384   858 SK 859
Cdd:pfam07717   80 PH 81
DEXHc_DHX32 cd17977
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the ...
 174-349 9.36e-19

DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350735 [Multi-domain]  Cd Length: 176  Bit Score: 84.88  E-value: 9.36e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  174 LPVKKFEAEILEAISQNSVVIIRGATGCGKTTQVPQ----YILDDFIQNDraaecNIVVTQPRRISAVAVAERVAYERGE 249
Cdd:cd17977     1 LPVWEAKYEFMESLAHNQIVIVSGDAKTGKSSQIPQwcaeYCLSAHYQHG-----VVVCTQVHKQTAVWLALRVADEMDV 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  250 EPGKSCGYSVRFESILPRpHASIMFCTVGVLLRKLEA----GIRGIshVIVDEIHERDINTDFLLVVLRDVVLAYPEVRI 325
Cdd:cd17977    76 NIGHEVGYVIPFENCCTN-ETILRYCTDDMLLREMMSdpllESYGV--IILDDAHERTVSTDVLLGLLKDVLLSRPELKL 152

                         170       180
                  ....*....|....*....|....
gi 672074384  326 VLMSATIDTTMFCEYFFNCPIIEV 349
Cdd:cd17977   153 VIITCPHLSSKLLSYYGNVPLIEV 176
DSRM_DHX9_rpt2 cd19855
second double-stranded RNA binding motif of DEAH box protein 9 (DHX9) and similar proteins; ...
 1-38 3.78e-18

second double-stranded RNA binding motif of DEAH box protein 9 (DHX9) and similar proteins; DHX9 (EC 3.6.4.13; also known as ATP-dependent RNA helicase A, DExH-box helicase 9 (DDX9), Leukophysin (LKP), nuclear DNA helicase II (NDH II), NDH2, or RNA helicase A) is a multifunctional ATP-dependent nucleic acid helicase that unwinds DNA and RNA in a 3' to 5' direction and plays important roles in many processes, such as DNA replication, transcriptional activation, post-transcriptional RNA regulation, mRNA translation and RNA-mediated gene silencing. It contains two double-stranded RNA binding motifs (DSRMs) at the N-terminal region. This model corresponds to the second motif. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure.


Pssm-ID: 380684  Cd Length: 75  Bit Score: 79.95  E-value: 3.78e-18
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 672074384    1 MTIYIKQLGRRIFAREHGSNKKLAAQSCALSLVRQLYH 38
Cdd:cd19855    38 LSIFVKQLGKTIYARETGSNKKLASQSCALSLVRQLYH 75
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
 421-554 1.07e-16

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 76.87  E-value: 1.07e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384   421 ELIEALLKYIETLNvPGAVLVFLPgwnliytMQKHLENNSHFGSHRYQILPLHSQIPREEQRKVFDPVPDGVTKVILSTN 500
Cdd:pfam00271    1 EKLEALLELLKKER-GGKVLIFSQ-------TKKTLEAELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATD 72

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 672074384   501 IAETSITINDVVYVIDsckqkvklFTAHNNMTNYatvwasktnlEQRKGRAGRV 554
Cdd:pfam00271   73 VAERGLDLPDVDLVIN--------YDLPWNPASY----------IQRIGRAGRA 108
DEXQc_DQX1 cd17986
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 ...
 174-349 4.39e-15

DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 (DQX1) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350744 [Multi-domain]  Cd Length: 177  Bit Score: 74.55  E-value: 4.39e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  174 LPVKKFEAEILEAI-SQNSVVIIRGATGCGKTTQVPQYILDdFIQNDRAAECNIVVTQPRRISAVAVAERVAYERGEEPG 252
Cdd:cd17986     1 LPIWAAKFTFLEQLeSPSGIVLVSGEPGSGKSTQVPQWCAE-FALSRGFQKGQVTVTQPHPLAARSLALRVADEMDLNLG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  253 KSCGYSVRFESILPrPHASIMFCTVGVLLRKLEA--GIRGISHVIVDEIHERDINTDFLLVVLRDVVLAYPEVRIVLMSA 330
Cdd:cd17986    80 HEVGYSIPQEDCTG-PNTILRFCWDRLLLQEMTStpLLGAWGVVVLDEAQERSVASDSLLGLLKDVRLQRPELRVVVVTS 158

                         170
                  ....*....|....*....
gi 672074384  331 TIDTTMFCEYFFNCPIIEV 349
Cdd:cd17986   159 PALEPKLRAFWGNPPVVHV 177
HELICc smart00490
helicase superfamily c-terminal domain;
461-553 1.60e-14

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 69.93  E-value: 1.60e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384    461 HFGSHRYQILPLHSQIPREEQRKVFDPVPDGVTKVILSTNIAETSITINDVVYVIDSCkqkvklftahnnmtnyatVWAS 540
Cdd:smart00490    6 LLKELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYD------------------LPWS 67

                            90
                    ....*....|...
gi 672074384    541 KTNLEQRKGRAGR 553
Cdd:smart00490   68 PASYIQRIGRAGR 80
PHA02653 PHA02653
RNA helicase NPH-II; Provisional
 180-557 2.19e-14

RNA helicase NPH-II; Provisional


Pssm-ID: 177443 [Multi-domain]  Cd Length: 675  Bit Score: 77.71  E-value: 2.19e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  180 EAEILEAISQNSVVIIRGATGCGKTTQVPQ------YILDDFIQNDR----AAECNIVVTQPRrisavavaerVAYER-- 247
Cdd:PHA02653  169 QLKIFEAWISRKPVVLTGGTGVGKTSQVPKlllwfnYLFGGFDNLDKidpnFIERPIVLSLPR----------VALVRlh 238

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  248 GEEPGKSCGY--------SVRFESIL-------PRPHAsIMFCTVGVLLRKLeagiRGISHVIVDEIHERDINTDFLLVV 312
Cdd:PHA02653  239 SITLLKSLGFdeidgspiSLKYGSIPdelintnPKPYG-LVFSTHKLTLNKL----FDYGTVIIDEVHEHDQIGDIIIAV 313

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  313 LRDVVLaypEVR-IVLMSATI--DTTMFCEYFFNCPIIEVYGRT-FPVQEYFLEDCIQmtqfipPPKDKkkkdkeddgge 388
Cdd:PHA02653  314 ARKHID---KIRsLFLMTATLedDRDRIKEFFPNPAFVHIPGGTlFPISEVYVKNKYN------PKNKR----------- 373

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  389 dddancnlicgdEYGPETKLSMSQlneketpfelieALLKYieTLNVPGAVLVFLPGWNLIYTMQKHLEnNSHFGshrYQ 468
Cdd:PHA02653  374 ------------AYIEEEKKNIVT------------ALKKY--TPPKGSSGIVFVASVSQCEEYKKYLE-KRLPI---YD 423

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  469 ILPLHSQIPREEQ--RKVFDpvPDGVTkVILSTNIAETSITINDVVYVIDSCKQKVKLFTAHNNMtnyatvWASKTNLEQ 546
Cdd:PHA02653  424 FYIIHGKVPNIDEilEKVYS--SKNPS-IIISTPYLESSVTIRNATHVYDTGRVYVPEPFGGKEM------FISKSMRTQ 494

                         410
                  ....*....|.
gi 672074384  547 RKGRAGRVRPG 557
Cdd:PHA02653  495 RKGRVGRVSPG 505
DEAD pfam00270
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ...
 181-335 2.14e-06

DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.


Pssm-ID: 425570 [Multi-domain]  Cd Length: 165  Bit Score: 49.16  E-value: 2.14e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384   181 AEILEAISQNSVVIIRGATGCGKTT--QVPqyILDDFIQNDRAAECnIVVTqPRRISAVAVAERVayergEEPGKSCGYS 258
Cdd:pfam00270    5 AEAIPAILEGRDVLVQAPTGSGKTLafLLP--ALEALDKLDNGPQA-LVLA-PTRELAEQIYEEL-----KKLGKGLGLK 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384   259 VRFE----------SILPRPHasIMFCTVGVLLR--KLEAGIRGISHVIVDEIHeRDINTDFLLVVLRDVVLAYPEVRIV 326
Cdd:pfam00270   76 VASLlggdsrkeqlEKLKGPD--ILVGTPGRLLDllQERKLLKNLKLLVLDEAH-RLLDMGFGPDLEEILRRLPKKRQIL 152


                   ....*....
gi 672074384   327 LMSATIDTT 335
Cdd:pfam00270  153 LLSATLPRN 161
DEXHc_Ski2 cd17921
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ...
 178-333 1.41e-03

DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350679 [Multi-domain]  Cd Length: 181  Bit Score: 41.09  E-value: 1.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  178 KFEAEILEAI--SQNSVVIirGA-TGCGKTTQVPQYILDDFIQNDRaaecNIVVTQPRRisavAVAERVAY---ERGEEP 251
Cdd:cd17921     4 PIQREALRALylSGDSVLV--SApTSSGKTLIAELAILRALATSGG----KAVYIAPTR----ALVNQKEAdlrERFGPL 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074384  252 GKSCG--YSVRFESILPRPHASIMFCT---VGVLLRKL-EAGIRGISHVIVDEIH-----------ERDINTdfllvvlr 314
Cdd:cd17921    74 GKNVGllTGDPSVNKLLLAEADILVATpekLDLLLRNGgERLIQDVRLVVVDEAHligdgergvvlELLLSR-------- 145

                         170
                  ....*....|....*....
gi 672074384  315 dVVLAYPEVRIVLMSATID 333
Cdd:cd17921   146 -LLRINKNARFVGLSATLP 163
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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