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Conserved domains on  [gi|755542417|ref|XP_011242357|]
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WD repeat-containing protein 25 isoform X1 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 230-534 1.34e-38

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 142.86  E-value: 1.34e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542417 230 LFHLRGHRGPVNSIQWCPVfckSHMLLSASMDKTFKVWNaVDSGHCLQTYSVHSEAVRAARWSPCGRRILSGGFDFALHL 309
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSPD---GKLLATGSGDGTIKVWD-LETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542417 310 TDLETG--TQVFSGQSDfRVTTLKFHPKDHnVFLCGGFSSEIKAWDMRTGKVVKGYKATIQQTLDILFLQEGSeFLSSTd 387
Cdd:cd00200   78 WDLETGecVRTLTGHTS-YVSSVAFSPDGR-ILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGT-FVASS- 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542417 388 astrdSADRTIIAWDFRTAAKISNQIFHERYtCPSLALHPREPVFLAQTNGNylalFSSVWPYRMSR-RRRYEGHkvEGY 466
Cdd:cd00200  154 -----SQDGTIKLWDLRTGKCVATLTGHTGE-VNSVAFSPDGEKLLSSSSDG----TIKLWDLSTGKcLGTLRGH--ENG 221

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755542417 467 AVGCECSPCGDLLVTGSADGRVLMFSFRTASRACTLQGHTQACLGTTYHPvLPSVLGTCSWGGDIKIW 534
Cdd:cd00200  222 VNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSP-DGKRLASGSADGTIRIW 288
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 230-534 1.34e-38

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 142.86  E-value: 1.34e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542417 230 LFHLRGHRGPVNSIQWCPVfckSHMLLSASMDKTFKVWNaVDSGHCLQTYSVHSEAVRAARWSPCGRRILSGGFDFALHL 309
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSPD---GKLLATGSGDGTIKVWD-LETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542417 310 TDLETG--TQVFSGQSDfRVTTLKFHPKDHnVFLCGGFSSEIKAWDMRTGKVVKGYKATIQQTLDILFLQEGSeFLSSTd 387
Cdd:cd00200   78 WDLETGecVRTLTGHTS-YVSSVAFSPDGR-ILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGT-FVASS- 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542417 388 astrdSADRTIIAWDFRTAAKISNQIFHERYtCPSLALHPREPVFLAQTNGNylalFSSVWPYRMSR-RRRYEGHkvEGY 466
Cdd:cd00200  154 -----SQDGTIKLWDLRTGKCVATLTGHTGE-VNSVAFSPDGEKLLSSSSDG----TIKLWDLSTGKcLGTLRGH--ENG 221

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755542417 467 AVGCECSPCGDLLVTGSADGRVLMFSFRTASRACTLQGHTQACLGTTYHPvLPSVLGTCSWGGDIKIW 534
Cdd:cd00200  222 VNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSP-DGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
228-534 1.02e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 135.04  E-value: 1.02e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542417 228 KVLFHLRGHRGPVNSIQWCPvfcKSHMLLSASMDKTFKVWNaVDSGHCLQTYSVHSEAVRAARWSPCGRRILSGGFDFAL 307
Cdd:COG2319  111 LLLRTLTGHTGAVRSVAFSP---DGKTLASGSADGTVRLWD-LATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTV 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542417 308 HLTDLETGT--QVFSGQSDfRVTTLKFHPkDHNVFLCGGFSSEIKAWDMRTGKVVKGYKATIQQTLDILFLQEGSEFLSS 385
Cdd:COG2319  187 RLWDLATGKllRTLTGHTG-AVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASG 264

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542417 386 tdastrdSADRTIIAWDFRTAAKISNQIFHERYTCpSLALHPrepvflaqtNGNYLALFSS-----VWPYRMSRRRR-YE 459
Cdd:COG2319  265 -------SADGTVRLWDLATGELLRTLTGHSGGVN-SVAFSP---------DGKLLASGSDdgtvrLWDLATGKLLRtLT 327

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755542417 460 GHKVEGYAVgcECSPCGDLLVTGSADGRVLMFSFRTASRACTLQGHTQACLGTTYHPVlPSVLGTCSWGGDIKIW 534
Cdd:COG2319  328 GHTGAVRSV--AFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPD-GRTLASGSADGTVRLW 399
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 226-268 8.53e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 8.53e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 755542417   226 PKKVLFHLRGHRGPVNSIQWCPvfcKSHMLLSASMDKTFKVWN 268
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP---DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
227-268 1.81e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 1.81e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 755542417  227 KKVLFHLRGHRGPVNSIQWCPvfcKSHMLLSASMDKTFKVWN 268
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSP---DGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 216-335 3.01e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 43.40  E-value: 3.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542417 216 LNSQYRETTVPKkvlfhLRGHRGPVNSIQWCPvfCKSHMLLSASMDKTFKVW---------NAVDSGHCLqtYSVHSEAV 286
Cdd:PTZ00420  58 LENQMRKPPVIK-----LKGHTSSILDLQFNP--CFSEILASGSEDLTIRVWeiphndesvKEIKDPQCI--LKGHKKKI 128

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 755542417 287 RAARWSPCGRRIL-SGGFDFALHLTDLETGTQVFSGQSDFRVTTLKFHPK 335
Cdd:PTZ00420 129 SIIDWNPMNYYIMcSSGFDSFVNIWDIENEKRAFQINMPKKLSSLKWNIK 178
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 230-534 1.34e-38

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 142.86  E-value: 1.34e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542417 230 LFHLRGHRGPVNSIQWCPVfckSHMLLSASMDKTFKVWNaVDSGHCLQTYSVHSEAVRAARWSPCGRRILSGGFDFALHL 309
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSPD---GKLLATGSGDGTIKVWD-LETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542417 310 TDLETG--TQVFSGQSDfRVTTLKFHPKDHnVFLCGGFSSEIKAWDMRTGKVVKGYKATIQQTLDILFLQEGSeFLSSTd 387
Cdd:cd00200   78 WDLETGecVRTLTGHTS-YVSSVAFSPDGR-ILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGT-FVASS- 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542417 388 astrdSADRTIIAWDFRTAAKISNQIFHERYtCPSLALHPREPVFLAQTNGNylalFSSVWPYRMSR-RRRYEGHkvEGY 466
Cdd:cd00200  154 -----SQDGTIKLWDLRTGKCVATLTGHTGE-VNSVAFSPDGEKLLSSSSDG----TIKLWDLSTGKcLGTLRGH--ENG 221

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755542417 467 AVGCECSPCGDLLVTGSADGRVLMFSFRTASRACTLQGHTQACLGTTYHPvLPSVLGTCSWGGDIKIW 534
Cdd:cd00200  222 VNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSP-DGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
228-534 1.02e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 135.04  E-value: 1.02e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542417 228 KVLFHLRGHRGPVNSIQWCPvfcKSHMLLSASMDKTFKVWNaVDSGHCLQTYSVHSEAVRAARWSPCGRRILSGGFDFAL 307
Cdd:COG2319  111 LLLRTLTGHTGAVRSVAFSP---DGKTLASGSADGTVRLWD-LATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTV 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542417 308 HLTDLETGT--QVFSGQSDfRVTTLKFHPkDHNVFLCGGFSSEIKAWDMRTGKVVKGYKATIQQTLDILFLQEGSEFLSS 385
Cdd:COG2319  187 RLWDLATGKllRTLTGHTG-AVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASG 264

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542417 386 tdastrdSADRTIIAWDFRTAAKISNQIFHERYTCpSLALHPrepvflaqtNGNYLALFSS-----VWPYRMSRRRR-YE 459
Cdd:COG2319  265 -------SADGTVRLWDLATGELLRTLTGHSGGVN-SVAFSP---------DGKLLASGSDdgtvrLWDLATGKLLRtLT 327

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755542417 460 GHKVEGYAVgcECSPCGDLLVTGSADGRVLMFSFRTASRACTLQGHTQACLGTTYHPVlPSVLGTCSWGGDIKIW 534
Cdd:COG2319  328 GHTGAVRSV--AFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPD-GRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 229-492 1.52e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 120.52  E-value: 1.52e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542417 229 VLFHLRGHRGPVNSIQWCpvfCKSHMLLSASMDKTFKVWNaVDSGHCLQTYSVHSEAVRAARWSPCGRRILSGGFDFALH 308
Cdd:cd00200   43 LLRTLKGHTGPVRDVAAS---ADGTYLASGSSDKTIRLWD-LETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIK 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542417 309 LTDLETGT--QVFSGQSDFrVTTLKFHPkDHNVFLCGGFSSEIKAWDMRTGKVVKGYKATIQQTLDILFLQEGSEFLSSt 386
Cdd:cd00200  119 VWDVETGKclTTLRGHTDW-VNSVAFSP-DGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSS- 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542417 387 dastrdSADRTIIAWDFRTAAKISNQIFHERYtCPSLALHPrepvflaqtnGNYLALFSS------VWPYRM-SRRRRYE 459
Cdd:cd00200  196 ------SSDGTIKLWDLSTGKCLGTLRGHENG-VNSVAFSP----------DGYLLASGSedgtirVWDLRTgECVQTLS 258

                        250       260       270
                 ....*....|....*....|....*....|...
gi 755542417 460 GHKVEGYAVGCecSPCGDLLVTGSADGRVLMFS 492
Cdd:cd00200  259 GHTNSVTSLAW--SPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
233-535 8.17e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 121.17  E-value: 8.17e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542417 233 LRGHRGPVNSIQWCPVfckSHMLLSASMDKTFKVWNaVDSGHCLQTYSVHSEAVRAARWSPCGRRILSGGFDFALHLTDL 312
Cdd:COG2319   74 LLGHTAAVLSVAFSPD---GRLLASASADGTVRLWD-LATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542417 313 ETGT--QVFSGQSDfRVTTLKFHPkDHNVFLCGGFSSEIKAWDMRTGKVVKGYKATIQQTLDILFLQEGSEFLSStdast 390
Cdd:COG2319  150 ATGKllRTLTGHSG-AVTSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASG----- 222

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542417 391 rdSADRTIIAWDFRTAAKISNQIFHERYTCpSLALHPrepvflaqtNGNYLALFSS-----VW-PYRMSRRRRYEGHKVE 464
Cdd:COG2319  223 --SADGTVRLWDLATGKLLRTLTGHSGSVR-SVAFSP---------DGRLLASGSAdgtvrLWdLATGELLRTLTGHSGG 290

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755542417 465 GYAVgcECSPCGDLLVTGSADGRVLMFSFRTASRACTLQGHTQACLGTTYHPVlPSVLGTCSWGGDIKIWH 535
Cdd:COG2319  291 VNSV--AFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD-GKTLASGSDDGTVRLWD 358
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 228-427 6.39e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 104.72  E-value: 6.39e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542417 228 KVLFHLRGHRGPVNSIQWCPvfcKSHMLLSASMDKTFKVWNaVDSGHCLQTYSVHSEAVRAARWSPCGRRILSGGFDFAL 307
Cdd:cd00200   84 ECVRTLTGHTSYVSSVAFSP---DGRILSSSSRDKTIKVWD-VETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTI 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542417 308 HLTDLETGT--QVFSGQSDFrVTTLKFHPKDHNVFLCGGfSSEIKAWDMRTGKVVKGYKATIQQTLDILFLQEGSEFLSS 385
Cdd:cd00200  160 KLWDLRTGKcvATLTGHTGE-VNSVAFSPDGEKLLSSSS-DGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASG 237

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 755542417 386 tdastrdSADRTIIAWDFRTaAKISNQIFHERYTCPSLALHP 427
Cdd:cd00200  238 -------SEDGTIRVWDLRT-GECVQTLSGHTNSVTSLAWSP 271
WD40 COG2319
WD40 repeat [General function prediction only];
228-405 3.93e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.61  E-value: 3.93e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542417 228 KVLFHLRGHRGPVNSIQWCPvfcKSHMLLSASMDKTFKVWNaVDSGHCLQTYSVHSEAVRAARWSPCGRRILSGGFDFAL 307
Cdd:COG2319  195 KLLRTLTGHTGAVRSVAFSP---DGKLLASGSADGTVRLWD-LATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTV 270

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542417 308 HLTDLETGTQV--FSGQSDfRVTTLKFHPkDHNVFLCGGFSSEIKAWDMRTGKVVKGYKATIQQTLDILFLQEGSEFLSS 385
Cdd:COG2319  271 RLWDLATGELLrtLTGHSG-GVNSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASG 348

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 755542417 386 TD----------------------------ASTRD-------SADRTIIAWDFRT 405
Cdd:COG2319  349 SDdgtvrlwdlatgellrtltghtgavtsvAFSPDgrtlasgSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 275-534 1.23e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 95.09  E-value: 1.23e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542417 275 CLQTYSVHSEAVRAARWSPCGRRILSGGFDFALHLTDLETGTQV--FSGQSDFrVTTLKFHPkDHNVFLCGGFSSEIKAW 352
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLrtLKGHTGP-VRDVAASA-DGTYLASGSSDKTIRLW 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542417 353 DMRTGKVVKGYKATIQQTLDILFLQEGSEFLSStdastrdSADRTIIAWDFRTAAKISNQIFHERYTCpSLALHPrepvf 432
Cdd:cd00200   79 DLETGECVRTLTGHTSYVSSVAFSPDGRILSSS-------SRDKTIKVWDVETGKCLTTLRGHTDWVN-SVAFSP----- 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542417 433 laqtNGNYLALFSS-----VWPYR-MSRRRRYEGHKVEGYAVgcECSPCGDLLVTGSADGRVLMFSFRTASRACTLQGHT 506
Cdd:cd00200  146 ----DGTFVASSSQdgtikLWDLRtGKCVATLTGHTGEVNSV--AFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHE 219

                        250       260
                 ....*....|....*....|....*...
gi 755542417 507 QACLGTTYHPVlPSVLGTCSWGGDIKIW 534
Cdd:cd00200  220 NGVNSVAFSPD-GYLLASGSEDGTIRVW 246
WD40 COG2319
WD40 repeat [General function prediction only];
229-534 4.84e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 92.28  E-value: 4.84e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542417 229 VLFHLRGHRGPVNSIQWCPVfckSHMLLSASMDKTFKVWNAvDSGHCLQTYSVHSEAVRAARWSPCGRRILSGGFDFALH 308
Cdd:COG2319   28 LLLLLLGLAAAVASLAASPD---GARLAAGAGDLTLLLLDA-AAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVR 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542417 309 LTDLETGT--QVFSGQSDfRVTTLKFHPkDHNVFLCGGFSSEIKAWDMRTGKVVKGYKATIQQTLDILFLQEGSEFLSSt 386
Cdd:COG2319  104 LWDLATGLllRTLTGHTG-AVRSVAFSP-DGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASG- 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542417 387 dastrdSADRTIIAWDFRTAAKISNQIFHERYTCpSLALHPrepvflaqtNGNYLALFSS-----VW-PYRMSRRRRYEG 460
Cdd:COG2319  181 ------SDDGTVRLWDLATGKLLRTLTGHTGAVR-SVAFSP---------DGKLLASGSAdgtvrLWdLATGKLLRTLTG 244

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755542417 461 HKVEGYAVgcECSPCGDLLVTGSADGRVLMFSFRTASRACTLQGHTQACLGTTYHPVlPSVLGTCSWGGDIKIW 534
Cdd:COG2319  245 HSGSVRSV--AFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPD-GKLLASGSDDGTVRLW 315
WD40 COG2319
WD40 repeat [General function prediction only];
227-356 1.27e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 91.13  E-value: 1.27e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542417 227 KKVLFHLRGHRGPVNSIQWCPvfcKSHMLLSASMDKTFKVWNaVDSGHCLQTYSVHSEAVRAARWSPCGRRILSGGFDFA 306
Cdd:COG2319  278 GELLRTLTGHSGGVNSVAFSP---DGKLLASGSDDGTVRLWD-LATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGT 353

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 755542417 307 LHLTDLETGTQV--FSGQSDfRVTTLKFHPkDHNVFLCGGFSSEIKAWDMRT 356
Cdd:COG2319  354 VRLWDLATGELLrtLTGHTG-AVTSVAFSP-DGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
255-534 2.36e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 68.78  E-value: 2.36e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542417 255 LLSASMDKTFKVWnAVDSGHCLQTYSVHSEAVRAARWSPCGRRILSGGFDFALHLTDLETGTQVFSGQSDFRVTTLKFHP 334
Cdd:COG2319    9 LAAASADLALALL-AAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFS 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542417 335 KDHNVFLCGGFSSEIKAWDMRTGKVVKGYKATIQQTLDILFLQEGSEFLSStdastrdSADRTIIAWDFRTAAKISNQIF 414
Cdd:COG2319   88 PDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASG-------SADGTVRLWDLATGKLLRTLTG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542417 415 HERYTcPSLALHPrepvflaqtNGNYLALFSS-----VW-PYRMSRRRRYEGHKVEGYAVgcECSPCGDLLVTGSADGRV 488
Cdd:COG2319  161 HSGAV-TSVAFSP---------DGKLLASGSDdgtvrLWdLATGKLLRTLTGHTGAVRSV--AFSPDGKLLASGSADGTV 228

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 755542417 489 LMFSFRTASRACTLQGHTQACLGTTYHPVlPSVLGTCSWGGDIKIW 534
Cdd:COG2319  229 RLWDLATGKLLRTLTGHSGSVRSVAFSPD-GRLLASGSADGTVRLW 273
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 226-268 8.53e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 8.53e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 755542417   226 PKKVLFHLRGHRGPVNSIQWCPvfcKSHMLLSASMDKTFKVWN 268
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP---DGKYLASGSDDGTIKLWD 40
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 456-535 2.69e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 49.26  E-value: 2.69e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542417 456 RRYEGHKVEgyAVGCECSPCGDLLVTGSADGRVLMFSFRTASRACTLQGHTQACLGTTYHPvLPSVLGTCSWGGDIKIWH 535
Cdd:cd00200   45 RTLKGHTGP--VRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSP-DGRILSSSSRDKTIKVWD 121
WD40 pfam00400
WD domain, G-beta repeat;
227-268 1.81e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 1.81e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 755542417  227 KKVLFHLRGHRGPVNSIQWCPvfcKSHMLLSASMDKTFKVWN 268
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSP---DGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 272-311 7.72e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.99  E-value: 7.72e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 755542417   272 SGHCLQTYSVHSEAVRAARWSPCGRRILSGGFDFALHLTD 311
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00420 PTZ00420
coronin; Provisional
 216-335 3.01e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 43.40  E-value: 3.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542417 216 LNSQYRETTVPKkvlfhLRGHRGPVNSIQWCPvfCKSHMLLSASMDKTFKVW---------NAVDSGHCLqtYSVHSEAV 286
Cdd:PTZ00420  58 LENQMRKPPVIK-----LKGHTSSILDLQFNP--CFSEILASGSEDLTIRVWeiphndesvKEIKDPQCI--LKGHKKKI 128

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 755542417 287 RAARWSPCGRRIL-SGGFDFALHLTDLETGTQVFSGQSDFRVTTLKFHPK 335
Cdd:PTZ00420 129 SIIDWNPMNYYIMcSSGFDSFVNIWDIENEKRAFQINMPKKLSSLKWNIK 178
PTZ00421 PTZ00421
coronin; Provisional
 230-355 1.29e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 41.42  E-value: 1.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755542417 230 LFHLRGHRGPVNSIQWCPvfCKSHMLLSASMDKTFKVWNaVDSGHCLQTYSVHSEAVRAARWSPCGRRILSGGFDFALHL 309
Cdd:PTZ00421 118 IVHLQGHTKKVGIVSFHP--SAMNVLASAGADMVVNVWD-VERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNI 194

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 755542417 310 TDLETGTQVFSGQSDFRVTTLK-FHPKDHNVFLCGGFSS----EIKAWDMR 355
Cdd:PTZ00421 195 IDPRDGTIVSSVEAHASAKSQRcLWAKRKDLIITLGCSKsqqrQIMLWDTR 245
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 227-268 1.50e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 40.78  E-value: 1.50e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 755542417 227 KKVLFHLRGHRGPVNSIQWCPvfcKSHMLLSASMDKTFKVWN 268
Cdd:cd00200  251 GECVQTLSGHTNSVTSLAWSP---DGKRLASGSADGTIRIWD 289
WD40 pfam00400
WD domain, G-beta repeat;
273-311 1.96e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 1.96e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 755542417  273 GHCLQTYSVHSEAVRAARWSPCGRRILSGGFDFALHLTD 311
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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