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Conserved domains on  [gi|755532774|ref|XP_011241411|]
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PR domain zinc finger protein 1 isoform X4 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PR-SET_PRDM1 cd19187
PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins; PRDM1 ...
 45-173 1.65e-89

PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins; PRDM1 (also termed BLIMP-1, beta-interferon gene positive regulatory domain I-binding factor, PR domain-containing protein 1, positive regulatory domain I-binding factor 1, PRDI-BF1, or PRDI-binding factor 1) acts as a transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs.


:

Pssm-ID: 380964 [Multi-domain]  Cd Length: 128  Bit Score: 277.29  E-value: 1.65e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755532774  45 ASLPRNLLFKYAANNsKEVIGVVSKEYIPKGTRFGPLIGEVYTNDTVPKNANRKYFWRIYSREEFHHFIDGFNEEKSNWM 124
Cdd:cd19187    1 ASLPRNLTLKYSSVG-REVLGVWSSDYIPRGTRFGPLVGEIYTNDPVPKGANRKYFWRIYSNGEFYHYIDGFDPSKSNWM 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 755532774 125 RYVNPAHSAREQNLAACQNGMNIYFYTIKPIPANQELLVWYCRDFAERL 173
Cdd:cd19187   80 RYVNPAHSLQEQNLVACQIGMNIYFYTVKPIPPNQELLVWYCREFARRL 128
zf-H2C2_2 pfam13465
Zinc-finger double domain;
581-606 8.13e-06

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.13  E-value: 8.13e-06
                          10        20
                  ....*....|....*....|....*.
gi 755532774  581 HLQKHYLVHTGEKPHECQVCHKRFSS 606
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
609-634 8.45e-06

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 42.74  E-value: 8.45e-06
                          10        20
                  ....*....|....*....|....*.
gi 755532774  609 NLKTHLRLHSGEKPYQCKVCPAKFTQ 634
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
385-652 1.01e-05

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.92  E-value: 1.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755532774 385 ISSNGLSTMNNINGINNFSLFPRLY------PVYSNLLSGSSLP----HPMLNPASLPSSLPTDGARRLLP--PEHPKEV 452
Cdd:COG5048   86 HHNNPSDLNSKSLPLSNSKASSSSLsssssnSNDNNLLSSHSLPpssrDPQLPDLLSISNLRNNPLPGNNSssVNTPQSN 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755532774 453 LIPAPHSAFSLTGAAASMKDESSPPSGSPTAGTAATSEHVVQPK-------------ATSSVMAAPSTDGAMNLIKNKRN 519
Cdd:COG5048  166 SLHPPLPANSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYsipssssdqnlenSSSSLPLTTNSQLSPKSLLSQSP 245

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755532774 520 MTGYKTLPYPlkkqNGKIKYECNVCAKTFGQLSNLKVHLRVHSGER-PFKCQTCNKGFTQLAHLQKHY--LVHTGE--KP 594
Cdd:COG5048  246 SSLSSSDSSS----SASESPRSSLPTASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKP 321

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755532774 595 HEC--QVCHKRFSSTSNLKTHLRLHSGEKPYQCK--VCPAKFTQFVHLKLHKRLHTRERPHK 652
Cdd:COG5048  322 FSCpySLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNNEPPQSLQQYKDLKN 383
 
Name Accession Description Interval E-value
PR-SET_PRDM1 cd19187
PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins; PRDM1 ...
 45-173 1.65e-89

PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins; PRDM1 (also termed BLIMP-1, beta-interferon gene positive regulatory domain I-binding factor, PR domain-containing protein 1, positive regulatory domain I-binding factor 1, PRDI-BF1, or PRDI-binding factor 1) acts as a transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs.


Pssm-ID: 380964 [Multi-domain]  Cd Length: 128  Bit Score: 277.29  E-value: 1.65e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755532774  45 ASLPRNLLFKYAANNsKEVIGVVSKEYIPKGTRFGPLIGEVYTNDTVPKNANRKYFWRIYSREEFHHFIDGFNEEKSNWM 124
Cdd:cd19187    1 ASLPRNLTLKYSSVG-REVLGVWSSDYIPRGTRFGPLVGEIYTNDPVPKGANRKYFWRIYSNGEFYHYIDGFDPSKSNWM 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 755532774 125 RYVNPAHSAREQNLAACQNGMNIYFYTIKPIPANQELLVWYCRDFAERL 173
Cdd:cd19187   80 RYVNPAHSLQEQNLVACQIGMNIYFYTVKPIPPNQELLVWYCREFARRL 128
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 65-171 9.80e-24

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 97.02  E-value: 9.80e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755532774    65 GVVSKEYIPKGTRFGPLIGEVYTNDTVPK--------NANRKYFWRIYSreefHHFIDGFNeeKSNWMRYVNPAHSAREQ 136
Cdd:smart00317  14 GVRATEDIPKGEFIGEYVGEIITSEEAEErpkaydtdGAKAFYLFDIDS----DLCIDARR--KGNLARFINHSCEPNCE 87

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 755532774   137 NLAACQNGMN-IYFYTIKPIPANQELLVWYCRDFAE 171
Cdd:smart00317  88 LLFVEVNGDDrIVIFALRDIKPGEELTIDYGSDYAN 123
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 65-165 4.04e-14

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 69.09  E-value: 4.04e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755532774   65 GVVSKEYIPKGTRFGPLIGE-VYTNDTVPKNANRKYFWRIYSREEFHHF---------IDGFNEEKSNWMRYVNpaHSAR 134
Cdd:pfam00856   3 GLFATEDIPKGEFIGEYVEVlLITKEEADKRELLYYDKLELRLWGPYLFtldedseycIDARALYYGNWARFIN--HSCD 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 755532774  135 EQNLAACQ---NGMNIYFYTIKPIPANQELLVWY 165
Cdd:pfam00856  81 PNCEVRVVyvnGGPRIVIFALRDIKPGEELTIDY 114
zf-H2C2_2 pfam13465
Zinc-finger double domain;
581-606 8.13e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.13  E-value: 8.13e-06
                          10        20
                  ....*....|....*....|....*.
gi 755532774  581 HLQKHYLVHTGEKPHECQVCHKRFSS 606
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
609-634 8.45e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 42.74  E-value: 8.45e-06
                          10        20
                  ....*....|....*....|....*.
gi 755532774  609 NLKTHLRLHSGEKPYQCKVCPAKFTQ 634
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
385-652 1.01e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.92  E-value: 1.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755532774 385 ISSNGLSTMNNINGINNFSLFPRLY------PVYSNLLSGSSLP----HPMLNPASLPSSLPTDGARRLLP--PEHPKEV 452
Cdd:COG5048   86 HHNNPSDLNSKSLPLSNSKASSSSLsssssnSNDNNLLSSHSLPpssrDPQLPDLLSISNLRNNPLPGNNSssVNTPQSN 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755532774 453 LIPAPHSAFSLTGAAASMKDESSPPSGSPTAGTAATSEHVVQPK-------------ATSSVMAAPSTDGAMNLIKNKRN 519
Cdd:COG5048  166 SLHPPLPANSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYsipssssdqnlenSSSSLPLTTNSQLSPKSLLSQSP 245

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755532774 520 MTGYKTLPYPlkkqNGKIKYECNVCAKTFGQLSNLKVHLRVHSGER-PFKCQTCNKGFTQLAHLQKHY--LVHTGE--KP 594
Cdd:COG5048  246 SSLSSSDSSS----SASESPRSSLPTASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKP 321

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755532774 595 HEC--QVCHKRFSSTSNLKTHLRLHSGEKPYQCK--VCPAKFTQFVHLKLHKRLHTRERPHK 652
Cdd:COG5048  322 FSCpySLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNNEPPQSLQQYKDLKN 383
zf-H2C2_2 pfam13465
Zinc-finger double domain;
553-578 3.14e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 3.14e-05
                          10        20
                  ....*....|....*....|....*.
gi 755532774  553 NLKVHLRVHSGERPFKCQTCNKGFTQ 578
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 565-617 4.07e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.77  E-value: 4.07e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 755532774 565 RPFkCQTCNKGFTQLAHLQ-----KHYlvhtgekphECQVCHKRFSSTSNLKTH-LRLH 617
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIqhqkaKHF---------KCHICHKKLYTAGGLAVHcLQVH 49
ZnF_C2H2 smart00355
zinc finger;
595-617 9.57e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 34.36  E-value: 9.57e-03
                           10        20
                   ....*....|....*....|...
gi 755532774   595 HECQVCHKRFSSTSNLKTHLRLH 617
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23
 
Name Accession Description Interval E-value
PR-SET_PRDM1 cd19187
PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins; PRDM1 ...
 45-173 1.65e-89

PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins; PRDM1 (also termed BLIMP-1, beta-interferon gene positive regulatory domain I-binding factor, PR domain-containing protein 1, positive regulatory domain I-binding factor 1, PRDI-BF1, or PRDI-binding factor 1) acts as a transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs.


Pssm-ID: 380964 [Multi-domain]  Cd Length: 128  Bit Score: 277.29  E-value: 1.65e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755532774  45 ASLPRNLLFKYAANNsKEVIGVVSKEYIPKGTRFGPLIGEVYTNDTVPKNANRKYFWRIYSREEFHHFIDGFNEEKSNWM 124
Cdd:cd19187    1 ASLPRNLTLKYSSVG-REVLGVWSSDYIPRGTRFGPLVGEIYTNDPVPKGANRKYFWRIYSNGEFYHYIDGFDPSKSNWM 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 755532774 125 RYVNPAHSAREQNLAACQNGMNIYFYTIKPIPANQELLVWYCRDFAERL 173
Cdd:cd19187   80 RYVNPAHSLQEQNLVACQIGMNIYFYTVKPIPPNQELLVWYCREFARRL 128
PR-SET_PRDM7_9 cd19193
PR-SET domain found in PR domain zinc finger protein 7 (PRDM7) and 9 (PRDM9) and similar ...
 65-173 2.19e-32

PR-SET domain found in PR domain zinc finger protein 7 (PRDM7) and 9 (PRDM9) and similar proteins; PRDM7 (also termed PR domain-containing protein 7) is a primate-specific histone methyltransferase that is the result of a recent gene duplication of PRDM9. It selectively catalyzes the trimethylation of H3 lysine 4 (H3K4me3). PRDM9 (also termed PR domain-containing protein 9) is a histone methyltransferase that specifically trimethylates 'Lys-4' of histone H3 (H3K4me3) during meiotic prophase and is essential for proper meiotic progression. It also efficiently mono-, di-, and trimethylates H3K36. Aberrant PRDM9 expression is assciated with with genome instability in cancer.


Pssm-ID: 380970 [Multi-domain]  Cd Length: 129  Bit Score: 121.96  E-value: 2.19e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755532774  65 GVVSKEYIPKGTRFGPLIGEVYTNDTVPKNAnrkYFWRIYSREEFHHFIDGFNEEKSNWMRYVNPAHSAREQNLAACQNG 144
Cdd:cd19193   21 GVWAEAPIPKGMVFGPYEGEIVEDEEAADSG---YSWQIYKGGKLSHYIDAKDESKSNWMRYVNCARNEEEQNLVAFQYR 97

                         90       100
                 ....*....|....*....|....*....
gi 755532774 145 MNIYFYTIKPIPANQELLVWYCRDFAERL 173
Cdd:cd19193   98 GKIYYRTCKDIAPGTELLVWYGDEYAKEL 126
PR-SET_PRDM4 cd19189
PR-SET domain found in PR domain zinc finger protein 4 (PRDM4) and similar proteins; PRDM4 ...
 42-173 6.28e-30

PR-SET domain found in PR domain zinc finger protein 4 (PRDM4) and similar proteins; PRDM4 (also termed PR domain-containing protein 4, or PFM1) may function as a transcription factor involved in cell differentiation.


Pssm-ID: 380966  Cd Length: 133  Bit Score: 114.87  E-value: 6.28e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755532774  42 QAEASLPRNLLFKYAAnnSKEVIGVVSKEYIPKGTRFGPLIGEVYTNDTVP--KNANRKYFWRIYSREEFHHFIDGFNEE 119
Cdd:cd19189    1 RARLSLPRQLYLRQSE--TGAEVGVWTKETIPVRTCFGPLIGQQSHSAEVAdwTDKAAPHIWKIYHNDVLEFCIITTDEN 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 755532774 120 KSNWMRYVNPAHSAREQNLAACQNGMNIYFYTIKPIPANQELLVWYCRDFAERL 173
Cdd:cd19189   79 ECNWMMFVRKARTREEQNLVAYPHDGKIYFCTSRDIPPDQELLFYYSRDYARQL 132
PR-SET_PRDM10 cd19194
PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins; PRDM10 ...
 43-173 1.40e-29

PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins; PRDM10 (also termed PR domain-containing protein 10, or tristanin) may be involved in transcriptional regulation.


Pssm-ID: 380971  Cd Length: 128  Bit Score: 113.99  E-value: 1.40e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755532774  43 AEASLPRNL-LFKYAANnskeVIGVVSKEYIPKGTRFGPLIGEVYTNDTVPKNanrkYFWRIYSREEFHH--FIDGFNEE 119
Cdd:cd19194    2 ARASLPLILqIFRFGET----LGGVFAKRRIPKRTQFGPLEGPLVKKSELKDN----KIHPLELEEDDGEdlYFDLSDEN 73

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 755532774 120 KSNWMRYVNPAHSAREQNLAACQNGMNIYFYTIKPIPANQELLVWYCRDFAERL 173
Cdd:cd19194   74 KCNWMMFVRPAQNHLEQNLVAYQYGQEIYFTTIKNIEPKQELKVWYAASYAEFL 127
PR-SET_PRDM-like cd10534
PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family ...
 47-165 3.10e-28

PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family of proteins is defined based on the conserved N-terminal PR domain, which is closely related to the Su(var)3-9, enhancer of zeste, and trithorax (SET) domains of histone methyltransferases, and is specifically called PR-SET domain. The family consists of 17 members in primates. PRDMs play diverse roles in cell-cycle regulation, differentiation, and meiotic recombination. The family also contains zinc finger protein ZFPM1 and ZFPM2. ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380932  Cd Length: 83  Bit Score: 108.44  E-value: 3.10e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755532774  47 LPRNLLFKYAANnSKEVIGVVSKEYIPKGTRFGPLIGEVytndtvpknanrkyfwriysreefhhfidgfneeksNWMRY 126
Cdd:cd10534    1 LPAGLELVLSSI-PEGGLGVFARRTIPAGTRFGPLEGVV------------------------------------NWMRF 43

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 755532774 127 VNPAHSAREQNLAACQNGMNIYFYTIKPIPANQELLVWY 165
Cdd:cd10534   44 VRPARNEEEQNLVAYQHGGQIYFRTTRDIPPGEELLVWY 82
PR-SET_PRDM14 cd19198
PR-SET domain found in PR domain zinc finger protein 14 (PRDM14) and similar proteins; PRDM14 ...
 65-165 9.76e-27

PR-SET domain found in PR domain zinc finger protein 14 (PRDM14) and similar proteins; PRDM14 (also termed PR domain-containing protein 14) acts as a transcription factor that has both positive and negative roles on transcription. It acts on regulating epigenetic modifications in the cells, playing a key role in the regulation of cell pluripotency, epigenetic reprogramming, differentiation and development. Aberrant PRDM14 expression is associated with tumorigenesis, cell migration and cell chemotherapeutic drugs resistance.


Pssm-ID: 380975  Cd Length: 133  Bit Score: 105.94  E-value: 9.76e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755532774  65 GVVSKEYIPKGTRFGPLIGEVYTNDTVPKNANRKYFWRIYSREEFHHFIDGfNEEKSNWMRYVNPAHSAREQNLAACQNG 144
Cdd:cd19198   21 GVFCKKTIPKGTRFGPFRGRVVNTSEIKTYDDNSFMWEIFEDGKLSHFIDG-RGSTGNWMSYVNCARYAEEQNLIAIQCQ 99

                         90       100
                 ....*....|....*....|.
gi 755532774 145 MNIYFYTIKPIPANQELLVWY 165
Cdd:cd19198  100 GQIFYESCKEILQGQELLVWY 120
PR-SET_PRDM12 cd19196
PR-SET domain found in PR domain zinc finger protein 12 (PRDM12) and similar proteins; PRDM12 ...
 64-176 1.40e-26

PR-SET domain found in PR domain zinc finger protein 12 (PRDM12) and similar proteins; PRDM12 (also termed PR domain-containing protein 12) acts as a transcription factor that is involved in the positive regulation of histone H3-K9 dimethylation.


Pssm-ID: 380973 [Multi-domain]  Cd Length: 130  Bit Score: 105.52  E-value: 1.40e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755532774  64 IGVVSKEYIPKGTRFGPLIGEVYTNDTVPKNANRKYFWRIY-SREEFHHFIDGFNEEKSNWMRYVNPAHSAREQNLAACQ 142
Cdd:cd19196   17 LGVFSKTWIKEGTEMGPYTGRIVSPEDVDPCKNNNLMWEVFnEDGTVSHFIDASQENHRSWMTFVNCARNEQEQNLEVVQ 96

                         90       100       110
                 ....*....|....*....|....*....|....
gi 755532774 143 NGMNIYFYTIKPIPANQELLVWYCRDFAERLHYP 176
Cdd:cd19196   97 IGESIYYRAIKDIPPDQELLVWYGNSYNTFLGIP 130
PR-SET_PRDM6 cd19191
PR-SET domain found in PR domain zinc finger protein 6 (PRDM6) and similar proteins; PRDM6 ...
 65-165 3.56e-26

PR-SET domain found in PR domain zinc finger protein 6 (PRDM6) and similar proteins; PRDM6 (also termed PR domain-containing protein 6) is a putative histone-lysine N-methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. It may specifically methylate 'Lys-20' of histone H4 when associated with other proteins and in vitro.


Pssm-ID: 380968  Cd Length: 128  Bit Score: 104.10  E-value: 3.56e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755532774  65 GVVSKEYIPKGTRFGPLIGEVYTNDTVPKNA-NRKYFWRIYSRE-EFHHFIDGFNEEKSNWMRYVNPAHSAREQNLAACQ 142
Cdd:cd19191   18 GICAAQRIPQGTWIGPFEGVLVSPEKQIGAVrNTQHLWEIYDQEgTLQHFIDGGDPSKSSWMRYIRCARHCGEQNLTVVQ 97

                         90       100
                 ....*....|....*....|...
gi 755532774 143 NGMNIYFYTIKPIPANQELLVWY 165
Cdd:cd19191   98 YRGCIFYRACRDIPRGTELLVWY 120
PR-SET_PRDM2 cd19188
PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins; PRDM2 ...
 47-165 3.04e-24

PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins; PRDM2 (also termed GATA-3-binding protein G3B, lysine N-methyltransferase 8, MTB-or MTE-binding protein, PR domain-containing protein 2, retinoblastoma protein-interacting zinc finger protein, or zinc finger protein RIZ) is S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. It may function as a DNA-binding transcription factor.


Pssm-ID: 380965  Cd Length: 123  Bit Score: 98.28  E-value: 3.04e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755532774  47 LPRNLLFKYAANnSKEVIGVVSKEYIPKGTRFGPLIGEVYTNDTVPKNAnrkYFWRIYSREEFHHFIDGFNEEKSNWMRY 126
Cdd:cd19188    4 LPEELELKPSAV-DKTRIGVWAKKSIPKGRKFGPFVGEKKKRSQVKNNV---YMWEIYGPKRGWMCVDASDPTKGNWLRY 79

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 755532774 127 VNPAHSAREQNLAACQNGMNIYFYTIKPIPANQELLVWY 165
Cdd:cd19188   80 VNWARSGEEQNLFPLQINRAIYYKTLKPIAPGEELLCWY 118
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 65-171 9.80e-24

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 97.02  E-value: 9.80e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755532774    65 GVVSKEYIPKGTRFGPLIGEVYTNDTVPK--------NANRKYFWRIYSreefHHFIDGFNeeKSNWMRYVNPAHSAREQ 136
Cdd:smart00317  14 GVRATEDIPKGEFIGEYVGEIITSEEAEErpkaydtdGAKAFYLFDIDS----DLCIDARR--KGNLARFINHSCEPNCE 87

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 755532774   137 NLAACQNGMN-IYFYTIKPIPANQELLVWYCRDFAE 171
Cdd:smart00317  88 LLFVEVNGDDrIVIFALRDIKPGEELTIDYGSDYAN 123
PR-SET_PRDM11 cd19195
PR-SET domain found in PR domain zinc finger protein 11 (PRDM11) and similar proteins; PRDM11 ...
 70-174 7.14e-21

PR-SET domain found in PR domain zinc finger protein 11 (PRDM11) and similar proteins; PRDM11 (also termed PR domain-containing protein 11) may be involved in transcription regulation.


Pssm-ID: 380972  Cd Length: 127  Bit Score: 89.15  E-value: 7.14e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755532774  70 EYIPKGTRFGPLIGEVYTNDtvpkNANRKYFWRIYSREEFHHFIDGFNEEKSNWMRYVNPAHSAREQNLAACQNGMNIYF 149
Cdd:cd19195   26 EVIPKGHIFGPYEGQICTQD----KSSGFFSWLIVDKNNRYKSIDGSDETKANWMRYVVISREEREQNLLAFQHSEQIYF 101

                         90       100
                 ....*....|....*....|....*
gi 755532774 150 YTIKPIPANQELLVWYCRDFAERLH 174
Cdd:cd19195  102 RACRDIRPGEKLRVWYSEDYMKRLH 126
PR-SET_PRDM15 cd19199
PR-SET domain found in PR domain zinc finger protein 15 (PRDM15) and similar proteins; PRDM15 ...
 42-173 4.86e-20

PR-SET domain found in PR domain zinc finger protein 15 (PRDM15) and similar proteins; PRDM15 (also termed PR domain-containing protein 15, or zinc finger protein 298 (ZNF298)) may be involved in transcriptional regulation. It plays an essential role as a chromatin factor that modulates the transcription of upstream regulators of WNT and MAPK-ERK signaling to safeguard naive pluripotency.


Pssm-ID: 380976  Cd Length: 126  Bit Score: 86.70  E-value: 4.86e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755532774  42 QAEASLPRNLLFKYAANNSKeviGVVSKEYIPKGTRFGPLIG-EVYTNDTVPKnanrKYFwRIYSREEFHHFIDGFNEEK 120
Cdd:cd19199    2 RARSSLPDNLEIRQLEDGSE---GVFALVPLVKRTQFGPFEAkRVARLDGFAV----FPL-KVFEKDGSVVYLDTSNEDD 73

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 755532774 121 SNWMRYVNPAHSAREQNLAACQNGMNIYFYTIKPIPANQELLVWYCRDFAERL 173
Cdd:cd19199   74 CNWMMFVRPATDVEHQNLTAYQQGEDIYFTTSRDIQPGAELRVWYAAFYAKKM 126
PR-SET_ZFPM cd19201
PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also ...
 46-169 8.26e-17

PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380978  Cd Length: 122  Bit Score: 77.00  E-value: 8.26e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755532774  46 SLPRNLLFKYAANNSKEVIGVVSKEYIPKGTRFGPLIGEVytndtVPKNANRKYFWRIYSRE-EFHHFIDGFNEEKSNWM 124
Cdd:cd19201    2 SLPGELELRKPSQDAGRSGGVWAKQPLPEGTRFGPYPGKL-----VKEPLDPSYEWKVEAQGsKGGEGLLLLTEDSGTWL 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 755532774 125 RYVNPAHSAREQNLAACQNGMNIYFYTIKPIPANQELLVWYCRDF 169
Cdd:cd19201   77 KLVRSADDEDEANLILYFKGGQIWCEVTKDIPPGEELILVLREPL 121
PR-SET_PRDM5 cd19190
PR-SET domain found in PR domain zinc finger protein 5 (PRDM5) and similar proteins; PRDM5 ...
 53-165 1.02e-15

PR-SET domain found in PR domain zinc finger protein 5 (PRDM5) and similar proteins; PRDM5 (also termed PR domain-containing protein 5) is a sequence-specific DNA-binding transcription factor that represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1.


Pssm-ID: 380967  Cd Length: 127  Bit Score: 74.25  E-value: 1.02e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755532774  53 FKYAANNSKEVIGVVSKEYIPKGTRFGPLIGEVYTNDTVPKNANRKYFWRIY-SREEFHHFIDGFNEEKSNWMRYVNPAH 131
Cdd:cd19190    9 FSLKSSKVQDGMGLYTARRVKKGEKFGPFAGEKRMPNELDESMDPRLMWEVRgSKGEVLYILDASNPRHSNWLRFVHEAP 88

                         90       100       110
                 ....*....|....*....|....*....|....
gi 755532774 132 SAREQNLAACQNGMNIYFYTIKPIPANQELLVWY 165
Cdd:cd19190   89 SQEQKNLAAIQEGENIFYLAVDDIETDTELLIGY 122
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 65-165 4.04e-14

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 69.09  E-value: 4.04e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755532774   65 GVVSKEYIPKGTRFGPLIGE-VYTNDTVPKNANRKYFWRIYSREEFHHF---------IDGFNEEKSNWMRYVNpaHSAR 134
Cdd:pfam00856   3 GLFATEDIPKGEFIGEYVEVlLITKEEADKRELLYYDKLELRLWGPYLFtldedseycIDARALYYGNWARFIN--HSCD 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 755532774  135 EQNLAACQ---NGMNIYFYTIKPIPANQELLVWY 165
Cdd:pfam00856  81 PNCEVRVVyvnGGPRIVIFALRDIKPGEELTIDY 114
PR-SET_PRDM8 cd19192
PR-SET domain found in PR domain zinc finger protein 8 (PRDM8) and similar proteins; PRDM8 ...
 64-173 5.24e-14

PR-SET domain found in PR domain zinc finger protein 8 (PRDM8) and similar proteins; PRDM8 (also termed PR domain-containing protein 8) may function as histone methyltransferase, preferentially acting on 'Lys-9' of histone H3.


Pssm-ID: 380969  Cd Length: 131  Bit Score: 69.38  E-value: 5.24e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755532774  64 IGVVSKEYIPKGTRFGPLIGEVYTNDTVPKNANRKYFWRI-YSREEFHHFIDGFNEEKSNWMRYVNPAHSAREQNLAA-C 141
Cdd:cd19192   20 TSVVTTTDIPAGTIFGPCVLSFTLGYDIADIALKTTDKRVvPYIFRVDTGACNGSSEPSDWLRLVQPARDRHEQNLEAfR 99

                         90       100       110
                 ....*....|....*....|....*....|..
gi 755532774 142 QNGMNIYFYTIKPIPANQELLVWYCRDFAERL 173
Cdd:cd19192  100 KNEGQVYFRTLRRIRKGEELLVWYSDELAELL 131
PR-SET_PRDM16_PRDM3 cd19200
PR-SET domain found in PR domain zinc finger protein 16 (PRDM16), MDS1 and EVI1 complex locus ...
 64-163 1.06e-13

PR-SET domain found in PR domain zinc finger protein 16 (PRDM16), MDS1 and EVI1 complex locus protein and similar proteins; PRDM16 (also termed PR domain-containing protein 16, transcription factor MEL1, or MDS1/EVI1-like gene 1) functions as a transcriptional regulator. PRDM16 is preferentially expressed by hematopoietic and neuronal stem cells. It is closely related to paralog of PRDM3 (also termed MDS1 and EVI1 complex locus protein, ecotropic virus integration site 1 protein, EVI-1, myelodysplasia syndrome 1 protein, myelodysplasia syndrome-associated protein 1, or MECOM) which is a nuclear transcription factor essential for the proliferation/maintenance of hematopoietic stem cells (HSCs). PRDM3 and PRDM16 are both directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380977  Cd Length: 135  Bit Score: 68.55  E-value: 1.06e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755532774  64 IGVVSKEYIPKGTRFGPLIGevytndtVPKNA--NRKYFWRIYsrEEFHH---FIDGFNEEKSNWMRYVNPAHSAREQNL 138
Cdd:cd19200   26 LGVWTKVRIEVGEKFGPFVG-------VQRSSvkDPTYAWEIV--DEFGKvkfWIDASEPGTGNWMKYIRSAPSCEQQNL 96

                         90       100
                 ....*....|....*....|....*
gi 755532774 139 AACQNGMNIYFYTIKPIPANQELLV 163
Cdd:cd19200   97 MACQIDEQIYYKVVRDIQPGEELLL 121
PR-SET_PRDM13 cd19197
PR-SET domain found in PR domain zinc finger protein 13 (PRDM13) and similar proteins; PRDM13 ...
 72-165 4.81e-10

PR-SET domain found in PR domain zinc finger protein 13 (PRDM13) and similar proteins; PRDM13 (also termed PR domain-containing protein 13) may be involved in transcriptional regulation. It mediates the balance of inhibitory and excitatory neurons in somatosensory circuits.


Pssm-ID: 380974  Cd Length: 103  Bit Score: 57.14  E-value: 4.81e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755532774  72 IPKGTRFGPLIGEV----YTNDTvpKNANRKYFWRIYSREefhHFIDGFNEEKSNWMRYVNPAHSAREQNLAACQN--GM 145
Cdd:cd19197    1 IPAGLRLGPVPGIFklgkYLSDR--KEPGNKKKVRRVRGD---YLVDESGSPATEWIGLVRAARNNQEQNLEAIADlpGG 75

                         90       100
                 ....*....|....*....|
gi 755532774 146 NIYFYTIKPIPANQELLVWY 165
Cdd:cd19197   76 QIFYRALRDIQPGEELTVWY 95
PR-SET_PRDM17 cd10520
PR-SET domain found in PR domain zinc finger protein 17 (PRDM17) and similar proteins; PRDM17 ...
 46-164 1.13e-09

PR-SET domain found in PR domain zinc finger protein 17 (PRDM17) and similar proteins; PRDM17 (also termed zinc finger protein 408 (ZNF408)) may be involved in transcriptional regulation.


Pssm-ID: 380918  Cd Length: 121  Bit Score: 56.66  E-value: 1.13e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755532774  46 SLPRNLlfkyAANNS---KEVIGV--VSKEyIPKGTRFGPLIGEvytndTVPKNANRKYFWRIysrEEFHHFIDGF-NEE 119
Cdd:cd10520    4 SLPPGL----ALGPSlaqEERLGVwcVGDA-LQKGTFLGPLEEE-----LESHDLTEGGSPRQ---EESGQSGDVLaCEQ 70

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 755532774 120 KSNWMRYVNPAHSAREQNLAACQNGMNIYFYTIKPIPANQELLVW 164
Cdd:cd10520   71 SSKWMRFACRARSEEESNVAVVRLSGRLHLRVCKDIEPGSELLLW 115
PR-SET_PRDM16 cd19213
PR-SET domain found in PR domain zinc finger protein 16 (PRDM16) and similar proteins; PRDM16, ...
 64-164 1.32e-09

PR-SET domain found in PR domain zinc finger protein 16 (PRDM16) and similar proteins; PRDM16, also termed PR domain-containing protein 16, or transcription factor MEL1, or MDS1/EVI1-like gene 1, functions as a transcriptional regulator. PRDM16 is preferentially expressed by hematopoietic and neuronal stem cells and is closely related to paralog of PRDM3, both of which are directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380990  Cd Length: 162  Bit Score: 57.58  E-value: 1.32e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755532774  64 IGVVSKEYIPKGTRFGPLIG-------------EVYTND--TVPKNANRKYFWRIYSREEFhhFIDGFNEEKSNWMRYVN 128
Cdd:cd19213   36 LGVWAKRKIEAGERFGPYTGvqrstlkdtnfgwEQILNDveVSSQEGCITKIVDDLGNEKF--CVDAGQAGAGSWLKYIR 113

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 755532774 129 PAHSAREQNLAACQNGMNIYFYTIKPIPANQELLVW 164
Cdd:cd19213  114 VACSCDEQNLTACQINEQIYYKVIKDIEPGEELLVY 149
SET_LegAS4-like cd10522
SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and ...
 65-165 1.92e-08

SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and similar proteins; LegAS4 is a type IV secretion system effector of Legionella pneumophila. It contains a SET domain that is involved in the modification of Lys4 of histone H3 (H3K4) in the nucleolus of the host cell, thereby enhancing heterochromatic rDNA transcription. It also contains an ankyrin repeat domain of unknown function at its C-terminal region.


Pssm-ID: 380920 [Multi-domain]  Cd Length: 122  Bit Score: 53.11  E-value: 1.92e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755532774  65 GVVSKEYIPKGTRFGPLIGEVYTNDTVPKNANRKYFWR-IYSREEFHHFIDGFneEKSNWMRYVNpaHSAREqNLAA--- 140
Cdd:cd10522   16 GLFAAETIAKGEFVGEYTGEVLDRWEEDRDSVYHYDPLyPFDLNGDILVIDAG--KKGNLTRFIN--HSDQP-NLELivr 90

                         90       100
                 ....*....|....*....|....*.
gi 755532774 141 CQNGMN-IYFYTIKPIPANQELLVWY 165
Cdd:cd10522   91 TLKGEQhIGFVAIRDIKPGEELFISY 116
PR-SET_PRDM3 cd19214
PR-SET domain found in MDS1 and EVI1 complex locus protein and similar proteins; PRDM3 (also ...
 64-164 4.25e-07

PR-SET domain found in MDS1 and EVI1 complex locus protein and similar proteins; PRDM3 (also termed MDS1 and EVI1 complex locus protein, ecotropic virus integration site 1 protein, EVI-1, myelodysplasia syndrome 1 protein, myelodysplasia syndrome-associated protein 1, or MECOM) is a nuclear transcription factor, which is essential for the proliferation/maintenance of hematopoietic stem cells (HSCs). It is closely related to paralog PRDM16, both o fwhich are directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380991  Cd Length: 158  Bit Score: 50.32  E-value: 4.25e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755532774  64 IGVVSKEYIPKGTRFGPLIGEVYTNDTVPKnanrkYFWRIYsrEEFHHF---IDGFNEEKSNWMRYVNPAHSAREQNLAA 140
Cdd:cd19214   46 LGIWTKRKIEVGEKFGPYVGEQRSNLKDPS-----YGWEVL--DEFGNVkfcIDASQPDVGSWLKYIRFAGCYDQHNLVA 118

                         90       100
                 ....*....|....*....|....
gi 755532774 141 CQNGMNIYFYTIKPIPANQELLVW 164
Cdd:cd19214  119 CQINDQIFYRAVADIDPGEELLLF 142
zf-H2C2_2 pfam13465
Zinc-finger double domain;
581-606 8.13e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.13  E-value: 8.13e-06
                          10        20
                  ....*....|....*....|....*.
gi 755532774  581 HLQKHYLVHTGEKPHECQVCHKRFSS 606
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
609-634 8.45e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 42.74  E-value: 8.45e-06
                          10        20
                  ....*....|....*....|....*.
gi 755532774  609 NLKTHLRLHSGEKPYQCKVCPAKFTQ 634
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
385-652 1.01e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.92  E-value: 1.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755532774 385 ISSNGLSTMNNINGINNFSLFPRLY------PVYSNLLSGSSLP----HPMLNPASLPSSLPTDGARRLLP--PEHPKEV 452
Cdd:COG5048   86 HHNNPSDLNSKSLPLSNSKASSSSLsssssnSNDNNLLSSHSLPpssrDPQLPDLLSISNLRNNPLPGNNSssVNTPQSN 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755532774 453 LIPAPHSAFSLTGAAASMKDESSPPSGSPTAGTAATSEHVVQPK-------------ATSSVMAAPSTDGAMNLIKNKRN 519
Cdd:COG5048  166 SLHPPLPANSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYsipssssdqnlenSSSSLPLTTNSQLSPKSLLSQSP 245

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755532774 520 MTGYKTLPYPlkkqNGKIKYECNVCAKTFGQLSNLKVHLRVHSGER-PFKCQTCNKGFTQLAHLQKHY--LVHTGE--KP 594
Cdd:COG5048  246 SSLSSSDSSS----SASESPRSSLPTASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKP 321

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755532774 595 HEC--QVCHKRFSSTSNLKTHLRLHSGEKPYQCK--VCPAKFTQFVHLKLHKRLHTRERPHK 652
Cdd:COG5048  322 FSCpySLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNNEPPQSLQQYKDLKN 383
zf-H2C2_2 pfam13465
Zinc-finger double domain;
553-578 3.14e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 3.14e-05
                          10        20
                  ....*....|....*....|....*.
gi 755532774  553 NLKVHLRVHSGERPFKCQTCNKGFTQ 578
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
637-662 8.29e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 8.29e-05
                          10        20
                  ....*....|....*....|....*.
gi 755532774  637 HLKLHKRLHTRERPHKCAQCHKSYIH 662
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 595-617 2.16e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.82  E-value: 2.16e-04
                          10        20
                  ....*....|....*....|...
gi 755532774  595 HECQVCHKRFSSTSNLKTHLRLH 617
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 539-561 8.88e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.28  E-value: 8.88e-04
                          10        20
                  ....*....|....*....|...
gi 755532774  539 YECNVCAKTFGQLSNLKVHLRVH 561
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 567-589 1.01e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.89  E-value: 1.01e-03
                          10        20
                  ....*....|....*....|...
gi 755532774  567 FKCQTCNKGFTQLAHLQKHYLVH 589
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 480-642 1.13e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 1.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755532774 480 SPTAGTAATSEHVVQPKaTSSVMAAPSTDGAMNLIKNKRNMTGYKTLPYPLKKQNGKIKYECNVCAKTFGqlSNLKVhlr 559
Cdd:COG5189  271 SPSQGSAELFEESSLGF-DYEFIHKSVGNKEIRGGISTGEMIDVRKLPCTNSSSNGKLAHGGERNIDTPS--RMLKV--- 344

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755532774 560 vhSGERPFKCQT--CNKGFTQLAHLQKHYLvhtgeKPHECQVCHKRFSSTSnlktHLRLHSGEKPYQCKVCPAKFTQFVH 637
Cdd:COG5189  345 --KDGKPYKCPVegCNKKYKNQNGLKYHML-----HGHQNQKLHENPSPEK----MNIFSAKDKPYRCEVCDKRYKNLNG 413


                 ....*
gi 755532774 638 LKLHK 642
Cdd:COG5189  414 LKYHR 418
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
565-622 2.13e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.22  E-value: 2.13e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 755532774 565 RPFKCQTCNKGFTQLAHLQKHYLVHTGEKPHECQV--CHKRFSSTSNLKTHLRLHSGEKP 622
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPS 91
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 565-617 4.07e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.77  E-value: 4.07e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 755532774 565 RPFkCQTCNKGFTQLAHLQ-----KHYlvhtgekphECQVCHKRFSSTSNLKTH-LRLH 617
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIqhqkaKHF---------KCHICHKKLYTAGGLAVHcLQVH 49
zf-C2H2_6 pfam13912
C2H2-type zinc finger;
595-620 5.56e-03

C2H2-type zinc finger;


Pssm-ID: 433576  Cd Length: 27  Bit Score: 34.91  E-value: 5.56e-03
                          10        20
                  ....*....|....*....|....*.
gi 755532774  595 HECQVCHKRFSSTSNLKTHLRLHSGE 620
Cdd:pfam13912   2 HECSECGKSFPSYQALGGHKKSHRKE 27
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 587-671 9.20e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.32  E-value: 9.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755532774 587 LVHTGEKPHECQV--CHKRFSSTSNLKTHlRLHSGekpyqckvCPAKFTQFVHLKLHKRLHTRERPHKCAQCHKSYIHLC 664
Cdd:COG5189  342 LKVKDGKPYKCPVegCNKKYKNQNGLKYH-MLHGH--------QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLN 412


                 ....*..
gi 755532774 665 SLKVHLK 671
Cdd:COG5189  413 GLKYHRK 419
ZnF_C2H2 smart00355
zinc finger;
595-617 9.57e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 34.36  E-value: 9.57e-03
                           10        20
                   ....*....|....*....|...
gi 755532774   595 HECQVCHKRFSSTSNLKTHLRLH 617
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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