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Conserved domains on  [gi|688569085|ref|XP_009302514|]
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radial spoke head 14 homolog isoform X2 [Danio rerio]

Protein Classification

HEAT repeat domain-containing protein( domain architecture ID 1001770)

HEAT repeat domain-containing protein similar to the N-terminal region of various adaptins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HEAT COG1413
HEAT repeat [General function prediction only];
186-329 2.55e-06

HEAT repeat [General function prediction only];


:

Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 46.16  E-value: 2.55e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688569085 186 ESDVIQVLRDQLSHSSPIIRKEAASALMAISVPTVgkikvceenlLPILVKLLSDDDQEVVANAAGTIMNTAvitkgkse 265
Cdd:COG1413   14 DPAAVPALIAALADEDPDVRAAAARALGRLGDPRA----------VPALLEALKDPDPEVRAAAAEALGRIG-------- 75

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 688569085 266 alEADALAPLLQLVLSENTAVCANALRAltvLAEVPRARAhlrqhVPLLKTRLTDPNYLIQEAA 329
Cdd:COG1413   76 --DPEAVPALIAALKDEDPEVRRAAAEA---LGRLGDPAA-----VPALLEALKDPDWEVRRAA 129
SRP1 super family cl34886
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
27-255 7.35e-04

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5064:

Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 41.41  E-value: 7.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688569085  27 ALPKLLVELQDDDLFTRQKALTALCDLLHDPErAYEAIFSEC--LEILKVLLQD---EDSLIRVKTtevlYVLASHSMGR 101
Cdd:COG5064  158 AVPLFIQLLSSTEDDVREQAVWALGNIAGDSE-GCRDYVLQCgaLEPLLGLLLSsaiHISMLRNAT----WTLSNLCRGK 232

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688569085 102 DAFLNFDIVGP----LANLLD--DPEIACrkNVHRALNRIAEFPLGAV-FMVNKGLVPRLVPKISIEEENIRALVLSTLS 174
Cdd:COG5064  233 NPPPDWSNISQalpiLAKLIYsrDPEVLV--DACWAISYLSDGPNEKIqAVLDVGIPGRLVELLSHESAKIQTPALRSVG 310

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688569085 175 CCLSVNALPA---LESDVIQVLRDQLSHSSPIIRKEAASALMAISVPTVGKIK-VCEENLLPILVKLLSDDDQEVVANAA 250
Cdd:COG5064  311 NIVTGSDDQTqviINCGALKAFRSLLSSPKENIRKEACWTISNITAGNTEQIQaVIDANLIPPLIHLLSSAEYKIKKEAC 390


                 ....*
gi 688569085 251 GTIMN 255
Cdd:COG5064  391 WAISN 395
 
Name Accession Description Interval E-value
HEAT COG1413
HEAT repeat [General function prediction only];
186-329 2.55e-06

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 46.16  E-value: 2.55e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688569085 186 ESDVIQVLRDQLSHSSPIIRKEAASALMAISVPTVgkikvceenlLPILVKLLSDDDQEVVANAAGTIMNTAvitkgkse 265
Cdd:COG1413   14 DPAAVPALIAALADEDPDVRAAAARALGRLGDPRA----------VPALLEALKDPDPEVRAAAAEALGRIG-------- 75

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 688569085 266 alEADALAPLLQLVLSENTAVCANALRAltvLAEVPRARAhlrqhVPLLKTRLTDPNYLIQEAA 329
Cdd:COG1413   76 --DPEAVPALIAALKDEDPEVRRAAAEA---LGRLGDPAA-----VPALLEALKDPDWEVRRAA 129
Adaptin_N pfam01602
Adaptin N terminal region; This family consists of the N terminal region of various alpha, ...
 62-335 4.15e-06

Adaptin N terminal region; This family consists of the N terminal region of various alpha, beta and gamma subunits of the AP-1, AP-2 and AP-3 adaptor protein complexes. The adaptor protein (AP) complexes are involved in the formation of clathrin-coated pits and vesicles. The N-terminal region of the various adaptor proteins (APs) is constant by comparison to the C-terminal which is variable within members of the AP-2 family; and it has been proposed that this constant region interacts with another uniform component of the coated vesicles.


Pssm-ID: 396262 [Multi-domain]  Cd Length: 523  Bit Score: 48.39  E-value: 4.15e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688569085   62 EAIFSECLEILKVLLQDedslIRVKTTEVLYVLASHSMGRDA-FLNFDIVgplaNLLDDPEIACRKNVHRALNRIAEFPL 140
Cdd:pfam01602   3 KRIQQELARILNSFRDD----PRKKKNAVKKLLYLIMLGEDIsFLFFEVV----KLVASKDFTLKRLGYLYLMLLAEESP 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688569085  141 GAVFMVNKGLVPRLvpkiSIEEENIRALVLSTLSCCLSVNALPALESDVIQVLRDqlshSSPIIRKEAASALMAIsvptv 220
Cdd:pfam01602  75 DLAILVTNSIQKDL----QSPNQLIRGLALRTLSCIRVPELARDLAPDIKKLLVD----RSPYVRKKAALAILKL----- 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688569085  221 gkIKVCEE---NLLPILVKLLSDDDQEVVANAAGTImntAVITKGKSEALEadaLAPLLQLVLSENTAVCAN-----ALR 292
Cdd:pfam01602 142 --YRKSPDlvrDFVPELKELLSDKDPGVQSAAVALL---YEICKNDRLYLK---LLPLLFRRLCNLLGVLNPwlqvkILR 213

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 688569085  293 ALTVLAEV-PRARAHLRQHV-PLLKTRLtdpNYLIQEAASTTIEV 335
Cdd:pfam01602 214 LLTRLAPLdPLLPKELLEDLlNLLQNSN---NAVLYETANTIVHL 255
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
27-255 7.35e-04

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 41.41  E-value: 7.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688569085  27 ALPKLLVELQDDDLFTRQKALTALCDLLHDPErAYEAIFSEC--LEILKVLLQD---EDSLIRVKTtevlYVLASHSMGR 101
Cdd:COG5064  158 AVPLFIQLLSSTEDDVREQAVWALGNIAGDSE-GCRDYVLQCgaLEPLLGLLLSsaiHISMLRNAT----WTLSNLCRGK 232

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688569085 102 DAFLNFDIVGP----LANLLD--DPEIACrkNVHRALNRIAEFPLGAV-FMVNKGLVPRLVPKISIEEENIRALVLSTLS 174
Cdd:COG5064  233 NPPPDWSNISQalpiLAKLIYsrDPEVLV--DACWAISYLSDGPNEKIqAVLDVGIPGRLVELLSHESAKIQTPALRSVG 310

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688569085 175 CCLSVNALPA---LESDVIQVLRDQLSHSSPIIRKEAASALMAISVPTVGKIK-VCEENLLPILVKLLSDDDQEVVANAA 250
Cdd:COG5064  311 NIVTGSDDQTqviINCGALKAFRSLLSSPKENIRKEACWTISNITAGNTEQIQaVIDANLIPPLIHLLSSAEYKIKKEAC 390


                 ....*
gi 688569085 251 GTIMN 255
Cdd:COG5064  391 WAISN 395
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 233-314 1.93e-03

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 40.09  E-value: 1.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688569085  233 ILVKLLSDDDQEVVANAAGTI--MNTAVITKGkSEALEADALAPLLQLVLSENT----AVCANALRALTvlAEVPRARAH 306
Cdd:PLN03200  193 ILVKLLSSGNSDAQANAASLLarLMMAFESSI-SKVLDAGAVKQLLKLLGQGNEvsvrAEAAGALEALS--SQSKEAKQA 269

                          90
                  ....*....|
gi 688569085  307 LRQH--VPLL 314
Cdd:PLN03200  270 IADAggIPAL 279
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 222-253 3.16e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 35.10  E-value: 3.16e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 688569085   222 KIKVCEENLLPILVKLLSDDDQEVVANAAGTI 253
Cdd:smart00185   5 KQAVVDAGGLPALVELLKSEDEEVVKEAAWAL 36
 
Name Accession Description Interval E-value
HEAT COG1413
HEAT repeat [General function prediction only];
186-329 2.55e-06

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 46.16  E-value: 2.55e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688569085 186 ESDVIQVLRDQLSHSSPIIRKEAASALMAISVPTVgkikvceenlLPILVKLLSDDDQEVVANAAGTIMNTAvitkgkse 265
Cdd:COG1413   14 DPAAVPALIAALADEDPDVRAAAARALGRLGDPRA----------VPALLEALKDPDPEVRAAAAEALGRIG-------- 75

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 688569085 266 alEADALAPLLQLVLSENTAVCANALRAltvLAEVPRARAhlrqhVPLLKTRLTDPNYLIQEAA 329
Cdd:COG1413   76 --DPEAVPALIAALKDEDPEVRRAAAEA---LGRLGDPAA-----VPALLEALKDPDWEVRRAA 129
Adaptin_N pfam01602
Adaptin N terminal region; This family consists of the N terminal region of various alpha, ...
 62-335 4.15e-06

Adaptin N terminal region; This family consists of the N terminal region of various alpha, beta and gamma subunits of the AP-1, AP-2 and AP-3 adaptor protein complexes. The adaptor protein (AP) complexes are involved in the formation of clathrin-coated pits and vesicles. The N-terminal region of the various adaptor proteins (APs) is constant by comparison to the C-terminal which is variable within members of the AP-2 family; and it has been proposed that this constant region interacts with another uniform component of the coated vesicles.


Pssm-ID: 396262 [Multi-domain]  Cd Length: 523  Bit Score: 48.39  E-value: 4.15e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688569085   62 EAIFSECLEILKVLLQDedslIRVKTTEVLYVLASHSMGRDA-FLNFDIVgplaNLLDDPEIACRKNVHRALNRIAEFPL 140
Cdd:pfam01602   3 KRIQQELARILNSFRDD----PRKKKNAVKKLLYLIMLGEDIsFLFFEVV----KLVASKDFTLKRLGYLYLMLLAEESP 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688569085  141 GAVFMVNKGLVPRLvpkiSIEEENIRALVLSTLSCCLSVNALPALESDVIQVLRDqlshSSPIIRKEAASALMAIsvptv 220
Cdd:pfam01602  75 DLAILVTNSIQKDL----QSPNQLIRGLALRTLSCIRVPELARDLAPDIKKLLVD----RSPYVRKKAALAILKL----- 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688569085  221 gkIKVCEE---NLLPILVKLLSDDDQEVVANAAGTImntAVITKGKSEALEadaLAPLLQLVLSENTAVCAN-----ALR 292
Cdd:pfam01602 142 --YRKSPDlvrDFVPELKELLSDKDPGVQSAAVALL---YEICKNDRLYLK---LLPLLFRRLCNLLGVLNPwlqvkILR 213

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 688569085  293 ALTVLAEV-PRARAHLRQHV-PLLKTRLtdpNYLIQEAASTTIEV 335
Cdd:pfam01602 214 LLTRLAPLdPLLPKELLEDLlNLLQNSN---NAVLYETANTIVHL 255
HEAT COG1413
HEAT repeat [General function prediction only];
204-329 7.51e-05

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 41.92  E-value: 7.51e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688569085 204 IRKEAASALMAISVPTVgkikvceenlLPILVKLLSDDDQEVVANAAGTImntavitkgkSEALEADALAPLLQLVLSEN 283
Cdd:COG1413    1 VRRAAARALGRLGDPAA----------VPALIAALADEDPDVRAAAARAL----------GRLGDPRAVPALLEALKDPD 60

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 688569085 284 TAVCANALRALtvlaevprARAHLRQHVPLLKTRLTDPNYLIQEAA 329
Cdd:COG1413   61 PEVRAAAAEAL--------GRIGDPEAVPALIAALKDEDPEVRRAA 98
HEAT COG1413
HEAT repeat [General function prediction only];
151-294 7.58e-05

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 41.92  E-value: 7.58e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688569085 151 VPRLVPKISIEEENIRALVLSTLSCCLSVNALPALesdviqvlRDQLSHSSPIIRKEAASALMAISVPTVgkikvceenl 230
Cdd:COG1413   18 VPALIAALADEDPDVRAAAARALGRLGDPRAVPAL--------LEALKDPDPEVRAAAAEALGRIGDPEA---------- 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 688569085 231 LPILVKLLSDDDQEVVANAAGTImntavitkgkSEALEADALAPLLQLVLSENTAVCANALRAL 294
Cdd:COG1413   80 VPALIAALKDEDPEVRRAAAEAL----------GRLGDPAAVPALLEALKDPDWEVRRAAARAL 133
COG5096 COG5096
Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular ...
 159-256 2.57e-04

Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 227427 [Multi-domain]  Cd Length: 757  Bit Score: 42.79  E-value: 2.57e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688569085 159 SIEEEN--IRALVLSTLSCcLSVnalPALESDVIQVLRDQLSHSSPIIRKEAASALmaISVPTVGKIKVCEENLLPILVK 236
Cdd:COG5096  100 DLQDPNeeIRGFALRTLSL-LRV---KELLGNIIDPIKKLLTDPHAYVRKTAALAV--AKLYRLDKDLYHELGLIDILKE 173

                         90       100
                 ....*....|....*....|
gi 688569085 237 LLSDDDQEVVANAAGTIMNT 256
Cdd:COG5096  174 LVADSDPIVIANALASLAEI 193
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
27-255 7.35e-04

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 41.41  E-value: 7.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688569085  27 ALPKLLVELQDDDLFTRQKALTALCDLLHDPErAYEAIFSEC--LEILKVLLQD---EDSLIRVKTtevlYVLASHSMGR 101
Cdd:COG5064  158 AVPLFIQLLSSTEDDVREQAVWALGNIAGDSE-GCRDYVLQCgaLEPLLGLLLSsaiHISMLRNAT----WTLSNLCRGK 232

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688569085 102 DAFLNFDIVGP----LANLLD--DPEIACrkNVHRALNRIAEFPLGAV-FMVNKGLVPRLVPKISIEEENIRALVLSTLS 174
Cdd:COG5064  233 NPPPDWSNISQalpiLAKLIYsrDPEVLV--DACWAISYLSDGPNEKIqAVLDVGIPGRLVELLSHESAKIQTPALRSVG 310

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688569085 175 CCLSVNALPA---LESDVIQVLRDQLSHSSPIIRKEAASALMAISVPTVGKIK-VCEENLLPILVKLLSDDDQEVVANAA 250
Cdd:COG5064  311 NIVTGSDDQTqviINCGALKAFRSLLSSPKENIRKEACWTISNITAGNTEQIQaVIDANLIPPLIHLLSSAEYKIKKEAC 390


                 ....*
gi 688569085 251 GTIMN 255
Cdd:COG5064  391 WAISN 395
HEAT COG1413
HEAT repeat [General function prediction only];
108-253 7.35e-04

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 39.23  E-value: 7.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688569085 108 DIVGPLANLLDDPEIACRKNVHRALNRIAefplgavfmvNKGLVPRLVPKISIEEENIRALVLSTLSCCLSVNALPALes 187
Cdd:COG1413   16 AAVPALIAALADEDPDVRAAAARALGRLG----------DPRAVPALLEALKDPDPEVRAAAAEALGRIGDPEAVPAL-- 83

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 688569085 188 dviqvlRDQLSHSSPIIRKEAASALmaisvptvGKIKvcEENLLPILVKLLSDDDQEVVANAAGTI 253
Cdd:COG1413   84 ------IAALKDEDPEVRRAAAEAL--------GRLG--DPAAVPALLEALKDPDWEVRRAAARAL 133
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 186-250 1.61e-03

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 36.93  E-value: 1.61e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 688569085  186 ESDVIQVLRDQLSHSSPIIRKEAASALMAISVPTVgkikvceenlLPILVKLLSDDDQEVVANAA 250
Cdd:pfam13646  29 DPEAVPALLELLKDEDPAVRRAAAEALGKIGDPEA----------LPALLELLRDDDDDVVRAAA 83
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 233-314 1.93e-03

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 40.09  E-value: 1.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688569085  233 ILVKLLSDDDQEVVANAAGTI--MNTAVITKGkSEALEADALAPLLQLVLSENT----AVCANALRALTvlAEVPRARAH 306
Cdd:PLN03200  193 ILVKLLSSGNSDAQANAASLLarLMMAFESSI-SKVLDAGAVKQLLKLLGQGNEvsvrAEAAGALEALS--SQSKEAKQA 269

                          90
                  ....*....|
gi 688569085  307 LRQH--VPLL 314
Cdd:PLN03200  270 IADAggIPAL 279
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
198-314 2.87e-03

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 39.49  E-value: 2.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688569085 198 SHSSPIIRKEAASALMAISVPTVGKIK-VCEENLLPILVKLLSDDDQEVVANAAGTIMNTAvitkGKSEA-----LEADA 271
Cdd:COG5064  125 EIQRDMLQFEAAWALTNIASGTTQQTKvVVDAGAVPLFIQLLSSTEDDVREQAVWALGNIA----GDSEGcrdyvLQCGA 200

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 688569085 272 LAPLLQLVLSenTAVCANALRALT-VLAEVPRAR------AHLRQHVPLL 314
Cdd:COG5064  201 LEPLLGLLLS--SAIHISMLRNATwTLSNLCRGKnpppdwSNISQALPIL 248
Cnd1 pfam12717
non-SMC mitotic condensation complex subunit 1; The three non-SMC (structural maintenance of ...
 165-249 3.00e-03

non-SMC mitotic condensation complex subunit 1; The three non-SMC (structural maintenance of chromosomes) subunits of the mitotic condensation complex are Cnd1-3. The whole complex is essential for viability and the condensing of chromosomes in mitosis.


Pssm-ID: 463677 [Multi-domain]  Cd Length: 162  Bit Score: 37.83  E-value: 3.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688569085  165 IRALVLSTLsCCLSVNALpaLESDVIQvLRDQLSHSSPIIRKeaaSALMAIS-VPTVGKIKVceENLLPILVKLLSDDDQ 243
Cdd:pfam12717   2 IRALAIRTM-GCIRFPNL--VEYLTEP-LYRRLKDEDPYVRK---TAAMCVAkLILPDMVKV--KGFISELAKLLEDPNP 72


                  ....*.
gi 688569085  244 EVVANA 249
Cdd:pfam12717  73 MVVANA 78
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 222-253 3.10e-03

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 35.12  E-value: 3.10e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 688569085  222 KIKVCEENLLPILVKLLSDDDQEVVANAAGTI 253
Cdd:pfam00514   5 KQAVIEAGAVPPLVRLLSSPDEEVQEEAAWAL 36
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 202-253 3.15e-03

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 35.42  E-value: 3.15e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 688569085  202 PIIRKEAASALMAISVPTVGKIKVCEENLLPILVKLLSDDDQEVVANAAGTI 253
Cdd:pfam13513   1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWAL 52
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 222-253 3.16e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 35.10  E-value: 3.16e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 688569085   222 KIKVCEENLLPILVKLLSDDDQEVVANAAGTI 253
Cdd:smart00185   5 KQAVVDAGGLPALVELLKSEDEEVVKEAAWAL 36
COG5096 COG5096
Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular ...
 183-297 5.28e-03

Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 227427 [Multi-domain]  Cd Length: 757  Bit Score: 38.56  E-value: 5.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688569085 183 PALESDVIQVLRDQLSHSSPIIRKeaasalMAISvpTVGKIKVCE--ENLLPILVKLLSDDDQEVVANAAGTIMNtaVIT 260
Cdd:COG5096   87 PELALLAVNTIQKDLQDPNEEIRG------FALR--TLSLLRVKEllGNIIDPIKKLLTDPHAYVRKTAALAVAK--LYR 156

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 688569085 261 KGKSEALEADALAPLLQLVLSENTAVCANALRALTVL 297
Cdd:COG5096  157 LDKDLYHELGLIDILKELVADSDPIVIANALASLAEI 193
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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