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Conserved domains on  [gi|688566999|ref|XP_009302077|]
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glutamate--cysteine ligase regulatory subunit isoform X1 [Danio rerio]

Protein Classification

aldo-keto reductase family protein( domain architecture ID 305)

aldo-keto reductase family protein may be an NAD(P)(H) oxidoreductase that reduces aldehydes and ketones to primary and secondary alcohols

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AKR_SF super family cl00470
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of ...
 85-214 1.13e-12

Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications. Members have very distinct functions and include the prokaryotic 2,5-diketo-D-gluconic acid reductases and beta-keto ester reductases, the eukaryotic aldose reductases, aldehyde reductases, hydroxysteroid dehydrogenases, steroid 5beta-reductases, potassium channel beta-subunits, and aflatoxin aldehyde reductases, among others.


The actual alignment was detected with superfamily member cd19071:

Pssm-ID: 444925 [Multi-domain]  Cd Length: 251  Bit Score: 65.97  E-value: 1.13e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688566999  85 REELKVSVKLFLTEWDCSSIRSAVDMACLSLGVSQLDSVIIAPPSLPEGESQTLTHLQpLWQELESLVQSQKIAAIGTSD 164
Cdd:cd19071   54 REELFITTKLWPTDHGYERVREALEESLKDLGLDYLDLYLIHWPVPGKEGGSKEARLE-TWRALEELVDEGLVRSIGVSN 132

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 688566999 165 LDKTLLEQLYNWAqQIKPSSNQVNLASCCVmPPDLTAFAKEFDIQLLTHS 214
Cdd:cd19071  133 FNVEHLEELLAAA-RIKPAVNQIELHPYLQ-QKELVEFCKEHGIVVQAYS 180
 
Name Accession Description Interval E-value
AKR_AKR1-5-like cd19071
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases ...
 85-214 1.13e-12

AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.


Pssm-ID: 381297 [Multi-domain]  Cd Length: 251  Bit Score: 65.97  E-value: 1.13e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688566999  85 REELKVSVKLFLTEWDCSSIRSAVDMACLSLGVSQLDSVIIAPPSLPEGESQTLTHLQpLWQELESLVQSQKIAAIGTSD 164
Cdd:cd19071   54 REELFITTKLWPTDHGYERVREALEESLKDLGLDYLDLYLIHWPVPGKEGGSKEARLE-TWRALEELVDEGLVRSIGVSN 132

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 688566999 165 LDKTLLEQLYNWAqQIKPSSNQVNLASCCVmPPDLTAFAKEFDIQLLTHS 214
Cdd:cd19071  133 FNVEHLEELLAAA-RIKPAVNQIELHPYLQ-QKELVEFCKEHGIVVQAYS 180
Aldo_ket_red pfam00248
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ...
 82-214 1.29e-04

Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.


Pssm-ID: 425554 [Multi-domain]  Cd Length: 290  Bit Score: 42.68  E-value: 1.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688566999   82 PEEREELKVSVKL-FLTEWDCSSIRSAVDMACLS-----LGVSQLDSVIIA--PPSLPEGEsqtlthlqpLWQELESLVQ 153
Cdd:pfam00248  58 PVKRDKVVIATKVpDGDGPWPSGGSKENIRKSLEeslkrLGTDYIDLYYLHwpDPDTPIEE---------TWDALEELKK 128

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 688566999  154 SQKIAAIGTSDLDKTLLEQLYNWAqQIKPSSNQVNLASCCVMPP-DLTAFAKEFDIQLLTHS 214
Cdd:pfam00248 129 EGKIRAIGVSNFDAEQIEKALTKG-KIPIVAVQVEYNLLRRRQEeELLEYCKKNGIPLIAYS 189
 
Name Accession Description Interval E-value
AKR_AKR1-5-like cd19071
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases ...
 85-214 1.13e-12

AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.


Pssm-ID: 381297 [Multi-domain]  Cd Length: 251  Bit Score: 65.97  E-value: 1.13e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688566999  85 REELKVSVKLFLTEWDCSSIRSAVDMACLSLGVSQLDSVIIAPPSLPEGESQTLTHLQpLWQELESLVQSQKIAAIGTSD 164
Cdd:cd19071   54 REELFITTKLWPTDHGYERVREALEESLKDLGLDYLDLYLIHWPVPGKEGGSKEARLE-TWRALEELVDEGLVRSIGVSN 132

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 688566999 165 LDKTLLEQLYNWAqQIKPSSNQVNLASCCVmPPDLTAFAKEFDIQLLTHS 214
Cdd:cd19071  133 FNVEHLEELLAAA-RIKPAVNQIELHPYLQ-QKELVEFCKEHGIVVQAYS 180
AKR_AKR3C2-3 cd19120
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis ...
 85-214 2.79e-08

Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis NADPH-dependent conjugated polyketone reductase C2 (CPR), and similar proteins; Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase (EC 1.1.1.190/EC 1.1.1.191) and Candida parapsilosis NADPH-dependent CPR (EC 1.1.1.358/EC 1.1.1.168) are founding members of aldo-keto reductase family 3 member C2 (AKR3C2) and C3 (AKR3C3), respectively. Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase catalyzes the conversion from (Indol-3-yl)ethanol to (indol-3-yl)acetaldehyde in a NAD/NADP-dependent manner. CPR, also called 2-dehydropantolactone reductase, or 2-dehydropantolactone reductase (A-specific), or ketopantoyl-lactone reductase, acts as a NADPH-dependent conjugated polyketone reductase with broad substrate specificity and strict stereospecificity. It reduces ketopantoyl lactone and isatin.


Pssm-ID: 381346 [Multi-domain]  Cd Length: 269  Bit Score: 53.39  E-value: 2.79e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688566999  85 REELKVSVKLFLtewDCSSIRSAVDMACLSLGVSQLDSVII-APPSLPEGesqtLTHLQPLWQELESLVQSQKIAAIGTS 163
Cdd:cd19120   65 REDLFITTKVSP---GIKDPREALRKSLAKLGVDYVDLYLIhSPFFAKEG----GPTLAEAWAELEALKDAGLVRSIGVS 137

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 688566999 164 DLDKTLLEQLYNwAQQIKPSSNQVNLASCCVMP-PDLTAFAKEFDIQLLTHS 214
Cdd:cd19120  138 NFRIEDLEELLD-TAKIKPAVNQIEFHPYLYPQqPALLEYCREHGIVVSAYS 188
AKR_CeZK1290-like cd19135
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the ...
 85-209 4.87e-08

Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.


Pssm-ID: 381361 [Multi-domain]  Cd Length: 265  Bit Score: 52.71  E-value: 4.87e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688566999  85 REELKVSVKLFLTEWDCSSIRSAVDMACLSLGVSQLDSVIIAPPSLPEGESQTLTHLQPLWQELESLVQSQKIAAIGTSD 164
Cdd:cd19135   66 REDLFLTTKLWPSDYGYESTKQAFEASLKRLGVDYLDLYLLHWPDCPSSGKNVKETRAETWRALEELYDEGLCRAIGVSN 145

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 688566999 165 LDKTLLEQLYNWAqQIKPSSNQVNLaSCCVMPPDLTAFAKEFDIQ 209
Cdd:cd19135  146 FLIEHLEQLLEDC-SVVPHVNQVEF-HPFQNPVELIEYCRDNNIV 188
AKR_AKR4C1-15 cd19125
AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase ...
 85-187 2.33e-06

AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase (ALR) from Hordeum vulgare (AKR4C1), Bromus inermis (AKR4C2), Avena fatua (AKR4C3), and Xerophyta viscosa (AKR4C4), two aldose reductases, DpAR1 (AKR4C5) and DpAR2(AKR4C6), from Digitalis purpurea, aldehyde reductase from Zea mays (AKR4C7), four aldo-keto reductases from Arabidopsis thaliana (AKR4C8-11), and another three aldo-keto reductases from Aloe arborescens (AKR4C12) and Oryza sativa (AKR4C14/15). ALR (EC 1.1.1.21), also called AR, aldehyde reductase, or polyol dehydrogenase (NADP(+)), is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides. Both DpAR1 and DpAR2 reduce the ketone group of steroid structures. They may be involved in plant steroid metabolism in general and in cardenolide biosynthesis in particular. Plant aldo-keto reductases of the AKR4C subfamily play key roles during stress and are attractive targets for developing stress-tolerant crops.


Pssm-ID: 381351 [Multi-domain]  Cd Length: 287  Bit Score: 47.73  E-value: 2.33e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688566999  85 REELKVSVKLFLTEWDCSSIRSAVDMACLSLGVSQLDSVIIAPP-------SLPEGESQTLTHLQPLWQELESLVQSQKI 157
Cdd:cd19125   68 REDLFITSKLWCTDHAPEDVPPALEKTLKDLQLDYLDLYLIHWPvrlkkgaHMPEPEEVLPPDIPSTWKAMEKLVDSGKV 147

                         90       100       110
                 ....*....|....*....|....*....|
gi 688566999 158 AAIGTSDLDKTLLEQLYNWAqQIKPSSNQV 187
Cdd:cd19125  148 RAIGVSNFSVKKLEDLLAVA-RVPPAVNQV 176
AKR_AKR3D1 cd19121
AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, ...
 85-214 1.40e-05

AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, EC 1.1.1.365), also called D-galacturonic acid reductase, or GalUR, is a founding member of aldo-keto reductase family 3 member D1 (AKR3D1). It mediates the reduction of D-galacturonate to L-galactonate, the first step in D-galacturonate catabolic process. It also has activity with D-glucuronate and DL-glyceraldehyde. Its activity is seen only with NADPH and not with NADH.


Pssm-ID: 381347 [Multi-domain]  Cd Length: 279  Bit Score: 45.60  E-value: 1.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688566999  85 REELKVSVKLFLTEWDcsSIRSAVDMACLSLGVSQLD------SVIIAP-------PSLPEGES---QTLTHLQPlWQEL 148
Cdd:cd19121   68 REDLFVTTKLWSTYHR--RVELCLDRSLKSLGLDYVDlylvhwPVLLNPngnhdlfPTLPDGSRdldWDWNHVDT-WKQM 144

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 688566999 149 ESLVQSQKIAAIGTSDLDKTLLEQLYNWAQQIkPSSNQVNLASCCvmpP--DLTAFAKEFDIQLLTHS 214
Cdd:cd19121  145 EKVLKTGKTKAIGVSNYSIPYLEELLKHATVV-PAVNQVENHPYL---PqqELVDFCKEKGILIEAYS 208
Aldo_ket_red pfam00248
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ...
 82-214 1.29e-04

Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.


Pssm-ID: 425554 [Multi-domain]  Cd Length: 290  Bit Score: 42.68  E-value: 1.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688566999   82 PEEREELKVSVKL-FLTEWDCSSIRSAVDMACLS-----LGVSQLDSVIIA--PPSLPEGEsqtlthlqpLWQELESLVQ 153
Cdd:pfam00248  58 PVKRDKVVIATKVpDGDGPWPSGGSKENIRKSLEeslkrLGTDYIDLYYLHwpDPDTPIEE---------TWDALEELKK 128

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 688566999  154 SQKIAAIGTSDLDKTLLEQLYNWAqQIKPSSNQVNLASCCVMPP-DLTAFAKEFDIQLLTHS 214
Cdd:pfam00248 129 EGKIRAIGVSNFDAEQIEKALTKG-KIPIVAVQVEYNLLRRRQEeELLEYCKKNGIPLIAYS 189
AKR_AKR3E1 cd19122
AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol ...
 84-189 1.48e-04

AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol 2-dehydrogenase (GLD2, EC 1.1.1.156), also called dihydroxyacetone reductase, is a founding member of aldo-keto reductase family 3 member E1 (AKR3E1). It acts as a glycerol oxidoreductase probably involved in glycerol synthesis.


Pssm-ID: 381348 [Multi-domain]  Cd Length: 291  Bit Score: 42.22  E-value: 1.48e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688566999  84 EREELKVSVKLFLTEWDCSSIRSAVDMACLSLGVSQLDSVIIAPPSLPEGESQTLTHL----------------QPLWQE 147
Cdd:cd19122   68 KREDLFICTKVWNHLHEPEDVKWSIDNSLKNLKLDYIDLFLVHWPIAAEKNDQRSPKLgpdgkyvilkdltenpEPTWRA 147

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 688566999 148 LESLVQSQKIAAIGTSDLDKTLLEQLYNWAqQIKPSSNQVNL 189
Cdd:cd19122  148 MEEIYESGKAKAIGVSNWTIPGLKKLLSFA-KVKPHVNQIEI 188
AKR_AKR5B1 cd19127
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) ...
 84-189 1.77e-04

AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) is a founding member of the aldo-keto reductase family 5 member B1 (AKR5B1). M6DH (EC 1.1.1.218), also called naloxone reductase, oxidizes the C-6 hydroxy group of morphine and codeine.


Pssm-ID: 381353 [Multi-domain]  Cd Length: 268  Bit Score: 42.01  E-value: 1.77e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688566999  84 EREELKVSVKLFLTEWDCSSIRSAVDMACLSLGVSQLDSVIIAPPsLPEGESQTLTHlqplWQELESLVQSQKIAAIGTS 163
Cdd:cd19127   61 DRSDIFVTTKLWISDYGYDKALRGFDASLRRLGLDYVDLYLLHWP-VPNDFDRTIQA----YKALEKLLAEGRVRAIGVS 135

                         90       100
                 ....*....|....*....|....*.
gi 688566999 164 DLDKTLLEQLYNwAQQIKPSSNQVNL 189
Cdd:cd19127  136 NFTPEHLERLID-ATTVVPAVNQVEL 160
AKR_AKR5A_5G cd19126
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes ...
 85-210 1.82e-04

AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes prostaglandin F2-alpha synthase (PGFS) from Leishmania major (AKR5A1) and Trypanosoma brucei (AKR5A2). PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity for synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde. The AKR5G family of AKR includes Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase, which corresponds to aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.


Pssm-ID: 381352 [Multi-domain]  Cd Length: 254  Bit Score: 42.04  E-value: 1.82e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688566999  85 REELKVSVKLFLTEWDCSSIRSAVDMACLSLGVSQLDSVIIAPPsLPEGESQTlthlqplWQELESLVQSQKIAAIGTSD 164
Cdd:cd19126   63 REELFVTTKLWNDDQRARRTEDAFQESLDRLGLDYVDLYLIHWP-GKDKFIDT-------WKALEKLYASGKVKAIGVSN 134

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 688566999 165 LDKTLLEQLYNWAqQIKPSSNQVNLaSCCVMPPDLTAFAKEFDIQL 210
Cdd:cd19126  135 FQEHHLEELLAHA-DVVPAVNQVEF-HPYLTQKELRGYCKSKGIVV 178
AKR_BaDH-like cd19129
Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium ...
 85-187 2.24e-04

Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium diazoefficiens DH is the prototype of this family. It belongs to aldo/keto reductase family.


Pssm-ID: 381355 [Multi-domain]  Cd Length: 295  Bit Score: 41.67  E-value: 2.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688566999  85 REELKVSVKLFLTEWDCSSIRSAVDMACLSLGVSQLDSVIIAPP-SLPEGESQ------------TLTHLQPLWQELESL 151
Cdd:cd19129   63 REDLFVTTKLWNTNHRPERVKPAFEASLKRLQLDYLDLYLIHTPfAFQPGDEQdprdangnviydDGVTLLDTWRAMERL 142

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 688566999 152 VQSQKIAAIGTSDLDKTLLEQLYNwAQQIKPSSNQV 187
Cdd:cd19129  143 VDEGRCKAIGLSDVSLEKLREIFE-AARIKPAVVQV 177
AKR_AKR3F1-like cd19072
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime ...
 78-191 4.94e-04

Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase. Escherichia coli YeaE may act as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381298 [Multi-domain]  Cd Length: 263  Bit Score: 40.68  E-value: 4.94e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688566999  78 EAITPEEREELKVSVKL---FLTEWDCssIRSAvdMACLS-LGVSQLDSVII-AP-PSLPEGESqtlthlqplWQELESL 151
Cdd:cd19072   60 KAIKGFDREDLFITTKVspdHLKYDDV--IKAA--KESLKrLGTDYIDLYLIhWPnPSIPIEET---------LRAMEEL 126

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 688566999 152 VQSQKIAAIGTSDLDKTLLEQLYNWAQQIKPSSNQV--NLAS 191
Cdd:cd19072  127 VEEGKIRYIGVSNFSLEELEEAQSYLKKGPIVANQVeyNLFD 168
AKR_GlAR-like cd19128
Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), ...
 84-187 1.07e-03

Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), also called aldehyde reductase, is the prototype of this family. It catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.


Pssm-ID: 381354 [Multi-domain]  Cd Length: 277  Bit Score: 39.81  E-value: 1.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688566999  84 EREELKVSVKLFLTEWDCSSIRSAVDMACLSLGVSQLDSVIIAPP---------SLPEGESQTL---THLQPLWQELESL 151
Cdd:cd19128   57 KREDLFITSKLWPTMHQPENVKEQLLITLQDLQLEYLDLFLIHWPlafdmdtdgDPRDDNQIQSlskKPLEDTWRAMEQC 136

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 688566999 152 VQSQKIAAIGTSDLDKTLLEQLYNWAqQIKPSSNQV 187
Cdd:cd19128  137 VDEKLTKNIGVSNYSTKLLTDLLNYC-KIKPFMNQI 171
AKR_AKR1E1-2 cd19110
AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1, ...
 85-187 1.15e-03

AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1,5-anhydro-D-fructose reductase (EC 1.1.1.263) from Mus musculus (liver, AKR1E1) and Homo sapiens (AKR1E2). 1,5-anhydro-D-fructose reductase), also called AF reductase, or aldo-keto reductase family 1 member C-like protein 2 (AKR1CL2), catalyzes the NADPH-dependent reduction of 1,5-anhydro-D-fructose (AF) to 1,5-anhydro-D-glucitol. AKR1E2 is a testis aldo-keto reductase (tAKR), which is also known as testis-specific protein (TSP), or LoopADR.


Pssm-ID: 381336 [Multi-domain]  Cd Length: 301  Bit Score: 39.56  E-value: 1.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688566999  85 REELKVSVKLFLTEWDCSSIRSAVDMACLSLGVSQLDSVII--------APPSLPEGESQTL----THLQPLWQELESLV 152
Cdd:cd19110   61 REDLFIVSKLWCTCHKKSLVKTACTRSLKALKLNYLDLYLIhwpmgfkpGEPDLPLDRSGMVipsdTDFLDTWEAMEDLV 140

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 688566999 153 QSQKIAAIGTSDLDKTLLEQLYNWAQ-QIKPSSNQV 187
Cdd:cd19110  141 IEGLVKNIGVSNFNHEQLERLLNKPGlRVKPVTNQI 176
AKR_AKR5A1_2 cd19156
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from ...
 85-208 1.24e-03

AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from Leishmania major and Trypanosoma brucei are founding members of aldo-keto reductase family 5 member A1 (AKR5A1) and A2 (AKR5A2), respectively. PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.


Pssm-ID: 381382 [Multi-domain]  Cd Length: 266  Bit Score: 39.42  E-value: 1.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688566999  85 REELKVSVKLFLTEWDCSSIRSAVDMACLSLGVSQLDSVIIAPPslpeGESQTLTHlqplWQELESLVQSQKIAAIGTSD 164
Cdd:cd19156   63 REEVFVTTKLWNSDQGYESTLAAFEESLEKLGLDYVDLYLIHWP----VKGKFKDT----WKAFEKLYKEKKVRAIGVSN 134

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 688566999 165 LDKTLLEQLYNWAqQIKPSSNQVNLASCCVMPPdLTAFAKEFDI 208
Cdd:cd19156  135 FHEHHLEELLKSC-KVAPMVNQIELHPLLTQEP-LRKFCKEKNI 176
AKR_AKR1G1_CeAKR cd19154
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding ...
 85-208 2.66e-03

Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381380 [Multi-domain]  Cd Length: 303  Bit Score: 38.55  E-value: 2.66e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688566999  85 REELKVSVKLFLTEWDCSSIRSAVDMACLSLGVSQLDSVII-APPSLPEGESQTLTH-----------LQPLWQELESLV 152
Cdd:cd19154   69 REDLFITTKLWTHEHAPEDVEEALRESLKKLQLEYVDLYLIhAPAAFKDDEGESGTMengmsihdavdVEDVWRGMEKVY 148

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 688566999 153 QSQKIAAIGTSDLDKTLLEQLYNwAQQIKPSSNQVNLAscCVMP-PDLTAFAKEFDI 208
Cdd:cd19154  149 DEGLTKAIGVSNFNNDQIQRILD-NARVKPHNNQVECH--LYFPqKELVEFCKKHNI 202
AKR_AKR3A1-2 cd19117
AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are ...
 85-214 4.71e-03

AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are founding members of aldo-keto reductase family 3 member A1 (AKR3A1) and A2 (AKR3A2), respectively. Gcy1p, also called galactose-inducible crystallin-like protein 1, is a glycerol dehydrogenase involved in glycerol catabolism under microaerobic conditions. It has mRNA binding activity. Ypr1p acts as a 2-methylbutyraldehyde reductase that displays high specific activity towards 2-methylbutyraldehyde, as well as other aldehydes such as hexanal.


Pssm-ID: 381343 [Multi-domain]  Cd Length: 284  Bit Score: 37.86  E-value: 4.71e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688566999  85 REELKVSVKLFLTEWdcSSIRSAVDMACLSLGVSQLDSVIIAPPS---------LPEGESQTLTHLQ-----PLWQELES 150
Cdd:cd19117   67 REEIFITTKLWCTWH--RRVEEALDQSLKKLGLDYVDLYLMHWPVpldpdgndfLFKKDDGTKDHEPdwdfiKTWELMQK 144

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 688566999 151 LVQSQKIAAIGTSDLDKTLLEQLY-NWAQQIKPSSNQVNLASccVMP-PDLTAFAKEFDIQLLTHS 214
Cdd:cd19117  145 LPATGKVKAIGVSNFSIKNLEKLLaSPSAKIVPAVNQIELHP--LLPqPKLVDFCKSKGIHATAYS 208
AKR_AKR3G1 cd19123
AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a ...
 85-214 5.44e-03

AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a founding member of aldo-keto reductase family 3 member G1 (AKR3G1). It is an aldo/keto reductase that catalyzes the NADPH-dependent reduction of aldehyde- and ketone-groups of different classes of carbonyl compounds to the corresponding alcohols.


Pssm-ID: 381349 [Multi-domain]  Cd Length: 297  Bit Score: 37.78  E-value: 5.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688566999  85 REELKVSVKLFLTEWDCSSIRSAVDMACLSLGVSQLDSVIIAPP-------SLPEGESQTLTHLQ-PL---WQELESLVQ 153
Cdd:cd19123   69 REDLWITSKLWNNSHAPEDVLPALEKTLADLQLDYLDLYLMHWPvalkkgvGFPESGEDLLSLSPiPLedtWRAMEELVD 148

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 688566999 154 SQKIAAIGTSDLDKTLLEQLYNWAqQIKPSSNQVNLaSCCVMPPDLTAFAKEFDIQLLTHS 214
Cdd:cd19123  149 KGLCRHIGVSNFSVKKLEDLLATA-RIKPAVNQVEL-HPYLQQPELLAFCRDNGIHLTAYS 207
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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