NCBI Conserved Domain Search

Kelch domain;

426-471

3.16e-11

Kelch domain;

Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 58.34 E-value: 3.16e-11

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 755564624   426 LYAVGGRNAAGELPTVECYNPRTNEWTYVAKMNEPHYGHAGTVYGG 471
Cdd:smart00612   2 IYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47

BTB_POZ

cd01165

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

85-157

3.58e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.

Pssm-ID: 349496 [Multi-domain] Cd Length: 79 Bit Score: 59.22 E-value: 3.58e-11

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755564624  85 DDAYPVHRVMMASASDYFKAMFTGGMKEQELMCIKLHGVSRVGLRKIIDFIYTAKLSLNMDTLQDTLEAASFL 157
Cdd:cd01165    7 GEKFHVNKELLAQSSEYFRALFRGGFRESGQAEINLRDISPEDFRALLEFLYGGKRDLDASNLLELLEAANFL 79

BACK_KLHL1_like

cd18444

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; ...

178-273

6.26e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This subfamily contains Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. Members of this subfamily contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels.

Pssm-ID: 350519 [Multi-domain] Cd Length: 106 Bit Score: 59.65 E-value: 6.26e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624 178 NCVEVGRIANTYHLTEVDKYVNSFVLKNFAALLSTGEFLKLPFERLAFVLSSNSLKRCTELDLFKATCRWLRLEEP-RMD 256
Cdd:cd18444    6 NCLGIRSFADAQGCTDLLKVAHNYTMEHFMEVIQNQEFLLLPAEEVAKLLASDDLNVPSEETIFHALLLWVKHDLPeRKK 85

                         90
                 ....*....|....*..
gi 755564624 257 VAAKLMKNIRFPLMTPQ 273
Cdd:cd18444   86 HLAKLLALIRLPLLTPQ 102

PHA02790

Kelch-like protein; Provisional

128-477

9.08e-11

Kelch-like protein; Provisional

Pssm-ID: 165153 [Multi-domain] Cd Length: 480 Bit Score: 64.68 E-value: 9.08e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624 128 LRKIIDFIYTAKLSLNMDTLQDTLEAASFLQILPVLDFCKVFLISGVTLDNCVEVGRIANTYHLTEVDKYVNSFVLKNFA 207
Cdd:PHA02790  74 LTSIVIYSYTGKVYIDSHNVVNLLRASILTSVEFIIYTCINFILRDFRKEYCVECYMMGIEYGLSNLLCHTKDFIAKHFL 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624 208 ALlSTGEFLKLPFERLAFVLSSNSLKRCTELDLFKATCRWLRLEEPRMDVAAKLMKN-IRFPLMTPQELINYVQTVDFMR 286
Cdd:PHA02790 154 EL-EDDIIDNFDYLSMKLILESDELNVPDEDYVVDFVIKWYMKRRNRLGNLLLLIKNvIRSNYLSPRGINNVKWILDCTK 232

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624 287 TDNtCVNLLLEASNYqmmPFMQPVMQSDR------TAIRSDTTRLVTL-GGVLRQQlvVSKELRMYDEKTHEWKSLAPMD 359
Cdd:PHA02790 233 IFH-CDKQPRKSYKY---PFIEYPMNMDQiidifhMCTSTHVGEVVYLiGGWMNNE--IHNNAIAVNYISNNWIPIPPMN 306

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624 360 APR-YQHGIAViGNFLYVVGGQSNydtkgKTAVDTVFRFDpryNKWIQVASLNEKRTFFHLSALKGFLYAVGGRNAAGEl 438
Cdd:PHA02790 307 SPRlYASGVPA-NNKLYVVGGLPN-----PTSVERWFHGD---AAWVNMPSLLKPRCNPAVASINNVIYVIGGHSETDT- 376

                        330       340       350
                 ....*....|....*....|....*....|....*....
gi 755564624 439 pTVECYNPRTNEWTYVAKMNEPHYGHAGTVYGGVMYISG 477
Cdd:PHA02790 377 -TTEYLLPNHDQWQFGPSTYYPHYKSCALVFGRRLFLVG 414

BTB_POZ_KLHL41_KBTBD10

cd18341

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

57-182

1.08e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349650 [Multi-domain] Cd Length: 133 Bit Score: 59.86 E-value: 1.08e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624  57 HSSVVLQ-GFDQLRLDGLLCDVTLMPGDTddAYPVHRVMMASASDYFKAMFTGGMKEQELMCIKLHGVSRVGLRKIIDFI 135
Cdd:cd18341    9 YQSTLLQdGLKELLDENKFVDCTLKAGDK--SLPCHRLILAACSPYFREYFLSEESEEKKKEVVLDNVDPNIMDMILKYL 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 755564624 136 YTAKLSLNMDTLQDTLEAASFLQILPVLDFCKVFLISGVTLDNCVEV 182
Cdd:cd18341   87 YSAEIDLNDGNVQDIFALASRFQIPSVFTVCVTYLQKRLSPANCLAI 133

BTB_POZ_ZBTB37

cd18222

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

58-170

1.10e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349531 [Multi-domain] Cd Length: 123 Bit Score: 59.29 E-value: 1.10e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624  58 SSVVLQGFDQLRLDGLLCDVTLmpGDTDDAYPVHRVMMASASDYFK-AMFTGGMKEQELMCIKLHGVsrvgLRKIIDFIY 136
Cdd:cd18222    9 SNSVLSHLNQLRMQGRLCDIVV--NVQGQSFRAHKVVLAASSPYFRdHMSLNEMSTVSISVIKNPTV----FEQLLSFCY 82

                         90       100       110
                 ....*....|....*....|....*....|....
gi 755564624 137 TAKLSLNMDTLQDTLEAASFLQILPVLDFCKVFL 170
Cdd:cd18222   83 TGRICLQLADIISYLTAASFLQMQHIIDKCTQIL 116

BTB_POZ_ZBTB8

cd18199

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

57-170

1.27e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349508 [Multi-domain] Cd Length: 113 Bit Score: 58.97 E-value: 1.27e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624  57 HSSVVLQGFDQLRLDGLLCDVTLMPgdTDDAYPVHRVMMASASDYFKAMFTGGMKE-QELMCIKLHGVSRVGLRKIIDFI 135
Cdd:cd18199    1 HQSRLLGQLNEQRKQDFFCDCSIIV--EGRIFKAHRNVLFASSGYFRMLLSHYIQDtGRPSTASFDVFSSDAFSIILDFV 78

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 755564624 136 YTAKLSLNMDTLQDTLEAASFLQILPVLDFCKVFL 170
Cdd:cd18199   79 YSGKLSLTSQNVIEVMSAASYLQMTDVINVCKTFI 113

BACK

cd14733

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...

175-229

1.49e-10

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.

Pssm-ID: 350515 [Multi-domain] Cd Length: 55 Bit Score: 56.90 E-value: 1.49e-10

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 755564624 175 TLDNCVEVGRIANTYHLTEVDKYVNSFVLKNFAALLSTGEFLKLPFERLAFVLSS 229
Cdd:cd14733    1 DPENCLGILELADLYNLEELKEKALKFILENFEEVSKSEEFLELSVELLLELLSS 55

BTB_POZ_ABTB2-like

cd18297

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

91-178

2.81e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349606 [Multi-domain] Cd Length: 117 Bit Score: 58.05 E-value: 2.81e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624  91 HRVMMASASDYFKAMFTGGMKEQELMCIKLHGVSRVGLRKIIDFIYTAK---LSLNMDTLQDTLEAASFLQILPVLDFCK 167
Cdd:cd18297   27 HKIVLVTASDRFKSMLSSGSTEAQTPVIEIPDIRYDIFQLMMQYLYTGGvesLDVAQDDALELLRAASFFQLDGLKRHCE 106

                         90
                 ....*....|.
gi 755564624 168 VFLISGVTLDN 178
Cdd:cd18297  107 ILLSQQIDLDN 117

BACK_KLHL14

cd18453

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 14 (KLHL14); KLHL14, also ...

174-283

3.07e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 14 (KLHL14); KLHL14, also termed protein interactor of Torsin-1A, or Printor, or protein interactor of torsinA, is a novel ATP-free form of torsinA-interacting protein implicated in dystonia pathogenesis.

Pssm-ID: 350528 Cd Length: 102 Bit Score: 57.33 E-value: 3.07e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624 174 VTLDNCVEVGRIANTYHLTEVDKYVNSFVLKnfaallstgEFLKLPFERLAFVLSSNSLKRCTELDLFKATCRWLRLE-E 252
Cdd:cd18453    1 ISVQNYKQVCKIAALHGLEETKKLANKYLVE---------DVLLLNFEEMRAMLDSLPPPVESELALFQMSVLWLEHDrE 71

                         90       100       110
                 ....*....|....*....|....*....|.
gi 755564624 253 PRMDVAAKLMKNIRFPLMTPQELINYVQTVD 283
Cdd:cd18453   72 TRMQYAPDLMKRLRFALIPAPELVERVQSVD 102

BTB_POZ_ZBTB4

cd18195

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

57-161

3.55e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349504 [Multi-domain] Cd Length: 124 Bit Score: 57.98 E-value: 3.55e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624  57 HSSVVLQGFDQLRLDGLLCDVTLMPGDTDdaYPVHRVMMASASDYFK-------------AMFTGGMKEQELMCIKLHGV 123
Cdd:cd18195    1 HAGALLLQLNEQRLRGLFCDVTLIAGDTK--FRAHRSVLAASSPYFRellssplplgaaaVAAAPGATQSPERVLELPGV 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 755564624 124 SRVGLRKIIDFIYTAKLSLNMDTLQDTLEAA------SFLQILP 161
Cdd:cd18195   79 KAGVFSDVLNFIYSSRVALPGSAAAKELGAAgkrlgiPFLQGLE 122

BTB_POZ_BACH

cd18955

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

74-170

3.92e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349736 [Multi-domain] Cd Length: 94 Bit Score: 57.09 E-value: 3.92e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624  74 LCDVTLMPGDtdDAYPVHRVMMASASDYFKAMFTGGMKEQelMCIKL-HGVSRVGLRKIIDFIYTAKLSLNMDTLQDTLE 152
Cdd:cd18955    1 LCDVTIVVED--QRFRAHRAVLAACSDYFLSRVVGQTDGD--LVITLpEEVTVKGFEPLLQFAYTAKLLLSKENVLEVCR 76

                         90
                 ....*....|....*...
gi 755564624 153 AASFLQILPVLDFCKVFL 170
Cdd:cd18955   77 CAEFLGVHNIEKACFDFL 94

BACK_BTBD9

cd14822

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); ...

185-275

5.08e-10

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation.

Pssm-ID: 350518 [Multi-domain] Cd Length: 101 Bit Score: 56.85 E-value: 5.08e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624 185 IANTYHLTEVDKYVNSFVLKNFAALLSTGEFLKLPFERLAFVLSSNSLKrCTELDLFKATCRWLRLEEPRMDVAAKLMKN 264
Cdd:cd14822   12 VASLYSLDDLCQTCCQFMDRNAQEVLSSEGFLTLSKSALKELLSRDSFC-APEVDIFNAVRRWCEHNPDSKEDAKEILEA 90

                         90
                 ....*....|.
gi 755564624 265 IRFPLMTPQEL 275
Cdd:cd14822   91 VRLPLMSLTEL 101

BTB_POZ_trishanku-like

cd18314

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...

76-166

5.41e-10

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349623 [Multi-domain] Cd Length: 96 Bit Score: 56.58 E-value: 5.41e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624  76 DVTLMPGDTDdaYPVHRVMMASASDYFKAMFTGGMKEQELMCIKLHGVSRVGLRKIIDFIYTAKLSLNMDTLQDTLEAAS 155
Cdd:cd18314    8 DVVLCVGDRK--FFAHRIVLCARSPVFRSMLTGSMIESNLKEVTLEDVEPEIFETVLKYMYTGQVTLSEENVLDLLMLAS 85

                         90
                 ....*....|.
gi 755564624 156 FLQILPVLDFC 166
Cdd:cd18314   86 KYQVPDLEKLC 96

BTB_POZ_ZBTB30_HIC2

cd18334

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

56-167

9.53e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349643 [Multi-domain] Cd Length: 120 Bit Score: 56.51 E-value: 9.53e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624  56 SHSSVVLQGFDQLRLDGLLCDVTLMPGDTddAYPVHRVMMASASDYFKAMftggMKEQELMCIKLHGVSRVGLRKIIDFI 135
Cdd:cd18334    3 NHAKQLLLQLNQQRAKGFLCDVIIVVENA--LFRAHKNILAASSMYFKSL----VLHDNLINLDTDMVNPTVFRQILDFI 76

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 755564624 136 YTAKL-------SLNMDTLqdtLEAASFLQILPVLDFCK 167
Cdd:cd18334   77 YTGKLltsdqpgEQNFNAL---LTAASYLQLHDLAALCR 112

BACK_KLHL22

cd18461

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a ...

177-270

1.09e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of Polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation.

Pssm-ID: 350536 Cd Length: 104 Bit Score: 55.92 E-value: 1.09e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624 177 DNCVEVGRIANTYHLTEVDKYVNSFVLKNFAALLSTGEFLKLPFERLAFVLSSNSLKRCTELDLFKA------TCRWLRL 250
Cdd:cd18461    4 ENILDVYKLADLFHLTHLSEQLDSYILKNFPTFSRTETYRQLPLEKVYSLLSSNRLEVDSENEVYEGallyhyTPEQVEK 83

                         90       100
                 ....*....|....*....|
gi 755564624 251 EEPRMDVAAKLMKNIRFPLM 270
Cdd:cd18461   84 DQVSLQEPPKLLEAVRFPLM 103

BTB_POZ_ZBTB11

cd18202

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

57-167

1.32e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349511 [Multi-domain] Cd Length: 118 Bit Score: 56.01 E-value: 1.32e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624  57 HSSVVLQGFDQLRLDGLLCDVTLMPgdTDDAYPVHRVMMASASDYFKAMFT--GGMKEQELMcIKLHGVSRVGLRKIIDF 134
Cdd:cd18202    2 HGQTVLDQLNQQRLNNQFCDVTLLI--EGEEYKAHKSVLAANSEYFRELFIekGAVSSHEAV-VDLSGFCKSSFLPLLEF 78

                         90       100       110
                 ....*....|....*....|....*....|...
gi 755564624 135 IYTAKLSLNMDTLQDTLEAASFLQILPVLDFCK 167
Cdd:cd18202   79 AYTSELTFDFCSMAEVAMLARHLFMNEVLEICE 111

BTB2_POZ_RhoBTB

cd18300

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

71-174

1.40e-09

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349609 [Multi-domain] Cd Length: 108 Bit Score: 55.71 E-value: 1.40e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624  71 DGLLCDVTLMPGDTddAYPVHRVMMASASDYFKAMFTGGMKEQELMCIKLHGVSRVGLRKIIDFIYTAKLSL--NMDTLq 148
Cdd:cd18300    6 KGLFSDVTFIVEDG--TIPAHKALLVARCDVMAAMFGGNFRESSAKEVELPGVSKETFLALLEYLYTDQAPIleDGDCV- 82

                         90       100
                 ....*....|....*....|....*.
gi 755564624 149 DTLEAASFLQILPVLDFCKVFLISGV 174
Cdd:cd18300   83 GLIVLANRLCLPRLVALCEQYIVKEL 108

BTB_POZ_ZBTB5

cd18196

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

57-172

1.52e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 5 (ZBTB5); ZBTB5 is a POZ domain Kruppel-like zinc finger (POK) family transcription repressor of cell cycle arrest gene p21 and a potential proto-oncogene stimulating cell proliferation. ZBTB5 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349505 [Multi-domain] Cd Length: 126 Bit Score: 56.21 E-value: 1.52e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624  57 HSSVVLQGFDQLRLDGLLCDVTLMPGDTDdaYPVHRVMMASASDYFKAMFTGGMKEQELMCIKLHG--VSRVGLRKIIDF 134
Cdd:cd18196    4 HFEQIFQQLNYQRLHGQLCDCVIVVGNRH--FKAHRSVLAACSTHFRALFTVAEGDQTMNMIQLDSevVTAEAFAALIDM 81

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 755564624 135 IYTAKLSLNMDTLQDTLEAASFLQILPVLDFCKVFLIS 172
Cdd:cd18196   82 MYTSTLMLGESNVMDVLLAASHLHLNSVVKACKHYLTT 119

PLN02193

nitrile-specifier protein

361-620

1.54e-09

nitrile-specifier protein

Pssm-ID: 177844 [Multi-domain] Cd Length: 470 Bit Score: 60.74 E-value: 1.54e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624 361 PRYQHGIAVIGNFLYVVGGQsnydtkgktavdtvfrFDPR--YNKWIQVASLnEKRTfFHLSAlkgflyavggrnAAGEL 438
Cdd:PLN02193 165 LRCSHGIAQVGNKIYSFGGE----------------FTPNqpIDKHLYVFDL-ETRT-WSISP------------ATGDV 214

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624 439 PTVECYNPRTnewtyvakmnephyghagTVYGGVMYISGGITHDTFQKELMCFDPDTDKWTQKAPMT---TVRGLHCMCT 515
Cdd:PLN02193 215 PHLSCLGVRM------------------VSIGSTLYVFGGRDASRQYNGFYSFDTTTNEWKLLTPVEegpTPRSFHSMAA 276

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624 516 VGDRLYVIGgnhfrGTSDYDDVLSCEYYSPILDQW----TPIASM-LRGQSdvGVAVFENKIYVVGGYswnNRCMVEIVQ 590
Cdd:PLN02193 277 DEENVYVFG-----GVSATARLKTLDSYNIVDKKWfhcsTPGDSFsIRGGA--GLEVVQGKVWVVYGF---NGCEVDDVH 346

                        250       260       270
                 ....*....|....*....|....*....|
gi 755564624 591 KYDPEKNEWHKVfdlpESLgGIRACTLTVY 620
Cdd:PLN02193 347 YYDPVQDKWTQV----ETF-GVRPSERSVF 371

BACK_KLHL2_like

cd18445

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This ...

178-286

1.98e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This subfamily includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. Both KLHL2 and KLHL3 function as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins.

Pssm-ID: 350520 [Multi-domain] Cd Length: 114 Bit Score: 55.70 E-value: 1.98e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624 178 NCVEVGRIANTYHLTEVDKYVNSFVLKNFAALLSTGEFLKLPFERLAFVLSSNSLKRCTELDLFKATCRWLRLE-EPRMD 256
Cdd:cd18445    5 NCLGIRAFADLHSCTDLLKYAQTYTEQHFSEVVKGEEFLLLSKEQVCELISSDDLTVPSEEKVFEAVMSWVNHDpENRKE 84

                         90       100       110
                 ....*....|....*....|....*....|
gi 755564624 257 VAAKLMKNIRFPLMTPQELINYVQTVDFMR 286
Cdd:cd18445   85 HLAELLEHVRLPLLSPEYLVQRVEEEELIK 114

BTB_POZ_BTBD14B_NAC1

cd18290

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

61-164

2.38e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349599 [Multi-domain] Cd Length: 123 Bit Score: 55.81 E-value: 2.38e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624  61 VLQGFDQLRLDGLLCDVTLMPgdTDDAYPVHRVMMASASDYFKAMFTGgmkeQELMCIKLHG-VSRVGLRKIIDFIYTAK 139
Cdd:cd18290   14 ILECLNEQRLQGLYCDVSVVV--KGHAFKAHRAVLAASSSYFRDLFNS----SRSAVVELPAaVQPQSFQQILSFCYTGR 87

                         90       100
                 ....*....|....*....|....*
gi 755564624 140 LSLNMDTLQDTLEAASFLQILPVLD 164
Cdd:cd18290   88 LSMNVGDQFLLMYTAGFLQIQEIME 112

BTB_POZ_ZBTB48_TZAP_KR3

cd18232

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

57-169

3.14e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349541 [Multi-domain] Cd Length: 108 Bit Score: 54.76 E-value: 3.14e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624  57 HSSVVLQGFDQLRLDGLLCDVTLMPGDTDdaYPVHRVMMASASDYFKAMFTGGMKEQelmcIKLHGVSRVGLRKIIDFIY 136
Cdd:cd18232    1 HSVKVLQALNKQREEGQYCDATLDVGGRV--FKAHWSVLACCSHFFQSLYGDGTSGS----VVLPESFAEVFGLLLDFFY 74

                         90       100       110
                 ....*....|....*....|....*....|...
gi 755564624 137 TAKLSLNMDTLQDTLEAASFLQILPVLDFCKVF 169
Cdd:cd18232   75 TGELALTRENRDRVLLAAKELRVPEAVELCQRF 107

PLN02153

epithiospecifier protein

361-580

3.17e-09

epithiospecifier protein

Pssm-ID: 177814 [Multi-domain] Cd Length: 341 Bit Score: 58.84 E-value: 3.17e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624 361 PRYQHGIAVIGNFLYVVGGQsnydTKGKTAVDT-VFRFDPRYNKW-IQVASLNEKRTF---FHLSALKGFLYAVGGRNAA 435
Cdd:PLN02153  22 PRCSHGIAVVGDKLYSFGGE----LKPNEHIDKdLYVFDFNTHTWsIAPANGDVPRISclgVRMVAVGTKLYIFGGRDEK 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624 436 GELPTVECYNPRTNEWTYVAKMNEPHYGHAGTVYG-----GVMYISGGITHDTFQK------ELMCFDPDTDKWTQ-KAP 503
Cdd:PLN02153  98 REFSDFYSYDTVKNEWTFLTKLDEEGGPEARTFHSmasdeNHVYVFGGVSKGGLMKtperfrTIEAYNIADGKWVQlPDP 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624 504 MTTV--RGLHCMCTVGDRLYVIGGNHFR----GTSDYDDVlSCEYYSPILDQWTPIASMLRGQSDVGV---AVFENKIYV 574
Cdd:PLN02153 178 GENFekRGGAGFAVVQGKIWVVYGFATSilpgGKSDYESN-AVQFFDPASGKWTEVETTGAKPSARSVfahAVVGKYIII 256


                 ....*.
gi 755564624 575 VGGYSW 580
Cdd:PLN02153 257 FGGEVW 262

BACK_calicin

cd18503

BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal ...

176-248

3.91e-09

BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa.

Pssm-ID: 350578 [Multi-domain] Cd Length: 78 Bit Score: 53.51 E-value: 3.91e-09

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755564624 176 LDNCVEVGRIANTYHLTEVDKYVNSFVLKNFAALLSTGEFLKLPFERLAFVLSSNSLKRCTELDLFKATCRWL 248
Cdd:cd18503    3 RDNCLTALCLATTAGLKDLSDEIYDYIRDNFFDVSGTREFLQCPYDIFSRLLKDENLHVNNEDQVLLALLNWT 75

BTB_POZ_roadkill-like

cd18345

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

76-178

3.96e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349654 [Multi-domain] Cd Length: 121 Bit Score: 54.85 E-value: 3.96e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624  76 DVTLMPGDTDdaYPVHRVMMASASDYFKAMFTGGMKEQELMCIKLHGVSRVGLRKIIDFIYTAKLSlNMDTLQDTLEAAS 155
Cdd:cd18345   20 DVTLCVGGRE--FQAHKAILAARSPVFNAMFEHEMEERKQNRVEITDVDHEVMREMLRFIYTGKAP-NLDKMADDLLAAA 96

                         90       100
                 ....*....|....*....|....*.
gi 755564624 156 ---FLQILPVLdfCKVFLISGVTLDN 178
Cdd:cd18345   97 dkyALERLKVM--CEEALCSNLSVEN 120

BACK_KLHL28_BTBD5

cd18467

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also ...

178-271

6.00e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also termed BTB/POZ domain-containing protein 5 (BTBD5), belongs to the KLHL family. Its function remains unclear.

Pssm-ID: 350542 [Multi-domain] Cd Length: 99 Bit Score: 53.80 E-value: 6.00e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624 178 NCVEVGRIANTYHLTEVDKYVNSFVLKNFAALLSTGEFLKLPFERLAFVLSSNSLKRCTELDLFKATCRWLRLE-EPRMD 256
Cdd:cd18467    5 NCIGISRFAETYGCHDLYLAANKYICQNFEDVCQTEEFFELTHAELDEIVSNDCLNVVTEETVFYALESWIKYDvQERQK 84

                         90
                 ....*....|....*
gi 755564624 257 VAAKLMKNIRFPLMT 271
Cdd:cd18467   85 YLAQLLHCVRLPLLS 99

Kelch_1

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

414-458

6.40e-09

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.

Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 51.84 E-value: 6.40e-09

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 755564624  414 RTFFHLSALKGFLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMN 458
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46

BTB_POZ_ZBTB23_GZF1

cd18211

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

54-166

6.90e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349520 [Multi-domain] Cd Length: 128 Bit Score: 54.47 E-value: 6.90e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624  54 SNSHSSVVLQGFDQLRLDGLLCDVTLM---PGDTDDaYPVHRVMMASASDYFKAMFtggMKEQELMC----IKLHGVSRV 126
Cdd:cd18211    5 SKSAPSNLLNEMHKLRLLGHLCDVTVQvehQGSKEE-FSAHKAVLAASSKYFKEVF---LNEKISDGkntnVMLNEIYTA 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 755564624 127 GLRKIIDFIYTAKLSLNMDTLQDTLEAASFLQILPVLDFC 166
Cdd:cd18211   81 DFASFLEFVYTAKVEVEEDRVQRMLEIAEKLKCLDLSETC 120

BTB_POZ_ZBTB10

cd18201

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

55-170

7.78e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349510 [Multi-domain] Cd Length: 122 Bit Score: 54.19 E-value: 7.78e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624  55 NSHSSVVLQGFDQLRLDGLLCDVTLMPgdTDDAYPVHRVMMASASDYFKAMFTGGMKEQ--ELMCIKLHGVSRVGLRKII 132
Cdd:cd18201    2 NSYCYQLLQELNEQRKKGILCDVNIVV--SGKVFRAHKNILVAGSRFFKTLYCFTNKEScdQTTVTHLDVVAVQGFSVIL 79

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 755564624 133 DFIYTAKLSLNMDTLQDTLEAASFLQILPVLDFCKVFL 170
Cdd:cd18201   80 DFMYSGNLVLTSQNAIEVMSVASYLQMTEVVQSCRNFI 117

BACK_KLHL7

cd18447

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a ...

174-269

1.09e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a BTB-Kelch protein that constitutes a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 cause autosomal-dominant retinitis pigmentosa.

Pssm-ID: 350522 [Multi-domain] Cd Length: 98 Bit Score: 53.13 E-value: 1.09e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624 174 VTLDNCVEVGRIANTYHLTEVDKYVNSFVLKNFAALLSTGEFLKLPFERLAFVLSSNSLKRCTELDLFKATCRWLRLEEP 253
Cdd:cd18447    2 VDASNCLGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEP 81

                         90
                 ....*....|....*..
gi 755564624 254 -RMDVAAKLMKNIRFPL 269
Cdd:cd18447   82 nRQPYMVDILAKVRFPL 98

BTB_POZ_ZBTB42

cd18956

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

57-167

1.10e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 42 (ZBTB42); ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. It is enriched in skeletal muscles, especially at the neuromuscular junction. A ZBTB42 mutation has been identified to define a novel lethal congenital contracture syndrome (LCCS6), a lethal autosomal recessive form of arthrogryposis multiplex congenita (AMC). ZBTB42 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349737 [Multi-domain] Cd Length: 129 Bit Score: 54.05 E-value: 1.10e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624  57 HSSVVLQGFDQLRLDGLLCDVTLMPGDTddAYPVHRVMMASASDYFKAMF----TGGMKeqelmCIKLHG--VSRVGLRK 130
Cdd:cd18956    6 HGGRLLGRLRQQRELGFLCDCTVLVGDA--RFPAHRAVLAACSVYFHLFYrdrpAGGRD-----TVRLNGdiVTAPAFGR 78

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 755564624 131 IIDFIYTAKLSLNMDTLQDTLEAASFLQILPVLDFCK 167
Cdd:cd18956   79 LLDFMYEGRLDLRSLPVEDVLAAASYLHMYDIVKVCK 115

BACK_KLHL29_KBTBD9

cd18468

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also ...

178-275

1.17e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also termed Kelch repeat and BTB domain-containing protein 9 (KBTBD9), belongs to the KLHL family. Its function remains unclear. A nuclear receptor subfamily 5, group A, member 2 (NR5A2)-Kelch-like family member 29 (KLHL29) fusion transcript may participate in the origin or progression of some colon cancers.

Pssm-ID: 350543 [Multi-domain] Cd Length: 102 Bit Score: 52.80 E-value: 1.17e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624 178 NCVEVGRIANTYHLTEVDKYVNSFVLKNFAALLSTGEFLKLPFERLAFVLSSNSLKRCTELDLFKATCRWLRLEEP-RMD 256
Cdd:cd18468    4 NCLGIWALAEALQCTELHNMAKAYALQNFPDVARQEEILSISKDDIVEYLSHDSLNTKAEELVFETAIKWLKKDPKnRKQ 83

                         90
                 ....*....|....*....
gi 755564624 257 VAAKLMKNIRFPLMTPQEL 275
Cdd:cd18468   84 HIAELLAVVRLPFIHPSYL 102

BACK_KLHL12

cd18452

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also ...

178-305

1.21e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also termed CUL3-interacting protein 1 (C3IP1), or DKIR, is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport.

Pssm-ID: 350527 [Multi-domain] Cd Length: 136 Bit Score: 53.94 E-value: 1.21e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624 178 NCVEVGRIANTYHLTEVDKYVNSFVLKNFAALLSTGEFLKLPFERLAFVLSSNSLKRCTELDLFKATCRWLRL-EEPRMD 256
Cdd:cd18452    5 NCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFMLLSQEEVEKLIKSDEIQVDSEEPVFEAVLNWVKHdKEERED 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 755564624 257 VAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNLLLEASNYQMMP 305
Cdd:cd18452   85 YLPELLQYVRLPLLSPRYITDVVDAEPLIRCSLECRDLVDEAKKFHLRP 133

BTB1_POZ_KLHL33

cd18262

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

57-157

1.38e-08

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349571 [Multi-domain] Cd Length: 101 Bit Score: 52.60 E-value: 1.38e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624  57 HSSVVLQGFDQLRLDGLLCDVTLMPGDTddAYPVHRVMMASASDYFKAMFTGGmkEQELMciKLHG-VSRVGLRKIIDFI 135
Cdd:cd18262    1 HPSQFFGEAQRLREQRLLLDETVSVGGR--SYGVHSVILAAVSSLFRERLLGS--NGPLP--PLSLeVTPVGWEAVLTFA 74

                         90       100
                 ....*....|....*....|..
gi 755564624 136 YTAKLSLNMDTLQDTLEAASFL 157
Cdd:cd18262   75 YTGVLGRNPATVGDILVAAEAL 96

BTB_POZ_ZBTB34

cd18220

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

52-170

1.55e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34); ZBTB34 acts as a transcriptional regulator. It downregulates specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4 in pancreatic cancer cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349529 [Multi-domain] Cd Length: 120 Bit Score: 53.11 E-value: 1.55e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624  52 FTSNSHSSVVLQGFDQLRLDGLLCDVTLMPgdTDDAYPVHRVMMASASDYFKAMFT-GGMKEQELMCIKLHGVsrvgLRK 130
Cdd:cd18220    3 FDVPEYSNTVLSQLNELRLQGKLCDIIVHI--QGQPFRAHKAVLAASSPYFRDHSAlSTMSGLSISVIKNPNV----FEQ 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 755564624 131 IIDFIYTAKLSLNMDTLQDTLEAASFLQILPVLDFCKVFL 170
Cdd:cd18220   77 LLSFCYTGRMSLQLKDVVSFLTAASFLQMQCVIDKCTQIL 116

Kelch_1

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

361-411

1.61e-08

Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 50.69 E-value: 1.61e-08

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 755564624  361 PRYQHGIAVIGNFLYVVGGQSnydtkGKTAVDTVFRFDPRYNKWIQVASLN 411
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFD-----GNQSLNSVEVYDPETNTWSKLPSMP 46

BTB_POZ_BTBD14A_NAC2

cd18289

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

56-159

1.87e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349598 [Multi-domain] Cd Length: 131 Bit Score: 53.11 E-value: 1.87e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624  56 SHSSVVLQGFDQLRLDGLLCDVTLMPgdTDDAYPVHRVMMASASDYFKAMFTGGMKEQelmcIKLHG-VSRVGLRKIIDF 134
Cdd:cd18289   11 NFGNTVLGCLNEQRLMGLYCDVSIVV--KGQAFKAHRAVLAASSLYFRDLFSGNSKSA----FELPAtVPPACFQQILSF 84

                         90       100
                 ....*....|....*....|....*
gi 755564624 135 IYTAKLSLNMDTLQDTLEAASFLQI 159
Cdd:cd18289   85 CYTGKLTMAASEQLVVMYTAGFLQI 109

BACK_KLHL5

cd18511

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares ...

178-275

2.01e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. It is abundantly expressed in ovary, adrenal gland, and thymus.

Pssm-ID: 350586 [Multi-domain] Cd Length: 106 Bit Score: 52.38 E-value: 2.01e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624 178 NCVEVGRIANTYHLTEVDKYVNSFVLKNFAALLSTGEFLKLPFERLAFVLSSNSLKRCTELDLFKATCRWLRLE-EPRMD 256
Cdd:cd18511    6 NCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFLLLPASEIAKLLASDDMNIPNEETILNALLSWVRHDvEQRRK 85

                         90
                 ....*....|....*....
gi 755564624 257 VAAKLMKNIRFPLMTPQEL 275
Cdd:cd18511   86 DLSKLLAYIRLPLLAPQFL 104

BTB_POZ_KBTBD11

cd18275

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

91-182

3.07e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11 is also called chronic myelogenous leukemia-associated protein (CMLAP) or Kelch domain-containing protein 7B, or KLHDC7C. It is a BTB-Kelch family protein whose function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349584 [Multi-domain] Cd Length: 104 Bit Score: 51.72 E-value: 3.07e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624  91 HRVMMASASDYFKAMFTGGMkeqelmcIKLHGVSRVGLRKIIDFIYTAKLSLNMDTLQDTLEAASFLQiLPVLDFCKVFL 170
Cdd:cd18275   19 HKSVLAAKSDYFRARLSRDI-------LKVKGLSYATLRLLVDYVYSGRMAVSKDNVVEVVAGARFLQ-MPCAAQCAVDA 90

                         90
                 ....*....|...
gi 755564624 171 ISG-VTLDNCVEV 182
Cdd:cd18275   91 VRAqLCLGNCYEV 103

BTB_POZ_ZBTB29-like

cd18216

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

56-167

3.42e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349525 [Multi-domain] Cd Length: 118 Bit Score: 52.15 E-value: 3.42e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624  56 SHSSVVLQGFDQLRLDGLLCDVTLMPGDTddAYPVHRVMMASASDYFKAMftggMKEQELMCIKLHGVSRVGLRKIIDFI 135
Cdd:cd18216    2 SHATQLLLQLNNQRTKGFLCDVIIVVENS--LFRAHKNVLAASSGYFKSL----VLHDNLIHLDQDMVSPTVFQQILDFI 75

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 755564624 136 YTAKLS---LNMDTLQDTLEAASFLQILPVLDFCK 167
Cdd:cd18216   76 YTGKLLdslFEEPNLSEVLAAANYLQLPDLAALCR 110

BTB_POZ_ZBTB38_CIBZ

cd18223

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

57-160

4.32e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349532 [Multi-domain] Cd Length: 114 Bit Score: 51.71 E-value: 4.32e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624  57 HSSVVLQGFDQLRLDGLLCDVTLMPGDTDdaYPVHRVMMASASDYFKAMFTggmkEQELmCIKLHGVSRVGLR-----KI 131
Cdd:cd18223    1 HSDTVLSCLNEQRIQGILCDVTIVVEDTK--FKAHKNVLAASSLYFKNAFS----SQEI-WISSHVLELPDLKaevfaEI 73

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 755564624 132 IDFIYTAKLSL-NMDTLQDTLEAA-----SFLQIL 160
Cdd:cd18223   74 LNFIYSSKVVVkRQETVTDLVAAGkklgiTFLENL 108

BTB_POZ_ZBTB32_FAZF_TZFP

cd18218

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

57-166

4.47e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 32 (ZBTB32); ZBTB32 is also called FANCC-interacting protein, fanconi anemia zinc finger protein (FAZF), testis zinc finger protein (TZFP), or zinc finger protein 538 (ZNF538). It is a DNA-binding transcription factor that binds to the 5'-TGTACAGTGT-3' core sequence. It acts as a transcription suppressor that controls T cell-mediated autoimmunity. ZBTB32 is essential for down-regulation of GATA3 via ZPO2; this promotes aggressive breast cancer development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349527 [Multi-domain] Cd Length: 110 Bit Score: 51.48 E-value: 4.47e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624  57 HSSVVLQGFDQLRLDGLLCDVTLMPGDTDdaYPVHRVMMASASDYFKAMFTGGMKEQelmCIKLHGVSRVGLRKIIDFIY 136
Cdd:cd18218    1 HSDRLLHLAARLRPAGALCDTLITVGSQE--FPAHSLVLAGASQQLGRQLTNPNPGQ---WCLGEGISPSTFKQLLDFVY 75

                         90       100       110
                 ....*....|....*....|....*....|
gi 755564624 137 TAKLSLNMDTLQDTLEAASFLQILPVLDFC 166
Cdd:cd18218   76 GESVEVQPGELRPLLEAARALEVESLEEAC 105

BTB_POZ_ZBTB45

cd18229

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

58-166

6.01e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45); ZBTB45, also called zinc finger protein 499 (ZNF499), may act as a transcriptional regulator that is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349538 [Multi-domain] Cd Length: 112 Bit Score: 51.40 E-value: 6.01e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624  58 SSVVLQGFDQLRLDGLLCDVTLMPGDTddAYPVHRVMMASASDYFKAMFTGGMKEQELMCIklhgVSRVGLRKIIDFIYT 137
Cdd:cd18229    2 SKSLLETLNAQRLGGHFCDVTVRIHDA--SLRAHRCVLAAGSPFFHDKLLLGHSEIEVPPV----VPAQTVRQLVEFMYS 75

                         90       100
                 ....*....|....*....|....*....
gi 755564624 138 AKLSLNMDTLQDTLEAASFLQILPVLDFC 166
Cdd:cd18229   76 GSLVVAQSEALQILTAASILQIKTVIDEC 104

BTB_POZ_ZBTB29_HIC1

cd18333

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

56-167

7.12e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1); Hic-1, also called zinc finger and BTB domain-containing protein 29 (ZBTB29), is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. It may act as a tumor suppressor, and is involved in regulatory loops modulating P53-dependent and E2F1-dependent cell survival, growth control, and stress responses. It also regulates intestinal immunity and homeostasis. Hic-1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349642 [Multi-domain] Cd Length: 121 Bit Score: 51.44 E-value: 7.12e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624  56 SHSSVVLQGFDQLRLDGLLCDVTLMPGDTddAYPVHRVMMASASDYFKAMFTggmkEQELMCIKLHGVSRVGLRKIIDFI 135
Cdd:cd18333    3 SHSRQLLLQLNTQRTKGFLCDVIIVVQNA--LFRAHKNILAASSVYLKSLVV----HDNLINLDHEMVSPGIFRLILDYI 76

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 755564624 136 YTAKLS----LNMDTLQDTLEAASFLQILPVLDFCK 167
Cdd:cd18333   77 YTGRLSegdpGSEQNLGAVLAAASYLQIPDLVALCK 112

BTB_POZ_ARIA_plant

cd18352

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...

74-178

7.23e-08

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349661 [Multi-domain] Cd Length: 116 Bit Score: 51.32 E-value: 7.23e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624  74 LCDVT-LMPGDTddaYPVHRVMMASASDYFKAMFTGGMKEQELMCIKLHGVSRVGLRKIIDFIYTAKLSLNMDTLQDTLE 152
Cdd:cd18352   13 LSDVTfLVEGRR---FYAHRIALLASSDAFRAMFDGGYREKEARDIEIPNIRWEVFELMMRFIYTGSVDITNDIAKDLLR 89

                         90       100
                 ....*....|....*....|....*.
gi 755564624 153 AASFLQILPVLDFCKVFLISGVTLDN 178
Cdd:cd18352   90 AADQYLLEGLKRLCEYTIAQDLTLEN 115

Kelch_1

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

561-602

7.78e-08

Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 48.76 E-value: 7.78e-08

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 755564624  561 SDVGVAVFENKIYVVGGYSWNNRcmVEIVQKYDPEKNEWHKV 602
Cdd:pfam01344   3 SGAGVVVVGGKIYVIGGFDGNQS--LNSVEVYDPETNTWSKL 42

BTB2_POZ_ABTB1_BPOZ1

cd18296

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

88-163

8.43e-08

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349605 [Multi-domain] Cd Length: 121 Bit Score: 51.14 E-value: 8.43e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624  88 YPVHRVMMASASDYFKAMFTGGMKE-----QELMCIKLHGVSRVGLRKIIDFIYTAKLSLNMDTLQDTLEAASFLqILPV 162
Cdd:cd18296   29 FPCHKAFFCGRSDYFKALLRDHFAEseennGSIPVVTLHDVSPEVFAIVLYYIYTDDTDLPPENAYDVLYVADMY-LLPG 107


                 .
gi 755564624 163 L 163
Cdd:cd18296  108 L 108

BACK_KLHL16_gigaxonin

cd18455

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, ...

175-252

9.26e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, also termed Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy.

Pssm-ID: 350530 [Multi-domain] Cd Length: 97 Bit Score: 50.39 E-value: 9.26e-08

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755564624 175 TLDNCVEVGRIANTYHLTEVDKYVNSFVLKNFAALLSTGEFLKLPFERLAFVLSSNSLKRCTELDLFKATCRWLRLEE 252
Cdd:cd18455    1 SAENCIGIRDFAERFSCPHVHYVATEYLETHFRDVSSTEEFLELSPEKLKELLSRDKLNVGNEEYIFEAVLRWVRHDP 78

BTB_POZ_ZBTB35_ZNF131

cd18221

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

57-160

1.22e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349530 [Multi-domain] Cd Length: 113 Bit Score: 50.38 E-value: 1.22e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624  57 HSSVVLQGFDQLRLDGLLCDVTLMPgdTDDAYPVHRVMMASASDYFKAMFTGGMKEQelmCIKLHGVSRVGLRKIIDFIY 136
Cdd:cd18221    1 HYKVMLDRLNEQRELDQFTDITLIV--DGHQFKAHKAVLAACSQFFYKFFQDFTQEP---LVEIEGVSNMAFRHLIEFTY 75

                         90       100
                 ....*....|....*....|....*
gi 755564624 137 TAKLSLN-MDTLQDTLEAASFLQIL 160
Cdd:cd18221   76 TAKLMVQgEEEANDVWKAAEYLQMQ 100

BACK_KLHL17

cd18456

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also ...

178-271

1.35e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also termed actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GluR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in the actin-based neuronal function.

Pssm-ID: 350531 [Multi-domain] Cd Length: 102 Bit Score: 50.00 E-value: 1.35e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624 178 NCVEVGRIANTYHLTEVDKYVNSFVLKNFAALLSTGEFLKLPFERLAFVLSSNSLKRCTELDLFKATCRWLRLE-EPRMD 256
Cdd:cd18456    5 NCLGIRGFADTHSCSDLLKSAHKYVLQHFVEVSKTEEFMLLPLKQVLDLISSDSLNVPSEEEVYRAVLSWVKHDvDGRRQ 84

                         90
                 ....*....|....*
gi 755564624 257 VAAKLMKNIRFPLMT 271
Cdd:cd18456   85 HVPRLMKCVRLPLLS 99

Kelch

Kelch domain;

374-424

1.39e-07

Kelch domain;

Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 48.32 E-value: 1.39e-07

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 755564624   374 LYVVGGQSnydtkGKTAVDTVFRFDPRYNKWIQVASLNEKRTFFHLSALKG 424
Cdd:smart00612   2 IYVVGGFD-----GGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47

Kelch

Kelch domain;

519-570

1.44e-07

Kelch domain;

Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 47.94 E-value: 1.44e-07

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 755564624   519 RLYVIGGNHFRGTSDyddvlSCEYYSPILDQWTPIASMLRGQSDVGVAVFEN 570
Cdd:smart00612   1 KIYVVGGFDGGQRLK-----SVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47

BTB_POZ_ZBTB27_BCL6

cd18331

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

57-170

1.61e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349640 [Multi-domain] Cd Length: 118 Bit Score: 50.24 E-value: 1.61e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624  57 HSSVVLQGFDQLRLDGLLCDVTLMPgdTDDAYPVHRVMMASASDYFKAMFTGGMKeQELMCIKLH-GVSRVGLRKIIDFI 135
Cdd:cd18331    7 HASDVLLNLNRLRSRDILTDVVIVV--SREQFRAHKTVLMACSGLFYSIFTDQLK-CNLSVINLDpEINPEGFNILLDFM 83

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 755564624 136 YTAKLSLNMDTLQDTLEAASFLQILPVLDFCKVFL 170
Cdd:cd18331   84 YTSRLNLREGNIMAVMATAMYLQMEHVVDTCRKFI 118

BACK_KLHL1

cd18509

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a ...

178-275

1.68e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton in brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.

Pssm-ID: 350584 [Multi-domain] Cd Length: 106 Bit Score: 50.02 E-value: 1.68e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624 178 NCVEVGRIANTYHLTEVDKYVNSFVLKNFAALLSTGEFLKLPFERLAFVLSSNSLKRCTELDLFKATCRWLRLE-EPRMD 256
Cdd:cd18509    6 NCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDmQRRCS 85

                         90
                 ....*....|....*....
gi 755564624 257 VAAKLMKNIRFPLMTPQEL 275
Cdd:cd18509   86 DLSMLLAYIRLPLLPPQLL 104

Kelch_1

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

460-505

1.90e-07

Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 47.61 E-value: 1.90e-07

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 755564624  460 PHYGHAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWTQKAPMT 505
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46

Kelch

Kelch domain;

472-518

2.08e-07

Kelch domain;

Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 47.55 E-value: 2.08e-07

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 755564624   472 VMYISGGITHDTFQKELMCFDPDTDKWTQKAPMTTVRGLHCMCTVGD 518
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47

BTB_POZ_ETO1-like

cd18190

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...

92-155

2.10e-07

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana ethylene-overproduction protein 1 (ETO1) and similar proteins; ETO1, also called protein ethylene overproducer 1, is an essential regulator of the ethylene pathway, which acts by regulating the stability of 1-aminocyclopropane-1-carboxylate synthase (ACS) enzymes. It may act as a substrate-specific adaptor that connects ACS enzymes, such as ACS5, to ubiquitin ligase complexes, leading to proteasomal degradation of ACS enzymes. The family also includes ETO1-like proteins 1 (EOL1) and 2 (EOL2). ETO1, EOL1, and EOL2 contain a BTB domain and tetratricopeptide (TPR) repeats. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349499 [Multi-domain] Cd Length: 83 Bit Score: 48.67 E-value: 2.10e-07

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755564624  92 RVMMASASDYFKAMFTGGMKEQELMCIKL--HGVSRVGLRKIIDFIYTAKLSL-NMDTLQDTLEAAS 155
Cdd:cd18190   15 RKKIASLSRPFKAMLYGNFRESTSDCIDFeeNGISIEAMRAVIDFSVTGRLDLfSVENVHEVLELAS 81

BTB_POZ_BPM_plant

cd18280

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

63-155

2.28e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349589 [Multi-domain] Cd Length: 121 Bit Score: 50.02 E-value: 2.28e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624  63 QGFDQLRLDGLLCDVTLMPGDtdDAYPVHRVMMASASDYFKAMFTGGMKEQELMCIKLHGVSRVGLRKIIDFIYTaklsl 142
Cdd:cd18280    3 QHFGALLESEEGADVTFNVDG--EKFRAHKLVLAARSPVFRSMLFGPMREENEGEIVIEDVEPPVFKALLHFIYK----- 75

                         90
                 ....*....|...
gi 755564624 143 nmDTLQDTLEAAS 155
Cdd:cd18280   76 --DELPDDVEPAG 86

BTB_POZ_ZBTB8B

cd18330

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

88-170

2.29e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349639 [Multi-domain] Cd Length: 113 Bit Score: 49.54 E-value: 2.29e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624  88 YPVHRVMMASASDYFKAMFTGGMKE-QELMCIKLHGVSRVGLRKIIDFIYTAKLSLNMDTLQDTLEAASFLQILPVLDFC 166
Cdd:cd18330   30 FKAHRNILFANSGYFRALLIHYIQDsGRHSTASLDIVTSEAFSIILDFLYSGKLDLCSENVIEVMSAASYLQMTDVVNFC 109


                 ....
gi 755564624 167 KVFL 170
Cdd:cd18330  110 KGYI 113

BTB_POZ_ZBTB20_DPZF

cd18208

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

58-166

3.14e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20); ZBTB20, also called dendritic-derived BTB/POZ zinc finger protein (DPZF) or zinc finger protein 288, may be a transcription factor involved in hematopoiesis, oncogenesis, and immune responses. It is an essential regulator of hepatic lipogenesis and may be a therapeutic target for the treatment of fatty liver disease. It also functions as a critical regulator of anterior pituitary development and lactotrope specification. Moreover, it promotes astrocytogenesis during neocortical development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349517 [Multi-domain] Cd Length: 117 Bit Score: 49.29 E-value: 3.14e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624  58 SSVVLQGFDQLRLDGLLCDVTL-MPGDTDDAypvHRVMMASASDYFKAMFTGGMKEQELMCIklhgVSRVGLRKIIDFIY 136
Cdd:cd18208    9 SNSVLETLNEQRNRGHFCDVTVrIHGSMLRA---HRCVLAAGSPFFQDKLLLGYSDIEIPSV----VSVQSVQKLIDFMY 81

                         90       100       110
                 ....*....|....*....|....*....|
gi 755564624 137 TAKLSLNMDTLQDTLEAASFLQILPVLDFC 166
Cdd:cd18208   82 SGVLRVSQSEALQILTAASILQIKTVIDEC 111

BACK_KLHL4

cd18510

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares ...

178-275

3.47e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.

Pssm-ID: 350585 [Multi-domain] Cd Length: 106 Bit Score: 48.76 E-value: 3.47e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624 178 NCVEVGRIANTYHLTEVDKYVNSFVLKNFAALLSTGEFLKLPFERLAFVLSSNSLKRCTELDLFKATCRWLRLE-EPRMD 256
Cdd:cd18510    6 NCLGIRSFGDAQGCTELLKVAHSYTMEHFLEVIKNQEFLLLPASEIVKLLASDDINVPDEETIFQALMMWVRHDlQNRQK 85

                         90
                 ....*....|....*....
gi 755564624 257 VAAKLMKNIRFPLMTPQEL 275
Cdd:cd18510   86 DLGMLLSYIRLPLLPPQLL 104

BACK_KLHL33

cd18472

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs ...

174-248

3.52e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs to the KLHL family. Its function remains unclear. KLHL33 SNPs may be associated with prostate cancer risk.

Pssm-ID: 350547 [Multi-domain] Cd Length: 75 Bit Score: 47.77 E-value: 3.52e-07

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755564624 174 VTLDNCVEVGRIANTYHLTEVDKYVNSFVLKNFAALLSTGEFLKLPFERLAFVLSSNSLKRCTELDLFKATCRWL 248
Cdd:cd18472    1 LSPANCLELWAFADAATLPRLAAAARAFALKHFAEVAASAAFLSLPLARLLELLRSDELEVAEEEAVFEAAVRWL 75

BTB1_POZ_RhoBTB

cd18299

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

63-170

3.68e-07

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349608 [Multi-domain] Cd Length: 103 Bit Score: 48.75 E-value: 3.68e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624  63 QGFDQLRLDGLLCDVTLMpGDTDDAYPVHRVMMASASDYFKAMFTggmkeqeLMC-IKLHG-VSRVGLRKIIDFIYTAKL 140
Cdd:cd18299    1 EDLRNLLHSPSCADVVFI-LQGGVRIFAHRIVLAAASSVFADLFL-------MMTvVTLDSdITPEAFRRVLEFLYTGVL 72

                         90       100       110
                 ....*....|....*....|....*....|
gi 755564624 141 SLNMDTLQDTLEAASFLQILPVLDFCKVFL 170
Cdd:cd18299   73 DENEDDLKELKDAAELLELFDLVMMCTNVL 102

Kelch_1

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

508-556

3.88e-07

Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 46.84 E-value: 3.88e-07

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 755564624  508 RGLHCMCTVGDRLYVIGGnhFRGTSDYDDVlscEYYSPILDQWTPIASM 556
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGG--FDGNQSLNSV---EVYDPETNTWSKLPSM 45

BTB_POZ_ZBTB9

cd18200

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

57-170

4.67e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 9 (ZBTB9); ZBTB9 may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349509 [Multi-domain] Cd Length: 111 Bit Score: 48.70 E-value: 4.67e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624  57 HSSVVLQGFDQLRLDGLLCDVTLMPgdTDDAYPVHRVMMASASDYFKAMFTGGmkeqELMCIKLHGVSRV-GLRKIIDFI 135
Cdd:cd18200    1 YSSALLETLNKHRLEGKFCDLSVHV--QGRVFRAHKAVLAASSPYFHDKLLLN----DTNCLVLPSVIEAaAFENLLQLI 74

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 755564624 136 YTAKLSLNMDTLQDTLEAASFLQILPVLDFCKVFL 170
Cdd:cd18200   75 YSGRLTLCMDALPSHLLVASGLQMWQVVDRCSELL 109

BACK_KLHL30

cd18469

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs ...

178-273

7.38e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs to the KLHL family. Its function remains unclear. Differential expression of the KLHL30 gene has been observed in glioblastoma multiforme versus normal brain.

Pssm-ID: 350544 [Multi-domain] Cd Length: 104 Bit Score: 47.83 E-value: 7.38e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624 178 NCVEVGRIANTYHLTEVDKYVNSFVLKNFAALLSTGEFLKLPFERLAFVLSSNSLKRCTELDLFKATCRWLRLEEP-RMD 256
Cdd:cd18469    7 NCLGICEFGETHGCPEVAAKAWSFLLENFEAVSQEEEFLQLEKERLVACLGDDLLQVRDEQSRLEAVLRWVGHDPQaRAA 86

                         90
                 ....*....|....*..
gi 755564624 257 VAAKLMKNIRFPLMTPQ 273
Cdd:cd18469   87 HLPELLSLVHLSLLTDQ 103

Kelch_6

pfam13964

Kelch motif;

361-414

7.72e-07

Kelch motif;

Pssm-ID: 404790 [Multi-domain] Cd Length: 50 Bit Score: 46.17 E-value: 7.72e-07

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 755564624  361 PRYQHGIAVIGNFLYVVGGQSNYDtkgkTAVDTVFRFDPRYNKWIQVASLNEKR 414
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYTNAS----PALNKLEVYNPLTKSWEELPPLPTPR 50

BTB_POZ_ZBTB21_ZNF295

cd18209

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

57-140

7.88e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21); ZBTB21, also called zinc finger protein 295 (ZNF295), is a transcription repressor that acts in a selective manner on different promoters. It may be involved in the bi-directional control of gene expression in concert with another transcription factor ZFP161. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349518 [Multi-domain] Cd Length: 112 Bit Score: 47.95 E-value: 7.88e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624  57 HSSVVLQGFDQLRLDGLLCDVTLMPGdtDDAYPVHRVMMASASDYFKAMFTGGMKEQELMcIKLHGVSRVGLRKIIDFIY 136
Cdd:cd18209    1 HAISLLSALNEERLKGQLCDVLLIVG--DQKFRAHKNVLAASSEYFQSLFTEKENESQSV-FQLDFCEPDAFENVLNYIY 77


                 ....
gi 755564624 137 TAKL 140
Cdd:cd18209   78 SSSL 81

BTB_POZ_BTBD19

cd18294

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

73-154

1.26e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349603 [Multi-domain] Cd Length: 111 Bit Score: 47.24 E-value: 1.26e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624  73 LLCDVTLMPGDtdDAYPV--HRVMMASASDYFKAMF-TGGMKEQELMCIKLHGVSRVGLRKIIDFIYTAKLSLNMDTLQD 149
Cdd:cd18294   13 EFSDVKFLVGP--ERQEIfaHKCILAARCEVFRAMFlTGPQKESTQSPLVLSDIEPEVFRAVLEFIYTNCVTLSNHTVIE 90


                 ....*
gi 755564624 150 TLEAA 154
Cdd:cd18294   91 VLAAA 95

BACK_KLHL32_BKLHD5

cd18471

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also ...

178-270

1.29e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also termed BTB and kelch domain-containing protein 5 (BKLHD5), belongs to the KLHL family. Its function remains unclear. KLHL32 SNPs may be associated with body mass index in individuals of African ancestry.

Pssm-ID: 350546 [Multi-domain] Cd Length: 98 Bit Score: 47.21 E-value: 1.29e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624 178 NCVEVGRIANTYHLTEVDKYVNSFVLKNFAALLST--GEFLKLPFERLAFVLSSNSLKRCTELDLFKATCRWLRlEEPRM 255
Cdd:cd18471    5 NYLDLYKLADLFNLTLLEEAVVDFLVKHLSELLKShpEEVLALPYRLLREVLKSDRLTSLSEEQIWQLAVRWLE-HNCRY 83

                         90
                 ....*....|....*
gi 755564624 256 DVAAKLMKNIRFPLM 270
Cdd:cd18471   84 QYMDELLQYVRFGLM 98

BTB_POZ_calicin

cd18307

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

75-169

1.39e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349616 [Multi-domain] Cd Length: 97 Bit Score: 47.11 E-value: 1.39e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624  75 CDVTLMPGDTddAYPVHRVMMASASDYFKAMFTGGM--KEQEL-MCIKLHGVSRVGLRKIIDFIYTAKLSLNMDTLQDTL 151
Cdd:cd18307    2 CDVVISVDNH--SFAAHRNVLAAVSPFVKSLISSNDmkATDELsITIDCDYLSPETVEQLLDYFYTGKIVISEKNVEDLL 79

                         90
                 ....*....|....*...
gi 755564624 152 EAASFLQILPVLDFCKVF 169
Cdd:cd18307   80 KGAKYFNIPRLKDHCVDF 97

BTB_POZ_SPOP-like

cd18279

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

76-178

1.68e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349588 [Multi-domain] Cd Length: 120 Bit Score: 47.52 E-value: 1.68e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624  76 DVTLMPGDTDdaYPVHRVMMASASDYFKAMFTGGMKEQELMCIKLHGVSRVGLRKIIDFIYTAKlSLNMDTLQDTLEAAS 155
Cdd:cd18279   20 DCCLCVGGQE--FQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTGK-APNLDKMADDLLAAA 96

                         90       100
                 ....*....|....*....|....*.
gi 755564624 156 ---FLQILPVLdfCKVFLISGVTLDN 178
Cdd:cd18279   97 dkyALERLKVM--CEDALCSNLSVEN 120

BTB2_POZ_BTBD8

cd18286

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

67-142

1.69e-06

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349595 [Multi-domain] Cd Length: 121 Bit Score: 47.25 E-value: 1.69e-06

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755564624  67 QLRLDGLLCDVTLMPGDTDdaYPVHRVMMASASDYFKAMFTGGMKEQELMCIKLHGVSRVGLRKIIDFIYTAKLSL 142
Cdd:cd18286   10 QLFLNGEDSDITIKVDGKT--FKAHRCILCARSSYFAAMLSGSWAESNSSEITLTGVSHAAVSFVLLFIYGGVLDL 83

BTB_POZ_KBTBD13

cd18320

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

88-158

2.84e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 13 (KBTBD13); KBTBD13 is a muscle specific protein. Its autosomal dominant mutations may cause Nemaline Myopathy (NEM). KBTBD13 may act as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that functions as a muscle specific ubiquitin ligase, and thereby implicating the ubiquitin proteasome pathway in the pathogenesis of KBTBD13-associated NEM. KBTBD13 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349629 [Multi-domain] Cd Length: 83 Bit Score: 45.49 E-value: 2.84e-06

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755564624  88 YPVHRVMMASASDYFKAMFTGGMKEQELMCIKLHGVSRVGLRKIIDFIYTAKLSLNMDTLQDTLEAASFLQ 158
Cdd:cd18320   13 FTVDKALLVENSEYFRALFRSGMRECTQDEIRLQGLSARGFRIMLRVLAGERPILNGEEILQAIECAAFLQ 83

BTB_POZ_CP190-like

cd18311

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...

62-163

3.13e-06

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster centrosomal protein 190kD (CP190) and similar proteins; CP190 is a large, multi-domain protein, first identified as a centrosome protein with oscillatory localization over the course of the cell cycle. It has an essential function in the nucleus as a chromatin insulator. It is known to associate with the nuclear matrix, components of the RNAi machinery, active promoters and borders of the repressive chromatin domains. CP190 contains an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349620 [Multi-domain] Cd Length: 110 Bit Score: 46.42 E-value: 3.13e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624  62 LQGFDQLRLDGLLCDVTLMpGDTDDAYPVHRVMMASASDYFKAMFTGGMKEQELMCIKLHgVSRVGLRKIIDFIYTAKLS 141
Cdd:cd18311    2 LQRLQNLFNKTEYCDLTLQ-FRDNEQLKVHRLVLSACTDYFNVLEQTCEIVDDTLIMPNE-LQADAVVPVINFMYTGQLE 79

                         90       100
                 ....*....|....*....|..
gi 755564624 142 LNMDTLQDTLEAASFLQILPVL 163
Cdd:cd18311   80 FEEKSYGKLLRTAKELNMTVLL 101

BTB_POZ_ZBTB6

cd18197

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

52-166

3.17e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 6 (ZBTB6); ZBTB6, also called zinc finger protein 482 (ZNF482) or zinc finger protein with interaction domain, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349506 [Multi-domain] Cd Length: 116 Bit Score: 46.40 E-value: 3.17e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624  52 FTSNSHSSVVLQGFDQLRLDGLLCDVTLMPGDTddAYPVHRVMMASASDYFKAMFTggMKEQELMCIKLHGVSRVGlRKI 131
Cdd:cd18197    3 FKFEQQGDAVLQKMNLLRQQNLFCDVSIYINDT--EFHGHKVILAACSTFMRDQFL--LNQSKQVRITILQSAEVG-RKL 77

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 755564624 132 IDFIYTAKLSLNMDTLQDTLEAASFLQILPVLDFC 166
Cdd:cd18197   78 LLSCYTGALEVKKKELLKYLTAASYLQMVHIVEKC 112

BTB_POZ_ZBTB26_Bioref

cd18214

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

52-166

3.48e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 26 (ZBTB26); ZBTB26, also called zinc finger protein 481 (ZNF481) or zinc finger protein Bioref, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349523 [Multi-domain] Cd Length: 122 Bit Score: 46.36 E-value: 3.48e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624  52 FTSNSHSSVVLQGFDQLRLDGLLCDVTLMPGDTDdaYPVHRVMMASASDYFKAMFTggMKEQELMCIKLHGVSRVGlRKI 131
Cdd:cd18214    3 FRFENYGDSMLQKMNKLREQNKFCDVTVHIDDLE--VPGHKVVFAAGSPFLRDQFL--LNDSREVQISILQNSEVG-RQL 77

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 755564624 132 IDFIYTAKLSLNMDTLQDTLEAASFLQILPVLDFC 166
Cdd:cd18214   78 LLSCYTGVLEFPEMELVNYLTAASFLQMSHIVERC 112

BACK_KLHL20

cd18459

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also ...

178-271

3.49e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also termed Kelch-like ECT2-interacting protein (KLEIP), or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis.

Pssm-ID: 350534 [Multi-domain] Cd Length: 100 Bit Score: 45.88 E-value: 3.49e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624 178 NCVEVGRIANTYHLTEVDKYVNSFVLKNFAALLSTGEFLKLPFERLAFVLSSNSLKRCTELDLFKATCRWLRLEEP-RMD 256
Cdd:cd18459    6 NCLGIRAFADTHACRELLRIADKFTQHNFQEVMESEEFMLLPVNQLIDIISSDELNVRSEEQVFNAVMAWVKYNIQeRRP 85

                         90
                 ....*....|....*
gi 755564624 257 VAAKLMKNIRFPLMT 271
Cdd:cd18459   86 HLPQVLQHVRLPLLS 100

Kelch

Kelch domain;

571-617

3.57e-06

Kelch domain;

Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 44.09 E-value: 3.57e-06

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 755564624   571 KIYVVGGYSWNNRC-MVEIvqkYDPEKNEWHKVFDLPESLGGIRACTL 617
Cdd:smart00612   1 KIYVVGGFDGGQRLkSVEV---YDPETNKWTPLPSMPTPRSGHGVAVI 45

BACK_KLHL24

cd18463

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also ...

178-249

5.38e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6), or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of the BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation.

Pssm-ID: 350538 [Multi-domain] Cd Length: 78 Bit Score: 44.69 E-value: 5.38e-06

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755564624 178 NCVEVGRIANTYHLTEVDKYVNSFVLKNFAALLSTGEFLKLPFERLAFVLSSNSLKRCTELDLFKATCRWLR 249
Cdd:cd18463    6 NCLGIQKFADTHSLKQLFEKCKKFALENFVEVSQHEEFLELCKDELIEYISNDELVVPKEEEVFEAVMRWVY 77

BTB_POZ_ZBTB22_BING1

cd18210

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

58-170

5.95e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22); ZBTB22, also called protein BING1 or zinc finger protein 297, may be involved in transcriptional regulation. Its gene, together with BING 3-5, TAPASIN, DAXX, RGL2, and HKE2, form a dense cluster at the centromeric end of the major histocompatibility complex class I region. ZBTB22 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349519 [Multi-domain] Cd Length: 112 Bit Score: 45.60 E-value: 5.95e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624  58 SSVVLQGFDQLRLDGLLCDVTL-MPGDTddaYPVHRVMMASASDYFKamftggmkEQELmcikLHGVSRVGLRKIID--- 133
Cdd:cd18210    5 TSSLLESLNQQRMEGKLCDISIhVQGRV---FRAHRAVLAASSPYFH--------DQVL----LKNMSSISLPGVMDpga 69

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 755564624 134 ------FIYTAKLSLNMDTLQDTLEAASFLQILPVLDFCKVFL 170
Cdd:cd18210   70 fesvlaSAYTGKLTMLADEIVNYLTVGSVLQMWHIVDKCTELL 112

BTB_POZ_ZBTB39

cd18224

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

54-166

6.02e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39); ZBTB39 may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349533 [Multi-domain] Cd Length: 123 Bit Score: 45.98 E-value: 6.02e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624  54 SNSHSSVVLQGFDQLRLDGLLCDVTLMPGDTddAYPVHRVMMASASDYFKAMF--TGGMKEQELMcikLHGVSRVGLRKI 131
Cdd:cd18224    6 SSDHPNNLLKELNKCRLSETMCDVTIVVGNR--SFAAHKAVLACAAGYFQKLFlsTELDVARTYV---VDFITPANFEKV 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 755564624 132 IDFIYTAKLSLNMDTLQDTLEAASFLQILPVLDFC 166
Cdd:cd18224   81 LSFIYTSELFTDLINVGVIYEVAEKLGMEDLLKAC 115

PRK14131

N-acetylneuraminate epimerase;

351-504

8.31e-06

N-acetylneuraminate epimerase;

Pssm-ID: 237617 [Multi-domain] Cd Length: 376 Bit Score: 48.47 E-value: 8.31e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624 351 EWKSLAPM-DAPRYQHGIAVIGNFLYVVGGQSNYDTKGKT-AVDTVFRFDPRYNKWIQVASlnekRTFFHLSALKGF--- 425
Cdd:PRK14131  63 GWTKIAAFpGGPREQAVAAFIDGKLYVFGGIGKTNSEGSPqVFDDVYKYDPKTNSWQKLDT----RSPVGLAGHVAVslh 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624 426 ---LYAVGGRN------------AAGELPTVE----------------------CYNPRTNEWTYVAKMnePHYGHAG-- 466
Cdd:PRK14131 139 ngkAYITGGVNknifdgyfedlaAAGKDKTPKdkindayfdkkpedyffnkevlSYDPSTNQWKNAGES--PFLGTAGsa 216

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 755564624 467 TVYGG--VMYISGGI-----THDTFQKElmcFDPDTDKWTQKAPM 504
Cdd:PRK14131 217 VVIKGnkLWLINGEIkpglrTDAVKQGK---FTGNNLKWQKLPDL 258

BTB_POZ_ZBTB1

cd18192

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

56-159

8.61e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1); ZBTB1 acts as a transcriptional repressor that represses cAMP-responsive element (CRE)-mediated transcriptional activation. It also has a role in translesion DNA synthesis, and is essential for lymphocyte development. ZBTB1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349501 [Multi-domain] Cd Length: 114 Bit Score: 45.20 E-value: 8.61e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624  56 SHSSVVLQGFDQLRLDGLLCDVTLMPGDTddAYPVHRVMMASASDYFKAMFtggMKEQelmciklHGVSRVGLRK----- 130
Cdd:cd18192    3 SHSSYVLQQLNNQREWGFLCDCCIAIDDI--YFQAHKAVLAACSSYFRMMF---INHQ-------HTTAQLNLSNmkisa 70

                         90       100       110
                 ....*....|....*....|....*....|....
gi 755564624 131 -----IIDFIYTAKLSLNMDTLQDTLEAASFLQI 159
Cdd:cd18192   71 ecfdlILQFMYLGKIMTAPSDFEQLKVAMNYLQL 104

BTB_POZ_BTBD17

cd18292

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

58-147

8.88e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349601 [Multi-domain] Cd Length: 114 Bit Score: 44.97 E-value: 8.88e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624  58 SSVVLQGFDQLRLDGLLCDVTLMPGDTddAYPVHRVMMASASDYFKAMFT------GGMKEQELM----CIKLHGvsrvg 127
Cdd:cd18292    1 SREFLQDIAQLYNNEELSDIVLRVGGK--VFHAHRLILAKSSDVFRVMLSndwwseSKQSEIELVedpeCAAVFE----- 73

                         90       100
                 ....*....|....*....|
gi 755564624 128 lrKIIDFIYTAKLSLNMDTL 147
Cdd:cd18292   74 --KFLRYLYTGQISVNLETA 91

BTB_POZ_ZBTB25_ZNF46_KUP

cd18213

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

54-121

9.87e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25); ZBTB25, also called zinc finger protein 46 (ZNF46) or zinc finger protein KUP, is a transcription repressor that facilitates viral RNA transcription and replication. It interacts with viral RNA-dependent RNA polymerase (RdRp) proteins and modulates their transcription activity. It also functions as a viral RNA-binding protein, binding preferentially to the U-rich sequence within 5' UTR of vRNA. ZBTB25 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349522 [Multi-domain] Cd Length: 128 Bit Score: 45.27 E-value: 9.87e-06

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755564624  54 SNSHSSVVLQGFDQLRLDGLLCDVTLMPGDTddAYPVHRVMMASASDYFKAMFTggmkEQELMCIKLH 121
Cdd:cd18213    1 VSSHSLVLLQQLNMQREFGFLCDCTVAIGDV--YFKAHRAVLAAFSNYFKMIFI----HQSSECIKIQ 62

BACK_KLHL35

cd18474

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs ...

178-252

1.06e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs to the KLHL family. Its function remains unclear. Hypermethylation of KLHL35 is associated with hepatocellular carcinoma and abdominal aortic aneurysm.

Pssm-ID: 350549 [Multi-domain] Cd Length: 79 Bit Score: 44.03 E-value: 1.06e-05

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755564624 178 NCVEVGRIANTYHLTEVDKYVNSFVLKNFAALLSTGEFLKLPFERLAFVLSSNSLKRCTELDLFKATCRWLRLEE 252
Cdd:cd18474    5 NCLALLAAADALHCAPLQEHCIRVLLRDFAQAARHPSFLKLELQLVLELLADDSLAVRSEEVVLEAALRWVDADP 79

BACK_KLHL8

cd18448

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a ...

178-268

1.10e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.

Pssm-ID: 350523 [Multi-domain] Cd Length: 97 Bit Score: 44.22 E-value: 1.10e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624 178 NCVEVGRIANTYHLTEVDKYVNSFVLKNFAALLSTGEFLKLPFERLAFVLSSNSLKRCTELDLFKATCRWLRLE-EPRMD 256
Cdd:cd18448    6 NCLGVRTFAEQHNRVDLMKMADKYACDHFNEVVECEEFVSISAQHLEKLISSSDLNVESESQVYEAVMKWVKHDpQHRKR 85

                         90
                 ....*....|..
gi 755564624 257 VAAKLMKNIRFP 268
Cdd:cd18448   86 HLDDLLSQVRLP 97

BTB_POZ_BTBD1_2

cd18281

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

73-178

1.13e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349590 [Multi-domain] Cd Length: 127 Bit Score: 45.12 E-value: 1.13e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624  73 LLCDVTLMPG--DTDDAYPVHRVMMASASDYFKAMFTGGMKEQELMcIKLHGVSRVGLRKIIDFIYTAKLSLNMDTLQDT 150
Cdd:cd18281   21 TLSDVHFIVGkgDNEQRIPAHKFVLSIGSAVFDAMFNGGMATTSAE-IELPDVEPAAFLALLRFLYSDEVQIGPETVMTT 99

                         90       100
                 ....*....|....*....|....*....
gi 755564624 151 LEAASFLQIlPVLD-FCKVFLISGVTLDN 178
Cdd:cd18281  100 LYTAKKYAV-PALEsACVEFLKKNLSSDN 127

BACK_KLHL10

cd18450

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be ...

175-247

1.17e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis.

Pssm-ID: 350525 [Multi-domain] Cd Length: 80 Bit Score: 43.75 E-value: 1.17e-05

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755564624 175 TLDNCVEVGRIANTYHLTEVDKYVNSFVLKNFAALLSTG-EFLKLPFERLAFVLSSNSLKRCTELDLFKATCRW 247
Cdd:cd18450    2 TPENCIGIRKFARYYFCPELERKAYRYILRNFEEVAKDSeEFLELSCEELEDIIEDDELNVKEEEVVFEAIVKW 75

BTB_POZ_ZBTB16_PLZF

cd18205

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

57-159

1.24e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 16 (ZBTB16); ZBTB16 is also called promyelocytic leukemia zinc finger protein, zinc finger protein 145, or zinc finger protein PLZF. It is a DNA-binding transcription factor essential for undifferentiated cell maintenance. ZBTB16 also acts as a downstream transcriptional regulator of Osterix and can be useful as a late marker of osteoblastic differentiation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349514 [Multi-domain] Cd Length: 107 Bit Score: 44.64 E-value: 1.24e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624  57 HSSVVLQGFDQLRLDGLLCDVTLMPGDTDdaYPVHRVMMASASDYFKAMFTGGMKEqelmcIKLHGVSRVGLRKIIDFIY 136
Cdd:cd18205    1 HPTGLLHKANQMRLAGTLCDVVIMVDSQE--FHAHRTVLACTSKMFEILFHRNSQH-----YTLDFLSPKTFQQILEYAY 73

                         90       100
                 ....*....|....*....|...
gi 755564624 137 TAKLSLNMDTLQDTLEAASFLQI 159
Cdd:cd18205   74 TATLQAKVEDLDDLLYAAEILEI 96

BTB2_POZ_IBtk

cd18302

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

74-178

1.36e-05

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349611 [Multi-domain] Cd Length: 113 Bit Score: 44.66 E-value: 1.36e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624  74 LCDVTLMPGDTDDaYPVHRVMMASASDYFKAMFTGGMKE-QELMCIKLHGVSRVgLRKIIDFIYT-----AKLSLNMDTL 147
Cdd:cd18302    5 LYDVTIVSEDGKE-FPCHKCVLVARLEYFHSMLSSSWIEaSSCSALTMPIPSDI-LEIILDYLYTdeasaVKESQNVEFL 82

                         90       100       110
                 ....*....|....*....|....*....|.
gi 755564624 148 QDTLEAASFLQILPVLDFCKVFLISGVTLDN 178
Cdd:cd18302   83 CNVLVIADQLLITRLKEICEVALVELLSLKN 113

BTB_POZ_KLHL29_KBTBD9

cd18258

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

88-180

1.57e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349567 [Multi-domain] Cd Length: 125 Bit Score: 44.58 E-value: 1.57e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624  88 YPVHRVMMASASDYFKAMFTGGMKEQ---ELMCIKLHGVSRVGLRKIIDFIYTAKLSLNMDTLQDTLEAASFLQIlpvLD 164
Cdd:cd18258   29 FEVHQNVLASCSLYFKDLIKRSSRDSgggEKLELTMSNINADVLELLLEFVYTGSLIIDSANAKTLLEAANKFQF---HT 105

                         90
                 ....*....|....*....
gi 755564624 165 FCKV---FLISGVTLDNCV 180
Cdd:cd18258  106 FCKVcvsFLEKQLTASNCL 124

PLN02193

nitrile-specifier protein

345-454

1.62e-05

nitrile-specifier protein

Pssm-ID: 177844 [Multi-domain] Cd Length: 470 Bit Score: 47.64 E-value: 1.62e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624 345 YDEKTHEWKSLAPMD---APRYQHGIAVIGNFLYVVGGQSnydtkGKTAVDTVFRFDPRYNKWIQVASLNEK---RTFFH 418
Cdd:PLN02193 249 FDTTTNEWKLLTPVEegpTPRSFHSMAADEENVYVFGGVS-----ATARLKTLDSYNIVDKKWFHCSTPGDSfsiRGGAG 323

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 755564624 419 LSALKGFLYAVGGRNAAgELPTVECYNPRTNEWTYV 454
Cdd:PLN02193 324 LEVVQGKVWVVYGFNGC-EVDDVHYYDPVQDKWTQV 358

Kelch_3

Galactose oxidase, central domain;

470-514

1.69e-05

Galactose oxidase, central domain;

Pssm-ID: 433188 [Multi-domain] Cd Length: 49 Bit Score: 42.28 E-value: 1.69e-05

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 755564624  470 GGVMYISGGITHD--TFQKELMCFDPDTDKWTQKAPMTTVRGLHCMC 514
Cdd:pfam13415   1 GDKLYIFGGLGFDgqTRLNDLYVYDLDTNTWTQIGDLPPPRSGHSAT 47

Kelch_6

pfam13964

Kelch motif;

414-460

1.95e-05

Kelch motif;

Pssm-ID: 404790 [Multi-domain] Cd Length: 50 Bit Score: 42.32 E-value: 1.95e-05

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 755564624  414 RTFFHLSALKGFLYAVGGRNAAGE-LPTVECYNPRTNEWTYVAKMNEP 460
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGYTNASPaLNKLEVYNPLTKSWEELPPLPTP 49

BACK_KLHL19_KEAP1

cd18458

BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); ...

176-252

2.07e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also termed cytosolic inhibitor of Nrf2 (INrf2), or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression.

Pssm-ID: 350533 [Multi-domain] Cd Length: 91 Bit Score: 43.44 E-value: 2.07e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624 176 LD--NCVEVGRIANTYHLTEVDKYVNSFVLKNFAALLSTGEFLKLPFERLAFVLSSNSLK-RCtELDLFKATCRWLRLEE 252
Cdd:cd18458    2 LDpsNCIGIANFAEQHGCTELHKKAREYIYMHFSEVSQSEEFFNLSPCQLVALISRDELNvRC-ESEVYNAVIRWVKYDE 80

BTB_POZ_BTBD2

cd18347

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

59-178

2.16e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 2 (BTBD2); BTBD2 is a BTB-domain-containing Kelch-like protein that interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349656 [Multi-domain] Cd Length: 127 Bit Score: 44.29 E-value: 2.16e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624  59 SVVLQGFDQLRLDGLLCDVTLMPGD--TDDAYPVHRVMMASASDYFKAMFTGGMKEQELMcIKLHGVSRVGLRKIIDFIY 136
Cdd:cd18347    7 PTVQERFAFLFNNEVLSDVHFLVGKglGSQRIPAHRFVLAVGSAVFDAMFNGGMATTSTE-IELPDVEPAAFLALLKFLY 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 755564624 137 TAKLSLNMDTLQDTLEAASFLQILPVLDFCKVFLISGVTLDN 178
Cdd:cd18347   86 SDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADN 127

BTB_POZ_ZBTB33_KAISO

cd18219

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

57-157

2.76e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kaiso; Kaiso, also called zinc finger and BTB domain-containing protein 33 (ZBTB33), is a DNA methylation-dependent transcriptional repressor that binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3'. It also binds to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349528 [Multi-domain] Cd Length: 106 Bit Score: 43.67 E-value: 2.76e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624  57 HSSVVLQGFDQLRLDGLLCDVTLMPgdTDDAYPVHRVMMASASDYFKAMFTGGMKEQELMCIKLHGVSrvglrKIIDFIY 136
Cdd:cd18219    4 YSGSLLKSLNEQRGHGLFCDVTVIV--EDRKFRAHKNILSASSTYFHQLFSVAGQVVELNFIRADIFA-----EILNYIY 76

                         90       100
                 ....*....|....*....|..
gi 755564624 137 TAKL-SLNMDTLQDTLEAASFL 157
Cdd:cd18219   77 SSKIvRVRSDLLEELIKSGQLL 98

BTB_POZ_ZBTB14

cd18204

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

57-159

3.36e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349513 [Multi-domain] Cd Length: 114 Bit Score: 43.49 E-value: 3.36e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624  57 HSSVVLQGFDQLRLDGLLCDVTLMPGDTddAYPVHRVMMASASDYFKAMFtggmKEQEL---MCIKLHGVSRVGLRKIID 133
Cdd:cd18204    1 HKTVFLKTLNEQRLEGEFCDIAIVVEDV--KFRAHRCVLAACSTYFKKLF----KKLEVdssSVIEIDFLRSDIFEEVLN 74

                         90       100
                 ....*....|....*....|....*.
gi 755564624 134 FIYTAKLSLNMDTLQDTLEAASFLQI 159
Cdd:cd18204   75 YMYTAKISVKKEDVNLMMSSGQILGI 100

BTB_POZ_BTBD1

cd18346

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

81-178

3.56e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 1 (BTBD1); BTBD1, also called Hepatitis C virus NS5A-transactivated protein 8 or HCV NS5A-transactivated protein 8, is a BTB-domain-containing Kelch-like protein that is expressed in skeletal muscle and interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. BTBD1 may serve as substrate-specific adaptor of an E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349655 [Multi-domain] Cd Length: 133 Bit Score: 43.89 E-value: 3.56e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624  81 PGDTDDAYPVHRVMMASASDYFKAMFTGGMKEQELMcIKLHGVSRVGLRKIIDFIYTAKLSLNMDTLQDTLEAASFLQIL 160
Cdd:cd18346   37 PGPGAQRIPAHRFVLAAGSAVFDAMFNGGMATTSAE-IELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVP 115

                         90
                 ....*....|....*...
gi 755564624 161 PVLDFCKVFLISGVTLDN 178
Cdd:cd18346  116 ALEAHCVEFLTKHLRADN 133

BACK_KLHL21

cd18460

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a ...

176-270

3.72e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively.

Pssm-ID: 350535 [Multi-domain] Cd Length: 101 Bit Score: 42.86 E-value: 3.72e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624 176 LDNCVEVGRIANTYHLTEVDKYVNSFVLKNFAALLSTGEFLKLPFERLAFVLSSNSLKRCTELDLFKATCRWLRLEEP-R 254
Cdd:cd18460    3 VSNCLEMQDFAEAFACRGLAEAAKRFILRHIVELAKGEQFERLPLKRLLEYLSDDGLCVDKEETAYQIALRWVKADPKhR 82

                         90
                 ....*....|....*.
gi 755564624 255 MDVAAKLMKNIRFPLM 270
Cdd:cd18460   83 QHFWPELLQHVRLPFV 98

BTB_POZ_GCL

cd18305

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

65-166

5.26e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349614 [Multi-domain] Cd Length: 115 Bit Score: 43.04 E-value: 5.26e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624  65 FDQLRLDGLLCDVTLMPGDTDdaYPVHRVMMaSASDYFKAMFTGGMKEQELMCIKL----HGVSRVGLRKIIDFIYTAKL 140
Cdd:cd18305    6 YQTLFLNGENSDITICALGRE--WKLHKIYL-CQSGYFASMFSGSWKESKETVINLeipdDNITVEALNVVFGSLYRDEI 82

                         90       100
                 ....*....|....*....|....*.
gi 755564624 141 SLNMDTLQDTLEAASFLQILPVLDFC 166
Cdd:cd18305   83 EIKPSRVVSILAAATLLQLDGLIQQC 108

BTB1_POZ_ABTB1_BPOZ1

cd18295

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

88-149

6.83e-05

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349604 [Multi-domain] Cd Length: 119 Bit Score: 42.62 E-value: 6.83e-05

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755564624  88 YPVHRVMMASASDYFKAMFTGGMKEQELMCIKLHGVSRVGLRKIIDFIYTAKLSLNMDTLQD 149
Cdd:cd18295   31 FPAHRCILSARSPYFAEMFETKWKDKREINLKHPLVNPDAFRALLQYLYTGRLEIHVDDVED 92

BTB_POZ_TDPOZ

cd18344

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

91-139

7.44e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349653 [Multi-domain] Cd Length: 128 Bit Score: 43.02 E-value: 7.44e-05

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 755564624  91 HRVMMASASDYFKAMFTGGMKEQELMCIKLHGVSRVGLRKIIDFIYTAK 139
Cdd:cd18344   38 HKAILAARSPVFRAMFEHEMEERLKNPIEIHDLDPQVFKEMMGFIYTGK 86

BTB_POZ_ZBTB12

cd18203

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

57-167

7.83e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 12 (ZBTB12); ZBTB12, also called protein G10, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349512 [Multi-domain] Cd Length: 122 Bit Score: 42.56 E-value: 7.83e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624  57 HSSVVLQGFDQLRLDGLLCDVTLMPGDTddAYPVHRVMMASASDYFKAMFTggMKEQELMCIKLHGVSRVgLRKIIDFIY 136
Cdd:cd18203    8 HEAATLRNMNQLRSEERFCDVTIVADSL--KFRGHKVVLAACSPFLRDQFL--LNPSSELQVSLMHSSRV-VADLLLSCY 82

                         90       100       110
                 ....*....|....*....|....*....|.
gi 755564624 137 TAKLSLNMDTLQDTLEAASFLQILPVLDFCK 167
Cdd:cd18203   83 TGALEFSVRDIVNYLTAASYLQMEHVVEKCR 113

BTB_POZ_ZBTB40

cd18225

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

56-172

8.23e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 40 (ZBTB40); ZBTB40 may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB40 are associated with bone mineral density in European and East-Asian populations. ZBTB40 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349534 [Multi-domain] Cd Length: 116 Bit Score: 42.51 E-value: 8.23e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624  56 SHSSVVLQGFDQLRLDGLLCDVTLMPGDTDdaYPVHRVMMASASDYFKAMFTGgmkeQELMCIKLHGVSRVGLRKIIDFI 135
Cdd:cd18225    5 NYSRQLLQQLHTLRKEQQFCDCTIFIGTFH--FRAHKLVLAASSLLFKSLLDS----TDTISIDASVVSPEEFALLLEMV 78

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 755564624 136 YTAKLSLNMDTLQDTLEAASFLQILPVLDFCKVFLIS 172
Cdd:cd18225   79 YTGKLPPGKHNFTKIISVADSLQMFDVAVSCKNLLTS 115

BTB_POZ_BTBD3_6

cd18282

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

73-154

8.66e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349591 [Multi-domain] Cd Length: 108 Bit Score: 42.00 E-value: 8.66e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624  73 LLCDVTLMPGDTDDA--YPVHRVMMASASDYFKAMFTGGMKEQELMcIKLHGVSRVGLRKIIDFIYTAKLSLNMDTLQDT 150
Cdd:cd18282    6 LMADVHFIVGPPGGTqrIPAHKYVLATGSSVFYAMFYGGLAENKNE-IEIPDVEPAAFLNLLRYLYCDEIDLEPDTVLAT 84


                 ....
gi 755564624 151 LEAA 154
Cdd:cd18282   85 LYAA 88

BTB_POZ_SPOPL

cd18343

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

88-178

1.42e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349652 [Multi-domain] Cd Length: 123 Bit Score: 41.91 E-value: 1.42e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624  88 YPVHRVMMASASDYFKAMFTGGMKEQELMCIKLHGVSRVGLRKIIDFIYTAKlSLNMDTLQDTLEAAS---FLQILPVLd 164
Cdd:cd18343   33 FKAHKSILAARSPVFNAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTGK-APNLDKMADNLLAAAdkyALERLKVM- 110

                         90
                 ....*....|....
gi 755564624 165 fCKVFLISGVTLDN 178
Cdd:cd18343  111 -CEEALCNNLSVEN 123

BACK_KLHL23

cd18462

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is ...

176-269

1.71e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is involved in tumorigenesis and resistance to anticancer drug treatment. It also associates with cone-rod dystrophy.

Pssm-ID: 350537 [Multi-domain] Cd Length: 102 Bit Score: 41.26 E-value: 1.71e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624 176 LDNCVEVGRIANTYHLTEVDKYVNSFVLKNFAALLSTGEFLKLPFERLAFVLSSNSLKRCTELDLFKATCRWLRLE-EPR 254
Cdd:cd18462    3 IDNCLGMHSFAEFHVCPELEKESRRIILSRFEEVWQQEEFLELSKEKLLYILSRENLNVWKEEVLIEAVVKWVAHDvEKR 82

                         90
                 ....*....|....*
gi 755564624 255 MDVAAKLMKNIRFPL 269
Cdd:cd18462   83 IECAYDLLSSIKLDL 97

mutarot_permut

TIGR03548

cyclically-permuted mutarotase family protein; Members of this protein family show essentially ...

465-606

1.75e-04

Pssm-ID: 274642 [Multi-domain] Cd Length: 331 Bit Score: 44.01 E-value: 1.75e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624  465 AGTVYGGVMYISGGITHDTFQKELMCFDPDTD--KWTQKAPMTTVRGLHCMCTV-GDRLYVIGGNHFRGT-SDYDDVLSc 540
Cdd:TIGR03548 119 SATYKDGKIYVGGGNANGKPSNKFYCLDLSNDtsGWEELPEFPGEARVQPVCQAlHGKLYVFGGFQLGGDaIIYTDGYA- 197

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624  541 eyYSPILDQWTPIASMLRGQSD-------VGVAVFENKIYVVGG-----------------------------------Y 578
Cdd:TIGR03548 198 --YSPKTNTWQTVADPVLSDGEpitllggNSVKLGDSLMLVIGGvnydiffdavdrlrqmkdeslksekaeyfghppqwY 275

                         170       180
                  ....*....|....*....|....*...
gi 755564624  579 SWNNRCMVeivqkYDPEKNEWHKVFDLP 606
Cdd:TIGR03548 276 RFNDKVLI-----YNVRSNEWKSIGAVP 298

BTB_POZ_BTBD11

cd18351

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

91-181

1.86e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 11 (BTBD11); BTBD11, also called ankyrin repeat and BTB/POZ domain-containing protein BTBD11, is a BTB-domain-containing protein. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349660 [Multi-domain] Cd Length: 131 Bit Score: 41.89 E-value: 1.86e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624  91 HRVMMASASDYFKAMFTGgMKEQELMCIKLHGVSRVGLRKIIDFIY---TAKLSLNMDTLQDTLEAASFLQILPVLDFCK 167
Cdd:cd18351   39 HKVLLFTASPRFKALLSN-KPSAENTCIEISYVKYHIFQLVMQYLYcggTESLLIKNNEIMELLSAAKFFQLEALQRHCE 117

                         90
                 ....*....|....
gi 755564624 168 VFLISGVTLDNCVE 181
Cdd:cd18351  118 IICAKSINTENCVD 131

BACK_KLHL11

cd18451

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a ...

174-249

2.30e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.

Pssm-ID: 350526 [Multi-domain] Cd Length: 88 Bit Score: 40.33 E-value: 2.30e-04

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755564624 174 VTLDNCVEVGRIANTYHLTEVDKYVNSFVLKNFAALLSTGEFLKLPFERLAFVLSSNSLKRCTELDLFKATCRWLR 249
Cdd:cd18451    1 LNLSNCVAIHSLAHMYSLDQLALKAADMIRRNFHKVIQDEEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVLKWVQ 76

BTB_POZ_ZBTB41

cd18226

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

88-160

2.97e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41); ZBTB41, also called FRBZ1, may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349535 [Multi-domain] Cd Length: 114 Bit Score: 40.94 E-value: 2.97e-04

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755564624  88 YPVHRVMMASASDYFKAMFTggmKEQELMCIKLHGVSRVGLRKIIDFIYTAKLSLNMDTLQDTLEAASFLQIL 160
Cdd:cd18226   34 FSAHKVVVAVGSSYFHACLS---KNPNTDAVTLDHVSYSVFQHLLEFLYTSEFFVYENEIPLVLEAAKFLDII 103

BACK_KLHL27_IPP

cd18466

BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide ...

178-275

3.18e-04

BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also termed Kelch-like protein 27 (KLHL27), is an actin-binding protein that may play a role in organizing the actin cytoskeleton.

Pssm-ID: 350541 [Multi-domain] Cd Length: 103 Bit Score: 40.54 E-value: 3.18e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624 178 NCVEVGRIANTYHLTEVDKYVNSFVLKNFAALLSTGEFLKLPFERLAFVLSSNSLKRCTELDLFKATCRWLRLEEP-RMD 256
Cdd:cd18466    5 NCIGIFQFSEQIACHDLLEFTENYIHVHFLEVQSGEEFLGLTKDQLVKILRSEELSIEDEYQVFTAAMEWILKDVGkRKK 84

                         90
                 ....*....|....*....
gi 755564624 257 VAAKLMKNIRFPLMTPQEL 275
Cdd:cd18466   85 HVVEVLEPVRFPLLPPQRL 103

BTB_POZ_SPOP

cd18342

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

88-178

4.19e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349651 [Multi-domain] Cd Length: 125 Bit Score: 40.47 E-value: 4.19e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624  88 YPVHRVMMASASDYFKAMFTGGMKEQELMCIKLHGVSRVGLRKIIDFIYTAKLSlNMDTLQDTLEAAS---FLQILPVLd 164
Cdd:cd18342   34 FQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYTGKAP-NLDKMADDLLAAAdkyALERLKVM- 111

                         90
                 ....*....|....
gi 755564624 165 fCKVFLISGVTLDN 178
Cdd:cd18342  112 -CEDALCSNLSVEN 124

PRK14131

N-acetylneuraminate epimerase;

549-602

4.85e-04

N-acetylneuraminate epimerase;

Pssm-ID: 237617 [Multi-domain] Cd Length: 376 Bit Score: 42.69 E-value: 4.85e-04

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 755564624 549 QWTPIASMLRGQSDVGVAVF-ENKIYVVGGYSWNNRCMVEIVQ----KYDPEKNEWHKV 602
Cdd:PRK14131  63 GWTKIAAFPGGPREQAVAAFiDGKLYVFGGIGKTNSEGSPQVFddvyKYDPKTNSWQKL 121

Kelch_3

Galactose oxidase, central domain;

371-422

5.51e-04

Galactose oxidase, central domain;

Pssm-ID: 433188 [Multi-domain] Cd Length: 49 Bit Score: 38.04 E-value: 5.51e-04

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 755564624  371 GNFLYVVGGqsnYDTKGKTAVDTVFRFDPRYNKWIQVASLNEKRTFFHLSAL 422
Cdd:pfam13415   1 GDKLYIFGG---LGFDGQTRLNDLYVYDLDTNTWTQIGDLPPPRSGHSATYI 49

BACK_KBTBD8

cd18483

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...

178-268

6.01e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor for a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralogue TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome.

Pssm-ID: 350558 [Multi-domain] Cd Length: 97 Bit Score: 39.46 E-value: 6.01e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624 178 NCVEVGRIANTYHLTEVDKYVNSFVLKNFAALLSTGEFLKLPFERLAFVLSSNSLKRCTELDLFKATCRWLRLEEPR--M 255
Cdd:cd18483    5 NSIGVFIFADHYGHQELKERSQDYIRKKFLSVTKEQEFLHLTKDQLISILNSDDLNVEKEEHVYESIIHWFEHEQSKreM 84

                         90
                 ....*....|...
gi 755564624 256 DVAAKLMKNIRFP 268
Cdd:cd18483   85 HLPEIFAKCIRMP 97

Kelch_6

pfam13964

Kelch motif;

460-506

6.10e-04

Kelch motif;

Pssm-ID: 404790 [Multi-domain] Cd Length: 50 Bit Score: 38.09 E-value: 6.10e-04

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 755564624  460 PHYGHAGTVYGGVMYISGGITHD-TFQKELMCFDPDTDKWTQKAPMTT 506
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYTNAsPALNKLEVYNPLTKSWEELPPLPT 48

PHA02790

Kelch-like protein; Provisional

467-600

6.12e-04

Kelch-like protein; Provisional

Pssm-ID: 165153 [Multi-domain] Cd Length: 480 Bit Score: 42.72 E-value: 6.12e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624 467 TVYGGVMYISGGITHDTFQKELMCFDPDTDKWTQKAPMTTVRGLHCMCTVGDRLYVIGGnhfrgtsdYDDVLSCEYYSPI 546
Cdd:PHA02790 268 THVGEVVYLIGGWMNNEIHNNAIAVNYISNNWIPIPPMNSPRLYASGVPANNKLYVVGG--------LPNPTSVERWFHG 339

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 755564624 547 LDQWTPIASMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVqkydPEKNEWH 600
Cdd:PHA02790 340 DAAWVNMPSLLKPRCNPAVASINNVIYVIGGHSETDTTTEYLL----PNHDQWQ 389

BTB_POZ_ZBTB2

cd18193

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

56-163

6.16e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 2 (ZBTB2); ZBTB2 is a POZ domain Kruppel-like zinc finger (POK) family transcription factor acting as a potent repressor of the ARF-HDM2-p53-p21 pathway, which is important in cell cycle regulation. It represses transcription of the ARF, p53, and p21 genes, but activates the HDM2 gene. ZBTB2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349502 [Multi-domain] Cd Length: 115 Bit Score: 39.98 E-value: 6.16e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624  56 SHSSVVLQGFDQLRLDGLLCDVTLMPGDTddAYPVHRVMMASASDYFKAMFTggmkEQELMCIKLH--GVSRVGLRKIID 133
Cdd:cd18193    3 NHGLILLQQLNAQREFGFLCDCTVAIGDV--YFKAHKSVLASFSNYFKMLFV----HQTSECVRLKptDIQPDIFSYLLH 76

                         90       100       110
                 ....*....|....*....|....*....|
gi 755564624 134 FIYTAKLSLNMDTLQDTLEAASFLQILPVL 163
Cdd:cd18193   77 LMYTGKMAPQLIDPVRLEQGIKFLHAYPLI 106

Kelch

Kelch domain;

324-372

6.47e-04

Kelch domain;

Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 37.92 E-value: 6.47e-04

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 755564624   324 RLVTLGGVLRQQlvVSKELRMYDEKTHEWKSLAPMDAPRYQHGIAVIGN 372
Cdd:smart00612   1 KIYVVGGFDGGQ--RLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47

Kelch_2

pfam07646

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

460-504

7.69e-04

Pssm-ID: 462220 [Multi-domain] Cd Length: 47 Bit Score: 37.70 E-value: 7.69e-04

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 755564624  460 PHYGHAGTVYGGVMYISGGITH--DTFQKELMCFDPDTDKWTQKAPM 504
Cdd:pfam07646   1 PRYPHASSVPGGKLYVVGGSDGlgDLSSSDVLVYDPETNVWTEVPRL 47

Kelch_2

pfam07646

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

559-602

8.32e-04

Pssm-ID: 462220 [Multi-domain] Cd Length: 47 Bit Score: 37.70 E-value: 8.32e-04

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 755564624  559 GQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPEKNEWHKV 602
Cdd:pfam07646   1 PRYPHASSVPGGKLYVVGGSDGLGDLSSSDVLVYDPETNVWTEV 44

BACK_KLHL40_KBTBD5

cd18516

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also ...

176-270

1.06e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5, or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy.

Pssm-ID: 350591 [Multi-domain] Cd Length: 99 Bit Score: 38.97 E-value: 1.06e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624 176 LDNCVEVGRIANTYHLTEVDKYVNSFVLKNFAALLSTGEFLKLPFERLAFVLSSNSLKRCTELDLFKATCRWLRLE-EPR 254
Cdd:cd18516    3 LSNCLAIFRLGLLLDCPRLAVAARDFICDRFQLIARDEDFLQLSPDELIAIISSDSLNVEKEEDVFEAVMKWVGKDqEER 82

                         90
                 ....*....|....*.
gi 755564624 255 MDVAAKLMKNIRFPLM 270
Cdd:cd18516   83 TKALPVLLESIRFRLM 98

BACK_NS1BP_IVNS1ABP

cd18502

BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); ...

174-249

1.25e-03

BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); NS1-BP, also called NS1-binding protein, or Aryl hydrocarbon receptor-associated protein 3, or IVNS1ABP, is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control.

Pssm-ID: 350577 Cd Length: 99 Bit Score: 38.37 E-value: 1.25e-03

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755564624 174 VTLDNCVEVGRIANTYHLTEVDKYVNSFVLKNFAALLSTGEFLKLPFERLAFVLSSN-SLKRCTELDLFKATCRWLR 249
Cdd:cd18502    1 LTPENCIGIRSFAGRMNDSELLQKVDSYIQENIEEVAESKEFLKLPRLQIEVILESNqELESINERKLCQLVLEWVQ 77

BTB2_POZ_RHOBTB1

cd18358

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

85-152

1.41e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1); RhoBTB1 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB1 functions as a tumor suppressor that regulates the integrity of the Golgi complex through the methyltransferase METTL7B. It also acts an adaptor of the Cullin-3-dependent E3 ubiquitin ligase complex. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349667 [Multi-domain] Cd Length: 126 Bit Score: 39.18 E-value: 1.41e-03

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755564624  85 DDAYPVHRVMMASASDYFKAMFTGGMKEQELMCIKLHGVSRVGLRKIIDFIYTAKLSLNMDTlqDTLE 152
Cdd:cd18358   29 DGTINAHKPLLICSCEWMAAMFGGSFIESANSEVVLPNISKVSMQAVLDYLYTKQLSPTADL--DPLE 94

Kelch_5

pfam13854

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

511-538

1.62e-03

Pssm-ID: 433528 [Multi-domain] Cd Length: 41 Bit Score: 36.39 E-value: 1.62e-03

                          10        20
                  ....*....|....*....|....*...
gi 755564624  511 HCMCTVGDRLYVIGGNHFRGTSDYDDVL 538
Cdd:pfam13854   7 HCAVTVGDYIYLYGGYTGGEGQPSDDVY 34

BTB_POZ_BTBD6

cd18349

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

73-170

1.86e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also termed lens BTB domain protein, is a BTB-domain-containing Kelch-like protein required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349658 [Multi-domain] Cd Length: 109 Bit Score: 38.43 E-value: 1.86e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624  73 LLCDVTLM--PGDTDDAYPVHRVMMASASDYFKAMFTGGMKEQELMcIKLHGVSRVGLRKIIDFIYTAKLSLNMDTLQDT 150
Cdd:cd18349    7 LMADVHFIvgPPGASQRVPAHKYVLAVGSSVFYAMFYGDLAEVKSE-IHIPDVEPAAFLILLKYMYSDEIDLEADTVLAT 85

                         90       100
                 ....*....|....*....|.
gi 755564624 151 LEAASfLQILPVL-DFCKVFL 170
Cdd:cd18349   86 LYAAK-KYIVPALaKACVNFL 105

BTB2_POZ_LZTR1

cd18309

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

75-112

3.02e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349618 [Multi-domain] Cd Length: 126 Bit Score: 38.14 E-value: 3.02e-03

                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 755564624  75 CDVTLMPGDTddAYPVHRVMMASASDYFKAMFTGGMKE 112
Cdd:cd18309   21 CDITLLLDGH--PIPAHKAILAARCSYFEAMFRSFMPE 56

Kelch_4

pfam13418

Galactose oxidase, central domain;

565-607

3.07e-03

Galactose oxidase, central domain;

Pssm-ID: 433191 [Multi-domain] Cd Length: 49 Bit Score: 36.05 E-value: 3.07e-03

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 755564624  565 VAVFENKIYVVGGYSWNNRCMVEIVqKYDPEKNEWHKVFDLPE 607
Cdd:pfam13418   8 TSIPDDTIYLFGGEGEDGTLLSDLW-VFDLSTNEWTRLGSLPS 49

Kelch_3

Galactose oxidase, central domain;

423-469

3.84e-03

Galactose oxidase, central domain;

Pssm-ID: 433188 [Multi-domain] Cd Length: 49 Bit Score: 35.73 E-value: 3.84e-03

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 755564624  423 KGFLYAVGGRNAAGE--LPTVECYNPRTNEWTYVAKMNEPHYGHAGTVY 469
Cdd:pfam13415   1 GDKLYIFGGLGFDGQtrLNDLYVYDLDTNTWTQIGDLPPPRSGHSATYI 49

BTB2_POZ_RHOBTB2

cd18359

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

72-145

3.84e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 2 (RhoBTB2); RhoBTB2, also called Deleted in breast cancer 2 gene protein (DBC2) or p83, is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB2 functions as a tumor suppressor that regulates the expression of the methyltransferase METTL7A. It also acts an adaptor of the Cullin-3-dependent E3 ubiquitin ligase complex. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349668 [Multi-domain] Cd Length: 124 Bit Score: 37.68 E-value: 3.84e-03

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755564624  72 GLLCDVTLMPgdTDDAYPVHRVMMASASDYFKAMFTGGMKEQELMCIKLHGVSRVGLRKIIDFIYTAKLSLNMD 145
Cdd:cd18359   18 GTFSDVTFML--DDGTISAHKPLLISSCDWMAAMFGGPFVESSTTEVVFPYTSRSSMRAVLEYLYTGQFSSSPD 89

BACK_KBTBD2

cd18479

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...

174-266

4.05e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulating the insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation.

Pssm-ID: 350554 [Multi-domain] Cd Length: 96 Bit Score: 36.96 E-value: 4.05e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755564624 174 VTLDNCVEVGRIANTYHLTEVDKYVNSFVLKNFAALLSTGEFLKLPFERLAFVLSSNSLKRCTELDLFKATCRWLRLE-E 252
Cdd:cd18479    1 INAENCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQEAFMQLSHDLLIDILSSDNLNVEKEETVREAAMLWLEYNtE 80

                         90
                 ....*....|....
gi 755564624 253 PRMDVAAKLMKNIR 266
Cdd:cd18479   81 SRSQYLSSVLSQIR 94

BACK_KLHL25_ENC2

cd18514

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also ...

203-270

5.10e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1).

Pssm-ID: 350589 [Multi-domain] Cd Length: 99 Bit Score: 36.75 E-value: 5.10e-03

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755564624 203 LKNFAALLSTGEFLKLPFERLAFVLSSNSLKRCTELDLFKATCRWLRLE-EPRMDVAAKLMKNIRFPLM 270
Cdd:cd18514   30 LVHFETVRESEDFYSLSKDKLLDLISSDELEIEDEQVVFNAVLQWVKYDlEKRKDYLPELLRNVRLALL 98

Kelch_3