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Conserved domains on  [gi|755547671|ref|XP_011243225|]
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alpha-1A adrenergic receptor isoform X1 [Mus musculus]

Protein Classification

7tmA_alpha1A_AR domain-containing protein( domain architecture ID 11607400)

7tmA_alpha1A_AR domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
27-337 7.46e-178

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


:

Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 498.26  E-value: 7.46e-178
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVD 106
Cdd:cd15325    1 IVLGVILGGFILFGVLGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQAPEDETICQINEEPGYVL 186
Cdd:cd15325   81 VLCCTASIMSLCIISIDRYIGVSYPLRYPSIMTERRGLLALLCVWVLSLVISIGPLFGWKEPAPEDETICQITEEPGYAL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 187 FSALGSFYVPLTIILVMYCRVYVVAkresrglksglktdksdseqvtlrihrknvpaegsgvssaknkthfsvrlLKFSR 266
Cdd:cd15325  161 FSALGSFYLPLAIILVMYCRVYVVA--------------------------------------------------LKFSR 190
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755547671 267 EKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15325  191 EKKAAKTLGIVVGCFVLCWLPFFLVMPIGSIFPAYKPSDTVFKITFWLGYFNSCINPIIYPCSSQEFKKAF 261
 
Name Accession Description Interval E-value
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
27-337 7.46e-178

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 498.26  E-value: 7.46e-178
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVD 106
Cdd:cd15325    1 IVLGVILGGFILFGVLGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQAPEDETICQINEEPGYVL 186
Cdd:cd15325   81 VLCCTASIMSLCIISIDRYIGVSYPLRYPSIMTERRGLLALLCVWVLSLVISIGPLFGWKEPAPEDETICQITEEPGYAL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 187 FSALGSFYVPLTIILVMYCRVYVVAkresrglksglktdksdseqvtlrihrknvpaegsgvssaknkthfsvrlLKFSR 266
Cdd:cd15325  161 FSALGSFYLPLAIILVMYCRVYVVA--------------------------------------------------LKFSR 190
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755547671 267 EKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15325  191 EKKAAKTLGIVVGCFVLCWLPFFLVMPIGSIFPAYKPSDTVFKITFWLGYFNSCINPIIYPCSSQEFKKAF 261
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
43-326 1.80e-79

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 425413 [Multi-domain]  Cd Length: 257  Bit Score: 247.22  E-value: 1.80e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671   43 GNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEIL-GYWAFGRVFCNIWAAVDVLCCTASIMGLCIIS 121
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFGLLTLPFWLVYYLLhGDWPFGSALCKLVGALFYVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  122 IDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPL-FGWRQQAPEDE-TICQIN------EEPGYVLFSALGSF 193
Cdd:pfam00001  81 IDRYLAIVHPLRYRRIRTPRRAKVLILLVWVLALLLSLPPLlFGWTLTVPEGNvTVCFIDfpevlsKPVSYTLLSSVLGF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  194 YVPLTIILVMYCRVYVVAKRESRGLKSGLKTDksdseqvtlrihrknvpaegsgvssaknkthfsvrllkfSREKKAAKT 273
Cdd:pfam00001 161 LLPLLVILVCYTRIIRTLRKSASKQKSEERTQ---------------------------------------RRERKALKT 201
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 755547671  274 LGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPETVFKIVF---WLGYLNSCINPIIY 326
Cdd:pfam00001 202 LAVVVVVFILCWLPYHIVNLLDSLALDCELSRLLDKALSitlWLAYVNSCLNPIIY 257
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
25-343 3.13e-25

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 105.63  E-value: 3.13e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  25 KAILLGVILGGLIIFGVLGNILVILsVACHRHLHSVTHYYIVNLAVADLLLTSTvLPFSAIFEILGYWAFGRVFCNIWAA 104
Cdd:PHA03087  39 NSTILIVVYSTIFFFGLVGNIIVIY-VLTKTKIKTPMDIYLLNLAVSDLLFVMT-LPFQIYYYILFQWSFGEFACKIVSG 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 105 VDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQAPEDETICQI------ 178
Cdd:PHA03087 117 LYYIGFYNSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETTPILFVYTTKKDHETLICCMfynnkt 196
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 179 NEEPGYVLF--SALGsFYVPLTIILVMYCRVYVVAKResrglksglktdksdseqvtlrihrknvpaegsgvsSAKNKth 256
Cdd:PHA03087 197 MNWKLFINFeiNIIG-MLIPLTILLYCYSKILITLKG------------------------------------INKSK-- 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 257 fsvrllkfsREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFP-NFKPPETVFKIVFWLGY-------LNSCINPIIYPC 328
Cdd:PHA03087 238 ---------KNKKAIKLVLIIVILFVIFWLPFNVSVFVYSLHIlHFKSGCKAVKYIQYALHvteiislSHCCINPLIYAF 308
                        330
                 ....*....|....*
gi 755547671 329 SSQEFKKAFQNVLRI 343
Cdd:PHA03087 309 VSEFFNKHKKKSLKL 323
 
Name Accession Description Interval E-value
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
27-337 7.46e-178

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 498.26  E-value: 7.46e-178
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVD 106
Cdd:cd15325    1 IVLGVILGGFILFGVLGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQAPEDETICQINEEPGYVL 186
Cdd:cd15325   81 VLCCTASIMSLCIISIDRYIGVSYPLRYPSIMTERRGLLALLCVWVLSLVISIGPLFGWKEPAPEDETICQITEEPGYAL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 187 FSALGSFYVPLTIILVMYCRVYVVAkresrglksglktdksdseqvtlrihrknvpaegsgvssaknkthfsvrlLKFSR 266
Cdd:cd15325  161 FSALGSFYLPLAIILVMYCRVYVVA--------------------------------------------------LKFSR 190
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755547671 267 EKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15325  191 EKKAAKTLGIVVGCFVLCWLPFFLVMPIGSIFPAYKPSDTVFKITFWLGYFNSCINPIIYPCSSQEFKKAF 261
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
27-337 1.47e-155

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 441.54  E-value: 1.47e-155
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVD 106
Cdd:cd15062    1 IVVGVALGAFILFAIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTVLPFSATLEVLGYWAFGRIFCDVWAAVD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQAPEDETICQINEEPGYVL 186
Cdd:cd15062   81 VLCCTASIMSLCVISVDRYIGVRYPLNYPTIVTARRATVALLIVWVLSLVISIGPLLGWKEPAPADEQACGVNEEPGYVL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 187 FSALGSFYVPLTIILVMYCRVYVVAkresrglksglktdksdseqvtlrihrknvpaegsgvssaknkthfsvrlLKFSR 266
Cdd:cd15062  161 FSSLGSFYLPLAIILVMYCRVYVVA--------------------------------------------------FKFSR 190
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755547671 267 EKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15062  191 EKKAAKTLGIVVGAFVLCWFPFFVVLPLGSLFSTLKPPEPVFKVVFWLGYFNSCLNPIIYPCSSREFKRAF 261
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
27-337 9.53e-148

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 421.61  E-value: 9.53e-148
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVD 106
Cdd:cd15326    1 ILLGLVLGAFILFAIVGNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTVLPFSATLEILGYWVFGRIFCDIWAAVD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQAPEDETICQINEEPGYVL 186
Cdd:cd15326   81 VLCCTASILSLCAISIDRYIGVRHSLQYPTIVTRKRAILALLGVWVLSTVISIGPLLGWKEPAPPDDKVCEITEEPFYAL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 187 FSALGSFYVPLTIILVMYCRVYVVAkresrglksglktdksdseqvtlrihrknvpaegsgvssaknkthfsvrlLKFSR 266
Cdd:cd15326  161 FSSLGSFYIPLIVILVMYCRVYIVA--------------------------------------------------LKFSR 190
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755547671 267 EKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15326  191 EKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSHLKPPETLFKIIFWLGYFNSCLNPIIYPCSSKEFKRAF 261
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
29-337 3.59e-137

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 395.05  E-value: 3.59e-137
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  29 LGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVL 108
Cdd:cd15327    3 VGVFLAIFILMAIVGNILVILSVACNRHLQTVTNYFIVNLAIADLLLSTTVLPFSATLEVLGFWAFGRVFCDIWAAVDVL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 109 CCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQAPEDETICQINEEPGYVLFS 188
Cdd:cd15327   83 CCTASILSLCVISVDRYVGVKHSLKYPTIMTERKAGVILVLLWVSSMVISIGPLLGWKEPPPPDESICSITEEPGYALFS 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 189 ALGSFYVPLTIILVMYCRVYVVAkresrglksglktdksdseqvtlrihrknvpaegsgvssaknkthfsvrlLKFSREK 268
Cdd:cd15327  163 SLFSFYLPLMVILVMYFRVYVVA--------------------------------------------------LKFSREK 192
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755547671 269 KAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15327  193 KAAKTLAIVVGVFILCWFPFFFVLPLGSFFPALKPSEMVFKVIFWLGYFNSCVNPIIYPCSSKEFKRAF 261
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
28-337 6.64e-114

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 335.69  E-value: 6.64e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  28 LLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDV 107
Cdd:cd14967    1 LLAVFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALDV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 108 LCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWR--QQAPEDETICQINEEPGYV 185
Cdd:cd14967   81 LCCTASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLISLPPLVGWRdeTQPSVVDCECEFTPNKIYV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 186 LFSALGSFYVPLTIILVMYCRVYVVAKresrglksglktdksdseqvtlrihrknvpaegsgvssaknkthfsvrllkfs 265
Cdd:cd14967  161 LVSSVISFFIPLLIMIVLYARIFRVAR----------------------------------------------------- 187
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755547671 266 REKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd14967  188 RELKAAKTLAIIVGAFLLCWLPFFIIYLVSAFCPPDCVPPILYAVFFWLGYLNSALNPIIYALFNRDFRRAF 259
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
27-337 8.95e-102

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 304.64  E-value: 8.95e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVD 106
Cdd:cd15064    1 VLISVLLSLIILATILGNALVIAAILLTRKLHTPANYLIASLAVADLLVAVLVMPLSAVYELTGRWILGQVLCDIWISLD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQAPEDETICQINEEPGYVL 186
Cdd:cd15064   81 VTCCTASILHLCVIALDRYWAITDAVEYAHKRTPKRAAVMIALVWTLSICISLPPLFGWRTPDSEDPSECLISQDIGYTI 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 187 FSALGSFYVPLTIILVMYCRVYVVAKresrglksglktdksdseqvtlrihrknvpaegsgvssaknkthfsvrllkfsR 266
Cdd:cd15064  161 FSTFGAFYIPLLLMLILYWKIYRAAA-----------------------------------------------------R 187
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755547671 267 EKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15064  188 ERKAAKTLGIILGAFIVCWLPFFLVALIVPLCSHCWIPLALKSFFLWLGYFNSLINPLIYTFFNKDFRKAF 258
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
28-337 1.94e-90

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 275.77  E-value: 1.94e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  28 LLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILG-YWAFGRVFCNIWAAVD 106
Cdd:cd15067    1 LLGVVLSLFCLVTVAGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVMPFSILHEMTGgYWLFGRDWCDVWHSFD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWR--QQAPEDETICQINEEPGY 184
Cdd:cd15067   81 VLASTASILNLCVISLDRYWAITDPISYPSRMTKRRALIMIALVWICSALISFPAIAWWRavDPGPSPPNQCLFTDDSGY 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 185 VLFSALGSFYVPLTIILVMYCRVYVVAkresrglksglktdksdseqvtlrihrknvpaegsgvssaknkthfsvrllkf 264
Cdd:cd15067  161 LIFSSCVSFYIPLVVMLFTYYRIYRAA----------------------------------------------------- 187
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755547671 265 SREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPN--FKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15067  188 AKEQKAAKTLGIVMGVFILCWLPFFVTNILIGFCPSncVSNPDILFPLVTWLGYINSGMNPIIYACSSRDFRRAF 262
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
27-337 6.73e-89

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 271.91  E-value: 6.73e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVD 106
Cdd:cd15059    1 VAISSIVSVVILLIIVGNVLVIVAVLTSRKLRAPQNWFLVSLAVADILVGLLIMPFSLVNELMGYWYFGSVWCEIWLALD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQAPEDETI--CQINEEPGY 184
Cdd:cd15059   81 VLFCTASIVNLCAISLDRYWSVTQAVEYNLKRTPRRAKAMIAAVWIISAVISLPPLFGWKDEQPWHGAEpqCELSDDPGY 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 185 VLFSALGSFYVPLTIILVMYCRVYVVAKResrglksglktdksdseqvtlrihrknvpaegsgvssaknkthfsvrllkf 264
Cdd:cd15059  161 VLFSSIGSFYIPLLIMIIVYARIYRAAKR--------------------------------------------------- 189
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755547671 265 sREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15059  190 -KERRFTLVLGVVMGAFVLCWLPFFFTYPLVVVCKTCGVPELLFKFFFWLGYCNSALNPVIYTIFNKDFRRAF 261
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
27-337 1.10e-88

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 271.07  E-value: 1.10e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVD 106
Cdd:cd15329    1 VLIGIVLLIIILGTVVGNALVIIAVCLVKKLRTPSNYLIVSLAVSDLLVALLVMPLAIIYELSGYWPFGEILCDVWISFD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWrQQAPEDETICQINEEPGYVL 186
Cdd:cd15329   81 VLLCTASILNLCAISVDRYLVITRPLTYAVKRTPKRMALMIAIVWLLSALISIPPLFGW-KNKVNDPGVCQVSQDFGYQI 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 187 FSALGSFYVPLTIILVMYCRVYVVAKresrglksglktdksdseqvtlrihrknvpaegsgvssaknkthfsvrllkfsR 266
Cdd:cd15329  160 YATFGAFYIPLIVMLVLYYKIYRAAK-----------------------------------------------------S 186
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755547671 267 EKKAAKTLGIVVGCFVLCWLPFF---LVMPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15329  187 ERKAIKTLGIIMGAFTLCWLPFFilaLLRPFLKPIKCSCIPLWLSRLFLWLGYANSFLNPIIYAKFNREFRTPF 260
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
27-337 1.49e-88

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 271.90  E-value: 1.49e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVD 106
Cdd:cd15051    1 IVLGVVLAVIILLTVIGNVLVCLAVAVNRRLRNLTNYFIVSLAVTDLLLGLLVLPFSAIYELRGEWPLGPVFCNIYISLD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPL-FGW-----RQQAPEDETICQINE 180
Cdd:cd15051   81 VMLCTASILNLFAISLDRYLAITAPLRYPSRVTPRRVAIALAAIWVVSLAVSFLPIhLGWntpdgRVQNGDTPNQCRFEL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 181 EPGYVLFSALGSFYVPLTIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEqvtlrihrknvpaegsgvssaknKTHFSVr 260
Cdd:cd15051  161 NPPYVLLVAIGTFYLPLLIMCGVYLRIFRIAREQAKRINALTPASTANSS-----------------------KSAATA- 216
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755547671 261 llkfsREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNfKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15051  217 -----REHKATVTLAAVLGAFIICWFPYFTYFTYRGLCGD-NINETALSVVLWLGYANSALNPILYAFLNRDFRRAF 287
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
27-337 4.76e-87

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 268.53  E-value: 4.76e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHS-VTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRvFCNIWAAV 105
Cdd:cd15057    1 IITGCILYLLVLLTLLGNALVIAAVLRFRHLRSkVTNYFIVSLAVSDLLVAILVMPWAAVNEVAGYWPFGS-FCDVWVSF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 106 DVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPL-FGWRQQAP--------EDETIC 176
Cdd:cd15057   80 DIMCSTASILNLCVISVDRYWAISSPFRYERRMTRRRAFIMIAVAWTLSALISFIPVqLGWHRADDtsealalyADPCQC 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 177 QINEEPGYVLFSALGSFYVPLTIILVMYCRVYVVAKRESRGLKSglktdksdseqvtlrihrknvpAEGSGVSSAKNKTH 256
Cdd:cd15057  160 DSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIARRQIRRIAA----------------------LERAAQESTNPDSS 217
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 257 FSVRllkFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKP-----PETVFKIVFWLGYLNSCINPIIYpCSSQ 331
Cdd:cd15057  218 LRSS---LRRETKALKTLSIIMGVFVCCWLPFFILNCVLPFCDLRTAqfpcvPDTTFIVFVWLGWANSSLNPIIY-AFNA 293

                 ....*.
gi 755547671 332 EFKKAF 337
Cdd:cd15057  294 DFRKAF 299
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
28-337 9.50e-87

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 267.68  E-value: 9.50e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  28 LLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDV 107
Cdd:cd15065    1 LIGIFLSLIIVLAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLVMTFAVVNDLLGYWLFGETFCNIWISFDV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 108 LCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLF-GWRQQAPE----------DETIC 176
Cdd:cd15065   81 MCSTASILNLCAISLDRYIHIKKPLKYERWMTTRRALVVIASVWILSALISFLPIHlGWHRLSQDeikglnhasnPKPSC 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 177 QINEEPGYVLFSALGSFYVPLTIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNvpaEGSGVSsaknkth 256
Cdd:cd15065  161 ALDLNPTYAVVSSLISFYIPCLVMLLIYSRLYLYARKHVVNIKSQKLPSESGSKFQVPSLSSKH---NNQGVS------- 230
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 257 fsvrllkfsrEKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPEtVFKIVFWLGYLNSCINPIIYPCSSQEFKKA 336
Cdd:cd15065  231 ----------DHKAAVTLGIIMGVFLICWLPFFIINIIAAFCKTCIPPK-CFKILTWLGYFNSCLNPIIYSIFNSEFRRA 299

                 .
gi 755547671 337 F 337
Cdd:cd15065  300 F 300
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
28-337 5.00e-81

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 251.51  E-value: 5.00e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  28 LLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDV 107
Cdd:cd15061    1 ILISFLILAIIFTIFGNLLVILAVATTRRLRTITNCYIVSLATADLLVGVLVLPLAIIRQLLGYWPLGSHLCDFWISLDV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 108 LCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQAPEDETICQINEEPGYVLF 187
Cdd:cd15061   81 LLCTASILNLCCISLDRYFAITYPLKYRTKRSRRLAITMILAVWVISLLITSPPLVGPSWHGRRGLGSCYYTYDKGYRIY 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 188 SALGSFYVPLTIILVMYCRVYVVAKresrglksglktdksdseqvtlrihrknvpaegsgvssaknkthfsvrllkfsRE 267
Cdd:cd15061  161 SSMGSFFLPLLLMLFVYLRIFRVIA-----------------------------------------------------KE 187
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 268 KKAAKTLGIVVGCFVLCWLPFFLvMPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15061  188 RKTAKTLAIVVGCFIVCWLPFFI-MYLIEPFCDCQFSEALSTAFTWLGYFNSVINPFIYAFYNKDFRRAF 256
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
31-337 9.49e-81

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 250.88  E-value: 9.49e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  31 VILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCC 110
Cdd:cd15063    5 LVLTFLNVLVVLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVLPFSAVNEVLDVWIFGHTWCQIWLAVDVWMC 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 111 TASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQ---------APEDETICQINEE 181
Cdd:cd15063   85 TASILNLCAISLDRYLAITRPIRYPSLMSTKRAKCLIAGVWVLSFVICFPPLVGWNDGkdgimdysgSSSLPCTCELTNG 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 182 PGYVLFSALGSFYVPLTIILVMYCRVYVVAkresrglksglktdksdseqvtlrihrknvpaegsgvssaknkthfsvrl 261
Cdd:cd15063  165 RGYVIYSALGSFYIPMLVMLFFYFRIYRAA-------------------------------------------------- 194
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755547671 262 lkfSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPeTVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15063  195 ---RMETKAAKTVAIIVGCFIFCWLPFFTVYLVRAFCEDCIPP-LLFSVFFWLGYCNSALNPCIYALFSRDFRFAF 266
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
43-326 1.80e-79

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 425413 [Multi-domain]  Cd Length: 257  Bit Score: 247.22  E-value: 1.80e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671   43 GNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEIL-GYWAFGRVFCNIWAAVDVLCCTASIMGLCIIS 121
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFGLLTLPFWLVYYLLhGDWPFGSALCKLVGALFYVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  122 IDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPL-FGWRQQAPEDE-TICQIN------EEPGYVLFSALGSF 193
Cdd:pfam00001  81 IDRYLAIVHPLRYRRIRTPRRAKVLILLVWVLALLLSLPPLlFGWTLTVPEGNvTVCFIDfpevlsKPVSYTLLSSVLGF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  194 YVPLTIILVMYCRVYVVAKRESRGLKSGLKTDksdseqvtlrihrknvpaegsgvssaknkthfsvrllkfSREKKAAKT 273
Cdd:pfam00001 161 LLPLLVILVCYTRIIRTLRKSASKQKSEERTQ---------------------------------------RRERKALKT 201
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 755547671  274 LGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPETVFKIVF---WLGYLNSCINPIIY 326
Cdd:pfam00001 202 LAVVVVVFILCWLPYHIVNLLDSLALDCELSRLLDKALSitlWLAYVNSCLNPIIY 257
7tmA_5-HT1A_invertebrates cd15331
serotonin receptor subtype 1A from invertebrates, member of the class A family of ...
27-337 3.55e-79

serotonin receptor subtype 1A from invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320454 [Multi-domain]  Cd Length: 261  Bit Score: 246.88  E-value: 3.55e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVD 106
Cdd:cd15331    1 VLTSIILGLLILATIIGNVFVIAAILLERSLQGVSNYLILSLAVADLMVAVLVMPLSAVYEVSQHWFLGPEVCDMWISMD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIGVSyPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQA----PEDETICQINEEP 182
Cdd:cd15331   81 VLCCTASILHLVAIALDRYWAVT-NIDYIRRRTAKRILIMIAVVWFVSLIISIAPLFGWKDEDdldrVLKTGVCLISQDY 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 183 GYVLFSALGSFYVPLTIILVMYCRVYVVAKresrglksglktdksdseqvtlrihrknvpaegsgvssaknkthfsvrll 262
Cdd:cd15331  160 GYTIFSTVGAFYVPLLLMIIIYWKIYQAAK-------------------------------------------------- 189
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755547671 263 kfsREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15331  190 ---RERKAARTLAIITGAFVVCWLPFFLVALVMPFCGAWQISRFLESFFLWLGYFNSLLNPIIYTIFSPDFRGAF 261
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
28-337 9.32e-79

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 247.36  E-value: 9.32e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  28 LLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDV 107
Cdd:cd15058    2 GLLLLLALIILAIVVGNLLVIIAIARTSRLQTMTNIFITSLACADLVMGLLVVPLGATIVVTGKWQLGNFWCELWTSVDV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 108 LCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFG--WRQQAPE------DETICQIN 179
Cdd:cd15058   82 LCVTASIETLCVIAVDRYIAITRPLRYQVLLTKRRARVIVCVVWIVSALVSFVPIMNqwWRANDPEandcyqDPTCCDFR 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 180 EEPGYVLFSALGSFYVPLTIILVMYCRVYVVAKRESRglksglKTDKSdseqvTLRIHRKNVPAEGSgvSSAKNKTHFSV 259
Cdd:cd15058  162 TNMAYAIASSVVSFYIPLLIMIFVYARVFLIATRQLQ------LIDKR-----RLRFQSECPAPQTT--SPEGKRSSGRR 228
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755547671 260 RLLKFS-REKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFkPPETVFKIVFWLGYLNSCINPIIYpCSSQEFKKAF 337
Cdd:cd15058  229 PSRLTVvKEHKALKTLGIIMGTFTLCWLPFFIANIINVFNRNL-PPGEVFLLLNWLGYINSGLNPIIY-CRSPEFRTAF 305
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
27-337 4.10e-77

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 241.57  E-value: 4.10e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVD 106
Cdd:cd15060    1 VVTTILLSVIIAFTIVGNILVILSVFTYRPLRIVQNFFIVSLAVADLAVAIFVLPLNVAYFLLGKWLFGIHLCQMWLTCD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWR--QQAPEDETICQINEEPGY 184
Cdd:cd15060   81 ILCCTASILNLCAIALDRYWAIHDPINYAQKRTLKRVLLMIVVVWALSALISVPPLIGWNdwPENFTETTPCTLTEEKGY 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 185 VLFSALGSFYVPLTIILVMYCRVYVVAkresrglksglktdksdseqvtlrihrknvpaegsgvssaknkthfsvrllkf 264
Cdd:cd15060  161 VIYSSSGSFFIPLLIMTIVYVKIFIAT----------------------------------------------------- 187
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755547671 265 SREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15060  188 SKERRAARTLGIIMGVFVVCWLPFFLMYVILPFCETCSPSAKVVNFITWLGYVNSALNPVIYTIFNLDFRRAF 260
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
27-337 5.13e-77

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 242.07  E-value: 5.13e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVD 106
Cdd:cd15055    1 VLLYIVLSSISLLTVLGNLLVIISISHFKQLHTPTNLLLLSLAVADFLVGLLVMPFSMIRSIETCWYFGDTFCKLHSSLD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQAPEDETI-----CQINEE 181
Cdd:cd15055   81 YILTSASIFNLVLIAIDRYVAVCDPLLYPTKITIRRVKICICLCWFVSALYSSVLLYDNLNQPGLIRYNscygeCVVVVN 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 182 PGYVLFSALGSFYVPLTIILVMYCRVYVVAKRESRglksglktdksdseqvTLRIHRKNVPAEGSGVSSAKNKthfsvrl 261
Cdd:cd15055  161 FIWGVVDLVLTFILPCTVMIVLYMRIFVVARSQAR----------------AIRSHTAQVSLEGSSKKVSKKS------- 217
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755547671 262 lkfsrEKKAAKTLGIVVGCFVLCWLPFFLVMPIGsffPNFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15055  218 -----ERKAAKTLGIVVGVFLLCWLPYYIVSLVD---PYISTPSSVFDVLIWLGYFNSCLNPLIYALFYPWFRKAL 285
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
30-337 1.03e-74

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 235.35  E-value: 1.03e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  30 GVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLC 109
Cdd:cd15066    3 GFAMTLIILAAIFGNLLVIISVMRHRKLRVITNYFVVSLAMADMLVALCAMTFNASVEITGRWMFGYFMCDVWNSLDVYF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 110 CTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLF-GW------RQQAPEDETICQINEEP 182
Cdd:cd15066   83 STASILHLCCISVDRYYAIVQPLEYPSKMTKRRVAIMLANVWISPALISFLPIFlGWytteehLQYRKTHPDQCEFVVNK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 183 GYVLFSALGSFYVPLTIILVMYCRVYVVAKresrglksglktdksdseqvtlrihrknvpaegsgvssaknkthfsvrll 262
Cdd:cd15066  163 IYALISSSVSFWIPCIVMIFTYYRIYLEAK-------------------------------------------------- 192
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755547671 263 kfsREKKAAKTLGIVVGCFVLCWLPFFL----VMPIGSFFPNfkpPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15066  193 ---REHKAAKTLGIIMGAFILCWLPFFLwyvtTTLCGDACPY---PPILVSILFWIGYFNSTLNPLIYAYFNRDFREAF 265
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
29-326 2.59e-74

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 234.88  E-value: 2.59e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  29 LGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVL 108
Cdd:cd00637    1 LAVLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 109 CCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQAPEDETIC-----QINEEPG 183
Cdd:cd00637   81 SLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCclcwpDLTLSKA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 184 YVLFSALGSFYVPLTIILVMYCRVYVVAKResrglksglktdksdseqvtlriHRKNVPAEGSGVSSAKNkthfsvrllk 263
Cdd:cd00637  161 YTIFLFVLLFLLPLLVIIVCYVRIFRKLRR-----------------------HRRRIRSSSSNSSRRRR---------- 207
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755547671 264 FSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFP-NFKPPETVFKIVFWLGYLNSCINPIIY 326
Cdd:cd00637  208 RRRERKVTKTLLIVVVVFLLCWLPYFILLLLDVFGPdPSPLPRILYFLALLLAYLNSAINPIIY 271
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
30-337 1.23e-73

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 232.62  E-value: 1.23e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  30 GVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEIL-GYWAFGRVFCNIWAAVDVL 108
Cdd:cd15053    4 ALFLLLLPLLTVFGNVLVIMSVFRERSLQTATNYFIVSLAVADLLVAILVMPFAVYVEVNgGKWYLGPILCDIYIAMDVM 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 109 CCTASIMGLCIISIDRYIGVSYPLRYptiVTQRRGVRALL---CVWALSLVISIGPLFGWRQQAPEDETICQInEEPGYV 185
Cdd:cd15053   84 CSTASIFNLCAISIDRYIAVTQPIKY---ARQKNSKRVLLtiaIVWVVSAAIACPLLFGLNNVPYRDPEECRF-YNPDFI 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 186 LFSALGSFYVPLTIILVMYCRVYVVAKresrglksglktdksdseqvtlrihrknvpaegsgvssaknkthfsvrllkfs 265
Cdd:cd15053  160 IYSSISSFYIPCIVMLLLYYRIFRALR----------------------------------------------------- 186
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755547671 266 REKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFK-----PPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15053  187 REKKATKTLAIVLGVFLFCWLPFFTLNILNAICPKLQnqschVGPALFSLTTWLGYVNSFLNPIIYTIFNIEFRKAF 263
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
27-337 1.85e-69

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 222.50  E-value: 1.85e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVD 106
Cdd:cd15314    1 VLLYIFLGLISLVTVCGNLLVIISIAHFKQLHTPTNYLILSLAVADLLVGGLVMPPSMVRSVETCWYFGDLFCKIHSSFD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLF------GWRQQAPEDETICQINE 180
Cdd:cd15314   81 ITLCTASILNLCFISIDRYYAVCQPLLYRSKITVRVVLVMILISWSVSALVGFGIIFlelnikGIYYNHVACEGGCLVFF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 181 EPGYVLFSALGSFYVPLTIILVMYCRVYVVAKRESRGLKSGLKTdksdseqvtlrihrknvpaegSGVSSAKnkthfsvr 260
Cdd:cd15314  161 SKVSSVVGSVFSFYIPAVIMLCIYLKIFLVAQRQARSIQSARTK---------------------SGASSSK-------- 211
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755547671 261 llkfsREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPeTVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15314  212 -----MERKATKTLAIVMGVFLLCWTPFFLCNIIDPFINYSIPP-VLIEVLNWLGYSNSTLNPFIYAFFYSWFRKAF 282
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
27-337 1.31e-68

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 219.47  E-value: 1.31e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVD 106
Cdd:cd15330    1 IITSLFLGTLILCAIFGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRqqAPEDET---ICQINEEPG 183
Cdd:cd15330   81 VLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAVLISLTWLIGFSISIPPMLGWR--TPEDRSdpdACTISKDPG 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 184 YVLFSALGSFYVPLTIILVMYCRVYVVAkresrglksglktdksdseqvtlrihrknvpaegsgvssaknkthfsvrllk 263
Cdd:cd15330  159 YTIYSTFGAFYIPLILMLVLYGRIFKAA---------------------------------------------------- 186
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755547671 264 fSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFF-PNFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15330  187 -ARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCeSTCHMPELLGAIINWLGYSNSLLNPIIYAYFNKDFQSAF 260
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
28-337 1.69e-68

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 220.55  E-value: 1.69e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  28 LLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDV 107
Cdd:cd15959    2 LAGALLSLAILVIVGGNLLVIVAIAKTPRLQTMTNVFVTSLACADLVMGLLVVPPGATILLTGHWPLGTTVCELWTSVDV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 108 LCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFG--WRQQAPEDETICQIN------ 179
Cdd:cd15959   82 LCVTASIETLCAIAVDRYLAITNPLRYEALVTKRRARTAVCLVWAISAAISFLPIMNqwWRDGADEEAQRCYDNprccdf 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 180 -EEPGYVLFSALGSFYVPLTIILVMYCRVYVVAKRESRGLKSGLktdksdseqvtLRIHRKNVPAEGSGVSSAKNKThfs 258
Cdd:cd15959  162 vTNMPYAIVSSTVSFYVPLLVMIFVYVRVFVVATRQVRLIRKDK-----------VRFPPEESPPAESRPACGRRPS--- 227
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755547671 259 vRLLKFsREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKpPETVFKIVFWLGYLNSCINPIIYpCSSQEFKKAF 337
Cdd:cd15959  228 -RLLAI-KEHKALKTLGIIMGTFTLCWLPFFVANIIKVFCRSLV-PDPAFLFLNWLGYANSAFNPIIY-CRSPDFRSAF 302
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
36-337 3.32e-68

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 218.64  E-value: 3.32e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  36 LIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIM 115
Cdd:cd15321   16 LILFTIFGNVLVIIAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELMGYWYFRKTWCEIYLALDVLFCTSSIV 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 116 GLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQAPEDETI--CQINEEPGYVLFSALGSF 193
Cdd:cd15321   96 HLCAISLDRYWSVSRAIEYNSKRTPRRIKCIILIVWLIAAVISLPPLIYKGKQKDEQGGLpqCKLNEEAWYILSSSIGSF 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 194 YVPLTIILVMYCRVYVVAKresrglksglktdksdseqvtlrihrknvpaegsgvssaknkthfsvrllkfSREKKAAKT 273
Cdd:cd15321  176 FAPCLIMILVYLRIYLIAK----------------------------------------------------NREKRFTFV 203
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755547671 274 LGIVVGCFVLCWLPFFLVMPIGSFFPNF-KPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15321  204 LAVVIGVFVLCWFPFFFSYSLGAICPELcKVPHSLFQFFFWIGYCNSSLNPVIYTIFNQDFRRAF 268
7tmA_Beta2_AR cd15957
beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...
27-337 1.09e-66

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.


Pssm-ID: 341355 [Multi-domain]  Cd Length: 301  Bit Score: 215.88  E-value: 1.09e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVD 106
Cdd:cd15957    1 VGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILLKTWTFGNFWCEFWTSID 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGP--LFGWRQQAPE------DETICQI 178
Cdd:cd15957   81 VLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPiqMHWYRATHQEaincyaEETCCDF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 179 NEEPGYVLFSALGSFYVPLTIILVMYCRVYVVAKRESRglksglKTDKSDSeqvtlRIHRKNVPAEGSGVSSAKNKthfs 258
Cdd:cd15957  161 FTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQ------KIDKSEG-----RFHNQNIDQNGSGGGGGNRR---- 225
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755547671 259 vRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPEtVFKIVFWLGYLNSCINPIIYpCSSQEFKKAF 337
Cdd:cd15957  226 -RSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKE-VYILLNWIGYVNSGFNPLIY-CRSPDFRIAF 301
7tmA_Beta1_AR cd15958
beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...
29-337 9.48e-65

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320624 [Multi-domain]  Cd Length: 298  Bit Score: 210.91  E-value: 9.48e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  29 LGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVL 108
Cdd:cd15958    3 MSLLMALIVLLIVAGNVLVIVAIGRTQRLQTLTNLFITSLACADLVMGLLVVPFGATLVVRGRWLYGSFFCELWTSVDVL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 109 CCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGvRALLC-VWALSLVISIGPLF--GWRQQAP------EDETICQIN 179
Cdd:cd15958   83 CVTASIETLCVIAIDRYLAITSPFRYQSLLTRARA-KGIVCtVWAISALVSFLPIMmhWWRDEDDqalkcyEDPGCCDFV 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 180 EEPGYVLFSALGSFYVPLTIILVMYCRVYVVAKRESRglksglKTDKSDSeqvtlrihRKNVPAEGSGVSSAKNKTHFSV 259
Cdd:cd15958  162 TNRAYAIASSIISFYIPLLIMIFVYLRVYREAKKQIK------KIDKCEG--------RFHNTLTGLGRKCKRRPSRILA 227
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755547671 260 rllkfSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKpPETVFKIVFWLGYLNSCINPIIYpCSSQEFKKAF 337
Cdd:cd15958  228 -----LREQKALKTLGIIMGVFTLCWLPFFLVNVVNVFNRELV-PDWLFVFFNWLGYANSAFNPIIY-CRSPDFRKAF 298
7tmA_D1A_dopamine_R cd15320
D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
27-337 1.71e-64

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320443 [Multi-domain]  Cd Length: 319  Bit Score: 211.02  E-value: 1.71e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHS-VTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGrVFCNIWAAV 105
Cdd:cd15320    2 VLTGCFLSVLILSTLLGNTLVCAAVIRFRHLRSkVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFG-SFCNIWVAF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 106 DVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPL-FGWRQQAP----------EDET 174
Cdd:cd15320   81 DIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKVAFIMISVAWTLSVLISFIPVqLNWHKAKPtsfldlnaslRDLT 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 175 I--CQINEEPGYVLFSALGSFYVPLTIILVMYCRVYVVAKRESRGLksglktdkSDSEQVTlrIHRKNVPAEGSGVSSAK 252
Cdd:cd15320  161 MdnCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQKQIRRI--------SALERAA--VHAKNCQNSTGNRGSGD 230
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 253 NKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFF-PNFKPP----ETVFKIVFWLGYLNSCINPIIYP 327
Cdd:cd15320  231 CQQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCkPTSTEPfcisSTTFDVFVWFGWANSSLNPIIYA 310
                        330
                 ....*....|
gi 755547671 328 CSSqEFKKAF 337
Cdd:cd15320  311 FNA-DFRKAF 319
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
27-337 2.50e-64

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 208.50  E-value: 2.50e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVD 106
Cdd:cd15333    5 ISLAVLLALITLATTLSNAFVIATIYLTRKLHTPANYLIASLAVTDLLVSILVMPISIVYTVTGTWTLGQVVCDIWLSSD 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFgWRQ-QAPEDETICQIN-EEPGY 184
Cdd:cd15333   85 ITCCTASILHLCVIALDRYWAITDAVEYSKKRTPKRAAVMIALVWVISISISLPPFF-WRQaKAEEEVSECVVNtDHILY 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 185 VLFSALGSFYVPLTIILVMYCRVYVVAKresrglksglktdksdseqvtlrihrknvpaegsgvssaknkthfsvrllkf 264
Cdd:cd15333  164 TVYSTVGAFYIPTLLLIALYGRIYVEAR---------------------------------------------------- 191
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755547671 265 SREKKAAKTLGIVVGCFVLCWLPFF---LVMPIGSFFPNFKPpeTVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15333  192 ARERKATKTLGIILGAFIVCWLPFFiisLVLPICKDACWFHL--AIFDFFTWLGYLNSLINPIIYTMSNEDFKQAF 265
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
29-337 4.71e-64

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 207.87  E-value: 4.71e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  29 LGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVL 108
Cdd:cd15323    3 LAAVVGFLIVFTIVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMGYWYFGQVWCNIYLALDVL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 109 CCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQaPEDET--ICQINEEPGYVL 186
Cdd:cd15323   83 FCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKAIIVTVWLISAVISFPPLISMYRD-PEGDVypQCKLNDETWYIL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 187 FSALGSFYVPLTIILVMYCRVYVVAKresrglksglktdksdseqvtlrihrknvpaegsgvssaknkthfsvrllkfSR 266
Cdd:cd15323  162 SSCIGSFFAPCLIMILVYIRIYRVAK----------------------------------------------------AR 189
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755547671 267 EKKAAKTLGIVVGCFVLCWLPFFLVMPI-GSFFPNFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15323  190 EKRFTFVLAVVMGVFVVCWFPFFFSYSLyGICREACEVPEPLFKFFFWIGYCNSSLNPVIYTIFNQDFRRSF 261
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
27-337 9.41e-63

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 205.37  E-value: 9.41e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIfgVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVD 106
Cdd:cd15317    3 IYIVLVLAMLIT--VSGNLVVIISISHFKQLHSPTNMLVLSLATADFLLGLCVMPFSMIRTVETCWYFGDLFCKFHTGLD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQAPEDETI--------CQI 178
Cdd:cd15317   81 LLLCTTSIFHLCFIAIDRYYAVCDPLRYPSKITVQVAWRFIAIGWLVPGIYTFGLIYTGANDEGLEEYSseiscvggCQL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 179 NEEPGYVLFSALgSFYVPLTIILVMYCRVYVVAKRESRGLKSglktdksdseqvtlrihrknvpAEGSGVSSAKNKTHFS 258
Cdd:cd15317  161 LFNKIWVLLDFL-TFFIPCLIMIGLYAKIFLVARRQARKIQN----------------------MEDKFRSSEENSSKAS 217
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755547671 259 VRllkfsREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFpNFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15317  218 AS-----RERKAAKTLAIVMGIFLFCWLPYFIDTIVDEYS-NFITPAIVFDAVIWLGYFNSAFNPFIYAFFYPWFRKAF 290
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
31-337 2.65e-62

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 204.12  E-value: 2.65e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  31 VILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCC 110
Cdd:cd15312    5 LFMAGAILLTVFGNLMVIISISHFKQLHSPTNFLILSLAITDFLLGFLVMPYSMVRSVESCWYFGDLFCKIHSSLDMMLS 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 111 TASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQAPEDETICQI----------NE 180
Cdd:cd15312   85 TTSIFHLCFIAVDRYYAVCDPLHYRTKITTPVIKVFLVISWSVPCLFAFGVVFSEVNLEGIEDYVALVsctgscvlifNK 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 181 EPGYVLFSAlgSFYVPLTIILVMYCRVYVVAKRESRGLKSGLKTDKSDSeqvtlrihrknvpaegsgvssaKNKthfsvr 260
Cdd:cd15312  165 LWGVIASLI--AFFIPGTVMIGIYIKIFFVARKHAKVINNRPSVTKGDS----------------------KNK------ 214
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755547671 261 lLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFpNFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15312  215 -LSKKKERKAAKTLSIVMGVFLLCWLPFFVATLIDPFL-NFSTPVDLFDALVWLGYFNSTCNPLIYGFFYPWFQKAF 289
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
36-337 1.02e-61

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 201.77  E-value: 1.02e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  36 LIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILG-YWAFGRVFCNIWAAVDVLCCTASI 114
Cdd:cd15052   10 LVIATIGGNILVCLAISLEKRLQNVTNYFLMSLAIADLLVGLLVMPLSILTELFGgVWPLPLVLCLLWVTLDVLFCTASI 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 115 MGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISiGPLFGWRQQAPED---ETICQINeEPGYVLFSALG 191
Cdd:cd15052   90 MHLCTISLDRYMAIRYPLRTRRNKSRTTVFLKIAIVWLISIGIS-SPIPVLGIIDTTNvlnNGTCVLF-NPNFVIYGSIV 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 192 SFYVPLTIILVMYCrvyvvakresrglksglktdksdseqvtlrihrknvpaegsgvssaknkthFSVRLLkfSREKKAA 271
Cdd:cd15052  168 AFFIPLLIMVVTYA---------------------------------------------------LTIRLL--SNEQKAS 194
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755547671 272 KTLGIVVGCFVLCWLPFFL--VMPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15052  195 KVLGIVFAVFVICWCPFFItnILTGLCEECNCRISPWLLSVFVWLGYVSSTINPIIYTIFNKTFRRAF 262
7tmA_D1B_dopamine_R cd15319
D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
27-337 1.36e-60

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320442 [Multi-domain]  Cd Length: 317  Bit Score: 200.57  E-value: 1.36e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHS-VTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGrVFCNIWAAV 105
Cdd:cd15319    1 VVTGCLLSLLILWTLLGNILVCAAVVRFRHLRSkVTNIFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFG-AFCDVWVAF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 106 DVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPL-FGWRQQAPEDETICQINEEPG- 183
Cdd:cd15319   80 DIMCSTASILNLCVISVDRYWAISSPFRYERKMTQRVALVMISVAWTLSVLISFIPVqLNWHKDSGDDWVGLHNSSISRq 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 184 ------------YVLFSALGSFYVPLTIILVMYCRVYVVAKRESRGLKSglktdksdseqvtlrIHRKNVPAEGSGVSSA 251
Cdd:cd15319  160 veencdsslnrtYAISSSLISFYIPVAIMIVTYTRIYRIAQIQIRRISS---------------LERAAEHAQSCRSNRI 224
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 252 KNKTHFSVRlLKFSREKKAAKTLGIVVGCFVLCWLPFFLV---MPIGSFFPNFKP------PETVFKIVFWLGYLNSCIN 322
Cdd:cd15319  225 DCHHHTSLR-TSIKKETKVLKTLSVIMGVFVCCWLPFFILncmVPFCDRPPADPDaglpcvSETTFDVFVWFGWANSSLN 303
                        330
                 ....*....|....*
gi 755547671 323 PIIYPCSSqEFKKAF 337
Cdd:cd15319  304 PIIYAFNA-DFRKVF 317
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
29-337 5.77e-60

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 197.09  E-value: 5.77e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  29 LGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVL 108
Cdd:cd15322    3 LIILVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 109 CCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQAPEDET-ICQINEEPGYVLF 187
Cdd:cd15322   83 FCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKKSGQPEGpICKINDEKWYIIS 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 188 SALGSFYVPLTIILVMYCRVYVVAKresrglksglktdksdseqvtlrihrknvpaegsgvssaknkthfsvrllkfSRE 267
Cdd:cd15322  163 SCIGSFFAPCLIMVLVYIRIYQIAK----------------------------------------------------NRE 190
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 268 KKAAKTLGIVVGCFVLCWLPFFLVMPIGSfFPNFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15322  191 KRFTFVLAVVIGVFVICWFPFFFTYTLTA-VCDCSVPETLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAF 259
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
27-337 7.30e-60

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 198.10  E-value: 7.30e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVD 106
Cdd:cd15056    1 VVLSTFLSLVILLTILGNLLVIVAVCTDRQLRKKTNYFVVSLAVADLLVAVLVMPFGAIELVNNRWIYGETFCLVRTSLD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCvWALSLVISIGP-LFGWRQQAPEDETICQINEEPGYV 185
Cdd:cd15056   81 VLLTTASIMHLCCIALDRYYAICCQPLVYKMTPLRVAVMLGGC-WVIPTFISFLPiMQGWNHIGIEDLIAFNCASGSTSC 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 186 LF---------SALGSFYVPLTIILVMYCRVYVVAKRESRGLKSGLKtdksdseqvtlrihrknvpAEGSGVSSAKNKTH 256
Cdd:cd15056  160 VFmvnkpfaiiCSTVAFYIPALLMVLAYYRIYVAAREQAHQIRSLQR-------------------AGSSNHEADQHRNS 220
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 257 fsvrllKFSREKKAAKTLGIVVGCFVLCWLPFFlVMPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKA 336
Cdd:cd15056  221 ------RMRTETKAAKTLGIIMGCFCVCWAPFF-VTNIVDPFIGYRVPYLLWTAFLWLGYINSGLNPFLYAFFNKSFRRA 293

                 .
gi 755547671 337 F 337
Cdd:cd15056  294 F 294
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
27-337 1.34e-59

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 196.00  E-value: 1.34e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVD 106
Cdd:cd15049    1 VLICIATGSLSLVTVGGNILVILSFRVNRQLRTVNNYFLLSLACADLIIGLVSMNLYTVYLVMGYWPLGPLLCDLWLALD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGW-----RQQAPEDETICQINEE 181
Cdd:cd15049   81 YVASNASVMNLLLISFDRYFSVTRPLTYRAKRTPKRAILMIALAWVISFVLWAPAILGWqyfvgERTVPDGQCYIQFLDD 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 182 PGYVLFSALGSFYVPLTIILVMYCRVYvvakRESrglksglktdksdseqvtlrihrknvpaegsgvssaknkthfsvrl 261
Cdd:cd15049  161 PAITFGTAIAAFYLPVLVMTILYWRIY----RET---------------------------------------------- 190
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755547671 262 lkfSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKpPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15049  191 ---ARERKAARTLSAILLAFIITWTPYNILVLVSTFCAKCI-PDTLWSFGYWLCYINSTINPFCYALCNKTFRKTF 262
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
36-337 3.41e-58

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 192.49  E-value: 3.41e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  36 LIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILG-YWAFGRVFCNIWAAVDVLCCTASI 114
Cdd:cd15310   10 LILAIVFGNVLVCMAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGgVWNFSRICCDVFVTLDVMMCTASI 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 115 MGLCIISIDRYIGVSYPLRYPTIVTQ---RRGVRALLCVWALSLVISIGPLFGWrqQAPEDETICQINeEPGYVLFSALG 191
Cdd:cd15310   90 LNLCAISIDRYTAVVMPVHYQHGTGQsscRRVSLMITAVWVLAFAVSCPLLFGF--NTTGDPTVCSIS-NPDFVIYSSVV 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 192 SFYVPLTIILVMYCRVYVVakresrglksglktdksdseqvtlrihrknvpaegsgvssaknkthfsvrllkFSREKKAA 271
Cdd:cd15310  167 SFYLPFGVTLLVYVRIYVV-----------------------------------------------------LLREKKAT 193
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755547671 272 KTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15310  194 QMLAIVLGAFIVCWLPFFLTHILNTHCQACHVPPELYSATTWLGYVNSALNPVIYTTFNIEFRRAF 259
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
27-338 3.05e-57

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 189.77  E-value: 3.05e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVD 106
Cdd:cd15334    1 ILISLTLSILALMTTAINSLVITAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIMYIVKETWIMGQVVCDIWLSVD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFgWRQQAPEDETICQI-NEEPGYV 185
Cdd:cd15334   81 ITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAGIMIAVVWIISIFISMPPLF-WRHQTTSREDECIIkHDHIVFT 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 186 LFSALGSFYVPLTIILVMYCRVYVVAkresrglksglktdksdseqvtlrihrknvpaegsgvssaknkthfsvrllkfS 265
Cdd:cd15334  160 IYSTFGAFYIPLALILILYYKIYRAA-----------------------------------------------------T 186
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755547671 266 REKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQ 338
Cdd:cd15334  187 RERKAATTLGLILGAFVICWLPFFVKEVIVNTCDSCYISEEMSNFLTWLGYINSLINPLIYTIFNEDFKKAFQ 259
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
27-337 3.39e-57

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 190.98  E-value: 3.39e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVD 106
Cdd:cd15048    1 IVLAVLISVLILVTVIGNLLVILAFIKDKKLRTVSNFFLLNLAVADFLVGLVSMPFYIPYTLTGKWPFGKVFCKAWLVVD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVIsIGPL-FGW---RQQAPEDETICQIN--E 180
Cdd:cd15048   81 YTLCTASALTIVLISLDRYLSVTKAVKYRAKQTKRRTVLLMALVWILAFLL-YGPAiIGWdlwTGYSIVPTGDCEVEffD 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 181 EPGYVLFSALGSFYVPLTIILVMYCRVYVVAKRESRglksglktdksdseqvtlRIHRKNVPAEGSGVSSAKNKThfSVR 260
Cdd:cd15048  160 HFYFTFITSVLEFFIPFISVSFFNLLIYLNIRKRSR------------------RRPLRSVPILPASQNPSRARS--QRE 219
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755547671 261 LLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15048  220 QVKLRRDRKAAKSLAILVLVFLICWAPYTILTIIRSFCSGSCVDSYLYEFTFWLLWTNSAINPFLYAACHPRFRKAF 296
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
27-337 8.11e-57

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 188.79  E-value: 8.11e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVD 106
Cdd:cd15050    1 APLGIALSTISLITVILNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVGAVVMPLNIVYLLESKWILGRPVCLFWLSMD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIgPLFGWRQQA-------PEDETICQIN 179
Cdd:cd15050   81 YVASTASIFSLFILCIDRYRSVQQPLKYLKYRTKTRASLMISGAWLLSFLWVI-PILGWHHFArggervvLEDKCETDFH 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 180 EEPGYVLFSALGSFYVPLTIILVMYCRVYVvakresrglksglktdksdseqvtlrihrknvpaegsgvssaknkthfsv 259
Cdd:cd15050  160 DVTWFKVLTAILNFYIPSLLMLWFYAKIFK-------------------------------------------------- 189
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755547671 260 rllKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKpPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15050  190 ---AVNRERKAAKQLGFIMAAFILCWIPYFILFMVIAFCKNCC-NENLHMFTIWLGYINSTLNPFIYPLCNENFKKTF 263
7tmA_5-HT5 cd15328
serotonin receptor subtype 5, member of the class A family of seven-transmembrane G ...
27-337 1.50e-56

serotonin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; 5-HT5 receptor, one of 14 mammalian 5-HT receptors, is activated by the neurotransmitter and peripheral signal mediator serotonin (also known as 5-hydroxytryptamine or 5-HT). The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/0) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320451 [Multi-domain]  Cd Length: 259  Bit Score: 188.24  E-value: 1.50e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGY-WAFGRVFCNIWAAV 105
Cdd:cd15328    1 VLVLTLLAMLVVATFLWNLLVLVTILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRrWQLGRSLCQVWISF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 106 DVLCCTASIMGLCIISIDRYIGVSYPLRYpTIVTQRRGVRALLCV-WALSLVISIGPL-FGWRQQAPEDETICQINEEPG 183
Cdd:cd15328   81 DVLCCTASIWNVTAIALDRYWSITRHLEY-TLRTRRRISNVMIALtWALSAVISLAPLlFGWGETYSEDSEECQVSQEPS 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 184 YVLFSALGSFYVPLTIILVMYCRVYVVAKresrglksglktdksdseqvtlrihrknvpaegsgvssaknkthfsvrllk 263
Cdd:cd15328  160 YTVFSTFGAFYLPLCVVLFVYWKIYKAAQ--------------------------------------------------- 188
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755547671 264 fsREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPetVFKIVF-WLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15328  189 --KEKRAALMVGILIGVFVLCWIPFFLTELISPLCSCDIPP--IWKSIFlWLGYSNSFFNPLIYTAFNKNYNNAF 259
7tmA_alpha-2D_AR cd15324
alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
27-337 4.75e-55

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320447 [Multi-domain]  Cd Length: 256  Bit Score: 184.30  E-value: 4.75e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVD 106
Cdd:cd15324    1 ALIVLVVVVIILVTIVGNVLVVVAVFTSRALRAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGSTWCAFYLALD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFgwrqQAPEDETICQINEEPGYVL 186
Cdd:cd15324   81 VLFCTSSIVHLCAISLDRYWSVTKAVSYNLKRTPKRIKRMIAVVWVISAVISFPPLL----MTKHDEWECLLNDETWYIL 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 187 FSALGSFYVPLTIILVMYCRVYVVAKResrglksglktdksdseqvtlrihrknvpaegsgvssaknkthfsvrllkfsR 266
Cdd:cd15324  157 SSCTVSFFAPGLIMILVYCKIYRVAKM----------------------------------------------------R 184
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755547671 267 EKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFF-PNFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15324  185 EKRFTFVLAVVMGVFVLCWFPFFFTYSLHAVCrKRCGIPDALFNLFFWIGYCNSSVNPIIYTIFNRDFRKAF 256
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
41-337 1.55e-54

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 183.61  E-value: 1.55e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  41 VLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFsAIFEILGYWAfGRVFCNIWAAVDVLCCTASIMGLCII 120
Cdd:cd14968   15 VLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIPL-AILISLGLPT-NFHGCLFMACLVLVLTQSSIFSLLAI 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 121 SIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQAPEDETI------CQINEEPG---YVLFSALG 191
Cdd:cd14968   93 AIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLSFLVGLTPMFGWNNGAPLESGCgeggiqCLFEEVIPmdyMVYFNFFA 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 192 SFYVPLTIILVMYCRVYVVAKRESrglksglktdksdseqvtlrihRKNVPAEGSGVSSAknkthfsvrllKFSREKKAA 271
Cdd:cd14968  173 CVLVPLLIMLVIYLRIFRVIRKQL----------------------RQIESLLRSRRSRS-----------TLQKEVKAA 219
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755547671 272 KTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd14968  220 KSLAIILFLFALCWLPLHIINCITLFCPECKVPKILTYIAILLSHANSAVNPIVYAYRIRKFRQTF 285
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
27-337 4.78e-54

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 181.66  E-value: 4.78e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVD 106
Cdd:cd15335    1 MLIVLTLALITILTTVLNSAVIAAICTTKKLHQPANYLICSLAVTDFLVAVLVMPLSITYIVMDTWTLGYFICEIWLSVD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFgWRQQ---APEDETICQiNEEPG 183
Cdd:cd15335   81 MTCCTCSILHLCVIALDRYWAITDAIEYARKRTAKRAGLMILTVWTISIFISIPPLF-WRNHhdaNIPSQCIIQ-HDHVI 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 184 YVLFSALGSFYVPLTIILVMYCRVYVVAkresrglksglktdksdseqvtlrihrknvpaegsgvssaknkthfsvrllk 263
Cdd:cd15335  159 YTIYSTFGAFYIPLTLILILYYRIYHAA---------------------------------------------------- 186
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755547671 264 fSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPEtVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15335  187 -SRERKAARILGLILGAFILSWLPFFIKELIVGLSVMTVSPE-VADFLTWLGYVNSLVNPLLYTSFNEDFKLAF 258
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
26-337 1.39e-52

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 177.72  E-value: 1.39e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  26 AILLGVILGGLIIfgvLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILG-YWAFGRVFCNIWAA 104
Cdd:cd15308    3 ALVGGVLLILAII---AGNVLVCLSVCTERALKTTTNYFIVSLAVADLLLALLVLPLYVYSEFQGgVWTLSPVLCDALMT 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 105 VDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQAPEDETICQInEEPGY 184
Cdd:cd15308   80 MDVMLCTASIFNLCAISVDRFIAVSVPLNYNRRQGSVRQLLLISATWILSFAVASPVIFGLNNVPNRDPAVCKL-EDNNY 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 185 VLFSALGSFYVPLTIILVMYCRVYvvakresRGLksglktdksdseqvtlrihrknvpaegsgvssaknkthfsvrllkf 264
Cdd:cd15308  159 VVYSSVCSFFIPCPVMLVLYCAMF-------RGL---------------------------------------------- 185
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755547671 265 SREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15308  186 GRERKAMRVLPVVVGAFLFCWTPFFVVHITRALCESCSIPPQLISIVTWLGYVNSALNPVIYTVFNAEFRNVF 258
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
26-336 9.15e-52

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 176.20  E-value: 9.15e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  26 AILLGVILGGLIIfgVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAV 105
Cdd:cd15318    2 VIYLACAIGMLII--VLGNLFVVVTVSHFKALHTPTNFLLLSLALADMLLGLTVLPFSTIRSVESCWYFGDSFCRLHTCL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 106 DVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFG---------WRQQAPEDETiC 176
Cdd:cd15318   80 DTLFCLTSIFHLCFISIDRHCAICDPLLYPSKFTIRVACIFIAAGWLVPTVYTSVFLYTkaveeglaeLLTSVPCVGS-C 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 177 QI--NEEPGYVLFSAlgsFYVPLTIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEqvtlrihrknvpaegsgvssaknk 254
Cdd:cd15318  159 QLlyNKLWGWLNFPV---FFIPCLIMIGLYVKIFIVAKRQARAIASLLSDTNGASK------------------------ 211
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 255 thfsvrllkfsREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFpNFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFK 334
Cdd:cd15318  212 -----------RERKAAKTLGIAVGVYLLCWLPFTIDTMVDSLL-NFITPPLLFDIIIWFAYFNSACNPLIYVFSYPWFR 279

                 ..
gi 755547671 335 KA 336
Cdd:cd15318  280 KA 281
7tmA_TAAR6_8_9 cd15316
trace amine-associated receptors 6, 8, and 9, member of the class A family of ...
27-336 2.22e-51

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320439 [Multi-domain]  Cd Length: 290  Bit Score: 175.43  E-value: 2.22e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVD 106
Cdd:cd15316    1 VILYIVLGFGAVLAVFGNLLVMISILHFKQLHSPTNFLIASLACADFLVGVTVMPFSTVRSVESCWYFGESFCTFHTCCD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQAPEDETI--------CQI 178
Cdd:cd15316   81 VSFCYASLFHLCFISVDRYIAVTDPLVYPTKFTVSVSGICISVSWIFSLTYSFSVFYTGVNDDGLEELVnalncvggCQI 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 179 NEEPGYVLFSALgSFYVPLTIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRknvpaegsgvssaknkthfs 258
Cdd:cd15316  161 ILNQNWVLVDFL-LFFIPTFAMIILYGKIFLVAKQQARKIEMTSSKAESSSESYKDRVAR-------------------- 219
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755547671 259 vrllkfsREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFpNFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKA 336
Cdd:cd15316  220 -------RERKAAKTLGITVIAFLVSWLPYLIDVLIDAFM-NFITPPYIYEICCWCAYYNSAMNPLIYALFYPWFRKA 289
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
27-337 9.00e-51

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 173.94  E-value: 9.00e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVD 106
Cdd:cd14993    1 IVLIVLYVVVFLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPLTLLENVYRPWVFGEVLCKAVPYLQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQAPEDE-------TIC--- 176
Cdd:cd14993   81 GVSVSASVLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWVIAIIIMLPLLVVYELEEIISSepgtitiYICted 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 177 --QINEEPGYVLFSALGSFYVPLTIILVMYCRVyvvakreSRGLKsglktdksdseqvtlriHRKNVPAEGSGVSSAKNK 254
Cdd:cd14993  161 wpSPELRKAYNVALFVVLYVLPLLIISVAYSLI-------GRRLW-----------------RRKPPGDRGSANSTSSRR 216
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 255 THFSvrllkfsrEKKAAKTLGIVVGCFVLCWLPFFLVMpIGSFF--PNFKPPETVFKIVF----WLGYLNSCINPIIYPC 328
Cdd:cd14993  217 ILRS--------KKKVARMLIVVVVLFALSWLPYYVLS-ILLDFgpLSSEESDENFLLILpfaqLLGYSNSAINPIIYCF 287

                 ....*....
gi 755547671 329 SSQEFKKAF 337
Cdd:cd14993  288 MSKKFRRGF 296
7tmA_D2_dopamine_R cd15309
D2 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
30-337 1.96e-49

D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320435 [Multi-domain]  Cd Length: 254  Bit Score: 169.45  E-value: 1.96e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  30 GVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLC 109
Cdd:cd15309    4 AMLLTLLIFVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWRFSRIHCDIFVTLDVMM 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 110 CTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLC-VWALSLVISIGPLFGWRQQapeDETICQInEEPGYVLFS 188
Cdd:cd15309   84 CTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISvVWVLSFAISCPLLFGLNNT---DQNECII-ANPAFVVYS 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 189 ALGSFYVPLTIILVMYCRVYVVakresrglksglktdksdseqvtlrihrknvpaegsgvssaknkthfsvrllkFSREK 268
Cdd:cd15309  160 SIVSFYVPFIVTLLVYVQIYIV-----------------------------------------------------LQKEK 186
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755547671 269 KAAKTLGIVVGCFVLCWLPFFLVMpIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15309  187 KATQMLAIVLGVFIICWLPFFITH-ILNMHCDCNIPPALYSAFTWLGYVNSAVNPIIYTTFNIEFRKAF 254
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
32-344 2.07e-48

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 167.44  E-value: 2.07e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  32 ILGGLIIFGVL-GNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCC 110
Cdd:cd15307    5 LLALVLVLGTAaGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGHFPLSSEHCLTWICLDVLFC 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 111 TASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIgPLFGWRQQAPED---ETICQInEEPGYVLF 187
Cdd:cd15307   85 TASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSL-PLSLMYSKDHASvlvNGTCQI-PDPVYKLV 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 188 SALGSFYVPLTIILVMYC-RVYVVAKRESRglksglktdksdseqvtlriHRKNvpaegsgvssaknkthfsVRLlkfsr 266
Cdd:cd15307  163 GSIVCFYIPLGVMLLTYClTVRLLARQRSR--------------------HGRI------------------IRL----- 199
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 267 EKKAAKTLGIVVGCFVLCWLPFFL--VMPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQ 344
Cdd:cd15307  200 EQKATKVLGVVFFTFVILWSPFFVlnLLPTVCAECEERISHWVFDVVTWLGYASSMVNPIFYTIFNKVFRQAFKKVLLCR 279
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
27-337 1.84e-47

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 164.59  E-value: 1.84e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVD 106
Cdd:cd15054    1 GWVAAFLCLIILLTVAGNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMVGLVVMPPAMLNALYGRWVLARDFCPIWYAFD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPL-FGWRQQA----------PEDETI 175
Cdd:cd15054   81 VMCCSASILNLCVISLDRYLLIISPLRYKLRMTPPRALALILAAWTLAALASFLPIeLGWHELGhertlpnltsGTVEGQ 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 176 CQINEEPGYVLFSALGSFYVPLTIILVMYCRVYVVAKresrglksglktdksdseqvtlrihrknvpaegsgvssaknkt 255
Cdd:cd15054  161 CRLLVSLPYALVASCLTFFLPSGAICFTYCRILLAAR------------------------------------------- 197
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 256 hfsvrllkfsREKKAAKTLGIVVGCFVLCWLPFFlVMPIGSFFPNFKPPEtVFKIVFWLGYLNSCINPIIYPCSSQEFKK 335
Cdd:cd15054  198 ----------KALKASLTLGILLGMFFVTWLPFF-VANVVQAVCDCVSPG-LFDVLTWLGYCNSTMNPIIYPLFMRDFKR 265

                 ..
gi 755547671 336 AF 337
Cdd:cd15054  266 AL 267
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
27-337 2.93e-47

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 164.39  E-value: 2.93e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTvLPFSAIFEILGYWAFGRVFCNIWAAVD 106
Cdd:cd14970    1 IVIPAVYSVVCVVGLTGNSLVIYVILRYSKMKTVTNIYILNLAVADELFLLG-LPFLATSYLLGYWPFGEVMCKIVLSVD 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIG-PLFGWRQQAPEDETICQIN--EEPG 183
Cdd:cd14970   80 AYNMFTSIFCLTVMSVDRYLAVVHPVKSLRFRTPRKAKLVSLCVWALSLVLGLPvIIFARTLQEEGGTISCNLQwpDPPD 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 184 Y-----VLFSALGSFYVPLTIILVMYCRvyvvakresrglksglktdksdseqVTLRIHRKNVPAEGSGVSSAKNKthfs 258
Cdd:cd14970  160 YwgrvfTIYTFVLGFAVPLLVITVCYSL-------------------------IIRRLRSSRNLSTSGAREKRRAR---- 210
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 259 vrllkfsreKKAAKTLGIVVGCFVLCWLPFFlVMPIGSFFPNFKPPET---VFKIVFWLGYLNSCINPIIYPCSSQEFKK 335
Cdd:cd14970  211 ---------RKVTRLVLVVVAVFVVCWLPFH-VFQIVRLLIDPPETLTvvgVFLFCIALSYANSCLNPILYAFLDENFRK 280

                 ..
gi 755547671 336 AF 337
Cdd:cd14970  281 SF 282
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
27-337 1.69e-44

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 157.07  E-value: 1.69e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVD 106
Cdd:cd15096    1 IVVPVIFGLIFIVGLIGNSLVILVVLSNQQMRSTTNILILNLAVADLLFVVFCVPFTATDYVLPTWPFGDVWCKIVQYLV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWR----QQAPEDETICQINEEP 182
Cdd:cd15096   81 YVTAYASVYTLVLMSLDRYLAVVHPITSMSIRTERNTLIAIVGIWIVILVANIPVLFLHGvvsyGFSSEAYSYCTFLTEV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 183 GYVLFSALGSFYV-----PLTIILVMYCRvyvvakresrglksglktdksdseqVTLRIHRKNVPAEGSGVSSAKNKthf 257
Cdd:cd15096  161 GTAAQTFFTSFFLfsyliPLTLICVLYML-------------------------MLRRLRRQKSPGGRRSAESQRGK--- 212
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 258 svrllkfsreKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFfpnFKPPETVFKIVF-----WLGYLNSCINPIIYPCSSQE 332
Cdd:cd15096  213 ----------RRVTRLVVVVVVVFAICWLPIHIILLLKYY---GVLPETVLYVVIqilsnCLAYGNSCVNPILYAFLSQN 279

                 ....*
gi 755547671 333 FKKAF 337
Cdd:cd15096  280 FRKAF 284
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
27-337 3.13e-44

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 155.90  E-value: 3.13e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVD 106
Cdd:cd17790    1 VLIVITTGILSLVTVTGNLLVLISFKVNSELKTVNNYFLLSLACADLIIGAFSMNLYTTYILMGHWALGTVACDLWLALD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWR-----QQAPEDETICQINEE 181
Cdd:cd17790   81 YVASNASVMNLLIISFDRYFSITRPLTYRAKRTPRRAAIMIGLAWLISFVLWAPAILFWQylvgeRTVLAGQCYIQFLSQ 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 182 PGYVLFSALGSFYVPLTIILVMYCRVYvvakRESrglksglktdksdseqvtlrihrknvpaegsgvssaknkthfsvrl 261
Cdd:cd17790  161 PIITFGTAIAAFYLPVTIMIILYWRIY----RET---------------------------------------------- 190
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755547671 262 lkfSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKpPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd17790  191 ---IKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCV-PKTLWELGYWLCYVNSTVNPMCYALCNKSFRDTF 262
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
25-345 1.03e-42

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 152.02  E-value: 1.03e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  25 KAILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAA 104
Cdd:cd15299    2 QVVLIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLS 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 105 VDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGW-----RQQAPEDETICQIN 179
Cdd:cd15299   82 IDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWqyfvgKRTVPPDECFIQFL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 180 EEPGYVLFSALGSFYVPLTIILVMYCRVYvvakRESrglksglktdksdseqvtlrihrknvpaegsgvssaknkthfsv 259
Cdd:cd15299  162 SEPIITFGTAIAAFYLPVTIMTILYWRIY----KET-------------------------------------------- 193
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 260 rllkfSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKpPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQN 339
Cdd:cd15299  194 -----IKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCI-PKTYWNLGYWLCYINSTVNPVCYALCNKTFRTTFKM 267

                 ....*.
gi 755547671 340 VLRIQC 345
Cdd:cd15299  268 LLLCQC 273
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
27-337 1.03e-42

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 151.90  E-value: 1.03e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVD 106
Cdd:cd15301    1 VLIVIVAAVLSLVTVGGNVMVMISFKIDKQLQTISNYFLFSLAVADFAIGVISMPLFTVYTALGYWPLGYEVCDTWLAID 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGW-----RQQAPEDETICQINEE 181
Cdd:cd15301   81 YLASNASVLNLLIISFDRYFSVTRPLTYRARRTTKKAAVMIASAWIISLLLWPPWIYSWpyiegKRTVPAGTCYIQFLET 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 182 PGYVLF-SALGSFYVPLTIILVMYCRVYVVAKRESRglksglktdksdseqvtlrihrknvpaegsgvssaknkthfsvr 260
Cdd:cd15301  161 NPYVTFgTALAAFYVPVTIMCILYWRIWRETKKRQK-------------------------------------------- 196
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755547671 261 llkfSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKP-PETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15301  197 ----KQESKAAKTLSAILLAFIVTWTPYNVLVLIKAFFPCSDTiPTELWDFSYYLCYINSTINPLCYALCNAAFRRTY 270
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
27-337 1.59e-42

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 152.05  E-value: 1.59e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVD 106
Cdd:cd15095    1 WLVPLIFAIIFLVGLAGNSLVIYVVSRHREMRTVTNYYIVNLAVTDLAFLVCCVPFTAALYATPSWVFGDFMCKFVNYMM 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQA---PEDETICQ-----I 178
Cdd:cd15095   81 QVTVQATCLTLTALSVDRYYAIVHPIRSLRFRTPRVAVVVSACIWIVSFLLSIPVAIYYRLEEgywYGPQTYCRevwpsK 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 179 NEEPGYVLFSALGSFYVPLTIILVMYCrvyVVAKRESRGLKSGLKTDKSDSEQVTlrihrknvpaegsgvssaknkthfs 258
Cdd:cd15095  161 AFQKAYMIYTVLLTYVIPLAIIAVCYG---LILRRLWRRSVDGNNQSEQLSERAL------------------------- 212
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 259 vrllkfSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPETVFKIVFW---LGYLNSCINPIIYPCSSQEFKK 335
Cdd:cd15095  213 ------RQKRKVTRMVIVVVVLFAICWLPNHVLNLWQRFDPNFPETYATYALKIAalcLSYANSAVNPFVYAFMGENFRK 286

                 ..
gi 755547671 336 AF 337
Cdd:cd15095  287 YF 288
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
27-337 6.04e-42

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 149.73  E-value: 6.04e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVD 106
Cdd:cd15297    1 VFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWR-----QQAPEDETICQINEE 181
Cdd:cd15297   81 YVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQfivggRTVPEGECYIQFFSN 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 182 PGYVLFSALGSFYVPLTIILVMYCRvyvvakresrglksglktdksdseqvtlrihrknvpaegsgVSSAKnkthfsvrl 261
Cdd:cd15297  161 AAVTFGTAIAAFYLPVIIMTVLYWQ-----------------------------------------ISRAS--------- 190
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755547671 262 lkfSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKpPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15297  191 ---SREKKVTRTILAILLAFIITWTPYNVMVLINTFCASCI-PNTVWTIGYWLCYINSTINPACYALCNATFKKTF 262
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
27-337 1.83e-41

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 148.89  E-value: 1.83e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVD 106
Cdd:cd14969    1 YVLAVYLSLIGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIGVSYPLRYPTIvTQRRGVRALLCVWALSLVISIGPLFGWRQQAPE-DETICQINEEPG-- 183
Cdd:cd14969   81 TFLGLVSISTLAALAFERYLVIVRPLKAFRL-SKRRALILIAFIWLYGLFWALPPLFGWSSYVPEgGGTSCSVDWYSKdp 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 184 ----YVLFSALGSFYVPLTIILVMYCRVYVvakresrglksglktdksdseqvTLRIHRKNVPAEGSGVSSAKNKthfsv 259
Cdd:cd14969  160 nslsYIVSLFVFCFFLPLAIIIFCYYKIYR-----------------------TLRKMSKRAARRKNSAITKRTK----- 211
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755547671 260 rllkfSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd14969  212 -----KAEKKVAKMVLVMIVAFLIAWTPYAVVSLYVSFGGESTIPPLLATIPALFAKSSTIYNPIIYVFMNKQFRRAL 284
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
36-342 1.97e-41

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 148.90  E-value: 1.97e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  36 LIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGY-WAFGRVFCNIWAAVDVLCCTASI 114
Cdd:cd15305   10 IIILTIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPVSLIAILYDYaWPLPRYLCPIWISLDVLFSTASI 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 115 MGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIG-PLFGWRQQAPE-DETICQINEEpGYVLFSALGS 192
Cdd:cd15305   90 MHLCAISLDRYVAIRNPIEHSRFNSRTKAMMKIAAVWTISIGISMPiPVIGLQDDEKVfVNGTCVLNDE-NFVLIGSFVA 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 193 FYVPLTIILVMYC-RVYVVAKRESrglksglktdksdseqvtlrihrknvpaegsgvssaknkthfsvrllkFSREKKAA 271
Cdd:cd15305  169 FFIPLIIMVITYClTIQVLQRQQA------------------------------------------------INNERRAS 200
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755547671 272 KTLGIVVGCFVLCWLPFFLVMPIGSFFP---NFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLR 342
Cdd:cd15305  201 KVLGIVFFLFLIMWCPFFITNILSVLCKeacDQKLMEELLNVFVWVGYVSSGINPLVYTLFNKTYRRAFSNYIR 274
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
36-337 6.38e-41

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 147.00  E-value: 6.38e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  36 LIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGY-WAFGRVFCNIWAAVDVLCCTASI 114
Cdd:cd15304   10 VIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYrWPLPSKLCAVWIYLDVLFSTASI 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 115 MGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIG-PLFGWRQQAPE-DETICQINEEpGYVLFSALGS 192
Cdd:cd15304   90 MHLCAISLDRYIAIRNPIHHSRFNSRTKAFLKIIAVWTISVGISMPiPVFGLQDDSKVfKEGSCLLADE-NFVLIGSFVA 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 193 FYVPLTIILVMYCrvyvvakresrglksglktdksdseqVTLRIHRKNVpaegsgvssaknkthfsvrllkfSREKKAAK 272
Cdd:cd15304  169 FFIPLTIMVITYF--------------------------LTIKSLQQSI-----------------------SNEQKASK 199
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755547671 273 TLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPETV---FKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15304  200 VLGIVFFLFVVMWCPFFITNVMAVICKESCNEVVIgglLNVFVWIGYLSSAVNPLVYTLFNKTYRSAF 267
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
27-337 6.61e-41

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 147.75  E-value: 6.61e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVD 106
Cdd:cd15203    1 IILILLYGLIIVLGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLCLVSLPFTLIYTLTKNWPFGSILCKLVPSLQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIGVSYPLRypTIVTQRRGVRALLCVWALSLVISIgPLF-------GWRQQAPEDETICqIN 179
Cdd:cd15203   81 GVSIFVSTLTLTAIAIDRYQLIVYPTR--PRMSKRHALLIIALIWILSLLLSL-PLAifqelsdVPIEILPYCGYFC-TE 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 180 EEPG------YVLFSALGSFYVPLTIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRihrknvpaegsgvssaKN 253
Cdd:cd15203  157 SWPSsssrliYTISVLVLQFVIPLLIISFCYFRISLKLRKRVKKKRGKRTLSSRRRRSELRR----------------KR 220
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 254 KTHfsvRLLkfsrekkaaktLGIVVgCFVLCWLPFFLVMPIGSFFPNFKPPETVFKIVF----WLGYLNSCINPIIYPCS 329
Cdd:cd15203  221 RTN---RLL-----------IAMVV-VFAVCWLPLNLFNLLRDFEPLPQIDGRHFYLIFlichLIAMSSACVNPLLYGWL 285

                 ....*...
gi 755547671 330 SQEFKKAF 337
Cdd:cd15203  286 NDNFRKEF 293
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
32-337 6.61e-41

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 147.77  E-value: 6.61e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  32 ILGGLIIF--GVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLC 109
Cdd:cd15207    4 IVSYSLIFllCVVGNVLVCLVVAKNPRMRTVTNYFILNLAVSDLLVGVFCMPFTLVDNILTGWPFGDVMCKLSPLVQGVS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 110 CTASIMGLCIISIDRYIGVSYPLRYPtiVTQRRGVRALLCVWALSLVISIgPLFGWRQQAPEDE------TICQ-----I 178
Cdd:cd15207   84 VAASVFTLVAIAVDRYRAVVHPTEPK--LTNRQAFVIIVAIWVLALAIMI-PQALVLEVKEYQFfrgqtvHICVefwpsD 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 179 NEEPGYVLFSALGSFYVPLTIILVMYCRVyvvakresrglksglktdksdseqvTLRIHRKNVPAEGSgvSSAKNKTHFS 258
Cdd:cd15207  161 EYRKAYTTSLFVLCYVAPLLIIAVLYVRI-------------------------GYRLWFKPVPGGGS--ASREAQAAVS 213
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 259 vrllkfSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFfPNFKPPET------VFKIVFWLGYLNSCINPIIYPCSSQE 332
Cdd:cd15207  214 ------KKKVRVIKMLIVVVVLFALSWLPLHTVTMLDDF-GNLSPNQRevlyvyIYPIAHWLAYFNSCVNPIVYGYFNRN 286

                 ....*
gi 755547671 333 FKKAF 337
Cdd:cd15207  287 FRKGF 291
7tmA_mAChR_GAR-2-like cd15302
muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of ...
27-337 1.07e-40

muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320429 [Multi-domain]  Cd Length: 266  Bit Score: 146.43  E-value: 1.07e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILG-YWAFGRVFCNIWAAV 105
Cdd:cd15302    1 ILLALITAILSIITVIGNILVLLSFYVDRNIRQPSNYFIASLAVSDLLIGLESMPFYTVYVLNGdYWPLGWVLCDLWLSV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 106 DVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWR------QQAPEDETICQIN 179
Cdd:cd15302   81 DYTVCLVSIYTVLLITIDRYCSVKIPAKYRNWRTPRKVLLIIAITWIIPALLFFISIFGWQyftgqgRSLPEGECYVQFM 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 180 EEPGYVLFSALGSFYVPLTIILVMYCRVYVVAKresrglksglktdksdseqvtlrihrknvpaegsgvssaknkthfsv 259
Cdd:cd15302  161 TDPYFNMGMYIGYYWTTLIVMLILYAGIYRAAN----------------------------------------------- 193
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755547671 260 rllkfsREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKP-PETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15302  194 ------RARKALRTITFILGAFVICWTPYHILATIYGFCEAPPCvNETLYTISYYLCYMNSPINPFCYALANQQFKKTF 266
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
27-337 2.06e-40

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 146.42  E-value: 2.06e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVD 106
Cdd:cd14992    1 IILGVALVVIILVSVVGNFIVIAALARHKNLRGATNYFIASLAISDLLMALFCTPFNFTYVVSLSWEYGHFLCKIVNYLR 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQA------PEDETICQINE 180
Cdd:cd14992   81 TVSVYASSLTLTAIAFDRYFAIIHPLKPRHRQSYTTTVIIIITIWVVSLLLAIPQLYYATTEVlfsvknQEKIFCCQIPP 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 181 EPG------YVLFSALGSFYVPLTIILVMYCRVYV-VAKRESRGlksglktdKSDSEQVTLRIHRKnvpaegsgvssakn 253
Cdd:cd14992  161 VDNktyekvYFLLIFVVIFVLPLIVMTLAYARISReLWFRKVPG--------FSIKEVERKRLKCK-------------- 218
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 254 kthfsvrllkfsreKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPE---TVFKIVFWLGYLNSCINPIIYPCSS 330
Cdd:cd14992  219 --------------RRVIKMLVCVVVLFVICWLPFHLFFLLRDFFPLIMKEKhtlQVYYFLHWIAMSNSMYNPIIYVTLN 284

                 ....*..
gi 755547671 331 QEFKKAF 337
Cdd:cd14992  285 NNFRKNF 291
7tmA_mAChR_M4 cd15298
muscarinic acetylcholine receptor subtype M4, member of the class A family of ...
27-337 8.92e-40

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341344 [Multi-domain]  Cd Length: 262  Bit Score: 144.01  E-value: 8.92e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVD 106
Cdd:cd15298    1 VFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGW-----RQQAPEDETICQINEE 181
Cdd:cd15298   81 YVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWqfvvgKRTVPDNQCFIQFLSN 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 182 PGYVLFSALGSFYVPLTIILVMYcrvyvvakresrglksglktdksdseqvtlrihrknvpaegsgvssaknkTHFSvrl 261
Cdd:cd15298  161 PAVTFGTAIAAFYLPVVIMTVLY--------------------------------------------------IHIS--- 187
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755547671 262 LKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKpPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15298  188 LASARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCI-PDTVWSIGYWLCYVNSTINPACYALCNATFKKTF 262
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
29-337 1.74e-38

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 140.89  E-value: 1.74e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  29 LGVILGgliIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVdVL 108
Cdd:cd14972    4 VAIVLG---VFIVVENSLVLAAIIKNRRLHKPMYILIANLAAADLLAGIAFVFTFLSVLLVSLTPSPATWLLRKGSL-VL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 109 CCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQAPEDETICQINE--EPGYVL 186
Cdd:cd14972   80 SLLASAYSLLAIAVDRYISIVHGLTYVNNVTNKRVKVLIALVWVWSVLLALLPVLGWNCVLCDQESCSPLGPglPKSYLV 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 187 FsALGSFYVPLTIILVMYCRVYVVAKResrglksglKTDKSDSEQVTLRIHRKnvpaegsgvssaknkthfsvrllkfSR 266
Cdd:cd14972  160 L-ILVFFFIALVIIVFLYVRIFWCLWR---------HANAIAARQEAAVPAQP-------------------------ST 204
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755547671 267 EKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd14972  205 SRKLAKTVVIVLGVFLVCWLPLLILLVLDVLCPSVCDIQAVFYYFLVLALLNSAINPIIYAFRLKEMRRAV 275
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
27-337 4.44e-38

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 140.57  E-value: 4.44e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSaIFEILGY--WAFGRVFCNIWAA 104
Cdd:cd14979    1 VLVTAIYVAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLPVE-LYNFWWQypWAFGDGGCKLYYF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 105 VDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISI--GPLFGWRQQ------APEDETIC 176
Cdd:cd14979   80 LFEACTYATVLTIVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSILCAIpiLFLMGIQYLngplpgPVPDSAVC 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 177 QINEEPGYVL----FSALGSFYVPLTIILVMYCRVyvvakresrGLKsgLKTDKSDSEQVTLRiHRKNVPAEGSGvssak 252
Cdd:cd14979  160 TLVVDRSTFKyvfqVSTFIFFVLPMFVISILYFRI---------GVK--LRSMRNIKKGTRAQ-GTRNVELSLSQ----- 222
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 253 nkthfsvrllkfSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPETVFK-----IVFWLGYLNSCINPIIYP 327
Cdd:cd14979  223 ------------QARRQVVKMLGAVVIAFFVCWLPFHAQRLMFSYASKEDTFLFDFYqylypISGILFYLSSAINPILYN 290
                        330
                 ....*....|
gi 755547671 328 CSSQEFKKAF 337
Cdd:cd14979  291 LMSSRFRVAF 300
7tmA_mAChR_M5 cd15300
muscarinic acetylcholine receptor subtype M5, member of the class A family of ...
41-337 5.87e-38

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320427 [Multi-domain]  Cd Length: 262  Bit Score: 139.01  E-value: 5.87e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  41 VLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMGLCII 120
Cdd:cd15300   15 IVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTSYILMGYWALGSLACDLWLALDYVASNASVMNLLVI 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 121 SIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGW-----RQQAPEDETICQINEEPGYVLFSALGSFYV 195
Cdd:cd15300   95 SFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPPILCWqyfvgKRTVPERECQIQFLSEPTITFGTAIAAFYI 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 196 PLTIILVMYCRVYvvakRESrglksglktdksdseqvtlrihrknvpaegsgvssaknkthfsvrllkfSREKKAAKTLG 275
Cdd:cd15300  175 PVSVMTILYCRIY----KET-------------------------------------------------IKERKAAQTLS 201
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755547671 276 IVVGCFVLCWLPFFLVMPIGSFFPNFKPPeTVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15300  202 AILLAFIITWTPYNIMVLVSTFCSDCIPL-TLWHLGYWLCYVNSTVNPMCYALCNKTFRKTF 262
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
27-337 6.12e-36

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 134.77  E-value: 6.12e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAiFEILGY--WAFGRVFCNIWAA 104
Cdd:cd15134    1 IPITIIYGIIFVTGVVGNLCTCIVIARNRSMHTATNYYLFSLAVSDLLLLILGLPFEL-YTIWQQypWVFGEVFCKLRAF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 105 VDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISI----------GPLFGWRQQAPEDET 174
Cdd:cd15134   80 LSEMSSYASVLTITAFSVERYLAICHPLRSHTMSKLSRAIRIIIAIWIIAFVCALpfaiqtrivyLEYPPTSGEALEESA 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 175 IC----QINEEPGYVLFSALGSFYVPLTIILVMYCRvyvvakresrglksglktdksdseqVTLRIHRKNVPAEGSGVSS 250
Cdd:cd15134  160 FCamlnEIPPITPVFQLSTFLFFIIPMIAIIVLYVL-------------------------IGLQLRRSTLLRRGQRSVS 214
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 251 AKNKTHfsvrllkfSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPP-ETVFKIVFW----LGYLNSCINPII 325
Cdd:cd15134  215 GGRRSS--------QSRRTVLRMLVAVVVAFFICWAPFHAQRLLTVYAKNMTPPyLFINRILFYisgvLYYVSSTVNPIL 286
                        330
                 ....*....|..
gi 755547671 326 YPCSSQEFKKAF 337
Cdd:cd15134  287 YNVMSAKYRQAF 298
7tmA_Histamine_H3R cd15296
histamine receptor subtypes H3R and H3R-like, member of the class A family of ...
27-337 8.13e-36

histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H3R-like, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320423 [Multi-domain]  Cd Length: 271  Bit Score: 133.38  E-value: 8.13e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVD 106
Cdd:cd15296    1 VILAVLMALLVVATVLGNALVILAFVVDSSLRTQGNFFFLNLAISDFLVGGFCIPLYIPYVLTGRWKFGRGLCKLWLVVD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQ-RRGVRALLCVWALSLVISIGPLFGWRQQA-----PEDETICQINE 180
Cdd:cd15296   81 YLLCTASVFNIVLISYDRFLSVTRAVSYRAQKGMtRQAVLKMVLVWVLAFLLYGPAIISWEYIAggsiiPEGECYAEFFY 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 181 EPGYVLFSALGSFYVPLTIILVMYCRVYvvakresrglksglktdksdseqvtLRIHRknvpaegsgvssaknkthfsvR 260
Cdd:cd15296  161 NWYFLMTASTLEFFTPFISVTYFNLSIY-------------------------LNIQK---------------------R 194
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755547671 261 LLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15296  195 RFRLSRDKKVAKSLAIIVCVFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWVNSAINPVLYPLCHMSFRRAF 271
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
27-336 1.28e-35

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 133.61  E-value: 1.28e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVD 106
Cdd:cd15083    1 YVLGIFILIIGLIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGCDMYGFSG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQAPED-ETICQIN---EEP 182
Cdd:cd15083   81 GLFGIMSINTLAAIAVDRYLVITRPMKASVRISHRRALIVIAVVWLYSLLWVLPPLFGWSRYVLEGlLTSCSFDylsRDD 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 183 G---YVLFSALGSFYVPLTIILVMYCRVYVVAKRESRGLKSGLKTdKSDSEQVTLRIHRKnvpaegsgvssaknkthfsv 259
Cdd:cd15083  161 AnrsYVICLLIFGFVLPLLIIIYCYSFIFRAVRRHEKAMKEMAKR-FSKSELSSPKARRQ-------------------- 219
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755547671 260 rllkfsREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKA 336
Cdd:cd15083  220 ------AEVKTAKIALLLVLLFCLAWTPYAVVALIGQFGYLEVLTPLATAIPAAFAKTSAIYNPVIYAFSHPKFRRA 290
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
31-337 1.47e-35

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 132.78  E-value: 1.47e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  31 VILGGLIIF--GVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVL 108
Cdd:cd15001    2 VIIVYVITFvlGLIGNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFCVPLKTAEYFSPTWSLGAFLCKAVAYLQLL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 109 CCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFG-------WRQQAPEDETICQINE- 180
Cdd:cd15001   82 SFICSVLTLTAISIERYYVILHPMKAKSFCTIGRARKVALLIWILSAILASPVLFGqglvryeSENGVTVYHCQKAWPSt 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 181 --EPGYVLFSALGSFYVPLTIILVMYcrvyvvakresrglksglktdksdseqvtLRIHRKNVpaegsgvssaknkthfs 258
Cdd:cd15001  162 lySRLYVVYLAIVIFFIPLIVMTFAY-----------------------------ARDTRKQV----------------- 195
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 259 vrllkfsrekkaAKTLGIVVGCFVLCWLPFFLVMPIGSF-------FPNFKPPETVFKIvfwLGYLNSCINPIIYPCSSQ 331
Cdd:cd15001  196 ------------IKMLISVVVLFAVCWGPLLIDNLLVSFdvistlhTQALKYMRIAFHL---LSYANSCINPIIYAFMSK 260

                 ....*.
gi 755547671 332 EFKKAF 337
Cdd:cd15001  261 NFRSSF 266
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
38-337 1.57e-35

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 133.52  E-value: 1.57e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  38 IFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEIlGYWAfgRVFCNIWAAVDVLCCTAS-IMG 116
Cdd:cd15068   12 VLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITIST-GFCA--ACHGCLFIACFVLVLTQSsIFS 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 117 LCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQAPEDETICQINEEPG------------- 183
Cdd:cd15068   89 LLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEgqvaclfedvvpm 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 184 --YVLFSALGSFYVPLTIILVMYCRVYVVAKRESRGLKSglktdksdseqvtlrihrkNVPAEGSGVSSAKNKTHfsvrl 261
Cdd:cd15068  169 nyMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMES-------------------QPLPGERARSTLQKEVH----- 224
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755547671 262 lkfsrekkAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNF-KPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15068  225 --------AAKSLAIIVGLFALCWLPLHIINCFTFFCPDCsHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTF 293
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
27-337 1.73e-35

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 132.97  E-value: 1.73e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTvLPFSAIFEILGYWAFGRVFCNIWAAVD 106
Cdd:cd15093    1 VLIPCIYAVVCLVGLCGNSLVIYVVLRYAKMKTVTNIYILNLAIADELFMLG-LPFLAASNALRHWPFGSVLCRLVLSVD 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALS-LVISIGPLFGWRQQAPEDETICQIN-EEP-- 182
Cdd:cd15093   80 GINMFTSIFCLTVMSVDRYLAVVHPIKSARWRRPRVAKVVNLAVWVASlLVILPVVVFAGTRENQDGSSACNMQwPEPaa 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 183 ----GYVLFSALGSFYVPLTIILVmyCRVYVVAKRESRGLKSGLKTDKSDseqvtlrihrknvpaegsgvssaknkthfs 258
Cdd:cd15093  160 awsaGFIIYTFVLGFLLPLLIICL--CYLLIVIKVKSAGLRAGWQQRKRS------------------------------ 207
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 259 vrllkfsrEKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPE--TVFKIVFWLGYLNSCINPIIYPCSSQEFKKA 336
Cdd:cd15093  208 --------ERKVTRMVVMVVVVFVICWLPFYVLQLVNVFVQLPETPAlvGVYHFVVILSYANSCANPILYGFLSDNFKKS 279

                 .
gi 755547671 337 F 337
Cdd:cd15093  280 F 280
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
27-337 3.49e-35

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 132.16  E-value: 3.49e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHL--HSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFC---NI 101
Cdd:cd15098    1 VIVPVVFGLIFCLGVLGNSLVITVLARVKPGkrRSTTNVFILNLSIADLFFLLFCVPFQATIYSLPEWVFGAFMCkfvHY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 102 WAAVDVLcctASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQ---QAPEDETIC-- 176
Cdd:cd15098   81 FFTVSML---VSIFTLVAMSVDRYIAVVHSRTSSSLRTRRNALLGVLVIWVLSLAMASPVAVHQDLvhhWTASNQTFCwe 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 177 ---QINEEPGYVLFSALGSFYVPLTIILVMYCRVyvvakresrgLKSGLKTDKSDSEQvtlrihrknvpAEGSgvssakn 253
Cdd:cd15098  158 nwpEKQQKPVYVVCTFVFGYLLPLLLITFCYAKV----------LNHLHKKLKNMSKK-----------SERS------- 209
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 254 kthfsvrllkfsrEKKAAKTLGIVVGCFVLCWLPFFLVMPIGSF--FPnFKPPETVFKIV-FWLGYLNSCINPIIYPCSS 330
Cdd:cd15098  210 -------------KKKTAQTVLVVVVVFGISWLPHHIIHLWVEFgdFP-LTQASFVLRITaHCLAYANSCVNPIIYAFLS 275

                 ....*..
gi 755547671 331 QEFKKAF 337
Cdd:cd15098  276 ENFRKAY 282
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
30-337 1.40e-34

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 130.97  E-value: 1.40e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  30 GVILGGLIIF--GVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDV 107
Cdd:cd15208    2 VLIALYILVFivGLVGNVLVCFAVWRNHHMRTVTNYFIVNLSLADFLVIIICLPATLLVDVTETWFFGQVLCKIIPYLQT 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 108 LCCTASIMGLCIISIDRYIGVSYPLRYPTivTQRRGVRALLCVWALSLVISI--------GPLFGWRQQAPE----DETI 175
Cdd:cd15208   82 VSVSVSVLTLSCIALDRWYAICHPLMFKS--TAKRARVSILIIWIVSLLIMIpqaivmecSRVVPLANKTILltvcDERW 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 176 CQINEEPGYVLFSALGSFYVPLTIILVMYCRVYVVakresrglksgLKTDKSDSEQVtlRIHRKNVPAEGSGVSSAKNKT 255
Cdd:cd15208  160 SDSIYQKVYHICFFLVTYLLPLCLMILAYFQIFRK-----------LWCRQIPGTSS--VVQRKWNKPRKSAVAAEEKQL 226
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 256 HfsvrllkfSReKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFK-PPETV---FKIVFWLGYLNSCINPIIYPCSSQ 331
Cdd:cd15208  227 R--------SR-RKTAKMLIVVVIMFAICYLPVHLLNILRYVFGLFTvDRETIyawFLFSHWLVYANSAINPIIYNFMSG 297

                 ....*.
gi 755547671 332 EFKKAF 337
Cdd:cd15208  298 KFREEF 303
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
27-337 2.00e-34

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 130.11  E-value: 2.00e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVD 106
Cdd:cd15390    1 VLWSIVFVVMVLVAIGGNLIVIWIVLAHKRMRTVTNYFLVNLAVADLLISAFNTVFNFTYLLYNDWPFGLFYCKFSNFVA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIGVSYPLRYPTivTQRRGVRALLCVWALSLVISIGPLFGWRQ-----QAPEDETICQINEE 181
Cdd:cd15390   81 ITTVAASVFTLMAISIDRYIAIVHPLRPRL--SRRTTKIAIAVIWLASFLLALPQLLYSTTetyyyYTGSERTVCFIAWP 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 182 PG----------YVLFSAlgSFYVPLTIILVMYCRVYVVakresrglksgLKTDKSDSEQvTLRIHRknvpaegsgvsSA 251
Cdd:cd15390  159 DGpnslqdfvynIVLFVV--TYFLPLIIMAVAYTRVGVE-----------LWGSKTIGEN-TPRQLE-----------SV 213
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 252 KNKthfsvrllkfsreKKAAKTLGIVVGCFVLCWLP---FFLVMPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIYPC 328
Cdd:cd15390  214 RAK-------------RKVVKMMIVVVVIFAICWLPyhlYFILTYLYPDINSWKYIQQIYLAIYWLAMSNSMYNPIIYCW 280

                 ....*....
gi 755547671 329 SSQEFKKAF 337
Cdd:cd15390  281 MNKRFRYGF 289
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
31-337 2.75e-34

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 129.51  E-value: 2.75e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  31 VILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCC 110
Cdd:cd14971    5 LFFALIFLLGLVGNSLVILVVARNKPMRSTTNLFILNLAVADLTFLLFCVPFTATIYPLPGWVFGDFMCKFVHYFQQVSM 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 111 TASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISI--GPLFGWRQQAPEDETICQINEEP-----G 183
Cdd:cd14971   85 HASIFTLVAMSLDRFLAVVYPLRSLHIRTPRNALAASGCIWVVSLAVAApvLALHRLRNYTPGNRTVCSEAWPSrahrrA 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 184 YVLFSALGSFYVPLTIILVMYCRVYVvakresrglksglktdksdseqvtlRIHRKNVPAEGSGVSSAKnkthfsvrllk 263
Cdd:cd14971  165 FALCTFLFGYLLPLLLICVCYAAMLR-------------------------HLWRVAVRPVLSEGSRRA----------- 208
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755547671 264 fsrEKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFP-NFKPPETVFKIV-FWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd14971  209 ---KRKVTRLVLVVVVLFAACWGPIHAILLLVALGPfPLTYATYALRIWaHCLAYSNSAVNPVLYAFLSEHFRKAF 281
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
36-337 5.32e-34

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 128.80  E-value: 5.32e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  36 LIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFsAIFEIL--GYWAFGRVFCNIWAAVDVLCCTAS 113
Cdd:cd15306   10 VIIPTIGGNILVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPI-ALLTILfeAMWPLPLVLCPIWLFLDVLFSTAS 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 114 IMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIG-PLFGWRQQAPEDETI-CQINEEP--GYVLFSA 189
Cdd:cd15306   89 IMHLCAISLDRYIAIKKPIQASQYNSRATAFIKITVVWLISIGIAIPvPIKGIETDVDNPNNItCVLTKERfgDFILFGS 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 190 LGSFYVPLTIILVMYCrvyvvakresrglksglktdksdseqVTLRIHRKNVpaegsgvssaknkthfsvrllkFSREKK 269
Cdd:cd15306  169 LAAFFTPLAIMIVTYF--------------------------LTIHALRKQT----------------------ITNEQR 200
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755547671 270 AAKTLGIVVGCFVLCWLPFFLVmPIGSFFPNFKPPETV---FKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15306  201 ASKVLGIVFFLFLLMWCPFFIT-NITSVLCDSCNQTTLqmlMEIFVWIGYVSSGVNPLVYTLFNKTFRDAF 270
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
27-334 7.14e-33

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 126.09  E-value: 7.14e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVD 106
Cdd:cd15391    1 PHLINLYQSTIFLSVGGNYSVIVVFYDGRRSRTDLNYYLINLAVSDLIMALFCMPFTFTQIMLGHWVFPAPMCPIVLYVQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIGVSYPLRypTIVTQRRGVRALLCVWALSLVISIGPLFGWR----QQAPEDETICQ----- 177
Cdd:cd15391   81 LVSVTASVLTNTAIGIDRFFAVIFPLR--SRHTKSRTKCIIASIWAISFSLSSVQLFAGRtqryGQYSEGRVLCGeswpg 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 178 -INEEPGYVLFSALGSFYVPLTIILVMYCRV-YVVAKRESRGlksglktdKSDSEQVTLRIHRKnvpaegsgvssaknkt 255
Cdd:cd15391  159 pDTSRSAYTVFVMLLTYIIPLLILTSTYGYVgFRLWNRTAPG--------NADKGRDDMQIKSK---------------- 214
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 256 hfsvrllkfsreKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKP-PETVFKIVF----WLGYLNSCINPIIYPCSS 330
Cdd:cd15391  215 ------------RKVIKMLVFVVLMFGICWLPLHLFNLVQDFSTVFRNmPQHTTRLIYgachWIAMSNSFVNPIIYLFMN 282

                 ....
gi 755547671 331 QEFK 334
Cdd:cd15391  283 DSFR 286
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
30-337 1.34e-32

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 125.18  E-value: 1.34e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  30 GVILGGLIIFGVLGNILVILSVACHRHL-HSVTHYYIVNLAVADLLlTSTVLPFSAIFEILGY-WAFGRVFCNIWAAVDV 107
Cdd:cd15104    3 GVILAVLSPLIITGNLLVIVALLKLIRKkDTKSNCFLLNLAIADFL-VGLAIPGLATDELLSDgENTQKVLCLLRMCFVI 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 108 LCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQAPEDETIC----QINEEPG 183
Cdd:cd15104   82 TSCAASVLSLAAIAFDRYLALKQPLRYKQIMTGKSAGALIAGLWLYSGLIGFLPLISPQFQQTSYKGKCsffaAFHPRVL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 184 YVLFSALgsFYVPLTIILVMYCRVYVVAKRESRGLKsglktdksDSEQVTLRIHRKNvpaegsgvssaknkthfsvrllK 263
Cdd:cd15104  162 LVLSCMV--FFPALLLFVFCYCDILKIARVHSRAIY--------KVEHALARQIHPR----------------------R 209
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755547671 264 FSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15104  210 TLSDFKAARTVAVLIGCFLLSWLPFQITGLVQALCDECKLYDVLEDYLWLLGLCNSLLNPWIYAFWQKEVRRAL 283
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
36-337 3.24e-32

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 124.27  E-value: 3.24e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  36 LIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEIlgywAFGRVF--CNIWAAVDVLCCTAS 113
Cdd:cd15069   10 IAALSVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIPFAITISL----GFCTDFhsCLFLACFVLVLTQSS 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 114 IMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQapedETICQINEEPG---------- 183
Cdd:cd15069   86 IFSLLAVAVDRYLAIKVPLRYKSLVTGKRARGVIAVLWVLAFGIGLTPFLGWNKA----MSATNNSTNPAdhgtnhsccl 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 184 -------------YVLFSALGSFYVPLTIILVMYCRVYVVAKRESRglksglKTDKSDSEQVTLRihrknvpaegsgvss 250
Cdd:cd15069  162 isclfenvvpmsyMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQ------RTELMDHSRTTLQ--------------- 220
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 251 aknkthfsvrllkfsREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNF--KPPETVFKIVFWLGYLNSCINPIIYPC 328
Cdd:cd15069  221 ---------------REIHAAKSLAIIVGIFALCWLPVHILNCITLFQPEFskSKPKWAMNVAILLSHANSVVNPIVYAY 285

                 ....*....
gi 755547671 329 SSQEFKKAF 337
Cdd:cd15069  286 RNRDFRYTF 294
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
27-337 4.65e-32

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 123.67  E-value: 4.65e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVD 106
Cdd:cd15393    1 VLLSILYGIISLVAVVGNFLVIWVVAKNRRMRTVTNIFIANLAVADIIIGLFSIPFQFQAALLQRWVLPRFMCPFCPFVQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIGVSYPLRypTIVTQRRGVRALLCVWALSLVISI-GPLFGWRQQAPEDET-----IC-QIN 179
Cdd:cd15393   81 VLSVNVSVFTLTVIAVDRYRAVIHPLK--ARCSKKSAKIIILIIWILALLVALpVALALRVEELTDKTNngvkpFClPVG 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 180 EEPG----YVLFSALGSFYVPLTIILVMYCRVYVvakrESRGLKSglktdkSDSEQVTLRIHRKnvpaegsgvssaKNKt 255
Cdd:cd15393  159 PSDDwwkiYNLYLVCVQYFVPLVIICYAYTRIAV----KIWGTKA------PGNAQDVRDDEIL------------KNK- 215
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 256 hfsvrllkfsreKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFP---NFKPPETVFKIVFWLGYLNSCINPIIYPCSSQE 332
Cdd:cd15393  216 ------------KKVIKMLIIVVALFALCWLPLQTYNLLNEIKPeinKYKYINIIWFCSHWLAMSNSCYNPFIYGLYNEK 283

                 ....*
gi 755547671 333 FKKAF 337
Cdd:cd15393  284 FKREF 288
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
41-337 5.14e-32

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 123.35  E-value: 5.14e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  41 VLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFsAIFEILGYwAFGRVFCNIWAAVDVLCCTASIMGLCII 120
Cdd:cd15070   15 VVGNVLVIWVVKLNPSLRTTTFYFIVSLALADIAVGVLVIPL-AIVVSLGV-TIHFYSCLFMSCLLVVFTHASIMSLLAI 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 121 SIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQAPEDETI-----CQINEEPG---YVLFSALGS 192
Cdd:cd15070   93 AVDRYLRVKLTVRYRIVTTQRRIWLALGLCWLVSFLVGLTPMFGWNRKPSLESVNttplqCQFTSVMRmdyMVYFSFFTW 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 193 FYVPLTIILVMYCRV-YVVAKRESRGLksglktdksdseqvtlrihrknvpaegsgvSSAKNKTHFsvrllkFSREKKAA 271
Cdd:cd15070  173 ILIPLVIMCALYVDIfYIIRNKLSQNA------------------------------TGFRETGAF------YGREFKTA 216
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755547671 272 KTLGIVVGCFVLCWLPFFLVMPIGSFFPNFkpPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15070  217 KSLALVLFLFAVCWLPLSIINCVVYFNPKV--PKIALYLGILLSHANSMMNPIVYACKIKKFKETY 280
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
27-337 5.64e-32

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 123.62  E-value: 5.64e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFE-ILGYWAFGRVFCNIWAAV 105
Cdd:cd15392    1 VIIILMYSTIFVLAVGGNGLVCYIVVSYPRMRTVTNYFIVNLALSDILMAVFCVPFSFIALlILQYWPFGEFMCPVVNYL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 106 DVLCCTASIMGLCIISIDRYIGVSYPLRYPtiVTQRRGVRALLCVWALSLVISIGPLFGWR----QQAPEDETIC----- 176
Cdd:cd15392   81 QAVSVFVSAFTLVAISIDRYVAIMWPLRPR--MTKRQALLLIAVIWIFALATALPIAITSRlfedSNASCGQYICteswp 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 177 QINEEPGYVLFSALGSFYVPLTIILVMYCRVyvvakresrglksglktdksdseqvTLRIHRKNVPAEGSgvssaknkth 256
Cdd:cd15392  159 SDTNRYIYSLVLMILQYFVPLAVLVFTYTRI-------------------------GIVVWAKRTPGEAE---------- 203
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 257 fSVRLLKFSREK-KAAKTLGIVVGCFVLCWLPF---FLVMPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIYPCSSQE 332
Cdd:cd15392  204 -NNRDQRMAESKrKLVKMMITVVAIFALCWLPLnilNLVGDHDESIYSWPYIPYLWLAAHWLAMSHCCYNPFIYCWMNAK 282

                 ....*
gi 755547671 333 FKKAF 337
Cdd:cd15392  283 FRNGF 287
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
23-326 9.56e-32

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 123.25  E-value: 9.56e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  23 ISKAILLGVILggliIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLT-STVLPfSAIFEILGYWAFGRVFCNI 101
Cdd:cd14986    1 VSRVAVLGVLF----VFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVVAfFTVLT-QIIWEATGEWVAGDVLCRI 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 102 WAAVDVLCCTASIMGLCIISIDRYIGVSYPLRypTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQAPED-ETICQ--I 178
Cdd:cd14986   76 VKYLQVVGLFASTYILVSMSLDRYQAIVKPMS--SLKPRKRARLMIVVAWVLSFLFSIPQLVIFVERELGDgVHQCWssF 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 179 NEEPG---YVLFSALGSFYVPLTIILVMYCRV-YVVAKRESRGLKSGLKTDKSDSEQVTLRIHRknvpaeGSGVSSAKNK 254
Cdd:cd14986  154 YTPWQrkvYITWLATYVFVIPLIILSYCYGRIlRTIWIRSRQKTDRPIAPTAMSCRSVSCVSSR------VSLISRAKIK 227
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755547671 255 ThfsVRLlkfsrekkaakTLGIVVGcFVLCWLPFFLVMPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIY 326
Cdd:cd14986  228 T---IKM-----------TLVIILA-FILCWTPYFIVQLLDVYAGMQQLENDAYVVSETLASLNSALNPLIY 284
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
38-337 1.24e-31

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 122.22  E-value: 1.24e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  38 IFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTvLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMGL 117
Cdd:cd15972   12 VVGLGGNTLVIYVVLRYSASESVTNIYILNLALADELFMLG-LPFLAAQNALSYWPFGSFMCRLVMTVDAINQFTSIFCL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 118 CIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFgwRQQAPEDETICQIN-EEP------GYVLFSAL 190
Cdd:cd15972   91 TVMSVDRYLAVVHPIRSSKWRKPPVAKTVNATVWALSFLVVLPVVI--FSGVPGGMGTCHIAwPEPaqvwraGFIIYTAT 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 191 GSFYVPLTIILVmyCRVYVVAKRESRGLKsglktdksdseqvtlrihrknvpaegsgVSSAKNKTHFSvrllkfsrEKKA 270
Cdd:cd15972  169 LGFFCPLLVICL--CYLLIVVKVRSSGRR----------------------------VRATSTKRRGS--------ERKV 210
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755547671 271 AKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPET--VFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15972  211 TRMVVIVVAAFVLCWLPFYALNIVNLVCPLPEEPSLfgLYFFVVVLSYANSCANPIIYGFLSDNFKQGF 279
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
27-337 1.48e-31

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 121.94  E-value: 1.48e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVlPFSAIFEILGYWAFGRVFCNIWAAVD 106
Cdd:cd15970    1 ILISFIYSVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIADELLMLSV-PFLVTSTLLRHWPFGSLLCRLVLSVD 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIGVSYPL-----RYPTIVTQRRgvralLCVWALSLVIsIGPLFGWRQQAPEDETICQIN-- 179
Cdd:cd15970   80 AINMFTSIYCLTVLSIDRYIAVVHPIkaaryRRPTVAKMVN-----LGVWVFSILV-ILPIIIFSNTAPNSDGSVACNmq 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 180 -EEP------GYVLFSALGSFYVPLTIILVmyCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHrknvpaegsgvssak 252
Cdd:cd15970  154 mPEPsqrwlaVFVVYTFLMGFLLPVIAICL--CYILIIVKMRVVALKAGWQQRKRSERKITLMVM--------------- 216
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 253 nkthfsvrllkfsrekkaaktlgIVVGCFVLCWLPFFLVMPIGSFFPnfKPPETVFKIVFWLGYLNSCINPIIYPCSSQE 332
Cdd:cd15970  217 -----------------------MVVTVFVICWMPFYVVQLVSVFVG--QHDATVSQLSVILGYANSCANPILYGFLSDN 271

                 ....*
gi 755547671 333 FKKAF 337
Cdd:cd15970  272 FKRSF 276
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
38-337 1.54e-31

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 122.26  E-value: 1.54e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  38 IFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTvLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMGL 117
Cdd:cd15971   12 IIGLCGNTLVIYVILRYAKMKTVTNIYILNLAIADELFMLG-LPFLAIQVALVHWPFGKAICRVVMTVDGINQFTSIFCL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 118 CIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQAPEDETICQINEE-------PGYVLFSAL 190
Cdd:cd15971   91 TVMSIDRYLAVVHPIKSAKWRKPRTAKMINMAVWGVSLLVILPIMIYAGVQTKHGRSSCTIIWPgessawyTGFIIYTFI 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 191 GSFYVPLTIILVmyCRVYVVAKRESRGLKSGlktdksdseqvtlrihrknvpaegsgvSSAKNKThfsvrllkfsrEKKA 270
Cdd:cd15971  171 LGFFVPLTIICL--CYLFIIIKVKSSGIRVG---------------------------SSKRKKS-----------EKKV 210
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 271 AKTLGIVVGCFVLCWLPFFlVMPIGSFFPNFKPP---ETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15971  211 TRMVSIVVAVFVFCWLPFY-IFNVSSVSVSISPTpglKGMFDFVVVLSYANSCANPILYAFLSDNFKKSF 279
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
27-335 3.53e-31

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 121.22  E-value: 3.53e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTvLPFSAIFEILG-YWAFGRVFCNIWAAV 105
Cdd:cd14982    1 TLFPIVYSLIFILGLLGNILALWVFLRKMKKRSPTTIYMINLALADLLFVLT-LPFRIYYYLNGgWWPFGDFLCRLTGLL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 106 DVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIgPLFGWRQQAPEDE--TIC--QINEE 181
Cdd:cd14982   80 FYINMYGSILFLTCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWILVLVASV-PLLLLRSTIAKENnsTTCfeFLSEW 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 182 PG----YVLFSALGSFYVPLTIILVMYCRVYVVAKREsrglksglktdksdseqvtlrihrknvpaegsgvssaknkthf 257
Cdd:cd14982  159 LAsaapIVLIALVVGFLIPLLIILVCYSLIIRALRRR------------------------------------------- 195
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 258 SVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIG-----SFFPNFKPPETVFK---IVFWLGYLNSCINPIIYPCS 329
Cdd:cd14982  196 SKQSQKSVRKRKALRMILIVLAVFLVCFLPYHVTRILYllvrlSFIADCSARNSLYKayrITLCLASLNSCLDPLIYYFL 275

                 ....*.
gi 755547671 330 SQEFKK 335
Cdd:cd14982  276 SKTFRK 281
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
27-337 6.28e-31

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 120.69  E-value: 6.28e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVD 106
Cdd:cd15202    1 VLLIVAYSFIIVFSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLFNTPFTFVRAVNNTWIFGLFMCHFSNFAQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIGVSYPLRyPTIvTQRRGVRALLCVWALSLVISIGPLFGWRQQAPEDET-----ICQIN-- 179
Cdd:cd15202   81 YCSVHVSAYTLTAIAVDRYQAIMHPLK-PRI-SKTKAKFIIAVIWTLALAFALPHAICSKLETFKYSEdivrsLCLEDwp 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 180 -----EEPGYVLFSALGSFYVPLTIILVMYCRVyvvakresrglksglktdksdseqvTLRIHRKNVPAEGSGvssakNK 254
Cdd:cd15202  159 eradlFWKYYDLALFILQYFLPLLVISFAYARV-------------------------GIKLWASNMPGDATT-----ER 208
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 255 THFSVRllkfsREKKAAKTLGIVVGCFVLCWLPF--FLVMPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIYPCSSQE 332
Cdd:cd15202  209 YFALRR-----KKKKVIKMLMVVVVLFALCWLPFniYVLLLSSKPDYLIKTINAVYFAFHWLAMSSTCYNPFIYCWLNER 283

                 ....*
gi 755547671 333 FKKAF 337
Cdd:cd15202  284 FRIEF 288
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
36-337 9.71e-31

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 119.29  E-value: 9.71e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  36 LIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIM 115
Cdd:cd15210   10 FMVVGVPGNLLTVLALLRSKKLRTRTNAFIINLSISDLLFCAFNLPLAASTFLHQAWIHGETLCRVFPLLRYGLVAVSLL 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 116 GLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQAPEDETI--CQINEE-----PGYVLFS 188
Cdd:cd15210   90 TLVLITLNRYILIAHPSLYPRIYTRRGLALMIAGTWIFSFGSFLPLWLGIWGRFGLDPKVcsCSILRDkkgrsPKTFLFV 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 189 AlgSFYVPLTIILVMYCRvyvvakresrglksglktdksdseqvtlrihrknvpaegsgvssaknkthfsvrllkfSREK 268
Cdd:cd15210  170 F--GFVLPCLVIIICYAR----------------------------------------------------------REDR 189
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755547671 269 KAAKTLGIVVGCFVLCWLPFFLVmpiGSFFPNFKPPEtVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15210  190 RLTRMMLVIFLCFLVCYLPITLV---NVFDDEVAPPV-LHIIAYVLIWLSSCINPIIYVAMNRQYRQAY 254
7tmA_Histamine_H4R cd15295
histamine receptor subtype H4R, member of the class A family of seven-transmembrane G ...
41-341 3.84e-30

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtype H4R, a member of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320422 [Multi-domain]  Cd Length: 267  Bit Score: 118.00  E-value: 3.84e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  41 VLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMGLCII 120
Cdd:cd15295   15 VLGNALVIIAFVVDKNLRHRSNYFFLNLAISDFFVGAISIPLYIPYTLTNRWDFGRGLCVFWLVIDYLLCTASVYNIVLI 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 121 SIDRYIGVSYPLRYPTIVTQ-RRGVRALLCVWALSLVISiGP--LFGWRQQAPEDETICQINEEPGYVLFSALGSFYVPl 197
Cdd:cd15295   95 SYDRYQSVSNAVSYRNQQTAtLRIVTQMVAVWVLAFLVH-GPaiLVSDSWKTEDGECEPEFFSNWYILAITSVLEFLVP- 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 198 tIILVMYCRVYVvakresrglksglktdksdseqvtlrihrknvpaegsgvssaknktHFSVRllKFSREKKAAKTLGIV 277
Cdd:cd15295  173 -VILVAYFNTQI----------------------------------------------YWSLW--KRLRDRKLAKSLAII 203
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755547671 278 VGCFVLCWLPFFLvMPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVL 341
Cdd:cd15295  204 LGTFAICWAPYSL-FTIIRAACEKHRGSPWYNFAFWLQWFNSFINPFLYPLCHKRFRKAFLKIF 266
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
27-335 5.46e-30

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 117.94  E-value: 5.46e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVD 106
Cdd:cd15088    1 VIMPSVFGCICVVGLVGNGIVLYVLVRCSKLRTAPDIFIFNLAVADLLFMLGMPFLIHQFAIDGQWYFGEVMCKIITALD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLvISIGPL--FGWRQQAPEDETICQINEEPG- 183
Cdd:cd15088   81 ANNQFTSTYILTAMSVDRYLAVVHPIRSTKYRTRFVAKLVNVGLWAASF-LSILPVwvYSSLIYFPDGTTFCYVSLPSPd 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 184 ----YVLFSALGSFYVPLTIILVMYCRVyvvakresrglksglktdksdseqvtlrIHRKNVPAEGSGVSSAKNKThfsv 259
Cdd:cd15088  160 dlywFTIYHFILGFAVPLVVITVCYILI----------------------------LHRLARGVAPGNQSHGSSRT---- 207
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 260 rllkfsreKKAAKTLGIVVGCFVLCWLPFFLVMPIGSffpNFKPPETVFKIVFW----LGYLNSCINPIIYPCSSQEFKK 335
Cdd:cd15088  208 --------KRVTKMVILIVVVFIVCWLPFHVVQLVNL---AMNRPTLAFEVAYFlsicLGYANSCLNPFVYILVSENFRK 276
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
28-326 7.91e-30

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 117.68  E-value: 7.91e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  28 LLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTvLPFSAIFEILGYWAFGRVFCNIWAAVDV 107
Cdd:cd15079    2 LLGFIYIFLGIVSLLGNGLVIYIFSTTKSLRTPSNMLVVNLAISDFLMMIK-MPIFIYNSFYEGWALGPLGCQIYAFLGS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 108 LCCTASIMGLCIISIDRYIGVSYPLRyPTIVTQRRGVRALLCVWALSLVISIGPL-FGWRQQAPEDE-TICQI----NEE 181
Cdd:cd15079   81 LSGIGSIWTNAAIAYDRYNVIVKPLN-GNPLTRGKALLLILFIWLYALPWALLPLlFGWGRYVPEGFlTSCSFdyltRDW 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 182 PG--YVLFSALGSFYVPLTIILVMYCR-VYVVAKRESrglksglktdksdseqvTLRIHRKNVPAEGSGVSSAKNKThfs 258
Cdd:cd15079  160 NTrsFVATIFVFAYVIPLIIIIYCYSFiVKAVFAHEK-----------------ALREQAKKMNVVSLRSNADANKQ--- 219
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755547671 259 vrllkfSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSffpnFKPPETVFKIVFWLGYL----NSCINPIIY 326
Cdd:cd15079  220 ------SAEIRIAKVALTNVFLWFIAWTPYAVVALIGA----FGNQSLLTPLVSMIPALfaktAACYNPIVY 281
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
27-337 8.74e-30

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 117.75  E-value: 8.74e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVIlgglIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVD 106
Cdd:cd15927    5 ILFALI----FLVGVLGNGTLILIFLRNKSMRNVPNIFILSLALGDLLLLLTCVPFTSTIYTLDSWPFGEFLCKLSEFLK 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFG---WRQQAPEDETI--CQINEE 181
Cdd:cd15927   81 DTSIGVSVFTLTALSADRYFAIVNPMRKHRSQATRRTLVTAASIWIVSILLAIPEAIFshvVTFTLTDNQTIqiCYPYPQ 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 182 P-------GYVLFSALGSFYVPLTIILVMYCrvyVVAKResrglksglktdksdseqvtLRIHRKNVPAEGSGVSSAKNK 254
Cdd:cd15927  161 ElgpnypkIMVLLRFLVYYLIPLLIIGVFYV---LMARH--------------------LIRSTRNIGSGQNQAAQRQIE 217
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 255 ThfsvrllkfsrEKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPET----VFKIV-FWLGYLNSCINPIIYPCS 329
Cdd:cd15927  218 A-----------RKKVAKTVLAFVVLFAVCWLPRHVFMLWFHFAPNGLVDYNafwhVLKIVgFCLSFINSCVNPVALYLL 286

                 ....*...
gi 755547671 330 SQEFKKAF 337
Cdd:cd15927  287 SGSFRRHF 294
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
27-337 1.36e-29

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 117.04  E-value: 1.36e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTV-LPFSAIFEILGYWAFGRVFCNIWAAV 105
Cdd:cd15337    1 YLIGIYIAIVGILGVIGNLLVIYLFSKTKSLRTPSNMFIINLAISDFGFSAVNgFPLKTISSFNKKWIWGKVACELYGFA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 106 DVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQAPED-ETICQ---INEE 181
Cdd:cd15337   81 GGIFGFMSITTLAAISIDRYLVIAKPLEAMKKMTFKRAFIMIIIIWLWSLLWSIPPFFGWGRYVPEGfQTSCTfdyLSRD 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 182 PGYVLFSA---LGSFYVPLTIILVMYCRVYVVAKRESRglksglktdksdseqvTLRIHRKNVPAEGSGVSSAKNKThfs 258
Cdd:cd15337  161 LNNRLFILglfIFGFLCPLLIIIFCYVNIIRAVRNHEK----------------EMTQTAKSGMGKDTEKNDARKKA--- 221
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755547671 259 vrllkfsrEKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15337  222 --------EIRIAKVAIILISLFLLSWTPYAVVALLGQFGPAYWITPYVSELPVMFAKASAIYNPIIYALSHPKFRAAL 292
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
27-337 5.81e-29

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 114.90  E-value: 5.81e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTvLPFSAIFEILGYWAFGRVFCNIWAAVD 106
Cdd:cd15974    1 VLIPVIYLLVCAIGLSGNTLVIYVVLRYAKMKTVTNIYILNLAVADELFMLG-LPFLATQNAISYWPFGSFLCRLVMTVD 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIgPLFGWRQQAPEDETiCQIN-EEP--- 182
Cdd:cd15974   80 GVNQFTSIFCLTVMSIDRYLAVVHPIKSTKWRRPRVAKLINATVWTLSFLVVL-PVIIFSDVQPDLNT-CNISwPEPvsv 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 183 ---GYVLFSALGSFYVPLTIILVmyCRVYVVAKRESRGLKSGlktdksdseqvtlrihrknvpaegsgvSSAKNKThfsv 259
Cdd:cd15974  158 wstAFIIYTAVLGFFGPLLVICL--CYLLIVIKVKSSGLRVG---------------------------STKRRKS---- 204
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 260 rllkfsrEKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFpnFKPPETVFKIVFW----LGYLNSCINPIIYPCSSQEFKK 335
Cdd:cd15974  205 -------ERKVTRMVVIIVVVFVFCWLPFYMLNIVNLIV--ILPEEPAFVGVYFfvvvLSYANSCANPILYGFLSDNFKQ 275

                 ..
gi 755547671 336 AF 337
Cdd:cd15974  276 SF 277
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
28-335 8.03e-29

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 114.85  E-value: 8.03e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  28 LLGVILGGLIIFGVLGNILVILsVACHRHLHSVTHY-YIVNLAVADLLLTSTVlPFSAIFEILGYWAFGRVFCNIWAAVD 106
Cdd:cd14999    1 AIGTVLSLMCVVGVAGNVYTLV-VMCLSMRPRASMYvYILNLALADLLYLLTI-PFYVSTYFLKKWYFGDVGCRLLFSLD 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLcVWALSLVISIGPLFGWRQQAPED-----ETIC----Q 177
Cdd:cd14999   79 FLTMHASIFTLTVMSTERYLAVVKPLDTVKRSKSYRKLLAGV-IWLLSLLLTLPMAIMIRLVTVEDksggsKRIClptwS 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 178 INEEPGY--VLFSAlgSFYVPLTIILVMYCRVyvvakresrglksglktdksdseqvtLRIHRknVPAEGSGVSSAKNKt 255
Cdd:cd14999  158 EESYKVYltLLFST--SIVIPGLVIGYLYIRL--------------------------ARKYW--LSQAAASNSSRKRL- 206
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 256 hfsvrllkfSREKKAAKTLGIVVgCFVLCWLPFFLVMPIGSFFPNFKPPETVFKIVFW----LGYLNSCINPIIYPCSSQ 331
Cdd:cd14999  207 ---------PKQKVLKMIFTIVL-VFWACFLPFWIWQLLYLYSPSLSLSPRTTTYVNYlltcLTYSNSCINPFLYTLLTK 276

                 ....
gi 755547671 332 EFKK 335
Cdd:cd14999  277 NYKE 280
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
38-337 9.95e-29

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 114.18  E-value: 9.95e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  38 IFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVlPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMGL 117
Cdd:cd15973   12 LVGLIGNSMVIFVILRYAKMKTATNIYILNLAIADELFMLSV-PFLAASAALQHWPFGSAMCRTVLSVDGINMFTSVFCL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 118 CIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVIsIGPLFGWRQQAPEDETICQIN---EEPG----YVLFSAL 190
Cdd:cd15973   91 TVLSVDRYIAVVHPLRAARYRRPTVAKMINICVWILSLLV-ISPIIIFADTATRKGQAVACNliwPHPAwsaaFVIYTFL 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 191 GSFYVPltIILVMYCRVYVVAKRESRGLKSGLKTDKSDseqvtlrihrknvpaegsgvssaknkthfsvrllkfsrEKKA 270
Cdd:cd15973  170 LGFLLP--VLAIGLCYILIIGKMRAVALKAGWQQRRKS--------------------------------------EKKI 209
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755547671 271 AKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKppETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15973  210 TRMVLMVVTVFVICWMPFYVVQLLNLFLPRLD--ATVNHASLILSYANSCANPILYGFLSDNFRRSF 274
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
27-336 5.75e-28

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 112.43  E-value: 5.75e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVD 106
Cdd:cd15389    1 ALLIVAYSIIIVISLFGNSLVCHVIFKNKRMHTATNLFIVNLAVSDILITLLNTPFTLVRFVNSTWVFGKIMCHLSRFAQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIGVSYPLRyPTIvTQRRGVRALLCVWALSLVISI-----GPLFGWRQQAPEDETICQIN-E 180
Cdd:cd15389   81 YCSVYVSTLTLTAIALDRHRVILHPLK-PRI-TPCQGVVVIAIIWIMASCLSLphaiyQKLVEFEYSNERTRSRCLPSfP 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 181 EPG-----YVLFSALGSFYV-PLTIILVMYCRV-YVVAKRESRGlksglktDKSDSEQVTLRihRKNvpaegsgvssakn 253
Cdd:cd15389  159 EPSdlfwkYLDLATFILQYVlPLLIIGVAYTRVaKKLWLRNAIG-------DVTTEQYVAQR--RKK------------- 216
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 254 kthfsvrllkfsreKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPnFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEF 333
Cdd:cd15389  217 --------------KKTIKMLMLVVLLFAICWLPLNCYHVLLSSHP-IRSNSALFFAFHWLAMSSTCYNPFIYCWLNDSF 281

                 ...
gi 755547671 334 KKA 336
Cdd:cd15389  282 RSE 284
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
32-337 7.52e-28

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 112.57  E-value: 7.52e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  32 ILGGLIIF--GVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLC 109
Cdd:cd15205    4 VITYVLIFvlALFGNSLVIYVVTRKRAMRTATNIFICSLALSDLLITFFCIPFTLLQNISSNWLGGAFMCKMVPFVQSTA 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 110 CTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQAPED-----------ETICQI 178
Cdd:cd15205   84 VVTSILTMTCIAVERHQGIVHPLKMKWQYTNRRAFTMLGLVWIVSVIVGSPMLFVQQLEVKYDflyekrhvcclERWYSP 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 179 NEEPGYVLFSALGSFYVPLTIILVMYCRV-YVVAKRESRGLKSGLKTdksdseqvtlrIHRKNVPaegsgvssaknkthf 257
Cdd:cd15205  164 TQQKIYTTFILVILFLLPLTTMLFLYSRIgYELWIKKRVGDASVLQT-----------IHGIEMS--------------- 217
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 258 svrllKFSREKK-AAKTLGIVVGCFVLCWLPFFLV--MPIGSFFPNFKPPETV---FKIVFWLGYLNSCINPIIYPCSSQ 331
Cdd:cd15205  218 -----KISRKKKrAVKMMVTVVLLFAVCWAPFHVVhmMIEYSNLENKYDGVTIkliFAIVQLIGFSNSFNNPIVYAFMNE 292

                 ....*.
gi 755547671 332 EFKKAF 337
Cdd:cd15205  293 NFKKNF 298
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
36-337 1.05e-27

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 111.62  E-value: 1.05e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  36 LIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTvLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIM 115
Cdd:cd15090   10 VCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST-LPFQSVNYLMGTWPFGNILCKIVISIDYYNMFTSIF 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 116 GLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQAPEDETICQIN-EEPGYVLFSALG--- 191
Cdd:cd15090   89 TLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTfSHPSWYWENLLKicv 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 192 ---SFYVPLTIILVMYcrvyvvakresrGLksglktdksdseqVTLRIHrknvpaegsgvssaknkthfSVRLLKFSREK 268
Cdd:cd15090  169 fifAFIMPVLIITVCY------------GL-------------MILRLK--------------------SVRMLSGSKEK 203
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755547671 269 -----KAAKTLGIVVGCFVLCWLPFFLVMPIGSFfpnFKPPETVFKIVFW-----LGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15090  204 drnlrRITRMVLVVVAVFIVCWTPIHIYVIIKAL---VTIPETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCF 279
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
27-337 1.74e-27

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 110.81  E-value: 1.74e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTvLPFSAIFEILGYWAFGRVFCNIWAAVD 106
Cdd:cd15091    1 VIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTT-MPFQSTVYLMNSWPFGDVLCKIVISID 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGP--LFGWRQQAPEDETICQIN-EEPG 183
Cdd:cd15091   80 YYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAivLGGTKVREDVDSTECSLQfPDDD 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 184 YVLFSALG-------SFYVPLTIILVMYcrvyvvakresrglksglktdksdseqvTLRIHRKNvpaegsgvssaknkth 256
Cdd:cd15091  160 YSWWDTFMkicvfifAFVIPVLIIIVCY----------------------------TLMILRLK---------------- 195
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 257 fSVRLLKFSREK-----KAAKTLGIVVGCFVLCWLP---FFLVMPIGSfFPNFKPPETVFKIVFWLGYLNSCINPIIYPC 328
Cdd:cd15091  196 -SVRLLSGSREKdrnlrRITRLVLVVVAVFVVCWTPihiFILVEALGS-VSHSTAAVSSYYFCIALGYTNSSLNPILYAF 273

                 ....*....
gi 755547671 329 SSQEFKKAF 337
Cdd:cd15091  274 LDENFKRCF 282
7tmA_Adenosine_R_A1 cd15071
adenosine receptor subtype A1, member of the class A family of seven-transmembrane G ...
41-337 2.58e-27

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine A1 receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand. The A1 receptor has primarily inhibitory function on the tissues in which it is located. The A1 receptor slows metabolic activity in the brain and has a strong anti-adrenergic effects in the heart. Thus, it antagonizes beta1-adrenergic receptor-induced stimulation and thereby reduces cardiac contractility. The A1 receptor preferentially couples to G proteins of the G(i/o) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels.


Pssm-ID: 341323 [Multi-domain]  Cd Length: 290  Bit Score: 110.71  E-value: 2.58e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  41 VLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRvfCNIWAAVDVLCCTASIMGLCII 120
Cdd:cd15071   15 VPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAIIINIGPQTEFYS--CLMVACPVLILTQSSILALLAI 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 121 SIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQAPEDETICQINEEPGYVL-------------- 186
Cdd:cd15071   93 AVDRYLRVKIPTRYKSVVTPRRAAVAIAGCWILSFLVGLTPMFGWNNLNAVERAWAANSSMGELVIkcqfetvismeymv 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 187 -FSALGSFYVPLTIILVMYCRVYVVAkresrglksglktdksdseqvtlrihRKNVPAEGSGVSSAKNKThfsvrllkFS 265
Cdd:cd15071  173 yFNFFVWVLPPLLLMLLIYLEVFYLI--------------------------RKQLNKKVSSSSSDPQKY--------YG 218
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755547671 266 REKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15071  219 KELKIAKSLALILFLFALSWLPLHILNCITLFCPSCKKPMILTYIAIFLTHGNSAMNPIVYAFRIKKFRTTF 290
7tmA_GPR161 cd15214
orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G ...
38-326 3.34e-27

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR161, an orphan GPCR, is a negative regulator of Sonic hedgehog (Shh) signaling, which promotes the processing of zinc finger protein GLI3 into its transcriptional repressor form (GLI3R) during neural tube development. In the absence of Shh, this proteolytic processing is normally mediated by cAMP-dependent protein kinase A (PKA). GPR161 is recruited to primary cilia by a mechanism depends on TULP3 (tubby-related protein 3) and the intraflagellar complex A (IFT-A). Moreover, Gpr161 knockout mice show phenotypes observed in Tulp3/IFT-A mutants, and cause increased Shh signaling in the neural tube. Taken together, GPR161 negatively regulates the PKA-dependent GLI3 processing in the absence of Shh signal by coupling to G(s) protein, which causes activation of adenylate cyclase, elevated cAMP levels, and activation of PKA. Conversely, in the presence of Shh, GPR161 is removed from the cilia by internalization into the endosomal recycling compartment, leading to downregulation of its activity and thereby allowing Shh signaling to proceed. In addition, GPR161 is over-expressed in triple-negative breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression) and correlates with poor prognosis. Mutations of GPR161 have also been implicated as a novel cause for pituitary stalk interruption syndrome (PSIS), a rare congenital disease of the pituitary gland. GPR161 is a member of the class A family of GPCRs, which contains receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320342 [Multi-domain]  Cd Length: 261  Bit Score: 109.64  E-value: 3.34e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  38 IFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMGL 117
Cdd:cd15214   11 ILICLGNLVIVVTLYKKSYLLTLSNKFVFSLTLSNLLLSVLVLPFVVTSSIRREWIFGVVWCNFSALLYLLISSASMLTL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 118 CIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQ-QAPEDETICQI--NEEPGYVLFSALGSFY 194
Cdd:cd15214   91 GAIAIDRYYAVLYPMVYPMKITGNRAVLALVYIWLHSLIGCLPPLFGWSSlEFDRFKWMCVAawHKEAGYTAFWQVWCAL 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 195 VPLTIILVMYCRVYVVAKresrglksglktdksdseqvtlrihrknvpaegsgvssaknkthfsvrllkfSREKKAAKTL 274
Cdd:cd15214  171 LPFVVMLVCYGFIFRVAR----------------------------------------------------ANQCKAFITI 198
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 755547671 275 GIVVGCFVLCWLPFFLVMPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIY 326
Cdd:cd15214  199 LVVLGAFVTTWGPYMVVISTEALWGKNSVSPQLETLATWLSFTSAVCHPLIY 250
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
38-336 4.37e-27

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 110.19  E-value: 4.37e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  38 IFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMGL 117
Cdd:cd15336   12 ITGMLGNALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLTQSPIFFVNSLHKRWIFGEKGCELYAFCGALFGITSMITL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 118 CIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQAPED-ETICQ--------INEEPGYVLFS 188
Cdd:cd15336   92 LAISLDRYLVITKPLASIRWVSKKRAMIIILLVWLYSLAWSLPPLFGWSAYVPEGlLTSCTwdymtftpSVRAYTMLLFC 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 189 ALgsFYVPLTIILvmYCRVYVVAkresrglksglktdksdseqvTLRIHRKNVPAEGSGVSSAKNKTHFSVRllkfsREK 268
Cdd:cd15336  172 FV--FFIPLGIII--YCYLFIFL---------------------AIRSTGREVQKLGSQDRKEKAKQYQRMK-----NEW 221
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 269 KAAKTLGIVVGCFVLCWLPFFLVMPIGsffpnfkppetvfkivfWLGYLN----------------SCI-NPIIYPCSSQ 331
Cdd:cd15336  222 KMAKIAFVVILLFVLSWSPYACVALIA-----------------WAGYAHlltpymksvpaviakaSAIyNPIIYAITHP 284

                 ....*
gi 755547671 332 EFKKA 336
Cdd:cd15336  285 KYREA 289
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
27-335 4.43e-27

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 109.67  E-value: 4.43e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVD 106
Cdd:cd15074    1 IIIGIYLTVIGILSTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGYPLAIISAFAHRWLFGDIGCVFYGFCG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIGVSYPlRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQAPED-ETICQIN------ 179
Cdd:cd15074   81 FLFGCCSINTLTAISIYRYLKICHP-PYGPKLSRRHVCIVIVAIWLYALFWAVAPLVGWGSYGPEPfGTSCSIDwtgasa 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 180 --EEPGYVLFSALGSFYVPLTIILVMYCRVYVVAKresrglksglKTDKSDSEQVTLRIHRKNVpaegsgvssaknkthf 257
Cdd:cd15074  160 svGGMSYIISIFIFCYLLPVLIIVFSYVKIIRKVK----------SSRKRVAGFDSRSKRQHKI---------------- 213
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755547671 258 svrllkfsrEKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKK 335
Cdd:cd15074  214 ---------ERKVTKVAVLICAGFLIAWTPYAVVSMWSAFGSPDSVPILASILPALFAKSSCMYNPIIYLLFSSKFRQ 282
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
38-337 1.18e-26

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 108.42  E-value: 1.18e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  38 IFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTvLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMGL 117
Cdd:cd15092   12 VVGLVGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLT-LPFQGTDIFLGFWPFGNALCKTVIAIDYYNMFTSTFTL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 118 CIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQAPEDETICQIN-------EEPGYVLFSAL 190
Cdd:cd15092   91 TAMSVDRYVAICHPIKALDVRTPHKAKVVNVCIWALASVVGVPVMVMGSAQVEDEEIECLVEiptpqdyWDPVFGICVFL 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 191 GSFYVPLTIILVMYcrvyvvakresrglksglktdksdseqvTLRIHRKNvpaegsgvssaknkthfSVRLLKFSREK-- 268
Cdd:cd15092  171 FSFIIPVLIISVCY----------------------------SLMIRRLR-----------------GVRLLSGSKEKdr 205
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 269 ---KAAKTLGIVVGCFVLCWLP---FFLVMPIGSffpnfkPPETVFKIVFW-----LGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15092  206 nlrRITRLVLVVVAVFVGCWTPiqiFVLAQGLGV------QPSSETAVAILrfctaLGYVNSSLNPVLYAFLDENFKACF 279
7tmA_CXCR1_2 cd15178
CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G ...
27-337 4.44e-26

CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR1 and CXCR2 are closely related chemotactic receptors for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. Expression of CXCR1 and CXCR2 is strictly controlled in neutrophils by external stimuli such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, Toll-like receptor agonists, and nitric oxide. CXCL8 (formerly known as interleukin-8) binds with high-affinity and activates both receptors. CXCR1 also binds CXCL7 (neutrophil-activating protein-2), whereas CXCR2 non-selectively binds to all seven ELR-positive chemokines (CXCL1-7). Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341333 [Multi-domain]  Cd Length: 279  Bit Score: 106.97  E-value: 4.44e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTvLPFSAIFEILGyWAFGRVFCNIWAAVD 106
Cdd:cd15178    1 LALCVIYVLVFLLSLPGNSLVVLVILYNRRSRSSTDVYLLHLAIADLLFALT-LPFWAVSVVKG-WIFGTFMCKLVSLLQ 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIGVSYPLRyptIVTQRRGVRALLC--VWALSLVISIgPLFGWRQQA---PEDETICQINEE 181
Cdd:cd15178   79 EANFYSGILLLACISVDRYLAIVHATR---ALTQKRHLVKFVCagVWLLSLLLSL-PALLNRDAFkppNSGRTVCYENLG 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 182 PG---------YVLFSALGsFYVPLTIILVMYcrvyvvakresrglksglktdksdseQVTLrihrknvpaegsgvssak 252
Cdd:cd15178  155 NEsadkwrvvlRILRHTLG-FLLPLVVMLFCY--------------------------GFTI------------------ 189
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 253 nKTHFSVRllkfSREK-KAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPET------VFKIVFW---LGYLNSCIN 322
Cdd:cd15178  190 -KTLLQTR----SFQKhRAMRVIFAVVLAFLLCWLPYNVTVLIDTLMRTKLITETcelrnhVDVALYVtqiLGFLHSCIN 264
                        330
                 ....*....|....*
gi 755547671 323 PIIYPCSSQEFKKAF 337
Cdd:cd15178  265 PVLYAFIGQKFRNNL 279
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
27-337 5.54e-26

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 106.73  E-value: 5.54e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILggliIFGVLGNILV--ILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAA 104
Cdd:cd15002    4 ILLGVIC----LLGFAGNLMVigILLNNARKGKPSLIDSLILNLSAADLLLLLFSVPFRAAAYSKGSWPLGWFVCKTADW 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 105 VDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIvTQRRGVRALLCVWALSLVISIgPLFGWR---QQAPEDETICQI--- 178
Cdd:cd15002   80 FGHACMAAKSFTIAVLAKACYMYVVNPTKQVTI-KQRRITAVVASIWVPACLLPL-PQWLFRtvkQSEGVYLCILCIppl 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 179 --NEEPGYVLFSALGSFYVPLTIILVMYCRVYVVAKResrglkSGLKTDksdseqvTLRIHRknvpaegsgvssaknkth 256
Cdd:cd15002  158 ahEFMSAFVKLYPLFVFCLPLTFALFYFWRAYGQCQR------RGTKTQ-------NLRNQI------------------ 206
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 257 fsvrllkfsREKKAAKTLGIVVGCFVLCWLP-FFLVMPIGSFFPNFKPPETVFKIVF-WLGYLNSCINPIIYPCSSQEFK 334
Cdd:cd15002  207 ---------RSRKLTHMLLSVVLAFTILWLPeWVAWLWLIHIKSSGSSPPQLFNVLAqLLAFSISSVNPIIFLLMSEEFR 277

                 ...
gi 755547671 335 KAF 337
Cdd:cd15002  278 EGF 280
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
36-336 6.26e-26

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 106.81  E-value: 6.26e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  36 LIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLlTSTVLPFSaIFEILGY--WAFGRVFCNIWAAVDVLCCTAS 113
Cdd:cd15928   10 LMLVGASGNLLTVLVIGRSRDMRTTTNLYLSSLAVSDLL-IFLVLPLD-LYRLWRYrpWRFGDLLCRLMYFFSETCTYAS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 114 IMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLvISIGP---LFGWRQ---QAPEDETICQIneepgYVLF 187
Cdd:cd15928   88 ILHITALSVERYLAICHPLRAKVLVTRGRVKLLIAVIWAVAI-VSAGPalvLVGVEHiqgQQTPRGFECTV-----VNVS 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 188 SALGS---------FYVPLTIILVMYcrvyvvakresrGLKSGLKTDKSDseqvtlrihrknvPAEGSGVSSAKNKthfs 258
Cdd:cd15928  162 SGLLSvmlwvstsfFFVPMVCLSLLY------------GLIGRALWDRRQ-------------RSRTAGASRRDNN---- 212
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 259 vrllkfsrEKKAAKTLGIVVGCFVLCWLPFFLVMPIgsFFPNFKPPETV------FKIV-FWLGYLNSCINPIIYPCSSQ 331
Cdd:cd15928  213 --------HRQTVRMLAVIVLAFVLCWLPFHVGRVI--FNHSRASTKHLhyvsqyFNLVsFVLFYLSAAINPILYNLMSK 282

                 ....*
gi 755547671 332 EFKKA 336
Cdd:cd15928  283 RYRYA 287
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
28-337 9.40e-26

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 106.02  E-value: 9.40e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  28 LLGVILGGLI-IFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTvLPFSAIFEILGYWAFGRVFCNIWAAVD 106
Cdd:cd15094    1 LISAVLYGLIcIVGLVGNGLVIYVVLRYAKMKTVTNLYILNLAVADECFLIG-LPFLIVTMILKYWPFGAAMCKIYMVLT 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIgPLFGWRQQAPED-ETICQI------- 178
Cdd:cd15094   80 SINQFTSSFTLTVMSADRYLAVCHPIRSMRYRTPFIAKVVCATTWSISFLVML-PIILYASTVPDSgRYSCTIvwpdssa 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 179 -NEEPGYVLFSALGSFYVPLTIILVMYcrVYVVAKRESRGLKSGlktdksdseqvtlrihrknvpaegsgvSSAKNKTHf 257
Cdd:cd15094  159 vNGQKAFTLYTFLLGFAIPLLLISVFY--TLVILRLRTVGPKNK---------------------------SKEKRRSH- 208
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 258 svrllkfsreKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPE----TVFKIVFWLGYLNSCINPIIYPCSSQEF 333
Cdd:cd15094  209 ----------RKVTRLVLTVISVYIICWLPYWAFQVHLIFLPPGTDMPkweiLMFLLLTVLSYANSMVNPLLYAFLSENF 278

                 ....
gi 755547671 334 KKAF 337
Cdd:cd15094  279 RKSF 282
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
36-337 1.11e-25

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 106.30  E-value: 1.11e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  36 LIIFGVLGNILVILSvACHRHLHSVTHY--YIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTAS 113
Cdd:cd15383   10 LFVLSACSNLAVLWS-ATRNRRRKLSHVriLILHLAAADLLVTFVVMPLDAAWNVTVQWYAGDLACRLLMFLKLFAMYSS 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 114 IMGLCIISIDRYIGVSYPLrypTIVTQRRGVRALLCV-WALSLVISIGPLFGWR---QQAPEDETIC-------QINEEP 182
Cdd:cd15383   89 AFVTVVISLDRHAAILNPL---AIGSARRRNRIMLCAaWGLSALLALPQLFLFHtvtATPPVNFTQCathgsfpAHWQET 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 183 GYVLFSALGSFYVPLTIILVMYCRVYVVAKRESRGLKSglktdkSDSEQVTLRIHRKNVPaegsgvsSAKNKThfsvrlL 262
Cdd:cd15383  166 LYNMFTFFCLFLLPLLIMIFCYTRILLEISRRMKEKKD------SAKNEVALRSSSDNIP-------KARMRT------L 226
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755547671 263 KFSRekkaaktlgIVVGCFVLCWLPFFLVMPIGSFFP---NFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15383  227 KMTI---------VIVSSFIVCWTPYYLLGLWYWFSPemlEQTVPESLSHILFLFGLLNACLDPLIYGLFTISFRRGL 295
7tmA_GPR101 cd15215
orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...
31-337 1.20e-25

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320343 [Multi-domain]  Cd Length: 261  Bit Score: 105.31  E-value: 1.20e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  31 VILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCC 110
Cdd:cd15215    4 VLIVIFLCASLFGNIVLLLVFQRKPQLLQVANRFIFNLLVADLLQTVLVMPWVIATSVPLFWPLDSHLCTALVVLMHLFA 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 111 TASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQA-PEDETICQI--NEEPGYVLF 187
Cdd:cd15215   84 FAGVNTIVVVSVDRYLAIIHPLSYPTKMTPRRGYLLIYGTWIVSVLQSTPPLYGWGQAAfDERNALCSViwGSSYSYTIL 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 188 SALGSFYVPLTIILVMYCRVYVVAKRESRGlksglktdksdseqvtlrihrknvpaegsgvssaknkthfsvrllkfsre 267
Cdd:cd15215  164 SVVSSFVLPVIIMLACYSMVFRAARRCYHC-------------------------------------------------- 193
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 268 kKAAKTLGIVVGCFVLCWLPfFLVMPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15215  194 -KAAKVIFIIIFSYVLSMGP-YSFLSVLAVWVDTQVPQWVISIILWLFFLQCCIHPYIYGYMHKSIKKEF 261
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
38-337 1.22e-25

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 105.80  E-value: 1.22e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  38 IFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTvLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMGL 117
Cdd:cd15089   12 VVGLLGNVLVMYGIVRYTKMKTATNIYIFNLALADALATST-LPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 118 CIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQAPEDETIC---QINEEPGY-----VLFSA 189
Cdd:cd15089   91 TMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLSSGVGVPIMVMAVTKTPRDGAVVcmlQFPSPSWYwdtvtKICVF 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 190 LGSFYVPLTIILVMYcrvyvvakresrGLksglktdksdseqVTLRIHrknvpaegsgvssaknkthfSVRLLKFSREK- 268
Cdd:cd15089  171 IFAFVVPILVITVCY------------GL-------------MILRLR--------------------SVRLLSGSKEKd 205
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755547671 269 ----KAAKTLGIVVGCFVLCWLPFFLVMPIGSFFP-NFKPPETV--FKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15089  206 rnlrRITRMVLVVVAAFIICWTPIHIFVIVWTLVDiDRRNPLVVaaLHLCIALGYANSSLNPVLYAFLDENFKRCF 281
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
36-326 2.30e-25

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 105.21  E-value: 2.30e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  36 LIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSA--IFEILGyWAFGRVFCNIWAAVDVLCCTAS 113
Cdd:cd15394   10 VVLVGVVGNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATCVPLTLayAFEPRG-WVFGRFMCYFVFLMQPVTVYVS 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 114 IMGLCIISIDRYIGVSYPLRYPtiVTQRRGVRALLCVWALSLVISIGPLFG--WRQQAPEDETIC------QINEEPGYV 185
Cdd:cd15394   89 VFTLTAIAVDRYYVTVYPLRRR--ISRRTCAYIVAAIWLLSCGLALPAAAHtyYVEFKGLDFSICeefwfgQEKQRLAYA 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 186 LFSALGSFYVPLTIILVMYCRVYVvakresrglksglktdksdseqvtlRIHRKNVPAEGSGVSSAKNKthfsvrllkfS 265
Cdd:cd15394  167 CSTLLITYVLPLLAISLSYLRISV-------------------------KLRNRVVPGSMTQSQAEWDR----------A 211
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755547671 266 REKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPETVFKI---VFWLGYLNSCINPIIY 326
Cdd:cd15394  212 RRRKTFRLLVVVVVAFAICWLPLHIFNVIRDIDIDLIDKQYFNLIqllCHWLAMSSACYNPFLY 275
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
25-343 3.13e-25

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 105.63  E-value: 3.13e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  25 KAILLGVILGGLIIFGVLGNILVILsVACHRHLHSVTHYYIVNLAVADLLLTSTvLPFSAIFEILGYWAFGRVFCNIWAA 104
Cdd:PHA03087  39 NSTILIVVYSTIFFFGLVGNIIVIY-VLTKTKIKTPMDIYLLNLAVSDLLFVMT-LPFQIYYYILFQWSFGEFACKIVSG 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 105 VDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQAPEDETICQI------ 178
Cdd:PHA03087 117 LYYIGFYNSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETTPILFVYTTKKDHETLICCMfynnkt 196
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 179 NEEPGYVLF--SALGsFYVPLTIILVMYCRVYVVAKResrglksglktdksdseqvtlrihrknvpaegsgvsSAKNKth 256
Cdd:PHA03087 197 MNWKLFINFeiNIIG-MLIPLTILLYCYSKILITLKG------------------------------------INKSK-- 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 257 fsvrllkfsREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFP-NFKPPETVFKIVFWLGY-------LNSCINPIIYPC 328
Cdd:PHA03087 238 ---------KNKKAIKLVLIIVILFVIFWLPFNVSVFVYSLHIlHFKSGCKAVKYIQYALHvteiislSHCCINPLIYAF 308
                        330
                 ....*....|....*
gi 755547671 329 SSQEFKKAFQNVLRI 343
Cdd:PHA03087 309 VSEFFNKHKKKSLKL 323
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
31-326 4.03e-25

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 104.44  E-value: 4.03e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  31 VILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCC 110
Cdd:cd15384    5 VVLAVMFVISFIGNLLTIIQIYRLRRSRRTIYSLLLHLAIADLLVTFFCIPSEAIWAYTVAWLAGNTMCKLVKYLQVFGL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 111 TASIMGLCIISIDRYIGVSYPLRYPTIVTQRRgvRALLCVWALSLVISIGPLFGW---RQQAPEDETIC-------QINE 180
Cdd:cd15384   85 YLSTYITVLISLDRCVAILYPMKRNQAPERVR--RMVTVAWILSPIFSIPQAVIFhveRGPFVEDFHQCvtygfytAEWQ 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 181 EPGYVLFSALGSFYVPLTIILVMYCRVYVVAKRESRGLKsGLKTDKSDSEQVTLRIHRKnvpaegsgvssAKNKthfSVR 260
Cdd:cd15384  163 EQLYNMLSLVFMFPIPLVIMVTCYVLIFITLSKSSRDFQ-GLEIYTRNRGPNRQRLFHK-----------AKVK---SLR 227
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755547671 261 LlkfsrekkaakTLGIVVGcFVLCWLPFFLVMPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIY 326
Cdd:cd15384  228 M-----------SAVIVTA-FILCWTPYYVIMIWFLFFNPYPLNDILFDVIFFFGMSNSCVNPLIY 281
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
28-337 5.95e-25

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 103.86  E-value: 5.95e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  28 LLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTS--TVLPFsaIFEILGYWAFGRVFCNIWAAV 105
Cdd:cd16003    2 LWSLAYGFVVAVAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASMAAfnTLINF--IYALHSEWYFGEAYCRFHNFF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 106 DVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVraLLCVWALSLVISIGPLFGWRQQAPEDETICQInEEPGyv 185
Cdd:cd16003   80 PITSVFASIYSMTAIAVDRYMAIIDPLKPRLSATATKVV--IGSIWILAFLLAFPQCLYSKTKVMPGRTLCFV-AWPG-- 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 186 lfSALGSFYVPLTIILVMYCRVYVVAkresrGLKSGLktdksdseqVTLRIHRKNVPAEGSgvssakNKTHFSVRllkfs 265
Cdd:cd16003  155 --GPDQHFTYHIIVIVLVYCLPLLVM-----GITYTI---------VGITLWGGEIPGDTS------DKYHEQLR----- 207
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755547671 266 REKKAAKTLGIVVGCFVLCWLP---FFLVMPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd16003  208 AKRKVVKMMIIVVLTFAICWLPyhiYFIVTGLYQQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFRAGF 282
7tmA_MC1R cd15351
melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...
36-335 1.08e-24

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320473 [Multi-domain]  Cd Length: 271  Bit Score: 102.95  E-value: 1.08e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  36 LIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFG---RVFCNIWAAVDVLCCTA 112
Cdd:cd15351   10 LGLVSLVENILVVVAIAKNRNLHSPMYYFICCLAVSDMLVSVSNLIETLFMLLLEHGVLVcraPMLQHMDNVIDTMICSS 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 113 ---SIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQApedeticqineepgyVLFSA 189
Cdd:cd15351   90 vvsSLSFLGAIAVDRYITIFYALRYHSIMTLQRAVNAIAGIWLASTVSSTLFIVYYNSNA---------------VILCL 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 190 LGSFYVPLTIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLrihrknvpaegsgvssaknkthfsvrllkfsrekK 269
Cdd:cd15351  155 IVFFLFMLVLMLVLYIHMFILACRHSQSISSQQRRQCPHQQTASL----------------------------------K 200
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755547671 270 AAKTLGIVVGCFVLCWLPFFLVMPI----------GSFFPNfkppetvFKIVFWLGYLNSCINPIIYPCSSQEFKK 335
Cdd:cd15351  201 GAITLTILLGIFFLCWGPFFLHLTLivtcpthpfcLCYFKY-------FNLFLILIICNSIIDPLIYAFRSQELRK 269
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
32-337 1.45e-24

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 102.86  E-value: 1.45e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  32 ILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCT 111
Cdd:cd15195    6 VTWVLFVISAAGNLTVLIQLFRRRRAKSHIQILIMHLALADLMVTFFNMPMDAVWNYTVEWLAGDLMCRVMMFLKQFGMY 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 112 ASIMGLCIISIDRYIGVSYPLrypTIVTQRRGVRALLCV-WALSLVISIGPLFGWRQQAPEDETI----C--------QI 178
Cdd:cd15195   86 LSSFMLVVIALDRVFAILSPL---SANQARKRVKIMLTVaWVLSALCSIPQSFIFSVLRKMPEQPgfhqCvdfgsaptKK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 179 NEEPgYVLFSALGSFYVPLTIILVMYCR-VYVVAKREsrglksglKTDKSDSEQVTLRIHRKNVPaegsgvsSAKNKThf 257
Cdd:cd15195  163 QERL-YYFFTMILSFVIPLIITVTCYLLiLFEISKMA--------KRARDTPISNRRRSRTNSLE-------RARMRT-- 224
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 258 svrlLKFSrekkaaktlGIVVGCFVLCWLPFFLVMPIGSFFP--NFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKK 335
Cdd:cd15195  225 ----LRMT---------ALIVLTFIVCWGPYYVLGLWYWFDKesIKNLPPALSHIMFLLGYLNPCLHPIIYGVFMKEIRN 291

                 ..
gi 755547671 336 AF 337
Cdd:cd15195  292 WI 293
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
31-326 1.52e-24

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 102.31  E-value: 1.52e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  31 VILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLtstvlpfsAIFEILGYWAF--------GRVFCNIW 102
Cdd:cd15196    5 AVLATILVLALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLLV--------ALFNVLPQLIWdityrfygGDLLCRLV 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 103 AAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLcVWALSLVISIGPLFGWRQQAP-EDETICQINEE 181
Cdd:cd15196   77 KYLQVVGMYASSYVLVATAIDRYIAICHPLSSHRWTSRRVHLMVAI-AWVLSLLLSIPQLFIFSYQEVgSGVYDCWATFE 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 182 PG-----YVLFSALGSFYVPLTIILVMYCRVYVVakresrglksglktdksdseqvtlrIHRknvpaegsgvssAKNKTh 256
Cdd:cd15196  156 PPwglraYITWFTVAVFVVPLIILAFCYGRICYV-------------------------VWR------------AKIKT- 197
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 257 fsVRLlkfsrekkaakTLGIVVgCFVLCWLPFFLVMPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIY 326
Cdd:cd15196  198 --VKL-----------TLVVVA-CYIVCWTPFFVVQMWAAWDPTAPIEGPAFVIIMLLASLNSCTNPWIY 253
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
29-337 1.55e-24

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 103.02  E-value: 1.55e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  29 LGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLltstVLPFSAIFEILGYWA-----FGRVFCNIWA 103
Cdd:cd15357    3 MSLVYAVIFVVGVIGNLLVCLVILKHQNMKTPTNYYLFSLAVSDLL----VLLFGMPLEVYEMWSnypflFGPVGCYFKT 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 104 AVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISI--GPLFGWRQQ-------APEDET 174
Cdd:cd15357   79 ALFETVCFASILSVTTVSVERYVAILHPFRAKLNSTRERALKIIVVLWVLSVLFSIpnTSIHGIKLQyfpngtlIPDSAT 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 175 ICQINEEPGYVLFSALGS--FYV-PLTIILVMYCRVyvvakresrGLKsgLKTDKS-DSEQVTLRIHRKNvpaegsgvss 250
Cdd:cd15357  159 CTVVKPLWIYNLIIQITSllFYVlPMGVISVLYYLM---------GLK--LRGDKSlEADEMNVNIQRPS---------- 217
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 251 aknkthfsvrllkfsrEKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPP-ETVFKIVFWLG----YLNSCINPII 325
Cdd:cd15357  218 ----------------RKSVTKMLFVLVLVFAICWAPFHVDRLFFSFVVEWTEPlANVFNLIHVVSgvffYLSSAVNPII 281
                        330
                 ....*....|..
gi 755547671 326 YPCSSQEFKKAF 337
Cdd:cd15357  282 YNLLSRRFRTAF 293
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
27-337 2.06e-24

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 102.75  E-value: 2.06e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAI-FEILGYWAFGRVFCNIWAAV 105
Cdd:cd14997    1 VLVSVVYGVIFVVGVLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLVCMPVALVeTWAREPWLLGEFMCKLVPFV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 106 DVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLF--GWRQQAPEDET---IC--QI 178
Cdd:cd14997   81 ELTVAHASVLTILAISFERYYAICHPLQAKYVCTKRRALVIIALIWLLALLTSSPVLFitEFKEEDFNDGTpvaVCrtPA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 179 NEE--PGYVLFSALGSFYVPLtIILVMycrVYVVAKRESRGLKSGLKTDKSDSEQVTLRiHRKNVpaegsgvssaknkth 256
Cdd:cd14997  161 DTFwkVAYILSTIVVFFVVPL-AILSG---LYSVICRRLVGHPALESRRADAANRHTLR-SRRQV--------------- 220
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 257 fsVRLlkfsrekkaaktLGIVVGCFVLCWLPFFLVMPIGSFFP--NFKP--PETVFKIVFW---LGYLNSCINPIIYPCS 329
Cdd:cd14997  221 --VYM------------LITVVVLFFVCLLPFRVVTLWIIFAPdeDLQAlgLEGYLNLLVFcrvMVYLNSALNPILYNLM 286

                 ....*...
gi 755547671 330 SQEFKKAF 337
Cdd:cd14997  287 STKFRSAF 294
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
27-337 2.11e-24

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 101.99  E-value: 2.11e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILsVACHRHLHSVTHYYIVNLAVADLLLTSTvLPFSAIFEILGY-WAFGRVFCNIWAAV 105
Cdd:cd14974    1 IVSLVLYALIFLLGLPGNGLVIW-VAGFKMKRTVNTVWFLNLALADFLFCLF-LPFLIVYIAMGHhWPFGSVLCKLNSFV 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 106 DVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIgPLFGWRQ------------QAPEDE 173
Cdd:cd14974   79 ISLNMFASVFLLTAISLDRCLLVLHPVWAQNHRTVRLASVVCVGIWILALVLSV-PYFVFRDtvthhngrscnlTCVEDY 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 174 TICQINEEPGYVlFSALGSFYVPLTIILVmyCRVYVVAKRESRGLksglktdksdseqvtlrihrknvpaegsgvssakn 253
Cdd:cd14974  158 DLRRSRHKALTV-IRFLCGFLLPLLIIAI--CYSVIAVKLRRKRL----------------------------------- 199
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 254 kthfsvrllkfSREKKAAKTLGIVVGCFVLCWLPF--FLVMPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIYPCSSQ 331
Cdd:cd14974  200 -----------AKSSKPLRVLLAVVVAFFLCWLPYhvFALLELVAAAGLPEVVLLGLPLATGLAYFNSCLNPILYVFMGQ 268

                 ....*.
gi 755547671 332 EFKKAF 337
Cdd:cd14974  269 DFRKRL 274
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
27-336 3.93e-24

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 100.90  E-value: 3.93e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVD 106
Cdd:cd15213    1 ITLAILMILMIFVGFLGNSIVCLIVYQKPAMRSAINLLLANLAFSDIMLSLVCMPFAAVTIITGRWIFGDIFCRISAMLY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIGVsypLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQ-QAPEDETIC--QINEEPG 183
Cdd:cd15213   81 WFFVLEGVAILLIISVDRYLII---VQRQDKLNPHRAKILIAVSWVLSFCVSFPPLVGWGKyEFPPRAPQCvlGYTESPA 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 184 ---YVLFSALGSFYVPLTIILvmYCrvYVVAKRESRGLKSglktdksdseqvtlrihrknvpaegsgvssaknkthfsvr 260
Cdd:cd15213  158 driYVVLLLVAVFFIPFLIML--YS--YFCILNTVRSFKT---------------------------------------- 193
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 261 llkfsrekKAAKTLGIVVGCFVLCWLPFFLVmpigSFFPNFKPPETVF----KIVFWLGYLNSCINPIIYPCSSQEFKKA 336
Cdd:cd15213  194 --------RAFTTILILFIGFSVCWLPYTVY----SLLSVFSRYSSSFyvisTCLLWLSYLKSAFNPVIYCWRIKKFREA 261
7tmA_CB1 cd15340
cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G ...
27-337 4.50e-24

cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320462 [Multi-domain]  Cd Length: 292  Bit Score: 101.52  E-value: 4.50e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGgliIFGVLGNILVILSVACHRHLHSVTHY-YIVNLAVADLLlTSTVLPFSAI-FEILGYWAFGRVFCNIWAA 104
Cdd:cd15340    4 AVLSLTLG---TFTVLENLLVLCVILHSRSLRCRPSYhFIGSLAVADLL-GSVIFVYSFLdFHVFHRKDSPNVFLFKLGG 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 105 VdVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGW---RQQAPEDETICQINEE 181
Cdd:cd15340   80 V-TASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRTKAVIAFCVMWTIAIVIAVLPLLGWnckKLNSVCSDIFPLIDET 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 182 pgYVLfsalgsFYVPLTIILVM---YCRVYVVAKRESRGLKSglktdKSDSEQVTLRIHrknvPAEGSGVSSAK-NKTHF 257
Cdd:cd15340  159 --YLM------FWIGVTSVLLLfivYAYMYILWKAHHHAVRM-----LQRGTQKSIIVY----TSEDGKVQTTRpDQTRM 221
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 258 SVRLlkfsrekkaAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15340  222 DIRL---------AKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAF 292
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
36-337 4.94e-24

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 101.46  E-value: 4.94e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  36 LIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIM 115
Cdd:cd16004   10 IVLVAVTGNATVIWIILAHRRMRTVTNYFIVNLALADLSMAAFNTAFNFVYASHNDWYFGLEFCRFQNFFPITAMFVSIY 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 116 GLCIISIDRYIGVSYPLRYPTIVTQRRGVRALlcVWALSLVISIGPLFGWRQQAPEDETICQIN--EEPG------YVLF 187
Cdd:cd16004   90 SMTAIAADRYMAIIHPFKPRLSAGSTKVVIAG--IWLVALALAFPQCFYSTVTMDQGRTKCIVAwpGDSGgkhqltYHLA 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 188 SALGSFYVPLTIILVMYcrvyvvakresrglksglktdksdsEQVTLRIHRKNVPAEGsgvSSAKNKTHFSVRllkfsre 267
Cdd:cd16004  168 VIVLIYLLPLAVMFVTY-------------------------SIIGITLWRSAVPGHQ---AHGAYHRQLQAK------- 212
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755547671 268 KKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNF---KPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd16004  213 KKFVKTMVVVVVTFAICWLPYHLYFILGSFNEDIycqKYIQQVYLAIFWLAMSSTMYNPIIYCCLNQRFRSGF 285
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
36-326 5.40e-24

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 101.62  E-value: 5.40e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  36 LIIFGVLGNILVILSVACHRHLHSV-THYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASI 114
Cdd:cd15382   10 LFLIAAVGNLTVLLILLRNRRRKRSrVNILLMHLAIADLLVTFIMMPLEIGWAATVAWLAGDFLCRLMLFFRAFGLYLSS 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 115 MGLCIISIDRYIGVSYPLRYPTivTQRRGVRALLCVWALSLVISI----------GPLFGWRQQAPEDETICQINEEPGY 184
Cdd:cd15382   90 FVLVCISLDRYFAILKPLRLSD--ARRRGRIMLAVAWVISFLCSIpqsfifhvesHPCVTWFSQCVTFNFFPSHDHELAY 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 185 VLFSALGSFYVPLTIILVMYCRVYVVAKRESRGLKsglktDKSDSEQVTLRIHRKNVpaegSGVSSAKNKThfsvrlLKF 264
Cdd:cd15382  168 NIFNMITMYALPLIIIVFCYSLILCEISRKSKEKK-----EDVSEKSSSVRLRRSSV----GLLERARSRT------LKM 232
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755547671 265 srekkaakTLGIVVgCFVLCWLPFFlVMPIGSFF---PNFKPPETVFKIVFWLGYLNSCINPIIY 326
Cdd:cd15382  233 --------TIVIVL-VFIICWTPYF-IMSLWYWFdreSASKVDPRIQKGLFLFAVSNSCMNPIVY 287
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
38-337 5.91e-24

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 100.92  E-value: 5.91e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  38 IFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTvLPFSAIFEILGY-WAFGRVFCNIWAAVDVLCCTASIMG 116
Cdd:cd14985   12 LVGLLGNLFVVWVFLFPRGPKRVADIFIANLAAADLVFVLT-LPLWATYTANQYdWPFGAFLCKVSSYVISVNMFASIFL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 117 LCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIgPLFGWRQ-QAPEDETICQINEEP-------GYVLFS 188
Cdd:cd14985   91 LTCMSVDRYLAIVHPVASRRLRRRRQARVTCALIWVVACLLSL-PTFLLRSlQAIENLNKTACIMLYpheawhfGLSLEL 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 189 ALGSFYVPLTIILVMYCRvyvVAKResrglksgLKTDKSDSeqvtlrihRKNVPaegsgvssaknkthfsvrllkfsREK 268
Cdd:cd14985  170 NILGFVLPLLIILTCYFH---IARS--------LRKRYERT--------GKNGR-----------------------KRR 207
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755547671 269 KAAKTLGIVVGCFVLCWLPF----FLVMPIGSFFPNFKPPETV----FKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd14985  208 KSLKIIFALVVAFLVCWLPFhffkFLDFLAQLGAIRPCFWELFldlgLPIATCLAFTNSCLNPFIYVFVDRRFRQKV 284
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
38-335 6.52e-24

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 100.75  E-value: 6.52e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  38 IFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTvLPFSAIfEILGYWAFGRVFCNIWAAVDVLCCTASIMGL 117
Cdd:cd14984   12 LLGLVGNSLVLLVLLYYRKLRSMTDVYLLNLALADLLFVLT-LPFWAV-YAADGWVFGSFLCKLVSALYTINFYSGILFL 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 118 CIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIgPLFGWRQQAPE-DETICQINEEPGYVLF--------S 188
Cdd:cd14984   90 ACISIDRYLAIVHAVSALRARTLLHGKLTCLGVWALALLLSL-PEFIFSQVSEEnGSSICSYDYPEDTATTwktllrllQ 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 189 ALGSFYVPLTIILVMYCRVyvvakresrglksgLKTdksdseqvtlrihrknvpaegsgvssaknkthfsvrLLKFSREK 268
Cdd:cd14984  169 NILGFLLPLLVMLFCYSRI--------------IRT------------------------------------LLRARNHK 198
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755547671 269 K--AAKTLGIVVGCFVLCWLPFFLVMPIGSF-----FPNFKPPETVFKIVFW----LGYLNSCINPIIYPCSSQEFKK 335
Cdd:cd14984  199 KhrALRVIFAVVVVFFLCWLPYNIVLLLDTLqllgiISRSCELSKSLDYALQvtesLAFSHCCLNPVLYAFVGVKFRK 276
7tmA_FPR-like cd15117
N-formyl peptide receptors, member of the class A family of seven-transmembrane G ...
27-337 6.85e-24

N-formyl peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed at elevated levels on polymorphonuclear and mononuclear phagocytes. FPRs bind N-formyl peptides, which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Activation of FPRs by N-formyl peptides such as N-formyl-Met-Leu-Phe (FMLP) triggers a signaling cascade that stimulates neutrophil accumulation, phagocytosis and superoxide production. These responses are mediated through a pertussis toxin-sensitive G(i) protein that activates a PLC-IP3-calcium signaling pathway. While FPRs are involved in host defense responses to bacterial infection, they can also suppress the immune system under certain conditions. Yet, the physiological role of the FPR family is not fully understood.


Pssm-ID: 320245 [Multi-domain]  Cd Length: 288  Bit Score: 100.96  E-value: 6.85e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILsVACHRHLHSVTHYYIVNLAVADLLLTSTvLPFSAIFEILGY-WAFGRVFCNIWAAV 105
Cdd:cd15117    1 ILSLVIYSSAFVLGTLGNGLVIW-VTGFRMTRTVTTVCFLNLAVADFAFCLF-LPFSVVYTALGFhWPFGWFLCKLYSTL 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 106 DVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISiGPLFGWRQQAPEDE-TICQIN----- 179
Cdd:cd15117   79 VVFNLFASVFLLTLISLDRCVSVLWPVWARNHRTPARAALVAVGAWLLALALS-GPHLVFRDTRKENGcTHCYLNfdpwn 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 180 ---EEPGYVL------FSALG------SFYVPLTIILVMYcrvyvvakresrGLksglktdksdseqVTLRIHRKnvpae 244
Cdd:cd15117  158 etaEDPVLWLetvvqrLSAQVitrfvlGFLVPLVIIGGCY------------GL-------------IAARLWRE----- 207
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 245 gsgvssaknkthfsvrllKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIG-SFFPNFKPPETVFKIVFW-----LGYLN 318
Cdd:cd15117  208 ------------------GWVHSSRPFRVLTAVVAAFFLCWFPFHLVSLLElVVILNQKEDLNPLLILLLplsssLACVN 269
                        330
                 ....*....|....*....
gi 755547671 319 SCINPIIYPCSSQEFKKAF 337
Cdd:cd15117  270 SCLNPLLYVFVGRDFRERL 288
7tmA_MCR cd15103
melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
36-337 8.64e-24

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320231 [Multi-domain]  Cd Length: 270  Bit Score: 100.26  E-value: 8.64e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  36 LIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEIL--GYW----AFGRVFCNIWAAVDVLC 109
Cdd:cd15103   10 LGIVSLLENILVILAIAKNKNLHSPMYFFICSLAVADMLVSVSNALETIVIILLnnGYLvprdSFEQHIDNVIDSMICSS 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 110 CTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIgplfgwrqqapedetICQINEEPGYVLFSA 189
Cdd:cd15103   90 LLASICSLLAIAVDRYITIFYALRYHSIMTVRRAGVIITAIWVFCTVCGI---------------LFIIYSDSVPVIICL 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 190 LGSFYVPLTIILVMYCRVYVVAKRESRGLKsglktdksdseqvtlRIHRKNVPAEGSGVssaknkthfsvrllkfsrekK 269
Cdd:cd15103  155 ISMFFAMLVLMASLYVHMFLLARSHVKKIA---------------ALPGQRSTRQRANM--------------------K 199
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755547671 270 AAKTLGIVVGCFVLCWLPFFLVMPIGSFFPnfKPPETV-----FKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15103  200 GAVTLTILLGVFIFCWAPFFLHLTLMISCP--SNPYCAcymshFNVYLILIMCNSVIDPLIYAFRSQELRKTF 270
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
27-337 1.01e-23

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 100.79  E-value: 1.01e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILsVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEIlgYWAFGRVFCNIWAAVD 106
Cdd:cd14978    1 VLYGYVLPVICIFGIIGNILNLV-VLTRKSMRSSTNVYLAALAVSDILVLLSALPLFLLPYI--ADYSSSFLSYFYAYFL 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VL-------CCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIgPLFGWRQqaPEDETICQIN 179
Cdd:cd14978   78 PYiyplantFQTASVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNL-PRFFEYE--VVECENCNNN 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 180 EEPG----------------YVLFSALGSFYVPLTIILVMYCRVYvvakresrglksglktdksdseqVTLRIHRKNVPA 243
Cdd:cd14978  155 SYYYviptllrqnetyllkyYFWLYAIFVVLLPFILLLILNILLI-----------------------RALRKSKKRRRL 211
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 244 EGSGVSSAKNKThfsvrllkfSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPETVFKIV----FwLGYLNS 319
Cdd:cd14978  212 LRRRRRLLSRSQ---------RRERRTTIMLIAVVIVFLICNLPAGILNILEAIFGESFLSPIYQLLGdisnL-LVVLNS 281
                        330
                 ....*....|....*...
gi 755547671 320 CINPIIYPCSSQEFKKAF 337
Cdd:cd14978  282 AVNFIIYCLFSSKFRRTF 299
7tmA_NPY2R cd15399
neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G ...
36-337 1.89e-23

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320521 [Multi-domain]  Cd Length: 285  Bit Score: 99.51  E-value: 1.89e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  36 LIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIM 115
Cdd:cd15399   10 IILLGVVGNSLVIYVVIKFKNMRTVTNFFIANLAVADLMVNTLCLPFTLVYTLLDEWKFGAVLCHLVPYAQALAVHVSTV 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 116 GLCIISIDRYIGVSYPLRypTIVTQRRGVRALLCVWALSLVISiGPLFGWRQ----QAPEDETICQINEE-PG------- 183
Cdd:cd15399   90 TLTVIALDRHRCIVYHLE--SKISKKISFLIIGLTWAASALLA-SPLAIFREysviEISPDFKIQACSEKwPNgtlndgt 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 184 -YVLFSALGSFYVPLTIILVMYCRVYvvakresrglksglktdksdseqVTLRIHrknvpaegsgVSSAKNKTHFSVrll 262
Cdd:cd15399  167 iYSVSMLLIQYVLPLAIISYAYIRIW-----------------------TKLKNH----------VSPGGGNDHYHQ--- 210
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755547671 263 kfsREKKAAKTLGIVVGCFVLCWLPFF---LVMPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15399  211 ---RRRKTTKMLVCVVVVFAVSWLPFHafqLASDIDSKVLDLKEYKLIYTIFHVIAMCSTFANPLLYGWMNNNYRTAF 285
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
33-337 1.91e-23

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 100.61  E-value: 1.91e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  33 LGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGY-WAFGRVFCNIWAAVDVLCCT 111
Cdd:cd15005    7 LGLILCVSLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFPFVMASVRHGSgWIYGALSCKVIAFLAVLFCF 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 112 ASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQAPEDETICQINEEPGYVLFSALG 191
Cdd:cd15005   87 HSAFTLFCIAVTRYMAIAHHRFYAKRMTFWTCLAVICMAWTLSVAMAFPPVFDVGTYTFIREEDQCTFEHRSYKANDTLG 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 192 sFYVPLTIIL----VMYCRVYVVakresrglksglktdksdseqvtLRIHRKNVPAE------------GSGVSS----- 250
Cdd:cd15005  167 -FMLVLAVVIaathLVYLKLLIF-----------------------LRHHRKMKPAQlvpaisqnwtfhGPGATGqaaan 222
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 251 ----------------AKNKTHFSVR----LLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPETVFKI 310
Cdd:cd15005  223 wtagfgrgptpptllgIRQAFHSGARrllvLDEFKMEKRLTRMFYAITLLFLLLWSPYIVACYIRVFVRGYAVPQGFLTA 302
                        330       340
                 ....*....|....*....|....*..
gi 755547671 311 VFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15005  303 AVWMTFAQAGVNPIVCFFFNRELRKCL 329
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
36-336 2.12e-23

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 99.57  E-value: 2.12e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  36 LIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPfsAIFEILGY--WAFGRVFCNIWAAVDVLCCTAS 113
Cdd:cd15131   10 LFVVGVTGNLMTMLVVSKYRDMRTTTNLYLSSMAFSDLLIFLCMPL--DLYRLWQYrpWNFGDLLCKLFQFVSESCTYST 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 114 IMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLvISIGPLF---GWRQQA---PEDETICQINE---EPGY 184
Cdd:cd15131   88 ILNITALSVERYFAICFPLRAKVVVTKRRVKLVILVLWAVSF-LSAGPIFvlvGVEHENgtnPIDTNECKATEyavRSGL 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 185 VLFSALGS---FYVPLTIILVMYcrvyvvakresrglksglktdksdsEQVTLRIHRKNVPAEGSGVsSAKNKTHfsvrl 261
Cdd:cd15131  167 LTIMVWVSsvfFFLPVFCLTVLY-------------------------SLIGRKLWRRRRENIGPNA-SHRDKNN----- 215
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 262 lkfsreKKAAKTLGIVVGCFVLCWLPFFLVMPIgsFFPNFKPPETVFKIV--------FWLGYLNSCINPIIYPCSSQEF 333
Cdd:cd15131  216 ------RQTVKMLAVVVFAFVLCWLPFHVGRYL--FSKSFEAGSLEIALIsqycnlvsFVLFYLSAAINPILYNIMSKKY 287

                 ...
gi 755547671 334 KKA 336
Cdd:cd15131  288 RVA 290
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
28-336 7.02e-23

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 97.89  E-value: 7.02e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  28 LLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDV 107
Cdd:cd15073    2 IVAAYLIVAGIISTISNGIVLVTFVKFRELRTPTNALIINLAVTDLGVSIIGYPFSAASDLHGSWKFGYAGCQWYAFLNI 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 108 LCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLcVWALSLVISIGPLFGWRQQAPEDE-TICQINEEPGYVL 186
Cdd:cd15073   82 FFGMASIGLLTVVAVDRYLTICRPDLGRKMTTNTYTVMILL-AWTNAFFWAAMPLVGWASYALDPTgATCTINWRKNDSS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 187 F-------SALGsFYVPLTIILVMYCRVYVVAKRESRG-LKSGLKTDKSDSEQVTlrihrknvpaegsgvssaknkthfs 258
Cdd:cd15073  161 FvsytmsvIVVN-FIVPLAVMFYCYYNVSRFVKKVLASdCLESVNIDWTDQNDVT------------------------- 214
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755547671 259 vrllkfsrekkaaKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKA 336
Cdd:cd15073  215 -------------KMSVIMIVMFLVAWSPYSIVCLWASFGEPKKIPPWMAIIPPLFAKSSTFYNPCIYVIANKKFRRA 279
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
36-337 7.48e-23

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 98.37  E-value: 7.48e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  36 LIIF--GVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLltstVLPFSAIFEILGYWA-----FGRVFCNIWAAVDVL 108
Cdd:cd15133    8 LLIFvvGVVGNVLTCLVIARHKAMRTPTNYYLFSLAVSDLL----VLLLGMPLELYELWQnypflLGSGGCYFKTFLFET 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 109 CCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISI------GPLFgwRQQAPEDETICQInEEP 182
Cdd:cd15133   84 VCLASILNVTALSVERYIAVVHPLAARTCSTRPRVTRVLGCVWGVSMLCALpntslhGIKF--LGSGVPASAQCTV-RKP 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 183 GYVL-----FSALGSFYVPLTIILVMYCRVYVVAKREsRGLKSGLKTDKSDSEQVTLRIHRKnvpaegsgvssaknkthf 257
Cdd:cd15133  161 QAIYnmipqHTGHLFFVLPMAVISVLYLLMALRLARE-RGLDATGAGSKIGTRTGQLLQHPR------------------ 221
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 258 svrllkfsREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPP-ETVFKIVF----WLGYLNSCINPIIYPCSSQE 332
Cdd:cd15133  222 --------TRAQVTKMLFILVVVFAICWAPFHIDRLMWSFISDWTDNlHEVFQYVHiisgVFFYLSSAVNPILYNLMSTR 293

                 ....*
gi 755547671 333 FKKAF 337
Cdd:cd15133  294 FREMF 298
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
31-337 1.74e-22

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 97.11  E-value: 1.74e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  31 VILGGLIIF--GVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVL 108
Cdd:cd14977    3 IMSLSLVIFavGIIGNLMVLCIVCTNYYMRSVPNILIASLALGDLLLLLLCVPLNAYNLLTKDWLFGDVMCKLVPFIQVT 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 109 CCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGW--RQQAPEDE---TICQINEEPG 183
Cdd:cd14977   83 SLGVTVFSLCALSIDRYRAAVNSMPMQTIGACLSTCVKLAVIWVGSVLLAVPEAVLStvARESSLDNsslTVCIMKPSTP 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 184 YVLFSA------LGSFY--VPLTIILVMYCrvyVVAKRESRglkSGLKTDKSDSEQVTLRihrknvpaegsgvssaknkt 255
Cdd:cd14977  163 FAETYPkarswwLFGCYfcLPLAFTAVCYL---LMARTLIR---AAKEYTRGTKKHMKQR-------------------- 216
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 256 hfsvrllkfsreKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPET------VFKIVFWLGYLNSCINPIIYPCS 329
Cdd:cd14977  217 ------------RQLAKTVLCLVLVFAFCWLPEHISNILRATLYNEVLIDTrstldiLDLIGQFLSFFNSCVNPIALYLL 284

                 ....*...
gi 755547671 330 SQEFKKAF 337
Cdd:cd14977  285 SEPFRRAF 292
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
43-336 2.88e-22

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 95.97  E-value: 2.88e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  43 GNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISI 122
Cdd:cd15012   16 GNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCVLQNLSIYLIPSWPFGEVLCRMYQFVHSLSYTASIGILVVISV 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 123 DRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIgPLFGWRQQAP---EDET--------ICQINEEPGYVLFSALG 191
Cdd:cd15012   96 ERYIAILHPLRCKQLLTAARLRVTIVTVWLTSAVYNT-PYFVFSQTVEilvTQDGqeeeicvlDREMFNSKLYDTINFIV 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 192 SFYVPLTIILVMYCRVYVVAKRESRGLKsglktdksdseqvtlrihRKNVpaegsgvssaknkthfsVRLLKfsrekkaa 271
Cdd:cd15012  175 WYLIPLLIMTVLYSKISIVLWKSSSIEA------------------RRKV-----------------VRLLV-------- 211
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755547671 272 ktlgIVVGCFVLCWLPFFLVMPIGSF------FPNFKPPETVfkIVFWLGYLNSCINPIIYPCSSQEFKKA 336
Cdd:cd15012  212 ----AVVVSFALCNLPYHARKMWQYWsepyrcDSNWNALLTP--LTFLVLYFNSAVNPLLYAFLSKRFRQS 276
7tmA_MC4R cd15353
melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G ...
31-337 4.81e-22

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320475 [Multi-domain]  Cd Length: 269  Bit Score: 95.36  E-value: 4.81e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  31 VILGgliIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGR--VFCNIWAAVDVL 108
Cdd:cd15353    8 VTLG---IVSLLENILVIAAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETVVITLLNGNDTDAqsFTVNIDNVIDSV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 109 CCT---ASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVisIGPLFgwrqqapedeticQINEEPGYV 185
Cdd:cd15353   85 ICSsllASICSLLSIAVDRYFTIFYALQYHNIMTVRRAGVIITCIWTACTV--SGVLF-------------IIYSDSSVV 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 186 LFSALGSFYVPLTIILVMYCRVYVVAkresrglksglktdksdseqvtlRIHRKNVpAEGSGVSSAKNKTHFsvrllkfs 265
Cdd:cd15353  150 IICLISMFFTMLALMASLYVHMFLLA-----------------------RLHIKRI-AVLPGTGPIRQGANM-------- 197
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755547671 266 rekKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPnfKPPETV-----FKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15353  198 ---KGAITLTILLGVFVVCWAPFFLHLIFYISCP--RNPYCVcfmshFNMYLILIMCNSVIDPLIYAFRSQELRKTF 269
7tmA_BNGR-A34-like cd15000
putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...
36-337 7.24e-22

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320131 [Multi-domain]  Cd Length: 285  Bit Score: 95.18  E-value: 7.24e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  36 LIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIM 115
Cdd:cd15000    9 VVLFGIFGNFVLLYILASNRSLRTPTNLLIGNMALADLLTLLVCPWMFLVHDFFQNYVLGSVGCKLEGFLEGSLLLASVL 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 116 GLCIISIDRYIGVSYPLRypTIVTQRRGVRALLCVW----ALSLVISIGPLFGWRQQAPEDETIC----QINEEPGYVLF 187
Cdd:cd15000   89 ALCAVSYDRLTAIVLPSE--ARLTKRGAKIVIVITWivglLLALPLAIYRSYRERQWKNFLETYCaentQVLPIYWHVII 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 188 SALgsFYVPLTIILVMYCRVYvvakresrglksgLKTDKsdSEQVTLRihrknvpAEGSGVSSAKnkthfsvrllkfsre 267
Cdd:cd15000  167 TVL--VWLPLGIMLICYSAIF-------------WKLDK--YERRVLR-------REHPSVVRYK--------------- 207
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755547671 268 KKAAKTLGIVVGCFVLCWLPF-FLVMPIGSFFPNFKPPETV--FKIVFW-----LGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15000  208 KKAAKTLFIVLITFVVCRIPFtALIFYRYKLVPNDNTQNSVsgSFHILWfaskyLMFLNAAVNPLIYGFTNENFRKAF 285
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
32-337 8.05e-22

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 95.00  E-value: 8.05e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  32 ILGGLIIFGvlgNILVILSVACHRHL-HSVTHYYIVNLAVADLLL-------TSTVLPFSAIFEILGYWAFGRVFCNIwa 103
Cdd:cd14980    9 IIGILALIG---NILVIIWHISSKKKkKKVPKLLIINLAIADFLMgiylliiAIADQYYRGRYAQYSEEWLRSPPCLL-- 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 104 aVDVLCCTASIMG---LCIISIDRYIGVSYPLRYPTIvTQRRGVRALLCVWALSLVISIGPLFGWRQQAPEDE-----TI 175
Cdd:cd14980   84 -ACFLVSLSSLMSvlmMLLITLDRYICIVYPFSNKRL-SYKSAKIILILGWLFSIIFAAIPILYSINQPGDNRlygysSI 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 176 C-QINEEPGYVLFSALgsFYVPLT-----IILVMYCRVYVVAKRESRglksglktdksdseqvtlrihrknvpaegsgvs 249
Cdd:cd14980  162 CmPSNVSNPYYRGWLI--AYLLLTfiawiIICILYILIFISVRKSRK--------------------------------- 206
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 250 saknkthfSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPETV-FKIVFWLGyLNSCINPIIYPC 328
Cdd:cd14980  207 --------SARRSSSKRDKRIAIRLALILITDLICWLPYYIVIFSGLLTSTEIDIHVLqFIAILALP-LNSAINPYLYTL 277

                 ....*....
gi 755547671 329 SSQEFKKAF 337
Cdd:cd14980  278 TTPTFKRDF 286
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
27-337 1.43e-21

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 94.12  E-value: 1.43e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHL-HSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAV 105
Cdd:cd15097    1 VIVPVVFSLIFLLGTVGNSLVLAVLLRSGQSgHNTTNLFILNLSVADLCFILFCVPFQATIYSLEGWVFGSFLCKAVHFF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 106 DVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQAPEDETICQ--INEEPG 183
Cdd:cd15097   81 IYLTMYASSFTLAAVSVDRYLAIRYPLRSRELRTPRNAVAAIALIWGLSLLFAGPYLSYYDLIDYANSTVCMpgWEEARR 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 184 YVLFSA--LGSFYVPLTIILVMYCRvyvvakresrglksglktdksdseqvTLRIHRKNVPAEGSGVSSAKNKthfsvrl 261
Cdd:cd15097  161 KAMDTCtfAFGYLIPVLVVSLSYTR--------------------------TIKYLWTAVDPLEAMSESKRAK------- 207
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755547671 262 lkfsreKKAAKTLGIVVGCFVLCWLPFFLVMPIGSF--FPnFKPPETVFKIV-FWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15097  208 ------RKVTKMIIIVTALFCLCWLPHHVVILCYLYgdFP-FNQATYAFRLLsHCMAYANSCLNPIVYALVSKHFRKGF 279
7tmA_NPFFR2 cd15980
neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G ...
32-337 2.49e-21

neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320646 [Multi-domain]  Cd Length: 299  Bit Score: 93.80  E-value: 2.49e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  32 ILGGLIIFGV--LGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLC 109
Cdd:cd15980    4 IASYLLIFLLcmMGNGVVCFIVLRSKHMRTVTNLFILNLAISDLLVGIFCMPTTLLDNIIAGWPFGSTVCKMSGMVQGIS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 110 CTASIMGLCIISIDRYIGVSYPLRYPtiVTQRRGVRALLCVWALSLVI------------------------SIGPLFGW 165
Cdd:cd15980   84 VSASVFTLVAIAVDRFRCIVYPFKQK--LTISTAVVIIVIIWVLAIAImcpsavmlhvqeeknyrvvlgsqnKTSPVYWC 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 166 RQQAPEDEticqINEEPGYVLFSALgsFYVPLTIILVMYCRVYVVakresrglksglktdksdseqvtlrIHRKNVPAEG 245
Cdd:cd15980  162 REDWPNQE----MRKIYTTVLFANI--YLAPLSLIVIMYARIGIT-------------------------LFKTAMPHTG 210
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 246 sgvssaknKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIgSFFPNFKPPET------VFKIVFWLGYLNS 319
Cdd:cd15980  211 --------KHNQEQRHVVSRKKQKVIKMLLIVALLFILSWLPLWTLMML-SDYANLSPNQLqiiniyIYPFAHWLAFFNS 281
                        330
                 ....*....|....*...
gi 755547671 320 CINPIIYPCSSQEFKKAF 337
Cdd:cd15980  282 SVNPIIYGFFNENFRRGF 299
7tmA_AT2R cd15191
type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
38-326 6.51e-21

type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 341341 [Multi-domain]  Cd Length: 285  Bit Score: 92.51  E-value: 6.51e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  38 IFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTvLPFSAIFEILGY-WAFGRVFCNIWAAVDVLCCTASIMG 116
Cdd:cd15191   12 ILGFLGNSLVVCVFCHQSGPKTVASIYIFNLAVADLLFLAT-LPLWATYYSYGYnWLFGSVMCKICGSLLTLNLFASIFF 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 117 LCIISIDRYIGVSYPLRyptivTQRRGVRALLC----VWALSLVISIgPLFGWRQQAPEDE---TICQI---NEEP---- 182
Cdd:cd15191   91 ITCMSVDRYLAVVYPLR-----SQRRRSWQARLvcllVWVLACLSSL-PTFYFRDTYYIEElgvNACIMafpNEKYaqws 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 183 -GYVLFSALGSFYVPLTIILVMYCRVyvvakresrglksglktdksdseqvtlRIHRKNVPAEGsgvssaKNKthfsvrl 261
Cdd:cd15191  165 aGLALMKNTLGFLIPLIVIATCYFGI---------------------------GRHLLKTKGFG------KNK------- 204
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755547671 262 lkfSREKKAAKTLGIVVGCFVLCWLPFFLV--------MPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIY 326
Cdd:cd15191  205 ---QRRDKVLKMVAAVVLAFLICWFPFHVLtfldalarMGVINNCWVITVIDKALPFAICLGFSNSCINPFLY 274
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
26-337 8.91e-21

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 91.68  E-value: 8.91e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  26 AILLGVILGGLiifGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLL-LTSTVLP-FSAIFEILGYWAFGRVFCNIWA 103
Cdd:cd14995    3 ATFLVLLICGV---GIVGNIMVVLVVLRTRHMRTPTNCYLVSLAVADLMvLVAAGLPnEIESLLGPDSWIYGYAGCLLIT 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 104 AVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLF--GWRQQAPEDETICQInee 181
Cdd:cd14995   80 YLQYLGINASSLSITAFTIERYIAICHPMKAQFICTVSRAKKIICFVWIFTSLYCSPWLFllDLSIKHYGDDIVVRC--- 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 182 pGY---------VLFSALGSFYV-PLTIILVMYCRVyvvakresrglksglktdksdseqvtlrihrknvpaegsgvssa 251
Cdd:cd14995  157 -GYkvsrhyylpIYLADFVLFYViPLLLAIVLYGLI-------------------------------------------- 191
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 252 knkthfsVRLLkFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFF-PNFKPPETVF--KIVFwlgYLNSCINPIIYPC 328
Cdd:cd14995  192 -------GRIL-FSSRKQVTKMLAVVVVLFALLWMPYRTLVVYNSFAsPPYLDLWFLLfcRTCI---YLNSAINPILYNL 260

                 ....*....
gi 755547671 329 SSQEFKKAF 337
Cdd:cd14995  261 MSQKFRAAF 269
7tmA_GPR61_GPR62-like cd15220
G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G ...
41-328 9.44e-21

G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the orphan receptors GPR61 and GPR62, which are both constitutively active and predominantly expressed in the brain. While GPR61 couples to G(s) subtype of G proteins, the signaling pathway and function of GPR 62 are unknown. GPR61-deficient mice displayed significant hyperphagia and heavier body weight compared to wild-type mice, suggesting that GPR61 is involved in the regulation of food intake and body weight. GPR61 transcript expression was found in the caudate, putamen, and thalamus of human brain, whereas GPR62 transcript expression was found in the basal forebrain, frontal cortex, caudate, putamen, thalamus, and hippocampus. Both receptors share the highest sequence homology with each other and comprise a conserved subgroup within the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. Members of this subgroup contain [A/E]RY motif, a variant of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the class A GPCRs and important for efficient G protein-coupled signal transduction.


Pssm-ID: 410633 [Multi-domain]  Cd Length: 264  Bit Score: 91.36  E-value: 9.44e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  41 VLGNILVILSVACHRHLHS---VTHYYIVNLAVADLLLTSTVLPFSAIFEILGywaFGRVFCNIWAAVDVLCCTASIMGL 117
Cdd:cd15220   14 LVGNTAVMVVIAKTPHLRKfafVCHLCVVDLLAALLLMPLGILSSSPFFLGVV---FGEAECRVYIFLSVCLVSASILTI 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 118 CIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGW---RQQAPEDETICQINEEPG-----YVLFSA 189
Cdd:cd15220   91 SAISVERYYYIVHPMRYEVKMTIGLVAAVLVGVWVKALLLGLLPVLGWpsyGGPAPIAARHCSLHWSHSghrgvFVVLFA 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 190 LGSFYVPLTIILVMYCRVYVVAkresrglksglktdksdseqvtlrihrknvpaeGSGvssaknkthfsvrllkfsrekK 269
Cdd:cd15220  171 LVCFLLPLLLILVVYCGVFKVF---------------------------------GGG---------------------K 196
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 755547671 270 AAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIYPC 328
Cdd:cd15220  197 AALTLAAIVGQFLCCWLPYFAFHLYSALAASPVSGGEAEEVVTWLAYSCFAVNPFFYGL 255
7tmA_CMKLR1 cd15116
chemokine-like receptor 1, member of the class A family of seven-transmembrane G ...
27-337 1.45e-20

chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine receptor-like 1 (also known as Chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. CMKLR1 is prominently expressed in dendritic cells and macrophages.


Pssm-ID: 320244 [Multi-domain]  Cd Length: 284  Bit Score: 91.36  E-value: 1.45e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILsVACHRHLHSVTHYYIVNLAVADLLLTsTVLPFSAIFEILGY-WAFGRVFCNIWAAV 105
Cdd:cd15116    1 ILSMVIYSVVFVLGVLGNGLVIF-ITGFKMKKTVNTVWFLNLAVADFLFT-FFLPFSIAYTAMDFhWPFGRFMCKLNSFL 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 106 DVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIgPLFGWRQQAP---EDETICQIN--- 179
Cdd:cd15116   79 LFLNMFTSVFLLTVISIDRCISVVFPVWSQNHRSVRLASLVSLAVWVVAFFLSS-PSFIFRDTAPsqnNNKIICFNNfsl 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 180 ---------------EEPGYVLFSALGSFYVPLTIILVMYCRVYVVAKREsrglksglktdksdseqvtlrihrknvpae 244
Cdd:cd15116  158 sgdnsspevnqlrnmRHQVMTITRFLLGFLIPFTIIICCYAAIVLKLKRN------------------------------ 207
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 245 gsgvssaknkthfsvrllKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFfpNFKPPETVFK----IVFWLGYLNSC 320
Cdd:cd15116  208 ------------------RLAKSSKPFKIIAAVIVTFFLCWAPYHILNLLEME--ATRSPASVFKiglpITSSLAFINSC 267
                        330
                 ....*....|....*..
gi 755547671 321 INPIIYPCSSQEFKKAF 337
Cdd:cd15116  268 LNPILYVFMGQDFKKFK 284
7tmA_Mel1A cd15402
melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
29-337 1.48e-20

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320524 [Multi-domain]  Cd Length: 279  Bit Score: 91.12  E-value: 1.48e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  29 LGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVL 108
Cdd:cd15402    3 LACILIFTIVVDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLTSIFHNGWNLGYLHCQISGFLMGL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 109 CCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQAPEDETICQINE--EPGYVL 186
Cdd:cd15402   83 SVIGSIFNITGIAINRYCYICHSLKYDKLYSDKNSLCYVLLIWVLTVAAIVPNLFVGSLQYDPRIYSCTFAQsvSSAYTI 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 187 FSALGSFYVPLTIILVMYCRVYVVAKresrglksglktdksdseQVTLRIHRKNVPaegsgvssaKNKTHfsvrllkfsr 266
Cdd:cd15402  163 AVVFFHFILPIIIVTFCYLRIWILVI------------------QVRRRVKPDNKP---------KLKPH---------- 205
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755547671 267 EKKAAKTLGIVVGCFVLCWLPF-FLVMPIGSFFPNFKP--PETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15402  206 DFRNFVTMFVVFVLFAVCWAPLnFIGLAVAVDPETIVPriPEWLFVASYYMAYFNSCLNAIIYGLLNQNFRREY 279
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
36-326 1.60e-20

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 91.15  E-value: 1.60e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  36 LIIFGVLGNILVILSVACHRHLHSVTHYY--IVNLAVADLLLTSTVLPFSAIFEILGY-WAFGRVFCNIWAAVDVLCCTA 112
Cdd:cd14981   10 MFVFGVLGNLLALIVLARSSKSHKWSVFYrlVAGLAITDLLGILLTSPVVLAVYASNFeWDGGQPLCDYFGFMMSFFGLS 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 113 SIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFG---WRQQAPEdeTICQIN---EEPGYVL 186
Cdd:cd14981   90 SLLIVCAMAVERFLAITHPFFYNSHVKKRRARLMLGAVWAFALLIASLPLLGlgsYVLQYPG--TWCFLDfysKNTGDAA 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 187 FSALGSFYVPLTIILVMYCRVYVVAKresrglksglktdksdseqvTLRIHRKNVPAEGSGVSSAKNKTH--FSVRLLkf 264
Cdd:cd14981  168 YAYLYSILGLLILLVTLLCNLLVIIT--------------------LLRMRRRKKRHRRSRRSARRQKRNeiQMVVLL-- 225
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755547671 265 srekkaaktLGIVVgCFVLCWLPFF---LVMPIGSFFPNFKPPETVFKIVFWlgylNSCINPIIY 326
Cdd:cd14981  226 ---------LAITV-VFSVCWLPLMirvLINATGDSEKNGKTDLLAVRMASW----NQILDPWVY 276
7tmA_Cannabinoid_R cd15099
cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled ...
39-337 2.12e-20

cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320227 [Multi-domain]  Cd Length: 281  Bit Score: 91.05  E-value: 2.12e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  39 FGVLGNILVILSVACHRHLHSVTHY-YIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVdVLCCTASIMGL 117
Cdd:cd15099   13 VTFLENILVLLTILSSTALRRRPSYlFIGSLALADMLASVIFTISFLDFHVFHQRDSRNLFLFKLGGV-TMAFTASVGSL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 118 CIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWR---QQAPEDETICQINEEpgyVLFSALGSFY 194
Cdd:cd15099   92 LLTALDRYLCIYQPSNYKLLVTRTRAKVAILLMWCVTIIISFLPLMGWRcktWDSPCSRLFPYIDRH---YLASWTGLQL 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 195 VPLTIILVMYcrVYVVAKRESrglksglktdksdseqvtlriHRKNVPAEGSGVSSAK--NKTHFSVRLlkfsrekkaAK 272
Cdd:cd15099  169 VLLFLIIYAY--PYILWKAHR---------------------HEANMGGPKLGRQQVKgqARMRMDIRL---------AK 216
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755547671 273 TLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15099  217 TLSLILLVLAICWLPVLAFMLVDVRVTLTNKQKRMFAFCSMLCLVNSCVNPIIYALRSRELRGAM 281
7tmA_EBI2 cd15159
Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G ...
27-335 2.25e-20

Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2), also called GPR183, is activated by 7alpha, 25-dihydroxyxcholesterol (7alpha, 25-OHC), an oxysterol. EBI2 was originally identified as one of major genes induced in the Burkitt's lymphoma cell line BL41by EBV infection. EBI2 is involved in regulating B cell migration and responses, and is also implicated in human diseases such as type I diabetes, multiple sclerosis, and cancers.


Pssm-ID: 320287 [Multi-domain]  Cd Length: 286  Bit Score: 90.87  E-value: 2.25e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTsTVLPFSAIFEILGY-WAFGRVFCNIWAAV 105
Cdd:cd15159    1 VLLPLFYSLILVFGLLGNTLALHVICQKRKKINSTTLYLINLAVSDILFT-LALPGRIAYYALGFdWPFGDWLCRLTALL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 106 DVLCCTASIMGLCIISIDRYIGVSYPLRYPTIvtQRRGVRALLC--VWALSLVISIGPLFGWRQQAPEDETIC------- 176
Cdd:cd15159   80 FYINTYAGVNFMTCLSVDRYIAVVHPLRRHRL--RKVKVVRYICvfVWVLVFLQTLPLLFMPMTKEMGGRITCmeypnfe 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 177 QINEEPGYVLFSALGSFYVPLTIILVMY----CRVYVVAKRESRGLKSGlktdksdseqvtlrihrknvpaegsgvssak 252
Cdd:cd15159  158 KIKRLPLILLGACVIGFGVPVGIILFCYsqitLKLCRTAKENPLTEKSG------------------------------- 206
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 253 nkthfsvrllkfsREKKAAKTLGIVVGCFVLCWLPF------FLVMPIgsFFPNFKPPETVFKI-----VFWLGyLNSCI 321
Cdd:cd15159  207 -------------HHKKACNVILLVLLVFVVCFSPYhlniiqFMIRKL--LYQPSCSELKAFKIslqitVCLMN-LNCCL 270
                        330
                 ....*....|....
gi 755547671 322 NPIIYPCSSQEFKK 335
Cdd:cd15159  271 DPFIYFFACKGYKK 284
7tmA_NPY4R cd15397
neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G ...
36-335 2.78e-20

neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320519 [Multi-domain]  Cd Length: 293  Bit Score: 90.57  E-value: 2.78e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  36 LIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIM 115
Cdd:cd15397   10 VMAVGLLGNICLICVIARQKEKTNVTNILIANLSFSDILVCLVCLPFTVVYTLMDYWIFGEVLCKMTPFIQCMSVTVSIL 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 116 GLCIISIDRYIGVSYPLRYPTIVTQrrGVRALLCVWALSLVISIgPLFGWRQQAPE-------------DETIC-----Q 177
Cdd:cd15397   90 SLVLIALERHQLIINPTGWKPSVSQ--AYLAVVVIWMLACFISL-PFLAFHILTDEpyknlshffaplaDKAVCteswpS 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 178 INEEPGYVLFSALGSFYVPLTIILVMYCRVYvvakresrglksglktdksdseqvtLRIHRKNVPAEGSGVSSAKNKTHF 257
Cdd:cd15397  167 EHHKLAYTTWLLLFQYCLPLLFILVCYLRIY-------------------------LRLRRRKDMLERRGEYNRRAGHSK 221
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 258 SVRLLkfsrekkaaktLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPP---ETVFKIVFWLGYLNSCINPIIYPCSSQEFK 334
Cdd:cd15397  222 RINVM-----------LVSLVAAFALCWLPLNVFNAIADWNHEAIPHcqhNLIFSLCHLAAMASTCVNPIIYGFLNSNFK 290

                 .
gi 755547671 335 K 335
Cdd:cd15397  291 K 291
7tmA_NMU-R1 cd15358
neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G ...
36-337 4.49e-20

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320480 [Multi-domain]  Cd Length: 305  Bit Score: 90.21  E-value: 4.49e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  36 LIIF--GVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSaIFEILGYWAF--GRVFCNIWAAVDVLCCT 111
Cdd:cd15358    8 LLIFvvGAVGNGLTCIVILRHKVMRTPTNYYLFSLAVSDLLVLLLGMPLE-LYEMWSNYPFllGAGGCYFKTLLFETVCF 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 112 ASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIG----------PLFGwRQQAPEDETICQINEE 181
Cdd:cd15358   87 ASILNVTALSVERYIAVVHPLKAKYVVTRTHAKRVIGAVWVVSILCSIPntslhgifqlTVPC-RGPVPDSATCMLVKPR 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 182 PGY---VLFSALGSFYVPLTIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNVpaegsgvssaknkthfs 258
Cdd:cd15358  166 WMYnliIQITTLLFFFLPMGTISVLYLLIGLQLKREKMLLVLEAKGSKAGDSYQHRRIQQEKR----------------- 228
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 259 vrllkfsREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPP-----ETVFKIVFWLGYLNSCINPIIYPCSSQEF 333
Cdd:cd15358  229 -------RRRQVTKMLFVLVVVFGICWAPFHTDRLMWSFISQWTGElhlafQYVHIISGVFFYLSSAANPVLYNLMSTRF 301

                 ....
gi 755547671 334 KKAF 337
Cdd:cd15358  302 REMF 305
7tmA_GPR25 cd15193
G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...
38-335 5.02e-20

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.


Pssm-ID: 320321 [Multi-domain]  Cd Length: 279  Bit Score: 89.81  E-value: 5.02e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  38 IFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTvLPFSAIFEILGY-WAFGRVFCNIWAAVDVLCCTASIMG 116
Cdd:cd15193   12 FTGLLGNLFVIALMSKRSTTKRLVDTFVLNLAVADLVFVLT-LPFWAASTALGGqWLFGEGLCKLSSFIIAVNRCSSILF 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 117 LCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQapeDETICQINEEP----GYVLFSALGS 192
Cdd:cd15193   91 LTGMSVDRYLAVVKLLDSRPLRTRRCALITCCIIWAVSLVLGIPSLVYRNLI---NESVCVEDSSSrffqGISLATLFLT 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 193 FYVPLTIILVMYCRVYVVAKResrglksglktdksdseqvtlrihrknvpaegsgvssaknktHFSVRLLKFSREKKAAK 272
Cdd:cd15193  168 FVLPLIVILFCYCSILVRLRR------------------------------------------HFHGAKRTGRRRRNSLR 205
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755547671 273 TLGIVVGCFVLCWLPF------FLVMPIGSFFPNfkPPETV-----FKIVFWLGYLNSCINPIIYPCSSQEFKK 335
Cdd:cd15193  206 IVFAIVTAFVLSWLPFntlkavRLLLELGGGVLP--CHTTVairqgLTITACLAFVNSCVNPLIYSLLDRHFRR 277
7tmA_MC5R cd15354
melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...
36-337 5.15e-20

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320476 [Multi-domain]  Cd Length: 270  Bit Score: 89.61  E-value: 5.15e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  36 LIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLT------STVLPFSAIFEILGYWAFGRVFCNIWAAVDVLC 109
Cdd:cd15354   10 LGIISLLENILVILAIVKNKNLHSPMYFFVCSLAVADMLVSvsnaweTITIYLLNNRHLVIEDAFVRHIDNVFDSLICIS 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 110 CTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIgplfgwrqqapedetICQINEEPGYVLFSA 189
Cdd:cd15354   90 VVASMCSLLAIAVDRYVTIFYALRYHNIMTVRRAGIIIACIWTFCTGCGI---------------IFILYSESTYVIICL 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 190 LGSFYVPLTIILVMYCRVYVVAkresrglksglktdksdseqvtlRIHRKNVPAEgSGVSSAKNKTHFsvrllkfsrekK 269
Cdd:cd15354  155 ITMFFAMLFLMVSLYIHMFLLA-----------------------RTHVKRIAAL-PGYNSVRQRTSM-----------K 199
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755547671 270 AAKTLGIVVGCFVLCWLPFFLVM------PIGSFFPNFKppeTVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15354  200 GAVTLTILLGIFIVCWAPFFLHLilmiscPQNLYCVCFM---SHFNMYLILIMCNSVIDPLIYAFRSQEMRKTF 270
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
27-337 7.20e-20

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 89.30  E-value: 7.20e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTvLPFSAIFEILG-YWAFGRVFCNIWAAV 105
Cdd:cd15168    1 IFLPIVYGVVFLVGLLLNSVVLYRFIFHLKPWNSSAIYMFNLAVSDLLYLLS-LPFLIYYYANGdHWIFGDFMCKLVRFL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 106 DVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQAPEDETIC---QINEE- 181
Cdd:cd15168   80 FYFNLYGSILFLTCISVHRYLGICHPLRSLGKLKKRHAVAISVAVWILVLLQLLPILFFATTGRKNNRTTCydtTSPEEl 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 182 PGYVLFS---ALGSFYVPLTIILVMYCRvyvvakresrglksglktdksdseqVTLRIHRKNvpaeGSGVSSAknkthfs 258
Cdd:cd15168  160 NDYVIYSmvlTGLGFLLPLLIILACYGL-------------------------IVRALIRKL----GEGVTSA------- 203
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 259 vrllkfsREKKAAKTLGIVVGCFVLCWLPF------FLVMPIGSFFPN---FKPPETVFKIVFWLGYLNSCINPIIYPCS 329
Cdd:cd15168  204 -------LRRKSIRLVIIVLALFAVCFLPFhvtrtiNLAARLLSGTAScatLNGIYVAYKVTRPLASLNSCLNPLLYFLA 276

                 ....*...
gi 755547671 330 SQEFKKAF 337
Cdd:cd15168  277 GDKFRRRL 284
7tmA_NPFFR1 cd15981
neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G ...
31-337 1.15e-19

neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320647 [Multi-domain]  Cd Length: 299  Bit Score: 89.11  E-value: 1.15e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  31 VILGGLIIF--GVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVL 108
Cdd:cd15981    3 FILAYLFIFllCMVGNGLVCFIVLKNRQMRTVTNMFILNLAVSDLLVGIFCMPTTLVDNLITGWPFDNAMCKMSGLVQGM 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 109 CCTASIMGLCIISIDRYIGVSYPLRYPtiVTQRRGVRALLCVWALSLVI-----------------------SIGPLFGW 165
Cdd:cd15981   83 SVSASVFTLVAIAVERFRCIVHPFRQK--LTLRKAIVTIVIIWVLALIImcpsavtltvtreehhfmvddynNSYPLYSC 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 166 RQQAPEDEticqINEEPGYVLFSALgsFYVPLTIILVMYCRVyvvakresrglksglktdksdseqvTLRIHRKNVPAEG 245
Cdd:cd15981  161 WEAWPDTE----MRKIYTTVLFSHI--YLAPLTLIVIMYARI-------------------------AFKLFKSSAPIRG 209
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 246 SGVSSAKNKthfsvrllKFSREK-KAAKTLGIVVGCFVLCWLPFFLVMPIGSFfPNFKPPET------VFKIVFWLGYLN 318
Cdd:cd15981  210 SQGEEEEGR--------RVSKRKiKVINMLIIVALFFTLSWLPLWTLMLLTDY-GHLSEDQLnlvtvyVFPFAHWLAFFN 280
                        330
                 ....*....|....*....
gi 755547671 319 SCINPIIYPCSSQEFKKAF 337
Cdd:cd15981  281 SSVNPIIYGYFNENFRRGF 299
7tmA_V2R cd15388
vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
32-326 1.64e-19

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320510 [Multi-domain]  Cd Length: 295  Bit Score: 88.68  E-value: 1.64e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  32 ILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLT-STVLPfSAIFEILGYWAFGRVFCNIWAAVDVLCC 110
Cdd:cd15388    6 VLAIIFACALLSNSLVLLVLWRRRKQLARMHVFMLHLCIADLVVAfFQVLP-QLVWDITDRFRGPDVLCRLVKYLQVVGM 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 111 TASIMGLCIISIDRYIGVSYPLryptiVTQRRGV----RALLCVWALSLVISIGPLFGWRQQAPEDETI-CQIN-EEP-- 182
Cdd:cd15388   85 FASSYMIVAMTFDRHQAICRPM-----VTFQKGRarwnGPVCVAWAISLILSLPQVFIFSKVEVAPGVYeCWACfIEPwg 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 183 --GYVLFSALGSFYVPLTIILVmyCRVyvvakRESRGLKSGLKTDKSDSEQVTLRIHRKN-VPAEGSGVSSAKNKThfsV 259
Cdd:cd15388  160 lkAYVTWITLVVFVLPTLIITV--CQV-----LIFKEIHINIYLKSQIIVAVVKKKQLLSsRASSVAEVSKAMIKT---V 229
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755547671 260 RLlkfsrekkaakTLGIVVgCFVLCWLPFFLVMPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIY 326
Cdd:cd15388  230 KM-----------TLVIVL-VYVLCWAPFFLVQLWSVWDPKAPTEGATFTILMLLASLNSCTNPWIY 284
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
27-337 1.91e-19

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 88.04  E-value: 1.91e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLP--FSAIFEilGYWAFGRVFCNIWAA 104
Cdd:cd15401    1 SVLAGVLIFTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAVYPYPliLLAIFH--NGWTLGNIHCQISGF 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 105 VDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQAPEDETICQINE--EP 182
Cdd:cd15401   79 LMGLSVIGSVFNITAIAINRYCYICHSLRYDKLYNMKKTCCYVCLTWVLTLAAIVPNFFVGSLQYDPRIYSCTFAQtvSS 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 183 GYVLFSALGSFYVPLTIILVMYCRVYVVAKRESRGLksglktdKSDSEQVTLRIHRKNVpaegsgvssaknkthfsvrll 262
Cdd:cd15401  159 SYTITVVVVHFIVPLSIVTFCYLRIWVLVIQVKHRV-------RQDSKQKLKANDIRNF--------------------- 210
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755547671 263 kfsrekkaaKTLGIVVGCFVLCWLPFF---LVMPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15401  211 ---------LTMFVVFVLFAVCWGPLNfigLAVAINPLKVAPKIPEWLFVLSYFMAYFNSCLNAVIYGVLNQNFRKEY 279
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
27-337 2.41e-19

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 87.94  E-value: 2.41e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVI-LSVACHR-HLHSVTHYYIVNLAVADLLLTSTvLPFSAIFEILGY-WAFGRVFCNIWA 103
Cdd:cd14976    1 NLVSVVYMVVFTVGLLGNLLVLyLLKSNKKlRQQSESNKFVFNLALTDLIFVLT-LPFWAVEYALDFvWPFGTAMCKVVR 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 104 AVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISI-GPLFGWRQQAPEDETICQI---- 178
Cdd:cd14976   80 YVTKLNMYSSIFFLTALSVTRYIAVARALKHGWIRKAFGAFATTIAIWAAAALAAIpEAIFSTDTWSSVNHTLCLLrfpk 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 179 --------NEEPGYVLFSALGSFYVPLTIILVMYCR-VYVVAKRESRGLKsglktdksdseqvtlrihrknvpaegsgvs 249
Cdd:cd14976  160 nssvtrwyNWLGMYQLQKVVLGFFLPLGIITLSYLLlLRFLQRKRGGSKR------------------------------ 209
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 250 saknkthfsvrllkfsREKKAAKTLGIVVGCFVLCWLPF-----------FLVMPIGSFFpnFKPPETVFKIVFWLGYLN 318
Cdd:cd14976  210 ----------------RKSRVTKSVFIVVLSFFICWLPNqalslwsalikFDDVPFSDAF--FAFQTYAFPVAICLAHSN 271
                        330
                 ....*....|....*....
gi 755547671 319 SCINPIIYPCSSQEFKKAF 337
Cdd:cd14976  272 SCLNPVLYCLVRREFRDAL 290
7tmA_Apelin_R cd15190
apelin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
28-336 2.53e-19

apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Apelin (APJ) receptor is a G protein-coupled receptor that binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake.


Pssm-ID: 341340 [Multi-domain]  Cd Length: 304  Bit Score: 88.28  E-value: 2.53e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  28 LLGVILGGLIIFGVLGNILVILSV-ACHRHLHSVTHYYIVNLAVADLLLTSTvLPFSAIFEILGY-WAFGRVFCNIWAAV 105
Cdd:cd15190   12 LIPVIYMLVFVLGLSGNGLVLWTVfRSKRKRRRSADTFIANLALADLTFVVT-LPLWAVYTALGYhWPFGSFLCKLSSYL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 106 DVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIgPLFGWRQQAPED---ETICQI---- 178
Cdd:cd15190   91 VFVNMYASVFCLTGLSFDRYLAIVRSLASAKLRSRTSGIVALGVIWLLAALLAL-PALILRTTSDLEgtnKVICDMdysg 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 179 ---NEEPGY------VLFSALGsFYVPLTIILVMYCrvyVVAKRESRglksglktdksdseqvtlrihrknvpaegsgvs 249
Cdd:cd15190  170 vvsNESEWAwiaglgLSSTVLG-FLLPFLIMLTCYF---FIGRTVAR--------------------------------- 212
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 250 saknktHFSvrLLKFSREKKAAKTLGIV---VGCFVLCWLPFFLV-----------MPIGSFFPNFKppETVFKIVFWLG 315
Cdd:cd15190  213 ------HFS--KLRRKEDKKKRRLLKIIitlVVTFALCWLPFHLVktlyalmylgiLPFSCGFDLFL--MNAHPYATCLA 282
                        330       340
                 ....*....|....*....|.
gi 755547671 316 YLNSCINPIIYPCSSQEFKKA 336
Cdd:cd15190  283 YVNSCLNPFLYAFFDPRFRQQ 303
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
27-326 2.71e-19

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 87.72  E-value: 2.71e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEIL--GYWAFGRVFCniwAA 104
Cdd:cd15204    1 IVLGVVYVLIMLVCGVGNLLLIAVLARYKKLRTLTNLLIANLALSDFLVAVFCLPFEMDYYVVrqRSWTHGDVLC---AV 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 105 VDVLCCTA---SIMGLCIISIDRYIGVSYPLRYPtiVTQRRGVRALLCVWALSLVISI-GPLFGWRQQAP-EDETIC--- 176
Cdd:cd15204   78 VNYLRTVSlyvSTNALLVIAIDRYLVIVHPLKPR--MKRRTACVVIALVWVVSLLLAIpSAVYSKTTPYAnQGKIFCgqi 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 177 -QINEEP---GYVLFSALGSFYVPltiILVM-YCRVYVVakresrglksglktdksdseqvtLRIHRKNVPAegsgvssa 251
Cdd:cd15204  156 wPVDQQAyykAYYLFLFVLEFVLP---VLIMtLCYLRIV-----------------------RKVWFRRVPG-------- 201
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755547671 252 kNKTHFSVRLLKFSRekKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPE----TVFKIVFWLGYLNSCINPIIY 326
Cdd:cd15204  202 -QQTEQIRRRLRRRR--RKVRLLVVILTAFVLCWAPYYGYAIVRDFFPTLLSKEklntTIFYIVEALAMSNSMINTVVY 277
7tmA_ACKR4_CCR11 cd15176
atypical chemokine receptor 4, member of the class A family of seven-transmembrane G ...
27-220 2.91e-19

atypical chemokine receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR4 was first reported to bind several CC chemokines including CCL19, CCL21, and CCL25 and was originally designated CCR11. AKCR4 is unable to couple to G-protein and, instead, it preferentially mediates beta-arrestin dependent processes, such as receptor internalization, after ligand binding. Thus, ACKR4 may act as a scavenger receptor to suppress the effects of proinflammatory chemokines. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320304 [Multi-domain]  Cd Length: 276  Bit Score: 87.49  E-value: 2.91e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTvLPFSAIFEILGyWAFGRVFCNIWAAVD 106
Cdd:cd15176    1 LFLPVFYTIALVVGLAGNSLVVAIYAYYKKLKTKTDVYILNLAVADLLLLFT-LPFWAADAVNG-WVLGTAMCKITSALY 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVraLLCVWALSLVISIGPLFGWRQQAPEDETICQI-----NEE 181
Cdd:cd15176   79 TMNFSCGMQFLACISVDRYVAITKATSRQFTGKHCWIV--CLCVWLLAILLSIPDLVFSTVRENSDRYRCLPvfppsLVT 156
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 755547671 182 PGYVLFSALG---SFYVPLTIILVMYCRVYVVAKRESRGLKS 220
Cdd:cd15176  157 SAKATIQILEvllGFVLPFLVMVFCYSRVARALSRTPNVKKS 198
7tmA_XCR1 cd15182
XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
36-326 4.17e-19

XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; XCR1 is a chemokine receptor specific for XCL1 and XCL2 (previously called lymphotactin alpha/beta), which differ in only two amino acids. XCL1/2 is the only member of the C chemokine subfamily, which is unique as containing only two of the four cysteines that are found in other chemokine families. Human XCL1/2 has been shown to be secreted by activated CD8+ T cells and upon activation of the innate immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 341337 [Multi-domain]  Cd Length: 271  Bit Score: 87.03  E-value: 4.17e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  36 LIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTvLPFSAIFEILGyWAFGRVFCNIWAAVDVLCCTASIM 115
Cdd:cd15182   10 VFLLSLLGNGLVLWILVKYEKLKTLTNIFILNLAISDLLFTFT-LPFWASYHSSG-WIFGEILCKAVTSIFYIGFYSSIL 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 116 GLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISI-GPLFGWRQQAPEDETICQ---INEEPGYVLFSALg 191
Cdd:cd15182   88 FLTLMTIDRYLAVVHPLSALRSRKLRYASLVSVAVWVISILASLpELILSTVMKSDEDGSLCEyssIKWKLGYYYQQNL- 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 192 SFYVPLTIILVMYCRVyvvakresrgLKSGLKTdksdseqvtlRIHRKnvpaegsgvssaknkthfsvrllkfsreKKAA 271
Cdd:cd15182  167 FFLIPLGIIVYCYVRI----------LQTLMRT----------RTMRK----------------------------HRTV 198
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755547671 272 KTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPETV-------FKIVFWLGYLNSCINPIIY 326
Cdd:cd15182  199 KLIFVIVLVFFLSWAPYNIVIFLRSLKDLTIPICECskqldyaFYICRNIAFSHCCLNPVFY 260
7tmA_MCHR2 cd15339
melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane ...
27-335 5.33e-19

melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320461 [Multi-domain]  Cd Length: 283  Bit Score: 86.79  E-value: 5.33e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHlHSVTHYYIVNLAVADLLLTsTVLPFSaIFEIL--GYWAFGRVFCNIWAA 104
Cdd:cd15339    1 VILPSFIGILCSTGLVGNILVLFTIIRSRK-KTVPDIYVCNLAVADLVHI-IVMPFL-IHQWArgGEWVFGSPLCTIITS 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 105 VDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQAPEDET-ICQIN-EEP 182
Cdd:cd15339   78 LDTCNQFACSAIMTAMSLDRYIALVHPFRLTSLRTRSKTIRINLLVWAASFILVLPVWVYAKVIKFRDGLeSCAFNlTSP 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 183 G----YVLFSALGSFYVPLTIILVMYCRVYVVakresrglksglktdksdseqvTLRIHRKNvpaegsgvssakNKTHFS 258
Cdd:cd15339  158 DdvlwYTLYQTITTFFFPLPLILICYILILCY----------------------TWEMYRKN------------KKAGRY 203
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 259 VRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNfkpPETVFKIVFW----LGYLNSCINPIIYPCSSQEFK 334
Cdd:cd15339  204 NTSIPRQRVMRLTKMVLVLVGVFLVSAAPYHVIQLVNLSVSQ---PTLAFYVSYYlsicLSYASSSINPFLYILLSGNFR 280

                 .
gi 755547671 335 K 335
Cdd:cd15339  281 K 281
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
38-337 6.38e-19

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 86.29  E-value: 6.38e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  38 IFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMGL 117
Cdd:cd15206   12 LLAVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDLLLAVFCMPFTLVGQLLRNFIFGEVMCKLIPYFQAVSVSVSTFTL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 118 CIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIG--------PLFGWRQQAPEDETICQINEEPGYVLFSA 189
Cdd:cd15206   92 VAISLERYFAICHPLKSRVWQTLSHAYKVIAGIWLLSFLIMSPilvfsnliPMSRPGGHKCREVWPNEIAEQAWYVFLDL 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 190 LgSFYVPLTIILVMY---CRVYVVAKresrglksglktdksdseqvtlrihrknvpaegsgvssaknkthfsvrllkfsr 266
Cdd:cd15206  172 M-LLVIPGLVMSVAYgliSWTLLEAK------------------------------------------------------ 196
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755547671 267 eKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPN---FKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15206  197 -KRVIRMLFVIVVEFFICWTPLYVINTWKAFDPPsaaRYVSSTTISLIQLLAYISSCVNPITYCFMNKRFRQAF 269
7tmA_NK1R cd16002
neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
36-337 7.37e-19

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320668 [Multi-domain]  Cd Length: 284  Bit Score: 86.46  E-value: 7.37e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  36 LIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTS--TVLPFSaiFEILGYWAFGRVFCNIWAAVDVLCCTAS 113
Cdd:cd16002   10 IVVVSVVGNIIVMWIILAHKRMRTVTNYFLVNLAFAEASMSAfnTVINFT--YAIHNEWYYGLEYCKFHNFFPIAAVFAS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 114 IMGLCIISIDRYIGVSYPLRYPTIVTQRRGVralLCV-WALSLVISIgPLFGWRQQAP-EDETICQIN--------EEPG 183
Cdd:cd16002   88 IYSMTAIALDRYMAIIHPLQPRLSATATKVV---ICViWVLAFLLAF-PQGYYSDTEEmPGRVVCYVEwpeheerkYETV 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 184 YVLFSALGSFYVPLTIILVMYCRVyvvakresrGLKSGlktdksdseqvtlrihrknvPAEGSGVSSAKNKTHFSVRllk 263
Cdd:cd16002  164 YHVCVTVLIYFLPLLVIGCAYTVV---------GITLW--------------------ASEIPGDSSDRYHEQVSAK--- 211
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755547671 264 fsreKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNF---KPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd16002  212 ----RKVVKMMIVVVCTFAICWLPYHIYFLLQYFHPELyeqKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRVGF 284
7tmA_GPR150 cd15198
G protein-coupled receptor 150, member of the class A family of seven-transmembrane G ...
24-326 7.70e-19

G protein-coupled receptor 150, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors. Its endogenous ligand is not known. These receptors share a significant amino acid sequence similarity, suggesting that they have a common evolutionary origin.


Pssm-ID: 320326 [Multi-domain]  Cd Length: 299  Bit Score: 86.79  E-value: 7.70e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  24 SKAILLGVILggliIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILG-YWAFGRVFCNIW 102
Cdd:cd15198    2 TRLIFLGVIL----VAGVAGNTTVLCWLCGGRRRKSRMNFLLLQLALADLLVIGGTALSQIIWELLGdRWMAGDVACRLL 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 103 AAVDVLCCTASIMGLCIISIDRYIGVSYPLRyptivtQRRGVRALLCV-WALSLVISIGPLFGWRQQAPED-------ET 174
Cdd:cd15198   78 KLLQASARGASANLVVLLALDRHQAIRAPLG------QPLRAWKLAALgWLLALLLALPQAYVFRVDFPDDpasawpgHT 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 175 ICQ--INEEPG-----YVLFSALGSFYVPLTIILVMYCRVYVVAKRESRglksglktdksdseQVTLRIHRKNVPAEGSG 247
Cdd:cd15198  152 LCRgiFAPLPRwhlqvYATYEAVVGFVAPVVILGVCYGRLLLKWWERAN--------------QAPGAKKPWKKPSKSHL 217
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755547671 248 VSSAKNkthfsvrLLKFSREKKAAKTLGIVVgCFVLCWLPFFLVMPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIY 326
Cdd:cd15198  218 RATAPS-------ALPRAKVKTLKMTLVIAL-LFVGCSLPYFIAELAAAFGSGDWEPEKVAAALGVMAVANSATNPFVF 288
7tmA_BRS-3 cd15123
bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...
36-337 1.12e-18

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.


Pssm-ID: 320251 [Multi-domain]  Cd Length: 294  Bit Score: 86.13  E-value: 1.12e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  36 LIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIM 115
Cdd:cd15123   10 IISVGILGNAILIKVFFKIKSMQTVPNIFITSLAFGDLLLLLTCVPVDATRYIADTWLFGRIGCKLLSFIQLTSVGVSVF 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 116 GLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISI-----GPLFGWRQQA-----------PEDETICQin 179
Cdd:cd15123   90 TLTVLSADRYRAIVKPLELQTSDAVLKTCCKAGCVWIVSMLFAIpeavfSDLYSFRDPEknttfeacapyPVSEKILQ-- 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 180 eePGYVLFSALGSFYVPLTIILVMYcrvYVVAKresrglksglktdksdseqvTLRIHRKNVPAEgsgvssaknkTHFSV 259
Cdd:cd15123  168 --EIHSLLCFLVFYIIPLSIISVYY---FLIAR--------------------TLYKSTFNMPAE----------EHSHA 212
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 260 RLLKFSReKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPETVFKIVFW-----LGYLNSCINPIIYPCSSQEFK 334
Cdd:cd15123  213 RKQIESR-KRVAKTVLVLVALFAFCWLPNHILYLYRSFTYHTSVDSSAFHLIATifsrvLAFSNSCVNPFALYWLSKSFR 291

                 ...
gi 755547671 335 KAF 337
Cdd:cd15123  292 QHF 294
7tmA_NTSR1 cd15355
neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G ...
27-337 1.47e-18

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320477 [Multi-domain]  Cd Length: 310  Bit Score: 86.05  E-value: 1.47e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGN---ILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGY--WAFGRVFCNI 101
Cdd:cd15355    1 VLVTAIYLALFVVGTVGNsitLYTLARKKSLQHLQSTVHYHLASLALSDLLILLLAMPVELYNFIWVHhpWAFGDAACRG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 102 WAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFG----WRQQAPEDETICQ 177
Cdd:cd15355   81 YYFLRDACTYATALNVASLSVERYLAICHPFKAKSLMSRSRTKKFISAIWLASALLAIPMLFTmgeqNRSGTHPGGLICT 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 178 --INEEPGYVLFS--ALGSFYVPLTIILVMYCrvyVVAKRESRGLKSGLKTDKsdSEQVTLRIHRKNVPAEGSGVSSAKN 253
Cdd:cd15355  161 piVDTSTLKVVIQvnAFLSFLFPMLVISVLNT---LIANQLTVMVNQAEQENQ--VCTIGGQRTVLSVSMEPGRVQSLRH 235
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 254 kthfSVRLLKfsrekkaaktlgIVVGCFVLCWLPFFLVMPIGSFFPNFKPPETVFKIVFW-------LGYLNSCINPIIY 326
Cdd:cd15355  236 ----GVLVLR------------AVVIAFVVCWLPYHVRRLMFCYVSDEQWTTFLYDFYHYfymltnvLFYVSSAINPILY 299
                        330
                 ....*....|.
gi 755547671 327 PCSSQEFKKAF 337
Cdd:cd15355  300 NLVSANFRQIF 310
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
31-326 1.93e-18

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 85.55  E-value: 1.93e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  31 VILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLL-TSTVLPfSAIFEILGYWAFGRVFCNIWAAVDVLC 109
Cdd:cd15197    5 ATLWVLFVFIVVGNSSVLFALWMRKAKKSRMNFFITQLAIADLCVgLINVLT-DIIWRITVEWRAGDFACKVIRYLQVVV 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 110 CTASIMGLCIISIDRYIGVSYPLRYptiVTQRRGVRALLCV-WALSLVISI--GPLFGWRQQApEDETICQIN-EEPG-- 183
Cdd:cd15197   84 TYASTYVLVALSIDRYDAICHPMNF---SQSGRQARVLICVaWILSALFSIpmLIIFEKTGLS-NGEVQCWILwPEPWyw 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 184 --YVLFSALGSFYVPLTIILVMYCRVYVVAKRESrglksglktdksdSEQVTLRIHRKNVPAEGSGVSSAknkthfsvrl 261
Cdd:cd15197  160 kvYMTIVAFLVFFIPATIISICYIIIVRTIWKKS-------------KIQVTINKAGLHDGSSRRSSSRG---------- 216
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755547671 262 lKFSREK-KAAKTLGIVVGCFVLCWLPFFLVMPIGSF--FPNFKPPETVFKIVFWLGYLNSCINPIIY 326
Cdd:cd15197  217 -IIPRAKiKTIKMTFVIVTVFIICWSPYFVFDLLDVFglLPRSKTKIAAATFIQSLAPLNSAINPLIY 283
7tmA_GPR45 cd15403
G protein-coupled receptor 45, member of the class A family of seven-transmembrane G ...
27-336 2.29e-18

G protein-coupled receptor 45, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR45 and closely related proteins found in vertebrates. GPR45 is also called PSP24 in Xenopus and PSP24-alpha (or PSP24-1) in mammals. GPR45 shows the highest sequence homology with GPR63 (PSP24-beta, or PSP24-2). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320525 [Multi-domain]  Cd Length: 301  Bit Score: 85.28  E-value: 2.29e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVD 106
Cdd:cd15403    1 ILLAIVMILMIAIGFLGNAIVCLIVYQKPAMRSAINLLLATLAFSDIMLSLLCMPFTAVTIITVDWHFGAHFCRISAMLY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIGVsypLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQ-QAPEDETIC-----QINE 180
Cdd:cd15403   81 WFFVLEGVAILLIISVDRFLII---VQRQDKLNPHRAKVMIAISWVLSFCISFPSVVGWTLvEVPARAPQCvlgytESPA 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 181 EPGYVLFSALGSFYVPLTIILVMYCRVYVVAKRESrgLKSGLKTDKSDSEQVTlrihrknvpaeGSGVSSAKNKTHFSVR 260
Cdd:cd15403  158 DRVYAVLLVVAVFFVPFSIMLYSYLCILNTVRRNA--VRIHNHADSLCLSQVS-----------KLGLMGLQRPHQMNVD 224
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755547671 261 LlkfSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPETVFKI---VFWLGYLNSCINPIIYPCSSQEFKKA 336
Cdd:cd15403  225 M---SFKTRAFTTILILFVGFSLCWLPHTVFSLLSVFSRRFYYSSSFYPIstcVLWLSYLKSVFNPVIYCWRIKKFREA 300
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
38-337 2.87e-18

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 84.56  E-value: 2.87e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  38 IFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLtSTVLPFSAIFEIL---------GYWAFGrVFCNIWAAVDVL 108
Cdd:cd15137   12 IIALLGNLFVLIWRLKYKEENKVHSFLIKNLAIADFLM-GVYLLIIASVDLYyrgvyikhdEEWRSS-WLCTFAGFLATL 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 109 CCTASIMGLCIISIDRYIGVSYPLRyPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQAP--EDETIC---QINEE-- 181
Cdd:cd15137   90 SSEVSVLILTLITLDRFICIVFPFS-GRRLGLRRAIIVLACIWLIGLLLAVLPLLPWDYFGNfyGRSGVClplHITDErp 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 182 PG--YVLFSALGSFYVPLTIILVMYCRVYVVAKResrglksglktdksdseqvtlrihrknvpaegsgvssaknkTHFSV 259
Cdd:cd15137  169 AGweYSVFVFLGLNFLAFVFILLSYIAMFISIRR-----------------------------------------TRKAA 207
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 260 RLLKFSREKKAAKTLGIVVGCFVLCWLPFFlVMPIGSFFpNFKPPETVFK--IVFWLGyLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15137  208 ASRKSKRDMAVAKRFFLIVLTDFLCWIPII-VIGILALS-GVPIPGEVYAwvAVFVLP-INSALNPILYTLSTPKFRKKL 284
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
31-326 3.42e-18

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 84.02  E-value: 3.42e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  31 VILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCC 110
Cdd:cd14964    3 IILSLLTCLGLLGNLLVLLSLVRLRKRPRSTRLLLASLAACDLLASLVVLVLFFLLGLTEASSRPQALCYLIYLLWYGAN 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 111 TASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGW----RQQAPEDETICQINEEPGYVL 186
Cdd:cd14964   83 LASIWTTLVLTYHRYFALCGPLKYTRLSSPGKTRVIILGCWGVSLLLSIPPLVGKgaipRYNTLTGSCYLICTTIYLTWG 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 187 FSaLGSFYVPLTIILVMYCRVYVVAKRESRGLKSGLKTDksdseqvtlrihrknvpaegsgvssaknkthfsvrllkFSR 266
Cdd:cd14964  163 FL-LVSFLLPLVAFLVIFSRIVLRLRRRVRAIRSAASLN--------------------------------------TDK 203
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755547671 267 EKKAAKTLGIVVGCFVLCWLPFFLVMPIG--SFFPNFKPPETVFkiVFWLGYLNSCINPIIY 326
Cdd:cd14964  204 NLKATKSLLILVITFLLCWLPFSIVFILHalVAAGQGLNLLSIL--ANLLAVLASTLNPFIY 263
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
31-336 4.51e-18

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 84.08  E-value: 4.51e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  31 VILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTvLPFSaIFEILGY--WAFGRVFCNIWAAVDVL 108
Cdd:cd15132    5 IVCLILFVVGVTGNTMTVLIIRRYKDMRTTTNLYLSSMAVSDLLILLC-LPFD-LYRLWKSrpWIFGEFLCRLYHYISEG 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 109 CCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRgVRALLCV-WALSLvISIGPLFGWRQQAPEDETICQINEEPGYVLF 187
Cdd:cd15132   83 CTYATILHITALSIERYLAICFPLRAKVLVTRRR-VKCVIAAlWAFAL-LSAGPFLFLVGVEQDNNIHPDDFSRECKHTP 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 188 SALGS-------------FYVPLTIILVMYCRVyvvakresrglksGLKTDKSDSeqvtlrihrknvPAEGSGvSSAKNK 254
Cdd:cd15132  161 YAVSSgllgimiwvtttyFFLPMLCLSFLYGFI-------------GRKLWKSKN------------DLRGPN-AAARER 214
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 255 THfsvrllkfsreKKAAKTLGIVVGCFVLCWLPFFLVMPIgsfFPNFKPPETV-----FKIV-FWLGYLNSCINPIIYPC 328
Cdd:cd15132  215 SH-----------RQTVRILAVVVLAFIICWLPFHIGRIL---FANTEDYRTMmfsqyFNIVaMQLFYLSASINPILYNL 280

                 ....*...
gi 755547671 329 SSQEFKKA 336
Cdd:cd15132  281 ISRKYRAA 288
7tmA_AT1R cd15192
type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
27-337 5.31e-18

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 320320 [Multi-domain]  Cd Length: 285  Bit Score: 84.02  E-value: 5.31e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTvLPFSAIFEILGY-WAFGRVFCNIWAAV 105
Cdd:cd15192    1 IMIPTVYSIIFVVGIFGNSLVVIVIYCYMKLKTVANIFLLNLALADLCFLIT-LPLWAAYTAMEYhWPFGNFLCKIASAL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 106 DVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQAPED--ETICQINEEP- 182
Cdd:cd15192   80 VSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTLVVARVTCIVIWLLAGVASLPAIIHRDVFFIENtnITVCAFHYPSq 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 183 ------GYVLFSALGSFYVPLTIILVMYCRVYvvakresRGLKSGLKTDKSDseqvtlrihrknvpaegsgvssaknkth 256
Cdd:cd15192  160 nstllvGLGLMKNLLGFLIPFLIILTCYTLIG-------KALKKAYEIQRNK---------------------------- 204
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 257 fsvrllkfSREKKAAKTLGIVVGCFVLCWLP-----FFLVMPIGSFFPNFKPPE---TVFKIVFWLGYLNSCINPIIYPC 328
Cdd:cd15192  205 --------PRNDEIFKMIMAVVLFFFFCWIPhqiftFLDVLIQLKVIQDCHIADivdTAMPFTICIAYFNSCLNPILYGF 276

                 ....*....
gi 755547671 329 SSQEFKKAF 337
Cdd:cd15192  277 VGKNFRKKF 285
7tmA_MC3R cd15352
melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G ...
36-337 6.43e-18

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320474 [Multi-domain]  Cd Length: 272  Bit Score: 83.40  E-value: 6.43e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  36 LIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEIL--GYWAFGRVFC----NIWAAVDVLC 109
Cdd:cd15352   10 LGIVSLLENILVILAVVKNKNLHSPMYFFLCSLAVADMLVSVSNSLETIMIAVLnsGYLVISDQFIqhmdNVFDSMICIS 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 110 CTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIgplfgwrqqapedetICQINEEPGYVLFSA 189
Cdd:cd15352   90 LVASICNLLAIAVDRYVTIFYALRYHSIMTVRKALVLIAVIWVVCIVCGI---------------VFIVYSESKTVIVCL 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 190 LGSFYVPLTIILVMYCRVYVVAkresrglksglktdksdseqvtlRIHRKNVPAEGSGVSSAKNKTHFsvrllkfsreKK 269
Cdd:cd15352  155 ITMFFAMLVLMATLYVHMFLFA-----------------------RLHVKRIAALPPAVDGAPQQRSC----------MK 201
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755547671 270 AAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNfkPPETVFKIVFWLGYL-----NSCINPIIYPCSSQEFKKAF 337
Cdd:cd15352  202 GAVTITILLGVFIVCWAPFFLHLILIISCPH--NPYCLCYTSHFNTYLvlimcNSVIDPLIYAFRSLEMRKTF 272
7tmA_MCHR1 cd15338
melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...
27-337 1.67e-17

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320460 [Multi-domain]  Cd Length: 282  Bit Score: 82.55  E-value: 1.67e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLH---SVTHYYIVNLAVADLLLTSTvLPFsAIFEILG--YWAFGRVFCNI 101
Cdd:cd15338    1 VIMPSVFGVICFLGIIGNSIVIYTIVKKSKFRcqqTVPDIFIFNLSIVDLLFLLG-MPF-LIHQLLGngVWHFGETMCTL 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 102 WAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLvISIGPLFGWRQQAP-EDETI-CQI- 178
Cdd:cd15338   79 ITALDTNSQITSTYILTVMTLDRYLATVHPIRSTKIRTPRVAVAVICLVWILSL-LSITPVWMYAGLMPlPDGSVgCALl 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 179 --NEEPG---YVLFSALGSFYVPLTIILVMYCRVYvvakresrglksglktdksdseqvtLRIHRKNVPAegsgvssakn 253
Cdd:cd15338  158 lpNPETDtywFTLYQFFLAFALPLVVICVVYFKIL-------------------------QNMASTVAPL---------- 202
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 254 kTHFSVRLlkfsREKKAAKTLGIVVGCFVLCWLPFFLVM--------PIGSFFpnfkppeTVFKIVFWLGYLNSCINPII 325
Cdd:cd15338  203 -PQRSLRV----RTKKVTRMAVAICLAFFICWAPFYILQlahlsidrPSLAFL-------YAYNVAISMGYANSCINPFL 270
                        330
                 ....*....|..
gi 755547671 326 YPCSSQEFKKAF 337
Cdd:cd15338  271 YIMLSETFKRQF 282
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
27-226 2.36e-17

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 82.05  E-value: 2.36e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTvLPFSAIFEILGY-WAFGRVFCNIWAAV 105
Cdd:cd15160    1 IFLPVVYSFVFVVGLPANCLALWVLYLQIKKENVLGVYLLNLSLSDLLYILT-LPLWIDYTANHHnWTFGPLSCKVVGFF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 106 DVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLfgWRQQAPEDE---TICqINEEP 182
Cdd:cd15160   80 FYTNIYASIGFLCCIAVDRYLAVVHPLRFRGLRTRRFALKVSASIWVLELGTHSVFL--GHDELFRDEpnhTLC-YEKYP 156
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 755547671 183 ------GYVLFSALGSFYVPLTIILVMYCRVYvvakRESRGLKSGLKTDK 226
Cdd:cd15160  157 megwqaSYNYARFLVGFLIPLSLILFFYRRVL----RAVRQSPSLEREEK 202
7tmA_CXCR4 cd15179
CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G ...
27-335 2.89e-17

CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR4 is the only known G protein-coupled chemokine receptor for the key homeostatic ligand CXCL12, which is constitutively secreted by bone marrow stromal cells. Atypical chemokine receptor CXCR7 (ACKR3) also binds CXCL12, but activates signaling in a G protein-independent manner. CXCR4 is also a co-receptor for HIV infection and plays critical roles in the development of immune system during both lymphopoiesis and myelopoiesis. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341334 [Multi-domain]  Cd Length: 278  Bit Score: 81.74  E-value: 2.89e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTvLPFSAIFEILGyWAFGRVFCNIWAAVD 106
Cdd:cd15179    1 IFLPTVYSIIFLLGIVGNGLVILVMGYQKKSRTMTDKYRLHLSVADLLFVLT-LPFWAVDAAAN-WYFGNFLCKAVHVIY 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIGVSYplryptiVTQRRGVRALLC-------VWALSLVISIGPLFGWRQQAPEDETIC--- 176
Cdd:cd15179   79 TVNLYSSVLILAFISLDRYLAIVH-------ATNSQRPRKLLAekvvyvgVWLPALLLTVPDLVFAKVSELDDRYICdri 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 177 --QINEEPGYVLFSALG---SFYVPLTIILVMYCRVYvvakresrglksglktdksdseqvtlrihrknvpaegSGVSSA 251
Cdd:cd15179  152 ypEDTFELWVVAFRFQHilvGLVLPGLVILTCYCIII-------------------------------------SKLSHS 194
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 252 KNkthfsvrllkfSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFF------PNFKPPETVFKIVFW---LGYLNSCIN 322
Cdd:cd15179  195 KG-----------HQKRKALKTTVILILAFFACWLPYYIGISIDTFMlleiikQSCEMEQTVHKWISIteaLAFFHCCLN 263
                        330
                 ....*....|...
gi 755547671 323 PIIYPCSSQEFKK 335
Cdd:cd15179  264 PILYAFLGAKFKT 276
7tmA_NMBR cd15125
neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
36-337 6.12e-17

neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin B receptor (NMBR), also known as BB1, is a G-protein coupled receptor whose endogenous ligand is the neuropeptide neuromedin B. Neuromedin B is a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. NMBR is widely distributed in the CNS, with especially high levels in olfactory nucleus and thalamic regions. The receptor couples primarily to a pertussis-toxin-insensitive G protein of the Gq/11 family, which leads to the activation of phospholipase C. NMBR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include gastrin-releasing peptide receptor (GRPR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320253 [Multi-domain]  Cd Length: 292  Bit Score: 81.15  E-value: 6.12e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  36 LIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIM 115
Cdd:cd15125   10 IITVGLLGNITLVKIFITNSAMRSVPNIFISSLAAGDLLLLVTCVPVDASRYFYEEWMFGTVGCKLIPVIQLTSVGVSVF 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 116 GLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIgPLFGWRQQA---PEDE---TIC----QINE-EPG- 183
Cdd:cd15125   90 TLTALSADRYKAIVNPMDIQTSSAVLRTCLKAIAIWVVSVLLAV-PEAVFSEVAhimPDDNttfTACipypQTDEmHPKi 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 184 YVLFSALGSFYVPLTIILVMYcrvYVVAKresrglksglktdksdseqvTLRIHRKNVPAEGSGVSSAKNKThfsvrllk 263
Cdd:cd15125  169 HSVLIFLVYFLIPLAIISIYY---YHIAK--------------------TLIKSAHNIPGEYSEHSKRQMET-------- 217
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755547671 264 fsrEKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPETVFKIVFW----LGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15125  218 ---RKRLAKIVLVFVGLFAFCWFPNHVLYMYRSFNYNEIDSSLGHMIVTLvarvLSFCNSCVNPFALYLLSESFRRHF 292
7tmA_NPY1R cd15395
neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G ...
29-335 7.15e-17

neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320517 [Multi-domain]  Cd Length: 293  Bit Score: 80.63  E-value: 7.15e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  29 LGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVL 108
Cdd:cd15395    3 LALAYSAVIILGVSGNLALIIIILKQKEMHNVTNILIVNLSFSDLLMTIMCLPFTFVYTLMDHWVFGEAMCKLNSMVQCI 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 109 CCTASIMGLCIISIDRYIGVSYPLRYPTivTQRRGVRALLCVWALSLVISIGPLFGWR------------QQAPEDETIC 176
Cdd:cd15395   83 SITVSIFSLVLIAIERHQLIINPRGWRP--NNRHAYVGIAVIWVLAVLTSLPFLIFQVltdepfknvnvsLDAYKGKYVC 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 177 qINEEP------GYVLFSALGSFYVPLTIILVMYCRVYVVAKRESrGLKSGLKTDKSDSEQvTLRIhrknvpaegsgvss 250
Cdd:cd15395  161 -LDQFPsdtirlSYTTCLLVLQYFGPLCFIFICYLKIYIRLKRRN-NMMDKMRDNKYRSSE-TKRI-------------- 223
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 251 aknkthfSVRLLKfsrekkaaktlgIVVGcFVLCWLPFFLVMPIgsFFPNFKPPET-----VFKIVFWLGYLNSCINPII 325
Cdd:cd15395  224 -------NIMLIS------------IVVA-FAVCWLPLNIFNAV--FDWNHEAIATcnhnlLFLICHLTAMISTCVNPIF 281
                        330
                 ....*....|
gi 755547671 326 YPCSSQEFKK 335
Cdd:cd15395  282 YGFLNKNFQR 291
7tmA_LTB4R2 cd15122
leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of ...
31-337 8.33e-17

leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320250 [Multi-domain]  Cd Length: 281  Bit Score: 80.23  E-value: 8.33e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  31 VILGGLIIFGVLGNILVILSVACHR--HLHSVTHYYIVNLAVAD---LLLTstvlPFSAIFEILGYWAFGRVFCNiwaAV 105
Cdd:cd15122    5 IFLLLAALLGLPGNGFIIWSILWKMkaRGRSVTCILILNLAVADgavLLLT----PFFITFLTRKTWPFGQAVCK---AV 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 106 DVLCCT---ASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFG---WRQQAPEDeTICQ-I 178
Cdd:cd15122   78 YYLCCLsmyASIFIIGLMSLDRCLAVTRPYLAQSLRKKALVRKILLAIWLLALLLALPAFVYrhvWKDEGMND-RICEpC 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 179 NEEPGYVLF----SALGSFYVPLTIILVMYCRVYVvakresrglksglktdksdseqvtlrihrknvpaegsgvssaknk 254
Cdd:cd15122  157 HASRGHAIFhytfETLVAFVLPFGVILFSYSVILV--------------------------------------------- 191
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 255 thfSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIgSFFPNFKPPETVFKI----------VFWLGYLNSCINPI 324
Cdd:cd15122  192 ---RLKGARFRRRARVEKLIAAIVVAFALLWVPYHVVNLL-QVVANLAPGEVLEKLggaakaaragATALAFFSSSVNPL 267
                        330
                 ....*....|...
gi 755547671 325 IYPCSSQEFKKAF 337
Cdd:cd15122  268 LYVFAAGDLIKTS 280
7tmA_C5aR cd15114
complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of ...
27-337 8.90e-17

complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320242 [Multi-domain]  Cd Length: 274  Bit Score: 80.14  E-value: 8.90e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHlHSVTHYYIVNLAVADLLLTSTvLPFSAIFEIL-GYWAFGRVFCNIWAAV 105
Cdd:cd15114    1 VVALVLYAVVFLVGVPGNALVAWVTGFEAK-RSVNAVWFLNLAVADLLCCLS-LPILAVPIAQdGHWPFGAAACKLLPSL 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 106 DVLCCTASIMGLCIISIDRYIGVSYPLRYPTiVTQRRGVRALLCV-WALSLVISIgPLFGWRQQAPE---DETICQIN-- 179
Cdd:cd15114   79 ILLNMYASVLLLTAISADRCLLVLRPVWCQN-HRRARLAWIACGAaWLLALLLTV-PSFIYRRIHQEhfpEKTVCVVDyg 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 180 ----EEPGYVLFSALGSFYVPLTIILVMYCRVYVVAKRESRglksglktdksdseqvtlrihrknvpaegsgvssakNKT 255
Cdd:cd15114  157 gstgVEWAVAIIRFLLGFLGPLVVIASCHGVLLVRTWSRRR------------------------------------QKS 200
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 256 HFSVRLLkfsrekkaaktLGIVVGcFVLCWLPFFLVMPIGSFFPnfkPPETVFK-------IVFWLGYLNSCINPIIYPC 328
Cdd:cd15114  201 RRTLKVV-----------TAVVVG-FFLCWTPYHVVGLIIAASA---PNSRLLAnalkadpLTVSLAYINSCLNPIIYVV 265

                 ....*....
gi 755547671 329 SSQEFKKAF 337
Cdd:cd15114  266 AGRGFRKSL 274
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
31-326 1.07e-16

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 80.25  E-value: 1.07e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  31 VILGGLIIFGVL-GNILVILSVACHRHLHSVTHYYIVNLAVADLLLTS-TVLPfSAIFEILGYWAFGRVFCNIWAAVDVL 108
Cdd:cd15387    4 VTVLALILFLALtGNICVLLAIHTTRHKHSRMYFFMKHLSIADLVVAVfQVLP-QLIWDITFRFYGPDFLCRLVKYLQVV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 109 CCTASIMGLCIISIDRYIGVSYPLRYptiVTQRRGVRALLCVWALSLVISIGP--LFGWRQQAPEDETICQINEEP---- 182
Cdd:cd15387   83 GMFASTYMLLLMSIDRCLAICQPLRS---LHRRSDRVYVLFSWLLSLVFSIPQvhIFSLREVGNGVYDCWADFIQPwgpk 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 183 GYVLFSALGSFYVPLTIILVMYCRVYVVAKRESRglksgLKTDKSDSEQVTLRIHRKNVPAEGSgvssaknkthfSVRLL 262
Cdd:cd15387  160 AYITWITLSVYIIPVLILSVCYGLISFKIWQNVK-----LKTRRETKTPLSSAASGGAALARVS-----------SVKLI 223
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755547671 263 kfSREK-KAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIY 326
Cdd:cd15387  224 --SKAKiRTVKMTFVIVLAYIVCWTPFFFVQMWSVWDPNAPKEASPFIIAMLLASLNSCCNPWIY 286
7tmA_MC2R_ACTH_R cd15350
melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of ...
38-337 1.14e-16

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320472 [Multi-domain]  Cd Length: 270  Bit Score: 79.82  E-value: 1.14e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  38 IFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLL--LTSTVLPFSAIFEILGYW----AFGRVFCNIWAAVDVLCCT 111
Cdd:cd15350   12 AVGLLENLLVLVAVIKNKNLHSPMYFFICSLAVSDMLgsLYKTLENILIILADMGYLnrrgPFETKLDDIMDSLFCLSLL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 112 ASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGplfgwrqqapedeTICQINEEPGYVLFSALg 191
Cdd:cd15350   92 GSIFSILAIAADRYITIFHALRYHNIMTMRRTLVILAIIWTFCGGSGIL-------------MILFFHFVATVICFTVL- 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 192 sFYVPLTIILVMYCRVYVVAkresrglksglktdksdseqvtlRIHRKNVpAEGSGVSSAKNKTHFsvrllkfsrekKAA 271
Cdd:cd15350  158 -FFLMLVLILCLYVHMFLLA-----------------------RSHARKI-ASLPNHHAQHQRSNM-----------RGA 201
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755547671 272 KTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPE---TVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15350  202 ITLTILLGVFVCCWAPFVLHLLLMMFCPMNPYCAcyrSLFQVNGTLIMSHAVIDPAIYAFRSPELRNTF 270
7tmA_CXCR6 cd15173
CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
38-337 1.22e-16

CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR6 binds specifically to the chemokine CXCL16, which is expressed on dendritic cells, monocyte/macrophages, activated T cells, fibroblastic reticular cells, and cancer cells. CXCR6 is phylogenetically more closely related to CC-type chemokine receptors (CCR6 and CCR9) than other CXC receptors. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320301 [Multi-domain]  Cd Length: 270  Bit Score: 79.81  E-value: 1.22e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  38 IFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTvLPFSAIFEILGyWAFGRVFCNIWAAVDVLCCTASIMGL 117
Cdd:cd15173   12 VTGLVGNSLVIVIYIFYEKLRTLTDIFLVNLAVADLLFLCT-LPFWAYSAAHE-WIFGTVMCKITNGLYTINLYSSMLIL 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 118 CIISIDRYIGVSYPLRYPTIVTQRRGVRALLC--VWALSLVISIgPLFGWRQQAPEDETICQINEEPGY----VLFSALG 191
Cdd:cd15173   90 TCITVDRFIVIVQATKAHNCHAKKMRWGKVVCtlVWVISLLLSL-PQFIYSEVRNLSSKICSMVYPPDAievvVNIIQMT 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 192 -SFYVPLTIILVMYCrvyVVAKresrglksglktdksdseqvTLrIHRKNVpaegsgvssaknkthfsvrllkfsREKKA 270
Cdd:cd15173  169 vGFFLPLLAMIICYS---VIIK--------------------TL-LHAKGF------------------------QKHKS 200
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755547671 271 AKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKpPETVFK----IVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15173  201 LKIIFVVVAVFILTQLPYNIMKLIRTLHIENT-DSTNFKyailITEAIAYLHACLNPILYAFVGVKFRKNF 270
7tmA_C3aR cd15115
complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of ...
27-335 1.37e-16

complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320243 [Multi-domain]  Cd Length: 265  Bit Score: 79.43  E-value: 1.37e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILsVACHRHLHSVTHYYIVNLAVADLLLTSTvLPFSAIFEIL-GYWAFGRVFCNIWAAV 105
Cdd:cd15115    1 ILSLVVLSLTFLLGVPGNGLVIW-VAGLKMKRTVNTIWFLNLAVADLLCCLS-LPFSIAHLLLnGHWPYGRFLCKLLPSI 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 106 DVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIgPLFGWRQQAPEDE-TICQINEEPGY 184
Cdd:cd15115   79 IVLNMFASVFTLTAISLDRFLLVIKPVWAQNHRSVLLACLLCGCIWILALLLCL-PVFIYRTTVTDGNhTRCGYDFLVAI 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 185 VLFSALGSFYVPLTIILVMYCRVYVVAKRESRGLKSGlktdksdseqvtlrihrknvpaegsgvssaknkthfsvrllkf 264
Cdd:cd15115  158 TITRAVFGFLLPLLIIAACYSFIAFRMQRGRFAKSQS------------------------------------------- 194
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755547671 265 srekKAAKTLGIVVGCFVLCWLPFFLVMPIGSffpnFKPPETVFKIVFW------LGYLNSCINPIIYPCSSQEFKK 335
Cdd:cd15115  195 ----KTFRVIIAVVVAFFVCWAPYHIIGILSL----YGDPPLSKVLMSWdhlsiaLAYANSCLNPVLYVFMGKDFKK 263
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
24-326 2.96e-16

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 78.66  E-value: 2.96e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  24 SKAILLGVIlgglIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILG-YWAFGRVFCNIW 102
Cdd:cd15212    2 AQALVLLAI----FLLSSLGNCAVIGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPFAFLTLFSRpGWLFGDRLCLAN 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 103 AAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPtiVTQRRGVRALLCVWALSLVISigplFGWRQQAPEDETICQIN-EE 181
Cdd:cd15212   78 GFFNACFGIVSTLTMTLISFDRYYAIVRQPQGK--IGRRRALQLLAAAWLTALGFS----LPWYLLASAPEYYEKLGfYH 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 182 PGYVLFSALGSFYVPLTIILVMYCRVyvvakresrgLKSGLKTDKSDSEQVTLRIHRKNV-PAEGSGvssaknkthfsvR 260
Cdd:cd15212  152 CLYVLHSGPSRLGAAYSSVLIVLCYL----------LPFALMCFCHYNICKTVRLSESRVrPVTTYA------------H 209
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755547671 261 LLKFSREKKAAKTLGIVVGCFVLCWLPfFLVMPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIY 326
Cdd:cd15212  210 LLRFYSEMRTATTVLIMIVFIICCWGP-YCLLGLVAAAGGYQFPPLMDTVAIWMAWANGAINPLIY 274
7tmA_S1PR cd15102
sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G ...
39-337 3.28e-16

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320230 [Multi-domain]  Cd Length: 270  Bit Score: 78.28  E-value: 3.28e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  39 FGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLL-----LTSTVLPFSAIFEILGYWAFGR---VFCNIwaavdvlcc 110
Cdd:cd15102   13 FIVLENLLVLIAIWRHMKFHRPMYYFLGNLALSDLLagaayLANILLSGARTLRLSPAQWFLRegsMFVAL--------- 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 111 TASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCvWALSLVISIGPLFGWR--QQAPEDETICQINEEpGYVLFs 188
Cdd:cd15102   84 SASVFSLLAIAIERHLTMAKMKPYGASKTSRVLLLIGAC-WLISLLLGGLPILGWNclGALDACSTVLPLYSK-HYVLF- 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 189 ALGSFYVPLTIILVMYCRVYVVAKRESRglksglktdksdseqvtlrihrkNVPAegsgvSSAKNKthfSVRLLKfsrek 268
Cdd:cd15102  161 CVTIFAGILAAIVALYARIYCLVRASGR-----------------------KATR-----ASASPR---SLALLK----- 204
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755547671 269 kaakTLGIVVGCFVLCWLPFFLVMPIGSFFPNfKPPETVFKI--VFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15102  205 ----TVLIVLLVFIACWGPLFILLLLDVACPV-KTCPILYKAdwFLALAVLNSALNPIIYTLRSRELRRAV 270
7tmA_HCAR-like cd14991
hydroxycarboxylic acid receptors and related proteins, member of the class A family of ...
29-335 3.30e-16

hydroxycarboxylic acid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the hydroxycarboxylic acid receptors (HCARs) as well as their closely related receptors, GPR31 and oxoeicosanoid receptor 1 (OXER1). HCARs are members of the class A family of G-protein coupled receptors (GPCRs). HCAR subfamily contain three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2, orGPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. All three HCA receptors are expressed in adipocytes, and are coupled to G(i)-proteins mediating anti-lipolytic effects in fat cells. OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid, whereas GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE).


Pssm-ID: 320122 [Multi-domain]  Cd Length: 280  Bit Score: 78.64  E-value: 3.30e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  29 LGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTvLPFSAIFEILG-YWAFGRVFCNIWAAVDV 107
Cdd:cd14991    3 LPPLLILEFVLGLPGNVVALWIFCFHSRTWKANTVYLFNLVLADFLLLIC-LPFRIDYYLRGeHWIFGEAWCRVNLFMLS 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 108 LCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQAPEDETICQ--INEEPG-- 183
Cdd:cd14991   82 VNRSASIAFLTAVALDRYFKVVHPHHRVNRMSVKAAAGVAGLLWALVLLLTLPLLLSTLLTVNSNKSSCHsfSSYTKPsl 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 184 -----YVLFsaLGSFYVPLTIILvmYCRVYVVAKRESRGLKSGLKtdksdseqvtlrihrknvpaegsgvssaknkthfs 258
Cdd:cd14991  162 sirwhNALF--LLEFFLPLGLIV--FCSVRIACNLRIRQSLGKQA----------------------------------- 202
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 259 vrllkfsREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPET------VFKIVFWLGYLNSCINPIIYPCSSQE 332
Cdd:cd14991  203 -------RVQRAIRLVFLVVIVFVLCFLPSIIAGLLALVFKNLGSCRClnsvaqLFHISLAFTYLNSALDPVIYCFSSPW 275

                 ...
gi 755547671 333 FKK 335
Cdd:cd14991  276 FRN 278
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
31-328 3.51e-16

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 78.68  E-value: 3.51e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  31 VILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTvLPFSAIFEILGYWAFGRVFCNIWAAVDVLCC 110
Cdd:cd14975    5 TLLSLAFAIGLPGNSFVIWSILIKVKQRSVTMLLVLNLALADLAVLLT-LPVWIYFLATGTWDFGLAACKGCVYVCAVSM 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 111 TASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIgPLFGWRQ-QAPEDETICQIN-----EEPGY 184
Cdd:cd14975   84 YASVFLITLMSLERFLAVSRPFVSQGWRAKALAHKVLAIIWLLAVLLAT-PVIAFRHvEETVENGMCKYRhysdgQLVFH 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 185 VLFSALGSFYVPLTIILVMYCRVYVvakresrglksglktdksdseqvtlRIHRKnvpaegsgvssaknkthfsvrllKF 264
Cdd:cd14975  163 LLLETVVGFAVPFTAVVLCYSCLLR-------------------------RLRRR-----------------------RF 194
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755547671 265 SREKKAAKTLGIVVGCFVLCWLPFFL--VMPIGSFFPNF--------KPPETVFKIVFWLGYLNSCINPIIYPC 328
Cdd:cd14975  195 RRRRRTGRLIASVVVAFAACWLPYHVgnLLEVVSELIGGskmagtlgKVAEAGRPIAGALAFLSSSINPLLYAF 268
7tmA_GPR34-like cd15920
P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G ...
38-336 4.25e-16

P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR34 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR34 is shown to couple to G(i/o) protein and is highly expressed in microglia. Recently, lysophosphatidylserine has been identified as a ligand for GPR34. This group belongs to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320586 [Multi-domain]  Cd Length: 278  Bit Score: 78.30  E-value: 4.25e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  38 IFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLtSTVLPFSAIFEIlgyWAFGRVFCNIWAAVDVLCCTASIMGL 117
Cdd:cd15920   12 IVGLLSNTLALWVFFLRQQRETSISVYMRNLALADLLL-VLCLPFRVAYQN---TAGPLSFCKIVGAFFYLNMYASILFL 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 118 CIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQAPEDETICQINEE---PGYVLFSALGSFY 194
Cdd:cd15920   88 SLISLDRYLKIIKPLQQFKIHTVPWSSAASGGVWLLLLACMIPFLFESRNEGPCDNKCFHFRSKgltAGGINLTAVVIFY 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 195 VPLTIILVMYCRVYVVAKRESRGlksglktdksDSEQVTLRIhrknvpaegsgvssaknkthfsvrllkfsrEKKAAKTL 274
Cdd:cd15920  168 ILSLLFLYFYAKISHKLYKVSLG----------NAQQQIKKA------------------------------SKRAIIKT 207
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 275 GIVVGCFVLCWLPFFLV--------MPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKA 336
Cdd:cd15920  208 FIVLAIFIVCFVPYHIVrvpyvlaqIDVISSLPWKQTLHIANELVLCLSALNSCLDPIIYFFLSSSFRRA 277
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
37-337 4.45e-16

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 78.28  E-value: 4.45e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  37 IIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLP--FSAIFeiLGYWAFGRVFCNIWAAVDVLCCTASI 114
Cdd:cd15209   11 IVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAIYPYPliLHAIF--HNGWTLGQLHCQASGFIMGLSVIGSI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 115 MGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLF-GWRQQAPEDETiCQINE--EPGYVLFSALG 191
Cdd:cd15209   89 FNITAIAINRYCYICHSLQYDRLYSLRNTCCYLCLTWLLTVLAVLPNFFiGSLQYDPRIYS-CTFAQtvSTVYTITVVVI 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 192 SFYVPLTIILVMYCRVY--VVAKRESRGLKSGLKTDKSDSEQVTlrihrknvpaegsgvssaknkTHFSVRLLkfsrekk 269
Cdd:cd15209  168 HFLLPLLIVSFCYLRIWvlVLQVRQRVKPDQRPKLKPADVRNFL---------------------TMFVVFVL------- 219
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755547671 270 aaktlgivvgcFVLCWLPF-FLVMPIGSFFPNFKP--PETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15209  220 -----------FAVCWAPLnFIGLAVAINPKEMAPkiPEWLFVASYFMAYFNSCLNAIIYGLLNQNFRKEY 279
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
37-337 4.51e-16

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 78.32  E-value: 4.51e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  37 IIF--GVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASI 114
Cdd:cd15979    9 VIFllSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLMLAVFCMPFTLIPNLMGTFIFGEVICKAVAYLMGVSVSVST 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 115 MGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIG-PLFGWRQQAPEDE----TICQ-----INEEPGY 184
Cdd:cd15979   89 FSLVAIAIERYSAICNPLQSRVWQTRSHAYRVIAATWLLSGLIMIPyPVYSVTVPVPVGDrprgHQCRhawpsAQVRQAW 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 185 VLFSALGSFYVPLTIILVMYCRVyvvakreSRGLKSGLKTdksdseqvtlrihrknvpaegsgvssaknkthfsvrllkf 264
Cdd:cd15979  169 YVLLLLILFFIPGVVMIVAYGLI-------SRELYRGLLA---------------------------------------- 201
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 265 srEKKAAKTLGIVVGCFVLCWLPFFLVmpigSFFPNFKPPE-------TVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15979  202 --KKRVIRMLVVIVAMFFLCWLPIFSA----NTWRAFDPLSahralsgAPISFIHLLSYTSACVNPLVYCFMNRRFRKAF 275
7tmA_Parapinopsin cd15075
non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled ...
27-326 4.58e-16

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.


Pssm-ID: 320203 [Multi-domain]  Cd Length: 279  Bit Score: 78.28  E-value: 4.58e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVD 106
Cdd:cd15075    1 TILSIIMAVFSIASVVLNATVIIVTLRHKQLRQPLNYALVNLAVADLGTTVFGGLLSVVTNAVGYFNLGRVGCVLEGFAV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIGVSYPLRYPTIvTQRRGVRALLCVWALSLVISIGPLFGW-RQQAPEDETICQIN---EEP 182
Cdd:cd15075   81 AFFGIAALCTVAVIAVDRLFVVCKPLGTLTF-QTRHALAGIASSWLWSLIWNTPPLFGWgSYQLEGVMTSCAPDwysRDP 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 183 ---GYVLFSALGSFYVPLTIILVMYCRVYvvakresrglksglktdksdseqVTLRIHRKNVPAEGSGVSSAknkthfsv 259
Cdd:cd15075  160 vnvSYILCYFSFCFAIPFAIILVSYGYLL-----------------------WTLRQVAKLGVAEGGSTAKA-------- 208
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755547671 260 rllkfsrEKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIY 326
Cdd:cd15075  209 -------EVQVARMVVVMVMAFLLCWLPYAAFALTVVSKPDVYINPLIATVPMYLAKSSTVYNPIIY 268
7tmA_Mel1B cd15400
melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
41-337 5.15e-16

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320522 [Multi-domain]  Cd Length: 279  Bit Score: 77.97  E-value: 5.15e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  41 VLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLP--FSAIFEilGYWAFGRVFCNIWAAVDVLCCTASIMGLC 118
Cdd:cd15400   15 ILGNLLVIISVFRNRKLRNSGNVFVVSLALADLVVALYPYPlvLVAIFH--NGWALGEMHCKVSGFVMGLSVIGSIFNIT 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 119 IISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQAPEDETICQINE--EPGYVLFSALGSFYVP 196
Cdd:cd15400   93 GIAINRYCYICHSFAYDKLYSRWNTLLYVCLIWALTVVAIVPNFFVGSLEYDPRIYSCTFVQtaSSSYTIAVVVIHFIVP 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 197 LTIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEqvtlrihrknvpaegsgvssaknkthfsvrLLKFSrekkaakTLGI 276
Cdd:cd15400  173 ITVVSFCYLRIWVLVIQVRRKVKSESKPRLKPSD------------------------------FRNFL-------TMFV 215
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755547671 277 VVGCFVLCWLPFFLVMPIGSFFPNF---KPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15400  216 VFVIFAICWAPLNLIGLAVAINPQEmapKVPEWLFVVSYFMAYFNSCLNAIIYGLLNQNFRKEY 279
7tmA_CB2 cd15341
cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G ...
27-336 5.77e-16

cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320463 [Multi-domain]  Cd Length: 279  Bit Score: 77.96  E-value: 5.77e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHY-YIVNLAVADLLlTSTVLPFS-AIFEILGYWAFGRVFCNIWAA 104
Cdd:cd15341    1 IAIAVLCTLCGLLCILENVAVLYLILSSPKLRRKPSYlFIGSLALADFL-ASVVFACSfVDFHVFHGVDSSAIFLLKLGG 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 105 VDvLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWrqqapedeTICQINeEPGY 184
Cdd:cd15341   80 VT-MSFTASLGSLLLMAFDRYVCIYYPSEYKALVTRKRALVALAVMWVLTALIAYLPLMGW--------NCCPLN-SPCS 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 185 VLFSALGSFYVPLTIILVMY---CRVYVVAkresrglksglktdksdseQVTLRIHRKNVPAEGSGVSSAKN--KTHFSV 259
Cdd:cd15341  150 ELFPLIPNDYLLSWLLLVAIllsGIIYTYG-------------------HVLWKAHKHVVYMEKHQDQQGPGnaRMRLDV 210
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755547671 260 RLlkfsrekkaAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKA 336
Cdd:cd15341  211 RL---------AKTLGLVLAVLLICWSPVLALMMHSLFTSLSDHIKKAFAFCSTLCLVNSMVNPIIYALRSRELRSS 278
7tmA_tmt_opsin cd15086
teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G ...
27-337 9.50e-16

teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G protein-coupled receptors; Teleost multiple tissue (tmt) opsins are homologs of encephalopsin. Mouse encephalopsin (or panopsin) is highly expressed in the brain and testes, whereas the teleost homologs are localized to multiple tissues. The exact functions of the encephalopsins and tmt-opsins are unknown. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Tmt opsins belong to the class A of the G protein-coupled receptors and show strong homology to the vertebrate visual opsins.


Pssm-ID: 320214 [Multi-domain]  Cd Length: 276  Bit Score: 77.08  E-value: 9.50e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVD 106
Cdd:cd15086    1 TVVAVFLGFILTFGFLNNLLVLVLFCKYKVLRSPINLLLLNISLSDLLVCVLGTPFSFAASTQGRWLIGEHGCRWYGFAN 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIgvsyPLRYPTIVTQRRGVRALLCV---WALSLVISIGPLFGWRQQAPEDE-TICQIN--- 179
Cdd:cd15086   81 SLFGIVSLISLAVLSYERYC----TLLRPTEADVSDYRKAWLGVggsWLYSLLWTLPPLLGWSSYGPEGPgTTCSVQwts 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 180 ---EEPGYVLFSALGSFYVPLTIILVMYCRVYVVAKRESrglksglKTDKSDSEQvtlrihrknvpaegsgvssaknkth 256
Cdd:cd15086  157 rsaNSISYIICLFIFCLLLPFLVMVYCYGRLLYAIKQVG-------KINKSTARK------------------------- 204
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 257 fsvrllkfsREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSF-FPNFKPPETVFkIVFWLGYLNSCINPIIYPCSSQEFKK 335
Cdd:cd15086  205 ---------REQHVLLMVVTMVICYLLCWLPYGVMALLATFgKPGLVTPVASI-VPSILAKSSTVVNPIIYVFMNKQFYR 274

                 ..
gi 755547671 336 AF 337
Cdd:cd15086  275 CF 276
7tmA_Bradykinin_R cd15189
bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
36-335 1.20e-15

bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320317 [Multi-domain]  Cd Length: 284  Bit Score: 77.12  E-value: 1.20e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  36 LIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTvLPFSAIfEILGY--WAFGRVFCNIWAAVDVLCCTAS 113
Cdd:cd15189   10 LCLFGLLGNLFVLLVFLLHRRRLTVAEIYLGNLAAADLVFVSG-LPFWAM-NILNQfnWPFGELLCRVVNGVIKVNLYTS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 114 IMGLCIISIDRYIGVSYPLRYPTIvtQRRGVRALLCV--WALSLVISIgPLFGWR--QQAPE-DETICQINEEPG----- 183
Cdd:cd15189   88 IYLLVMISQDRYLALVKTMAARRL--RRRRYAKLICVliWVVGLLLSI-PTFLLRkiKAIPDlNITACVLLYPHEawhfa 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 184 -YVLFSALGsFYVPLTIILvmYCRVYVVAKRESRGlKSGLKTDKSDSeqvtlrihrknvpaegsgvssaknkthfsvrll 262
Cdd:cd15189  165 hIVLLNIVG-FLLPLLVIT--FCNYNILQALRTRE-ESTRCEDRNDS--------------------------------- 207
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 263 kfsrekKAAKTLGIVVGCFVLCWLPFFLVMpigsfFPNFKPPETVFKIVFW-------------LGYLNSCINPIIYPCS 329
Cdd:cd15189  208 ------KATALVLAVTLLFLVCWGPYHFFT-----FLDFLFDVGVLDECFWehfidiglqlavfLAFSNSCLNPVLYVFV 276

                 ....*.
gi 755547671 330 SQEFKK 335
Cdd:cd15189  277 GRYFRR 282
7tmA_CXCR3 cd15180
CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
27-337 1.20e-15

CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR3 is an inflammatory chemotactic receptor for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. CXCR3 specifically binds three chemokines CXCL9 (monokine induced by gamma-interferon), CXCL10 (interferon induced protein of 10 kDa), and CXCL11 (interferon inducible T-cell alpha-chemoattractant, I-TAC). CXC3R is expressed on CD4+ Th1 and CD8+ cytotoxic T lymphocytes as well as highly on innate lymphocytes, such as NK cells and NK T cells, where it may mediate the recruitment of these cells to the sites of infection and inflammation. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341335 [Multi-domain]  Cd Length: 280  Bit Score: 77.04  E-value: 1.20e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTvLPFSAIFEILGyWAFGRVFCNIWAAVD 106
Cdd:cd15180    1 VFLPVLYSLVFLLGLLGNGLVLAVLLQKRRNLSVTDTFILHLALADILLLVT-LPFWAVQAVHG-WIFGTGLCKLAGAVF 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIGVSYPLRyptIVTQRRGVRALLC---VWALSLVISIGPL--FGWRQQAPEDETICQINeE 181
Cdd:cd15180   79 KINFYCGIFLLACISFDRYLSIVHAVQ---MYSRKKPMLVHLScliVWLFCLLLSIPDFifLEATKDPRQNKTECVHN-F 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 182 PGYVLFSALGS--------FYVPLTIILVMYCRVYVVAKRESRGLKsglktdksdseqvtlrihrknvpaegsgvssakn 253
Cdd:cd15180  155 PQSDTYWWLALrllyhivgFLLPLAVMVYCYTSILLRLLRSSQGFQ---------------------------------- 200
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 254 kthfsvrllkfsrEKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPP---------ETVFKIVFWLGYLNSCINPI 324
Cdd:cd15180  201 -------------KQRAIRVIVAVVVVFFLCWTPYNIALLVDTLIDLSVLDrncgtesrlDIALSVTSSLGYFHCCLNPL 267
                        330
                 ....*....|...
gi 755547671 325 IYPCSSQEFKKAF 337
Cdd:cd15180  268 LYAFVGVKFRRKL 280
7tmA_P2Y6_P2Y3-like cd15968
P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of ...
27-333 1.55e-15

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes P2Y receptor 6 (P2Y6), P2Y3, and P2Y3-like proteins. These receptors belong to the G(i) class of a family of purinergic G-protein coupled receptors. In the CNS, P2Y6 plays a role in microglia activation and phagocytosis, and is involved in the secretion of interleukin from monocytes and macrophages in the immune system. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320634 [Multi-domain]  Cd Length: 285  Bit Score: 76.74  E-value: 1.55e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLtSTVLPFSAIFEILG-YWAFGRVFCNIWAAV 105
Cdd:cd15968    1 ILLPICYSFVFLLGLPLNSVVLTRCCRHTKAWTRTAIYMVNLALADLLY-ALSLPLLIYNYAMRdRWLFGDFMCRLVRFL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 106 DVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQAPEDETIC---QINEE- 181
Cdd:cd15968   80 FYFNLYGSILFLTCISVHRYLGICHPMRPWHKETRRAAWLTCVLVWILVFAQTLPILIFARTGIIRNRTVCydlAPPALf 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 182 PGYVLFS---ALGSFYVPLTIILVMYCRvyvvakresrglksglktdksdseqVTLRIHRKNVPAEGSGVssaknkthfs 258
Cdd:cd15968  160 PHYVPYGmalTVSGFLLPFSIILWCYCL-------------------------VVRTLCRTLGPAEPPAQ---------- 204
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 259 vrllkfSREKKAAKTLGIVVGCFVLCWLPF------FLVMPIGSFFP--NFKPPETVFKIVFWLGYLNSCINPIIYPCSS 330
Cdd:cd15968  205 ------ARRRKSIRTIVTVTLLFALCFLPFhitrtiYLAVRVTPGVPchVLEAVAACYKITRPLASANSVLNPLLYFLTK 278

                 ...
gi 755547671 331 QEF 333
Cdd:cd15968  279 KKF 281
7tmA_Pinopsin cd15084
non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...
18-341 1.56e-15

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320212 [Multi-domain]  Cd Length: 295  Bit Score: 76.82  E-value: 1.56e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  18 PAQVNISKAILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRV 97
Cdd:cd15084    2 PHLAPRSTYLTVAVLMGMVVALASFVNGLVIVVSIKYKKLRSPLNYILVNLAVADLLVTLFGSSVSFSNNIVGFFVFGKT 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  98 FCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPL---RYptivTQRRGVRALLCVWALSLVISIGPLFGWRQQAPED-E 173
Cdd:cd15084   82 MCEFEGFMVSLTGIVGLWSLAILAFERYLVICKPMgdfRF----QQRHAVSGCAFTWGWSLLWTSPPLFGWSSYVPEGlR 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 174 TICQINEEPG------YVLFSALGSFYVPLTIILVMYCRVYvvakresrglksglktdksdseqVTLRihrknvpaegsG 247
Cdd:cd15084  158 TSCGPNWYTGgtnnnsYILALFVTCFALPLSTIIFSYSNLL-----------------------LTLR-----------A 203
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 248 VSSAKNKTHFSVRllkfsREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIYP 327
Cdd:cd15084  204 VAAQQKESETTQR-----AEKEVTRMVIAMVMAFLICWLPYATFAMVVATNKDVVIQPTLASLPSYFSKTATVYNPIIYV 278
                        330
                 ....*....|....
gi 755547671 328 CSSQEFKKAFQNVL 341
Cdd:cd15084  279 FMNKQFRSCLLELL 292
7tmA_CCR1 cd15183
CC chemokine receptor type 1, member of the class A family of seven-transmembrane G ...
36-335 1.58e-15

CC chemokine receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR1 is widely expressed on both hematopoietic and non-hematopoietic cells and binds to the inflammatory CC chemokines CCL3, CCL5, CCL6, CCL9, CCL15, and CCL23. CCR1 activates the typical chemokine signaling pathway through the G(i/o) type of G proteins, causing inhibition of adenylate cyclase and stimulation of phospholipase C, PKC, calcium flux, and PLA2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320311 [Multi-domain]  Cd Length: 278  Bit Score: 76.45  E-value: 1.58e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  36 LIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTvLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIM 115
Cdd:cd15183   10 VFIIGVVGNVLVVLVLIQHKRLRNMTSIYLFNLAISDLVFLFT-LPFWIDYKLKDDWIFGDAMCKFLSGFYYLGLYSEIF 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 116 GLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQAPEDETICQI----NEEPGYVLFSALG 191
Cdd:cd15183   89 FIILLTIDRYLAIVHAVFALRARTVTFGIITSIITWALAILASMPCLYFFKSQWEFTHHTCSAhfprKSLIRWKRFQALK 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 192 ----SFYVPLTIILVMYCRVYVVakresrglksglktdksdseqvtlrIHRKnvPAEgsgvssaknkthfsvrllkfsRE 267
Cdd:cd15183  169 lnllGLILPLLVMIICYTGIINI-------------------------LLRR--PNE---------------------KK 200
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755547671 268 KKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPET--------VFKIVFWLGYLNSCINPIIYPCSSQEFKK 335
Cdd:cd15183  201 AKAVRLIFVITLLFFLLWTPYNLAAFVSAFQDVLFTPSCeqsqqldlALQVTEVIAYTHCCVNPVIYVFVGERFRK 276
7tmA_HCAR1-3 cd15201
hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G ...
32-337 1.83e-15

hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Hydroxycarboxylic acid receptor (HCAR) subfamily, a member of the class A G-protein coupled receptors (GPCRs), contains three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, or nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2 or GPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. Because nicotinic acid is capable of stimulating HCAR2 at higher concentrations only (in the range of sub-micromolar concentration), it is unlikely that nicotinic acts as a physiological ligand of HCAR2. All three receptors are expressed in adipocytes and mediate anti-lipolytic effects in fat cells through G(i) type G protein-dependent inhibition of adenylate cyclase.


Pssm-ID: 320329 [Multi-domain]  Cd Length: 281  Bit Score: 76.24  E-value: 1.83e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  32 ILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLtSTVLPFSAIFEILG-YWAFGRVFCNIWAAVDVLCC 110
Cdd:cd15201    6 VLILEFVLGLLGNGLALWIFCFHLKSWKSSTVYLFNLAVADFLL-IICLPFRTDYYLRGkHWKFGDIPCRIVLFMLAMNR 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 111 TASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQAPEDETICQ---INEEPGYVL- 186
Cdd:cd15201   85 AGSIFFLTAVAVDRYFRVVHPHHRINSISVRKAAIIACGLWLLTIAMTVYLLTKKHLFPRGNATQCEsfnICTGTDSSSn 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 187 ---FSALGSFYVPLTIILvmYCrvyvvakresrglksglktdksdSEQVTLRIHRKNvpaegsgvssaknkthfsvrLLK 263
Cdd:cd15201  165 wheAMFLLEFFLPLAIIL--YC-----------------------SVRIIWQLRGRQ--------------------LDR 199
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 264 FSREKKAAKTLGIVVGCFVLCWLP--------FFLVMPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKK 335
Cdd:cd15201  200 HAKIKRAVQFIMVVAIVFIICFLPsnvtriaiWILKHTSNEDCQYYRSVDLAFYITISFTYFNSMLDPVVYYFSSPSFKN 279

                 ..
gi 755547671 336 AF 337
Cdd:cd15201  280 FY 281
7tmA_Encephalopsin cd15078
encephalopsins (opsin-3), member of the class A family of seven-transmembrane G ...
28-335 1.86e-15

encephalopsins (opsin-3), member of the class A family of seven-transmembrane G protein-coupled receptors; Encephalopsin, also called Opsin-3 or Panopsin, is a mammalian extra-retinal opsin that is highly localized in the brain. It is thought to play a role in encephalic photoreception. Encephalopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320206 [Multi-domain]  Cd Length: 279  Bit Score: 76.41  E-value: 1.86e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  28 LLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDV 107
Cdd:cd15078    2 LLALLIATIGFLGVCNNLLVLILYYKFKRLRTPTNLLLVNISLSDLLVSLLGVTFTFMSCVRGRWVFDVAGCVWDGFSNS 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 108 LCCTASIMGLCIISIDRYIGVSyplrYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQAPEDETI-CQIN------E 180
Cdd:cd15078   82 LFGIVSIMTLTVLAYERYIRVV----HAKVVNFSWSWRAITYIWLYSLAWTGAPLLGWNRYTLEVHGLgCSFDwkskdpN 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 181 EPGYVLFSALGSFYVPLTIIlvMYCRVYVVakresrglksglktdksdseqVTLRIHRknvpaegsgvsSAKN-KTHFSV 259
Cdd:cd15078  158 DTSFVLLFFLGCLVVPLGIM--AYCYGHIL---------------------YEIRMLR-----------SVEDlQTFQVI 203
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755547671 260 RLLKFsrEKKAAKTLGIVVGCFVLCWLPFFLV-MPIGSFFPNFKPPeTVFKIVFWLGYLNSCINPIIYPCSSQEFKK 335
Cdd:cd15078  204 KILKY--EKKVAKMCLLMISTFLICWMPYAVVsLLVTSGYSKLVTP-TIAIIPSLFAKSSTAYNPVIYIFMIRKFRQ 277
7tmA_BK-2 cd15381
bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled ...
36-335 1.98e-15

bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320503 [Multi-domain]  Cd Length: 284  Bit Score: 76.34  E-value: 1.98e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  36 LIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTvLPFSAIFEILGY-WAFGRVFCNIWAAVDVLCCTASI 114
Cdd:cd15381   10 IFVLGTIENAFVLIVFCLHKSSCTVAEIYLGNLAAADLLLVCC-LPFWAINISNGFnWPFGEFLCKSVNAVIYMNLYSSI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 115 MGLCIISIDRYIGVsypLRYPTIVTQRRGVRA---LLCVWALSLVISIgPLFGWR--QQAPE-DETICQIN-EEPGYVLF 187
Cdd:cd15381   89 YFLMMVSIDRYLAL---VKTMSSGRMRRPACAklnCLIIWMFGLLMST-PMIVFRtvMYFPEyNITACVLDyPSEGWHVA 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 188 SAL----GSFYVPLTIIlvMYCRVYVvakresrglksgLKTDKSDSEQvtlrihrknvpaegsgvssaknkthfsvRLLK 263
Cdd:cd15381  165 LNIllnvVGFLIPLSII--TFCSTQI------------IQVLRNNKMQ----------------------------KFKE 202
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 264 FSREKKAAKTLGIVVGCFVLCWLPF----FL----VMPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKK 335
Cdd:cd15381  203 IQTERKATVLVLAVLLMFFICWLPFhiftFLdtlhKLGLISGCRWEDILDIGTQIATFLAYSNSCLNPLLYVIVGKHFRK 282
7tmA_LTB4R1 cd15121
leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of ...
28-329 2.07e-15

leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320249 [Multi-domain]  Cd Length: 278  Bit Score: 76.39  E-value: 2.07e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  28 LLGVILGGL-IIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVAD--LLLTStvlPFSAIFEILGYWAFGRVFCNIWAA 104
Cdd:cd15121    1 QLGIAILSLaFILGFPGNLFVVWSVLCRMKKRSVTCILVLNLALADaaVLLTA---PFFLHFLSGGGWEFGSVVCKLCHY 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 105 VDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIgPLFGWRQQAPE--DETICQ-INEE 181
Cdd:cd15121   78 VCGVSMYASIFLITLMSMDRCLAVAKPFLSQKMRTKRSVRALLLAIWIVAFLLSL-PMPFYRTVLKKniNMKLCIpYHPS 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 182 PGYV----LFSALGSFYVPLTIILVMYCrvyVVAKResrglksglktdksdseqvtlrihrknvpaegsgvssaknkthf 257
Cdd:cd15121  157 VGHEafqyLFETITGFLLPFTAIVTCYS---TIGRR-------------------------------------------- 189
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 258 sVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLV--MPIGSFFPNFKPPETVFK-------IVFWLGYLNSCINPIIYPC 328
Cdd:cd15121  190 -LRSARFRRKRRTNRLVVLIIATFALFWLPYHVVnlIQVAGALQNQAGNASVLKaaklarpNVTALAFLSSSVNPVLYAF 268

                 .
gi 755547671 329 S 329
Cdd:cd15121  269 A 269
7tmA_NPBWR cd15087
neuropeptide B/W receptors, member of the class A family of seven-transmembrane G ...
27-337 2.10e-15

neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide B/W receptor 1 and 2 are members of the class A G-protein coupled receptors that bind the neuropeptides B and W, respectively. NPBWR1 (previously known as GPR7) is expressed predominantly in cerebellum and frontal cortex, while NPBWR2 (previously known as GPR8) is located mostly in the frontal cortex and is present in human, but not in rat and mice. These receptors are suggested to be involved in the regulation of food intake, neuroendocrine function, and modulation of inflammatory pain, among many others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320215 [Multi-domain]  Cd Length: 282  Bit Score: 76.32  E-value: 2.10e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTsTVLPFSAIFEILGYWAFGRVFCNIWAAVD 106
Cdd:cd15087    1 VALPVIYSVICAVGLTGNTAVIYVILRAPKMKTVTNVFILNLAIADDLFT-LVLPINIAEHLLQQWPFGELLCKLILSID 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIGVSYPLRYPTIV--TQRRGVRALLCVWAL-SLVISIGPLFGWRQQAPEDETICQIN-EEP 182
Cdd:cd15087   80 HYNIFSSIYFLTVMSVDRYLVVLATVRSRRMPyrTYRAAKIVSLCVWLLvTIIVLPFTVFAGVYSNELGRKSCVLSfPSP 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 183 GYVLFSA------LGSFYVPLTIILVMYcrVYVVAKresrglksglktdksdseqvtLRIHRKNVPAEgsGVSSAKNKTH 256
Cdd:cd15087  160 ESLWFKAsriytlVLGFAIPVSTICILY--TMMLYK---------------------LRNMRLNSNAK--ALDKAKKKVT 214
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 257 FSVrllkfsrekkaaktLGIVVGCfVLCWLPFFL--VMPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFK 334
Cdd:cd15087  215 LMV--------------LVVLAVC-LFCWTPFHLstVVALTTDLPQTPLVIGISYFITSLSYANSCLNPFLYAFLDDSFR 279

                 ...
gi 755547671 335 KAF 337
Cdd:cd15087  280 KSF 282
7tmA_S1PR1_Edg1 cd15346
sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial ...
39-337 2.32e-15

sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial differentiation gene 1 (Edg1), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320468 [Multi-domain]  Cd Length: 277  Bit Score: 76.07  E-value: 2.32e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  39 FGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLL----LTSTVLPFSAIFEIL--GYWAF--GRVFCNIwaavdvlcc 110
Cdd:cd15346   13 FIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLagvaYTANLLLSGATTYKLtpTQWFLreGSMFVAL--------- 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 111 TASIMGLCIISIDRYIGVsYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWR--QQAPEDETICQINEEpGYVLFS 188
Cdd:cd15346   84 SASVFSLLAIAIERYITM-LKMKLHNGSNSFRSFLLISACWVISLILGGLPIMGWNciSALSSCSTVLPLYHK-HYILFC 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 189 ALgSFYVPLTIILVMYCRVYVVAKRESRGLksglktdksdseqvtlrIHRKNVpaEGSGVSSAKnkthfSVRLLkfsrek 268
Cdd:cd15346  162 TT-VFTLLLLSIVILYCRIYSLVRTRSRRL-----------------TFRKNI--RKASRSSEK-----SMALL------ 210
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755547671 269 kaaKTLGIVVGCFVLCWLPFFLVMPIgSFFPNFKPPETVFKIVFW--LGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15346  211 ---KTVIIVLSVFIACWAPLFILLLL-DVGCKVKTCSILFKAEYFlvLAVLNSATNPIIYTLTNKEMRRAF 277
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
38-334 2.94e-15

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 75.66  E-value: 2.94e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  38 IFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMGL 117
Cdd:cd15085   12 TFSIFNNVLVIAVTLKNPQLRNPINIFILNLSFSDLMMALCGTTIVTVTNYEGYFYLGDAFCIFQGFAVNYFGIVSLWSL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 118 CIISIDRYIGVSYPLRYPTIVTqRRGVRALLCVWALSLVISIGPLFGWRQQAPED-ETICQINEEP------GYVLFSAL 190
Cdd:cd15085   92 TLLAYERYNVVCKPMGGLKLST-KRGYQGLLFIWLFCLFWAVAPLFGWSSYGPEGvQTSCSIGWEErswsnySYLILYFL 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 191 GSFYVPLTIILVMYCRVyvvakresrgLKSGLKTDKSDSEQvtlriHRKNVPAEgsgvssaknkthfsvrllkfsrEKKA 270
Cdd:cd15085  171 MCFVIPVAIIGFSYGNV----------LRSLHKLNKKIEQQ-----GGKNCPEE----------------------EERA 213
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755547671 271 AKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFK 334
Cdd:cd15085  214 VIMVLAMVIAFLICWLPYTVFALIVVVNPELSISPLAATMPTYFAKTSPVYNPIIYIFLNKQFR 277
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
27-337 3.83e-15

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 75.56  E-value: 3.83e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTvLPFSAIFEILG-YWAFGRVFCNIWAAV 105
Cdd:cd15162    1 VFLPAVYTLVFVVGLPANGMALWVLLFRTKKKAPAVIYMANLAIADLLLVIW-LPFKIAYHIHGnNWIFGEALCRLVTVA 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 106 DVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIgPLFGWRQ--QAPE-DETIC------ 176
Cdd:cd15162   80 FYGNMYCSILLLTCISIDRYLAIVHPMGHRRLRARRYALGTCLAIWLLALLVTL-PLYLVKQtiFLPAlDITTChdvlpe 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 177 --QINEEPGYVLFSALGSFYVPLtiILVMYCRVYVVakresRGLksglktdksdseqvtlrihrknvpAEGSGVSSAKNK 254
Cdd:cd15162  159 qlLVGDWFYYFLSLAIVGFLIPF--ILTASCYVATI-----RTL------------------------AALEDENSEKKK 207
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 255 THfsvrllkfsrekkAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPETV---FKIVFWLGYLNSCINPIIYPCSSQ 331
Cdd:cd15162  208 KR-------------AIKLAATVLAIFIICFAPSNLLLLAHYSLISSSGTGHLyfaYLLALCLSTLNSCIDPFIYYFVSK 274

                 ....*.
gi 755547671 332 EFKKAF 337
Cdd:cd15162  275 EFRDHV 280
7tmA_LPAR4 cd15155
lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G ...
28-337 5.25e-15

lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 4 (LPAR4) is a G protein-coupled receptor that binds and is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively found in serum. Phylogenetic analysis of the class A GPCRs shows that LAPR4 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(12/13) proteins, leading to neurite retraction and stress fiber formation, whereas coupling to G(q) protein leads to increases in calcium levels.


Pssm-ID: 320283 [Multi-domain]  Cd Length: 283  Bit Score: 74.96  E-value: 5.25e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  28 LLGVILGGLIIFGVLGNIlVILSVACHR-HLHSVTHYYIVNLAVADLLLTSTvLPFSAIFEILGYWAFGRVFCNIWAAVD 106
Cdd:cd15155    2 LYGAVYSVVFILGLITNC-ASLFVFCFRmKMRNETAIFMTNLAVSDLLFVFT-LPFKIFYNFNRHWPFGDSLCKISGTAF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQAPEDETIC----QINEEP 182
Cdd:cd15155   80 LTNIYGSMLFLTCISVDRFLAIVYPFRSRTIRTRRNSAIVCAGVWILVLSGGISASLFSTTNVSNTSTTCfegfSKSIWK 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 183 GYV----LFSALGSFYVPLtiILVMYCrvyvvakresrglksglktdksdsEQVTLRIHRKnvPAEGSGVSSAKnkthfs 258
Cdd:cd15155  160 TYLskitIFIEVVGFIIPL--LLNLTC------------------------SSLVLRTLRK--PATLSQIGTNK------ 205
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 259 vrllkfsreKKAAKTLGIVVGCFVLCWLPF----FLVMPIGS------FFPNFKppETVFKIVFWLGYLNSCINPIIYPC 328
Cdd:cd15155  206 ---------EKVLKMILVHVAIFVVCFVPYnsilFLYALVRSqaiancGVERFA--RTMYPITLCLATLNCCFDPFVYYF 274

                 ....*....
gi 755547671 329 SSQEFKKAF 337
Cdd:cd15155  275 TSESFQKSF 283
7tmA_GPR39 cd15135
G protein-coupled receptor 39, member of the class A family of seven-transmembrane G ...
36-337 5.48e-15

G protein-coupled receptor 39, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR39 is an orphan G protein-coupled receptor that belongs to the growth hormone secretagogue and neurotensin receptor subfamily. GPR39 is expressed in peripheral tissues such as pancreas, gut, gastrointestinal tract, liver, kidney as well as certain regions of the brain. The divalent metal ion Zn(2+) has been shown to be a ligand capable of activating GPR39. Thus, it has been suggested that GPR39 function as a G(q)-coupled Zn(2+)-sensing receptor which involved in the regulation of endocrine pancreatic function, body weight, gastrointestinal mobility, and cell death.


Pssm-ID: 320263 [Multi-domain]  Cd Length: 320  Bit Score: 75.60  E-value: 5.48e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  36 LIIFGVLGNILVILSVACHRH----LHSVTHYyIVNLAVADLLLTSTVLP---FSAIFEILGyWAFGRVFCNIWAAVDVL 108
Cdd:cd15135   10 ILVAGILGNSATIKVTQVLQKkgylQKSVTDH-MVSLACSDLLVLLLGMPvelYSAIWDPFA-TPSGNIACKIYNFLFEA 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 109 CCTASIMGLCIISIDRYIGVSYPLRYPTiVTQRRGVRALLCVWALSLVISIGPLFG------------------WRQQAP 170
Cdd:cd15135   88 CSYATILNVATLSFERYIAICHPFKYKA-LSGSRVRLLICFVWLTSALVALPLLFAmgtedpleafpsyrgtrhHCQDQK 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 171 EDETICQiNEEPGYVLFSAlgSFYVPLTIILVMYCRVYVVAKRESRglksglktdksdseqvTLRIHRKNVPAEGSGVSS 250
Cdd:cd15135  167 SNLTICT-SLSSKWTVFQA--SIFSAFVLYLLVLASVAFMCRRMMR----------------ALMGSKKGAVAVKGPGGS 227
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 251 AKNKTHFSVRLLKFSReKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPETVFKIVFWLG-------YLNSCINP 323
Cdd:cd15135  228 VQLLRKHESAEGKTAR-KQTILFLGLIVGTLAVCWMPNQIRRIMAAAKPKDDWTRSYFRAYIILLpiadtffYLSSVLNP 306
                        330
                 ....*....|....
gi 755547671 324 IIYPCSSQEFKKAF 337
Cdd:cd15135  307 LLYNLSSQQFRSVF 320
7tmA_CCR8 cd15187
CC chemokine receptor type 8, member of the class A family of seven-transmembrane G ...
27-335 5.52e-15

CC chemokine receptor type 8, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR8, the receptor for the CC chemokines CCL1 and CC16, is highly expressed on allergen-specific T-helper type 2 cells, and is implicated in the pathogenesis of human asthma. CCL1- and CCR8-expressing CD4+ effector T lymphocytes are shown to have a critical role in lung mucosal inflammatory responses. CCR8 is also a functional receptor for CCL16, a liver-expressed CC chemokine that involved in attracting lymphocytes, dendritic cells, and monocytes. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320315 [Multi-domain]  Cd Length: 276  Bit Score: 74.84  E-value: 5.52e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTvLPFSAIFeILGYWAFGRVFCNIWAAVD 106
Cdd:cd15187    1 LFLPVLYCLLFVFGLLGNSLVIWVLVACKKLRSMTDVYLLNLAASDLLFVFS-LPFQAYY-LLDQWVFGNAMCKIVSGAY 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIgPLFGWRQQAPEDETICQINEEPG--- 183
Cdd:cd15187   79 YIGFYSSMFFITLMSIDRYLAIVHAVYALKVRTASHGTILSLALWLVAILASV-PLLVFYQVASEDGRLQCIPFYPGqgn 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 184 -YVLFS-----ALGsFYVPLTIILVMYCRVYvvakRESRGLKSglktdksdseqvtlrihrknvpaegsgvssaKNKThf 257
Cdd:cd15187  158 sWKVFTnfevnILG-LLIPFSILIFCYHNIL----RNLRRCHN-------------------------------QNKT-- 199
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 258 svrllkfsrekKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFP--------NFKPPETVFKIVFWLGYLNSCINPIIYPCS 329
Cdd:cd15187  200 -----------KAIKLVFIVVIVFFLFWTPFNVVLFLDSLHSlhiidgcqNSQRLTLALHLTETISFTHCCLNPVIYAFV 268

                 ....*.
gi 755547671 330 SQEFKK 335
Cdd:cd15187  269 GEKFKK 274
7tmA_V1bR cd15386
vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
32-326 5.69e-15

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320508 [Multi-domain]  Cd Length: 302  Bit Score: 75.22  E-value: 5.69e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  32 ILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTS-TVLPfSAIFEILGYWAFGRVFCNIWAAVDVLCC 110
Cdd:cd15386    6 VLAAILVVATAGNLAVLLAMYRMRRKMSRMHLFVLHLALTDLVVALfQVLP-QLIWEITYRFQGPDLLCRAVKYLQVLSM 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 111 TASIMGLCIISIDRYIGVSYPLRypTIVTQRRGVRALLCV-WALSLVISIGPLFGWrqqapedeTICQINEEPG------ 183
Cdd:cd15386   85 FASTYMLIMMTVDRYIAVCHPLR--TLQQPSRQAYLMIGAtWLLSCILSLPQVFIF--------SLREVDQGSGvldcwa 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 184 ----------YVLFSALGSFYVPLTIILVMYCrvyVVAKRESRGLKsgLKTDKSDSEQVTLRihRKNVPaegSGVSSAKN 253
Cdd:cd15386  155 dfgfpwgakaYITWTTLSIFVLPVAILIVCYS---LICYEICKNLK--GKTQTSRSEGGGWR--TQGMP---SRVSSVRT 224
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755547671 254 KTHFSVRLLKFsrekkaakTLGIVVGcFVLCWLPFFLVMpIGSFF----PNFKPPETVFKIVFWLGYLNSCINPIIY 326
Cdd:cd15386  225 ISRAKIRTVKM--------TFVIVLA-YIACWAPFFSVQ-MWSVWdenaPDEDSSDFAFTITMLLASLSSCCNPWIY 291
PHA02638 PHA02638
CC chemokine receptor-like protein; Provisional
14-334 1.27e-14

CC chemokine receptor-like protein; Provisional


Pssm-ID: 165021 [Multi-domain]  Cd Length: 417  Bit Score: 75.43  E-value: 1.27e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  14 CTHPpaqvNISKAILLGVILggLIIFGVLGNILVILsVACHRHLHSVTHYYIVNLAVADLLLTSTvLPFsAIFEILGYWA 93
Cdd:PHA02638  92 CMYP----SISEYIKIFYII--IFILGLFGNAAIIM-ILFCKKIKTITDIYIFNLAISDLIFVID-FPF-IIYNEFDQWI 162
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  94 FGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWR------Q 167
Cdd:PHA02638 163 FGDFMCKVISASYYIGFFSNMFLITLMSIDRYFAILYPISFQKYRTFNIGIILCIISWILSLIITSPAYFIFEasniifS 242
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 168 QAPEDETI----CQI---NEEPGYVLFSALGSFYVP-----LTIILVMYCRVYVVAKresrglksglktdksdseqvtlr 235
Cdd:PHA02638 243 AQDSNETIsnyqCTLiedNEKNNISFLGRILQFEINilgmfIPIIIFAFCYIKIILK----------------------- 299
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 236 ihrknvpaegsgvssaknkthfsVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFpNFKPPETVFKI----V 311
Cdd:PHA02638 300 -----------------------LKQLKKSKKTKSIIIVSIIIICSLICWIPLNIVILFATMY-SFKGFNSIISEhicgF 355
                        330       340       350
                 ....*....|....*....|....*....|...
gi 755547671 312 FWLGY----------LNSCINPIIYPCSSQEFK 334
Cdd:PHA02638 356 IKLGYammlaeaislTHCCINPLIYTLIGENFR 388
7tmA_NPY6R cd15396
neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G ...
27-335 1.47e-14

neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320518 [Multi-domain]  Cd Length: 293  Bit Score: 74.10  E-value: 1.47e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVD 106
Cdd:cd15396    1 FLLIIAYSVVTIVGLFGNLCLITIIKKQKEEHNVTNILIANLSLSDVLVCVMCIPFTAVYTLMDHWIFGETMCKLTSFVQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIGVSYPLRY-PTIVTQRRGVralLCVWALSLVISIgPLFGWRQQAPE-------------D 172
Cdd:cd15396   81 SVSVSVSIFSLVLIAIERYQLIVNPRGWkPSASHAYWGI---VLIWLFSLMISI-PFLIFHQLTDEpfrnlsshsdfykD 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 173 ETIC--QINEEPGYVLFSA---LGSFYVPLTIILVMYCRVYVVAKRESRglksglKTDKsdseqvtlriHRKNVPaegsg 247
Cdd:cd15396  157 KVVCieAWPSETERLIFTTsllVFQYFVPLGFIFICYLKIFVCLKKRNS------KIDR----------MRENES----- 215
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 248 vssaknkthfsvrllKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPP---ETVFKIVFWLGYLNSCINPI 324
Cdd:cd15396  216 ---------------RLSENKRINTMLISIVVTFAACWLPLNIFNVVFDWNHEVLMSchhNLVFTLCHLVAMVSTCINPI 280
                        330
                 ....*....|.
gi 755547671 325 IYPCSSQEFKK 335
Cdd:cd15396  281 FYGFLNKNFQK 291
7tmA_GRPR cd15124
gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
32-337 3.53e-14

gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The gastrin-releasing peptide receptor (GRPR) is a G-protein coupled receptor whose endogenous ligand is gastrin releasing peptide. GRP shares high sequence homology with the neuropeptide neuromedin B in the C-terminal region. This receptor is high glycosylated and couples to a pertussis-toxin-insensitive G protein of the family of Gq/11, which leads to the activation of phospholipase C. Gastrin-releasing peptide (GRP) is a potent mitogen for neoplastic tissues and involved in regulating multiple functions of the gastrointestinal and central nervous systems. These include the release of gastrointestinal hormones, the contraction of smooth muscle cells, and the proliferation of epithelial cells. GRPR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320252 [Multi-domain]  Cd Length: 293  Bit Score: 73.01  E-value: 3.53e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  32 ILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCT 111
Cdd:cd15124    6 VYGIIILIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLVTCAPVDASRYLADEWLFGRVGCKLIPFIQLTSVG 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 112 ASIMGLCIISIDRYIGVSYPLRYPTI-VTQRRGVRALLcVWALSLVISIgPLFGWRQQAPEDETicQINE---------- 180
Cdd:cd15124   86 VSVFTLTALSADRYKAIVRPMDIQASnALMKICLKAAL-IWILSMLLAI-PEAVFSDLHPFYDK--STNKtfvscapyph 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 181 ----EPGYVLFSALGSFYV-PLTIILVMYcrvYVVAKresrglksglktdksdseqvTLRIHRKNVPAEGSgvssaknkT 255
Cdd:cd15124  162 snelHPKIHSMASFLIFYViPLSIISVYY---YFIAK--------------------NLIRSAYNLPVEGN--------V 210
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 256 HfsVRLLKFSReKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFfpNFKPPETVFK------IVFWLGYLNSCINPIIYPCS 329
Cdd:cd15124  211 H--VRRQIESR-KRLAKTVLVFVGLFAFCWLPNHIIYLYRSY--HYSEVDTSMLhfvssiCARILAFTNSCVNPFALYLL 285

                 ....*...
gi 755547671 330 SQEFKKAF 337
Cdd:cd15124  286 SKSFRKQF 293
7tmA_CCR10 cd15177
CC chemokine receptor type 10, member of the class A family of seven-transmembrane G ...
36-178 4.54e-14

CC chemokine receptor type 10, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR10 is a homeostatic receptor specific for two C-C motif chemokines, CCL27 and CCL28. Activation of CCR10 by its two ligands mediates diverse activities, ranging from leukocyte trafficking to skin cancer. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341332 [Multi-domain]  Cd Length: 280  Bit Score: 72.11  E-value: 4.54e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  36 LIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTvLPFSAIFEILGyWAFGRVFCNIWAAVDVLCCTASIM 115
Cdd:cd15177   10 VFVLGLVGNGLVLATHTRYRRLRSMTDVYLLNLALADLLLLLT-LPFAAAETLQG-WIFGNAMCKLIQGLYAINFYSGFL 87
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755547671 116 GLCIISIDRYIGV--SYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQAPEDETICQI 178
Cdd:cd15177   88 FLTCISVDRYVVIvrATSAHRLRPKTLFYSVLTSLIVWLLSILFALPQLIYSRVENRSELSSCRM 152
7tmA_GPR19 cd15008
G protein-coupled receptor 19, member of the class A family of seven-transmembrane G ...
28-335 5.17e-14

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 19 is an orphan receptor that is expressed predominantly in neuronal cells during mouse embryogenesis. Its mRNA is found frequently over-expressed in patients with small cell lung cancer. GPR19 shares a significant amino acid sequence identity with the D2 dopamine and neuropeptide Y families of receptors. Human GPR19 gene, intronless in the coding region, also has a distribution in brain overlapping that of the D2 dopamine receptor gene, and is located on chromosome 12. GPR19 is a member of the class A family of GPCRs, which represents a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320137 [Multi-domain]  Cd Length: 275  Bit Score: 72.17  E-value: 5.17e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  28 LLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDV 107
Cdd:cd15008    1 AASLVFGVLWLVSVFGNSLVCLVIHRSRRTQSTTNYFVVSMACADLLLSVASAPFVLLQFTSGRWTLGSAMCKLVRYFQY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 108 LCCTASIMGLCIISIDRYIGVSYPLRYPtiVTQRRGVRALLCVWALSLVIsIGPLFGWRQQAPEDET---ICQINEEPGY 184
Cdd:cd15008   81 LTPGVQIYVLLSICVDRFYTIVYPLSFK--VSREKAKKMIAASWLFDAAF-VSPALFFYGSNWGPHCnffLPDSWDGAAY 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 185 VLFSALGSFYVPLTIILVMYCRVYVVAKRESrglksglktdksdSEQVTLRIHRKNVPaegsgvssaknkthfsvrllkf 264
Cdd:cd15008  158 AIIHLLVGFLVPSILIILFYQKVIKYIWRIG-------------TDGRTVRRTMNIVP---------------------- 202
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755547671 265 sREK-KAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKK 335
Cdd:cd15008  203 -RTKvKTIKMFLMLNSMFLLSWLPFYVVQLWHPRESDYRQSSLVFLAVTWISFSSSASKPTLYSVYNANFRR 273
7tmA_LPAR cd15101
lysophosphatidic acid receptor subfamily, member of the class A family of seven-transmembrane ...
38-337 7.63e-14

lysophosphatidic acid receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 341325 [Multi-domain]  Cd Length: 274  Bit Score: 71.39  E-value: 7.63e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  38 IFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLlltstvlpFSAIFEILGYWAFG----RVFCNIWAAVDVL---CC 110
Cdd:cd15101   12 IFIMLANLLVIAAIYKNRRFHFPIYYLLANLAAADF--------FAGLAYFFLMFNTGpntrRLTVSTWFLRQGLldtSL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 111 TASIMGLCIISIDRYIGVsYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWrqqapedETICQI----NEEP---- 182
Cdd:cd15101   84 TASVANLLAIAVERHISV-MRMQLHSRLSNRRVVVLIVLVWTMAIVMGAIPSVGW-------NCLCAIdacsNMAPlysr 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 183 GYVLFSALGSFyVPLTIILVMYCRVYVVAKRESRGLksglktdksdSEQVTLRIHRKNVPAegsgvssaknkthfsvrll 262
Cdd:cd15101  156 SYLVFWAISNL-VTFLVMVVVYARIFVYVRRRTNRM----------SPHTSGSIRNRDTMM------------------- 205
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755547671 263 kfsrekKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15101  206 ------SLLKTVVIVLGAFVVCWTPGLVVLLLDGLCCRQCNVLAVEKFFLLLAEFNSAVNPIIYSYRDKEMSGTF 274
7tmA_LPAR2_Edg4 cd15342
lysophosphatidic acid receptor subtype 2 (LPAR2 or LPA2), also called Endothelial ...
31-337 8.04e-14

lysophosphatidic acid receptor subtype 2 (LPAR2 or LPA2), also called Endothelial differentiation gene 4 (Edg4), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320464 [Multi-domain]  Cd Length: 274  Bit Score: 71.37  E-value: 8.04e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  31 VILGGLI-IFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLL--LTSTVLPFSAifeilGYWAfGRVFCNIWAAVDV 107
Cdd:cd15342    4 VALGLTVsVIVLLTNLLVIAAIFINRRFHYPIYYLLGNLAAADLFagVAYLFLMFHT-----GPWT-AKLSLYQWFLRQG 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 108 L---CCTASIMGLCIISIDRYIGVsYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWrqqapedETICQINE---- 180
Cdd:cd15342   78 LldtSLTASVANLLAIAVERHQTI-FTMQLHSKMSNQRVVILIFGIWMVALILGLIPAMGW-------NCLCDLKRcstm 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 181 ----EPGYVLFSALGSFYVpLTIILVMYCRVYVVAKRESRGLksglktdksdSEQVTLRI-HRKNVpaegsgvssaknkt 255
Cdd:cd15342  150 aplySRSYLVFWALSNLLT-FLIMVAVYTRIFIYVRRKSQRM----------SEHHSSHPrYRETV-------------- 204
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 256 hfsVRLLKfsrekkaakTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKK 335
Cdd:cd15342  205 ---LGLMK---------TVVIILGAFVVCWTPGQVVLLLDGLGCESCNVLAYEKYFLLLAEINSLVNPIVYSYRDKEMRK 272

                 ..
gi 755547671 336 AF 337
Cdd:cd15342  273 TF 274
7tmA_CCR9 cd15174
CC chemokine receptor type 9, member of the class A family of seven-transmembrane G ...
38-336 8.53e-14

CC chemokine receptor type 9, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR9 is a homeostatic receptor specific for CCL25 (formerly known as thymus expressed chemokine) and is highly expressed on both immature and mature thymocytes as well as on intestinal homing T Lymphocytes and mucosal Lymphocytes. In cutaneous melanoma, activation of CCR9-CCL25 has been shown to stimulate metastasis to the small intestine. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 320302 [Multi-domain]  Cd Length: 280  Bit Score: 71.32  E-value: 8.53e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  38 IFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTvLPFSAIFEILGyWAFGRVFCNIWAAVDVLCCTASIMGL 117
Cdd:cd15174   12 LVGAVGNSLVVLIYTYYRRRKTMTDVYLLNLAIADLLFLCT-LPFWATAASSG-WVFGTFLCKVVNSMYKINFYSCMLLL 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 118 CIISIDRYIGVSYPLRYPTIVTQRRGVRALLC--VWALSLVISIGPLFGWRQQAPEDETICQINEEPGY-----VLFSAL 190
Cdd:cd15174   90 TCISVDRYIAIVQATKAHNSKNKRLLYSKLVCffVWLLSTILSLPEILFSQSKEEESVTTCTMVYPSNEsnrfkVAVLAL 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 191 G---SFYVPLTIILVMYCRVyvvakresrglksglktdksdseqvtlrihrknvpaegsgvssaknkTHFSVRLLKFSRE 267
Cdd:cd15174  170 KvtvGFFLPFVVMVICYTLI-----------------------------------------------IHTLLQAKRFQKH 202
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755547671 268 kKAAKTLGIVVGCFVLCWLPF--FLVMPIGSFFPNF-------KPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKA 336
Cdd:cd15174  203 -KALKVIIAVVTVFVLSQLPYnsILLIKTINAYNITitdcatsQNLDIAGQVTQSIAFLHSCLNPFLYVFVGVRFRKD 279
7tmA_V1aR cd15385
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
32-326 1.03e-13

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320507 [Multi-domain]  Cd Length: 301  Bit Score: 71.39  E-value: 1.03e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  32 ILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTS-TVLPfSAIFEILGYWAFGRVFCNIWAAVDVLCC 110
Cdd:cd15385    6 VLAVIFAVAVIGNSSVLLALYKTKKKASRMHLFIKHLSLADLVVAFfQVLP-QLCWDITYRFYGPDFLCRIVKHLQVLGM 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 111 TASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVrALLCVWALSLVISIGPLFGWRQQAPEDETI---CQIN-EEP---- 182
Cdd:cd15385   85 FASTYMLVMMTADRYIAICHPLKTLQQPTKRSYL-MIGSAWALSFILSTPQYFIFSLSEIENGSGvydCWANfIVPwgik 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 183 GYVLFSALGSFYVPLTIILVMY-CRVYVVakreSRGLKSGLKTDKSDSEqvtlrihRKNVPAeGSGVSSAKNKTHFSVRL 261
Cdd:cd15385  164 AYITWITISIFVVPVIILLTCYgFICYNI----WRNIKCKTRRGLSDNA-------LKNILL-AVCVSSVKTISRAKIRT 231
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755547671 262 LKFsrekkaakTLGIVVGcFVLCWLPFFLVMPIGSFFPNFKPPE---TVFKIVFWLGYLNSCINPIIY 326
Cdd:cd15385  232 VKM--------TFVIVLA-YIVCWAPFFTIQMWSVWDQNFPWDEsenTAVTITALLASLNSCCNPWIY 290
7tmA_S1PR5_Edg8 cd15348
sphingosine-1-phosphate receptor subtype 5 (S1PR5 or S1P5), also called endothelial ...
38-336 1.08e-13

sphingosine-1-phosphate receptor subtype 5 (S1PR5 or S1P5), also called endothelial differentiation gene 8 (Edg8), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320470 [Multi-domain]  Cd Length: 277  Bit Score: 71.01  E-value: 1.08e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  38 IFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLL---------LTSTVLPFSaIFEILGYWAFGRVFCNIwaavdvl 108
Cdd:cd15348   12 AFIVLENLIVLLALWRNKKFHSPMFYLLGSLTLSDLLagaayaaniLMSGANTLK-LTPALWFLREGGVFITL------- 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 109 ccTASIMGLCIISIDRYIGVSYPLRYPTivtQRRGVRALL--CVWALSLVISIGPLFGWRQQAPEDE--TICQINEEpGY 184
Cdd:cd15348   84 --TASVFSLLAIAIERHITMVRMKPYPG---DKRGRMFLLigAAWLVSILLGVLPILGWNCLGNLDAcsTVLPLYAK-SY 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 185 VLFSALgSFYVPLTIILVMYCRVYVVAKRESRGLKSGLKTdksdseqvtlrihrknvpaegsgvssaknkthfSVRLLKF 264
Cdd:cd15348  158 ILFCIT-VFLAILAAIVVLYARIYRIVKANSQRLGALPTR---------------------------------KGRARRS 203
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755547671 265 SREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNfKPPETVFKIVFWLG--YLNSCINPIIYPCSSQEFKKA 336
Cdd:cd15348  204 QKYLALLKTVTIVLGTFVACWLPLFLLLLLDVSCPA-QACPVLLKADYFLGlaMINSLLNPIIYTLTSRDMRRA 276
7tmA_RNL3R2 cd15925
relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G ...
27-336 1.14e-13

relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R2 is also known as GPR100, GPR142, and relaxin family peptide receptor 4 (RXFP4). Insulin-like peptide 5 (INSL5) is an endogenous ligand for RNL3R2 and plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. RNL3R2 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation.


Pssm-ID: 320591 [Multi-domain]  Cd Length: 283  Bit Score: 71.06  E-value: 1.14e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSV-ACHRHLHSVTHYYIVNLAVADLLLTSTvLPFSAIFEILGY-WAFGRVFCNIWAA 104
Cdd:cd15925    1 ILVALAYGLVCAIGLLGNLAVMYLLrNCARRAPPPIDVFVFNLALADFGFALT-LPFWAVESALDFhWPFGGAMCKMVLT 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 105 VDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISI--------GPLFGWR---QQAPEDE 173
Cdd:cd15925   80 ATVLNVYASVFLLTAMSVTRYWVVASAAGPGTHLSTFWAKIITLALWAAALLATVptaifateGEVCGVElclLKFPSNY 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 174 TICQineepgYVLFSALGSFYVPLTIILVMYCRVYVVakresrglksglktdksdseqvtLRIHRKNvpaegsgvssAKN 253
Cdd:cd15925  160 WLGA------YHLQRVVVAFVVPLGVITTSYLLLLSF-----------------------LQQHKVN----------QNN 200
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 254 KthfsvrllkfSREKKAAKTLGIVVGCFVLCWLPF-----------FLVMPIGSFFPNFKppETVFKIVFWLGYLNSCIN 322
Cdd:cd15925  201 R----------QRQSVIARSVRLVVASFFLCWFPNhvvtfwgvlvkFRAVPWNSTFYFIH--TYVFPVTTCLAHSNSCLN 268
                        330
                 ....*....|....
gi 755547671 323 PIIYPCSSQEFKKA 336
Cdd:cd15925  269 PVLYCLMRREFRQA 282
7tmA_GPR1 cd15119
G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane ...
38-334 1.18e-13

G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 1 (GPR1) belongs to the class A of the seven transmembrane domain receptors. This is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1. GPR1 is most closely related to another chemerin receptor CMKLR1. In an in-vitro study, GPR1 has been shown to act as a co-receptor to allow replication of HIV viruses.


Pssm-ID: 320247 [Multi-domain]  Cd Length: 278  Bit Score: 70.93  E-value: 1.18e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  38 IFGVLGNILVILsVACHRHLHSVTHYYIVNLAVADLLLTsTVLPFSAIFEILGY-WAFGRVFCNIWAAVDVLCCTASIMG 116
Cdd:cd15119   12 VLGVPGNAIVIW-VTGFKWKKTVNTLWFLNLAIADFVFV-LFLPLHITYVALDFhWPFGVWLCKINSFVAVLNMFASVLF 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 117 LCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISiGPLFGWRQ--QAPEDETICQINEEPG----------- 183
Cdd:cd15119   90 LTVISLDRYISLAHPVWSHRYRTLKSALILCGIVWLSAAAIS-GPALYFRDtmELSINVTICFNNFHKHdgdlivmrhti 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 184 YVLFSALGSFYVPLTIILVMYcrvyvvakresrglksglktdksdsEQVTLRIHRKNVpaegsgvssaknkthfsVRLLK 263
Cdd:cd15119  169 LVWVRFFFGFLFPLLTMVVCY-------------------------SLLAIKVKRRTL-----------------LISSK 206
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755547671 264 FSRekkaakTLGIVVGCFVLCWLPF----FLVMPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFK 334
Cdd:cd15119  207 FFW------TISAVIVAFFVCWTPYhifsILELSIHHSSYLHNVLRAGIPLATSLAFINSCLNPILYVLIGKKFK 275
7tmA_SWS2_opsin cd15077
short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G ...
36-230 1.24e-13

short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 2 (SWS2), which mediates visual transduction in response to light at short wavelengths (violet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320205 [Multi-domain]  Cd Length: 280  Bit Score: 71.01  E-value: 1.24e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  36 LIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLT--STVLPFSAIFEIlgYWAFGRVFCNIWAAVDVLCCTAS 113
Cdd:cd15077   10 LVIAGFPINVLTIICTIKYKKLRSHLNYILVNLAVANLIVVcfGSTTAFYSFSQM--YFVLGPLACKIEGFTATLGGMVS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 114 IMGLCIISIDRYIGVSYPLRYPTIvtqrRGVRALL-CV--WALSLVISIGPLFGWRQQAPED----------ETICQINE 180
Cdd:cd15077   88 LWSLAVVAFERFLVICKPLGNFTF----RGTHAIIgCIatWVFGLAASLPPLFGWSRYIPEGlqcscgpdwyTTNNKWNN 163
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 755547671 181 EpGYVLFSALGSFYVPLTIILVMYCRVYVVAKRESRGLKSGLKTDKSDSE 230
Cdd:cd15077  164 E-SYVMFLFCFCFGVPLSIIVFSYGRLLLTLRAVAKQQEQSASTQKAERE 212
7tmA_GPR15 cd15194
G protein-coupled receptor 15, member of the class A family of seven-transmembrane G ...
27-328 1.98e-13

G protein-coupled receptor 15, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR15, also called as Brother of Bonzo (BOB), is an orphan G-protein coupled receptor that was originally identified as a co-receptor for human immunodeficiency virus. GPR15 is upregulated in patients with rheumatoid arthritis and shares high sequence homology with angiotensin II type AT1 and AT2 receptors; however, its endogenous ligand is unknown. GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation.


Pssm-ID: 320322 [Multi-domain]  Cd Length: 281  Bit Score: 70.27  E-value: 1.98e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTvLPFSAIFEI-LGYWAFGRVFCNIWAAV 105
Cdd:cd15194    1 GFLPILYCLVFLVGAVGNAILMGALVFKRGVRRLIDIFISNLAASDFIFLVT-LPLWVDKEVvLGPWRSGSFLCKGSSYI 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 106 DVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQAPEDETICQINE-EPGY 184
Cdd:cd15194   80 ISVNMYCSVFLLTCMSLDRYLAIVLPLVSRKFRTKHNAKVCCTCVWMLSCLLGLPTLLSRELKKYEEKEYCNEDAgTPSK 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 185 VLFSALG---SFYVPLTIILVMYCRVyvvakresrGLKSGLKTDKSDSEQVTLRihrknvpaegsgvssaknkthfsvrl 261
Cdd:cd15194  160 VIFSLVSlivAFFLPLLSILTCYCTI---------IWKLCHHYQKSGKHQKKLR-------------------------- 204
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755547671 262 lkfsrekKAAKTLGIVVGCFVLCWLPF--FLVMPIGSFFPNFKP--PETVFKIVFW----LGYLNSCINPIIYPC 328
Cdd:cd15194  205 -------KSIKIVFIVVAAFVFSWMPFnlFKALAIASGLQVEVTclPYTLAQLGMEvsapLAFANSCANPFIYYF 272
7tmA_GPBAR1 cd15905
G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G ...
26-292 2.06e-13

G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G-protein coupled bile acid receptor GPBAR1 is also known as BG37, TGR5 (Takeda G-protein-coupled receptor 5), M-BAR (membrane-type receptor for bile acids), and GPR131. GPBAR1 is highly expressed in the gastrointestinal tract, but also found at many other tissues including liver, colon, heart, skeletal muscle, and brown adipose tissue. GPBAR1 functions as a membrane-bound receptor specific for bile acids, which are the end products of cholesterol metabolism that facilitate digestion and absorption of lipids or fat-soluble vitamins. Bile acids act as liver-specific metabolic signaling molecules and stimulate liver regeneration by activating GPBAR1 and nuclear receptors such as the farnesoid X receptor (FXR). Upon bile acids binding, GPBAR1 activation causes release of the G-alpha(s) subunit and activation of adenylate cyclase. The increase in intracellular cAMP level then stimulates the expression of many genes via the PKA-mediated phosphorylation of cAMP-response element binding protein (CREB). Thus, GPAR1-signalling exerts various biological effects in immune cells, liver, and metabolic tissues. For example, GPBAR1 activation leads to enhanced energy expenditure in brown adipose tissue and skeletal muscle; stimulation of glucagon-like peptide-1 (GLP-1) production in enteroendocrine L-cells; and inhibition of pro-inflammatory cytokine production in macrophages and attenuation of atherosclerosis development. GPBAR1 is a member of the class A rhodopsin-like family of GPCRs, which comprises receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands.


Pssm-ID: 320571 [Multi-domain]  Cd Length: 272  Bit Score: 70.17  E-value: 2.06e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  26 AILLGVILGGLIIFGvlgNILVILSVACHRHLHSVTHYYIVNLAVADLLlTSTVLPFSAIFEI---LGYWA--FGRVFCN 100
Cdd:cd15905    1 IFWLSVPLSSLIIFA---NLFIILGIACNRKLHNTANYFFLSLLLADLL-TGVALPFIPGMSNesrRGYHSclFVYVAPN 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 101 IWAavdvlccTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQAPEDETICQINE 180
Cdd:cd15905   77 FLF-------LSFLANLLMVHYERYLCIVYPLQYHNFWVHRWVPLALLLTWALPLLFACLPALGWNNWTPGSNCSYKQVF 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 181 EPGYVLFSALGSFYVPLTIILVMYCRVYVVAKRESRGLKsglktdksdseqvtlRIHRKNVPAEGSGVSSAKNKTHfsvr 260
Cdd:cd15905  150 PAAYIYLEVYGLVLPSILAIAFMSVRVLAVARRQLQDIC---------------KLLRAVQRDGPSELEQQLNLRY---- 210
                        250       260       270
                 ....*....|....*....|....*....|..
gi 755547671 261 llkfsrekkaAKTLGIVVGCFVLCWLPFFLVM 292
Cdd:cd15905  211 ----------AKCIAGVSLTFLVCWVPYIAYL 232
7tmA_CCR6 cd15172
CC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
27-337 2.37e-13

CC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR6 is the only known receptor identified for the chemokine CCL20 (also known as macrophage inflammatory protein-3alpha, MIP-3alpha). CCR6 is expressed by all mature human B cells, effector memory T-cells, and dendritic cells found in the gut mucosal immune system. CCL20 contributes to recruitment of CCR6-expressing cells to Peyer's patches and isolated lymphoid follicles in the intestine, thereby promoting the assembly and maintenance of organized lymphoid structures. Also, CCL20 expression is highly inducible in response to inflammatory signals. Thus, CCL20 is involved in both inflammatory and homeostatic functions in the immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341330 [Multi-domain]  Cd Length: 281  Bit Score: 70.17  E-value: 2.37e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTvLPFSAIFEiLGYWAFGRVFCNIWAAVD 106
Cdd:cd15172    1 VFVPVIYSLICVVGLIGNSLVVITYAFYKRTKSMTDVYLLNMAIADILFVLT-LPFWAVYE-AHQWIFGNFSCKLLRGIY 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIGV-----SYPLRYPTIVTQRrgvraLLC--VWALSLVISiGPLFGWRQQ---APEDETIC 176
Cdd:cd15172   79 AINFYSGMLLLACISVDRYIAIvqatkSFRLRSRTLAYSK-----LICaaVWLLAILIS-LPTFIFSEVydfGLEEQYVC 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 177 QI----NEEPGYVLFSALGS-----FYVPLTIILvmYCRVYVVakresrglksglktdksdseqVTLRihrknvpaegsg 247
Cdd:cd15172  153 EPkypkNSTAIMWKLLVLSLqvslgFFIPLLVMI--FCYSFII---------------------KTLL------------ 197
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 248 vsSAKNkthfsvrllkfSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFfpNFKPPET---------VFKIVFWLGYLN 318
Cdd:cd15172  198 --QAQN-----------SQRHKAVRVVVAVVLVFLVCQVPYNIVLLIEAI--NLGEQQScssekavayAKTITECLAFFH 262
                        330
                 ....*....|....*....
gi 755547671 319 SCINPIIYPCSSQEFKKAF 337
Cdd:cd15172  263 CCLNPVLYAFIGVKFRNYF 281
7tmA_GPR35_55-like cd15923
G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of ...
28-210 2.73e-13

G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily is composed of GPR35, GPR55, and similar proteins. GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. GPR35 couples to G(13) and G(i/o) proteins, whereas GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Recently, lysophosphatidylinositol (LPI) has been identified as an endogenous ligand for GPR55, while several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast.


Pssm-ID: 320589 [Multi-domain]  Cd Length: 273  Bit Score: 69.79  E-value: 2.73e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  28 LLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTvLPFSaIFEILGYWAFGRVFCNIWAAVDV 107
Cdd:cd15923    2 LQYAIYIPTFVLGLLLNILALWVFCWRLKKWTETNIYMTNLAVADLLLLIS-LPFK-MHSYRRESAGLQKLCNFVLSLYY 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 108 LCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIgplFGWRQQAPEDETIC-----QINEEP 182
Cdd:cd15923   80 INMYVSIFTITAISVDRYVAIRYPLRARELRSPRKAAVVCAVIWVLVVTISI---PYFLLDSSNEKTMCfqrtkQTESLK 156
                        170       180
                 ....*....|....*....|....*...
gi 755547671 183 GYVLFSALGsFYVPLTIilVMYCRVYVV 210
Cdd:cd15923  157 VFLLLEIFG-FLLPLII--MTFCSARVI 181
7tmA_GPR63 cd15404
G protein-coupled receptor 63, member of the class A family of seven-transmembrane G ...
27-336 3.92e-13

G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR63, which is also called PSP24-beta or PSP24-2, and its closely related proteins found in vertebrates. GPR63 shares the highest sequence homology with GPR45 (Xenopus PSP24, mammalian PSP24-alpha or PSP24-1). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320526 [Multi-domain]  Cd Length: 265  Bit Score: 69.10  E-value: 3.92e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVD 106
Cdd:cd15404    1 VILSAVMIFILLVSFLGNFVVCLMVYQKAAMRSAINILLASLAFADMMLAVLNMPFALVTIITTRWIFGDAFCRVSAMFF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIgvsyplryptIVTQRRG------VRALLCV-WALSLVISIGPLFGWRQ-QAPEDETICQI 178
Cdd:cd15404   81 WLFVMEGVAILLIISIDRFL----------IIVQKQDklnpyrAKVLIAVsWAVSFCVAFPLAVGSPDlQIPSRAPQCVF 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 179 --NEEPG---YVLFSALGSFYVPLTIILVMYCRVyvvakresrglksgLKTDKSdseqvtlrihrknvpaegsgvssakn 253
Cdd:cd15404  151 gyTTNPGyqaYVILIMLIFFFIPFMVMLYSFMGI--------------LNTVRS-------------------------- 190
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 254 kthFSVRllkfsrekkAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPETVFKI---VFWLGYLNSCINPIIYPCSS 330
Cdd:cd15404  191 ---FKTR---------AFTTILILFIVFTVCWAPFTTYSLVATFNSHFYHKHNFFEIstwLLWLCYLKSALNPLIYYWRI 258

                 ....*.
gi 755547671 331 QEFKKA 336
Cdd:cd15404  259 KKFRDA 264
7tmA_P2Y2 cd15373
P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
27-335 4.29e-13

P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y2 belongs to the P2Y receptor family of purinergic G-protein coupled receptors and is implicated to play a role in the control of the cell cycle of endometrial carcinoma cells. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320495 [Multi-domain]  Cd Length: 283  Bit Score: 69.40  E-value: 4.29e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTvLPFSAIFEILG-YWAFGRVFCNIWAAV 105
Cdd:cd15373    1 ILLPVSYGIVFVVGLVLNILALYVFLFRTKPWNASTTYMFNLAISDTLYVLS-LPLLVYYYADEnDWPFSEALCKIVRFL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 106 DVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQAPEDETICQINEEP--- 182
Cdd:cd15373   80 FYTNLYCSILFLLCISVHRFLGVCYPVRSLRWLKVRYARIVSVVVWVIVLACQSPVLYFVTTSDKGGNITCHDTSSPelf 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 183 -GYVLFSALGS---FYVPLTIILVMYCrvyvvakresrglksglktdksdseqvtLRIHRKNVPAEGSGVSSAKnkthfs 258
Cdd:cd15373  160 dQFVVYSSVMLvllFCVPFVVILVCYA----------------------------LMVRKLLKPSAGTSTNSRS------ 205
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 259 vrllkfsrEKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFF-------PNFKPPETVFKIVFWLGYLNSCINPIIYPCSSQ 331
Cdd:cd15373  206 --------KKKSVKMIIIVLAVFILCFLPFHVTRTLYYSFrsmdlscGTLNAINLAYKVTRPLASANSCLDPILYFLAGQ 277

                 ....
gi 755547671 332 EFKK 335
Cdd:cd15373  278 SFRS 281
7tmA_GPR12 cd15961
G protein-coupled receptor 12, member of the class A family of seven-transmembrane G ...
44-337 6.74e-13

G protein-coupled receptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320627 [Multi-domain]  Cd Length: 268  Bit Score: 68.51  E-value: 6.74e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  44 NILVILSVACHRHLHSVTHYYIVNLAVADLLL-TSTVLPFsaifeILGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISI 122
Cdd:cd15961   18 NAIVVLIIFQNPSLRAPMFLLIGSLALADLLAgIGLILNF-----IFAYLLQSEAAKLVTVGLIVASFSASVCSLLAITV 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 123 DRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWrqQAPEDETICQINEEPGYVLFSALG-SFYVPLTIIL 201
Cdd:cd15961   93 DRYLSLYYALTYNSERTVTFTYVMLVLLWGASICLGLLPVMGW--NCLADESTCSVVRPLTKNNAAILSvSFLLMFALML 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 202 VMYCRVYVVAKRESrglksglktdksdsEQVTLRIHRKNVPaegsgvssaknkthfsvrllKFSREKKAAKTLGIVVGCF 281
Cdd:cd15961  171 QLYIQICKIVMRHA--------------HQIALQHHFLATS--------------------HYVTTRKGVSTLAIILGTF 216
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 755547671 282 VLCWLPFFLVMPIGSF-FPNFKPPETVFKIVFwlgylNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15961  217 AACWMPFTLYSLIADYtYPSIYTYATLLPATY-----NSIINPVIYAFRNQEIQKAL 268
7tmA_P2Y1-like cd15967
P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically ...
37-210 1.23e-12

P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320633 [Multi-domain]  Cd Length: 281  Bit Score: 68.18  E-value: 1.23e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  37 IIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTvLPFSAIFEILG-YWAFGRVFCNIWAAVDVLCCTASIM 115
Cdd:cd15967   11 FVVGLVGNVWGLKSLLANWKKLGNINVFVLNLGLADLLYLLT-LPFLVVYYLKGrKWIFGQVFCKITRFCFNLNLYGSIG 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 116 GLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFgwRQQAPEDETICQINEE----PGYVLFSA-- 189
Cdd:cd15967   90 FLTCISVYRYLAIVHPMRVMGRITTTHSVVISALVWLLVVIQSLPDLF--FSKTNSNGTKCFDTTFndylESYLTYSLgw 167
                        170       180
                 ....*....|....*....|..
gi 755547671 190 -LGSFYVPLTIILVMYCRVYVV 210
Cdd:cd15967  168 tVTGFVIPLLIILGCYGHVVVV 189
7tmA_GPR33 cd15120
orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled ...
27-337 1.36e-12

orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor GPR33, an orphan member of the chemokine-like receptor family, was originally identified as a pseudogene in humans as well as in several apes and rodent species. Although the intact GPR33 allele is still present in a small fraction of the human population, the human GPR33 contains a premature stop codon. The amino acid sequence of GPR33 shares a high degree of sequence identity with the members of the chemokine and chemoattractant receptors that control leukocyte chemotaxis. The human GPR33 is expressed in spleen, lung, heart, kidney, pancreas, thymus, gonads, and leukocytes.


Pssm-ID: 320248 [Multi-domain]  Cd Length: 282  Bit Score: 67.88  E-value: 1.36e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILvILSVACHRHLHSVTHYYIVNLAVADLLLTSTvLPFSAIFEILGY-WAFGRVFCNIWAAV 105
Cdd:cd15120    1 VLIAVALFVTFLVGLVVNGL-YLWVLGFKMRRTVNTLWFLHLILSNLIFTLI-LPFMAVHVLMDNhWAFGTVLCKVLNST 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 106 DVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIgPLFGWRQQAPED--ETICQIN---- 179
Cdd:cd15120   79 LSVGMFTSVFLLTAISLDRYLLTLHPVWSRQHRTNRWASAIVLGVWISAILLSI-PYLAFRETRLDEkgKTICQNNyals 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 180 ------------EEPGYVLFSA--LGSFYVPLTIILVMYCRvyvvakresrglksglktdksdseqVTLRIHRKNVpaeg 245
Cdd:cd15120  158 tnwesaevqasrQWIHVAMFVFrfLLGFLLPFLIITFCYVR-------------------------MALKMKERGL---- 208
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 246 sgvssaknkthfsvrllkfSREKKAAKTLGIVVGCFVLCWLPFFL--VMPIGSFFPNFkPPETVFKIVFWLGYLNSCINP 323
Cdd:cd15120  209 -------------------ARSSKPFKVMFTAVVSFFVCWLPYHLhsGLVLTRGRPPS-LTDITLLLTVGTTCFNTCFTP 268
                        330
                 ....*....|....
gi 755547671 324 IIYPCSSQEFKKAF 337
Cdd:cd15120  269 VLYLFVGENFKKVL 282
7tmA_SREB3_GPR173 cd15217
super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...
31-335 1.46e-12

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320345 [Multi-domain]  Cd Length: 329  Bit Score: 68.44  E-value: 1.46e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  31 VILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGY-WAFGRVFCNIWAAVDVL- 108
Cdd:cd15217    5 VLLGLIICVSLAGNLIVSLLVLKDRALHKAPYYFLLDLCLADTIRSAVCFPFVLVSIRNGSaWTYSVLSCKIVAFMAVLf 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 109 CCTASIMGLCiISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFG---WRQQAPEDETICQ-----INE 180
Cdd:cd15217   85 CFHAAFMLFC-ISVTRYMAIAHHRFYSKRMTFWTCIAVICMVWTLSVAMAFPPVFDvgtYKFIREEDQCIFEhryfkAND 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 181 EPGYVLFSA---LGSFYVPLTIILVMYCR-----VYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNVPAEGSGVssaK 252
Cdd:cd15217  164 TLGFMLMLAvliVATHIVYGKLLLFEYRHrkmkpVQMVPAISQNWTFHGPGATGQAAANWIAGFGRGPMPPTLLGI---R 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 253 NKTHFSVRLLKFSREKKAAKTLG----IVVGCFVLCWLPFFLVMPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIYPC 328
Cdd:cd15217  241 QNAHTANRRLLGMEEFKAEKRLGrmfyVITLSFLVLWSPYIVACYWRVFVKACSIPHRYLSTAVWMSFAQAGVNPIVCFL 320

                 ....*..
gi 755547671 329 SSQEFKK 335
Cdd:cd15217  321 LNKDLKK 327
7tmA_MWS_opsin cd15080
medium wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
36-334 1.56e-12

medium wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Medium Wave-Sensitive opsin, which mediates visual transduction in response to light at medium wavelengths (green). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 381742 [Multi-domain]  Cd Length: 280  Bit Score: 67.55  E-value: 1.56e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  36 LIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIM 115
Cdd:cd15080   10 LILLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTMYTSMHGYFVFGPTGCNLEGFFATLGGEIALW 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 116 GLCIISIDRYIGVSYPL---RYptivTQRRGVRALLCVWALSLVISIGPLFGWRQQAPED-ETIC---------QINEEp 182
Cdd:cd15080   90 SLVVLAIERYVVVCKPMsnfRF----GENHAIMGVAFTWVMALACAAPPLVGWSRYIPEGmQCSCgidyytlkpEVNNE- 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 183 GYVLFSALGSFYVPLTIILVMYCRVYVVAKRESRGLKSGLKTDKSdseqvtlrihrknvpaegsgvssaknkthfsvrll 262
Cdd:cd15080  165 SFVIYMFVVHFTIPLIVIFFCYGRLVCTVKEAAAQQQESATTQKA----------------------------------- 209
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755547671 263 kfsrEKKAAKTLGIVVGCFVLCWLP-----FFLVMPIGSffpNFKPpeTVFKIVFWLGYLNSCINPIIYPCSSQEFK 334
Cdd:cd15080  210 ----EKEVTRMVIIMVIAFLICWVPyasvaFYIFTHQGS---DFGP--IFMTIPAFFAKSSAVYNPVIYILMNKQFR 277
7tmA_CXCR5 cd15181
CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G ...
31-326 1.96e-12

CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR5 is a B-cell selective receptor that binds specifically to the homeostatic chemokine CXCL13 and regulates adaptive immunity. The receptor is found on all peripheral blood and tonsillar B cells and is involved in lymphocyte migration (homing) to specific tissues and development of normal lymphoid tissue. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341336 [Multi-domain]  Cd Length: 281  Bit Score: 67.47  E-value: 1.96e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  31 VILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTvLPFSAIFEILGyWAFGRVFCNIWAAVDVLCC 110
Cdd:cd15181    5 LAYSLVFLLGVVGNGLVLTILLRRRRSRRTTENYLLHLALADLLLLLT-FPFSVVESIAG-WVFGTFLCKLVGAIHKLNF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 111 TASIMGLCIISIDRYIGVSYPLRyptiVTQRRGVRA--LLC--VWALSLVISIGPLFGWRQQAPED--ETIC---QINEE 181
Cdd:cd15181   83 YCSSLLLACISVDRYLAIVHAIH----SYRHRRLRSvhLTCgsIWLVCFLLSLPNLVFLEVETSTNanRTSCsfhQYGIH 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 182 PGYVLFSA-----LGSFYVPLTIILVMYCRVYVVAKRESRGLKsglktdksdseqvtlrihrknvpaegsgvssaknkth 256
Cdd:cd15181  159 ESNWWLTSrflyhVVGFFLPLLIMGYCYATIVVTLCQSSRRLQ------------------------------------- 201
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755547671 257 fsvrllkfsrEKKAAKTLGIVVGCFVLCWLPFFLVMPI------GSFFPNFKPPETV---FKIVFWLGYLNSCINPIIY 326
Cdd:cd15181  202 ----------KQKAIRVAILVTLVFCLCWLPYNIVIFLdtlddlKAVVKNCKLNDLLdaaITVTESLGFSHCCLNPILY 270
7tmA_GPR17 cd15161
G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...
27-204 2.10e-12

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.


Pssm-ID: 320289 [Multi-domain]  Cd Length: 277  Bit Score: 67.43  E-value: 2.10e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTsTVLPFSAIFEILG-YWAFGRVFCNIWAAV 105
Cdd:cd15161    1 ILFALFYILVFILAFPGNTLALWLFIHDRKSGTPSNVFLMHLAVADLSYV-LILPMRLVYHLSGnHWPFGEVPCRLAGFL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 106 DVLCCTASIMGLCIISIDRYIGVSYPLRYPTIvtqRRGVRA-LLC--VWALsLVISIGPLFGWRQQAP-EDETICQ---I 178
Cdd:cd15161   80 FYLNMYASLYFLACISVDRFLAIVHPVKSMKI---RKPLYAhVVCgfLWVI-VTVAMAPLLVSPQTVEvNNTTVCLqlyR 155
                        170       180
                 ....*....|....*....|....*.
gi 755547671 179 NEEPGYVLFSALGSFYVPLTIILVMY 204
Cdd:cd15161  156 EKASRGALVSLAVAFTIPFVTTVTCY 181
7tmA_S1PR4_Edg6 cd15349
sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial ...
28-336 3.01e-12

sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial differentiation gene 6 (Edg6), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320471 [Multi-domain]  Cd Length: 271  Bit Score: 66.73  E-value: 3.01e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  28 LLGVILGGLIIfgvLGNILVILSVACHRHLHSVTHYYIVNLAVADLL-----LTSTVLPFSAIFEILGYWAFGRvfcniw 102
Cdd:cd15349    5 VLFICISVLII---LENLLVLLAILRRVRLRRWVYICLANIALSDLLtgtsyLVNICLSGERTFRLTPALWFLR------ 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 103 AAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWrqqapedETICQINE-- 180
Cdd:cd15349   76 EGLLFTALAASTFSLLVTAVERYATMVRPVAENTATKTYRVYGMIVLCWILAFLIGFLPLLGW-------NCLCDFRScs 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 181 ------EPGYVLFSALGSFYVPLTIIlVMYCRVYVVAKresrglksglktdkSDSEQVTLRIHRKNvpaegsgvssaknk 254
Cdd:cd15349  149 sllplySKSYILFCLVIFFIILLTII-GLYFAIYCLVR--------------ASGQRVISARSRRR-------------- 199
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 255 thfSVRLLKfsrekkaakTLGIVVGCFVLCWLPFFLVMpIGSFFPNFKPPETVFKI--VFWLGYLNSCINPIIYPCSSQE 332
Cdd:cd15349  200 ---SLRLLK---------TVLMILGAFMVCWGPLFILL-LVDFFCSSRSCKPLFGMewVLALAVLNSAINPLIYSFRSLE 266

                 ....
gi 755547671 333 FKKA 336
Cdd:cd15349  267 VRRA 270
7tmA_NTSR2 cd15356
neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G ...
40-337 3.85e-12

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320478 [Multi-domain]  Cd Length: 285  Bit Score: 66.43  E-value: 3.85e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  40 GVLGNIL---VILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAI-FEILGY-WAFGRVFCNIWAAVDVLCCTASI 114
Cdd:cd15356   14 GAAGNALtihLVLKKRSLRGLQGTVHYHLVSLALSDLLILLISVPIELYnFVWFHYpWVFGDLVCRGYYFVRDICSYATV 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 115 MGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIgPLFGWRQQAPEDETiCQINEEPG----------- 183
Cdd:cd15356   94 LNIASLSAERYLAICQPLRAKRLLSKRRTKWLLALIWASSLGFAL-PMAFIMGQKYELET-ADGEPEPSsrvctvlvsra 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 184 ----YVLFSALGSFYVPLTIILVMYCrvyvvakresrglksglktdksdseqVTLrihrknvpaegsgvssaknkTHFSV 259
Cdd:cd15356  172 tlkvFIQVNAFVSFVLPLALIAFLNG--------------------------VTV--------------------SHLRI 205
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 260 RLLKFSrekkaAKTLGIVVGCFVLCWLPFFLVMPIGSFFPN--FKPPETVFKIVFW-----LGYLNSCINPIIYPCSSQE 332
Cdd:cd15356  206 QSLQHS-----VQVLRAIVIAYVICWLPYHARRLMFCYVPDdaWTDSLYNFYHYFYmltntLFYVSSAVNPLLYNVVSSS 280

                 ....*
gi 755547671 333 FKKAF 337
Cdd:cd15356  281 FRKLF 285
7tmA_SUCNR1_GPR91 cd15378
succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
38-226 4.93e-12

succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Succinate receptor (SUCNR1) GPR91 exclusively couples to G(i) protein to inhibit cAMP production and also activates PLC-beta to increase intracellular calcium concentrations in an inositol phosphate dependent mechanism. Succinate, an intermediate molecule of the citric cycle, is shown to cause cardiac hypertrophy via GPR91 activation. Furthermore, succinate-induced GPR91 activation is involved in the regulation of renin-angiotensin system and is suggested to play an important role in the development of renovascular hypertension and diabetic nephropathy. SUCNR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC).


Pssm-ID: 320500 [Multi-domain]  Cd Length: 283  Bit Score: 66.28  E-value: 4.93e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  38 IFGVLGNILVILS-VACHRHLHSvTHYYIVNLAVADLLLTSTvLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMG 116
Cdd:cd15378   12 VLGFIGNTIVILGyIFCLKNWKS-SNIYLFNLSVSDLAFLCT-LPMLVYSYSNGQWLFGDFLCKSNRYLLHANLYSSILF 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 117 LCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALsLVISIGPLFGWRQQAPEDE-TICQINEEPG-------YVLFS 188
Cdd:cd15378   90 LTFISIDRYLLIKYPFREHILQKKRSAVAISLAIWVL-VTLELLPILTFIGPNLKDNvTKCKDYASSGdatnsliYSLFL 168
                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 755547671 189 ALGSFYVPLTIILVMYCRVYVVAKRESRGLKSGLKTDK 226
Cdd:cd15378  169 TVTGFLIPLCVMCFFYYKIALFLKNRNRQLANATSFEK 206
7tmA_CysLTR2 cd15157
cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G ...
36-334 5.20e-12

cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320285 [Multi-domain]  Cd Length: 278  Bit Score: 66.27  E-value: 5.20e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  36 LIIF--GVLGNILVI-LSVACHRHLHSVtHYYIVNLAVADLLLTSTvLPFSAIFEILG-YWAFGRVFCNIWAAVDVLCCT 111
Cdd:cd15157    8 LIIFvlGVVGNGLSIyVFLQPSKKKTSV-NIFMLNLAVSDLMFVST-LPFRADYYLMGsHWVFGDIACRIMSYSLYVNMY 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 112 ASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISiGPLFGWRQQAPEDETICQINEEPGYVLFSALG 191
Cdd:cd15157   86 CSIYFLTVLSIVRFLAIVHPFKLWKVTSIKYARILCAVIWIFVMAAS-SPLLSKGTSKYNSQTKCLDLHPSKIDKLLILN 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 192 S------FYVPLTIILVMYCRVyvvakresrgLKSGLKTdksdseqvtlrihrkNVPAEGSGVSsaknkthfsvrllkfs 265
Cdd:cd15157  165 YivlvvgFILPFCTLSICYILI----------IKALLKP---------------RVPQSKLRVS---------------- 203
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755547671 266 rEKKAAKTLGIVVGCFVLCWLPFFLVMPIgsFFPNFKPPETVFK------IVFWLGYLNSCINPIIYPCSSQEFK 334
Cdd:cd15157  204 -HKKALLTIIITLILFLLCFLPYHILRTV--HLMQWSEGQCNLRlhkavvITLCLAAANSCLDPLLYYFAGENFK 275
7tmA_GPR34-like cd15148
putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G ...
38-156 5.75e-12

putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 34 of unknown function. Orphan GPR34 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320276 [Multi-domain]  Cd Length: 282  Bit Score: 65.87  E-value: 5.75e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  38 IFGVLGNILVILSVAC-HRHLHSVtHYYIVNLAVADLLLTsTVLPFSAIFEILG-YWAFGRVFCNIWAAVDVLCCTASIM 115
Cdd:cd15148   12 LFGLVGNLLALWVFLFiHRKRNSV-RIFLINVAIADLLLI-ICLPFRILYHVNNnQWTLGPLLCKVVGNLFYMNMYISII 89
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 755547671 116 GLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLV 156
Cdd:cd15148   90 LLGFISLDRYLKINRSSRRQKFLTRKWSIVACGVLWAVALV 130
7tmA_SREB2_GPR85 cd15218
super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of ...
33-337 6.61e-12

super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320346 [Multi-domain]  Cd Length: 330  Bit Score: 66.59  E-value: 6.61e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  33 LGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFsaIFEIL---GYWAFGRVFCNIWAAVDVLC 109
Cdd:cd15218    7 LGFIIGVSVVGNLLISILLVKDKTLHRAPYYFLLDLCCSDILRSAICFPF--VFTSVkngSTWTYGTLTCKVIAFLGVLS 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 110 CTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFG---WRQQAPEDETICQ-----INEE 181
Cdd:cd15218   85 CFHTAFMLFCISVTRYLAIAHHRFYTKRLTFWTCLAVICMVWTLSVAMAFPPVLDvgtYSFIREEDQCTFQhrsfrANDS 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 182 PGYVLFSA---LGSFYVPLTIILVMYCR-----VYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNVPAEGSGVSSAKN 253
Cdd:cd15218  165 LGFMLLLAlilLATQLVYLKLIFFVHDRrkmkpVQFVAAVSQNWTFHGPGASGQAAANWLAGFGRGPTPPTLLGIRQNAN 244
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 254 KTHfSVRLL---KFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIYPCSS 330
Cdd:cd15218  245 TTG-RRRLLvldEFKMEKRISRMFYIMTFLFLTLWGPYLVACYWRVFARGPVVPGGFLTAAVWMSFAQAGINPFVCIFSN 323

                 ....*..
gi 755547671 331 QEFKKAF 337
Cdd:cd15218  324 RELRRCF 330
7tmA_PD2R2_CRTH2 cd15118
prostaglandin D2 receptor, member of the class A family of seven-transmembrane G ...
31-333 6.61e-12

prostaglandin D2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. PD2R2 is involved in mediating chemotaxis of Th2 cells, eosinophils, and basophils generated during allergic inflammatory processes. CRTH2 (PD2R2), but not DP receptor, undergoes agonist-induced internalization which is one of key processes that regulates the signaling of the GPCR.


Pssm-ID: 320246 [Multi-domain]  Cd Length: 284  Bit Score: 65.98  E-value: 6.61e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  31 VILGGLI-IFGVLGNILVILSVACHRHlHSVTHYYIVNLAVADLLLTSTvLPFSAIFEILGY-WAFGRVFCNIWAAVDVL 108
Cdd:cd15118    4 ICLHGIVsTLGIVENLLILWVVGFRLR-RTVISIWILNLALSDLLATLS-LPFFTYYLASGHtWELGTTFCRIHSSIFFL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 109 CCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIgPLFGWRQQAPEDE--------------- 173
Cdd:cd15118   82 NMFVSGFLLAAISLDRCLLVVKPVWAQNHRNVAAAKKICGVIWAMALINTI-PYFVFRDVIERKDgrklcyynfalfsps 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 174 -----TICQINEEpGYVLFSALGSFYVPLTIILVMYCrvyvvakresrglksglktdksdseQVTLRI-HRKNvpaegsg 247
Cdd:cd15118  161 pdnnhPICKQRQE-GLAISKLLLAFLIPLVIIAVSYA-------------------------VVSLIIrHRCR------- 207
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 248 vssaknkthfsvrllkfSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPN----FKPPETVFKIVFWLGYLNSCINP 323
Cdd:cd15118  208 -----------------RRPGRFVRLVVSVVVSFALCWAPYHIFSIIEVMAHNqhslRPLVIQGLPFATTLAFLNSVLNP 270
                        330
                 ....*....|
gi 755547671 324 IIYPCSSQEF 333
Cdd:cd15118  271 VLYVFSCPDF 280
7tmA_GPR26_GPR78-like cd15219
G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G ...
28-214 6.80e-12

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan G-protein coupled receptor 26 (GPR26) and GPR78 are constitutively active and coupled to increased cAMP formation. They are closely related based on sequence homology and comprise a conserved subgroup within the class A G-protein coupled receptor (GPCR) superfamily. Both receptors are widely expressed in selected tissues of the brain but their endogenous ligands are unknown. GPR26 knockout mice showed increased levels of anxiety- and depression-like behaviors, whereas GPR78 has been implicated in susceptibility to bipolar affective disorder and schizophrenia. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320347 [Multi-domain]  Cd Length: 264  Bit Score: 65.56  E-value: 6.80e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  28 LLGVILGGLIIFGVLGNILVILSVACHRHLHS-VTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVD 106
Cdd:cd15219    1 LLAVLLVVVLVVSLLSNLLVLLCFLYSAELRKqVPGIFLLNLSFCNLLLTVLNMPFTLLGVVRNRQPFGDGFCQAVGFLE 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPL-FGW--RQQAPEDETICQINEEPG 183
Cdd:cd15219   81 TFLTSNAMLSMAALSIDRWIAVVFPLSYTSKMRYRDAALMVGYSWLHSLTFSLVALfLSWlgYSSLYASCTLHLPREEER 160
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 755547671 184 -----YVLFSALGSFYVPLTIILVMYCRVYVVAKRE 214
Cdd:cd15219  161 rrfavFTAFFHAFTFLLSLLVLCVTYLKVLKVRRRQ 196
7tmA_NTSR cd15130
neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
27-337 7.04e-12

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320258 [Multi-domain]  Cd Length: 281  Bit Score: 65.74  E-value: 7.04e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVT---HYYIVNLAVADLLLTSTVLPFSAIFEILGY--WAFGRVFCNI 101
Cdd:cd15130    1 VLVTAIYLALFVVGTVGNSVTLFTLARKKSLQSLQstvRYHLGSLALSDLLILLLAMPVELYNFIWVHhpWAFGDAGCRG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 102 WAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQAPEDEticqiNEE 181
Cdd:cd15130   81 YYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAIPMLFTMGLQNESDD-----GTH 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 182 PG---------------YVLFSALGSFYVPLTIILVMYCrvyVVAKRESRGLKSGLKTDKSdseqvtlrihrknvpaegs 246
Cdd:cd15130  156 PGglvctpivdtatlkvVIQVNTFMSFLFPMLVTSILNT---VIANKLVQALRRGVLVLRA------------------- 213
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 247 gvssaknkthfsvrllkfsrekkaaktlgiVVGCFVLCWLPFFLVMPIGSFFPNFKPPETVFKIVFW-------LGYLNS 319
Cdd:cd15130  214 ------------------------------VVIAFVVCWLPYHVRRLMFCYISDEQWTTFLFDFYHYfymltnaLFYVSS 263
                        330
                 ....*....|....*...
gi 755547671 320 CINPIIYPCSSQEFKKAF 337
Cdd:cd15130  264 AINPILYNLVSANFRQVF 281
7tmA_CysLTR cd15921
cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G ...
36-337 1.02e-11

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320587 [Multi-domain]  Cd Length: 283  Bit Score: 65.21  E-value: 1.02e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  36 LIIF--GVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTvLPFSAIFEIL-GYWAFGRVFCNIWAAVDVLCCTA 112
Cdd:cd15921    8 ILIFilGLTGNSISVYVFLSQYRSQTPVSVLMVNLAISDLLLVCT-LPLRLTYYVLnSHWPFGDIACRIILYVLYVNMYS 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 113 SIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQAPEDETIC-QINEEP-GYVLF--- 187
Cdd:cd15921   87 SIYFLTALSVFRYLALVWPYLYLRVQTHSVAGIICGLIWILMGLASSPLLFAKSKQHDEGSTRClELAHDAvDKLLLiny 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 188 -SALGSFYVPLTIILVMYCRVyvvakresrglksglktdksdseqvtLRIHRKNVPAEGSGVSSaknkthfsvrllkfsr 266
Cdd:cd15921  167 vTLPVGFVVPFMTVIFCYIFI--------------------------IKNLLKPSPALGRTRPS---------------- 204
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755547671 267 EKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPETVFK--------IVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15921  205 RRKACALIIISLGIFLVCFLPYHIVRTIHLITERQIKESCGYIlrvrkaavITLCLAASNSCFDPLLYFFVGENFRSRL 283
7tmA_RNL3R1 cd15926
relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G ...
27-337 1.51e-11

relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R1 is also known as GPCR135, relaxin family peptide receptor 3 (RXFP3), and somatostatin- and angiotensin-like peptide receptor (SALPR). RNL3/relaxin-3, a member of the insulin superfamily, is an endogenous neuropeptide ligand for RNL3R1. RNL3R1 is predominantly expressed in brain regions and implicated in stress, anxiety, and feeding, and metabolism. RNL3R1 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation, and also activates Erk1/2 signaling pathway.


Pssm-ID: 320592 [Multi-domain]  Cd Length: 288  Bit Score: 64.92  E-value: 1.51e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVI-LSVACHRHLHSVTHYYIVNLAVADLLLTSTvLPFSAIFEILGY-WAFGRVFCNIWAA 104
Cdd:cd15926    1 IIISIVYSVVCALGLVGNLLVLyLMKSKQGWKKSSINLFVTSLAVTDFQFVLT-LPFWAVENALDFtWLFGKAMCKIVSY 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 105 VDVLCCTASIMGLCIISIDRYIGVSYPLRyptivTQRRGVR---ALLCV--WALSLVISIGPLFGWRQQAPEDETICQIN 179
Cdd:cd15926   80 VTAMNMYASVFFLTAMSVARYHSVASALK-----SKRRRGCcsaKWLCVliWVLAILASLPNAIFSTTATVSNEELCLVK 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 180 EEPG----------YVLFSALGSFYVPLTIILVMYCrvyvvakresrglksglktdksdseqVTLR-IHRKNVPAegsgv 248
Cdd:cd15926  155 FPDNrgnaqfwlglYHAQKVLLGFLIPLGIISLCYL--------------------------LLVRfITDKNITG----- 203
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 249 SSAKnkthfsvrllkfsREKKAAKTLGIVVGCFVLCWLP--------FFLVMPIGSF-FPNFKPPETVFKIVFWLGYLNS 319
Cdd:cd15926  204 SSTK-------------RRSKVTKSVTIVVLSFFLCWLPnqalttwgILIKLNVVHFsYEYFTTQVYIFPITVCLAHSNS 270
                        330
                 ....*....|....*...
gi 755547671 320 CINPIIYPCSSQEFKKAF 337
Cdd:cd15926  271 CLNPILYCLMRREFRKAL 288
7tmA_GPR3_GPR6_GPR12-like cd15100
G protein-coupled receptors 3, 6, 12, and related proteins, member of the class A family of ...
44-336 1.64e-11

G protein-coupled receptors 3, 6, 12, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3. Also included in this subfamily is GPRx, also known as GPR185, which involved in the maintenance of meiotic arrest in frog oocytes.


Pssm-ID: 320228 [Multi-domain]  Cd Length: 268  Bit Score: 64.42  E-value: 1.64e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  44 NILVILSVACHRHLHSVTHYYIVNLAVADLLL-TSTVLPFSAIFEIlgywaFGRVFCNIWAAVDVLCCTASIMGLCIISI 122
Cdd:cd15100   18 NAIVVAIIFSTPSLRAPMFLLIGSLALADLLAgLGLILHFVFRYCV-----YSEALSLVSVGLLVAAFSASVCSLLAITV 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 123 DRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWrqQAPEDETICQINEEPGYVLFSAL-GSFYVPLTIIL 201
Cdd:cd15100   93 DRYLSLYNALTYYSERTLTFTYVMLALLWTLALGLGLLPVLGW--NCLREGSSCSVVRPLTKNHLAVLaVAFLLVFALML 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 202 VMYCRVYVVAKREsrglksglktdksdSEQVTLRIHRKNVPAegsgvssaknkthfsvrllkFSREKKAAKTLGIVVGCF 281
Cdd:cd15100  171 QLYAQICRIVLRH--------------AHQIALQRHFLAPSH--------------------YVATRKGVSTLALILGTF 216
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 755547671 282 VLCWLPFFLVMPIGSffpNFKPPETVFKIVFWLGYlNSCINPIIYPCSSQEFKKA 336
Cdd:cd15100  217 AACWIPFAVYCLLGD---GSSPALYTYATLLPATY-NSMINPIIYAFRNQDIQKV 267
7tmA_CX3CR1 cd15186
CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G ...
27-335 1.65e-11

CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CX3CR1 is an inflammatory receptor specific for CX3CL1 (also known as fractalkine in human), which is involved in the adhesion and migration of leukocytes. The CX3C chemokine subfamily is only represented by CX3CL1, which exists in both soluble and membrane-anchored forms. Membrane-anchored form promotes strong adhesion of receptor-bearing leukocytes to CX3CL1-expressing endothelial cells. On the other hand, soluble CX3CL1, which is released by the proteolytic cleavage of membrane-anchored CX3CL1, is a potent chemoattractant for CX3CR1-expressing T cells and monocytes. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 320314 [Multi-domain]  Cd Length: 273  Bit Score: 64.47  E-value: 1.65e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTvLPFSAIFEILGyWAFGRVFCNIWAAVD 106
Cdd:cd15186    1 IFLSIFYSLVFAFGLVGNLLVVLALTNSGKSKSITDIYLLNLALSDLLFVAT-LPFWTHYLINE-WGLHNAMCKLTTAFF 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIGV---SYPLRYPTIvtqRRGVRALLCVWALSLVISIgPLFGWRQQAPED------ETICQ 177
Cdd:cd15186   79 FIGFFGGIFFITVISIDRYLAIvlaANSMNNRTV---QHGVTISLGVWAAAILVAV-PQFMFTKMKENEclgdypEVLQE 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 178 INEEPGYVLFSALGsFYVPLTIILVMYCRVYvvakresrglksglktdksdseqvtlrihrknvpaegsgvssaknKTHF 257
Cdd:cd15186  155 IWPVLRNVELNFLG-FLLPLLIMSYCYFRII---------------------------------------------QTLF 188
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 258 SVrllKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSF-FPNFKPPETVFKIVFW-------LGYLNSCINPIIYPCS 329
Cdd:cd15186  189 SC---KNHKKARAIKLILLVVIVFFLFWTPYNVMIFLETLkLYDFFPSCDMKKDLRLalsvtetIAFSHCCLNPLIYAFA 265

                 ....*.
gi 755547671 330 SQEFKK 335
Cdd:cd15186  266 GEKFRR 271
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
36-337 2.02e-11

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 64.51  E-value: 2.02e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  36 LIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIM 115
Cdd:cd15978   10 IFLLSVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFTLIPNLLKDFIFGSAVCKTATYFMGISVSVSTF 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 116 GLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISI-----GPLFGWRQQAPEDETICQ------INEEPGY 184
Cdd:cd15978   90 NLVAISLERYSAICKPLKSRVWQTKSHALKVIAATWCLSFTIMLpypiySNLVPFTRINNSTGNMCRllwpndVTQQSWY 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 185 VlFSALGSFYVPLTIILVMYcrvyvvakresrGLksglktdksdseqVTLRIHRKnvpaegsgvssaknkthfsvrlLKF 264
Cdd:cd15978  170 I-FLLLILFLIPGIVMMTAY------------GL-------------ISLELYRG----------------------IKF 201
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755547671 265 SREKK-AAKTLGIVVGCFVLCWLPFFLVMPIGSF---FPNFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15978  202 LMAKKrVIRMLIVIVILFFLCWTPIFSANAWRAFdtrSADRLLSGAPISFIHLLSYTSACVNPIIYCFMNKRFRMGF 278
7tmA_GPR35-like cd15164
G protein-coupled receptor 35 and similar proteins, member of the class A family of ...
31-337 2.14e-11

G protein-coupled receptor 35 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. Several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast. GPR35 couples to G(13) and G(i/o) proteins.


Pssm-ID: 320292 [Multi-domain]  Cd Length: 272  Bit Score: 64.20  E-value: 2.14e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  31 VILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTvLPFSAIFEILGYWafGRVFCNIWAAVDVLCC 110
Cdd:cd15164    5 IIYIPILFFGLLFNVLALWVFCCKMKKWTETRVYMINLAVADCCLLFS-LPFVLYFLKHSWP--DDELCLVLQSIYFINR 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 111 TASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALsLVISIGPLFGWRQQapeDETIC--QINEEPGY--VL 186
Cdd:cd15164   82 YMSIYIITAIAVDRYIAIKYPLKAKSLRSPRKAALTCGLLWVL-VIISVSLRLAWEEQ---EENFCfgKTSTRPSKrtLI 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 187 FSALGsFYVPLtIILVmYCRVYVVakresRGLKSGLKTDKSDSEQVtlrihrknvpaegsgvssaknkthfsvrllkfsr 266
Cdd:cd15164  158 FSLLG-FFIPL-IILS-FCSIQVI-----RSLKKKKKTNPHEEKLI---------------------------------- 195
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755547671 267 eKKAAKTLGIVVGCFVLCWLPF-------FLVMPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15164  196 -QKAIYIVSANLIVFIVCFLPLhigllvrFVMESNKASCSLIQNIRNFIYVASCLANANCCLDAICYYFVAKEFQEAS 272
7tmA_P2Y8 cd15368
purinergic receptor P2Y8, member of the class A family of seven-transmembrane G ...
27-337 2.14e-11

purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320490 [Multi-domain]  Cd Length: 281  Bit Score: 64.40  E-value: 2.14e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTStVLPFSAIFEILGY-WAFGRVFCNIWAAV 105
Cdd:cd15368    1 VILPVVYSLVALISIPGNLFSLWLLCFHTKPKTPSIIFMINLSLTDLMLAC-FLPFQIVYHIQRNhWIFGKPLCNVVTVL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 106 DVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVIsIGPL----FGWRQQAPEDETICQINEE 181
Cdd:cd15368   80 FYANMYSSILTMTCISIERYLGVVYPMRSMRWRKKRYAVAACIGMWLLVLTA-LSPLertdLTYYVKELNITTCFDVLKW 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 182 PGYVLFSALGSFYVPLTIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQvtlrihrknvpaegsgvssaknkthfsvrl 261
Cdd:cd15368  159 TMLPNIAAWAAFLFTLFILLFLIPFIITVYCYVLIILKLVQTSERYGREQ------------------------------ 208
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755547671 262 lkfsrEKKAAKTLGIVVGCFVLCWLP---FFLVMPIGSFFPNfKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15368  209 -----KRRAIYLALIVLLVFITCFAPnnfILLAHMVSRLFYG-KSLYHAYKLTLSLSCLNSCLDPFIYYFASKEFRKKL 281
7tmA_OXGR1 cd15375
2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G ...
29-337 2.16e-11

2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; 2-oxoglutarate receptor 1 (OXGR1) is also known as GPR80, GPR99, or P2Y15. OXGR1 functions as a receptor for alpha-ketoglutarate, a citric acid cycle intermediate, and acts exclusively through a G(q)-dependent pathway. OXGR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC). OXGR1 has also been reported as a potential third cysteinyl leukotriene receptor with specificity for leukotriene E4.


Pssm-ID: 320497 [Multi-domain]  Cd Length: 280  Bit Score: 64.33  E-value: 2.16e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  29 LGVILGGLIIFGVLGNILVILS-VACHRHLHSVThYYIVNLAVADLLLTSTvLPFSAIFEILG-YWAFGRVFCNIWAAVD 106
Cdd:cd15375    3 LPVMYSIIFIVGFPGNIIAIFVyLFKMRPWKSST-IIMLNLALTDLLYVTS-LPFLIYYYINGeSWIFGEFMCKFIRFIF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSL--VISIGPLFGWRQQapEDETIC---QINEE 181
Cdd:cd15375   81 HFNLYGSILFLTCFSIFRYVVIVHPLRAFQVQKRRWAIVACAVVWVISLaeVSPMTFLITTKEK--NNRTICldfTSSDN 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 182 PG----YVLFSALGSFYVPLTIILVMYCRVYvvakresRGLKSGLKTDksdseqvtlrihrknvpaegsgvssaknkthf 257
Cdd:cd15375  159 LNtiwwYNWILTVLGFLLPLVIVTLCYTRII-------YTLAKGPHTG-------------------------------- 199
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 258 svrllkfSREKKAAKTLGIVV-GCFVLCWLPF--FLVMPIGSFFPNFKPP-----ETVFKIVFWLGYLNSCINPIIYPCS 329
Cdd:cd15375  200 -------SASKQKARRLIILIlLVFYVCFLPFhiLRVVRIETRLPPVSCClkhqvHAIYIITRPLAALNTFGNLLLYVVS 272

                 ....*...
gi 755547671 330 SQEFKKAF 337
Cdd:cd15375  273 GDNFQQAF 280
7tmA_P2Y3-like cd16001
P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G ...
27-334 2.22e-11

P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y3-like proteins are an uncharacterized group that belongs to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320667 [Multi-domain]  Cd Length: 284  Bit Score: 64.40  E-value: 2.22e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTstvlpFSAIFEILGY-----WAFGRVFCNi 101
Cdd:cd16001    1 ILLPVTYSVVFVLGLPLNGTVLWLSWCRTKRWTCSTIYLVNLAVADLLYV-----CSLPLLIVNYamrdrWPFGDFLCK- 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 102 waAVDVLCCT---ASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQAPEDETICQI 178
Cdd:cd16001   75 --LVRFLFYTnlyGSILFLTCISVHRFLGVCYPIRSLAYRTRRLAVIGSAATWILVVLQLLPTLVYARTGSINNRTVCYD 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 179 NEEP---------GYVLfsALGSFYVPLTIILVMYCrvyvvakresrglksglktdksdseqvtLRIHRKNVPAEGSGVS 249
Cdd:cd16001  153 LTSPdnfgnyfpyGMVL--TVTGFLIPFLIILLCYC----------------------------LMIKSLIRSEEAAGVG 202
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 250 SAknkthfsVRllkfsreKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFF--------PNFKPPETVFKIVFWLGYLNSCI 321
Cdd:cd16001  203 KA-------AR-------AKSIRTILLVCGLFALCFVPFHITRTIYLFVrvylvqdcPLLQFVSLAYKIWRPLVSFNSCI 268
                        330
                 ....*....|...
gi 755547671 322 NPIIYPCSSQEFK 334
Cdd:cd16001  269 NPLLYFLSGDSNR 281
7tmA_S1PR3_Edg3 cd15345
sphingosine-1-phosphate receptor subtype 3 (S1PR3 or S1P3), also called endothelial ...
39-337 2.95e-11

sphingosine-1-phosphate receptor subtype 3 (S1PR3 or S1P3), also called endothelial differentiation gene 3 (Edg3), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320467 [Multi-domain]  Cd Length: 270  Bit Score: 63.68  E-value: 2.95e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  39 FGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLL-----LTSTVLPFSAIFEI-LGYWAF--GRVFCNIwaavdvlcc 110
Cdd:cd15345   13 FIVLENLMVLIAIWKNNRFHNRMYFFIGNLALCDLLagiayKVNILMSGKKTFSLsPTQWFLreGSMFVAL--------- 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 111 TASIMGLCIISIDRYIGVsYPLRyPTIVTQRRGVRALL-CVWALSLVISIGPLFGWR--QQAPEDETICQINEEPgYVLF 187
Cdd:cd15345   84 GASTFSLLAIAIERHLTM-IKMR-PYDANKRYRVFLLIgTCWLISVLLGALPILGWNclDNLPDCSTILPLYSKK-YVAF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 188 sALGSFYVPLTIILVMYCRVYVVAKRESRGLksglkTDKSDSEQvtlrihrknvpaegsgvssaknkthfSVRLLkfsre 267
Cdd:cd15345  161 -CISIFIAILVAIVILYARIYILVKSSSRRV-----TNHRNSER--------------------------SMALL----- 203
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755547671 268 kkaaKTLGIVVGCFVLCWLPFFLVMPIgSFFPNFKPPETVFKIVFW--LGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15345  204 ----RTVVIVVGVFIACWSPLFILLLI-DVACEVKQCPILYKADWFiaLAVLNSAMNPIIYTLASKEMRRAF 270
7tmA_LPAR5 cd15154
lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G ...
36-159 3.26e-11

lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 5 (LPAR5) is a G protein-coupled receptor that binds the bioactive lipid lysophosphatidic acid (LPA) and is involved in maintenance of human hair growth. Phylogenetic analysis of the class A GPCRs shows that LAPR5 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(q) and G(12/13) proteins.


Pssm-ID: 320282 [Multi-domain]  Cd Length: 285  Bit Score: 63.63  E-value: 3.26e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  36 LIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTvLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIM 115
Cdd:cd15154   10 LFPVGLLLNAVALWVFVRYLRLHSVVSIYMCNLALSDLLFTLS-LPLRIYYYANHYWPFGNFLCQFSGSIFQMNMYGSCL 88
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 755547671 116 GLCIISIDRYIGVSYPLRYPTIvtQRRGVRALLC--VWALSLVISI 159
Cdd:cd15154   89 FLMCINVDRYLAIVHPLRFRHL--RRPKVARLLClaVWALILGGSV 132
7tmA_GPR4 cd15366
proton-sensing G protein-coupled receptor 4, member of the class A family of ...
64-238 3.30e-11

proton-sensing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein-coupled receptor 4 (GPR4) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. GPR4 overexpression in melanoma cells was shown to reduce cell migration, membrane ruffling, and cell spreading under acidic pH conditions. Activation of GPR4 via extracellular acidosis is coupled to the G(s), G(q), and G(12/13) pathways.


Pssm-ID: 320488 [Multi-domain]  Cd Length: 280  Bit Score: 63.66  E-value: 3.30e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  64 YIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRG 143
Cdd:cd15366   38 YLLNLSVSDLLYIATLPLWIDYFLHRDNWIHGPESCKLFGFIFYTNIYISIAFLCCISVDRYLAVAHPLRFAKVRRVKTA 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 144 VRALLCVWALSLVISIGPLFGWR------------QQAPEDETICQINeepgyvLFSALGSFYVPLTIILVMYcrvyvva 211
Cdd:cd15366  118 VAVSAVVWAIEIGANSAPLFHDElfrdrynhtfcfEKYPMEDWVAWMN------LYRVFVGFLFPWVLMLFSY------- 184
                        170       180
                 ....*....|....*....|....*..
gi 755547671 212 kresRGLKSGLKTDKSDSEQVTLRIHR 238
Cdd:cd15366  185 ----RGILRAVRGNVSTEQQEKAKIKR 207
7tmA_LPAR3_Edg7 cd15343
lysophosphatidic acid receptor subtype 3 (LPAR3 or LPA3), also called endothelial ...
38-332 3.52e-11

lysophosphatidic acid receptor subtype 3 (LPAR3 or LPA3), also called endothelial differentiation gene 7 (Edg7), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320465 [Multi-domain]  Cd Length: 274  Bit Score: 63.74  E-value: 3.52e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  38 IFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLlltstvlpFSAIFEILGYWAFGRV----FCNIWAAVDVL---CC 110
Cdd:cd15343   12 LFIFVSNSLVIAAVVKNKRFHYPFYYLLANLAAADF--------FAGIAYVFLMFNTGPVsktlTVNRWFLRQGLldtSL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 111 TASIMGLCIISIDRYIGVsYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWrqqapedETICQINE--------EP 182
Cdd:cd15343   84 SASLTNLLVIAVERHISI-MRMKVHSNLTKRRVTLLIALVWAIAIFMGAVPTLGW-------NCICNISAcsslapiySR 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 183 GYVLFSALGSFYVPLtIILVMYCRVYVVAKRESRGLKSglktdksdseQVTLRIHRKNVPAegsgvssaknkthfsvrll 262
Cdd:cd15343  156 SYLVFWSVSNLVVFL-IMVVVYLRIYVYVQRKTNVLSP----------HTSGSINRRRTPI------------------- 205
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 263 kfsrekKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIYPCSSQE 332
Cdd:cd15343  206 ------KLMKTVMTVLGAFVICWTPGLVVLLLDGLNCTRCGVQHVKRWFLLLALLNSVMNPIIYSYKDEE 269
7tmA_P2Y1 cd15377
P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
38-335 3.64e-11

P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y1 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 341350 [Multi-domain]  Cd Length: 289  Bit Score: 63.78  E-value: 3.64e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  38 IFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTvLPFsAIFEILGY--WAFGRVFCNIWAAVDVLCCTASIM 115
Cdd:cd15377   12 ITGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLT-LPA-LIFYYFNKtdWIFGDAMCKLQRFIFHVNLYGSIL 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 116 GLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALsLVISIGP-LFGWRQQAPEDETI-----CQINEEPGYVLFS- 188
Cdd:cd15377   90 FLTCISVHRYTGVVHPLKSLGRLKKKNAICISVLVWLI-VVVAISPiLFYSGTGVRKNKTItcydtTSDEYLRSYFIYSm 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 189 --ALGSFYVPLTIILVMYCRVyvvakresrgLKSGLKTDKSDSEQVTLRIHRKnvpaegsgvssaknkthfSVRLLKfsr 266
Cdd:cd15377  169 ctTVAMFCVPFILILGCYGLI----------VRALIYKDMKYTEENNAPLRRK------------------SIYLVI--- 217
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755547671 267 ekkaaktlgIVVGCFVLCWLPFFLVMPIG-SFFPNFKPPE---------TVFKIVFWLGYLNSCINPIIYPCSSQEFKK 335
Cdd:cd15377  218 ---------IVLTVFAVSYLPFHVMKTLNlRARLDFQTPAmcafndrvyATYQVTRGLASLNSCVDPILYFLAGDTFRR 287
7tmA_OR6C-like cd15912
olfactory receptor subfamily 6C and related proteins, member of the class A family of ...
27-162 4.15e-11

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320578  Cd Length: 270  Bit Score: 63.27  E-value: 4.15e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPfsaifEILGYWAFGRvfcniwAAVD 106
Cdd:cd15912    1 ILLFLLLLLTYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIP-----KMLANLLSGK------KTIS 69
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755547671 107 VLCCTAS-----IMG------LCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPL 162
Cdd:cd15912   70 FAGCFAQsffyfFLGttefflLAVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPT 136
7tmA_CCR7 cd15175
CC chemokine receptor type 7, member of the class A family of seven-transmembrane G ...
38-204 4.73e-11

CC chemokine receptor type 7, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR7 is a major homeostatic receptor responsible for lymph node development and effective adaptive immune responses and plays a critical role in trafficking of dendritic cells and B and T lymphocytes. Its only two ligands, CCL and CCl21, are primarily produced by stromal cells in the T cell zones of lymph nodes and spleen. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341331 [Multi-domain]  Cd Length: 278  Bit Score: 63.25  E-value: 4.73e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  38 IFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTvLPFSAIfEILGYWAFGRVFCNIWAAVDVLCCTASIMGL 117
Cdd:cd15175   12 FLGLLGNGLVILTYIYFKRLKTMTDIYLLNLALADILFLLT-LPFWAA-SAAKKWVFGEEMCKAVYCLYKMSFFSGMLLL 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 118 CIISIDRYIGVSyplryPTIVTQRRGVRAL-------LCVWALSLVISIGPLFGWRQQAPEDETICQINEEPGYVLFSAL 190
Cdd:cd15175   90 MCISIDRYFAIV-----QAASAHRHRSRAVfiskvssLGVWVLAFILSIPELLYSGVNNNDGNGTCSIFTNNKQTLSVKI 164
                        170       180
                 ....*....|....*....|
gi 755547671 191 GS------FYVPLTIILVMY 204
Cdd:cd15175  165 QIsqmvlgFLVPLVVMSFCY 184
7tmA_BK-1 cd15380
bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled ...
38-334 5.62e-11

bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320502 [Multi-domain]  Cd Length: 286  Bit Score: 63.28  E-value: 5.62e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  38 IFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTsTVLPFSA--IFEILGyWAFGRVFCNIWAAVDVLCCTASIM 115
Cdd:cd15380   12 FFGLLGNLFVLFVFLLPRRRLTIAEIYLANLAASDLVFV-LGLPFWAenIRNQFN-WPFGNFLCRVISGVIKANLFISIF 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 116 GLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIgPLFGWR--QQAPEDETICQINEEP-------GYVL 186
Cdd:cd15380   90 LVVAISQDRYRTLVHTMTSRRQRSRRQAQVICLLIWVFGGLLSI-PTFLFRsvKHVPDLNISACILLFPheawhfaRRVE 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 187 FSALGsFYVPLT-IILVMYCRvyvvakresrglksglktdksdseqvtlrihrknvpaegsgVSSAKNKTHFSVRLLKFS 265
Cdd:cd15380  169 LNIVG-FLLPLAaIVFFNFHI-----------------------------------------IASLRERTEESRKRCGGL 206
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 266 REKKAAKTLGIVVGCFVLCWLPFFLVMpigsfFPNFKPPETVFKIVFW-------------LGYLNSCINPIIYPCSSQE 332
Cdd:cd15380  207 KDTKATRLILTLVLMFLVCWTPYHFFA-----FLDFLFQVEVIQGCFWeefidlglqlanfFAFANSCLNPVIYVFAGKL 281

                 ..
gi 755547671 333 FK 334
Cdd:cd15380  282 FR 283
7tmA_OR13H-like cd15431
olfactory receptor subfamily 13H and related proteins, member of the class A family of ...
36-213 8.66e-11

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320548 [Multi-domain]  Cd Length: 269  Bit Score: 62.24  E-value: 8.66e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  36 LIIFGV--LGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFsAIFEILGYWA---FGRvfCNIWAAVDVLCC 110
Cdd:cd15431    8 LIVYLVtlLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQ-MLVNCLSDRPtisYSR--CLAQMYISLFLG 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 111 TASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWR--------------------QQAP 170
Cdd:cd15431   85 ITECLLLAVMAYDRFVAICNPLRYTLIMSWRVCIQLAAGSWVSAFLLTVIPVLTMPlhfcgpnvinhffcevqallKLAC 164
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 755547671 171 EDETICQIneepgYVLFSALGSFYVPLTIILVMYCRVYVVAKR 213
Cdd:cd15431  165 SDTSLNEI-----LMFATSIFTLLLPFSFILVSYIRIGVAVLR 202
7tmA_CysLTR1 cd15158
cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G ...
38-204 8.74e-11

cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320286 [Multi-domain]  Cd Length: 285  Bit Score: 62.46  E-value: 8.74e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  38 IFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTvLPFSAIFEI-LGYWAFGRVFCNIWA---AVDVLCctaS 113
Cdd:cd15158   12 VFGLVGNGFALYVLIKTYRQKSAFHIYMLNLAVSDLLCVCT-LPLRVVYYVhKGQWLFGDFLCRISSyalYVNLYC---S 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 114 IMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWaLSLVISIGPLFGWRQQAPED-ETIC----QINEEPGYVL-- 186
Cdd:cd15158   88 IYFMTAMSFTRFLAIVFPVQNLNLVTVKKARIVCVGIW-IFVTLTSSPFLMSGSHDTETnKTKCfeppQSNQQLTKLLvl 166
                        170       180
                 ....*....|....*....|
gi 755547671 187 --FSALGSFYVPLTIILVMY 204
Cdd:cd15158  167 nyISLVVGFIIPFLVILICY 186
7tmA_LPAR6_P2Y5 cd15156
lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G ...
28-163 9.24e-11

lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 6 (LPAR6), also known as P2Y5, is a G(i), G(12/13) G protein-coupled receptor that is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively present in serum. LPAR6 plays an important role in maintenance of human hair growth. Thus, mutations in the receptor are responsible for both autosomal recessive wooly hair and hypotrichosis. Phylogenetic analysis of the class A GPCRs shows that LAPR6 (P2Y5) is classified into the cluster consisting of receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production.


Pssm-ID: 320284 [Multi-domain]  Cd Length: 285  Bit Score: 62.56  E-value: 9.24e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  28 LLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTvLPFSAIFEILGYWAFGRVFCNIWAAVDV 107
Cdd:cd15156    2 LYGCVFSMVFVLGLIANCVAIYIFMCTLKVRNETTTYMINLAISDLLFVFT-LPFRIFYFVQRNWPFGDLLCKISVTLFY 80
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 755547671 108 LCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLF 163
Cdd:cd15156   81 TNMYGSILFLTCISVDRFLAIVYPFRSKTLRTKRNAKIVCAAVWLTVLAGSLPASF 136
7tmA_Glyco_hormone_R cd15136
glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...
38-335 9.80e-11

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.


Pssm-ID: 320264 [Multi-domain]  Cd Length: 275  Bit Score: 62.23  E-value: 9.80e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  38 IFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLtSTVLPFSAIFEILGY---------WAFGrVFCNIWAAVDVL 108
Cdd:cd15136   12 LLALVGNIIVLLVLLTSRTKLTVPRFLMCNLAFADFCM-GIYLGLLAIVDAKTLgeyynyaidWQTG-AGCKTAGFLAVF 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 109 CCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFG---WRQQApedetIC-----QINE 180
Cdd:cd15136   90 SSELSVFTLTVITLERWYAITHAMHLNKRLSLRQAAIIMLGGWIFALIMALLPLVGvssYSKTS-----IClpfetETPV 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 181 EPGYVLFSALGSFyVPLTIILVMYCRVYvvakresrglksglktdksdseqvtLRIHrknvpaegsGVSSAKNkthfsvr 260
Cdd:cd15136  165 SKAYVIFLLLFNG-LAFLIICGCYIKIY-------------------------LSVR---------GSGRAAN------- 202
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755547671 261 llkfSREKKAAKTLGIVVGCFVLCWLP--FF-LVMPIGsfFPNFKPPETVFKIVFWLGyLNSCINPIIYPCSSQEFKK 335
Cdd:cd15136  203 ----SNDTRIAKRMALLVFTDFLCWAPiaFFgLTAAFG--LPLISVSNAKILLVFFYP-LNSCANPFLYAIFTKQFRR 273
7tmA_S1PR2_Edg5 cd15347
sphingosine-1-phosphate receptor subtype 2 (S1PR2 or S1P2), also called endothelial ...
41-337 1.06e-10

sphingosine-1-phosphate receptor subtype 2 (S1PR2 or S1P2), also called endothelial differentiation gene 5 (Edg5), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320469 [Multi-domain]  Cd Length: 266  Bit Score: 62.14  E-value: 1.06e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  41 VLGNILVILSVACHRHLHSVTHYYIVNLAVADLL-----LTSTVLPFSAIFEILGYWAFGRVfcniWAAVDVLCctASIM 115
Cdd:cd15347   15 VLENLLVLIAVARNKKFHSAMFFFIGNLAFSDLLagvafIANILLSGSVTFRLTPVQWFIRE----GTAFITLS--ASVF 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 116 GLCIISIDRYIGVSYPLRYPTivtqRRGVRALLCV---WALSLVISIGPLFGWR--QQAPEDETICQINEEPgYVLFsAL 190
Cdd:cd15347   89 SLLAIAIERHVAITKVKLYGS----DKNCRMVLLIgacWVISIVLGGLPILGWNciGNLEDCSTVLPLYSKH-YILF-VV 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 191 GSFYVPLTIILVMYCRVYVVAkRESRGLKSGLKTdksdseqvtlrihrknvpaegsgvssaknkthfsVRLLkfsrekka 270
Cdd:cd15347  163 TIFSIILLSIVILYVRIYCIV-RSSHAEMAAPQT----------------------------------LALL-------- 199
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755547671 271 aKTLGIVVGCFVLCWLPFFLVMPIGSFFPnFKPPETVFK--IVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15347  200 -KTVTIVLGVFIVCWLPAFIILLLDTSCK-VKSCPILYKadYFFSVATLNSALNPVIYTLRSKDMRKEF 266
PHA02834 PHA02834
chemokine receptor-like protein; Provisional
36-352 1.15e-10

chemokine receptor-like protein; Provisional


Pssm-ID: 165177  Cd Length: 323  Bit Score: 62.61  E-value: 1.15e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  36 LIIFGVLGNILVILSVACHRHLHSVThYYIVNLAVADLLLTSTvLPFsAIFEILGYWAFGRVFCNIWAAVDVLCCTASIM 115
Cdd:PHA02834  38 LFIFGLIGNVLVIAVLIVKRFMFVVD-VYLFNIAMSDLMLVFS-FPF-IIHNDLNEWIFGEFMCKLVLGVYFVGFFSNMF 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 116 GLCIISIDRYIGVsypLRYPTIVTQRRGVRALLCV--WALSLVISIGPLFGWRQQAPEDETICQINEEPGYVLFSALGSF 193
Cdd:PHA02834 115 FVTLISIDRYILV---VNATKIKNKSISLSVLLSVaaWVCSVILSMPAMVLYYVDNTDNLKQCIFNDYHENFSWSAFFNF 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 194 -------YVPLTIILVMYCRVYVVAKresrglksglktdksdseqvtlrihrknvpaegsgvsSAKNKThfsvrllkfsr 266
Cdd:PHA02834 192 einifgiVIPLIILIYCYSKILYTLK-------------------------------------NCKNKN----------- 223
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 267 EKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFP---------NFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:PHA02834 224 KTRSIKIILTVVTFTVVFWVPFNIVLFINSLQSvglidigcyHFKKIVYSIDIAELISFVHCCVNPIIYAFVGKNFKKVF 303
                        330
                 ....*....|....*.
gi 755547671 338 QNVL-RIQCLRRRQSS 352
Cdd:PHA02834 304 KNMFcRTNNIFIRQSS 319
7tmA_PAR4 cd15372
protease-activated receptor 4, member of the class A family of seven-transmembrane G ...
64-207 1.18e-10

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320494 [Multi-domain]  Cd Length: 274  Bit Score: 62.07  E-value: 1.18e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  64 YIVNLAVADLLLTStVLPFSAIFEILG-YWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRR 142
Cdd:cd15372   37 FLINLAVADLLLIL-VLPFKISYHFLGnNWPFGEGLCRVVTAFFYGNMYCSVLLLMCISLDRYLAVVHPFFARTLRSRRF 115
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755547671 143 GVRALLCVWaLSLVISIGPLFGWRQQAP---EDETICQ----INEEPGYVLFS----ALGSFYVPLTIILVMYCRV 207
Cdd:cd15372  116 ALCMCTAIW-LIAAALTLPLTLQRQSYPlerLNITLCHdvlpLDEQDTYLFYYfaclAVLGFLLPLVVILFCYGSV 190
7tmA_ACKR3_CXCR7 cd14987
CXC chemokine receptor 7, member of the class A family of seven-transmembrane G ...
36-205 1.18e-10

CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR3, also known as CXCR7, is an atypical chemokine receptor for CXCL12 and CXCR11. Unlike the classical chemokine receptors, ACKR3 contains a DRYLSIT-sequence instead of the conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. Thus, ACKR3 does not activate classical GPCR signaling, instead induces beta-arrestin recruitment which is leading to ligand internalization and MAP-kinase activation. It is acting as a scavenger for CXCL12 and, to a lesser degree, for CXCL11. ACKR3 is highly expressed by blood vascular endothelial cells in brain, in numerous embryonic and neonatal tissues, in inflamed tissues and in a variety of cancers such as lymphomas, sarcomas, prostate and breast cancers, and gliomas. Five receptors have been identified for the ACKR family, including CC-Chemokine Receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, DARC, and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320118 [Multi-domain]  Cd Length: 282  Bit Score: 62.08  E-value: 1.18e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  36 LIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIM 115
Cdd:cd14987   10 IFVIGLLANSVVVWVNLQAKRTGYETHLYILNLAIADLCVVATLPVWVVSLVQHNQWPMGEFTCKITHLIFSINLFGSIF 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 116 GLCIISIDRYIGVSYplrYPTIVTQRRG-VRALLC--VWALSLVISIGPLFGWR--QQAPEDETICQIN--EEP------ 182
Cdd:cd14987   90 FLTCMSVDRYLSVTL---FGNTSSRRKKiVRRIICvlVWLLAFVASLPDTYFLKtvTSPSNNETYCRSFypEESfkewli 166
                        170       180
                 ....*....|....*....|...
gi 755547671 183 GYVLFSALGSFYVPLTIILVMYC 205
Cdd:cd14987  167 GMELVSIVLGFVIPFPIIAVFYF 189
7tmA_PAR1 cd15369
protease-activated receptor 1, member of the class A family of seven-transmembrane G ...
35-207 1.52e-10

protease-activated receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320491  Cd Length: 281  Bit Score: 61.71  E-value: 1.52e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  35 GLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTStVLPFSAIFEILGY-WAFGRVFCNIWAAVDVLCCTAS 113
Cdd:cd15369    9 IVFVISLPLNILALVVFLRKMRVKKPAVIYMLNLACADLLFVL-LLPFKIAYHFSGNdWLFGEAMCRVVTAAFYCNMYCS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 114 IMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIgPLFGWRQ--QAPE-DETICQ----INEEPGY-- 184
Cdd:cd15369   88 ILLMTCISVDRFLAVVYPMQSLSWRTLRRASFTCAAIWLLSIAGVV-PLLLSEQtiQIPDlGITTCHdvlnEQLLMGYyv 166
                        170       180
                 ....*....|....*....|....*
gi 755547671 185 VLFSALGS--FYVPLTIILVMYCRV 207
Cdd:cd15369  167 YYFSIFSClfFFVPLIITTVCYVSI 191
7tmA_P2Y4 cd15374
P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled ...
27-326 1.96e-10

P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y4 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320496 [Multi-domain]  Cd Length: 285  Bit Score: 61.36  E-value: 1.96e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVD 106
Cdd:cd15374    1 ILLPVSYGLVFVVGLPLNATALWLFIKRMRPWNPTTVYMFHLALSDTLYVLSLPTLIYYYADHNHWPFGVVACKIVRFLF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQAPEDETICQINEEP---- 182
Cdd:cd15374   81 YANLYCSILFLTCISVHRYVGICHPIRALRWVKPRHAYLICASVWLVVTVCLVPNLIFVTTSRKDNITLCHDTTRPeefd 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 183 GYVLFSALGS---FYVPLTIILVMYCrvyvvakresrglksglktdksdseQVTLRIHRKNVPAEGSGVSSAKnkthfsv 259
Cdd:cd15374  161 HYVHYSSAVMvllFGIPCLVIVVCYG-------------------------LMARRLCKPRVGSSRQQGPSSK------- 208
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755547671 260 rllkfsreKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPP-------ETVFKIVFWLGYLNSCINPIIY 326
Cdd:cd15374  209 --------KRSLKTIIMVLTVFAICFVPFHITRTLYYVARLLKADcdtlniiNVTYKVTRPLASANSCLDPILY 274
7tmA_CCR3 cd15185
CC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
38-335 3.31e-10

CC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR3 is a highly promiscuous receptor that binds a variety of inflammatory CC-type chemokines, including CCL11 (eotaxin-1), CCL3L1, CCL5 (regulated on activation, normal T cell expressed and secreted; RANTES), CCL7 (monocyte-specific chemokine 3 or MCP-3), CCL8 (MCP-2), CCL11, CCL13 (MCP-4), CCL15, CCL24 (eotaxin-2), CCL26 (eotaxin-3), and CCL28. Among these, the eosinophil chemotactic chemokines (CCL11, CCL24, and CCL26) are the most potent and specific ligands. In addition to eosinophil, CCR3 is expressed on cells involved in allergic responses, such as basophils, Th2 lymphocytes, and mast cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341339 [Multi-domain]  Cd Length: 278  Bit Score: 60.61  E-value: 3.31e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  38 IFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTvLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMGL 117
Cdd:cd15185   12 IVGLLGNVVVVVILIKYRRLRIMTNIYLLNLAISDLLFLFT-LPFWIHYVRWNNWVFGHGMCKLLSGFYYLGLYSEIFFI 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 118 CIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQAPEDETICQI----NEEPGYVLFSALG-- 191
Cdd:cd15185   91 ILLTIDRYLAIVHAVFALRARTVTFGIITSIITWGLAVLAALPEFIFYETQELFEEFLCSPlypeDTEDSWKRFHALRmn 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 192 --SFYVPLTIILVMYCRVyvvakresrglksgLKTdksdseqvTLRIHRKnvpaegsgvssaknkthfsvrllkfsREKK 269
Cdd:cd15185  171 ifGLALPLLIMVICYTGI--------------IKT--------LLRCPSK--------------------------KKYK 202
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755547671 270 AAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNF--------KPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKK 335
Cdd:cd15185  203 AIRLIFVIMVVFFIFWTPYNLVLLLSAFQSIFfetdcersKHLDLAMQVTEVIAYTHCCINPVIYAFVGERFRK 276
7tmA_CCR5_CCR2 cd15184
CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G ...
36-335 4.34e-10

CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR2 and CCR5 share very high amino acid sequence identity. Both receptors play important roles in the trafficking of monocytes/macrophages and are implicated in the pathogenesis of immunologic diseases (rheumatoid arthritis, celiac disease, and transplant rejection) and cardiovascular diseases (atherosclerosis and autoimmune hepatitis). CCR2 is a receptor specific for members of the monocyte chemotactic protein family, including CCL2, CCL7, and CCL13. Conversely, CCR5 is a major co-receptor for HIV infection and binds many CC chemokine ligands, including CC chemokine ligands including CCL2, CCL3, CCL4, CCL5, CCL11, CCL13, CCL14, and CCL16. CCR2 is expressed primarily on blood monocytes and memory T cells, whereas CCR5 is expressed on antigen-presenting cells (macrophages and dendritic cells) and activated T effector cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341338 [Multi-domain]  Cd Length: 278  Bit Score: 60.15  E-value: 4.34e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  36 LIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTvLPFSAIFEIlGYWAFGRVFCNIWAAVDVLCCTASIM 115
Cdd:cd15184   10 VFIFGFVGNMLVVLILINCKKLKSMTDIYLLNLAISDLLFLLT-LPFWAHYAA-NEWVFGNAMCKLLTGLYHIGFFSGIF 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 116 GLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQAPEDETICQINEEP----GYVLFSALG 191
Cdd:cd15184   88 FIILLTIDRYLAIVHAVFALKARTVTFGVVTSVVTWVVAVFASLPGIIFTKSQKEGSHYTCSPHFPPsqyqFWKNFQTLK 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 192 ----SFYVPLTIILVMYCRVyvvakresrglksgLKTdksdseqvtlrihrknvpaegsgvssaknkthfSVRLLKFSRE 267
Cdd:cd15184  168 mnilGLVLPLLVMIICYSGI--------------LKT---------------------------------LLRCRNEKKR 200
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755547671 268 KKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPP--------ETVFKIVFWLGYLNSCINPIIYPCSSQEFKK 335
Cdd:cd15184  201 HKAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFGLNncsssnrlDQAMQVTETLGMTHCCINPVIYAFVGEKFRS 276
7tmA_GPR6 cd15962
G protein-coupled receptor 6, member of the class A family of seven-transmembrane G ...
111-336 4.44e-10

G protein-coupled receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320628 [Multi-domain]  Cd Length: 268  Bit Score: 60.33  E-value: 4.44e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 111 TASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWrqQAPEDETICQINE---EPGYVLF 187
Cdd:cd15962   81 TASVSSLLAITVDRYLSLYNALTYYSEKTVLGVHLMLAATWGVSLCLGLLPVLGW--NCLEERASCSIVRpltKSNVTLL 158
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 188 SAlgSFYVPLTIILVMYCRVYVVAKRESrglksglktdksdsEQVTLRIHRKNVPaegsgvssaknkthfsvrllKFSRE 267
Cdd:cd15962  159 SA--SFFFIFILMLHLYIKICKIVCRHA--------------HQIALQQHFLTAS--------------------HYVAT 202
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 268 KKAAKTLGIVVGCFVLCWLPFFLVMPIGSF-FPNFKPPETVFKIVFwlgylNSCINPIIYPCSSQEFKKA 336
Cdd:cd15962  203 KKGVSTLAIILGTFGASWLPFAIYCVVGDHeYPAVYTYATLLPATY-----NSMINPIIYAYRNQEIQRS 267
7tmA_Retinal_GPR cd15072
retinal G protein coupled receptor, member of the class A family of seven-transmembrane G ...
28-216 4.87e-10

retinal G protein coupled receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the retinal G-protein coupled receptor (RGR) found exclusively in retinal pigment epithelium (RPE) and Muller cells. RGR is a member of the class A rhodopsin-like receptor family. As with other opsins, RGR binds all-trans retinal and contains a conserved lysine reside on the seventh helix. RGR functions as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. Two mutations in RGR gene are found in patients with retinitis pigmentosa, indicating that RGR is essential to the visual process.


Pssm-ID: 320200 [Multi-domain]  Cd Length: 260  Bit Score: 60.07  E-value: 4.87e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  28 LLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVAD--LLLTSTVLPFSAifeILGYWAFGRVFCNIWAAV 105
Cdd:cd15072    2 AVGSILLVEALVGFSLNGLTILSFCKTRELRTPSNLLVLSLAVADmgISLNALVAASSS---LLRRWPYGSEGCQAHGFQ 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 106 DVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTqrrgVRALLCVWALSLVISIGPLFGWRQQAPED-ETICQINEEPG- 183
Cdd:cd15072   79 GFFTALASICSSAAIAWDRYHHYCTRSKLQWSTA----ISLVLFVWLFSAFWAAMPLLGWGEYDYEPlGTCCTLDYSKGd 154
                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 755547671 184 -----YVLFSALGSFYVPLTIILVMYCRVYVVAKRESR 216
Cdd:cd15072  155 rnyvsYLFTMAFFNFILPLFILLTSYSSIEQKLKKEGH 192
7tmA_OR14-like cd15227
olfactory receptor family 14 and related proteins, member of the class A family of ...
27-159 5.14e-10

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320355  Cd Length: 270  Bit Score: 60.16  E-value: 5.14e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWA---FG---RVFCn 100
Cdd:cd15227    1 ILHFVLFLLIYLAALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVTVPKSIANSLTNTRSisfLGcvaQVFL- 79
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 101 iwaavdVLCCTASIMG-LCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISI 159
Cdd:cd15227   80 ------FIFFAASELAlLTVMAYDRYVAICHPLHYEVIMNRGACVQMAAASWLSGLLYGA 133
7tmA_VA_opsin cd15082
non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...
44-337 5.61e-10

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320210 [Multi-domain]  Cd Length: 291  Bit Score: 60.20  E-value: 5.61e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  44 NILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISID 123
Cdd:cd15082   31 NFAVMLVTFRFKQLRQPLNYIIVNLSVADFLVSLTGGTISFLTNARGYFFLGVWACVLEGFAVTFFGIVALWSLAVLAFE 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 124 RYIGVSYPLRYPTIvTQRRGVRALLCVWALSLVISIGPLFGWRQQAPED-ETICQINEEPG------YVLFSALGSFYVP 196
Cdd:cd15082  111 RFFVICRPLGNIRL-QGKHAALGLLFVWTFSFIWTIPPVLGWSSYTVSKiGTTCEPNWYSGnmhdhtYIITFFTTCFILP 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 197 LTIILVMYCRVYvvakresrglksgLKTDKSDSEQVTLRIHRKNvpaegsgvssaknkthfsvrllkfsrEKKAAKTLGI 276
Cdd:cd15082  190 LGVIFVSYGKLL-------------QKLRKVSNTQGRLGNARKP--------------------------ERQVTRMVVV 230
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755547671 277 VVGCFVLCWLPFFLVMPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15082  231 MIVAFMVCWTPYAAFSILVTAHPTIHLDPRLAAIPAFFSKTAAVYNPIIYVFMNKQFRKCL 291
7tmA_LWS_opsin cd15081
long wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
36-334 7.08e-10

long wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Long Wave-Sensitive opsin is also called red-sensitive opsin or red cone photoreceptor pigment, which mediates visual transduction in response to light at long wavelengths. Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320209 [Multi-domain]  Cd Length: 292  Bit Score: 59.92  E-value: 7.08e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  36 LIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIM 115
Cdd:cd15081   22 VVFASVFTNGLVLVATLKFKKLRHPLNWILVNLAIADLGETVIASTISVVNQIFGYFILGHPMCVLEGFTVSVCGITGLW 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 116 GLCIISIDRYIGVSYP---LRYptivTQRRGVRALLCVWALSLVISIGPLFGWRQQAPED-ETIC-----QINEEPG--- 183
Cdd:cd15081  102 SLTIISWERWVVVCKPfgnIKF----DGKLAIVGIIFSWVWSAVWCAPPIFGWSRYWPHGlKTSCgpdvfSGSSDPGvqs 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 184 YVLFSALGSFYVPLTIILVMYCRVYVVAKRESRGLKSGLKTDKSdseqvtlrihrknvpaegsgvssaknkthfsvrllk 263
Cdd:cd15081  178 YMIVLMITCCIIPLAIIILCYLQVWLAIRAVAQQQKESESTQKA------------------------------------ 221
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755547671 264 fsrEKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFK 334
Cdd:cd15081  222 ---EKEVSRMVVVMIFAYCFCWGPYTFFACFAAANPGYAFHPLAAALPAYFAKSATIYNPIIYVFMNRQFR 289
7tmA_OR1_7-like cd15918
olfactory receptor families 1, 7, and related proteins, member of the class A family of ...
28-158 1.16e-09

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320584 [Multi-domain]  Cd Length: 270  Bit Score: 58.78  E-value: 1.16e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  28 LLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPfsaifeilgywafgRVFCNIWA---A 104
Cdd:cd15918    2 LLFGLFLGMYLVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVP--------------KMLVNIQTqskS 67
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755547671 105 VDVLCCTASI-----------MGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVIS 158
Cdd:cd15918   68 ISYAGCLTQMyffllfgdldnFLLAVMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHS 132
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
27-158 1.48e-09

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 58.81  E-value: 1.48e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPfsaifEILGYWAFGR---------- 96
Cdd:cd15232    1 VLLFWLFLFLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVP-----KLLQNLLTERktisfggcma 75
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755547671  97 -VFCNIWAAVdvlcctASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVIS 158
Cdd:cd15232   76 qLYFFTWSLG------SELLLLTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNS 132
7tmA_OR2D-like cd15428
olfactory receptor subfamily 2D and related proteins, member of the class A family of ...
27-159 1.86e-09

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320545 [Multi-domain]  Cd Length: 277  Bit Score: 58.26  E-value: 1.86e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPfsaifEILGYW-------AFGRVFC 99
Cdd:cd15428    1 ILLFILFLIIYLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVP-----QMLVHLlserkiiSFIRCAA 75
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 100 NIWAAVDVLCCTASImgLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISI 159
Cdd:cd15428   76 QLYFFLSFGITECAL--LSVMSYDRYVAICLPLRYSLIMTWKVCISLATGSWVGGLLVSA 133
7tmA_GPR3 cd15963
G protein-coupled receptor 3, member of the class A family of seven-transmembrane G ...
65-335 1.93e-09

G protein-coupled receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320629 [Multi-domain]  Cd Length: 268  Bit Score: 58.36  E-value: 1.93e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  65 IVNLAVADLLL-TSTVLPFSAIfeilgYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRG 143
Cdd:cd15963   39 IGSLATADLLAgLGLILHFAFV-----YCIQSAPVNLVTVGLLAPSFTASVSSLLAITIDRYLSLYNALTYYSERTVTRT 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 144 VRALLCVWALSLVISIGPLFGWrqQAPEDETICQINE---EPGYVLFSAlgSFYVPLTIILVMYCRVYVVAKRESrglks 220
Cdd:cd15963  114 YIMLILTWGASLCLGLLPVVGW--NCLKDPSTCSVVKpltKNHLVILSI--SFFMVFALMLQLYAQICRIVCRHA----- 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 221 glktdksdsEQVTLRIHrknvpaegsgvssaknkthfSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFfpn 300
Cdd:cd15963  185 ---------HQIALQRH--------------------FLPTSHYVTTRKGIATLAVILGTFASCWLPFAVYCLLGDY--- 232
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 755547671 301 FKPPETVFKIVFWLGYlNSCINPIIYPCSSQEFKK 335
Cdd:cd15963  233 TYPALYTYATLLPATY-NSMINPIIYAFRNQEIQK 266
7tmA_LPAR1_Edg2 cd15344
lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial ...
38-337 2.57e-09

lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 341348 [Multi-domain]  Cd Length: 273  Bit Score: 58.11  E-value: 2.57e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  38 IFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLltSTVLPFSAIFEILGYWAfgRVFCNIWAAVDVL---CCTASI 114
Cdd:cd15344   12 IFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFF--AGLAYFYLMFNTGPNTR--RLTVSTWLLRQGLidtSLTASV 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 115 MGLCIISIDRYIGVsYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWrqqapedETICQI----NEEP----GYVL 186
Cdd:cd15344   88 ANLLAIAIERHITV-FRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGW-------NCICDIencsNMAPlysdSYLV 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 187 FSALGSFyVPLTIILVMYCRVYVVAKresrglksglktdksdseQVTLRIHRknvpaegsgvssaknktHFSVRLLKFSR 266
Cdd:cd15344  160 FWAIFNL-VTFVVMVVLYAHIFGYVR------------------QRTMRMSR-----------------HSSGPRRNRDT 203
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755547671 267 EKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKpPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15344  204 MMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCD-VLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATF 273
7tmA_ACKR2_D6 cd15188
atypical chemokine receptor 2, member of the class A family of seven-transmembrane G ...
27-223 3.73e-09

atypical chemokine receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR2 (also known as D6) binds non-selectively to all inflammatory CC-chemokines, but not to homeostatic CC-chemokines involved in controlling the migration of cells. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320316 [Multi-domain]  Cd Length: 278  Bit Score: 57.49  E-value: 3.73e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACH-RHLHSVTHYYIVNLAVADLLLTSTvLPFSAIFeILGYWAFGRVFCNIWAAV 105
Cdd:cd15188    1 VFLPVFYTLVFLLGLAGNLLLFVVLLLYvPKKKKMTEVYLLNLAVSDLLFLVT-LPFWAMY-VAWHWVFGSFLCKFVSTL 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 106 DVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGP-LFGWRQQAPEDETICQIN---EE 181
Cdd:cd15188   79 YTINFYSGIFFVSCMSLDKYLEIVHAQSPHRLRTRRKSLLVLVAVWVLSIALSVPDmVFVQTHHTNNGVWVCHADyggHH 158
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 755547671 182 PGYVLF----SALGSFYVPLTIILVMYCRVYVVAKR-ESRGLKSGLK 223
Cdd:cd15188  159 TIWKLVfqfqQNLLGFLFPLLAMVFFYSRIACVLTRlRPPGQGRALR 205
7tmA_ET-BR cd15976
endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
36-337 4.24e-09

endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320642 [Multi-domain]  Cd Length: 296  Bit Score: 57.56  E-value: 4.24e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  36 LIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIM 115
Cdd:cd15976   10 VFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIIIDIPINVYKLLAEDWPFGVEMCKLVPFIQKASVGITVL 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 116 GLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGW----RQQAPEDETICQIN--EEPGYVLFSA 189
Cdd:cd15976   90 SLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSIILAVPEAIGFdmitMDYKGELLRICLLHpiQKTAFMQFYK 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 190 ------LGSFY--VPLTIILVMYcrvyvvakresrglksglktdksdsEQVTLRIHRKNvpaegSGVSSAKNKThfsvrl 261
Cdd:cd15976  170 takdwwLFSFYfcLPLACTAVFY-------------------------TLMTCEMLRKK-----NGMQIALNDH------ 213
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 262 LKFSREkkAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPETVFKIVFWL---------GYLNSCINPIIYPCSSQE 332
Cdd:cd15976  214 LKQRRE--VAKTVFCLVLVFALCWLPLHLSRILKLTIYDEKDPNRCELLSFFLvldyiginmASLNSCINPIALYLVSKR 291

                 ....*
gi 755547671 333 FKKAF 337
Cdd:cd15976  292 FKNCF 296
7tmA_OR7-like cd15234
olfactory receptor family 7 and related proteins, member of the class A family of ...
41-158 4.31e-09

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320362 [Multi-domain]  Cd Length: 277  Bit Score: 57.20  E-value: 4.31e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  41 VLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPfsaifeilgywafgRVFCNIWA---AVDVLCCTASI--- 114
Cdd:cd15234   15 VLGNLLIILAVSSDSHLHTPMYFFLSNLSFADICFSSTTVP--------------KMLVNIQTqskSISYTGCLTQMcff 80
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 755547671 115 -----MGLCIISI---DRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVIS 158
Cdd:cd15234   81 llfggLDNFLLAVmayDRYVAICHPLHYTVIMNPCLCGLLVLLSLLISILDS 132
7tmA_PGE2_EP4 cd15142
prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G ...
36-244 4.32e-09

prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin E2 receptor EP4, also called prostanoid EP4 receptor, is one of four receptor subtypes whose endogenous physiological ligand is prostaglandin E2 (PGE2). Each of these subtypes (EP1-EP4) have unique but overlapping tissue distributions that activate different intracellular signaling pathways. Like the EP2 receptor, stimulation of the EP4 receptor by PGE2 causes cAMP accumulation through G(s) protein activation. Knockout studies in mice suggest that EP4 receptor may be involved in the maintenance of bone mass and fracture healing. Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320270 [Multi-domain]  Cd Length: 302  Bit Score: 57.51  E-value: 4.32e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  36 LIIFGVLGNILVILSVACHRHLHSVTHYY--IVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTAS 113
Cdd:cd15142   10 MFIFGVVGNLIAIVVLCKSRKEQKETTFYtlVCGLAVTDLLGTCLASPVTIATYLKGRWPGGQPLCEYFSFILLFFSLSG 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 114 IMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGW-RQQAPEDETICQIN---EEPGYVLFSA 189
Cdd:cd15142   90 LSIICAMSIERYLAINHAYFYNHYVDKRLAGLTLFAIYASNILFCALPSMGLgKSKLQYPKTWCFIDwrtNVSVHAAYSY 169
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 190 L----GSFYVPLTIIL-VMYCRVYVVAKRESRGLKSgLKTDKSDSEQVTLRIHRKNVPAE 244
Cdd:cd15142  170 MyagfSSLLILVTVLCnVLVCGALIRMHRQFVRRTS-LGTDQRLSDFRRRRSFRRMAGAE 228
7tmA_OR56-like cd15223
olfactory receptor family 56 and related proteins, member of the class A family of ...
36-148 4.91e-09

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320351 [Multi-domain]  Cd Length: 279  Bit Score: 57.30  E-value: 4.91e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  36 LIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPfsAIFEILGYWA----FGRVFCNIWAAVDVLCCT 111
Cdd:cd15223   10 LYLVALVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILP--KMLAIFWFDAntisLPGCFAQMFFIHFFTAME 87
                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 755547671 112 ASImgLCIISIDRYIGVSYPLRYPTIVTQRRGVRALL 148
Cdd:cd15223   88 SSI--LLVMALDRYVAICKPLRYPSIITKSFILKLVL 122
7tmA_NAGly_R_GPR18 cd15166
N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G ...
36-163 5.51e-09

N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G protein-coupled receptors; N-arachidonyl glycine (NAGly), an endogenous metabolite of the endocannabinoid anandamide, has been identified as an endogenous ligand of the G(i/o) protein-coupled receptor 18 (GPR18). NAGly is involved in directing microglial migration in the CNS through activation of GPR18. NAGly-GPR18 signaling is thought to play an important role in microglial-neuronal communication. Recent studies also show that GPR18 functions as the abnormal cannabidiol (Abn-CBD) receptor. Abn-CBD is a synthetic isomer of cannabidiol and is inactive at cannabinoid receptors (CB1 or CB2), but acts as a selective agonist at GPR18. The NAGly receptor is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320294 [Multi-domain]  Cd Length: 275  Bit Score: 57.14  E-value: 5.51e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  36 LIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTvLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIM 115
Cdd:cd15166   10 IFIIGLFVNITALWVFSCTTKKRTTVTVYMMNVALVDLIFILS-LPFRMVYYAKDEWPFGDYFCRILGALTVFYPSIALW 88
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 755547671 116 GLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLF 163
Cdd:cd15166   89 LLAFISADRYMAIVQPKHAKELKNTPKAVLACVGVWIMTLASTFPLLF 136
7tmA_OR11A-like cd15911
olfactory receptor subfamily 11A and related proteins, member of the class A family of ...
38-159 6.24e-09

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320577  Cd Length: 270  Bit Score: 56.72  E-value: 6.24e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  38 IFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLP--------------FSAIfeILGYWAFGrvfcnIWA 103
Cdd:cd15911   12 IVTMAGNILIIVLVVADRHLHTPMYFFLGNLSCLEICYTSTILPrmlaslltgdrtisVSGC--IVQFYFFG-----SLA 84
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 755547671 104 AVDvlCCTASIMglciiSIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISI 159
Cdd:cd15911   85 ATE--CYLLAVM-----SYDRYLAICKPLHYASLMNGRLCLQLAAGSWISGFLAST 133
7tmA_PAFR cd15147
platelet-activating factor receptor, member of the class A family of seven-transmembrane G ...
27-163 7.58e-09

platelet-activating factor receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The platelet-activating factor receptor is a G(q/11)-protein coupled receptor, which is linked to p38 MAPK and PI3K signaling pathways. PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) which is synthesized by cells especially involved in host defense such as platelets, macrophages, neutrophils, and monocytes. PAF is well-known for its ability to induce platelet aggregation and anaphylaxis, and also plays important roles in allergy, asthma, and inflammatory responses, among many others.


Pssm-ID: 320275 [Multi-domain]  Cd Length: 291  Bit Score: 56.68  E-value: 7.58e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVAC---HRHLHSVtHYYIVNLAVADLLLTSTvLPFSAIFEI-LGYWAFGRVFCNIW 102
Cdd:cd15147    1 TLFPIVYSIIFVLGLIANCYVLWVFARlypSKKLNEI-KIFMVNLTIADLLFLIT-LPFWIVYYHnEGNWILPKFLCNVA 78
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755547671 103 AAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLF 163
Cdd:cd15147   79 GCLFFINTYCSVAFLGVISYNRYQAVTRPIKTAQSTTRKRGIIISVAIWVIIVASASYFLF 139
7tmA_OXER1 cd15200
oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G ...
32-333 8.15e-09

oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; OXER1, also called GPR170, is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. OXER1 is a member of the class A family of seven-transmembrane G-protein coupled receptors and appears to be coupled to the G(i/o) protein. The receptor is expressed in various tissues except brain. Phylogenetic analysis showed that GPR31 and OXER1 are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). OXER1, like GPR31, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike GPR31, does cause increase in the cytosolic calcium level.


Pssm-ID: 320328 [Multi-domain]  Cd Length: 276  Bit Score: 56.32  E-value: 8.15e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  32 ILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTvLPFSAIFEILG-YWAFGRVFCNIWAAVDVLCC 110
Cdd:cd15200    6 VLGIEFVLGLVGNGIALFIFCFHRRPWKSNTMYLLSLVVADFFLIIN-LPFRIDYYLRNeVWRFGATACQVNLFMLSMNR 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 111 TASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIgPLFgwRQQAPEDETIC---QINEEPG---- 183
Cdd:cd15200   85 TASIVFLTAIALNRYLKVVHPHHQLSKASVGCAAKVAAGLWILILLLNI-HLL--LLDHVQSNSTClsyDHGTDPSasdr 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 184 --YVLFsaLGSFYVPLTIIlvMYCRVYVVAKRESRGLKSGLKTdksdseqvtlrihrknvpaegsgvssaknkthfsvrl 261
Cdd:cd15200  162 whRILF--FLEFFLPLGII--LFCIFSIILTLKQRKLAKQAGP------------------------------------- 200
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755547671 262 lkfsreKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPET------VFKIVFWLGYLNSCINPIIYPCSSQEF 333
Cdd:cd15200  201 ------QRAVKVLAVIVLVYTVCFLPSILFALASLVAFKVSQCRSldlctqLFHGSLAFTYLNSALDPVLYCFSSPSF 272
7tmA_GPR88-like cd15211
G protein-coupled receptor 88, member of the class A family of seven-transmembrane G ...
28-337 1.00e-08

G protein-coupled receptor 88, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR88, an orphan G protein-coupled receptor, is predominantly and almost exclusively expressed within medium spiny neurons (MSNs) of the brain's striatum in both human and rodents; thus it is also called Striatum-specific GPCR (STRG). The striatum is known to involve in motor coordination, reward-based decision making, and response learning. GPR88 is shown to co-localize with both dopamine D1 and D2 receptors and displays the highest sequence similarity to receptors for biogenic amines such as dopamine and serotonin. GPR88 knockout mice showed abnormal behaviors observed in schizophrenia, such as disrupted sensorimotor gating, increased stereotypic behavior and locomotor activity in response to treatment with dopaminergic compounds such as apomorphine and amphetamine, respectively, suggesting a role for GPR88 in dopaminergic signaling. Furthermore, the transcriptional profiling studies showed that GPR88 expression is altered in a number of psychiatric disorders such as depression, drug addiction, bipolar and schizophrenia, providing further evidence that GPR88 plays an important role in CNS signaling pathways related to psychiatric disorder. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320339 [Multi-domain]  Cd Length: 283  Bit Score: 56.40  E-value: 1.00e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  28 LLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFG--RVFcniWAAV 105
Cdd:cd15211    1 SLSTVYSFLAVSGTLANVLVIYLVVSFKKLQTTSNAFIVNGCVADLLVCAFWMPQEAVLGSTGTLLVLgyRLF---REGL 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 106 DVLCCTASIMGLCIISIDRYIGVSyplRYPTI---VTQRRGVRallCVWALSLVISIGPLFGWRQQAPEDETICQINEEP 182
Cdd:cd15211   78 LFLGLTVSLLSHSLIALNRYVLIT---KLPAVyqaLYQKRNTE---WMIALSWALALGLLLPWLTSFRYPTKSCHDSADG 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 183 GYVLFSALGSFYVPLTI--------ILVMYCRVYVVAKresrglksglktdksdseqvtLRIHRKNVpaegsgvsSAKNK 254
Cdd:cd15211  152 SFAVVSVLSSRYPALLLaftvlgqtALVLHCYFGIFRR---------------------VQISVKRV--------SVLNF 202
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 255 THFSVRLLKFSREKKAAKTLGIVVGC-FVLCWLPFFLVMPIGSFFPnfkPPETVFKIVFWLGYLNSCINPIIYPCSSQEF 333
Cdd:cd15211  203 QIVNNLPYSRPRKDKRLGLYVLLVCCvFLLTTEPLVWVSLAGLFVP---VPVALQTASWLLFCTLFVLNPFLYTWKNEEF 279

                 ....
gi 755547671 334 KKAF 337
Cdd:cd15211  280 RRSF 283
7tmA_GPER1 cd14989
G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G ...
36-334 1.18e-08

G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled estrogen receptor 1 (GPER1), also known as the G-protein coupled receptor 30 (GPR30), is a high affinity receptor for estrogen. This receptor is a member of the class A of seven-transmembrane GPCRs. Estrogen binding results in intracellular calcium mobilization and synthesis of phosphatidylinositol (3,4,5)-trisphosphate in the nucleus. GPR30 plays an important role in development of tamoxifen resistance in breast cancer cells. The distribution of GPR30 is well established in the rodent, with high expression observed in the hypothalamus, pituitary gland, adrenal medulla, kidney medulla and developing follicles of the ovary. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320120 [Multi-domain]  Cd Length: 276  Bit Score: 55.99  E-value: 1.18e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  36 LIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLpfSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIM 115
Cdd:cd14989   10 LFPIGFIGNILILVVNLSFREKMTIPDLYFVNLAVADLILVADSL--IEVFNLNEKYYDIAVLCTFMSLFLQINMYSSIF 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 116 GLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQAPEDETICQINEEPGYVLFSALGsFYV 195
Cdd:cd14989   88 FLTWMSFDRYIALAKVMKSSPLRTMQHARLSCGLIWMASISATLLPFTAVQAQHTGEVHFCFADVREIQWLEVTLG-FII 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 196 PLTIILVMYCRVYvvakresrglksglktdksdseQVTLRIHRknvpaegsgvssaknktHFSVRLlkfsREKKAAKTLG 275
Cdd:cd14989  167 PFSIIGLCYSLIV----------------------RVLVRAQK-----------------HRRLRP----RRQKALRMIL 203
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 276 IVVGCFVLCWLP---FFLVMPIGSFFPNFKPPETVFK--------IVFWLGYLNSCINPIIYPCSSQEFK 334
Cdd:cd14989  204 VVVLVFFICWLPenvFISIQLLQGTQEPSESYDESFRhnhpltghIVNLAAFSNSCLNPLIYSFLGETFR 273
7tmA_OR1A-like cd15235
olfactory receptor subfamily 1A and related proteins, member of the class A family of ...
28-158 1.33e-08

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320363 [Multi-domain]  Cd Length: 278  Bit Score: 55.69  E-value: 1.33e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  28 LLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWA--FGRVFCNIWAAV 105
Cdd:cd15235    3 LLFLLFLAMYLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTisYAGCLAQMYFFI 82
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 755547671 106 dVLCCTASIMgLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVIS 158
Cdd:cd15235   83 -AFGNTDSFL-LAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHS 133
7tmA_OR cd13954
olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...
27-159 1.51e-08

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320092 [Multi-domain]  Cd Length: 270  Bit Score: 55.57  E-value: 1.51e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLP-FSAIF-----EILGYWAFGRVFCN 100
Cdd:cd13954    1 ILLFVLFLLIYLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPkMLANLlsgdkTISFSGCLTQLYFF 80
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 755547671 101 IWaavdvLCCTASIMgLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISI 159
Cdd:cd13954   81 FS-----LGGTECFL-LAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSL 133
7tmA_ET_R cd15128
endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
36-337 1.51e-08

endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are 21-amino acid peptides which able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320256 [Multi-domain]  Cd Length: 300  Bit Score: 55.99  E-value: 1.51e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  36 LIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAF-----GRVFCNIWAAVDVLCC 110
Cdd:cd15128   10 IFIVGIIGNSTLLRIIYQNKCMRNGPNALIASLALGDLLYIVIDLPINVYKLLAMDWPFgdqpfGQFLCKLVPFIQKASV 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 111 TASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWR----QQAPEDETICQINEEPGYVL 186
Cdd:cd15128   90 GITVLNLCALSVDRYRAVASWSRIQGIGIPMWTAVEIVMIWMLSAVLAVPEAIGFDmvrfNYKGVTLRTCLLRPETSFMK 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 187 FSA------LGSFY--VPLTIILVMYCRVYVVAKRESRGlksglktdksdSEQVTLRIHRKnvpaegsgvssaknkthfs 258
Cdd:cd15128  170 FYIdvkdwwLFGFYfcLPLVCTAIFYTLMTCEMLRKRNG-----------MLRIALNEHLK------------------- 219
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 259 vrllkfsREKKAAKTLGIVVGCFVLCWLPFFL--VMPIGSFFPNFKPPETVFKIVFWLGY-------LNSCINPIIYPCS 329
Cdd:cd15128  220 -------QRREVAKTVFCLVVIFALCWLPLHLsrILKLTVYDQNDPNRCELLSFLLVLDYfginlatLNSCINPIALYFV 292

                 ....*...
gi 755547671 330 SQEFKKAF 337
Cdd:cd15128  293 SRKFKNCF 300
7tmA_GPR31 cd15199
G protein-coupled receptor 31, member of the class A family of seven-transmembrane G ...
27-337 1.71e-08

G protein-coupled receptor 31, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR31, also known as 12-(S)-HETE receptor, is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid. Phylogenetic analysis showed that GPR31 and oxoeicosanoid receptor 1 (OXER1, GPR170) are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). GPR31, like OXER1, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike the OXER1, does not cause increase in the cytosolic calcium level. GPR31 is also shown to activate NFkB. 12-(S)-HETE is a 12-lipoxygenase metabolite of arachidonic acid produced by mammalian platelets and tumor cells. It promotes tumor cells adhesion to endothelial cells and sub-endothelial matrix, which is a critical step for metastasis.


Pssm-ID: 320327 [Multi-domain]  Cd Length: 278  Bit Score: 55.57  E-value: 1.71e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLtSTVLPFSAIFEILG-YWAFGRVFCNIWAAV 105
Cdd:cd15199    1 IAYASLLILEFGLGLPGNAIALWTFIFRLKVWKPYAVYLLNLVLADVLL-LICLPFKAYFYLNGnRWSLGGGTCKALLFM 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 106 DVLCCTASIMGLCIISIDRYIGVSYP-LRYPTIVTQRRGVRALLcVWALSLVISIGPLFgwrQQAPEDETIC-----QIN 179
Cdd:cd15199   80 LSLSRGVSIAFLTAVALDRYFRVVHPrGKKNSLSLQAAPYISFL-VWLLLVGLTIPTLL---ASQPKNFTECnsfspKDD 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 180 EEPGYVLFSALGSFYVPLTIILVMYCRVYVVAKRESRGLKSGlktdksdsEQVTLRihrknvpaegsgvssaknkthfsv 259
Cdd:cd15199  156 EDFSDTWQEAVFFLQFLLPFGLIVFCTVRIIRRLKKRLRDVG--------KQPKLQ------------------------ 203
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 260 rllkfsrekKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPET------VFKIVFWLGYLNSCINPIIYPCSSQEF 333
Cdd:cd15199  204 ---------RAMALVTSVVVVFGFCFLPCFLARVLMLIFQNKESCNAlniavhTYDVTMCLTYLNSVLDPIVYCFSSPTF 274

                 ....
gi 755547671 334 KKAF 337
Cdd:cd15199  275 RSSY 278
7tmA_NPY5R cd15398
neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G ...
38-157 2.56e-08

neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320520 [Multi-domain]  Cd Length: 273  Bit Score: 54.78  E-value: 2.56e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  38 IFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMGL 117
Cdd:cd15398   12 LLGFLGNLLILTALTKKWKQKTIINFLIGNLAFSDILVVLFCSPFTLTCVLLDQWIFGEVMCHIVPFLQCVSVMVSTLML 91
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 755547671 118 CIISIDRYIGVSYPLRypTIVTQRRGVRALLCVWALSLVI 157
Cdd:cd15398   92 MSIAIVRYHMIKHPLS--NHLTANHGYFLLGTVWTLGFTI 129
7tmA_GPR68_OGR1 cd15367
G protein-coupled receptor 68, member of the class A family of seven-transmembrane G ...
64-223 2.81e-08

G protein-coupled receptor 68, member of the class A family of seven-transmembrane G protein-coupled receptors; The ovarian cancer G-protein receptor 1 (OGR1, also known as GPR68) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), and the G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Knock-out mice studies have suggested that OGR1 plays a role in the regulation of insulin secretion and glucose metabolism. OGR1 couples to G(q/11) proteins and activates phospholipase C and Ca2+ signaling pathways.


Pssm-ID: 320489 [Multi-domain]  Cd Length: 276  Bit Score: 54.77  E-value: 2.81e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  64 YIVNLAVADLLLTSTvLPFSAIFEILG-YWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRR 142
Cdd:cd15367   38 YLCNLTVADLLYIFS-LPFWLQYVLQHdNWTYSELLCKICGILLYENIYISIGFLCCISVDRYLAVVHPFRFHAFRTMKA 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 143 GVRALLCVWALSLVISIgpLFGWRQQAPEDE---TIC-----------QINeepgYVLFSAlgSFYVPLTIILVMYCRVY 208
Cdd:cd15367  117 ATLVSTVIWLKELMTCV--FFFLHGEISKDKenhSVCfehypikawehNIN----YYRFYA--GFLFPIFLLSFSYCRIL 188
                        170
                 ....*....|....*
gi 755547671 209 VVAKReSRGLKSGLK 223
Cdd:cd15367  189 RAVRK-SHGTQKSQK 202
7tmA_SWS1_opsin cd15076
short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G ...
28-207 3.26e-08

short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 1 (SWS1), which mediates visual transduction in response to light at short wavelengths (ultraviolet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320204 [Multi-domain]  Cd Length: 280  Bit Score: 54.82  E-value: 3.26e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  28 LLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTstVLPFSAIF--EILGYWAFGRVFCNIWAAV 105
Cdd:cd15076    2 LQAAFMGFVFIVGTPLNAIVLFVTIKYKKLRQPLNYILVNISLAGFIFC--IFSVFPVFvaSAQGYFFFGRTVCALEAFV 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 106 DVLCCTASIMGLCIISIDRYIGVSYPL---RYptivTQRRGVRALLCVWALSLVISIGPLFGWRQQAPED---------E 173
Cdd:cd15076   80 GSLAGLVTGWSLAFLAFERYIVICKPFgnfRF----GSKHALGAVVATWIIGIGVSLPPFFGWSRYIPEGlqcscgpdwY 155
                        170       180       190
                 ....*....|....*....|....*....|....
gi 755547671 174 TICQINEEPGYVLFSALGSFYVPLTIILVMYCRV 207
Cdd:cd15076  156 TVGTKYRSEYYTWFLFIFCFIVPLSIIIFSYSQL 189
7tmA_OR52P-like cd15953
olfactory receptor subfamily 52P and related proteins, member of the class A family of ...
27-158 3.65e-08

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341354  Cd Length: 275  Bit Score: 54.58  E-value: 3.65e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPfsaifEILGYWAFGrvfcniWAAVD 106
Cdd:cd15953    1 IWISIPFCLMYIVTLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVP-----KALCIFWFN------LKEIT 69
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755547671 107 VLCC--------TASIMG---LCIISIDRYIGVSYPLRYPTIVTQRR--------GVRALLCVWALSLVIS 158
Cdd:cd15953   70 FSGCltqmffihTLSIMEsavLVAMAFDRYVAICNPLRYATILTNSRiaklglvgLIRGVLLILPLPLLLS 140
7tmA_GPR182 cd14988
G protein-coupled receptor 182, member of the class A family of seven-transmembrane G ...
36-159 4.47e-08

G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR182 is an orphan G-protein coupled receptor that belongs to the class A of seven-transmembrane GPCR superfamily. When GPR182 gene was first cloned, it was proposed to encode an adrenomedullin receptor. However when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320119 [Multi-domain]  Cd Length: 278  Bit Score: 54.39  E-value: 4.47e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  36 LIIF--GVLGNILVILsVACHR-HLHSVTHYYIVNLAVADLLLTSTvLPFSAIFEILGY-WAFGRVFCNIWAAVDVLCCT 111
Cdd:cd14988    8 LVIFvvGLVENVLVIW-VNWHRwGSKNLVNLYILNMAIADLGVVLT-LPVWMLEVMLDYtWLWGSFLCKFTHYFYFANMY 85
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 755547671 112 ASIMGLCIISIDRYIGVSYPLRYPTIVTQRRgvRALLC--VWALSLVISI 159
Cdd:cd14988   86 SSIFFLTCLSVDRYLTLTSSSPFWQQHQHRI--RRALCagIWVLSAIIPL 133
7tmA_OR51_52-like cd15917
olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...
29-164 5.93e-08

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341351  Cd Length: 275  Bit Score: 53.83  E-value: 5.93e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  29 LGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLP-FSAIF-----EILGYWAFGRVFCniw 102
Cdd:cd15917    3 LSIPFCAMYLVALLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPkMLGIFwfnarEISFDACLAQMFF--- 79
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 103 aaVDVLCCTASIMGLCiISIDRYIGVSYPLRYPTIVTQRR--------GVRALLCVWALSLVISIGPLFG 164
Cdd:cd15917   80 --IHSFTAMESGVLLA-MAFDRYVAICYPLRYTTILTNTVvgkiglaiLLRAVALIIPLPLLVRRLPYCG 146
7tmA_GPR132_G2A cd15364
proton-sensing G protein-coupled receptor 132, member of the class A family of ...
64-337 6.22e-08

proton-sensing G protein-coupled receptor 132, member of the class A family of seven-transmembrane G protein-coupled receptors; The G2 accumulation receptor (G2A, also known as GPR132) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. G2A was originally identified as a stress-inducible receptor that causes the cell cycle arrest at G2/M phase when serum is deprived. Lysophosphatidylcholine was identified as a ligand for G2A, and whose overexpression was shown to induce cell proliferation, oncogenic transformation, and apoptosis.


Pssm-ID: 320486 [Multi-domain]  Cd Length: 279  Bit Score: 53.63  E-value: 6.22e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  64 YIVNLAVADLLLTSTvLPFSAIFEILGY-WAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRR 142
Cdd:cd15364   38 YLFSLSLCELLYLGT-LPLWTIYVSNNHkWPWGSLACKITGYIFFCNIYISILLLCCISIDRFVAVVYALESRGRRRQRI 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 143 GVRALLCVWALSLVISiGPLFGWRQQAPEDETIC----QINEE-PGYVLFSALGSFYVPLTIILVMYCRVYVVAKrESRG 217
Cdd:cd15364  117 AAFISFLIFIVVGLVH-SPVFIMREGQTEGSHTCfetlQMDTQvAGFYYARFCIGFAIPLAILIFTNYRIFRSIQ-TSTS 194
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 218 LKsglktdksdseqvtlrihrknvpaegsgvssaknkthfsvrllkfSREKKAAKTLGI-VVGCFVLCWLPFFLVMPIG- 295
Cdd:cd15364  195 LT---------------------------------------------PHQKAKVKYLAIaVIVIFLICFAPYHLVLLVRa 229
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 755547671 296 ---SFFPNFKPP-----ETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15364  230 iafSLYPNGMCGfeeriYTPSVIFLCLSTVNSVADPIIYVLVSENVRQDI 279
7tmA_OR2A-like cd15420
olfactory receptor subfamily 2A and related proteins, member of the class A family of ...
27-163 7.70e-08

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320542 [Multi-domain]  Cd Length: 277  Bit Score: 53.49  E-value: 7.70e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNiLVILSVACH-RHLHSVTHYYIVNLAVADLLLTSTVLPfsaifEILGYWAFGR-----VFCN 100
Cdd:cd15420    1 LLLFGLFSLLYIFTLLGN-GLILGLIWLdSRLHTPMYFFLSHLAVVDICYASSTVP-----HMLGNLLKQRktisfAGCG 74
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755547671 101 IWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLF 163
Cdd:cd15420   75 TQMYLFLALAHTECVLLAVMSYDRYVAICHPLRYTVIMNWRVCTTLAATSWACGFLLALVHVV 137
7tmA_ET-CR cd15977
endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled ...
36-337 7.72e-08

endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain. The ET-C receptor is specific for endothelin-3 on frog dermal melanophores; its activation causes dispersion of pigment granules.


Pssm-ID: 320643 [Multi-domain]  Cd Length: 296  Bit Score: 53.76  E-value: 7.72e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  36 LIIFGVLGN---ILVILSVACHRHLHSVthyYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTA 112
Cdd:cd15977   10 IFLVGIIGNstlLRIIYKNKCMRNGPNV---LIASLALGDLLYILIAIPINVIKLIAEDWPFGVHVCKLYPFIQKASVGI 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 113 SIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQA----PEDETICQINEE--PGYVL 186
Cdd:cd15977   87 TVLSLCALSIDRYRAVASWSRIRGIGIPVWKAVEVTLIWAVAIIVAVPEAIAFDMVEidyrGQTLLVCMLPMEqtSSFMR 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 187 FSA------LGSFYVPLTiiLVMYCRVYVVAKRESRGLKSGLKtdksdseqVTLRIHRKnvpaegsgvssaknkthfsvr 260
Cdd:cd15977  167 FYQdvkdwwLFGFYFCLP--LACTGVFYTLMSCEMLSIKNGMR--------IALNDHMK--------------------- 215
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 261 llkfsREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPETVFKIVFWL---------GYLNSCINPIIYPCSSQ 331
Cdd:cd15977  216 -----QRREVAKTVFCLVVIFALCWLPLHLSRILKKTIYDVKDPQRCELLSFLLvmdytginmASLNSCINPVALYFVSR 290

                 ....*.
gi 755547671 332 EFKKAF 337
Cdd:cd15977  291 KFKNCF 296
7tmA_GPR55-like cd15165
G protein-coupled receptor 55 and similar proteins, member of the class A family of ...
38-210 1.01e-07

G protein-coupled receptor 55 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR55 shares closest homology with GPR35, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Lysophosphatidylinositol (LPI) is currently considered as the endogenous ligand for GPR55, although the receptor was initially de-orphanized as a cannabinoid receptor and binds many cannabinoid ligands.


Pssm-ID: 320293 [Multi-domain]  Cd Length: 277  Bit Score: 53.11  E-value: 1.01e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  38 IFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTvLPFSAIFEILgYWAFGRVFCNIWAAVDVLCCTASIMGL 117
Cdd:cd15165   12 VLGLLLNLMALWVFLFKIKKWTESTIYMINLALNDLLLLLS-LPFKMHSSKK-QWPLGRTLCSFLESLYFVNMYGSILII 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 118 CIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIgPLFGWRQQaPEDETIC--QINEE---PGYVLFSALGS 192
Cdd:cd15165   90 VCISVDRYIAIRHPFLAKRLRSPRKAAIVCLTIWVFVWAGSI-PIYSFHDK-PTNNTRCfhGFSNKtwsKKVIVVVEEFG 167
                        170
                 ....*....|....*...
gi 755547671 193 FYVPLTIilVMYCRVYVV 210
Cdd:cd15165  168 FLIPMAV--MVFCSVQII 183
7tmA_OR52I-like cd15950
olfactory receptor subfamily 52I and related proteins, member of the class A family of ...
38-142 1.67e-07

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320616  Cd Length: 275  Bit Score: 52.42  E-value: 1.67e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  38 IFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPfsaifEILGywafgrVFCNIWAAVDVLCC------- 110
Cdd:cd15950   12 VIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVP-----KMLS------IFWLGSAEISFEACftqmffv 80
                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 755547671 111 ---TASIMG-LCIISIDRYIGVSYPLRYPTIVTQRR 142
Cdd:cd15950   81 hsfTAVESGvLLAMAFDRYVAICHPLRYSAILTSQV 116
7tmA_OR2T-like cd15421
olfactory receptor subfamily 2T and related proteins, member of the class A family of ...
36-159 1.80e-07

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320543  Cd Length: 277  Bit Score: 52.55  E-value: 1.80e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  36 LIIF--GVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIfeilGYWAFGRVFCNIWAAVDVLCCTAS 113
Cdd:cd15421    8 LLIFlvALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMAT----NFLSGRKSISFVGCGTQIFFFLTL 83
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 755547671 114 IMGLCII----SIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISI 159
Cdd:cd15421   84 GGAECLLlalmAYDRYVAICHPLRYPVLMSPRVCLLMAAGSWLGGSLNSL 133
7tmA_OR10A-like cd15225
olfactory receptor subfamily 10A and related proteins, member of the class A family of ...
27-160 1.91e-07

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320353  Cd Length: 277  Bit Score: 52.46  E-value: 1.91e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPfsaifeilgywafgRVFCNIWA--- 103
Cdd:cd15225    1 LLLFVVFLLIYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVP--------------KMLVNLLSedk 66
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755547671 104 AVDVLCCTA-----SIMG------LCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIG 160
Cdd:cd15225   67 TISFLGCATqmfffLFLGgtecflLAAMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLG 134
7tmA_P2Y11 cd15376
P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled ...
28-176 2.79e-07

P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y11 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. The activation of P2Y11 is a major pathway of macrophage activation that leads to the release of cytokines. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320498 [Multi-domain]  Cd Length: 284  Bit Score: 52.01  E-value: 2.79e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  28 LLGVILGGLIIFGVLGNILVILSVAC--HRHLHSVThYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAV 105
Cdd:cd15376    2 FLWPILGVEFLVAVLGNGLALWLFVTreRRPWHTGV-VFSFNLAVSDLLYALSLPLLAAYYYPPKNWRFGEAACKLERFL 80
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755547671 106 DVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISiGPLFGWR--QQAPEDETIC 176
Cdd:cd15376   81 FTCNLYGSIFFITCISLNRYLGIVHPFFTRSHVRPKHAKLVSLAVWLLVAALS-APVLSFShlEVERHNKTEC 152
7tmA_PAR3 cd15371
protease-activated receptor 3, member of the class A family of seven-transmembrane G ...
37-204 3.59e-07

protease-activated receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320493  Cd Length: 274  Bit Score: 51.34  E-value: 3.59e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  37 IIFGVLGNIlVILSVACHRHLHSVTHYYIVNLAVADLLLTSTvLPFSAIFEILGY-WAFGRVFCNIWAAVDVLCCTASIM 115
Cdd:cd15371   11 VVLGVPSNA-IILWMLFFRLRSVCTAIFYANLAISDLLFCIT-LPFKIVYHLNGNnWVFGETMCRIITITFYGNMYCSIL 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 116 GLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIgPLFGWRQQ---APEDETIC---QINEEPG------ 183
Cdd:cd15371   89 LLTCISINRYLAIVHPFIYRSLPKKTYAVLICALVWTIVFLYML-PFFILKQTyylKELNITTChdvLPECEQNsnfqfy 167
                        170       180
                 ....*....|....*....|.
gi 755547671 184 YVLFSALGSFYVPLTIILVMY 204
Cdd:cd15371  168 YFISMAVFGFLIPLVITIFCY 188
7tmA_OR52B-like cd15221
olfactory receptor subfamily 52B and related proteins, member of the class A family of ...
38-141 3.86e-07

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320349  Cd Length: 275  Bit Score: 51.52  E-value: 3.86e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  38 IFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFS-AIF-----EILGYWAFGRVFCniwaaVDVLCCT 111
Cdd:cd15221   12 IVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMlAIFwfgagEISFDGCLTQMFF-----VHFVFVT 86
                         90       100       110
                 ....*....|....*....|....*....|
gi 755547671 112 ASIMgLCIISIDRYIGVSYPLRYPTIVTQR 141
Cdd:cd15221   87 ESAI-LLAMAFDRYVAICYPLRYTTILTHS 115
7tmA_OR4D-like cd15936
olfactory receptor 4D and related proteins, member of the class A family of ...
41-159 4.17e-07

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320602 [Multi-domain]  Cd Length: 267  Bit Score: 51.18  E-value: 4.17e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  41 VLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLP------FSAIFEILGYWAFGRVFCNIWAAvdvlccTASI 114
Cdd:cd15936   15 WLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPkmlsdlLSQTKTISFNGCMAQMFFFHFTG------GAEV 88
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 755547671 115 MGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISI 159
Cdd:cd15936   89 FLLSVMAYDRYIAIHKPLHYLTIMNQGVCTGLVAGSWLGGFAHSI 133
7tmA_GPR174-like cd15152
putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G ...
26-335 4.95e-07

putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR174 has been recently identified as a lysophosphatidylserine receptor that enhances intracellular cAMP formation by coupling to a G(s) protein. GPR174 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320280 [Multi-domain]  Cd Length: 282  Bit Score: 51.26  E-value: 4.95e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  26 AILLGVILggliIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTvLPFSAIFEILGYWAFGRVFCNIWAAV 105
Cdd:cd15152    4 AVTYTVIL----IPGLIGNVLALWVFYAYVKETKRAVIFMINLAIADLLQVLS-LPLRIFYYLNKSWPFGKFLCMFCFYL 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 106 DVLCCTASIMGLCIISIDRYIGVSYPLRYPTIvTQRRGVRALLCVWalsLVISIG----PLFgwRQQAPEDETIC----- 176
Cdd:cd15152   79 KYVNMYASIYFLVCISVRRCLYLIYPFRYNDC-KRKCDVYISIAGW---LVVCVGclpfPLL--RQSQDTNPTCCfadlp 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 177 --QINEEPGYVLFS--ALGSFYVPLTIILvmYCrvyvvakresrglksglktdksdSEQVTLRIHRKNVPAEGSGvssak 252
Cdd:cd15152  153 lrNVGLTTSVIMLTiaELTGFVTPLLIVL--YC-----------------------SWKTVMSLREKTPVLQDLG----- 202
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 253 nkthfsvrllkfsREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPETVFK--------IVFWLGYLNSCINPI 324
Cdd:cd15152  203 -------------EKKKALKMILTCAVVFLICFAPYHISFPLDFLVKSNKIKSCTARkvilifhpVALCLASLNSCLDPV 269
                        330
                 ....*....|.
gi 755547671 325 IYPCSSQEFKK 335
Cdd:cd15152  270 IYYFTTDEFKR 280
7tmA_TXA2_R cd15143
thromboxane A2 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
102-216 8.10e-07

thromboxane A2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The thromboxane receptor, also known as the prostanoid TP receptor, is a class A G-protein coupled receptor whose endogenous ligand is thromboxane A2 (TXA2). TXA2 is the major product of cyclooxygenase metabolite of arachidonic acid that found predominantly in platelets and stimulates platelet aggregation, Ca2+ influx into platelets, and also causes vasoconstriction. TXA2 has been shown to be involved in immune regulation, angiogenesis and metastasis, among many others. Activation of TXA2 receptor is coupled to G(q) and G(13), resulting in the activations of phospholipase C and RhoGEF, respectively. TXA2 receptor is widely distributed in the body and is abundantly expressed in thymus and spleen.


Pssm-ID: 320271 [Multi-domain]  Cd Length: 296  Bit Score: 50.59  E-value: 8.10e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 102 WAAVDVLCCTASIMGLCII-------------SIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFG---W 165
Cdd:cd15143   72 WRVVDPDCYLCNFMGLSMVfyglcplllgatmAVERFFGINRPFSRSTAMSKRRAWYMVGMVWAFAFLLGLLPILGlgrY 151
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 166 RQQAPEDETICQINEEPGYV----LFSALGSFYVPLTIIL-----VMYCRVYvvAKRESR 216
Cdd:cd15143  152 TLQYPGSWCFLTLLFDSKDVafglLFSFLGILSVGLSFLLntvsvVTLCRVY--HDRESV 209
7tmA_GPR176 cd15006
orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; ...
36-163 8.15e-07

orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; GPR176 is a putative G protein-coupled receptor that belongs to the class A GPCR superfamily; no endogenous ligand for GPR176 has yet been identified. The class A rhodopsin-like GPCRs represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320135  Cd Length: 289  Bit Score: 50.64  E-value: 8.15e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  36 LIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEI---LGYWAFGRVFCNIWAAVDVLCCTA 112
Cdd:cd15006    9 IFVGSLLGNFMVLWSTCRTSVFKSVTNRFIKNLACSGICASLVCVPFDIVLSAsphCCWWIYTLLFCKVIKFLHKVFCSV 88
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 755547671 113 SIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVraLLCVWALSLVISIgPLF 163
Cdd:cd15006   89 TVLSFAAIALDRYYSVLYPLERKISDAKSRDL--VIYIWAHAVVASV-PVF 136
7tmA_OR4-like cd15226
olfactory receptor family 4 and related proteins, member of the class A family of ...
27-159 8.87e-07

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320354 [Multi-domain]  Cd Length: 267  Bit Score: 50.28  E-value: 8.87e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPfsaifeilgywafgRVFCNIWAAVD 106
Cdd:cd15226    1 LFLFVFFSLFYVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATP--------------KMICDLLREHK 66
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755547671 107 VL----CCT----------ASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISI 159
Cdd:cd15226   67 TIsfggCMAqifflhffggSEMVLLIAMAFDRYVAICKPLHYLTIMSPRMCILLVVASWIIGFIHSL 133
7tmA_GPR185-like cd15960
G protein-coupled receptor 185 and similar proteins, member of the class A family of ...
44-337 8.90e-07

G protein-coupled receptor 185 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR185, also called GPRx, is a member of the constitutively active GPR3/6/12 subfamily of G protein-coupled receptors. It plays a role in the maintenance of meiotic arrest in Xenopus laevis oocytes through G(s) protein, which leads to increased cAMP levels. In Xenopus laevis, GPR185 is primarily expressed in brain, ovary, and testis; however, its ortholog has not been identified in other vertebrate genomes. GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest.


Pssm-ID: 320626 [Multi-domain]  Cd Length: 268  Bit Score: 50.28  E-value: 8.90e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  44 NILVILSVACHRHLHSVTHYYIVNLAVADLLL-TSTVLPFSAIFeilgywAFGRVFCNIWAAVDVLCC-TASIMGLCIIS 121
Cdd:cd15960   18 NAIVIAILFYTPSLRAPMFILIGSLALADLLAgLGLIANFVAIY------VMNSEAVTLCSAGLLLAAfSASVCSLLAIT 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 122 IDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWR-QQAPEDETICQINEEPGYVLFSAlgSFYVPLTII 200
Cdd:cd15960   92 VDRYLSLYNALTYHTERTLTFTYGLLALLWLTCIGIGLLPAMGWNcLRAPASCSVLRPVTKNNAAVLAV--SFLLLFALM 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 201 LVMYCRVYVVAKREsrglksglktdksdSEQVTLRihrknvpaegsgvssaknktHFSVRLLKFSREKKAAKTLGIVVGC 280
Cdd:cd15960  170 MQLYLQICRIAFRH--------------AQQIAVQ--------------------HQFVNFCLASSTRKGVSTLSLILAT 215
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 755547671 281 FVLCWLPFFL-VMPIGSFFPNFKPPETVFKIVfwlgyLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15960  216 FAFCWVPFAVySMVADSSYPMIYTYYLVLPAA-----CNSVINPIIYAFRNPDIQKSL 268
7tmA_OR5AK3-like cd15408
olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...
25-141 9.54e-07

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320530  Cd Length: 287  Bit Score: 50.40  E-value: 9.54e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  25 KAILLGVILGgLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLP-----FSAIFEILGYwafgrVFC 99
Cdd:cd15408   13 QVLLFVVFLL-IYVITLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPktllnLLAERKVISF-----TGC 86
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 755547671 100 NIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQR 141
Cdd:cd15408   87 LTQLYFYAVFATTECYLLAAMAYDRYVAICNPLLYTVIMSQR 128
7tmA_OR2F-like cd15429
olfactory receptor subfamily 2F and related proteins, member of the class A family of ...
29-151 1.06e-06

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320546 [Multi-domain]  Cd Length: 277  Bit Score: 50.09  E-value: 1.06e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  29 LGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPfsaifEILGYwafgrvFCNIWAAVDVL 108
Cdd:cd15429    3 LFVLFLVMYLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVP-----QMLAH------FLAEHKTISFA 71
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 755547671 109 CCTASI-----MG------LCIISIDRYIGVSYPLRYPTIVTQRrgvralLCVW 151
Cdd:cd15429   72 SCVAQLfislaLGgtefilLAVMAYDRYVAVCHPLRYTVIMSGG------LCIQ 119
7tmA_FFAR cd14983
free fatty acid receptors, member of the class A family of seven-transmembrane G ...
37-156 1.22e-06

free fatty acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the free fatty acid receptors (FFARs) which bind free fatty acids (FFAs). They belong to the class A G-protein coupled receptors and are composed of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR1 is a receptor for medium- and long-chain FFAs, whereas FFAR2 and FFAR3 are receptors for short chain FFAs (SCFAs), which have different ligand affinities. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and also indirectly increases insulin secretion by enhancing the release of incretin. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to the inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320114 [Multi-domain]  Cd Length: 278  Bit Score: 49.74  E-value: 1.22e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  37 IIFGVLGNILVI-LSVACHRHLHSVTHYYIVNLAVADLLLTsTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIM 115
Cdd:cd14983   11 ILLGLPSNLLALyAFVNRARLRLTPNVIYMINLCLSDLVFI-LSLPIKIVEALSSAWTLPAVLCPLYNLAHFSTLYASTC 89
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 755547671 116 GLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLV 156
Cdd:cd14983   90 FLTAISAGRYLGVAFPIKYQLYKKPLYSCLVCVAIWALVIF 130
7tmA_OR6B-like cd15224
olfactory receptor subfamily 6B and related proteins, member of the class A family of ...
27-163 1.40e-06

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320352  Cd Length: 270  Bit Score: 49.59  E-value: 1.40e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSaifeILGYWA------FGRVFCN 100
Cdd:cd15224    1 LLLFLLFLIAYVLTLLENLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKL----LAGFLSqnksisFVGCMTQ 76
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755547671 101 IWAAVdVLCCTASIMgLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLF 163
Cdd:cd15224   77 LYFFL-SLACTECVL-LAVMAYDRYVAICHPLRYPVIMTHQLCVQLAAGSWLSGFLISMIKVY 137
7tmA_PGI2 cd15141
prostaglandin I2 receptor, member of the class A family of seven-transmembrane G ...
36-211 1.74e-06

prostaglandin I2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin I2 receptor (also called prostacyclin receptor or prostanoid IP receptor) is a class A, G protein-coupled receptor whose endogenous ligand is prostacyclin, which is the major product of cyclooxygenase metabolite of arachidonic acid that found predominantly in platelets and vascular smooth muscle cells (VSMCs). The PGI2 receptor is coupled to both G(s) and G(q) protein subtypes, resulting in increased cAMP formation, phosphoinositide turnover, and Ca2+ signaling. PGI2 receptor activation by prostacyclin induces VSMC differentiation and produces a potent vasodilation and inhibition of platelet aggregation.


Pssm-ID: 320269 [Multi-domain]  Cd Length: 301  Bit Score: 49.43  E-value: 1.74e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  36 LIIFGVLGNILVILSVACHRH----LHSVTHYYIVNLAVADLLLTSTVLPfsAIF-------EILGYwAFGRVFCNIWAA 104
Cdd:cd15141   10 MFAAGVVGNLLALGILGVHRKerrtKSSAFCVLVTGLAATDLLGTCFLSP--MVFvsyaqnsSLLGL-AAGQPLCHLFAF 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 105 VDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGW---RQQAPedETICQI--- 178
Cdd:cd15141   87 AMTFFGLASMLILFAMAVERCLAISHPYFYAQHSGRRLAKLALPAIYAFGALFCALPLLGVgrhKQYCP--GTWCFIrmt 164
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 755547671 179 ---NEEPGYVLFSALGSFYVPLTIILVMYCRVYVVA 211
Cdd:cd15141  165 vpgHREPGSLAFSLLYASLMALLIAAIFLCNGSVTV 200
7tmA_OR5V1-like cd15231
olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...
27-159 2.62e-06

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320359 [Multi-domain]  Cd Length: 277  Bit Score: 48.80  E-value: 2.62e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVD 106
Cdd:cd15231    1 LLLFLIFLIIYLVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFF 80
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 755547671 107 VLCCTASIMGLCIISIDRYIGVSYPLRYPTIVtqRRGVRALLCV--WALSLVISI 159
Cdd:cd15231   81 VSFVGTECLLLAVMAYDRYVAICNPLHYAVIM--SRKVCLQLAAasWLCGFLNSA 133
7tmA_MrgprB cd15107
mas-related G protein-coupled receptor subtype B, member of the class A family of ...
27-326 3.26e-06

mas-related G protein-coupled receptor subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320235  Cd Length: 276  Bit Score: 48.55  E-value: 3.26e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGgliIFGVLGNILVI--LSVACHRHLHSVthyYIVNLAVADLLLTSTVLPFSaiFEILgyWAFGRVFCNIWAA 104
Cdd:cd15107    4 NFLSIIIA---LVGLAGNAIVLwlLGFHMHRNAFSV---YILNLAGADFLFLCTQIVFS--LEIV--LQFHSIDIHIPLF 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 105 VDVLCCTASIMGLCI---ISIDRYIGVSYPLRYPtivTQR-RGVRALLCV--WALSLVISIgplfgwrqqapedeticqI 178
Cdd:cd15107   74 LLTVTMFAYLAGLSMitaISIERCLSVMWPIWYH---CQRpRHTSAVICTllWVLSLLLSL------------------L 132
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 179 NEEPGYVLFSALG-SFYVPLTIILVMYCRV-YVVAKRESRGLksglktdksdseqvTLRI----HRKNVpaegsgvssak 252
Cdd:cd15107  133 EGKGCGFLFSTYDyYWCWTLDLITTAWLIVlFVVLSGSSLAL--------------LVRIfcgsHRIPV----------- 187
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755547671 253 nkTHFSVrllkfsrekkaakTLGIVVGCFVLCWLPF----FLVMPIGSFFpnFKPPETVFKIVFWLGYLNSCINPIIY 326
Cdd:cd15107  188 --TRLYV-------------TIALTVLVFLIFGLPFgiywFLLKWIEEFY--IVPCCGFYEVILFLSCVNSCANPIIY 248
7tmA_OR12D-like cd15915
olfactory receptor subfamily 12D and related proteins, member of the class A family of ...
27-159 4.38e-06

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320581 [Multi-domain]  Cd Length: 271  Bit Score: 48.07  E-value: 4.38e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGgLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPfsaifEILGYWAFGRvfcniwAAVD 106
Cdd:cd15915    2 FLFVLFLL-LYLASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVP-----KMLAGLLSEH------KTIS 69
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755547671 107 VLCCTASI-----------MGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISI 159
Cdd:cd15915   70 FQGCISQLhffhflgsseaMLLAVMAYDRYVAICNPLRYTVIMNPQVCLLLAVACWVTGFFHAL 133
7tmA_OR2-like cd15237
olfactory receptor family 2 and related proteins, member of the class A family of ...
41-159 4.96e-06

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320365 [Multi-domain]  Cd Length: 270  Bit Score: 48.04  E-value: 4.96e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  41 VLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMGLCII 120
Cdd:cd15237   15 LLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFFLALGVTECVLLAVM 94
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 755547671 121 SIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISI 159
Cdd:cd15237   95 AYDRYVAICNPLRYSVIMSRRVCVRLAATSWASGFLNSL 133
7tmA_P2Y6 cd15379
P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled ...
27-227 7.69e-06

P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes mammalian P2Y6, avian P2Y3, and similar proteins. P2Y3 is the avian homolog of mammalian P2Y6. They belong to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320501 [Multi-domain]  Cd Length: 288  Bit Score: 47.56  E-value: 7.69e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVD 106
Cdd:cd15379    1 VLLPLVYSVVFLLGLPLNAVVIGQIWATRQALSRTTIYMLNLATADLLYVCSLPLLIYNYTQKDYWPFGDFTCRLVRFQF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASIMGLCIISIDRYIGVSYPLrypTIVTQRRGVRA--LLCVWALSLVISI-GPLFGWRQQAPE-DETICQINEEP 182
Cdd:cd15379   81 YTNLHGSILFLTCISVQRYLGICHPL---ASWHKKKGKKLtwLVCGAVWLVVIAQcLPTFVFASTGTQrNRTVCYDLSPP 157
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 755547671 183 G-------YVLFSALGSFYVPLTIILVMYCRVYVVAKRE----SRGLKSGLKTDKS 227
Cdd:cd15379  158 ArstayfpYGITLTRTGFLLPFAARLACYCSMATILCRVviavAVVAAPGEKRGKA 213
7tmA_SREB1_GPR27 cd15216
super conserved receptor expressed in brain 1 (or GPR27), member of the class A family of ...
36-337 7.71e-06

super conserved receptor expressed in brain 1 (or GPR27), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320344 [Multi-domain]  Cd Length: 332  Bit Score: 47.71  E-value: 7.71e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  36 LIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAF----GRVFCNIWAAVDVLCCT 111
Cdd:cd15216   10 LLCVSLAGNVLFALLIVRERSLHRAPYYLLLDLCLADGLRALACLPAVMLAARRAAAAAgtppGALGCKLLAFLAALFCF 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 112 ASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLC-VWALSLVISIGPLFGWRQQAPEDETiCQINEE----PGYVL 186
Cdd:cd15216   90 HAAFLLLGVGVTRYLAIAHHRFYAERLAGWPCAAMLVCaAWALALAAAFPPVLDGGGADDEDAP-CALEQRpdgaPGALG 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 187 FSALGSFYVPLTIILVMYCRVYVVAKRESRGLK-----------SGLKTDKSDSEQVTLRIHRKNVPAEGSGVSSAkNKT 255
Cdd:cd15216  169 FLLLLAAVVGATHLVYLRLLFFIHDRRKMRPARlvpavshdwtfHGPGATGQAAANWTAGFGRGPTPPALVGIRPA-GPG 247
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 256 HFSVRLL---KFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIYPCSSQE 332
Cdd:cd15216  248 RGARRLLvleEFKTEKRLCKMFYAITLLFLLLWGPYVVASYLRVLVRPGAVPQAYLTASVWLTFAQAGINPVVCFLFNRE 327

                 ....*
gi 755547671 333 FKKAF 337
Cdd:cd15216  328 LRDCF 332
7tmA_OR51-like cd15222
olfactory receptor family 51 and related proteins, member of the class A family of ...
41-142 7.91e-06

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320350  Cd Length: 275  Bit Score: 47.50  E-value: 7.91e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  41 VLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPfsaifEILGywafgrVFCNIWAAVDVLCC--------TA 112
Cdd:cd15222   15 LLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLP-----TVLG------IFWFNAREISFDAClaqmffihTF 83
                         90       100       110
                 ....*....|....*....|....*....|...
gi 755547671 113 SIMG---LCIISIDRYIGVSYPLRYPTIVTQRR 142
Cdd:cd15222   84 SFMEssvLLAMAFDRFVAICNPLRYASILTNSR 116
7tmA_OR2B-like cd15947
olfactory receptor subfamily 2B and related proteins, member of the class A family of ...
27-160 9.08e-06

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320613 [Multi-domain]  Cd Length: 270  Bit Score: 47.23  E-value: 9.08e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGgLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLP-----FSAIFEILGYWAfgrvfCNI 101
Cdd:cd15947    2 PLFVVVLI-FYLLTLLGNTAIILLSLLDPRLHTPMYFFLSNLSFLDLCFTTSIVPqmlvnLWGPDKTISYGG-----CVT 75
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 102 WAAVDV-LCCTASIMgLCIISIDRYIGVSYPLRYPTIVTQRrgvralLCVWALSLVISIG 160
Cdd:cd15947   76 QLYIFLwLGSTECVL-LAVMAFDRYVAVCRPLHYTVIMHPR------LCVQLAALSWLSG 128
7tmA_GPR82 cd14996
orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G ...
27-125 1.17e-05

orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 82 of unknown function. GPR82 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320127 [Multi-domain]  Cd Length: 305  Bit Score: 47.10  E-value: 1.17e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTvLPFSAIFEILG-YWAFGRVFCNIWAAV 105
Cdd:cd14996    1 VALPIIYSFLFVTGVFGNLLSLWVFLTKISKKTSTHIYLINLVTANLLVCSA-MPFQAAYFLKGfYWKYQSTQCRIANFF 79
                         90       100
                 ....*....|....*....|....
gi 755547671 106 DVLCCTAS----IMGLCIISIDRY 125
Cdd:cd14996   80 GTLVIHVSmcvsILILSWIAISRY 103
7tmA_ETBR-LP2 cd15126
endothelin B receptor-like protein 2, member of the class A family of seven-transmembrane G ...
30-166 1.21e-05

endothelin B receptor-like protein 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelin B receptor-like protein 2, also called GPR37L1, is almost exclusively expressed in the nervous system. It has recently been shown to act as a receptor for the neuropeptide prosaptide, the active fragment of the secreted neuroprotective and glioprotective factor prosaposin (also called sulfated glycoprotein-1). Both prosaptide and prosaposin protect primary astrocytes against oxidative stress. GPR37L1 is part of the class A family of GPCRs that includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320254  Cd Length: 298  Bit Score: 46.78  E-value: 1.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  30 GVILGGLIIF--GVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDV 107
Cdd:cd15126    2 GILLLALVVFavGIVGNLSVMCIVWHSYYLKSAWNSILASLALWDFLVLFFCLPVVVFNEITKKRLLGDVSCRVVPYMEV 81
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 108 LCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCV-WALSLVISIGPLFGWR 166
Cdd:cd15126   82 TSLGVTTFSLCALGIDRFHAATSPQPKARPVERCQSILAKLAViWVGSMTLAVPELLLWQ 141
7tmA_OR2W-like cd15434
olfactory receptor subfamily 2W and related proteins, member of the class A family of ...
27-160 1.30e-05

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320551 [Multi-domain]  Cd Length: 277  Bit Score: 46.60  E-value: 1.30e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGgLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPfSAIFEILGY-WAFGRVFCNIWAAV 105
Cdd:cd15434    2 ILSVVVLI-FYLLTLVGNTTIILVSCLDSRLHTPMYFFLANLSFLDLCFTTSIIP-QMLVNLWGPdKTISYVGCAIQLFI 79
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 755547671 106 DVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRrgvralLCVWALSLVISIG 160
Cdd:cd15434   80 ALGLGGTECVLLAVMAYDRYAAVCQPLHYTVVMHPR------LCWKLVAMSWLIG 128
7TM_GPCR_Srsx pfam10320
Serpentine type 7TM GPCR chemoreceptor Srsx; Chemoreception is mediated in Caenorhabditis ...
37-141 1.37e-05

Serpentine type 7TM GPCR chemoreceptor Srsx; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srsx is a solo family amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 255903 [Multi-domain]  Cd Length: 257  Bit Score: 46.43  E-value: 1.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671   37 IIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFeiLGYWAFGRVFCNIWAAVDVLCCTASIMG 116
Cdd:pfam10320   1 SVIGLFGNVLMIHLTFRKKKLRSKCSILICVQCIAHLICLCGEIVFVVLL--FTGTQLTRNECFWMISFYIFGQTAQGPL 78
                          90       100
                  ....*....|....*....|....*
gi 755547671  117 LCIISIDRYIGVSYPLRYPTIVTQR 141
Cdd:pfam10320  79 MLMIGIDRLIAVKFPIFYRLLSSSK 103
7tmA_ET-AR cd15975
endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G ...
36-337 1.44e-05

endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320641 [Multi-domain]  Cd Length: 300  Bit Score: 46.78  E-value: 1.44e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  36 LIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAF-----GRVFCNIWAAVDVLCC 110
Cdd:cd15975   10 IFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYIVIDIPINVYKLLAQKWPFddssfGVFLCKLVPFLQKASV 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 111 TASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWR----QQAPEDETICQINEEPGYVL 186
Cdd:cd15975   90 GITVLNLCALSVDRYRAVASWSRVQGIGIPLITAIEIFSIWVLSFILAIPEAIGFVmvpfEYNGEQYRTCMLNATTKFMN 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 187 FSA------LGSFY--VPLTIILVMYCRVYVVAKRESRGlksglktdksdSEQVTLRIHrknvpaegsgvssaknkthfs 258
Cdd:cd15975  170 FYVdakdwwLFGFYfcVPLACTAIFYTLMTCEMLNRRKG-----------SLRIALSEH--------------------- 217
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 259 vrlLKFSREkkAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPETVFKIVFW---------LGYLNSCINPIIYPCS 329
Cdd:cd15975  218 ---LKQRRE--VAKTVFCLVVIFALCWFPLHLSRILKKTVYNENDPRRCELLSFLlvmdyisinLATMNSCINPIALYFV 292

                 ....*...
gi 755547671 330 SQEFKKAF 337
Cdd:cd15975  293 SKKFKNCF 300
7tmA_OR4E-like cd15940
olfactory receptor 4E and related proteins, member of the class A family of ...
43-163 2.10e-05

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320606 [Multi-domain]  Cd Length: 267  Bit Score: 45.90  E-value: 2.10e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  43 GNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLP--FSAIFEILGYWAFGRvfCNIWAAVDVLCCTASIMGLCII 120
Cdd:cd15940   17 GNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPkmLSDLLSEEKTISFNG--CVTQLFFLHLFACTEIFLLTIM 94
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 755547671 121 SIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLF 163
Cdd:cd15940   95 AYDRYVAICNPLHYPTVMNHKVCLWLVAALWLGGTVHSLAQTF 137
7tmA_OR8H-like cd15411
olfactory receptor subfamily 8H and related proteins, member of the class A family of ...
38-160 2.19e-05

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320533 [Multi-domain]  Cd Length: 279  Bit Score: 46.16  E-value: 2.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  38 IFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMGL 117
Cdd:cd15411   12 VITVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFFIALATTECFLL 91
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 755547671 118 CIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIG 160
Cdd:cd15411   92 GLMAYDRYVAICNPLLYTVVMSRRVCLKLAAGSYAAGFLNSLI 134
7tmA_OR5P-like cd15416
olfactory receptor subfamily 5P and related proteins, member of the class A family of ...
26-151 2.27e-05

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320538 [Multi-domain]  Cd Length: 279  Bit Score: 45.82  E-value: 2.27e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  26 AILLGVILGgLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLP-----FSAIFEILGYWAFGRVFCN 100
Cdd:cd15416    1 IILFVLFLV-IYSVTLLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPkmlvnFLVEKTTISYPGCAAQLCS 79
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 755547671 101 IWAAVDVLCCTASIMglciiSIDRYIGVSYPLRYPTIVTQRrgvralLCVW 151
Cdd:cd15416   80 AATFGTVECFLLAAM-----AYDRYVAICNPLLYSTIMSQK------VCVL 119
7tmA_P2Y-like cd15922
P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G ...
67-337 2.39e-05

P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y-like proteins are an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320588 [Multi-domain]  Cd Length: 284  Bit Score: 45.86  E-value: 2.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  67 NLAVADLLLTStVLPFSAIFEILG-YWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVsypLRYPTIVT-QRRGV 144
Cdd:cd15922   41 NLALSDAIITP-AAPLLIAYFSLGsHWPFGQFLCQLKVFLLSTHMYGSIYFLMLISIHRYVTV---VHYNWKSLwKKKSF 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 145 RALLC--VWALSLVISIgPLFGWRQQAPEDE-----TICQINEEPGYVLFS---ALGSFYVPLTIILVMYCRV-YVVAKR 213
Cdd:cd15922  117 MKKLClgVWLLLFVQGL-PFFFVLKTSVIDGktkclSIHQSELSLLYFVWNfvlLILGFLLPFGVSLTCYALLgASIAKM 195
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 214 ESRGLKSglKTDKSDSEQvtlrihrknvpaegsgvssaknkthfsvrllkfsrekkaakTLGIVVGCFVLCWLPFFLVMP 293
Cdd:cd15922  196 NSNNARG--RAMKAKSLQ-----------------------------------------MIGISLVIFIICFVPLHVTRT 232
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 755547671 294 IGSFFPNFKPP--------ETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15922  233 VGVVVKLFYPEsctllhkvEVAYYISWVLTGVNCCLDPLLYCFASEKFRKSF 284
7tmA_FFAR2_FFAR3 cd15170
free fatty acid receptors 2, 3, and similar proteins, member of the class A family of ...
67-337 2.97e-05

free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes free fatty acid receptor 2 (FFAR2), FFAR3, and similar proteins. They are a member of the class A G-protein coupled receptors that bind free fatty acids. The FFAR subfamily is composed of three receptors, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR2 and FFAR3 are cell-surface receptors for short chain FFAs (SCFAs) with different ligand affinities, whereas FFAR1 is a receptor for medium- and long-chain FFAs. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), thus suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320298  Cd Length: 278  Bit Score: 45.71  E-value: 2.97e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  67 NLAVADLLLTStVLPFSAIFEILGY-WAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVR 145
Cdd:cd15170   42 NLTVSDLIFLL-FLPFKMAEAASGMiWPLPYFLCPLSSFIFFSTIYISTLFLTAISVERYLGVAFPIKYKLRRRPLYAVI 120
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 146 ALLCVWAL-----SLVISIGPLFGWRQQAPEDETICQIN---EEPGYVLFSALGSFYVPLTIILVMYCRVYVvakresrg 217
Cdd:cd15170  121 ASVFFWVLafshcSIVYIVEYHIDSENTSVTNNSRCYDNftpEQLKILLPVRLELFLVLFCIPFLITCFCYI-------- 192
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 218 lksglktdksdseqvtlrihrknvpaegsgvssakNKTHFSVRLLKFSREKKaAKTLGIVVGC---FVLCWLPFFLVMPI 294
Cdd:cd15170  193 -----------------------------------NFIRILSSLPHISRQRK-QRAIGLAVATllnFIVCFAPYNISHVV 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 755547671 295 GsfFPNFKPPETVFKiVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Cdd:cd15170  237 G--FIQRKSPEWRMY-ALLLSTLNACLDPIIFYFSSSAVRRAF 276
7tmA_P2Y12-like cd15924
P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of ...
64-326 3.30e-05

P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y12-like receptors as well as closely related orphan receptor, GPR87.


Pssm-ID: 341352 [Multi-domain]  Cd Length: 284  Bit Score: 45.52  E-value: 3.30e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  64 YIVNLAVADLLLTSTvLPFSAIFEI-LGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRyPTIVTQRR 142
Cdd:cd15924   37 YLKNTVVADLLMILT-FPFKILSDAgLGPWQLRTFVCRVTSVLFYFTMYTSIVFLGLISIDRYLKIVRPFK-TSFPKSVS 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 143 GVRAL-LCVWALSLVISIgPLFGWRQQAPEDETICQINEEPG--------YVLFSALGSFYVPLTIILVMYCrvyvvakr 213
Cdd:cd15924  115 FAKILsVVVWALMFLLSL-PNMILTNQQPREKNVKKCSFLKSelglkwheIVNYICQVIFWIVFLLMIVCYT-------- 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 214 esrglksglktdksdseQVTLRIHRKNVPAEGSGvSSAKNKTHFSVRllkfsrekkaaktlgIVVGCFVLCWLPFFLV-M 292
Cdd:cd15924  186 -----------------AITKKVYRSYRRVFRSS-SSRRKKSNVKIF---------------IIVAVFFVCFVPYHFArI 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 755547671 293 PIGSFFPNFKPPETVFKIVF-------WLGYLNSCINPIIY 326
Cdd:cd15924  233 PYTLSQTRDVFDCTAENILFyvkeatlFLSALNVCLDPIIY 273
7tmA_OR5C1-like cd15945
olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...
38-141 4.31e-05

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320611  Cd Length: 292  Bit Score: 45.12  E-value: 4.31e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  38 IFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLP-----FSAIFEILGYWAFGRVFCNIWAAVDVLCCTA 112
Cdd:cd15945   25 LLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPkmlvdLLAKRKSIPFYGCALQMFFFAAFADAECLLL 104
                         90       100
                 ....*....|....*....|....*....
gi 755547671 113 SIMglciiSIDRYIGVSYPLRYPTIVTQR 141
Cdd:cd15945  105 AVM-----AYDRYVAICNPLLYTTAMSRR 128
7tmA_OR4A-like cd15939
olfactory receptor 4A and related proteins, member of the class A family of ...
41-163 5.05e-05

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320605 [Multi-domain]  Cd Length: 267  Bit Score: 44.90  E-value: 5.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  41 VLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLP-----FSAIFEILGYWAfgrvfCNIWAAVDVLCCTASIM 115
Cdd:cd15939   15 VLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPklivdLLSERKTISFNG-----CMTQLFAEHFFGGAEIF 89
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 755547671 116 GLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLF 163
Cdd:cd15939   90 LLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQIL 137
7tmA_GPR37 cd15127
G protein-coupled receptor 37, member of the class A family of seven-transmembrane G ...
31-172 5.90e-05

G protein-coupled receptor 37, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR37, also called parkin-associated endothelin-like receptor (Pael-R), was isolated from a set of human brain frontal lobe expressed sequence tags. It is highly expressed in the mammalian CNS. It is a substrate of parkin and is involved in the pathogenesis of Parkinson's disease. GPR37 has recently been shown to act as a receptor for the neuropeptide prosaptide, the active fragment of the secreted neuroprotective and glioprotective factor prosaposin (also called sulfated glycoprotein-1). Both prosaptide and prosaposin protect primary astrocytes against oxidative stress. GPR37 is part of the class A family of GPCRs that includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320255 [Multi-domain]  Cd Length: 298  Bit Score: 44.85  E-value: 5.90e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  31 VILGGLIIF--GVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVL 108
Cdd:cd15127    3 VMCLSVVIFgiGIMGNVAVMCIVCHNYYMRSISNSLLANLAFWDFLIIFFCLPLVIFHELTKKWLLGDFSCKIVPYIEVA 82
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755547671 109 CCTASIMGLCIISIDRY-IGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIgPLFGWRQQAPED 172
Cdd:cd15127   83 SLGVTTFTLCALCIDRFrAATNVQMYYEMIENCTSTTAKLAVIWVGALLLAL-PEVVLRQLSKED 146
7tmA_OR52E-like cd15952
olfactory receptor subfamily 52E and related proteins, member of the class A family of ...
27-163 6.87e-05

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320618  Cd Length: 274  Bit Score: 44.29  E-value: 6.87e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLP-FSAIF-----EI-----LGYWAFG 95
Cdd:cd15952    1 FWIGFPFCAVYLIALLGNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPkMLGIFwfnlrEIsfggcLAQMFFI 80
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755547671  96 RVFCNIWAAVdvlcctasimgLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLF 163
Cdd:cd15952   81 HTFTGMESAV-----------LVAMAFDRYVAICNPLRYTTILTNKVISVIALGIVLRPLLLVLPFVF 137
7tmA_PAR2 cd15370
protease-activated receptor 2, member of the class A family of seven-transmembrane G ...
64-334 7.37e-05

protease-activated receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341349 [Multi-domain]  Cd Length: 280  Bit Score: 44.40  E-value: 7.37e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  64 YIVNLAVADLLLTsTVLPFSAIFEILG-YWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYptivTQRR 142
Cdd:cd15370   38 YMANLALADLLFV-IWFPLKIAYHINGnNWIYGEALCKVLIGFFYGNMYCSILFMTCLSVQRYWVIVNPMSH----SRKK 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 143 GVRAL---LCVWALSLVISIgPLFGWRQQ---APEDETICQINEEPG--------YVLFSALGSFYVPLTIILVMYCRVY 208
Cdd:cd15370  113 ANIAIgisLAIWLLILLVTI-PLYLVKQTvfiPALDITTCHDVLPEQllvgdmfnYFLSLAIGVFLFPAFLTAVAYVLMI 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 209 vvakresRGLKSgLKTDKSDSEqvtlrihrknvpaegsgvssaknkthfsvrllkfsREKKAAKTLGIVVGCFVLCWLP- 287
Cdd:cd15370  192 -------RALKS-SINDESIEK-----------------------------------KRKRAIKLIVTVLVMYLICFTPs 228
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 755547671 288 -FFLVMPIGSFFPNFKPPETVFKIV-FWLGYLNSCINPIIYPCSSQEFK 334
Cdd:cd15370  229 nLLLVVHYFLLKNQGQSSVYAFYITaLCLSTLNSCIDPFVYYFVSHDFR 277
7tmA_OR5H-like cd15409
olfactory receptor subfamily 5H and related proteins, member of the class A family of ...
27-141 7.83e-05

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320531 [Multi-domain]  Cd Length: 279  Bit Score: 44.32  E-value: 7.83e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVD 106
Cdd:cd15409    1 VPLFLVFLAIYLITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFF 80
                         90       100       110
                 ....*....|....*....|....*....|....*
gi 755547671 107 VLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQR 141
Cdd:cd15409   81 GFSATTECFLLAAMAYDRYVAICNPLLYPVVMSNR 115
7tmA_GPR139 cd15919
G-protein-coupled receptor GPR139, member of the class A family of seven-transmembrane G ...
36-224 8.05e-05

G-protein-coupled receptor GPR139, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR139, a vertebrate orphan receptor, is very closely related to GPR142, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and plays an important role in mediating insulin secretion and maintaining glucose homeostasis, whereas GPR139 is expressed almost exclusively in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139. These orphan receptors are phylogenetically clustered with invertebrate FMRFamide receptors such as Drosophila melanogaster DrmFMRFa-R.


Pssm-ID: 320585 [Multi-domain]  Cd Length: 270  Bit Score: 44.12  E-value: 8.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  36 LIIFGVLGNIL--VILSVACHRHLHSvTHYYIVNLAVADLLLTSTVLPFSAIFE--------------ILGYWAFGRVFC 99
Cdd:cd15919   10 LLCLGLPANILtvIILSQLVARRQKS-SYNYLLALAAADILVLFFIVFVDFLLEdfilnkqmpqvldkIIEVLEFSSIHT 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 100 NIWAAVDvlcctasimglciISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIgPLFGWRQQAPEDETICQIN 179
Cdd:cd15919   89 SIWITVP-------------LTIDRYIAVCHPLKYHTVSYPARTRKVIVSVYITCFLTSI-PYYWWPNIWIEDYTSTSMH 154
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 755547671 180 EEpgYVLFSALGSFYVPLTIILVMYCRVYVVAKRES----RGLKSGLKT 224
Cdd:cd15919  155 HV--LIWIHCFTVYLVPCSIFFVLNSIIVYKLRRKSnfrlRGYSTGKTT 201
7tmA_OR10G-like cd15916
olfactory receptor subfamily 10G and related proteins, member of the class A family of ...
38-152 8.82e-05

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320582 [Multi-domain]  Cd Length: 276  Bit Score: 43.98  E-value: 8.82e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  38 IFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLP-FSAIFEILGywafGRVFCNIWAAVDVLC-----CT 111
Cdd:cd15916   12 LLTVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPkMLAGFLEPG----GKVISFGGCVAQLYFfhflgST 87
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 755547671 112 ASIMgLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWA 152
Cdd:cd15916   88 ECFL-YTLMAYDRYLAICHPLHYPTIMTGRLCTRLATGTWV 127
7tmA_OR4Q3-like cd15935
olfactory receptor 4Q3 and related proteins, member of the class A family of ...
41-163 8.98e-05

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320601 [Multi-domain]  Cd Length: 268  Bit Score: 43.98  E-value: 8.98e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  41 VLGNILVILSVACHRHL-HSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMGLCI 119
Cdd:cd15935   15 LLGNLLIVVTVHADPHLlQSPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFFLHFLGGSEMLLLTL 94
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 755547671 120 ISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLF 163
Cdd:cd15935   95 MAYDRYVAICHPLRYLAVMNRQLCIKLLAACWAGGFLHSATQAA 138
7tmA_OR52K-like cd15948
olfactory receptor subfamily 52K and related proteins, member of the class A family of ...
38-139 9.07e-05

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320614 [Multi-domain]  Cd Length: 277  Bit Score: 44.12  E-value: 9.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  38 IFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPfsaifEILGYWAFGRVFCNIWAAVDVL--CCTASIM 115
Cdd:cd15948   13 TVALLGNCTLLYVIKTEPSLHEPMFYFLAMLAVIDLVLSTTTVP-----KILSIFWFNSREINFNACLVQMffLHSFSIM 87
                         90       100
                 ....*....|....*....|....*..
gi 755547671 116 G---LCIISIDRYIGVSYPLRYPTIVT 139
Cdd:cd15948   88 EsavLLAMAFDRYVAICNPLRYATILT 114
7tmA_OR11G-like cd15913
olfactory receptor OR11G and related proteins, member of the class A family of ...
27-163 9.65e-05

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320579  Cd Length: 270  Bit Score: 43.84  E-value: 9.65e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHsvTHYYI------------VNLAV----ADLLLTSTVLPFSAIFEILg 90
Cdd:cd15913    1 ILLFSFFSVIYILTLLGNGAIICAVWWDRRLH--TPMYIllgnfsfleicyVTSTVpnmlVNFLSETKTISFSGCFLQF- 77
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755547671  91 YWAFGrvfcniwaavdvLCCTASIMgLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLF 163
Cdd:cd15913   78 YFFFS------------LGTTECFF-LSVMAFDRYLAICRPLHYPTIMTGQLCGKLVAFCWVCGFLWFLIPVV 137
7tmA_OR2_unk cd15424
olfactory receptor family 2, unknown subfamily, member of the class A family of ...
27-159 1.01e-04

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320544 [Multi-domain]  Cd Length: 277  Bit Score: 43.96  E-value: 1.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPfSAIFEIL---GYWAFGRVFCNIWA 103
Cdd:cd15424    1 ILLFVVILIIYLLTILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLP-QMLAHLLagnGAISFARCTTQMYI 79
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 755547671 104 AVDvLCCTASIMgLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISI 159
Cdd:cd15424   80 ALS-LGSTECLL-LGAMAYDRYLAICHPLLYAAAMGRWRQLQLALSCWAIGFLLSV 133
7tmA_OR52M-like cd15949
olfactory receptor subfamily 52M and related proteins, member of the class A family of ...
29-163 1.02e-04

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320615  Cd Length: 292  Bit Score: 44.00  E-value: 1.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  29 LGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLP-FSAIF-----EILGYWAFGRVFcniw 102
Cdd:cd15949   19 ISIPFCSMYLIAVLGNCTILFIIKSEPSLHQPMYFFLSMLAIIDLVLSTSTMPkLLAIFwfssnEIPLHACLLQMF---- 94
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755547671 103 aavdVLCCTASIMG--LCIISIDRYIGVSYPLRYPTIVTQ----RRGVRALlcvwaLSLVISIGPLF 163
Cdd:cd15949   95 ----LIHSFSAIESgiFLAMAFDRYVAICNPLRHKTILTNttviRIGLAAV-----IRGVLYISPLP 152
7tmA_Mrgpr cd14973
mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G ...
22-326 1.52e-04

mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined. Also included in this family is Mas-related G-protein coupled receptor 1-like (MAS1L) which is only found in primates. The angiotensin-II metabolite angiotensin is an endogenous ligand for MAS1L.


Pssm-ID: 320104 [Multi-domain]  Cd Length: 272  Bit Score: 43.40  E-value: 1.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  22 NISKAILLGVILGGLiifgvLGNILVI--LSVACHRHLHSVthyYIVNLAVADLLLTSTVLPFSAIFEILGYWaFGRVFC 99
Cdd:cd14973    1 LVIFSLTVLLSLCGL-----VGNGLVLwlLGFRIKRNPFSV---YILNLAAADFLFLSCQAIQSLEDLLGGSL-PGFALC 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 100 NIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTivtqRRGVR--ALLC--VWALSLVISIGPLFGWRQQA-PEDET 174
Cdd:cd14973   72 RLLATLMFFSYTVGLSLLAAISTERCLSVLFPIWYRC----HRPKHlsAVVCalLWALSLLLSVLESYFCGFLFwKFNES 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 175 ICQineepgYVLFSALGSFYVPLtiiLVMycrvyvvakresrglksglktdksdseqvtlrihrknvpaegsGVSSAKnk 254
Cdd:cd14973  148 ACR------TFNFLSALLFLLLF---LVM-------------------------------------------CVSSLT-- 173
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755547671 255 thFSVRLLKFSREKKAAKTLGIV---VGCFVLCWLPFFLVMPIGSFFPNFKPPETVFkIVFWLGYLNSCINPIIY 326
Cdd:cd14973  174 --LLIRVQCSSQRRPPTRLYVVIlltVLVFLLCGLPLGIYWFLLLWFSNYLFHTFHP-ISDLLSCVNSSANPIIY 245
7tmA_OR5A1-like cd15417
olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...
27-151 1.81e-04

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320539  Cd Length: 279  Bit Score: 43.02  E-value: 1.81e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLP--FSAIFE----ILGYWAFGRVFCN 100
Cdd:cd15417    1 IILFVLFLGIYLVTLLWNLGLIILIRMDSHLHTPMYFFLSNLSFVDICYSSSITPkmLSDFFReqktISFVGCATQYFVF 80
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 755547671 101 IWAAVdVLCCTASIMGLciisiDRYIGVSYPLRYPTIVTQRrgvralLCVW 151
Cdd:cd15417   81 SGMGL-TECFLLAAMAY-----DRYVAICNPLLYSVIMSPR------LCVQ 119
7tmA_TSH-R cd15964
thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family ...
38-338 2.09e-04

thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. TSH-R plays an important role thyroid physiology, and its activation stimulates the production of thyroxine (T4) and triiodothyronine (T3). Defects in TSH-R are a cause of several types of hyperthyroidism. The receptor is predominantly found on the surface of the thyroid epithelial cells and couples to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production. TSH and cAMP stimulate thyroid cell proliferation, differentiation, and function.


Pssm-ID: 320630 [Multi-domain]  Cd Length: 275  Bit Score: 42.97  E-value: 2.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  38 IFGVLGNILVILSVACHRHLHSVTHYYIVNLAVAD------LLLTSTVLPF--SAIFEILGYWAFGRvFCNIWAAVDVLC 109
Cdd:cd15964   12 LLAILGNVFVLLILLTSHYKLTVPRFLMCNLAFADfcmgiyLLLIASVDLHtrSEYYNHAIDWQTGP-GCNTAGFFTVFA 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 110 CTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQAPEDETICQINEEP---GYVL 186
Cdd:cd15964   91 SELSVYTLTVITLERWYAITFAMRLDRKIRLRHASAIMLGGWVFCFLLALLPLVGVSSYAKVSICLPMDTETPlaqAYIV 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 187 FsALGSFYVPLTIILVMYCRVYVVAKResrglksglktdksdseqvtlrihrknvPAEGSGvssaknkthfsvrllkfSR 266
Cdd:cd15964  171 F-VLMLNIIAFVIICACYIKIYITVRN----------------------------PQYKSG-----------------DK 204
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755547671 267 EKKAAKTLGIVVGCFVLCWLP--FFLVMPIGSffpnfKPPETVF--KIVFWLGY-LNSCINPIIYPCssqeFKKAFQ 338
Cdd:cd15964  205 DTKIAKRMAVLIFTDFICMAPisFYALSAILN-----KPLITVSnsKILLVLFYpLNSCANPFLYAI----FTKAFR 272
7tmA_OR5-like cd15230
olfactory receptor family 5 and related proteins, member of the class A family of ...
26-159 2.13e-04

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320358  Cd Length: 270  Bit Score: 42.88  E-value: 2.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  26 AILLGVILggLI-IFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLP-----FSAIFEILGYWAFGRVFC 99
Cdd:cd15230    1 VPLFVLFL--LIyLITLVGNLGMIVLIRIDSRLHTPMYFFLSNLSFVDICYSSVITPkmlvnFLSEKKTISFAGCAAQFF 78
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 100 NIWAAVDVLCCTASIMglciiSIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISI 159
Cdd:cd15230   79 FFAVFGTTECFLLAAM-----AYDRYVAICNPLLYTVIMSKRVCIQLVAGSYLCGFVNSI 133
7tmA_FFAR1 cd15169
free fatty acid receptor 1, member of the class A family of seven-transmembrane G ...
44-164 2.31e-04

free fatty acid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the mammalian free fatty acid receptor 1 (FFAR1), also called GPR40. FFAR1 is a cell-surface receptor for medium- and long-chain free fatty acids (FFAs). The receptor is most potently activated by eicosatrienoic acid (C20:3), but can also be activated at micromolar concentrations of various fatty acids. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and indirectly increases insulin secretion by enhancing the release of incretin. Free fatty acid receptors (FFARs) belong to the class A G-protein coupled receptors and are comprised of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320297  Cd Length: 284  Bit Score: 43.07  E-value: 2.31e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  44 NILVILSVACHRHLH-SVTHYYIVNLAVADLLLTSTvLPFSAIFEIL-GYWAFGRVFCNIWAAVDVLCCTASIMGLCIIS 121
Cdd:cd15169   18 NVLAIRGATAHARLRlTPSLVYALNLGCSDLLLTVS-LPLKAVEALAsGAWPLPASLCPVFAVAHFAPLYAGGGFLAALS 96
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 755547671 122 IDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLViSIGPLFG 164
Cdd:cd15169   97 AGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLC-HLGLVFG 138
7tmA_OR52R_52L-like cd15951
olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...
27-139 2.35e-04

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320617  Cd Length: 275  Bit Score: 42.72  E-value: 2.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLP-FSAIF-----EILGYWAFGRVFCn 100
Cdd:cd15951    1 VWISIPFCIMYAVALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPkMLSIFwfnsrEIDFSACLTQMFF- 79
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 755547671 101 iwaavdVLCCTASIMGLCI-ISIDRYIGVSYPLRYPTIVT 139
Cdd:cd15951   80 ------IHSFSTMESGIFVaMALDRYVAICNPLRHSTILT 113
7tmA_OR10G6-like cd15942
olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...
41-160 2.63e-04

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320608  Cd Length: 275  Bit Score: 42.81  E-value: 2.63e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  41 VLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSaifeILGYWAFGRVFCNIWAAVDV-----LCCTASIM 115
Cdd:cd15942   15 LSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKV----IAGFLSGGRIISFGGCVTQLfffhfLGCAECFL 90
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 755547671 116 gLCIISIDRYIGVSYPLRYPTIVTQRrgvralLCVWaLSLVISIG 160
Cdd:cd15942   91 -YTVMAYDRFLAICKPLHYSTIMNHR------ACLC-LSLGTWLG 127
7tmA_OR5AP2-like cd15943
olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...
25-159 3.44e-04

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320609 [Multi-domain]  Cd Length: 295  Bit Score: 42.35  E-value: 3.44e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  25 KAILLGVILGGLIIfGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLP-----FSAIFEILGYWAFGRVFC 99
Cdd:cd15943   14 QVILFAVFLVIYLI-TLVGNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAITPkmlvnFLAENKTISFTGCAAQMY 92
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 100 NIWAAVDVLCCTASIMglciiSIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISI 159
Cdd:cd15943   93 FFVAFATTECFLLAVM-----AYDRYVAICNPLLYTVIMSPRVCIQLVAGSYLIGFVNAL 147
7tmA_OR10D-like cd15228
olfactory receptor subfamily 10D and related proteins, member of the class A family of ...
38-154 3.54e-04

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320356 [Multi-domain]  Cd Length: 275  Bit Score: 42.42  E-value: 3.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  38 IFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPfsaifEILGY-WAFGRVFCNIWAAVDV-----LCCT 111
Cdd:cd15228   12 LCTLLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTP-----KMLAYlWGQSRVISLGGCMSQVffyhfLGST 86
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 755547671 112 ASIMgLCIISIDRYIGVSYPLRYPTIVTQRrgVRALLCV--WALS 154
Cdd:cd15228   87 ECLL-YTVMAYDRYVAICHPLRYLLIMNRR--VCALLAAgtWITS 128
7tmA_PGE2_EP2 cd15139
prostaglandin E2 receptor EP2 subtype, member of the class A family of seven-transmembrane G ...
40-327 3.95e-04

prostaglandin E2 receptor EP2 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin E2 receptor EP2, also called prostanoid EP2 receptor, is one of four receptor subtypes whose endogenous physiological ligand is prostaglandin E2 (PGE2). Each of these subtypes (EP1-EP4) have unique but overlapping tissue distributions that activate different intracellular signaling pathways. Stimulation of the EP2 receptor by PGE2 causes cAMP accumulation through G(s) protein activation, which subsequently produces smooth muscle relaxation and mediates the systemic vasodepressor response to PGE2. Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320267 [Multi-domain]  Cd Length: 299  Bit Score: 42.07  E-value: 3.95e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  40 GVLGNI--LVILSV---ACHRHLHSVTHYYIVNLAVADLLLTSTVLPF--SAIFEILGYWAFG--RVFCNIWAAVDVLCC 110
Cdd:cd15139   14 GVLGNVlaLVLLERrrrKEVGRRQSLFHVLVTSLVITDLLGTCLISPVvlASYSRNTTLVGMSpnRLVCGYFGFAMTFFS 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 111 TASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFG---WRQQAPedETICQIN---EEPGY 184
Cdd:cd15139   94 LATMLILLAMALERCLSIGHPYFYERYVSKRCGYVTIPLIYLLCALFCLFPFLGfgkYVQYCP--GTWCFIDmnpEASEH 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 185 VLFSALGSFYVPLTIILVMYCRVYVVAKresrglksglktdksdseqvTLRIHRKNVPAEGS-GVSSAKNKTHFSVrllk 263
Cdd:cd15139  172 RAYANLYATLLLLLIVAVVLCNASVIYH--------------------LVRMYRRRKRNRSSvGGRARSHRRRFSM---- 227
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755547671 264 fSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPETVFKIVFWlgylnsCINPIIYP 327
Cdd:cd15139  228 -AEEVEHLILLVFMTIIFVICSLPLTIQVYMNTFSDSENHKWDLIALRFL------SVNPIIDP 284
7tmA_OR52N-like cd15954
olfactory receptor subfamily 52N and related proteins, member of the class A family of ...
38-139 4.58e-04

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320620  Cd Length: 276  Bit Score: 41.73  E-value: 4.58e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  38 IFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPfsaifeilgywafgRVFCNIW---AAVDVLCCTASI 114
Cdd:cd15954   12 IIAMVGNCGLLYLIWIEEALHRPMYYFLSMLSFTDITLCTTMVP--------------KAMCIFWfnlKEISFNACLVQM 77
                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 755547671 115 MG-----------LCIISIDRYIGVSYPLRYPTIVT 139
Cdd:cd15954   78 FFvhtftgmesgvLMLMALDRYVAICYPLRYATILT 113
7tmA_OR1E-like cd15236
olfactory receptor subfamily 1E and related proteins, member of the class A family of ...
41-156 5.42e-04

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320364 [Multi-domain]  Cd Length: 277  Bit Score: 41.68  E-value: 5.42e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  41 VLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLP-----FSAIFEILGYWA-FGRVFCNIWAAvdvlcCTASI 114
Cdd:cd15236   15 VLGNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVTVPkmlmnMQTQDQSIPYAGcISQMYFFIFFG-----CLDSF 89
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 755547671 115 MgLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLV 156
Cdd:cd15236   90 L-LAVMAYDRYVAICHPLHYTAIMRPELCVLLVAGSWVLTCF 130
7tmA_OR2B2-like cd15432
olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...
27-224 6.01e-04

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320549 [Multi-domain]  Cd Length: 277  Bit Score: 41.69  E-value: 6.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIfeilgywafgrVFCNIWAAVD 106
Cdd:cd15432    1 MVLFVVFLIFYILTLLGNLAIILVSRLDPQLHTPMYFFLSNLSLLDLCYTTSTVPQMLV-----------NLRSPQKTIS 69
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 107 VLCCTASI-----------MGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVW----ALSLVIS----IGPLFGWRQ 167
Cdd:cd15432   70 YGGCVAQLfiflglgstecVLLAVMAFDRFAAICQPLHYSVIMHQRLCQQLAAGAWisgfANSLVQStltlKMPRCGRRR 149
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755547671 168 QapeDETICQ-------------INEEPGYVLFSALgsFYVPLTIILVMYCRVY--VVAKRESRGLKSGLKT 224
Cdd:cd15432  150 V---DHFFCEvpallklscvdttANEAELFVISVLL--LLIPLGLILISYIFIVraVLRIRSAEGRRKAFNT 216
7tmA_PGE2_EP1 cd15144
prostaglandin E2 receptor EP1 subtype, member of the class A family of seven-transmembrane G ...
118-164 6.23e-04

prostaglandin E2 receptor EP1 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin E2 receptor EP1, also called prostanoid EP1 receptor, is one of four receptor subtypes whose endogenous physiological ligand is prostaglandin E2 (PGE2). Each of these subtypes (EP1-EP4) have unique but overlapping tissue distributions that activate different intracellular signaling pathways. It has been shown that stimulation of the EP1 receptor by PGE2 causes smooth muscle contraction and increased intracellular Ca2+ levels; however, it is still unclear whether EP1 receptor is exclusively coupled to G(q/11), which leading to activation of phospholipase C and phosphatidylinositol hydrolysis. Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320272 [Multi-domain]  Cd Length: 294  Bit Score: 41.68  E-value: 6.23e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 755547671 118 CIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFG 164
Cdd:cd15144  100 CAMAVERCVGVTRPLLHSSVVTTTRTKLSLLAIWAVALAVALLPLFR 146
7tmA_GPR65_TDAG8 cd15365
proton-sensing G protein-coupled receptor 65, member of the class A family of ...
64-326 6.72e-04

proton-sensing G protein-coupled receptor 65, member of the class A family of seven-transmembrane G protein-coupled receptors; The T cell death associated gene-8 receptor (TDAG8, also known as GPR65) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Activation of TDAG8 by extracellular acidosis increases the cAMP production, stimulates Rho, and induces stress fiber formation. TDAG8 has also been shown to regulate the extracellular acidosis-induced inhibition of pro-inflammatory cytokine production in peritoneal macrophages.


Pssm-ID: 320487 [Multi-domain]  Cd Length: 277  Bit Score: 41.30  E-value: 6.72e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  64 YIVNLAVADLLLTSTvLPFSAIFEILGY-WAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRR 142
Cdd:cd15365   38 YLFNLSLSDLLYIVI-LPLWIDYLWNGDnWTLSGFVCIFSAFLLYTNFYTSTALLTCIALDRYLAVVHPLKFMHLRTIRT 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 143 GVRALLCVWALSlVISIGPLFGWRQQAPED--ETIC---------QINeepgYVLFSALGSFYVPLTIILVMYCRVYvva 211
Cdd:cd15365  117 ALSVSVAIWLLE-ICFNAVILTWEDSFHESssHTLCydkfpledwQAR----LNLFRICLGYLLPLLIILFCYWKIY--- 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671 212 kresrglkSGLKTDKSDSEQvtlrihrknvpaegsgvssaknkthfsvrllkfsREKKAAKTLGIVVGCFVLCWLPFFLV 291
Cdd:cd15365  189 --------QAVRSNQATEDQ----------------------------------EKKKIFKLLLLITVTFVICFTPYHVV 226
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 755547671 292 MPIGSF-----FPNFKPPETVFKIVFWLGYLNSCINPIIY 326
Cdd:cd15365  227 LLIRSIvepcdCRNAKWLYTLYKITVALTSLNCIADPFLY 266
7tmA_OR52A-like cd15955
olfactory receptor subfamily 52A and related proteins, member of the class A family of ...
29-162 9.82e-04

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320621 [Multi-domain]  Cd Length: 276  Bit Score: 40.91  E-value: 9.82e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  29 LGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLP-FSAIFEILGY-WAFGRVFCNIWaAVD 106
Cdd:cd15955    3 IGIPFCIMFLLAVLGNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPkMLAIFWFQLReISFNACLAQMF-FIH 81
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 755547671 107 VLCCTASIMgLCIISIDRYIGVSYPLRYPTIVTQRRGVR-ALLCVWALSLVISIGPL 162
Cdd:cd15955   82 TLQAFESGI-LLAMALDRYVAICHPLRHSSILTPQVLLGiGVLVVVRAVVLIIPCPL 137
7TM_GPCR_Srx pfam10328
Serpentine type 7TM GPCR chemoreceptor Srx; Chemoreception is mediated in Caenorhabditis ...
38-159 1.09e-03

Serpentine type 7TM GPCR chemoreceptor Srx; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srx is part of the Srg superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 431215  Cd Length: 262  Bit Score: 40.66  E-value: 1.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671   38 IFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSA---IFEILGYWAFGRVFCNIWAAVDVLCctASI 114
Cdd:pfam10328   5 LIGLVANLLVFIAFLKLPSLKNSFGILCLSQAIGNAIICLIFLFYVVpmtLFQNSFLPEWLNSHIIGLIAMGLYE--ISP 82
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 755547671  115 MGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISI 159
Cdd:pfam10328  83 LSHLLIALNRFCAVFFPLKYEKIFSIKNTKIIIIFIWIVSIIFCT 127
7tmA_OR10S1-like cd15941
olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...
41-141 1.32e-03

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320607 [Multi-domain]  Cd Length: 277  Bit Score: 40.60  E-value: 1.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  41 VLGNILVILSVACHRHLHSVTHY-YIVNLAVADLLLTSTVLP-FSAIFEILGYWAFGRVFCNIWA-AVDVLCCTASIMgL 117
Cdd:cd15941   15 VLGNLLILLTIGSDPHLHGLPMYhFLGHLSFLDACLSSVTVPkVLAGLLTLSGRTISFEGCVVQLyAFHFLASTECFL-Y 93
                         90       100
                 ....*....|....*....|....
gi 755547671 118 CIISIDRYIGVSYPLRYPTIVTQR 141
Cdd:cd15941   94 TVMAYDRYLAICHPLHYPTAMNRR 117
7tmA_OR5B-like cd15407
olfactory receptor subfamily 5B and related proteins, member of the class A family of ...
27-164 1.93e-03

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320529  Cd Length: 279  Bit Score: 40.10  E-value: 1.93e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  27 ILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLP-----FSAIFEILGYWAFGR--VFC 99
Cdd:cd15407    1 IPLFIIFTLIYLITLVGNLGMILLILLDSRLHTPMYFFLSNLSLVDIGYSSAVTPkvmagLLTGDKVISYNACAAqmFFF 80
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755547671 100 NIWAAVDvlCCTASIMglciiSIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLV---ISIGPLFG 164
Cdd:cd15407   81 VVFATVE--NFLLASM-----AYDRHAAVCKPLHYTTTMTTKVCACLTIGCYVCGFLnasIHTGNTFR 141
7tmA_GPR171 cd15167
orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G ...
37-159 2.62e-03

orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR171 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. A recent study has been reported that the peptide LENSSPQAPARRLLPP (BigLEN) activates GPR17 to regulate body weight in mice; however the biological role of the receptor remains unknown. GPR171 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320295 [Multi-domain]  Cd Length: 282  Bit Score: 39.74  E-value: 2.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  37 IIF--GVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTsTVLPFSAIFEI-LGYWAFGRVFCNIWAAVDVLCCTAS 113
Cdd:cd15167    9 LIFliGFIGSCFALWAFIQKRSSRKCINIYLINLLTADFLLT-LALPVKIAVDLgIAPWKLKIFHCQVTACLIYINMYLS 87
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 755547671 114 IMGLCIISIDRYIGVSYPLRYPTIvtQRRGVRALL--CVWALSLVISI 159
Cdd:cd15167   88 IIFLGFVSIDRYLQLTHSSKLYRI--QEPGFAKMIsaVVWTLVLFIMV 133
7tmA_OR52W-like cd15956
olfactory receptor subfamily 52W and related proteins, member of the class A family of ...
29-161 3.34e-03

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320622 [Multi-domain]  Cd Length: 275  Bit Score: 39.08  E-value: 3.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  29 LGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCnIWAAVDVL 108
Cdd:cd15956    3 LSLPFCFIYVLSLLGNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPKLLAILWFGATAISSYVC-LSQMFLVH 81
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 755547671 109 CCTASIMG-LCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVwALSLVISIGP 161
Cdd:cd15956   82 AFSAMESGvLVAMALDRFVAICNPLHYATILTLEVVAKAGLLL-ALRGVAIVIP 134
7tmA_GPR87 cd15969
G protein-coupled receptor 87, member of the class A family of seven-transmembrane G ...
63-172 3.78e-03

G protein-coupled receptor 87, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR87 acts as one of multiple receptors for lysophosphatidic acid (LPA). This orphan receptor has been shown to be over-expressed in several malignant tumors including lung squamous cell carcinoma and regulated by p53. GPR87 is phylogenetically closely related to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase.


Pssm-ID: 320635 [Multi-domain]  Cd Length: 283  Bit Score: 39.00  E-value: 3.78e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  63 YYIVNLAVADLLLTSTvLPFSAIFEI-LGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQR 141
Cdd:cd15969   36 FYLKNIVIADLLMTLT-FPFKIIQDSgLGPWNFNFFLCRYTSVLFYASMYTSIVFLGLISLDRYLKVVKPFGDSRMYSIT 114
                         90       100       110
                 ....*....|....*....|....*....|.
gi 755547671 142 RGVRALLCVWALSLVISIGPLFGWRQQAPED 172
Cdd:cd15969  115 FTKVLSACVWLIMAFLSLPNIILTNGQPTED 145
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
36-162 4.46e-03

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 39.02  E-value: 4.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671   36 LIIFgvLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPfsaifEILGYWAFG--RVFCNIWAAVDVLCCTAS 113
Cdd:pfam13853   6 LIIF--LGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLP-----TVLGIFWFGlrEISFEACLTQMFFIHKFS 78
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 755547671  114 IMG---LCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSlVISIGPL 162
Cdd:pfam13853  79 IMEsavLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRS-FILVLPL 129
7tmA_OR1330-like cd15946
olfactory receptor 1330 and related proteins, member of the class A family of ...
41-159 6.07e-03

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320612  Cd Length: 270  Bit Score: 38.23  E-value: 6.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  41 VLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMGLCII 120
Cdd:cd15946   15 LLGNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIFLALGITECTLFSVM 94
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 755547671 121 SIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISI 159
Cdd:cd15946   95 AYDRYVAICHPLRYKVIMSWGLCILMVAGSWVCGVFSSL 133
7tmA_P2Y14 cd15149
P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled ...
64-159 6.78e-03

P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y14 receptor is activated by UDP-sugars and belongs to the G(i) class of the P2Y family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14). P2Y14 receptor has been reported to be involved in a diverse set of physiological responses in many epithelia as well as in immune and inflammatory cells.


Pssm-ID: 320277 [Multi-domain]  Cd Length: 284  Bit Score: 38.29  E-value: 6.78e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547671  64 YIVNLAVADLLLTSTvLPFSAIFEI-LGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRR 142
Cdd:cd15149   37 YLKNIVFADLLMSLT-FPFKILSDVeLGPWQLNVIVCRYSAVIFYLNMYVGIIFFGLIGFDRYYKIVKPLHTSFVQNVGY 115
                         90
                 ....*....|....*..
gi 755547671 143 GVRALLCVWALSLVISI 159
Cdd:cd15149  116 SKALSVVVWMLMAVLSV 132
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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