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Conserved domains on  [gi|755494302|ref|XP_011246307|]
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contactin-associated protein like 5-2 isoform X3 [Mus musculus]

Protein Classification

LamG and EGF domain-containing protein( domain architecture ID 10818108)

LamG and EGF domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 177-296 2.14e-24

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 98.65  E-value: 2.14e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755494302  177 FKTTALSGVFLENLGVKN-FLRLEMSSpSEVIFAIDVGNGPMELLVqSPYPLNDNQWHYIQAERNIKETLLHVDNLPKSM 255
Cdd:pfam02210   1 FRTRQPNGLLLYAGGGGSdFLALELVN-GRLVLRYDLGSGPESLLS-SGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVS 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 755494302  256 RMASEEGHFlLQLNSQLFVGG--------TSSRQKGFLGCIRSLHLNGQ 296
Cdd:pfam02210  79 SLPPGESLL-LNLNGPLYLGGlppllllpALPVRAGFVGCIRDVRVNGE 126
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 402-530 4.58e-20

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 86.32  E-value: 4.58e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755494302  402 FMTAQAPTLLLYLNFSSQNFLAILLsRNGSLQIQYRLSKEESHVFTiSTENLANRRVHQVKMSRDGPELSIQMDQQ-LFS 480
Cdd:pfam02210   1 FRTRQPNGLLLYAGGGGSDFLALEL-VNGRLVLRYDLGSGPESLLS-SGKNLNDGQWHSVRVERNGNTLTLSVDGQtVVS 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 755494302  481 YNFPPEVE-FQTVRSLILGKVtetLGLDPEVAKANTLGFVGCLSSVQYNHI 530
Cdd:pfam02210  79 SLPPGESLlLNLNGPLYLGGL---PPLLLLPALPVRAGFVGCIRDVRVNGE 126
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 318-351 2.31e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.90  E-value: 2.31e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 755494302  318 CNSYgrNCQNGGKCVEKHIGYTCDCTNsPYEGPF 351
Cdd:pfam00008   1 CAPN--PCSNGGTCVDTPGGYTCICPE-GYTGKR 31
DUF1566 super family cl06585
Protein of unknown function (DUF1566); These proteins of unknown function are found in ...
 2-87 5.37e-03

Protein of unknown function (DUF1566); These proteins of unknown function are found in Leptospira interrogans and in several gamma proteobacteria.


The actual alignment was detected with superfamily member pfam07603:

Pssm-ID: 429556 [Multi-domain]  Cd Length: 117  Bit Score: 37.36  E-value: 5.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755494302    2 TVQHNNTELTWIQGSNTEKP--------YVMNLN---YGG-------SMEQLEALIDgsehceqevtyYCRRSHLLNT-- 61
Cdd:pfam07603   2 TVTDNLTGLMWQRCAEAGATcswqdalaYCAALNaagFAGysdwrlpTIRELLSLVD-----------YSRASPAINTta 70

                          90       100
                  ....*....|....*....|....*....
gi 755494302   62 -PDGAPFAWWTGRSNERHPY--WGGYFPG 87
Cdd:pfam07603  71 fPNTPPFYYWSSTTSAGNPDyaWAVNFAD 99
 
Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 177-296 2.14e-24

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 98.65  E-value: 2.14e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755494302  177 FKTTALSGVFLENLGVKN-FLRLEMSSpSEVIFAIDVGNGPMELLVqSPYPLNDNQWHYIQAERNIKETLLHVDNLPKSM 255
Cdd:pfam02210   1 FRTRQPNGLLLYAGGGGSdFLALELVN-GRLVLRYDLGSGPESLLS-SGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVS 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 755494302  256 RMASEEGHFlLQLNSQLFVGG--------TSSRQKGFLGCIRSLHLNGQ 296
Cdd:pfam02210  79 SLPPGESLL-LNLNGPLYLGGlppllllpALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 150-294 2.24e-24

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 99.41  E-value: 2.24e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755494302 150 AVSFSTEAaYLHIPTFHAE-FSADISFFFKTTALSGV--FLENLGVKNFLRLEMSSpSEVIFAIDvgNGPMELLVQSPYP 226
Cdd:cd00110    1 GVSFSGSS-YVRLPTLPAPrTRLSISFSFRTTSPNGLllYAGSQNGGDFLALELED-GRLVLRYD--LGSGSLVLSSKTP 76

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755494302 227 LNDNQWHYIQAERNIKETLLHVDNLPkSMRMASEEGHFLLQLNSQLFVGGT--------SSRQKGFLGCIRSLHLN 294
Cdd:cd00110   77 LNDGQWHSVSVERNGRSVTLSVDGER-VVESGSPGGSALLNLDGPLYLGGLpedlkspgLPVSPGFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
172-296 6.01e-23

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 94.71  E-value: 6.01e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755494302   172 DISFFFKTTALSGV--FLENLGVKNFLRLEMSSpSEVIFAIDVGNGPMELLVQsPYPLNDNQWHYIQAERNIKETLLHVD 249
Cdd:smart00282   1 SISFSFRTTSPNGLllYAGSKGGGDYLALELRD-GRLVLRYDLGSGPARLTSD-PTPLNDGQWHRVAVERNGRSVTLSVD 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 755494302   250 NLPkSMRMASEEGHFLLQLNSQLFVGGT--------SSRQKGFLGCIRSLHLNGQ 296
Cdd:smart00282  79 GGN-RVSGESPGGLTILNLDGPLYLGGLpedlklppLPVTPGFRGCIRNLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 402-530 4.58e-20

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 86.32  E-value: 4.58e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755494302  402 FMTAQAPTLLLYLNFSSQNFLAILLsRNGSLQIQYRLSKEESHVFTiSTENLANRRVHQVKMSRDGPELSIQMDQQ-LFS 480
Cdd:pfam02210   1 FRTRQPNGLLLYAGGGGSDFLALEL-VNGRLVLRYDLGSGPESLLS-SGKNLNDGQWHSVRVERNGNTLTLSVDGQtVVS 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 755494302  481 YNFPPEVE-FQTVRSLILGKVtetLGLDPEVAKANTLGFVGCLSSVQYNHI 530
Cdd:pfam02210  79 SLPPGESLlLNLNGPLYLGGL---PPLLLLPALPVRAGFVGCIRDVRVNGE 126
LamG smart00282
Laminin G domain;
398-529 1.26e-12

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 65.44  E-value: 1.26e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755494302   398 ITLSFMTAQAPTLLLYLNFSSQN-FLAILLsRNGSLQIQYRLSKEESHVfTISTENLANRRVHQVKMSRDGPELSIQMDQ 476
Cdd:smart00282   2 ISFSFRTTSPNGLLLYAGSKGGGdYLALEL-RDGRLVLRYDLGSGPARL-TSDPTPLNDGQWHRVAVERNGRSVTLSVDG 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 755494302   477 QLFSY--NFPPEVEFQTVRSLILGKVTETLGLDPEVakaNTLGFVGCLSSVQYNH 529
Cdd:smart00282  80 GNRVSgeSPGGLTILNLDGPLYLGGLPEDLKLPPLP---VTPGFRGCIRNLKVNG 131
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 389-528 1.51e-10

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 59.74  E-value: 1.51e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755494302 389 KDTAPSKEAITLSFMTAQAPTLLLYL-NFSSQNFLAILLsRNGSLQIQYRLSKEeSHVFTiSTENLANRRVHQVKMSRDG 467
Cdd:cd00110   15 LPAPRTRLSISFSFRTTSPNGLLLYAgSQNGGDFLALEL-EDGRLVLRYDLGSG-SLVLS-SKTPLNDGQWHSVSVERNG 91

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755494302 468 PELSIQMDQQLF--SYNFPPEVEFQTVRSLILGKVTETLGLDPEVakaNTLGFVGCLSSVQYN 528
Cdd:cd00110   92 RSVTLSVDGERVveSGSPGGSALLNLDGPLYLGGLPEDLKSPGLP---VSPGFVGCIRDLKVN 151
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 318-351 2.31e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.90  E-value: 2.31e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 755494302  318 CNSYgrNCQNGGKCVEKHIGYTCDCTNsPYEGPF 351
Cdd:pfam00008   1 CAPN--PCSNGGTCVDTPGGYTCICPE-GYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 318-353 4.65e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 4.65e-04
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 755494302 318 CNSYGrNCQNGGKCVEKHIGYTCDCtNSPYEGPFCK 353
Cdd:cd00054    5 CASGN-PCQNGGTCVNTVGSYRCSC-PPGYTGRNCE 38
DUF1566 pfam07603
Protein of unknown function (DUF1566); These proteins of unknown function are found in ...
 2-87 5.37e-03

Protein of unknown function (DUF1566); These proteins of unknown function are found in Leptospira interrogans and in several gamma proteobacteria.


Pssm-ID: 429556 [Multi-domain]  Cd Length: 117  Bit Score: 37.36  E-value: 5.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755494302    2 TVQHNNTELTWIQGSNTEKP--------YVMNLN---YGG-------SMEQLEALIDgsehceqevtyYCRRSHLLNT-- 61
Cdd:pfam07603   2 TVTDNLTGLMWQRCAEAGATcswqdalaYCAALNaagFAGysdwrlpTIRELLSLVD-----------YSRASPAINTta 70

                          90       100
                  ....*....|....*....|....*....
gi 755494302   62 -PDGAPFAWWTGRSNERHPY--WGGYFPG 87
Cdd:pfam07603  71 fPNTPPFYYWSSTTSAGNPDyaWAVNFAD 99
 
Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 177-296 2.14e-24

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 98.65  E-value: 2.14e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755494302  177 FKTTALSGVFLENLGVKN-FLRLEMSSpSEVIFAIDVGNGPMELLVqSPYPLNDNQWHYIQAERNIKETLLHVDNLPKSM 255
Cdd:pfam02210   1 FRTRQPNGLLLYAGGGGSdFLALELVN-GRLVLRYDLGSGPESLLS-SGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVS 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 755494302  256 RMASEEGHFlLQLNSQLFVGG--------TSSRQKGFLGCIRSLHLNGQ 296
Cdd:pfam02210  79 SLPPGESLL-LNLNGPLYLGGlppllllpALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 150-294 2.24e-24

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 99.41  E-value: 2.24e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755494302 150 AVSFSTEAaYLHIPTFHAE-FSADISFFFKTTALSGV--FLENLGVKNFLRLEMSSpSEVIFAIDvgNGPMELLVQSPYP 226
Cdd:cd00110    1 GVSFSGSS-YVRLPTLPAPrTRLSISFSFRTTSPNGLllYAGSQNGGDFLALELED-GRLVLRYD--LGSGSLVLSSKTP 76

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755494302 227 LNDNQWHYIQAERNIKETLLHVDNLPkSMRMASEEGHFLLQLNSQLFVGGT--------SSRQKGFLGCIRSLHLN 294
Cdd:cd00110   77 LNDGQWHSVSVERNGRSVTLSVDGER-VVESGSPGGSALLNLDGPLYLGGLpedlkspgLPVSPGFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
172-296 6.01e-23

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 94.71  E-value: 6.01e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755494302   172 DISFFFKTTALSGV--FLENLGVKNFLRLEMSSpSEVIFAIDVGNGPMELLVQsPYPLNDNQWHYIQAERNIKETLLHVD 249
Cdd:smart00282   1 SISFSFRTTSPNGLllYAGSKGGGDYLALELRD-GRLVLRYDLGSGPARLTSD-PTPLNDGQWHRVAVERNGRSVTLSVD 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 755494302   250 NLPkSMRMASEEGHFLLQLNSQLFVGGT--------SSRQKGFLGCIRSLHLNGQ 296
Cdd:smart00282  79 GGN-RVSGESPGGLTILNLDGPLYLGGLpedlklppLPVTPGFRGCIRNLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 402-530 4.58e-20

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 86.32  E-value: 4.58e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755494302  402 FMTAQAPTLLLYLNFSSQNFLAILLsRNGSLQIQYRLSKEESHVFTiSTENLANRRVHQVKMSRDGPELSIQMDQQ-LFS 480
Cdd:pfam02210   1 FRTRQPNGLLLYAGGGGSDFLALEL-VNGRLVLRYDLGSGPESLLS-SGKNLNDGQWHSVRVERNGNTLTLSVDGQtVVS 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 755494302  481 YNFPPEVE-FQTVRSLILGKVtetLGLDPEVAKANTLGFVGCLSSVQYNHI 530
Cdd:pfam02210  79 SLPPGESLlLNLNGPLYLGGL---PPLLLLPALPVRAGFVGCIRDVRVNGE 126
Laminin_G_1 pfam00054
Laminin G domain;
177-299 6.99e-15

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 71.58  E-value: 6.99e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755494302  177 FKTTALSGVFLENLGV--KNFLRLEMSSpSEVIFAIDVGNGPmeLLVQSPYPLNDNQWHYIQAERNIKETLLHVDNLPKS 254
Cdd:pfam00054   1 FRTTEPSGLLLYNGTQteRDFLALELRD-GRLEVSYDLGSGA--AVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEARP 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 755494302  255 MRMASEEGHFLLQLNSQLFVGGTSS---------RQKGFLGCIRSLHLNGQKVD 299
Cdd:pfam00054  78 TGESPLGATTDLDVDGPLYVGGLPSlgvkkrrlaISPSFDGCIRDVIVNGKPLD 131
LamG smart00282
Laminin G domain;
398-529 1.26e-12

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 65.44  E-value: 1.26e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755494302   398 ITLSFMTAQAPTLLLYLNFSSQN-FLAILLsRNGSLQIQYRLSKEESHVfTISTENLANRRVHQVKMSRDGPELSIQMDQ 476
Cdd:smart00282   2 ISFSFRTTSPNGLLLYAGSKGGGdYLALEL-RDGRLVLRYDLGSGPARL-TSDPTPLNDGQWHRVAVERNGRSVTLSVDG 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 755494302   477 QLFSY--NFPPEVEFQTVRSLILGKVTETLGLDPEVakaNTLGFVGCLSSVQYNH 529
Cdd:smart00282  80 GNRVSgeSPGGLTILNLDGPLYLGGLPEDLKLPPLP---VTPGFRGCIRNLKVNG 131
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 389-528 1.51e-10

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 59.74  E-value: 1.51e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755494302 389 KDTAPSKEAITLSFMTAQAPTLLLYL-NFSSQNFLAILLsRNGSLQIQYRLSKEeSHVFTiSTENLANRRVHQVKMSRDG 467
Cdd:cd00110   15 LPAPRTRLSISFSFRTTSPNGLLLYAgSQNGGDFLALEL-EDGRLVLRYDLGSG-SLVLS-SKTPLNDGQWHSVSVERNG 91

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755494302 468 PELSIQMDQQLF--SYNFPPEVEFQTVRSLILGKVTETLGLDPEVakaNTLGFVGCLSSVQYN 528
Cdd:cd00110   92 RSVTLSVDGERVveSGSPGGSALLNLDGPLYLGGLPEDLKSPGLP---VSPGFVGCIRDLKVN 151
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 318-351 2.31e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.90  E-value: 2.31e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 755494302  318 CNSYgrNCQNGGKCVEKHIGYTCDCTNsPYEGPF 351
Cdd:pfam00008   1 CAPN--PCSNGGTCVDTPGGYTCICPE-GYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 318-353 4.65e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 4.65e-04
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 755494302 318 CNSYGrNCQNGGKCVEKHIGYTCDCtNSPYEGPFCK 353
Cdd:cd00054    5 CASGN-PCQNGGTCVNTVGSYRCSC-PPGYTGRNCE 38
DUF1566 pfam07603
Protein of unknown function (DUF1566); These proteins of unknown function are found in ...
 2-87 5.37e-03

Protein of unknown function (DUF1566); These proteins of unknown function are found in Leptospira interrogans and in several gamma proteobacteria.


Pssm-ID: 429556 [Multi-domain]  Cd Length: 117  Bit Score: 37.36  E-value: 5.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755494302    2 TVQHNNTELTWIQGSNTEKP--------YVMNLN---YGG-------SMEQLEALIDgsehceqevtyYCRRSHLLNT-- 61
Cdd:pfam07603   2 TVTDNLTGLMWQRCAEAGATcswqdalaYCAALNaagFAGysdwrlpTIRELLSLVD-----------YSRASPAINTta 70

                          90       100
                  ....*....|....*....|....*....
gi 755494302   62 -PDGAPFAWWTGRSNERHPY--WGGYFPG 87
Cdd:pfam07603  71 fPNTPPFYYWSSTTSAGNPDyaWAVNFAD 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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