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Conserved domains on  [gi|672086269|ref|XP_008771119|]
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cell division cycle and apoptosis regulator protein 1 isoform X7 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DBC1 pfam14443
DBC1; DBC1 and it homologs from diverse eukaryotes are a catalytically inactive version of the ...
 284-409 3.52e-64

DBC1; DBC1 and it homologs from diverse eukaryotes are a catalytically inactive version of the Nudix hydrolase (MutT) domain. DBC1 is predicted to bind NAD metabolites and regulate the activity of SIRT1 or related deacetylases by sensing the soluble products or substrates of the NAD-dependent deacetylation reaction.


:

Pssm-ID: 464175  Cd Length: 123  Bit Score: 211.82  E-value: 3.52e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672086269  284 QHPARLVKFLVGMKGKD-EAMAIGGHWSPSLDGPNPEKDPSVLIKTAIRCCKALTGIDLSVCTQWYRFAEIRYHRpeetH 362
Cdd:pfam14443   1 VHPCKLLKFLVGDRGKDnEIMAIGGPWSPSLDGADPTTDPSVLIRTAIRTTKALTGIDLSNCTQWYRFAEVHYYR----P 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 672086269  363 KGRTVPAHVETVVLFFPDVWHCLPTRSEWETLSRGYKQQLVEKLQGE 409
Cdd:pfam14443  77 KTDGFPSRQEITVIFLPDVSSCLPSLEEWESLWLQYRKALLEKEREA 123
LAIKA pfam19256
LAIKA domain; This presumed domain is found exclusively in the CCAR1 protein.
 528-595 3.67e-33

LAIKA domain; This presumed domain is found exclusively in the CCAR1 protein.


:

Pssm-ID: 466012 [Multi-domain]  Cd Length: 68  Bit Score: 121.97  E-value: 3.67e-33
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 672086269  528 LPDEPAIIVHPNWAAKSGKFDCSIMSLSVLLDYRLEDNKEHSFEVSLFAELFNEMLQRDFGVRIYKSL 595
Cdd:pfam19256   1 LPAEPAILVRPNRLAKGGKFDCKSLSLDGLLDYREDDTKESTFEVSLFAELFHEMLQRDFGFTIYKAL 68
BURAN pfam19257
BURAN domain; This presumed domain is found exclusively in the CCAR1 protein.
 177-259 3.98e-29

BURAN domain; This presumed domain is found exclusively in the CCAR1 protein.


:

Pssm-ID: 466013  Cd Length: 82  Bit Score: 111.25  E-value: 3.98e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672086269  177 DCPSCDMMELRRRYQNLYIPSDFFDAQFTWVDAFPLSRPFQLGNYCNFYVMHREVESLEKNVAVLDPPDADhLYSAKVML 256
Cdd:pfam19257   1 DSVERDYLELRKRYPRLYIPSDFSKLVLCWVETFPPLSPLPLDTPVSFHVMEKEVEPPLEQPAEAALEPAD-RYNAKVML 79


                  ...
gi 672086269  257 MAS 259
Cdd:pfam19257  80 LSG 82
SAP pfam02037
SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding ...
 442-475 9.08e-07

SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding domain found in diverse nuclear and cytoplasmic proteins.


:

Pssm-ID: 460424 [Multi-domain]  Cd Length: 35  Bit Score: 45.85  E-value: 9.08e-07
                          10        20        30
                  ....*....|....*....|....*....|....
gi 672086269  442 KAMKVNDLRKELESRALSSKGLKSQLIARLTKQL 475
Cdd:pfam02037   2 SKLTVAELKEELRKRGLPTSGKKAELIERLQEYL 35
PRK10927 super family cl35972
cell division protein FtsN;
5-111 1.45e-04

cell division protein FtsN;


The actual alignment was detected with superfamily member PRK10927:

Pssm-ID: 236797 [Multi-domain]  Cd Length: 319  Bit Score: 45.06  E-value: 1.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672086269   5 WN----AQRIQTLPNQNQ----SQTQPLLKTPTAVIQPIVPQTTFGVQAQPQPQSLLQAQISAASitpllqtqpqpllqq 76
Cdd:PRK10927 141 WNeqtpEQRQQTLQRQRQaqqlAEQQRLAQQSRTTEQSWQQQTRTSQAAPVQAQPRQSKPASTQQ--------------- 205

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 672086269  77 pqQKAGLLQPPVRIVSQPQP------ARRLDPPSRFSGRND 111
Cdd:PRK10927 206 --PYQDLLQTPAHTTAQSKPqqaapvTRAADAPKPTAEKKD 244
HMMR_N super family cl25727
Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of ...
 856-961 3.76e-03

Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of eukaryotic hyaluronan-mediated motility receptor proteins. The protein is functionally associated with BRCA1 and thus predicted to be a common, low-penetrance breast cancer candidate.


The actual alignment was detected with superfamily member pfam15905:

Pssm-ID: 464932 [Multi-domain]  Cd Length: 329  Bit Score: 40.56  E-value: 3.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672086269  856 LEKSEKVRAEVEQKLQLLEEKTDEDGKTILNLENSNKSLSGELREV---KKDLGQLQENLKVSENMNLQFENQLNKTLRN 932
Cdd:pfam15905 193 LEHSKGKVAQLEEKLVSTEKEKIEEKSETEKLLEYITELSCVSEQVekyKLDIAQLEELLKEKNDEIESLKQSLEEKEQE 272

                          90       100       110
                  ....*....|....*....|....*....|....
gi 672086269  933 LSTVMDDIHTVLK-----KDNVKNEDRDQKSKEN 961
Cdd:pfam15905 273 LSKQIKDLNEKCKlleseKEELLREYEEKEQTLN 306
 
Name Accession Description Interval E-value
DBC1 pfam14443
DBC1; DBC1 and it homologs from diverse eukaryotes are a catalytically inactive version of the ...
 284-409 3.52e-64

DBC1; DBC1 and it homologs from diverse eukaryotes are a catalytically inactive version of the Nudix hydrolase (MutT) domain. DBC1 is predicted to bind NAD metabolites and regulate the activity of SIRT1 or related deacetylases by sensing the soluble products or substrates of the NAD-dependent deacetylation reaction.


Pssm-ID: 464175  Cd Length: 123  Bit Score: 211.82  E-value: 3.52e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672086269  284 QHPARLVKFLVGMKGKD-EAMAIGGHWSPSLDGPNPEKDPSVLIKTAIRCCKALTGIDLSVCTQWYRFAEIRYHRpeetH 362
Cdd:pfam14443   1 VHPCKLLKFLVGDRGKDnEIMAIGGPWSPSLDGADPTTDPSVLIRTAIRTTKALTGIDLSNCTQWYRFAEVHYYR----P 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 672086269  363 KGRTVPAHVETVVLFFPDVWHCLPTRSEWETLSRGYKQQLVEKLQGE 409
Cdd:pfam14443  77 KTDGFPSRQEITVIFLPDVSSCLPSLEEWESLWLQYRKALLEKEREA 123
LAIKA pfam19256
LAIKA domain; This presumed domain is found exclusively in the CCAR1 protein.
 528-595 3.67e-33

LAIKA domain; This presumed domain is found exclusively in the CCAR1 protein.


Pssm-ID: 466012 [Multi-domain]  Cd Length: 68  Bit Score: 121.97  E-value: 3.67e-33
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 672086269  528 LPDEPAIIVHPNWAAKSGKFDCSIMSLSVLLDYRLEDNKEHSFEVSLFAELFNEMLQRDFGVRIYKSL 595
Cdd:pfam19256   1 LPAEPAILVRPNRLAKGGKFDCKSLSLDGLLDYREDDTKESTFEVSLFAELFHEMLQRDFGFTIYKAL 68
BURAN pfam19257
BURAN domain; This presumed domain is found exclusively in the CCAR1 protein.
 177-259 3.98e-29

BURAN domain; This presumed domain is found exclusively in the CCAR1 protein.


Pssm-ID: 466013  Cd Length: 82  Bit Score: 111.25  E-value: 3.98e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672086269  177 DCPSCDMMELRRRYQNLYIPSDFFDAQFTWVDAFPLSRPFQLGNYCNFYVMHREVESLEKNVAVLDPPDADhLYSAKVML 256
Cdd:pfam19257   1 DSVERDYLELRKRYPRLYIPSDFSKLVLCWVETFPPLSPLPLDTPVSFHVMEKEVEPPLEQPAEAALEPAD-RYNAKVML 79


                  ...
gi 672086269  257 MAS 259
Cdd:pfam19257  80 LSG 82
SAP pfam02037
SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding ...
 442-475 9.08e-07

SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding domain found in diverse nuclear and cytoplasmic proteins.


Pssm-ID: 460424 [Multi-domain]  Cd Length: 35  Bit Score: 45.85  E-value: 9.08e-07
                          10        20        30
                  ....*....|....*....|....*....|....
gi 672086269  442 KAMKVNDLRKELESRALSSKGLKSQLIARLTKQL 475
Cdd:pfam02037   2 SKLTVAELKEELRKRGLPTSGKKAELIERLQEYL 35
SAP smart00513
Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation;
442-475 1.03e-06

Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation;


Pssm-ID: 128789 [Multi-domain]  Cd Length: 35  Bit Score: 45.94  E-value: 1.03e-06
                           10        20        30
                   ....*....|....*....|....*....|....
gi 672086269   442 KAMKVNDLRKELESRALSSKGLKSQLIARLTKQL 475
Cdd:smart00513   2 AKLKVSELKDELKKRGLSTSGTKAELVDRLLEAL 35
PRK10927 PRK10927
cell division protein FtsN;
5-111 1.45e-04

cell division protein FtsN;


Pssm-ID: 236797 [Multi-domain]  Cd Length: 319  Bit Score: 45.06  E-value: 1.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672086269   5 WN----AQRIQTLPNQNQ----SQTQPLLKTPTAVIQPIVPQTTFGVQAQPQPQSLLQAQISAASitpllqtqpqpllqq 76
Cdd:PRK10927 141 WNeqtpEQRQQTLQRQRQaqqlAEQQRLAQQSRTTEQSWQQQTRTSQAAPVQAQPRQSKPASTQQ--------------- 205

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 672086269  77 pqQKAGLLQPPVRIVSQPQP------ARRLDPPSRFSGRND 111
Cdd:PRK10927 206 --PYQDLLQTPAHTTAQSKPqqaapvTRAADAPKPTAEKKD 244
HMMR_N pfam15905
Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of ...
 856-961 3.76e-03

Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of eukaryotic hyaluronan-mediated motility receptor proteins. The protein is functionally associated with BRCA1 and thus predicted to be a common, low-penetrance breast cancer candidate.


Pssm-ID: 464932 [Multi-domain]  Cd Length: 329  Bit Score: 40.56  E-value: 3.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672086269  856 LEKSEKVRAEVEQKLQLLEEKTDEDGKTILNLENSNKSLSGELREV---KKDLGQLQENLKVSENMNLQFENQLNKTLRN 932
Cdd:pfam15905 193 LEHSKGKVAQLEEKLVSTEKEKIEEKSETEKLLEYITELSCVSEQVekyKLDIAQLEELLKEKNDEIESLKQSLEEKEQE 272

                          90       100       110
                  ....*....|....*....|....*....|....
gi 672086269  933 LSTVMDDIHTVLK-----KDNVKNEDRDQKSKEN 961
Cdd:pfam15905 273 LSKQIKDLNEKCKlleseKEELLREYEEKEQTLN 306
 
Name Accession Description Interval E-value
DBC1 pfam14443
DBC1; DBC1 and it homologs from diverse eukaryotes are a catalytically inactive version of the ...
 284-409 3.52e-64

DBC1; DBC1 and it homologs from diverse eukaryotes are a catalytically inactive version of the Nudix hydrolase (MutT) domain. DBC1 is predicted to bind NAD metabolites and regulate the activity of SIRT1 or related deacetylases by sensing the soluble products or substrates of the NAD-dependent deacetylation reaction.


Pssm-ID: 464175  Cd Length: 123  Bit Score: 211.82  E-value: 3.52e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672086269  284 QHPARLVKFLVGMKGKD-EAMAIGGHWSPSLDGPNPEKDPSVLIKTAIRCCKALTGIDLSVCTQWYRFAEIRYHRpeetH 362
Cdd:pfam14443   1 VHPCKLLKFLVGDRGKDnEIMAIGGPWSPSLDGADPTTDPSVLIRTAIRTTKALTGIDLSNCTQWYRFAEVHYYR----P 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 672086269  363 KGRTVPAHVETVVLFFPDVWHCLPTRSEWETLSRGYKQQLVEKLQGE 409
Cdd:pfam14443  77 KTDGFPSRQEITVIFLPDVSSCLPSLEEWESLWLQYRKALLEKEREA 123
LAIKA pfam19256
LAIKA domain; This presumed domain is found exclusively in the CCAR1 protein.
 528-595 3.67e-33

LAIKA domain; This presumed domain is found exclusively in the CCAR1 protein.


Pssm-ID: 466012 [Multi-domain]  Cd Length: 68  Bit Score: 121.97  E-value: 3.67e-33
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 672086269  528 LPDEPAIIVHPNWAAKSGKFDCSIMSLSVLLDYRLEDNKEHSFEVSLFAELFNEMLQRDFGVRIYKSL 595
Cdd:pfam19256   1 LPAEPAILVRPNRLAKGGKFDCKSLSLDGLLDYREDDTKESTFEVSLFAELFHEMLQRDFGFTIYKAL 68
BURAN pfam19257
BURAN domain; This presumed domain is found exclusively in the CCAR1 protein.
 177-259 3.98e-29

BURAN domain; This presumed domain is found exclusively in the CCAR1 protein.


Pssm-ID: 466013  Cd Length: 82  Bit Score: 111.25  E-value: 3.98e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672086269  177 DCPSCDMMELRRRYQNLYIPSDFFDAQFTWVDAFPLSRPFQLGNYCNFYVMHREVESLEKNVAVLDPPDADhLYSAKVML 256
Cdd:pfam19257   1 DSVERDYLELRKRYPRLYIPSDFSKLVLCWVETFPPLSPLPLDTPVSFHVMEKEVEPPLEQPAEAALEPAD-RYNAKVML 79


                  ...
gi 672086269  257 MAS 259
Cdd:pfam19257  80 LSG 82
SAP pfam02037
SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding ...
 442-475 9.08e-07

SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding domain found in diverse nuclear and cytoplasmic proteins.


Pssm-ID: 460424 [Multi-domain]  Cd Length: 35  Bit Score: 45.85  E-value: 9.08e-07
                          10        20        30
                  ....*....|....*....|....*....|....
gi 672086269  442 KAMKVNDLRKELESRALSSKGLKSQLIARLTKQL 475
Cdd:pfam02037   2 SKLTVAELKEELRKRGLPTSGKKAELIERLQEYL 35
SAP smart00513
Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation;
442-475 1.03e-06

Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation;


Pssm-ID: 128789 [Multi-domain]  Cd Length: 35  Bit Score: 45.94  E-value: 1.03e-06
                           10        20        30
                   ....*....|....*....|....*....|....
gi 672086269   442 KAMKVNDLRKELESRALSSKGLKSQLIARLTKQL 475
Cdd:smart00513   2 AKLKVSELKDELKKRGLSTSGTKAELVDRLLEAL 35
PRK10927 PRK10927
cell division protein FtsN;
5-111 1.45e-04

cell division protein FtsN;


Pssm-ID: 236797 [Multi-domain]  Cd Length: 319  Bit Score: 45.06  E-value: 1.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672086269   5 WN----AQRIQTLPNQNQ----SQTQPLLKTPTAVIQPIVPQTTFGVQAQPQPQSLLQAQISAASitpllqtqpqpllqq 76
Cdd:PRK10927 141 WNeqtpEQRQQTLQRQRQaqqlAEQQRLAQQSRTTEQSWQQQTRTSQAAPVQAQPRQSKPASTQQ--------------- 205

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 672086269  77 pqQKAGLLQPPVRIVSQPQP------ARRLDPPSRFSGRND 111
Cdd:PRK10927 206 --PYQDLLQTPAHTTAQSKPqqaapvTRAADAPKPTAEKKD 244
PHA03356 PHA03356
tegument protein UL11; Provisional
 86-118 1.48e-03

tegument protein UL11; Provisional


Pssm-ID: 177594  Cd Length: 93  Bit Score: 38.71  E-value: 1.48e-03
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 672086269  86 PPVRIVSQP---QPARRLDPPSRFSGRNDRGDQVPN 118
Cdd:PHA03356  50 PELRVVTQPpgrQPPRPSGPPSRHTRHWSPSGARPA 85
HMMR_N pfam15905
Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of ...
 856-961 3.76e-03

Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of eukaryotic hyaluronan-mediated motility receptor proteins. The protein is functionally associated with BRCA1 and thus predicted to be a common, low-penetrance breast cancer candidate.


Pssm-ID: 464932 [Multi-domain]  Cd Length: 329  Bit Score: 40.56  E-value: 3.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672086269  856 LEKSEKVRAEVEQKLQLLEEKTDEDGKTILNLENSNKSLSGELREV---KKDLGQLQENLKVSENMNLQFENQLNKTLRN 932
Cdd:pfam15905 193 LEHSKGKVAQLEEKLVSTEKEKIEEKSETEKLLEYITELSCVSEQVekyKLDIAQLEELLKEKNDEIESLKQSLEEKEQE 272

                          90       100       110
                  ....*....|....*....|....*....|....
gi 672086269  933 LSTVMDDIHTVLK-----KDNVKNEDRDQKSKEN 961
Cdd:pfam15905 273 LSKQIKDLNEKCKlleseKEELLREYEEKEQTLN 306
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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