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Conserved domains on  [gi|755518592|ref|XP_011239878|]
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alpha-N-acetylneuraminide alpha-2,8-sialyltransferase isoform X3 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GT29 super family cl45931
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 72-198 6.98e-86

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


The actual alignment was detected with superfamily member cd23989:

Pssm-ID: 480271  Cd Length: 272  Bit Score: 255.53  E-value: 6.98e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518592  72 TSASLFRRQMEDCCDPAHLFAMTKMNSPMGKSLWYDGELLYSFTIDNSTYSLFPQATPFQLPLKKCAVVGNGGILKMSGC 151
Cdd:cd23989    1 TAVEAFRKLLEDCCDPKRLFAVTKHNSPLGKNLWFDGEFLHSHTVDNETYSLFPQDTPLQLPLKKCSVVGNGGILKNSGC 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 755518592 152 GRQIDEANFVMRCNLPPLSSEYTRDVGSKTQLVTANPSIIRQRQSNK 198
Cdd:cd23989   81 GQQIDRADFVMRCNLPPLSREYTDDVGTKTQLVTANPSIIDKRFQNL 127
 
Name Accession Description Interval E-value
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 72-198 6.98e-86

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 255.53  E-value: 6.98e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518592  72 TSASLFRRQMEDCCDPAHLFAMTKMNSPMGKSLWYDGELLYSFTIDNSTYSLFPQATPFQLPLKKCAVVGNGGILKMSGC 151
Cdd:cd23989    1 TAVEAFRKLLEDCCDPKRLFAVTKHNSPLGKNLWFDGEFLHSHTVDNETYSLFPQDTPLQLPLKKCSVVGNGGILKNSGC 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 755518592 152 GRQIDEANFVMRCNLPPLSSEYTRDVGSKTQLVTANPSIIRQRQSNK 198
Cdd:cd23989   81 GQQIDRADFVMRCNLPPLSREYTDDVGTKTQLVTANPSIIDKRFQNL 127
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 93-197 7.13e-41

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 139.66  E-value: 7.13e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518592   93 MTKMNSPMGKSLWYdGELLYSFTIDNSTYSLFPQATPFQ-LPLKKCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPLsS 171
Cdd:pfam00777   2 LTKENFPLGEWIRY-SEWWLPFTVTEELLELLPKVSPFDnKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPT-K 79

                          90       100
                  ....*....|....*....|....*..
gi 755518592  172 EYTRDVGSKTQLVTANP-SIIRQRQSN 197
Cdd:pfam00777  80 GYEKDVGSKTTLRTMNPeSAIDSKYGN 106
 
Name Accession Description Interval E-value
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 72-198 6.98e-86

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 255.53  E-value: 6.98e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518592  72 TSASLFRRQMEDCCDPAHLFAMTKMNSPMGKSLWYDGELLYSFTIDNSTYSLFPQATPFQLPLKKCAVVGNGGILKMSGC 151
Cdd:cd23989    1 TAVEAFRKLLEDCCDPKRLFAVTKHNSPLGKNLWFDGEFLHSHTVDNETYSLFPQDTPLQLPLKKCSVVGNGGILKNSGC 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 755518592 152 GRQIDEANFVMRCNLPPLSSEYTRDVGSKTQLVTANPSIIRQRQSNK 198
Cdd:cd23989   81 GQQIDRADFVMRCNLPPLSREYTDDVGTKTQLVTANPSIIDKRFQNL 127
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 72-197 5.82e-64

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 199.41  E-value: 5.82e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518592  72 TSASLFRRQMEDCCDPAHLFAMTKMNSPMGKSLWYDGELLYSFTIDNSTYSLFPQATPFQ-LPLKKCAVVGNGGILKMSG 150
Cdd:cd23971    1 TEHQQFRSELRSCCNASHELVVTQENTPLGSKIHYEGERKKTITVNEKLFSMLPKESPFSnKPLKTCAVVGNGGILKNSS 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 755518592 151 CGRQIDEANFVMRCNLPPLSseYTRDVGSKTQLVTANPSIIRQRQSN 197
Cdd:cd23971   81 CGREIDSADFVIRCNLPPLN--DSKDVGSKTNLVTANPSILREKFHN 125
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 72-197 7.60e-45

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 150.49  E-value: 7.60e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518592  72 TSASLFRRQMEDCCDPAHLFAmTKMNSPMGKSLWYDGELLYSFTIDNSTYSLFPQATPF-QLPLKKCAVVGNGGILKMSG 150
Cdd:cd23963    1 TALDKFRKELERLLNTRKLFL-TQKNTPLGDVLYYSYFKKKTFKITKSLYELLPKTSPFsHKRYKTCAVVGNSGILLGSG 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 755518592 151 CGRQIDEANFVMRCNLPPLsSEYTRDVGSKTQLVTANPSIIRQRQSN 197
Cdd:cd23963   80 CGKEIDSHDFVIRCNLPPI-KGFEKDVGRKTNLTTLNPSILKRRYNS 125
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 77-197 9.29e-45

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 150.29  E-value: 9.29e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518592  77 FRRQMEDCCDPAHLFAMTKMNSPMGKSLWYDGELLYSFTIDNSTYSLFPQATPFQ-LPLKKCAVVGNGGILKMSGCGRQI 155
Cdd:cd23991    6 FRSELSSCCNAVQNFIVSQNNTPLGTNLTYEVEPKKKILITENIFRMFPKSQPFRgYPYKQCAVVGNGGILKNSSCGAEI 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 755518592 156 DEANFVMRCNLPPLSSEYTRDVGSKTQLVTANPSIIRQRQSN 197
Cdd:cd23991   86 DQADFVFRCNLPPTGGNISKDVGSKTNLVTANPSIISIKYAK 127
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 72-194 3.56e-42

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 143.82  E-value: 3.56e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518592  72 TSASLFRRQMEDCCDPAHLFAMTKMNSPMGKSLWYDGELLYSFTIDNSTYSLFPQATPF-QLPLKKCAVVGNGGILKMSG 150
Cdd:cd23990    1 TEANAFKSSLSRCCNAPSFLFTTQKNTPLGTKLKYEVDTSGIYHINSEIFKMFPKDMPYsRSQFKKCAVVGNGGILKNSK 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 755518592 151 CGRQIDEANFVMRCNLPPLSSEYTRDVGSKTQLVTANPSIIRQR 194
Cdd:cd23990   81 CGREIDSADFVFRCNLPPISEKYVRDVGVKTDVVTINPSIITER 124
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 93-197 7.13e-41

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 139.66  E-value: 7.13e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518592   93 MTKMNSPMGKSLWYdGELLYSFTIDNSTYSLFPQATPFQ-LPLKKCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPLsS 171
Cdd:pfam00777   2 LTKENFPLGEWIRY-SEWWLPFTVTEELLELLPKVSPFDnKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPT-K 79

                          90       100
                  ....*....|....*....|....*..
gi 755518592  172 EYTRDVGSKTQLVTANP-SIIRQRQSN 197
Cdd:pfam00777  80 GYEKDVGSKTTLRTMNPeSAIDSKYGN 106
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 70-197 1.75e-35

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 126.74  E-value: 1.75e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518592  70 NQTSASLFRRQMEDCCDPAHLFAMTKMNSPMGKSLWYD-GELLYSFTIDNSTYSLFPQATPFQ-LPLKKCAVVGNGGILK 147
Cdd:cd23970    2 NKTALLHQRKEIRQYFDVIKNISLTKKDVRIGQLMHFDySSHKYVFSISPNLRSLLPEVSPFQnKHYNTCAVVGNSGILT 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 755518592 148 MSGCGRQIDEANFVMRCNLPPLSSeYTRDVGSKTQLVTANPSIIRQRQSN 197
Cdd:cd23970   82 NSQCGNEIDKSDFVFRCNFAPTEG-FEKDVGRKTNLTTFNPSILEKYYNN 130
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 78-191 2.22e-30

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 113.28  E-value: 2.22e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518592  78 RRQMEDCCDPAHLFAMTKMNSPMGKSLWYDGELLYSFTIDNSTYSLFPQATPFQLPL-KKCAVVGNGGILKMSGCGRQID 156
Cdd:cd23969    7 RKWILKFFDPEKDISVLKSQVKPGDRMHYEIDRHKTVNITQDLYQLLPEVSPLKGKHfRTCAVVGNSGILLNSGCGQEID 86

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 755518592 157 EANFVMRCNLPPLsSEYTRDVGSKTQLVTANPSII 191
Cdd:cd23969   87 SHDFVIRCNLAPV-EGYEKDVGTKSNLTTMNPSVI 120
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 113-193 5.06e-23

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 93.85  E-value: 5.06e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518592 113 SFTIDNSTYSLFPQATPFQ-LPLKKCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPLsSEYTRDVGSKTQLVTANPSII 191
Cdd:cd23987   42 TMNISQNLYELLPRTSPLKnKHFKTCAIVGNSGILLNSGCGREIDSHDFVIRCNLAPV-EEYAKDVGTKTDLVTMNPSVV 120


                 ..
gi 755518592 192 RQ 193
Cdd:cd23987  121 QR 122
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 113-193 2.07e-22

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 91.94  E-value: 2.07e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518592 113 SFTIDNSTYSLFPQATPFQ-LPLKKCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPLsSEYTRDVGSKTQLVTANPSII 191
Cdd:cd23988   42 TLNISQNLHSLLPEVSPMKnRRFKTCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPV-VEFAADVGTKSDFITMNPSVV 120


                 ..
gi 755518592 192 RQ 193
Cdd:cd23988  121 QR 122
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 137-197 1.52e-14

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 69.31  E-value: 1.52e-14
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755518592 137 CAVVGNGGILKMSGCGRQIDEANFVMRCNLPPlSSEYTRDVGSKTQLVTANPSIIRQRQSN 197
Cdd:cd19952    1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAP-TKGFEKDVGSKTTFRVLNSKWAGFYLRG 60
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 136-181 1.34e-11

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 62.28  E-value: 1.34e-11
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 755518592 136 KCAVVGNGGILKMSGCGRQIDEANFVMRCNLpPLSSEYTRDVGSKT 181
Cdd:cd23964   84 RCAVVGNGGILNGSGKGKEIDAHDYVFRVNH-ALTKGFEKDVGTKT 128
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 136-181 5.37e-10

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 57.68  E-value: 5.37e-10
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 755518592 136 KCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPLSSeYTRDVGSKT 181
Cdd:cd23966   79 RCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKG-FEKDVGSKT 123
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 133-185 8.26e-10

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 57.02  E-value: 8.26e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518592 133 PLKKCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPLSSeYTRDVGSKT-------QLVT 185
Cdd:cd23985   44 PLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPTAG-FQQDVGTKTtirlinsQLVT 102
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 135-200 2.83e-09

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 55.66  E-value: 2.83e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755518592 135 KKCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPlSSEYTRDVGSKTQLVTANPSIIRQRQSNKAM 200
Cdd:cd23980   82 RRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAP-TEGFEADVGSKTTHHFVYPESFRELAQNVSM 146
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 133-181 3.80e-09

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 54.61  E-value: 3.80e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 755518592 133 PLKKCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPLSSeYTRDVGSKT 181
Cdd:cd23967    1 SCRRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKG-YEKDVGSKT 48
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 117-181 2.04e-08

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 53.29  E-value: 2.04e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755518592 117 DNSTYSLFPqatPFQLPLK--KCAVVGNGGILKMSGCGRQIDEANFVMRCNlPPLSSEYTRDVGSKT 181
Cdd:cd23972   66 DSANAKLFF---PRDTPGKciRCAVVGNGGILNGSRQGRAIDAHDYVFRLN-GAVIKGFEEDVGTKT 128
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 133-183 3.36e-08

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 52.05  E-value: 3.36e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 755518592 133 PLKKCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPLSSeYTRDVGSKTQL 183
Cdd:cd23983    1 TCRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQG-YSQDVGNKTTI 50
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 133-191 3.79e-08

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 51.67  E-value: 3.79e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 755518592 133 PLKKCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPLSSeYTRDVGSKTQLVTANP-SII 191
Cdd:cd23984    1 SCKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIG-YENDVGKRTTFRLCYPeSIF 59
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 136-185 5.12e-08

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 52.06  E-value: 5.12e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 755518592 136 KCAVVGNGGILKMSGCGRQIDEANFVMRCNlPPLSSEYTRDVGSKTQLVT 185
Cdd:cd23974   86 RCAVVGNGGILNGSRMGAEIDGHDYVFRVN-GAITKGFEKDVGRRTSFYT 134
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 135-197 5.30e-08

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 51.46  E-value: 5.30e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755518592 135 KKCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPLSSeYTRDVGSKTQLVTANPSIIRQRQSN 197
Cdd:cd23981    3 RRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKG-FEKDVGSKTTLRITYPEGAIQKPEQ 64
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 133-183 5.57e-08

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 51.20  E-value: 5.57e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 755518592 133 PLKKCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPLsSEYTRDVGSKTQL 183
Cdd:cd23982    1 RCRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPV-RGFEKDVGSKTTI 50
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 135-181 1.03e-07

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 51.03  E-value: 1.03e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 755518592 135 KKCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPlSSEYTRDVGSKT 181
Cdd:cd23979   81 RRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAP-TVGFEADVGSRT 126
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 121-183 1.08e-07

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 51.12  E-value: 1.08e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755518592 121 YSLFPQATPFQLPLKKCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPLsSEYTRDVGSKTQL 183
Cdd:cd23968   32 YPFPESSLENTKRYNTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPT-KGFEKDVGSKTTL 93
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 136-181 4.99e-07

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 49.36  E-value: 4.99e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 755518592 136 KCAVVGNGGILKMSGCGRQIDEANFVMRCNlPPLSSEYTRDVGSKT 181
Cdd:cd23973   85 RCAVVGNGGILNGSKMGQEIDSHDYVFRVN-GAVIKGYEEDVGTRT 129
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 129-204 1.37e-06

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 47.56  E-value: 1.37e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755518592 129 PFQLPLKKCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPlSSEYTRDVGSKTQL-VTANPSIIR-QRQSNKAMGSTH 204
Cdd:cd23976   10 PLKMHCKSCALVTSSGHLTGSNRGNEIDETECVIRMNDAP-TRGYGKDVGNKTSLrVIAHSSIQRiLRNRNELLNVSQ 86
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 134-191 1.96e-06

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 47.14  E-value: 1.96e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 755518592 134 LKKCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPlSSEYTRDVGSKTQLVTANPSII 191
Cdd:cd23986   49 FRSCAVVTSAGAILNSSLGKEIDSHDAVLRFNSAP-TRGYEKDVGNKTTIRIINSQIL 105
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 135-194 2.07e-05

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 44.08  E-value: 2.07e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755518592 135 KKCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPlSSEYTRDVGSKTQLV----TANPSIIRQR 194
Cdd:cd23977    2 RRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAP-TAGYEADVGNRSSLRvvshTSVPLLLRNQ 64
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 135-197 2.50e-05

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 43.77  E-value: 2.50e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755518592 135 KKCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPLSSeYTRDVGSKTQL-VTANPSIIRQRQSN 197
Cdd:cd23965    2 DTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRG-YEKDVGRRTTIrVVSHSSLPRLLRNA 64
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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