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Conserved domains on  [gi|688553852|ref|XP_009299555|]
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ribose-phosphate pyrophosphokinase 1 isoform X2 [Danio rerio]

Protein Classification

ribose-phosphate pyrophosphokinase( domain architecture ID 11421473)

ribose-phosphate pyrophosphokinase catalyzes the transfer of the pyrophosphoryl group from ATP to the 1-hydroxyl of ribose-5-phosphate to form the the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP)

CATH:  3.40.50.2020
EC:  2.7.6.1
Gene Ontology:  GO:0005524|GO:0002189|GO:0016301|GO:0016310|GO:0004749
PubMed:  11751055

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PrsA COG0462
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; ...
 1-317 2.95e-173

Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; Phosphoribosylpyrophosphate synthetase is part of the Pathway/BioSystem: Histidine biosynthesis, Purine biosynthesis


:

Pssm-ID: 440230 [Multi-domain]  Cd Length: 311  Bit Score: 482.25  E-value: 2.95e-173
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553852   1 MPNIKIFSGSSHPDLSQKIADRLGLELGKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEINDNLMELLIMINACKIA 80
Cdd:COG0462    1 MKDLKIFSGNANPELAEEIAEYLGVPLGKAEVRRFSDGEIYVRIEESVRGRDVFVIQSTSPPVNDNLMELLIMIDALKRA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553852  81 SASRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIKEniN 160
Cdd:COG0462   81 SARRITAVIPYYGYARQDRKFRPREPITAKLVADLLEAAGADRVLTVDLHAPQIQGFFDIPVDHLYAAPLLADYIKS--K 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553852 161 EWKNCTIVSPDAGGAKRcggVTSIADRLNVDFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTVCHAADKLV 240
Cdd:COG0462  159 DLEDLVVVSPDVGGVKR---ARAFAKRLGAPLAIIDKRRPGANEVEVMNIIGDVEGKTCIIVDDMIDTGGTLVEAAEALK 235

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 688553852 241 SAGAIKVYAILTHGIFSGPAISRINNANFEAVVVTNTIPQEDKiKHCSKIQVIDISMILAEAIRRTHNGESVSYLFS 317
Cdd:COG0462  236 EAGAKSVYAAATHGVLSGPAVERLENSPIDELVVTDTIPLPEE-KRCDKIKVLSVAPLLAEAIRRIHEGESVSSLFD 311
 
Name Accession Description Interval E-value
PrsA COG0462
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; ...
 1-317 2.95e-173

Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; Phosphoribosylpyrophosphate synthetase is part of the Pathway/BioSystem: Histidine biosynthesis, Purine biosynthesis


Pssm-ID: 440230 [Multi-domain]  Cd Length: 311  Bit Score: 482.25  E-value: 2.95e-173
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553852   1 MPNIKIFSGSSHPDLSQKIADRLGLELGKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEINDNLMELLIMINACKIA 80
Cdd:COG0462    1 MKDLKIFSGNANPELAEEIAEYLGVPLGKAEVRRFSDGEIYVRIEESVRGRDVFVIQSTSPPVNDNLMELLIMIDALKRA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553852  81 SASRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIKEniN 160
Cdd:COG0462   81 SARRITAVIPYYGYARQDRKFRPREPITAKLVADLLEAAGADRVLTVDLHAPQIQGFFDIPVDHLYAAPLLADYIKS--K 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553852 161 EWKNCTIVSPDAGGAKRcggVTSIADRLNVDFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTVCHAADKLV 240
Cdd:COG0462  159 DLEDLVVVSPDVGGVKR---ARAFAKRLGAPLAIIDKRRPGANEVEVMNIIGDVEGKTCIIVDDMIDTGGTLVEAAEALK 235

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 688553852 241 SAGAIKVYAILTHGIFSGPAISRINNANFEAVVVTNTIPQEDKiKHCSKIQVIDISMILAEAIRRTHNGESVSYLFS 317
Cdd:COG0462  236 EAGAKSVYAAATHGVLSGPAVERLENSPIDELVVTDTIPLPEE-KRCDKIKVLSVAPLLAEAIRRIHEGESVSSLFD 311
PRK01259 PRK01259
ribose-phosphate diphosphokinase;
4-316 1.31e-162

ribose-phosphate diphosphokinase;


Pssm-ID: 234929 [Multi-domain]  Cd Length: 309  Bit Score: 455.35  E-value: 1.31e-162
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553852   4 IKIFSGSSHPDLSQKIADRLGLELGKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEINDNLMELLIMINACKIASAS 83
Cdd:PRK01259   1 MKLFAGNANPELAEKIAKYLGIPLGKASVGRFSDGEISVEINENVRGKDVFIIQSTCAPTNDNLMELLIMIDALKRASAG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553852  84 RVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIKEniNEWK 163
Cdd:PRK01259  81 RITAVIPYFGYARQDRKARSRVPITAKLVANLLETAGADRVLTMDLHADQIQGFFDIPVDNLYGSPILLEDIKQ--KNLE 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553852 164 NCTIVSPDAGGAKRcggVTSIADRLNVDFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTVCHAADKLVSAG 243
Cdd:PRK01259 159 NLVVVSPDVGGVVR---ARALAKRLDADLAIIDKRRPRANVSEVMNIIGDVEGRDCILVDDMIDTAGTLCKAAEALKERG 235

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 688553852 244 AIKVYAILTHGIFSGPAISRINNANFEAVVVTNTIPQEDKIKHCSKIQVIDISMILAEAIRRTHNGESVSYLF 316
Cdd:PRK01259 236 AKSVYAYATHPVLSGGAIERIENSVIDELVVTDSIPLSEEAKKCDKIRVLSVAPLLAEAIRRISNEESVSSLF 308
ribP_PPkin TIGR01251
ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In ...
 4-317 1.84e-154

ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In some systems, close homologs lacking enzymatic activity exist and perform regulatory functions. The model is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 273523 [Multi-domain]  Cd Length: 308  Bit Score: 434.78  E-value: 1.84e-154
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553852    4 IKIFSGSSHPDLSQKIADRLGLELGKVVTKKFSNQETCVEIGESVRGEDVYIV-QSGCGEINDNLMELLIMINACKIASA 82
Cdd:TIGR01251   1 MKIFSGSSNQELAQKVAKNLGLPLGDVEVKRFPDGELYVRINESVRGKDVFIIqQSTSAPVNDNLMELLIMIDALKRASA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553852   83 SRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIKENIneW 162
Cdd:TIGR01251  81 KSITAVIPYYGYARQDKKFKSREPISAKLVANLLETAGADRVLTVDLHSPQIQGFFDVPVDNLYASPVLAEYLKKKI--L 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553852  163 KNCTIVSPDAGGAKRcggVTSIADRLNVDFALIHKERK-KANEVDRMVLVGDVKDRVAILVDDMADTCGTVCHAADKLVS 241
Cdd:TIGR01251 159 DNPVVVSPDAGGVER---AKKVADALGCPLAIIDKRRIsATNEVEVMNLVGDVEGKDVVIVDDIIDTGGTIAKAAEILKS 235

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 688553852  242 AGAIKVYAILTHGIFSGPAISRINNANFEAVVVTNTIPQEdkiKHCSKIQVIDISMILAEAIRRTHNGESVSYLFS 317
Cdd:TIGR01251 236 AGAKRVIAAATHGVFSGPAIERIANAGVEEVIVTNTIPHE---KHKPKVSVISVAPLIAEAIRRIHNNESVSSLFD 308
Pribosyltran_N pfam13793
N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found ...
 4-120 3.87e-73

N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found N-terminal to the Pribosyltran, pfam00156.


Pssm-ID: 433483 [Multi-domain]  Cd Length: 117  Bit Score: 221.14  E-value: 3.87e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553852    4 IKIFSGSSHPDLSQKIADRLGLELGKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEINDNLMELLIMINACKIASAS 83
Cdd:pfam13793   1 LKIFSGNSNPELAEKIAKRLGIPLGKATVSRFSDGEIYVRIEESVRGKDVFIIQSTCPPVNDNLMELLIMIDALKRASAK 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 688553852   84 RVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAG 120
Cdd:pfam13793  81 RITAVIPYFGYARQDRKDKPREPITAKLVADLLEAAG 117
PRTases_typeI cd06223
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ...
 147-277 1.76e-21

Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.


Pssm-ID: 206754 [Multi-domain]  Cd Length: 130  Bit Score: 88.22  E-value: 1.76e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553852 147 AEPAVLKWIKENIneWKNCTIVSPDAGGAKRcggVTSIADRLNVDFALIHKERKKANEVDRM------VLVGDVKDRVAI 220
Cdd:cd06223    1 AGRLLAEEIREDL--LEPDVVVGILRGGLPL---AAALARALGLPLAFIRKERKGPGRTPSEpyglelPLGGDVKGKRVL 75

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 688553852 221 LVDDMADTCGTVCHAADKLVSAGAIKVYAILTHGIFSGPAisRINNANFEAVVVTNT 277
Cdd:cd06223   76 LVDDVIATGGTLLAAIELLKEAGAKVVGVAVLLDKPEGGA--RELASPGDPVYSLFT 130
 
Name Accession Description Interval E-value
PrsA COG0462
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; ...
 1-317 2.95e-173

Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; Phosphoribosylpyrophosphate synthetase is part of the Pathway/BioSystem: Histidine biosynthesis, Purine biosynthesis


Pssm-ID: 440230 [Multi-domain]  Cd Length: 311  Bit Score: 482.25  E-value: 2.95e-173
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553852   1 MPNIKIFSGSSHPDLSQKIADRLGLELGKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEINDNLMELLIMINACKIA 80
Cdd:COG0462    1 MKDLKIFSGNANPELAEEIAEYLGVPLGKAEVRRFSDGEIYVRIEESVRGRDVFVIQSTSPPVNDNLMELLIMIDALKRA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553852  81 SASRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIKEniN 160
Cdd:COG0462   81 SARRITAVIPYYGYARQDRKFRPREPITAKLVADLLEAAGADRVLTVDLHAPQIQGFFDIPVDHLYAAPLLADYIKS--K 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553852 161 EWKNCTIVSPDAGGAKRcggVTSIADRLNVDFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTVCHAADKLV 240
Cdd:COG0462  159 DLEDLVVVSPDVGGVKR---ARAFAKRLGAPLAIIDKRRPGANEVEVMNIIGDVEGKTCIIVDDMIDTGGTLVEAAEALK 235

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 688553852 241 SAGAIKVYAILTHGIFSGPAISRINNANFEAVVVTNTIPQEDKiKHCSKIQVIDISMILAEAIRRTHNGESVSYLFS 317
Cdd:COG0462  236 EAGAKSVYAAATHGVLSGPAVERLENSPIDELVVTDTIPLPEE-KRCDKIKVLSVAPLLAEAIRRIHEGESVSSLFD 311
PRK01259 PRK01259
ribose-phosphate diphosphokinase;
4-316 1.31e-162

ribose-phosphate diphosphokinase;


Pssm-ID: 234929 [Multi-domain]  Cd Length: 309  Bit Score: 455.35  E-value: 1.31e-162
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553852   4 IKIFSGSSHPDLSQKIADRLGLELGKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEINDNLMELLIMINACKIASAS 83
Cdd:PRK01259   1 MKLFAGNANPELAEKIAKYLGIPLGKASVGRFSDGEISVEINENVRGKDVFIIQSTCAPTNDNLMELLIMIDALKRASAG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553852  84 RVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIKEniNEWK 163
Cdd:PRK01259  81 RITAVIPYFGYARQDRKARSRVPITAKLVANLLETAGADRVLTMDLHADQIQGFFDIPVDNLYGSPILLEDIKQ--KNLE 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553852 164 NCTIVSPDAGGAKRcggVTSIADRLNVDFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTVCHAADKLVSAG 243
Cdd:PRK01259 159 NLVVVSPDVGGVVR---ARALAKRLDADLAIIDKRRPRANVSEVMNIIGDVEGRDCILVDDMIDTAGTLCKAAEALKERG 235

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 688553852 244 AIKVYAILTHGIFSGPAISRINNANFEAVVVTNTIPQEDKIKHCSKIQVIDISMILAEAIRRTHNGESVSYLF 316
Cdd:PRK01259 236 AKSVYAYATHPVLSGGAIERIENSVIDELVVTDSIPLSEEAKKCDKIRVLSVAPLLAEAIRRISNEESVSSLF 308
ribP_PPkin TIGR01251
ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In ...
 4-317 1.84e-154

ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In some systems, close homologs lacking enzymatic activity exist and perform regulatory functions. The model is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 273523 [Multi-domain]  Cd Length: 308  Bit Score: 434.78  E-value: 1.84e-154
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553852    4 IKIFSGSSHPDLSQKIADRLGLELGKVVTKKFSNQETCVEIGESVRGEDVYIV-QSGCGEINDNLMELLIMINACKIASA 82
Cdd:TIGR01251   1 MKIFSGSSNQELAQKVAKNLGLPLGDVEVKRFPDGELYVRINESVRGKDVFIIqQSTSAPVNDNLMELLIMIDALKRASA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553852   83 SRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIKENIneW 162
Cdd:TIGR01251  81 KSITAVIPYYGYARQDKKFKSREPISAKLVANLLETAGADRVLTVDLHSPQIQGFFDVPVDNLYASPVLAEYLKKKI--L 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553852  163 KNCTIVSPDAGGAKRcggVTSIADRLNVDFALIHKERK-KANEVDRMVLVGDVKDRVAILVDDMADTCGTVCHAADKLVS 241
Cdd:TIGR01251 159 DNPVVVSPDAGGVER---AKKVADALGCPLAIIDKRRIsATNEVEVMNLVGDVEGKDVVIVDDIIDTGGTIAKAAEILKS 235

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 688553852  242 AGAIKVYAILTHGIFSGPAISRINNANFEAVVVTNTIPQEdkiKHCSKIQVIDISMILAEAIRRTHNGESVSYLFS 317
Cdd:TIGR01251 236 AGAKRVIAAATHGVFSGPAIERIANAGVEEVIVTNTIPHE---KHKPKVSVISVAPLIAEAIRRIHNNESVSSLFD 308
PLN02369 PLN02369
ribose-phosphate pyrophosphokinase
 13-316 1.64e-113

ribose-phosphate pyrophosphokinase


Pssm-ID: 215209 [Multi-domain]  Cd Length: 302  Bit Score: 330.50  E-value: 1.64e-113
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553852  13 PDLSQKIADRLGLELGKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEINDNLMELLIMINACKIASASRVTAVIPCF 92
Cdd:PLN02369   1 PALSQEIACYLGLELGKITIKRFADGEIYVQLQESVRGCDVFLVQPTCPPANENLMELLIMIDACRRASAKRITAVIPYF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553852  93 PYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIKENINEWKNCTIVSPDA 172
Cdd:PLN02369  81 GYARADRKTQGRESIAAKLVANLITEAGADRVLACDLHSGQSMGYFDIPVDHVYGQPVILDYLASKTISSPDLVVVSPDV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553852 173 GGAKRcggVTSIADRL-NVDFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTVCHAADKLVSAGAIKVYAIL 251
Cdd:PLN02369 161 GGVAR---ARAFAKKLsDAPLAIVDKRRQGHNVAEVMNLIGDVKGKVAIMVDDMIDTAGTITKGAALLHQEGAREVYACA 237

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 688553852 252 THGIFSGPAISRINNANFEAVVVTNTIPQEDKiKHCSKIQVIDISMILAEAIRRTHNGESVSYLF 316
Cdd:PLN02369 238 THAVFSPPAIERLSSGLFQEVIVTNTIPVSEK-NYFPQLTVLSVANLLGETIWRVHDDCSVSSIF 301
PRK04923 PRK04923
ribose-phosphate diphosphokinase;
2-316 1.54e-110

ribose-phosphate diphosphokinase;


Pssm-ID: 179893 [Multi-domain]  Cd Length: 319  Bit Score: 323.80  E-value: 1.54e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553852   2 PNIKIFSGSSHPDLSQKIADRLGLELGKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEINDNLMELLIMINACKIAS 81
Cdd:PRK04923   5 RNLLVFSGNANKPLAQSICKELGVRMGKALVTRFSDGEVQVEIEESVRRQEVFVIQPTCAPSAENLMELLVLIDALKRAS 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553852  82 ASRVTAVIPCFPYARQDKKDKS-RAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIkenin 160
Cdd:PRK04923  85 AASVTAVIPYFGYSRQDRRMRSsRVPITAKVAAKMISAMGADRVLTVDLHADQIQGFFDVPVDNVYASPLLLADI----- 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553852 161 eWK-----NCTIVSPDAGGAKRcggVTSIADRL-NVDFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTVCH 234
Cdd:PRK04923 160 -WRaygtdNLIVVSPDVGGVVR---ARAVAKRLdDADLAIIDKRRPRANVATVMNIIGDVQGKTCVLVDDLVDTAGTLCA 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553852 235 AADKLVSAGAIKVYAILTHGIFSGPAISRINNANFEAVVVTNTIPQEDKIKHCSKIQVIDISMILAEAIRRTHNGESVSY 314
Cdd:PRK04923 236 AAAALKQRGALKVVAYITHPVLSGPAVDNINNSQLDELVVTDTIPLSEAARACAKIRQLSVAELLAETIRRIAFGESVSS 315


                 ..
gi 688553852 315 LF 316
Cdd:PRK04923 316 LY 317
PRK02812 PRK02812
ribose-phosphate pyrophosphokinase; Provisional
 4-316 2.66e-110

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 235072 [Multi-domain]  Cd Length: 330  Bit Score: 323.62  E-value: 2.66e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553852   4 IKIFSGSSHPDLSQKIADRLGLELGKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEINDNLMELLIMINACKIASAS 83
Cdd:PRK02812  22 LRLFSGSSNPALAQEVARYLGMDLGPMIRKRFADGELYVQIQESIRGCDVYLIQPTCAPVNDHLMELLIMVDACRRASAR 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553852  84 RVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIKEniNEWK 163
Cdd:PRK02812 102 QITAVIPYYGYARADRKTAGRESITAKLVANLITKAGADRVLAMDLHSAQIQGYFDIPCDHVYGSPVLLDYLAS--KNLE 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553852 164 NCTIVSPDAGGAKRcggVTSIADRLN-VDFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTVCHAADKLVSA 242
Cdd:PRK02812 180 DIVVVSPDVGGVAR---ARAFAKKLNdAPLAIIDKRRQAHNVAEVLNVIGDVKGKTAILVDDMIDTGGTICEGARLLRKE 256

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 688553852 243 GAIKVYAILTHGIFSGPAISRINNANFEAVVVTNTIPQEDKiKHCSKIQVIDISMILAEAIRRTHNGESVSYLF 316
Cdd:PRK02812 257 GAKQVYACATHAVFSPPAIERLSSGLFEEVIVTNTIPVPEE-RRFPQLKVLSVANMLGEAIWRIHEESSVSSMF 329
PRK02269 PRK02269
ribose-phosphate diphosphokinase;
3-316 2.78e-109

ribose-phosphate diphosphokinase;


Pssm-ID: 167353 [Multi-domain]  Cd Length: 320  Bit Score: 320.59  E-value: 2.78e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553852   3 NIKIFSGSSHPDLSQKIADRLGLELGKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEINDNLMELLIMINACKIASA 82
Cdd:PRK02269   5 DLKLFALSSNKELAEKVAQEIGIELGKSSVRQFSDGEIQVNIEESIRGHHVFILQSTSSPVNDNLMEILIMVDALKRASA 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553852  83 SRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIKENINEW 162
Cdd:PRK02269  85 ESINVVMPYYGYARQDRKARSREPITSKLVANMLEVAGVDRLLTVDLHAAQIQGFFDIPVDHLMGAPLIADYFDRRGLVG 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553852 163 KNCTIVSPDAGGAKRcggVTSIADRLNVDFALIHKERK--KANEVDRMVLVGDVKDRVAILVDDMADTCGTVCHAADKLV 240
Cdd:PRK02269 165 DDVVVVSPDHGGVTR---ARKLAQFLKTPIAIIDKRRSvdKMNTSEVMNIIGNVKGKKCILIDDMIDTAGTICHAADALA 241

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 688553852 241 SAGAIKVYAILTHGIFSGPAISRINNANFEAVVVTNTI--PQEdkiKHCSKIQVIDISMILAEAIRRTHNGESVSYLF 316
Cdd:PRK02269 242 EAGATEVYASCTHPVLSGPALDNIQKSAIEKLVVLDTIylPEE---RLIDKIEQISIADLLGEAIIRIHEKRPLSPLF 316
PTZ00145 PTZ00145
phosphoribosylpyrophosphate synthetase; Provisional
 1-316 4.50e-109

phosphoribosylpyrophosphate synthetase; Provisional


Pssm-ID: 240290 [Multi-domain]  Cd Length: 439  Bit Score: 324.52  E-value: 4.50e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553852   1 MPNIKIFSGSSHPDLSQKIADRLGLELGKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEINDNLMELLIMINACKIA 80
Cdd:PTZ00145 117 MENAILFSGSSNPLLSKNIADHLGTILGRVHLKRFADGEVSMQFLESIRGKDVYIIQPTCPPVNENLIELLLMISTCRRA 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553852  81 SASRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFD--IPVDNLYAEPAVLKWIKEn 158
Cdd:PTZ00145 197 SAKKITAVIPYYGYARQDRKLSSRVPISAADVARMIEAMGVDRVVAIDLHSGQIQGFFGprVPVDNLEAQLIGLDYFTK- 275

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553852 159 iNEWKNCTIVSPDAGGAKRcggVTSIADRLN------VDFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTV 232
Cdd:PTZ00145 276 -KDLYKPVIVSPDAGGVYR---ARKFQDGLNhrgisdCGIAMLIKQRTKPNEIEKMDLVGNVYDSDVIIVDDMIDTSGTL 351

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553852 233 CHAADKLVSAGAIKVYAILTHGIFSGPAISRINNANFEAVVVTNTIPQEDKIKHCSKIQVIDISMILAEAIRRTHNGESV 312
Cdd:PTZ00145 352 CEAAKQLKKHGARRVFAFATHGLFSGPAIERIEASPLEEVVVTDTVKSNKNIDSCKKITKLSVSVLVADAIRRIHQKESL 431


                 ....
gi 688553852 313 SYLF 316
Cdd:PTZ00145 432 NDLF 435
PRK03092 PRK03092
ribose-phosphate diphosphokinase;
15-316 5.45e-109

ribose-phosphate diphosphokinase;


Pssm-ID: 179535 [Multi-domain]  Cd Length: 304  Bit Score: 319.20  E-value: 5.45e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553852  15 LSQKIADRLGLELGKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEINDNLMELLIMINACKIASASRVTAVIPCFPY 94
Cdd:PRK03092   1 LAEEVAKELGVEVTPTTAYDFANGEIYVRFEESVRGCDAFVLQSHTAPINKWLMEQLIMIDALKRASAKRITVVLPFYPY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553852  95 ARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIKENINEwKNCTIVSPDAGG 174
Cdd:PRK03092  81 ARQDKKHRGREPISARLVADLFKTAGADRIMTVDLHTAQIQGFFDGPVDHLFAMPLLADYVRDKYDL-DNVTVVSPDAGR 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553852 175 AKrcggVTSI-ADRL-NVDFALIHKER--KKANEVDRMVLVGDVKDRVAILVDDMADTCGTVCHAADKLVSAGAIKVYAI 250
Cdd:PRK03092 160 VR----VAEQwADRLgGAPLAFIHKTRdpTVPNQVVANRVVGDVEGRTCVLVDDMIDTGGTIAGAVRALKEAGAKDVIIA 235

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 688553852 251 LTHGIFSGPAISRINNANFEAVVVTNTIPQEDKiKHCSKIQVIDISMILAEAIRRTHNGESVSYLF 316
Cdd:PRK03092 236 ATHGVLSGPAAERLKNCGAREVVVTDTLPIPEE-KRFDKLTVLSIAPLLARAIREVFEDGSVTSLF 300
PRK02458 PRK02458
ribose-phosphate pyrophosphokinase; Provisional
 2-320 5.88e-94

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 235039 [Multi-domain]  Cd Length: 323  Bit Score: 281.63  E-value: 5.88e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553852   2 PNIKIFSGSSHPDLSQKIADRLGLELGKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEINDNLMELLIMINACKIAS 81
Cdd:PRK02458   8 KQIKLFSLNSNLEIAEKIAQAAGVPLGKLSSRQFSDGEIMINIEESVRGDDIYIIQSTSFPVNDHLWELLIMIDACKRAS 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553852  82 ASRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIKENINE 161
Cdd:PRK02458  88 ANTVNVVLPYFGYARQDRIAKPREPITAKLVANMLVKAGVDRVLTLDLHAVQVQGFFDIPVDNLFTVPLFAKHYCKKGLS 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553852 162 WKNCTIVSPDAGGAKRcggVTSIADRLNVDFALIHKERKKANEVDRMVlVGDVKDRVAILVDDMADTCGTVCHAADKLVS 241
Cdd:PRK02458 168 GSDVVVVSPKNSGIKR---ARSLAEYLDAPIAIIDYAQDDSEREEGYI-IGDVAGKKAILIDDILNTGKTFAEAAKIVER 243

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 688553852 242 AGAIKVYAILTHGIFSGPAISRINNANFEAVVVTNTIPQEDKIKhcSKIQVIDISMILAEAIRRTHNGESVSYLFSHVP 320
Cdd:PRK02458 244 EGATEIYAVASHGLFAGGAAEVLENAPIKEILVTDSVATKERVP--KNVTYLSASELIADAIIRIHERKPLSPLFAYNK 320
PRK00553 PRK00553
ribose-phosphate pyrophosphokinase; Provisional
 6-317 4.73e-82

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 179062 [Multi-domain]  Cd Length: 332  Bit Score: 251.76  E-value: 4.73e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553852   6 IFSGSSHPDLSQKIADRLGLELGKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEINDNLMELLIMINACKIASASRV 85
Cdd:PRK00553  12 IFSLSKAKKLVDSICRKLSMKPGEIVIQKFADGETYIRFDESVRNKDVVIFQSTCSPVNDSLMELLIAIDALKRGSAKSI 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553852  86 TAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIKEnINEWKNC 165
Cdd:PRK00553  92 TAILPYYGYARQDRKTAGREPITSKLVADLLTKAGVTRVTLTDIHSDQTQGFFDIPVDILRTYHVFLSRVLE-LLGKKDL 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553852 166 TIVSPDAGGAKRcggVTSIADRLNVDFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTVCHAADKLVSAGAI 245
Cdd:PRK00553 171 VVVSPDYGGVKR---ARLIAESLELPLAIIDKRRPKHNVAESINVLGEVKNKNCLIVDDMIDTGGTVIAAAKLLKKQKAK 247

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 688553852 246 KVYAILTHGIFSGPAISRINNANFEAVV----VTNTIPQEdKIKHCSKIQVIDISMILAEAIRRTHNGESVSYLFS 317
Cdd:PRK00553 248 KVCVMATHGLFNKNAIQLFDEAFKKKLIdklfVSNSIPQT-KFEKKPQFKVVDLAHLYEEVLLCYANGGSISAIYT 322
Pribosyltran_N pfam13793
N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found ...
 4-120 3.87e-73

N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found N-terminal to the Pribosyltran, pfam00156.


Pssm-ID: 433483 [Multi-domain]  Cd Length: 117  Bit Score: 221.14  E-value: 3.87e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553852    4 IKIFSGSSHPDLSQKIADRLGLELGKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEINDNLMELLIMINACKIASAS 83
Cdd:pfam13793   1 LKIFSGNSNPELAEKIAKRLGIPLGKATVSRFSDGEIYVRIEESVRGKDVFIIQSTCPPVNDNLMELLIMIDALKRASAK 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 688553852   84 RVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAG 120
Cdd:pfam13793  81 RITAVIPYFGYARQDRKDKPREPITAKLVADLLEAAG 117
PRK00934 PRK00934
ribose-phosphate pyrophosphokinase; Provisional
 5-305 1.77e-63

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 234868 [Multi-domain]  Cd Length: 285  Bit Score: 202.45  E-value: 1.77e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553852   5 KIFSGSSHPDLSQKIADRLGLELGKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEiNDNLMELLIMINACKIASASR 84
Cdd:PRK00934   1 MIIGGSASQLLASEVARLLNTELALVETKRFPDGELYVRILGEIDGEDVVIISTTYPQ-DENLVELLLLIDALRDEGAKS 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553852  85 VTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGaDHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIKENINewkN 164
Cdd:PRK00934  80 ITLVIPYLGYARQDKRFKPGEPISARAIAKIISAYY-DRIITINIHEPSILEFFPIPFINLDAAPLIAEYIGDKLD---D 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553852 165 CTIVSPDAGGAKRcggVTSIADRLNVDFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTVCHAADKLVSAGA 244
Cdd:PRK00934 156 PLVLAPDKGALEL---AKEAAEILGCEYDYLEKTRISPTEVEIAPKNLDVKGKDVLIVDDIISTGGTMATAIKILKEQGA 232

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 688553852 245 IKVYAILTHGIFSGPAISRINNANFEAVVVTNTIPqedkikhcSKIQVIDISMILAEAIRR 305
Cdd:PRK00934 233 KKVYVACVHPVLVGDAILKLYNAGVDEIIVTDTLE--------SEVSKISVAPLIADLLKK 285
Pribosyl_synth pfam14572
Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes ...
 161-316 2.03e-43

Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes from class EC:2.7.6.1, phosphoribosyl-pyrophosphate transferase.


Pssm-ID: 434046  Cd Length: 184  Bit Score: 147.27  E-value: 2.03e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553852  161 EWKNCTIVSPDAGGAKRcggVTSIADRLNVDFALIHKERKKA--NEVDR----------------------------MVL 210
Cdd:pfam14572   1 DYRNAVIVARSPGSAKR---ATSFAERLRLGIAVIHGEQKEAesDEVDGrqspppyrsrtvsrslglpeiipkekppMTV 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553852  211 VGDVKDRVAILVDDMADTCGTVCHAADKLVSAGAIKVYAILTHGIFSGPAISRINNANFEAVVVTNTIPQEDKIKHCSKI 290
Cdd:pfam14572  78 VGDVGGRIAIIVDDMIDDVDSFVAAAELLKERGAYKIYVMATHGLLSSDAPRLLEASPIDEVVVTNTIPHEIQKMQCHKI 157

                         170       180
                  ....*....|....*....|....*.
gi 688553852  291 QVIDISMILAEAIRRTHNGESVSYLF 316
Cdd:pfam14572 158 KTIDISQLIAEAIRRIHNGESMSYLF 183
PRK07199 PRK07199
ribose-phosphate diphosphokinase;
14-305 2.09e-42

ribose-phosphate diphosphokinase;


Pssm-ID: 235960 [Multi-domain]  Cd Length: 301  Bit Score: 148.55  E-value: 2.09e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553852  14 DLSQKIADRLGLELGKVVTKKFSNQETCVEIGESVRGEDVYIVQSgCGEINDNLMELLIMINACKIASASRVTAVIPCFP 93
Cdd:PRK07199  13 AAAGRLAAALGVEVGRIELHRFPDGESYVRLDSPVAGRTVVLVCS-LDRPDEKLLPLLFAAEAARELGARRVGLVAPYLA 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553852  94 YARQDKKDKSRAPISAKLVANMLSvAGADHIITMD--LH-ASQIQGFFDIPVDNLYAEPAVLKWIKENINEWkncTIVSP 170
Cdd:PRK07199  92 YMRQDIAFHPGEAISQRHFARLLS-GSFDRLVTVDphLHrYPSLSEVYPIPAVVLSAAPAIAAWIRAHVPRP---LLIGP 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553852 171 DAGGAKRcggVTSIADRLNVDFALIHKERKKANEVDrmVLVGDV---KDRVAILVDDMADTCGTVCHAADKLVSAGAIKV 247
Cdd:PRK07199 168 DEESEQW---VAAVAERAGAPHAVLRKTRHGDRDVE--ISLPDAapwAGRTPVLVDDIVSTGRTLIEAARQLRAAGAASP 242

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 688553852 248 YAILTHGIFSGPAISRINNANFEAVVVTNTIPqedkikHCSkiQVIDISMILAEAIRR 305
Cdd:PRK07199 243 DCVVVHALFAGDAYSALAAAGIARVVSTDTVP------HPS--NAISLAPLLAEALRR 292
PRK06827 PRK06827
phosphoribosylpyrophosphate synthetase; Provisional
 29-315 1.53e-37

phosphoribosylpyrophosphate synthetase; Provisional


Pssm-ID: 180714 [Multi-domain]  Cd Length: 382  Bit Score: 137.39  E-value: 1.53e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553852  29 KVVTKKFSNQETCVEIGESVRGEDVYIVQ---------SGCGE-----INDNLMELLIMINACKiASASRVTAVIPCFPY 94
Cdd:PRK06827  56 PAKFIRFSNGEAKGEILESVRGKDIYILQdvgnysvtyNMFGEknhmsPDDHFQDLKRTIDAIR-GKARRITVIMPFLYE 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553852  95 ARQDKKdKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDI-PVDNLYAEPAVLKWIKENINE----WKNCTIVS 169
Cdd:PRK06827 135 SRQHKR-KGRESLDCALALQELEELGVDNIITFDAHDPRIENAIPLmGFENLYPSYQIIKALLKNEKDleidKDHLMVIS 213

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553852 170 PDAGGAKRcggVTSIADRLNVDFALIHKERK-------KANEVDRMVLVGDVKDRVAILVDDMADTCGTVCHAADKLVSA 242
Cdd:PRK06827 214 PDTGAMDR---AKYYASVLGVDLGLFYKRRDysrvvngRNPIVAHEFLGRDVEGKDVLIVDDMIASGGSMIDAAKELKSR 290

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 688553852 243 GAIKVYAILTHGIFSGpAISRINNAN----FEAVVVTNTIPQEDKIKHCSKIQVIDISMILAEAIRRTHNGESVSYL 315
Cdd:PRK06827 291 GAKKIIVAATFGFFTN-GLEKFDKAYeegyFDRIIGTNLVYHPEELLSKPWYIEVDMSKLIARIIDALNHDVSLSKL 366
PRTases_typeI cd06223
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ...
 147-277 1.76e-21

Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.


Pssm-ID: 206754 [Multi-domain]  Cd Length: 130  Bit Score: 88.22  E-value: 1.76e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553852 147 AEPAVLKWIKENIneWKNCTIVSPDAGGAKRcggVTSIADRLNVDFALIHKERKKANEVDRM------VLVGDVKDRVAI 220
Cdd:cd06223    1 AGRLLAEEIREDL--LEPDVVVGILRGGLPL---AAALARALGLPLAFIRKERKGPGRTPSEpyglelPLGGDVKGKRVL 75

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 688553852 221 LVDDMADTCGTVCHAADKLVSAGAIKVYAILTHGIFSGPAisRINNANFEAVVVTNT 277
Cdd:cd06223   76 LVDDVIATGGTLLAAIELLKEAGAKVVGVAVLLDKPEGGA--RELASPGDPVYSLFT 130
PLN02297 PLN02297
ribose-phosphate pyrophosphokinase
 3-280 4.50e-09

ribose-phosphate pyrophosphokinase


Pssm-ID: 177934 [Multi-domain]  Cd Length: 326  Bit Score: 56.62  E-value: 4.50e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553852   3 NIKIFSGSSHPDLSQKIADRLG-LELGKVVTKKFSNQETCVEIG--ESVRGEDVYIVQSGcgEINDNLMELLIMINACKI 79
Cdd:PLN02297  16 QVHLFYCEETEELARKIAAESDaIELGSINWRKFPDGFPNLFINnaHGIRGQHVAFLASF--SSPAVIFEQLSVIYALPK 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553852  80 ASASRVTAVIPCFP---YAR-QDKKDKSRAPISAKLVANM-LSVAGADHIITMDLHASQIQGFFDIPVDNLYAE--PAVL 152
Cdd:PLN02297  94 LFVASFTLVLPFFPtgtSERvEREGDVATAFTLARILSNIpISRGGPTSLVIFDIHALQERFYFGDNVLPCFESgiPLLK 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553852 153 KWIKEnINEWKNCTIVSPDAGGAKRcggvtsiadrlnvdfalIHKERKKANEV---------DRMVLV--GDVKDRVAIL 221
Cdd:PLN02297 174 KRLQQ-LPDSDNIVIAFPDDGAWKR-----------------FHKQFEHFPMVvctkvregdKRIVRIkeGNPAGRHVVI 235

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 688553852 222 VDDMADTCGTVCHAADKLVSAGAIKVYAILTHGIFSGPAISRINNAN------FEAVVVTNTIPQ 280
Cdd:PLN02297 236 VDDLVQSGGTLIECQKVLAAHGAAKVSAYVTHGVFPNESWERFTHDNggpeagFAYFWITDSCPQ 300
Pribosyltran pfam00156
Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl ...
 141-247 2.65e-06

Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl transferase enzymes. This family includes: Adenine phosphoribosyl-transferase EC:2.4.2.7. Hypoxanthine-guanine-xanthine phosphoribosyl-transferase. Hypoxanthine phosphoribosyl-transferase EC:2.4.2.8. Ribose-phosphate pyrophosphokinase i EC:2.7.6.1. Amidophosphoribosyltransferase EC:2.4.2.14. Orotate phosphoribosyl-transferase EC:2.4.2.10. Uracil phosphoribosyl-transferase EC:2.4.2.9. Xanthine-guanine phosphoribosyl-transferase EC:2.4.2.22. In Arabidopsis, At the very N-terminus of this domain is the P-Loop NTPase domain.


Pssm-ID: 425489 [Multi-domain]  Cd Length: 150  Bit Score: 46.59  E-value: 2.65e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553852  141 PVDNLYAEPAVLKWIKE---NINE---WKNCTIVSPDAGGAKRcggVTSIADRLNVDFALIHKERKKAN---EVDRMVLV 211
Cdd:pfam00156   1 SVDEILDNPAILKAVARlaaQINEdygGKPDVVVGILRGGLPF---AGILARRLDVPLAFVRKVSYNPDtseVMKTSSAL 77

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 688553852  212 GDVKDRVAILVDDMADTCGTVCHAADKLVSAGAIKV 247
Cdd:pfam00156  78 PDLKGKTVLIVDDILDTGGTLLKVLELLKNVGPKEV 113
PyrE COG0461
Orotate phosphoribosyltransferase [Nucleotide transport and metabolism]; Orotate ...
 181-276 5.33e-03

Orotate phosphoribosyltransferase [Nucleotide transport and metabolism]; Orotate phosphoribosyltransferase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440229  Cd Length: 201  Bit Score: 37.44  E-value: 5.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553852 181 VTSIADRLNVDFALIhkeRKKANEVDRM-VLVGDVK--DRVAIlVDDMADTCGTVCHAADKLVSAGA--IKVYAILTHGi 255
Cdd:COG0461   78 AAAVARALGLPAIFV---RKEAKDHGTGgQIEGGLLpgERVLV-VEDVITTGGSVLEAVEALREAGAevVGVAVIVDRE- 152

                         90       100
                 ....*....|....*....|.
gi 688553852 256 fsGPAISRINNANFEAVVVTN 276
Cdd:COG0461  153 --EGAAENLEEAGVPLHSLLT 171
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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