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Conserved domains on  [gi|755545493|ref|XP_011242837|]
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zinc finger protein 874b isoform X2 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204268)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

CATH:  3.30.160.60
Gene Ontology:  GO:0003700|GO:0046872
PubMed:  22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
2-56 2.05e-25

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 98.05  E-value: 2.05e-25
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 755545493     2 LSFRDVAIDFSPEERDYLGPAQWDLYRDVMLENYSHLVFLGLAVAKPYLVTFLEQ 56
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQ 55
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
140-420 2.00e-06

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.08  E-value: 2.00e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755545493 140 KTLSSRSSLLIHQKYHTDEKTYKCEKCGKRFLRSSHLQHHQKIHTGEKPYKCEECDKAFLHHSYLRKHQAVHTGEKPYKC 219
Cdd:COG5048  178 KDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSA 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755545493 220 EECGNSFYYPAMLKQHQRIHSGEkldkceecgkvfssafflNQHKGIDsieKRYKCQECGKSFCYRSYLREHYR--RHSG 297
Cdd:COG5048  258 SESPRSSLPTASSQSSSPNESDS------------------SSEKGFS---LPIKSKQCNISFSRSSPLTRHLRsvNHSG 316

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755545493 298 EY--PYKCEE--CGKGFSRSSKLQEHQTIHTGVKPYKC--EECEKCFSSFTSLKRHQIIH-----SEDTPHECV--ECGK 364
Cdd:COG5048  317 ESlkPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLsnSCIR 396

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 755545493 365 RFSSSSRLQEHQKIHTEEKP--YKCEECDKAFLYHSFLRRHRAVHTREKPYTCEECGK 420
Cdd:COG5048  397 NFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
2-56 2.05e-25

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 98.05  E-value: 2.05e-25
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 755545493     2 LSFRDVAIDFSPEERDYLGPAQWDLYRDVMLENYSHLVFLGLAVAKPYLVTFLEQ 56
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQ 55
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 1-42 3.93e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 80.21  E-value: 3.93e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 755545493    1 MLSFRDVAIDFSPEERDYLGPAQWDLYRDVMLENYSHLVFLG 42
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 2-41 1.54e-14

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 67.19  E-value: 1.54e-14
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 755545493   2 LSFRDVAIDFSPEERDYLGPAQWDLYRDVMLENYSHLVFL 41
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
140-420 2.00e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.08  E-value: 2.00e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755545493 140 KTLSSRSSLLIHQKYHTDEKTYKCEKCGKRFLRSSHLQHHQKIHTGEKPYKCEECDKAFLHHSYLRKHQAVHTGEKPYKC 219
Cdd:COG5048  178 KDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSA 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755545493 220 EECGNSFYYPAMLKQHQRIHSGEkldkceecgkvfssafflNQHKGIDsieKRYKCQECGKSFCYRSYLREHYR--RHSG 297
Cdd:COG5048  258 SESPRSSLPTASSQSSSPNESDS------------------SSEKGFS---LPIKSKQCNISFSRSSPLTRHLRsvNHSG 316

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755545493 298 EY--PYKCEE--CGKGFSRSSKLQEHQTIHTGVKPYKC--EECEKCFSSFTSLKRHQIIH-----SEDTPHECV--ECGK 364
Cdd:COG5048  317 ESlkPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLsnSCIR 396

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 755545493 365 RFSSSSRLQEHQKIHTEEKP--YKCEECDKAFLYHSFLRRHRAVHTREKPYTCEECGK 420
Cdd:COG5048  397 NFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
zf-H2C2_2 pfam13465
Zinc-finger double domain;
371-396 1.42e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.42e-03
                          10        20
                  ....*....|....*....|....*.
gi 755545493  371 RLQEHQKIHTEEKPYKCEECDKAFLY 396
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
2-56 2.05e-25

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 98.05  E-value: 2.05e-25
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 755545493     2 LSFRDVAIDFSPEERDYLGPAQWDLYRDVMLENYSHLVFLGLAVAKPYLVTFLEQ 56
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQ 55
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 1-42 3.93e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 80.21  E-value: 3.93e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 755545493    1 MLSFRDVAIDFSPEERDYLGPAQWDLYRDVMLENYSHLVFLG 42
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 2-41 1.54e-14

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 67.19  E-value: 1.54e-14
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 755545493   2 LSFRDVAIDFSPEERDYLGPAQWDLYRDVMLENYSHLVFL 41
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
140-420 2.00e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.08  E-value: 2.00e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755545493 140 KTLSSRSSLLIHQKYHTDEKTYKCEKCGKRFLRSSHLQHHQKIHTGEKPYKCEECDKAFLHHSYLRKHQAVHTGEKPYKC 219
Cdd:COG5048  178 KDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSA 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755545493 220 EECGNSFYYPAMLKQHQRIHSGEkldkceecgkvfssafflNQHKGIDsieKRYKCQECGKSFCYRSYLREHYR--RHSG 297
Cdd:COG5048  258 SESPRSSLPTASSQSSSPNESDS------------------SSEKGFS---LPIKSKQCNISFSRSSPLTRHLRsvNHSG 316

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755545493 298 EY--PYKCEE--CGKGFSRSSKLQEHQTIHTGVKPYKC--EECEKCFSSFTSLKRHQIIH-----SEDTPHECV--ECGK 364
Cdd:COG5048  317 ESlkPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLsnSCIR 396

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 755545493 365 RFSSSSRLQEHQKIHTEEKP--YKCEECDKAFLYHSFLRRHRAVHTREKPYTCEECGK 420
Cdd:COG5048  397 NFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 325-404 1.60e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.94  E-value: 1.60e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755545493 325 GVKPYKCE--ECEKCFSSFTSLKRHQIiHSEdtphecveCGKRFSSSSRLQEHQKIHTEEKPYKCEECDKAFLYHSFLRR 402
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHML-HGH--------QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ..
gi 755545493 403 HR 404
Cdd:COG5189  417 HR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 381-438 4.33e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.40  E-value: 4.33e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755545493 381 EEKPYKCE--ECDKAFLYHSFLRRHR-------------------AVHTREKPYTCEECGKCYTSFTSLKRHQTiHSVD 438
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHMlhghqnqklhenpspekmnIFSAKDKPYRCEVCDKRYKNLNGLKYHRK-HSHD 423
zf-H2C2_2 pfam13465
Zinc-finger double domain;
371-396 1.42e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.42e-03
                          10        20
                  ....*....|....*....|....*.
gi 755545493  371 RLQEHQKIHTEEKPYKCEECDKAFLY 396
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
175-200 1.95e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 1.95e-03
                          10        20
                  ....*....|....*....|....*.
gi 755545493  175 HLQHHQKIHTGEKPYKCEECDKAFLH 200
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
157-442 1.95e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.45  E-value: 1.95e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755545493 157 DEKTYKCEKCGKRFLRSSHLQHHQKIHTGEKPYKC--EECDKAF--------------LHHSYLRKHQAVHTGEKPYKCE 220
Cdd:COG5048   30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFsrplelsrhlrthhNNPSDLNSKSLPLSNSKASSSS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755545493 221 E--CGNSFYYPAMLKQH------------------------------------QRIHSGEKLDKCEECGKVFSSAFFLNQ 262
Cdd:COG5048  110 LssSSSNSNDNNLLSSHslppssrdpqlpdllsisnlrnnplpgnnsssvntpQSNSLHPPLPANSLSKDPSSNLSLLIS 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755545493 263 HKGIDSIEKRYKCQECGKSFCYRSYLREHYRRHSgEYPYKCEECGKGFSRSSKLQEHQTIHTGVKPYKCEECEKCFSSFT 342
Cdd:COG5048  190 SNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTA 268

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755545493 343 SLKRHQIIHSE-------DTPHECVECGKRFSSSSRLQEHQ--KIHTEE--KPYKCEE--CDKAFLYHSFLRRHRAVHTR 409
Cdd:COG5048  269 SSQSSSPNESDsssekgfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTS 348

                        330       340       350
                 ....*....|....*....|....*....|....*
gi 755545493 410 EKPYTC--EECGKCYTSFTSLKRHQTIHSVDTPHE 442
Cdd:COG5048  349 ISPAKEklLNSSSKFSPLLNNEPPQSLQQYKDLKN 383
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 154-240 2.38e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 2.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755545493 154 YHTDEKTYKCE--KCGKRFLRSSHLQHHqKIHTGEKPYKCEECDKAflhhsylrKHQAVHTGEKPYKCEECGNSFYYPAM 231
Cdd:COG5189  343 KVKDGKPYKCPveGCNKKYKNQNGLKYH-MLHGHQNQKLHENPSPE--------KMNIFSAKDKPYRCEVCDKRYKNLNG 413


                 ....*....
gi 755545493 232 LKQHqRIHS 240
Cdd:COG5189  414 LKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
203-228 3.80e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 3.80e-03
                          10        20
                  ....*....|....*....|....*.
gi 755545493  203 YLRKHQAVHTGEKPYKCEECGNSFYY 228
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 129-207 5.13e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 38.93  E-value: 5.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755545493 129 GDKPYKCK--ECHKTLSSRSSLlihqKYHTDEKtykceKCGKRFLRSSHLQHHQKIHTGEKPYKCEECDKAFLHHSYLRK 206
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGL----KYHMLHG-----HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 .
gi 755545493 207 H 207
Cdd:COG5189  417 H 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
316-340 6.65e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 6.65e-03
                          10        20
                  ....*....|....*....|....*
gi 755545493  316 LQEHQTIHTGVKPYKCEECEKCFSS 340
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
287-312 7.63e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 7.63e-03
                          10        20
                  ....*....|....*....|....*.
gi 755545493  287 YLREHYRRHSGEYPYKCEECGKGFSR 312
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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