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Conserved domains on  [gi|755554273|ref|XP_011244355|]
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pyridoxal-dependent decarboxylase domain-containing protein 1 isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
AAT_I super family cl18945
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ...
172-394 9.15e-21

Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).


The actual alignment was detected with superfamily member cd06450:

Pssm-ID: 418510  Cd Length: 345  Bit Score: 94.58  E-value: 9.15e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554273 172 KKPVIYLSAAARPGL---GQYLCNQLglpfpclCRVPCNtmfgSQHQMDVAFLEKLIKDDVERGRLPLLLVANAGTAAVG 248
Cdd:cd06450   94 DKLVIVCSDQAHVSVekaAAYLDVKV-------RLVPVD----EDGRMDPEALEAAIDEDKAEGLNPIMVVATAGTTDTG 162
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554273 249 HTDKIGRLKELCEQYGIWLHVEGvnlatlALGyvsSSVLAATK----------CDSMTLTPGLWLGLPAVPAVTLYkhdd 318
Cdd:cd06450  163 AIDPLEEIADLAEKYDLWLHVDA------AYG---GFLLPFPEprhldfgierVDSISVDPHKYGLVPLGCSAVLV---- 229
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755554273 319 paltlvagltsnkpadklRALPLWLSLQYLGLDGIVERIKHACHLSQRLQESLKKVDHIKILVEDELssPVVVFRF 394
Cdd:cd06450  230 ------------------RALKLWATLRRFGRDGYGEHIDRIVDLAKYLAELIRADPGFELLGEPNL--SLVCFRL 285
 
Name Accession Description Interval E-value
DOPA_deC_like cd06450
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent ...
172-394 9.15e-21

DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and glutamate decarboxylase (GDC). DDC is active as a dimer and catalyzes the decarboxylation of tyrosine. GDC catalyzes the decarboxylation of glutamate and HDC catalyzes the decarboxylation of histidine.


Pssm-ID: 99743  Cd Length: 345  Bit Score: 94.58  E-value: 9.15e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554273 172 KKPVIYLSAAARPGL---GQYLCNQLglpfpclCRVPCNtmfgSQHQMDVAFLEKLIKDDVERGRLPLLLVANAGTAAVG 248
Cdd:cd06450   94 DKLVIVCSDQAHVSVekaAAYLDVKV-------RLVPVD----EDGRMDPEALEAAIDEDKAEGLNPIMVVATAGTTDTG 162
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554273 249 HTDKIGRLKELCEQYGIWLHVEGvnlatlALGyvsSSVLAATK----------CDSMTLTPGLWLGLPAVPAVTLYkhdd 318
Cdd:cd06450  163 AIDPLEEIADLAEKYDLWLHVDA------AYG---GFLLPFPEprhldfgierVDSISVDPHKYGLVPLGCSAVLV---- 229
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755554273 319 paltlvagltsnkpadklRALPLWLSLQYLGLDGIVERIKHACHLSQRLQESLKKVDHIKILVEDELssPVVVFRF 394
Cdd:cd06450  230 ------------------RALKLWATLRRFGRDGYGEHIDRIVDLAKYLAELIRADPGFELLGEPNL--SLVCFRL 285
GadA COG0076
Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport ...
164-394 7.61e-17

Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport and metabolism];


Pssm-ID: 223154 [Multi-domain]  Cd Length: 460  Bit Score: 83.96  E-value: 7.61e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554273 164 DGFNVLYNKKPVIYLSAAARPGLgQYLCNQLGLPfpcLCRVPcntMFGSQHQMDVAFLEKLIKDDVERGrlplLLVANAG 243
Cdd:COG0076  148 LAESGKPGGKPNIVCSETAHFSF-EKAARYLGLG---LRRVP---TVPTDYRIDVDALEEAIDENTIGG----VVVGTAG 216
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554273 244 TAAVGHTDKIGRLKELCEQYGIWLHVEGvnlatlALGyvsSSVLAATKC-----------DSMTLTPGLWLGLPAVPAVT 312
Cdd:COG0076  217 TTDTGSIDDIEELADIAEEYGIWLHVDA------AFG---GFLLPFLEPdgrwdfglegvDSITVDGHKYGLAPIGCGVV 287
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554273 313 LYK----------HDDPALT----LVAGLTSNKPADklRALPLWLSLQYLGLDGIVERIKHACHLSQRLQESLKKVDHIK 378
Cdd:COG0076  288 LFRdeealrriliFADYYLPgggiPNFTILGSRPGR--QALALYANLRRLGREGYRKLLDRTLELARYLAEELEKLGDFE 365
                        250
                 ....*....|....*.
gi 755554273 379 ILVEDELssPVVVFRF 394
Cdd:COG0076  366 LVNEPEL--PIVAFRL 379
Pyridoxal_deC pfam00282
Pyridoxal-dependent decarboxylase conserved domain;
171-393 1.08e-10

Pyridoxal-dependent decarboxylase conserved domain;


Pssm-ID: 395219  Cd Length: 373  Bit Score: 63.98  E-value: 1.08e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554273  171 NKKPVIYLSAAArpglgQYLCNQLGLPFPCLCR-VPCNtmfgSQHQMDVAFLEKLIKDDVERGRLPLLLVANAGTAAVGH 249
Cdd:pfam00282 143 LAKLVAYTSDQA-----HSSIEKAALYGGVKLReIPSD----DNGKMRGMDLEKAIEEDKENGLIPFFVVATLGTTGSGA 213
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554273  250 TDKIGRLKELCEQYGIWLHVEGVNLATLALG-YVSSSVLAATKCDSMTLTPGLWLGLPAvPAVTLYKHDDPALTLVAGL- 327
Cdd:pfam00282 214 FDDLQELGDICAKHNLWLHVDAAYGGSAFICpEFRHWLFGIERADSITFNPHKWMLVLL-DCSAVWVKDKEALQQAFQFn 292
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554273  328 -----TSNKPAD----------KLRALPLWLSLQYLGLDGIVERIKHACHLSQRLQESLKKVDHIKILVEDELssPVVVF 392
Cdd:pfam00282 293 plylgHTDSAYDtghkqiplsrRFRILKLWFVIRSLGVEGLQNQIRRHVELAQYLEALIRKDGRFEICAEVGL--GLVCF 370

                  .
gi 755554273  393 R 393
Cdd:pfam00282 371 R 371
PRK13520 PRK13520
tyrosine decarboxylase MfnA;
212-393 2.52e-06

tyrosine decarboxylase MfnA;


Pssm-ID: 237409  Cd Length: 371  Bit Score: 50.27  E-value: 2.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554273 212 SQHQMDVAFLEKLIKDDVergrlpLLLVANAGTAAVGHTDKIGRLKELCEQYGIWLHVE----GVNLATLALGYVSSSVL 287
Cdd:PRK13520 135 DDYRVDVKAVEDLIDDNT------IGIVGIAGTTELGQVDPIPELSKIALENGIFLHVDaafgGFVIPFLDDPPNFDFSL 208
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554273 288 AATkcDSMTLTPGLwLGLPAVPA-VTLYKH---------DDPALT--LVAGLTSNKPAdkLRALPLWLSLQYLGLDGIVE 355
Cdd:PRK13520 209 PGV--DSITIDPHK-MGLAPIPAgGILFRDesyldalavDTPYLTskKQATLTGTRSG--AGVAATYAVMKYLGREGYRK 283
                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 755554273 356 RIKHACHLSQRLQESLKKVDhIKILVEDELssPVVVFR 393
Cdd:PRK13520 284 VVERCMENTRWLAEELKERG-FEPVIEPVL--NIVAFD 318
 
Name Accession Description Interval E-value
DOPA_deC_like cd06450
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent ...
172-394 9.15e-21

DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and glutamate decarboxylase (GDC). DDC is active as a dimer and catalyzes the decarboxylation of tyrosine. GDC catalyzes the decarboxylation of glutamate and HDC catalyzes the decarboxylation of histidine.


Pssm-ID: 99743  Cd Length: 345  Bit Score: 94.58  E-value: 9.15e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554273 172 KKPVIYLSAAARPGL---GQYLCNQLglpfpclCRVPCNtmfgSQHQMDVAFLEKLIKDDVERGRLPLLLVANAGTAAVG 248
Cdd:cd06450   94 DKLVIVCSDQAHVSVekaAAYLDVKV-------RLVPVD----EDGRMDPEALEAAIDEDKAEGLNPIMVVATAGTTDTG 162
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554273 249 HTDKIGRLKELCEQYGIWLHVEGvnlatlALGyvsSSVLAATK----------CDSMTLTPGLWLGLPAVPAVTLYkhdd 318
Cdd:cd06450  163 AIDPLEEIADLAEKYDLWLHVDA------AYG---GFLLPFPEprhldfgierVDSISVDPHKYGLVPLGCSAVLV---- 229
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755554273 319 paltlvagltsnkpadklRALPLWLSLQYLGLDGIVERIKHACHLSQRLQESLKKVDHIKILVEDELssPVVVFRF 394
Cdd:cd06450  230 ------------------RALKLWATLRRFGRDGYGEHIDRIVDLAKYLAELIRADPGFELLGEPNL--SLVCFRL 285
GadA COG0076
Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport ...
164-394 7.61e-17

Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport and metabolism];


Pssm-ID: 223154 [Multi-domain]  Cd Length: 460  Bit Score: 83.96  E-value: 7.61e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554273 164 DGFNVLYNKKPVIYLSAAARPGLgQYLCNQLGLPfpcLCRVPcntMFGSQHQMDVAFLEKLIKDDVERGrlplLLVANAG 243
Cdd:COG0076  148 LAESGKPGGKPNIVCSETAHFSF-EKAARYLGLG---LRRVP---TVPTDYRIDVDALEEAIDENTIGG----VVVGTAG 216
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554273 244 TAAVGHTDKIGRLKELCEQYGIWLHVEGvnlatlALGyvsSSVLAATKC-----------DSMTLTPGLWLGLPAVPAVT 312
Cdd:COG0076  217 TTDTGSIDDIEELADIAEEYGIWLHVDA------AFG---GFLLPFLEPdgrwdfglegvDSITVDGHKYGLAPIGCGVV 287
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554273 313 LYK----------HDDPALT----LVAGLTSNKPADklRALPLWLSLQYLGLDGIVERIKHACHLSQRLQESLKKVDHIK 378
Cdd:COG0076  288 LFRdeealrriliFADYYLPgggiPNFTILGSRPGR--QALALYANLRRLGREGYRKLLDRTLELARYLAEELEKLGDFE 365
                        250
                 ....*....|....*.
gi 755554273 379 ILVEDELssPVVVFRF 394
Cdd:COG0076  366 LVNEPEL--PIVAFRL 379
Pyridoxal_deC pfam00282
Pyridoxal-dependent decarboxylase conserved domain;
171-393 1.08e-10

Pyridoxal-dependent decarboxylase conserved domain;


Pssm-ID: 395219  Cd Length: 373  Bit Score: 63.98  E-value: 1.08e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554273  171 NKKPVIYLSAAArpglgQYLCNQLGLPFPCLCR-VPCNtmfgSQHQMDVAFLEKLIKDDVERGRLPLLLVANAGTAAVGH 249
Cdd:pfam00282 143 LAKLVAYTSDQA-----HSSIEKAALYGGVKLReIPSD----DNGKMRGMDLEKAIEEDKENGLIPFFVVATLGTTGSGA 213
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554273  250 TDKIGRLKELCEQYGIWLHVEGVNLATLALG-YVSSSVLAATKCDSMTLTPGLWLGLPAvPAVTLYKHDDPALTLVAGL- 327
Cdd:pfam00282 214 FDDLQELGDICAKHNLWLHVDAAYGGSAFICpEFRHWLFGIERADSITFNPHKWMLVLL-DCSAVWVKDKEALQQAFQFn 292
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554273  328 -----TSNKPAD----------KLRALPLWLSLQYLGLDGIVERIKHACHLSQRLQESLKKVDHIKILVEDELssPVVVF 392
Cdd:pfam00282 293 plylgHTDSAYDtghkqiplsrRFRILKLWFVIRSLGVEGLQNQIRRHVELAQYLEALIRKDGRFEICAEVGL--GLVCF 370

                  .
gi 755554273  393 R 393
Cdd:pfam00282 371 R 371
PRK13520 PRK13520
tyrosine decarboxylase MfnA;
212-393 2.52e-06

tyrosine decarboxylase MfnA;


Pssm-ID: 237409  Cd Length: 371  Bit Score: 50.27  E-value: 2.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554273 212 SQHQMDVAFLEKLIKDDVergrlpLLLVANAGTAAVGHTDKIGRLKELCEQYGIWLHVE----GVNLATLALGYVSSSVL 287
Cdd:PRK13520 135 DDYRVDVKAVEDLIDDNT------IGIVGIAGTTELGQVDPIPELSKIALENGIFLHVDaafgGFVIPFLDDPPNFDFSL 208
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554273 288 AATkcDSMTLTPGLwLGLPAVPA-VTLYKH---------DDPALT--LVAGLTSNKPAdkLRALPLWLSLQYLGLDGIVE 355
Cdd:PRK13520 209 PGV--DSITIDPHK-MGLAPIPAgGILFRDesyldalavDTPYLTskKQATLTGTRSG--AGVAATYAVMKYLGREGYRK 283
                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 755554273 356 RIKHACHLSQRLQESLKKVDhIKILVEDELssPVVVFR 393
Cdd:PRK13520 284 VVERCMENTRWLAEELKERG-FEPVIEPVL--NIVAFD 318
PLN02880 PLN02880
tyrosine decarboxylase
172-429 2.88e-05

tyrosine decarboxylase


Pssm-ID: 215475  Cd Length: 490  Bit Score: 47.21  E-value: 2.88e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554273 172 KKPVIYLSAAARPGLgQYLCnQLGLPFPCLCRV---PCNTMFGSQHQMdvafLEKLIKDDVERGRLPLLLVANAGTAAVG 248
Cdd:PLN02880 180 EKLVVYASDQTHSAL-QKAC-QIAGIHPENCRLlktDSSTNYALAPEL----LSEAISTDLSSGLIPFFLCATVGTTSST 253
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554273 249 HTDKIGRLKELCEQYGIWLHVEGvnlatlalGYVSSSVL---------AATKCDSMTLTPGLWLgLPAVPAVTLYKHDDP 319
Cdd:PLN02880 254 AVDPLLELGKIAKSNGMWFHVDA--------AYAGSACIcpeyrhyidGVEEADSFNMNAHKWF-LTNFDCSLLWVKDRN 324
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554273 320 ALTLVAG----LTSNKPAD----------------KLRALPLWLSLQYLGLDGIVERIKHACHLSQRLQEslkkvdhiki 379
Cdd:PLN02880 325 ALIQSLStnpeFLKNKASQansvvdykdwqiplgrRFRSLKLWMVLRLYGVENLQSYIRNHIKLAKEFEQ---------- 394
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 755554273 380 LVEDELSSPVVVFRFFqelpaSDSAFKAVPVSNIAPAAVGRERHSCDALN 429
Cdd:PLN02880 395 LVAQDSRFEVVTPRIF-----SLVCFRLVPPKNNEDNGNKLNHDLLDAVN 439
PLN02590 PLN02590
probable tyrosine decarboxylase
221-429 1.14e-04

probable tyrosine decarboxylase


Pssm-ID: 178200  Cd Length: 539  Bit Score: 45.47  E-value: 1.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554273 221 LEKLIKDDVERGRLPLLLVANAGTAAVGHTDKIGRLKELCEQYGIWLHVEGVNLATLALGYVSSSVLAATK-CDSMTLTP 299
Cdd:PLN02590 274 LEEAISHDLAKGFIPFFICATVGTTSSAAVDPLVPLGNIAKKYGIWLHVDAAYAGNACICPEYRKFIDGIEnADSFNMNA 353
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554273 300 GLWLgLPAVPAVTLYKHDdpALTLVAGLTSNKP----------------------ADKLRALPLWLSLQYLGLDGIVERI 357
Cdd:PLN02590 354 HKWL-FANQTCSPLWVKD--RYSLIDALKTNPEylefkvskkdtvvnykdwqislSRRFRSLKLWMVLRLYGSENLRNFI 430
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755554273 358 KHACHLSQRLQESLKKVDHIKilvedelsspVVVFRFFqelpaSDSAFKAVPVSNIAPAAVGRERHSCDALN 429
Cdd:PLN02590 431 RDHVNLAKHFEDYVAQDPSFE----------VVTTRYF-----SLVCFRLAPVDGDEDQCNERNRELLAAVN 487
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.19
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
  • Marchler-Bauer A et al. (2015), "CDD: NCBI's conserved domain database.", Nucleic Acids Res.43(D)222-6.
  • Marchler-Bauer A et al. (2011), "CDD: a Conserved Domain Database for the functional annotation of proteins.", Nucleic Acids Res.39(D)225-9.
  • Marchler-Bauer A, Bryant SH (2004), "CD-Search: protein domain annotations on the fly.", Nucleic Acids Res.32(W)327-331.
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