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Conserved domains on  [gi|755513648|ref|XP_011246500|]
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N-alpha-acetyltransferase 25, NatB auxiliary subunit isoform X1 [Mus musculus]

Protein Classification

MDM20/NAA25 family protein( domain architecture ID 10561161)

MDM20/NAA25 family protein similar to Caenorhabditis elegans N-terminal acetyltransferase B complex subunit NAA25 homolog, a non-catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of proteins beginning with Met-Asp or Met-Glu

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NatB_MDM20 pfam09797
N-acetyltransferase B complex (NatB) non catalytic subunit; This is the non-catalytic subunit ...
 235-630 9.60e-158

N-acetyltransferase B complex (NatB) non catalytic subunit; This is the non-catalytic subunit of the N-terminal acetyltransferase B complex (NatB). The NatB complex catalyzes the acetylation of the amino-terminal methionine residue of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met. In Saccharomyces cerevisiae this subunit is called MDM20 and in Schizosaccharomyces pombe it is called Arm1. NatB acetylates the Tpm1 protein and regulates and tropomyocin-actin interactions. This subunit is required by the NatB complex for the N-terminal acetylation of Tpm1.


:

Pssm-ID: 430834  Cd Length: 368  Bit Score: 467.93  E-value: 9.60e-158
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755513648  235 WQFYLTYFDSVFRLIEEawtppaegehslegevHCSAEDAVKFIEDRITEASQSSRHVRGPHLAKLELIRRLRSQGCNDE 314
Cdd:pfam09797   1 WSVWKLYIDSTFKLIEA----------------KESLEEAQKFIEELIKAEEAKSPKSRNPYLARLELISRLRKRSDDAE 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755513648  315 YKLGDPEELMFQYFKKFGDKPCCFTDLKVFVDLLPAAQCTQFINQLLgvvpLSTPTEDKLAlPADIRGLQQHLCVVQLTR 394
Cdd:pfam09797  65 EDLGPLVELILEYFDKFGSKPCCFDDLKPYLELLSDEQRKEFLEKVS----PSKSELDSLV-PGDEKQLRRHINALKLSR 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755513648  395 LLGLYHSMDKSQKLDVVKELMLRYQHGLEFGRSCLKTELQFSDYYCLLAVHVLIDVWREAGEETAVWQALTLLEEGLTHS 474
Cdd:pfam09797 140 CLGLHSKLSEEEKEALVTELLAIYRAGLRLGASLLTTELQPSDDLALLAAHALLDLYRLTGDLTYLIQAILLLEFLLTKS 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755513648  475 PSNAQFKLLLVRIYCVLGAFEPVVDLYSSLDAKHIQHDTIGYLLTRYAASLGQYAAASQSCNFALRFFHSNQKDTSEYII 554
Cdd:pfam09797 220 PHNFQLKLLLVRLYLLLGAGSLALDLYSKLDIKQIQLDTLGHLLFTRLSTLGPFSLALNLLEQALRFYRNNEKETPEMIS 299

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755513648  555 QAYKYGAFEKIPEFIAFRNRLNNSLHFAQVRTERMLLDLLLEANISIslaesikSMNLRPEEDDVPWEDLRDNRDL 630
Cdd:pfam09797 300 QAYEYGSYSKIEEFIEFRERLKNSLQRAMVRLERRRLDRLLGGDISD-------EMSLYPDEDRIDWSELSDNRDF 368
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 2-118 2.70e-10

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


:

Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 59.44  E-value: 2.70e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755513648   2 AIQQADKLLKKHKDLHCAKVLKAIGLQRTGKQEEAFTLAQEVAALEPTDDNSLQALTILYREMHRPELVTKLYEAAVKKV 81
Cdd:COG4783   23 AEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLD 102

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 755513648  82 PNSEEYHSHLFMAYARVGEYKKMQQAGMALYKIVPKN 118
Cdd:COG4783  103 PEHPEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
 
Name Accession Description Interval E-value
NatB_MDM20 pfam09797
N-acetyltransferase B complex (NatB) non catalytic subunit; This is the non-catalytic subunit ...
 235-630 9.60e-158

N-acetyltransferase B complex (NatB) non catalytic subunit; This is the non-catalytic subunit of the N-terminal acetyltransferase B complex (NatB). The NatB complex catalyzes the acetylation of the amino-terminal methionine residue of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met. In Saccharomyces cerevisiae this subunit is called MDM20 and in Schizosaccharomyces pombe it is called Arm1. NatB acetylates the Tpm1 protein and regulates and tropomyocin-actin interactions. This subunit is required by the NatB complex for the N-terminal acetylation of Tpm1.


Pssm-ID: 430834  Cd Length: 368  Bit Score: 467.93  E-value: 9.60e-158
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755513648  235 WQFYLTYFDSVFRLIEEawtppaegehslegevHCSAEDAVKFIEDRITEASQSSRHVRGPHLAKLELIRRLRSQGCNDE 314
Cdd:pfam09797   1 WSVWKLYIDSTFKLIEA----------------KESLEEAQKFIEELIKAEEAKSPKSRNPYLARLELISRLRKRSDDAE 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755513648  315 YKLGDPEELMFQYFKKFGDKPCCFTDLKVFVDLLPAAQCTQFINQLLgvvpLSTPTEDKLAlPADIRGLQQHLCVVQLTR 394
Cdd:pfam09797  65 EDLGPLVELILEYFDKFGSKPCCFDDLKPYLELLSDEQRKEFLEKVS----PSKSELDSLV-PGDEKQLRRHINALKLSR 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755513648  395 LLGLYHSMDKSQKLDVVKELMLRYQHGLEFGRSCLKTELQFSDYYCLLAVHVLIDVWREAGEETAVWQALTLLEEGLTHS 474
Cdd:pfam09797 140 CLGLHSKLSEEEKEALVTELLAIYRAGLRLGASLLTTELQPSDDLALLAAHALLDLYRLTGDLTYLIQAILLLEFLLTKS 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755513648  475 PSNAQFKLLLVRIYCVLGAFEPVVDLYSSLDAKHIQHDTIGYLLTRYAASLGQYAAASQSCNFALRFFHSNQKDTSEYII 554
Cdd:pfam09797 220 PHNFQLKLLLVRLYLLLGAGSLALDLYSKLDIKQIQLDTLGHLLFTRLSTLGPFSLALNLLEQALRFYRNNEKETPEMIS 299

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755513648  555 QAYKYGAFEKIPEFIAFRNRLNNSLHFAQVRTERMLLDLLLEANISIslaesikSMNLRPEEDDVPWEDLRDNRDL 630
Cdd:pfam09797 300 QAYEYGSYSKIEEFIEFRERLKNSLQRAMVRLERRRLDRLLGGDISD-------EMSLYPDEDRIDWSELSDNRDF 368
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 2-118 2.70e-10

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 59.44  E-value: 2.70e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755513648   2 AIQQADKLLKKHKDLHCAKVLKAIGLQRTGKQEEAFTLAQEVAALEPTDDNSLQALTILYREMHRPELVTKLYEAAVKKV 81
Cdd:COG4783   23 AEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLD 102

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 755513648  82 PNSEEYHSHLFMAYARVGEYKKMQQAGMALYKIVPKN 118
Cdd:COG4783  103 PEHPEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 417-533 4.16e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 40.10  E-value: 4.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755513648 417 RYQHGLEFGRSCLKTELQFSDYYCLLAvhvliDVWREAGEETavwQALTLLEEGLTHSPSNAQFKLLLVRIYCVLGAFEP 496
Cdd:COG2956  125 DWEKAIEVLERLLKLGPENAHAYCELA-----ELYLEQGDYD---EAIEALEKALKLDPDCARALLLLAELYLEQGDYEE 196

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 755513648 497 VVDLYSSLDAKHIQHDTIGYLLTRYAASLGQYAAASQ 533
Cdd:COG2956  197 AIAALERALEQDPDYLPALPRLAELYEKLGDPEEALE 233
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 2-185 7.76e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 40.07  E-value: 7.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755513648    2 AIQQADKLLKKHKDLHCAKVLKAIGLQRTGKQEEAFTLAQEVAALEPTDDNSLQAL-TILYREMHRPELVTKLyEAAVKK 80
Cdd:TIGR02917 178 ARALIDEVLTADPGNVDALLLKGDLLLSLGNIELALAAYRKAIALRPNNIAVLLALaTILIEAGEFEEAEKHA-DALLKK 256

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755513648   81 VPNSEEYHSHLFMAYARVGEYkkmQQAGMALYKIVPKNPYYFWSVMSLIMQSISARDenlsktmfLPLAERMVEKMVKED 160
Cdd:TIGR02917 257 APNSPLAHYLKALVDFQKKNY---EDARETLQDALKSAPEYLPALLLAGASEYQLGN--------LEQAYQYLNQILKYA 325

                         170       180
                  ....*....|....*....|....*
gi 755513648  161 KIEAEAeVELYYMILERLGKYQEAL 185
Cdd:TIGR02917 326 PNSHQA-RRLLASIQLRLGRVDEAI 349
 
Name Accession Description Interval E-value
NatB_MDM20 pfam09797
N-acetyltransferase B complex (NatB) non catalytic subunit; This is the non-catalytic subunit ...
 235-630 9.60e-158

N-acetyltransferase B complex (NatB) non catalytic subunit; This is the non-catalytic subunit of the N-terminal acetyltransferase B complex (NatB). The NatB complex catalyzes the acetylation of the amino-terminal methionine residue of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met. In Saccharomyces cerevisiae this subunit is called MDM20 and in Schizosaccharomyces pombe it is called Arm1. NatB acetylates the Tpm1 protein and regulates and tropomyocin-actin interactions. This subunit is required by the NatB complex for the N-terminal acetylation of Tpm1.


Pssm-ID: 430834  Cd Length: 368  Bit Score: 467.93  E-value: 9.60e-158
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755513648  235 WQFYLTYFDSVFRLIEEawtppaegehslegevHCSAEDAVKFIEDRITEASQSSRHVRGPHLAKLELIRRLRSQGCNDE 314
Cdd:pfam09797   1 WSVWKLYIDSTFKLIEA----------------KESLEEAQKFIEELIKAEEAKSPKSRNPYLARLELISRLRKRSDDAE 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755513648  315 YKLGDPEELMFQYFKKFGDKPCCFTDLKVFVDLLPAAQCTQFINQLLgvvpLSTPTEDKLAlPADIRGLQQHLCVVQLTR 394
Cdd:pfam09797  65 EDLGPLVELILEYFDKFGSKPCCFDDLKPYLELLSDEQRKEFLEKVS----PSKSELDSLV-PGDEKQLRRHINALKLSR 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755513648  395 LLGLYHSMDKSQKLDVVKELMLRYQHGLEFGRSCLKTELQFSDYYCLLAVHVLIDVWREAGEETAVWQALTLLEEGLTHS 474
Cdd:pfam09797 140 CLGLHSKLSEEEKEALVTELLAIYRAGLRLGASLLTTELQPSDDLALLAAHALLDLYRLTGDLTYLIQAILLLEFLLTKS 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755513648  475 PSNAQFKLLLVRIYCVLGAFEPVVDLYSSLDAKHIQHDTIGYLLTRYAASLGQYAAASQSCNFALRFFHSNQKDTSEYII 554
Cdd:pfam09797 220 PHNFQLKLLLVRLYLLLGAGSLALDLYSKLDIKQIQLDTLGHLLFTRLSTLGPFSLALNLLEQALRFYRNNEKETPEMIS 299

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755513648  555 QAYKYGAFEKIPEFIAFRNRLNNSLHFAQVRTERMLLDLLLEANISIslaesikSMNLRPEEDDVPWEDLRDNRDL 630
Cdd:pfam09797 300 QAYEYGSYSKIEEFIEFRERLKNSLQRAMVRLERRRLDRLLGGDISD-------EMSLYPDEDRIDWSELSDNRDF 368
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 2-118 2.70e-10

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 59.44  E-value: 2.70e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755513648   2 AIQQADKLLKKHKDLHCAKVLKAIGLQRTGKQEEAFTLAQEVAALEPTDDNSLQALTILYREMHRPELVTKLYEAAVKKV 81
Cdd:COG4783   23 AEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLD 102

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 755513648  82 PNSEEYHSHLFMAYARVGEYKKMQQAGMALYKIVPKN 118
Cdd:COG4783  103 PEHPEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 2-132 6.94e-09

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 59.62  E-value: 6.94e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755513648   2 AIQQADKLLKKHKDLHCAKVLKAIGLQRTGKQEEAFTLAQEVAALEPTDDNSLQALTILYREMHRPELVTKLYEAAVKKV 81
Cdd:COG3914   97 ALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELD 176

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 755513648  82 PNSEEYHSHLFMAYARVGEYKKMQQAGMALYKIVPKNPYYFWSVMSLIMQS 132
Cdd:COG3914  177 PDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNLLFALRQA 227
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 2-114 1.68e-08

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 58.47  E-value: 1.68e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755513648   2 AIQQADKLLKKHKDLHCAKVLKAIGLQRTGKQEEAFTLAQEVAALEPTDDNSLQALTILYREMHRPELVTKLYEAAVKKV 81
Cdd:COG3914  131 ALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELD 210

                         90       100       110
                 ....*....|....*....|....*....|...
gi 755513648  82 PNSEEYHSHLFMAYARVGEYKKMQQAGMALYKI 114
Cdd:COG3914  211 PDNADAHSNLLFALRQACDWEVYDRFEELLAAL 243
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 2-192 3.17e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 55.89  E-value: 3.17e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755513648   2 AIQQADKLLKKHKDLHCAKVLKAIGLQRTGKQEEAFTLAQEVAALEPTDDNSLQALTILYREMHRPELVTKLYEAAVKKV 81
Cdd:COG2956   61 AIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLG 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755513648  82 PNSEEYHSHLFMAYARVGEYKKMQQAGMALYKIVPKNPYYfwsvmSLIMQSISARDENLSKtmflplAERMVEKMVKEDK 161
Cdd:COG2956  141 PENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARA-----LLLLAELYLEQGDYEE------AIAALERALEQDP 209

                        170       180       190
                 ....*....|....*....|....*....|.
gi 755513648 162 IEAEAEVELYYmILERLGKYQEALDVIRGKL 192
Cdd:COG2956  210 DYLPALPRLAE-LYEKLGDPEEALELLRKAL 239
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 2-189 6.33e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 55.12  E-value: 6.33e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755513648   2 AIQQADKLLKKHKDLhcAKVLKAIG--LQRTGKQEEAFTLAQEVAALEPTDDNSLQALTILYREMHRPELVTKLYEAAVK 79
Cdd:COG2956   27 AIDLLEEALELDPET--VEAHLALGnlYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLE 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755513648  80 KVPNSEEYHSHLFMAYARVGEYKKMQQAGMALYKIVPKNPYYFwsvmsLIMQSISARDENLSKtmflplAERMVEKMVKE 159
Cdd:COG2956  105 LDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAY-----CELAELYLEQGDYDE------AIEALEKALKL 173

                        170       180       190
                 ....*....|....*....|....*....|
gi 755513648 160 DKIEAEAEVELyYMILERLGKYQEALDVIR 189
Cdd:COG2956  174 DPDCARALLLL-AELYLEQGDYEEAIAALE 202
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
2-128 1.08e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 51.16  E-value: 1.08e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755513648   2 AIQQADKLLKKHKDLHCAKVLKAIGLQRTGKQEEAFTLAQEVAALEPTDDNSLQALTILYREMHRPELVTKLYEAAVKKV 81
Cdd:COG0457   27 AIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALELD 106

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 755513648  82 PNSEEYHSHLFMAYARVGEYkkmQQAGMALYKIVPKNPYYFWSVMSL 128
Cdd:COG0457  107 PDDAEALYNLGLALLELGRY---DEAIEAYERALELDPDDADALYNL 150
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 2-119 1.25e-06

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 48.46  E-value: 1.25e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755513648   2 AIQQADKLLKKHKDLHCAKVLKAIGLQRTGKQEEAFTLAQEVAALEPTDDNSLQALTILYREMHRPELVTKLYEAAVKKV 81
Cdd:COG4235    2 AIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALD 81

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 755513648  82 PNSEEYHSHLFMAYARVGEYKKMQQAGMALYKIVPKNP 119
Cdd:COG4235   82 PDNPEALYLLGLAAFQQGDYAEAIAAWQKLLALLPADA 119
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
23-189 2.54e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 50.01  E-value: 2.54e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755513648  23 KAIGLQRTGKQEEAFTLAQEVAALEPTDDNSLQALTILYREMHRPELVTKLYEAAVKKVPNSEEYHSHLFMAYARVGEYk 102
Cdd:COG0457   14 LGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRY- 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755513648 103 kmQQAGMALYKIVPKNPYYF--WSVMSLIMQSISARDEnlsktmflplAERMVEKMVKEDKIEAEAEVELyYMILERLGK 180
Cdd:COG0457   93 --EEALEDYDKALELDPDDAeaLYNLGLALLELGRYDE----------AIEAYERALELDPDDADALYNL-GIALEKLGR 159


                 ....*....
gi 755513648 181 YQEALDVIR 189
Cdd:COG0457  160 YEEALELLE 168
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
2-103 6.16e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 48.85  E-value: 6.16e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755513648   2 AIQQADKLLKKHKDLHCAKVLKAIGLQRTGKQEEAFTLAQEVAALEPTDDNSLQALTILYREMHRPELVTKLYEAAVKKV 81
Cdd:COG0457   61 ALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELD 140

                         90       100
                 ....*....|....*....|..
gi 755513648  82 PNSEEYHSHLFMAYARVGEYKK 103
Cdd:COG0457  141 PDDADALYNLGIALEKLGRYEE 162
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 19-123 1.58e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 45.57  E-value: 1.58e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755513648  19 AKVLKAIGLQRTGKQEEAFTLAQEVAALEPTDDNSLQALTILYREMHRPELVTKLYEAAVKKVPNSEEYHSHLFMAYARV 98
Cdd:COG4783    6 ALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKA 85

                         90       100
                 ....*....|....*....|....*....
gi 755513648  99 GEYKKmqqaGMALYKIV----PKNPYYFW 123
Cdd:COG4783   86 GDYDE----ALALLEKAlkldPEHPEAYL 110
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 22-189 1.78e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 47.42  E-value: 1.78e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755513648  22 LKAIGLQRTGKQEEAFTLAQEVAALEPTDDNSLQALTILYREMHRPELVTKLYEAAVKKVPNSEEYHSHLFMAYARVGEY 101
Cdd:COG2956   13 FKGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755513648 102 KKMQQAGMALYKIVPKNPYYFWSVMslimqSISARDENLSKtmflplAERMVEKMVKEDKIEAEAEVELyYMILERLGKY 181
Cdd:COG2956   93 DRAEELLEKLLELDPDDAEALRLLA-----EIYEQEGDWEK------AIEVLERLLKLGPENAHAYCEL-AELYLEQGDY 160


                 ....*...
gi 755513648 182 QEALDVIR 189
Cdd:COG2956  161 DEAIEALE 168
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 2-123 2.59e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 47.03  E-value: 2.59e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755513648   2 AIQQADKLLKKHKDLHCAKVLKAIGLQRTGKQEEAFTLAQEVAALEPTDDNSLQALTILYREMHRPELVTKLYEAAVKKV 81
Cdd:COG2956  129 AIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQD 208

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 755513648  82 PNSEEYHSHLFMAYARVGEYKKMQQAGMALYKIVPKNPYYFW 123
Cdd:COG2956  209 PDYLPALPRLAELYEKLGDPEEALELLRKALELDPSDDLLLA 250
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 27-107 3.88e-05

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 44.95  E-value: 3.88e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755513648  27 LQRTGKQEEAFTLAQEVAALEPTDDNSLQALTILYREMHRPELVTKLYEAAVKKVPNSEEYHSHLFMAYARVGEYKKMQQ 106
Cdd:COG5010   64 YNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKA 143


                 .
gi 755513648 107 A 107
Cdd:COG5010  144 A 144
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 35-123 2.85e-04

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 41.92  E-value: 2.85e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755513648  35 EAFTLAQEVAALEPTDDNSLQALTILYREMHRPELVTKLYEAAVKKVPNSEEYHSHLFMAYARVGEYKKMQQAGMALYKI 114
Cdd:COG4235    1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALAL 80


                 ....*....
gi 755513648 115 VPKNPYYFW 123
Cdd:COG4235   81 DPDNPEALY 89
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
27-117 6.29e-04

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 39.77  E-value: 6.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755513648  27 LQRTGKQEEAFTLAQEVAALEPTDDNSLQALTILYREMHRPELVTKlYEAAVKKVPNSEEYHSHLFMAYARVGEYKKMQQ 106
Cdd:COG3063    2 YLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELLLELGDYDEALA 80

                         90
                 ....*....|.
gi 755513648 107 AGMALYKIVPK 117
Cdd:COG3063   81 YLERALELDPS 91
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
45-189 1.31e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 41.53  E-value: 1.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755513648  45 ALEPTDDNSLQALTILYREMHRPELVTKLYEAAVKKVPNSEEYHSHLFMAYARVGEYKKMQQAGMALYKIVPKNPYYfWS 124
Cdd:COG0457    2 ELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEA-LN 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755513648 125 VMSLIMQSISARDEnlsktmflplAERMVEKMVKEDKIEAEAeveLYY--MILERLGKYQEALDVIR 189
Cdd:COG0457   81 NLGLALQALGRYEE----------ALEDYDKALELDPDDAEA---LYNlgLALLELGRYDEAIEAYE 134
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 2-87 2.54e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 38.83  E-value: 2.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755513648   2 AIQQADKLLKKHKDlhcAKVLKAIGLQRTGKQEEAFTLAQEVAALEPTDDNSLQALTILYREMHRPELVTKLYEAAVKKV 81
Cdd:COG4235   39 AYEKALRLDPDNAD---ALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAAFQQGDYAEAIAAWQKLLALL 115


                 ....*.
gi 755513648  82 PNSEEY 87
Cdd:COG4235  116 PADAPA 121
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 19-119 2.86e-03

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 39.56  E-value: 2.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755513648  19 AKVLKAIGLQRTGKQEEAFTLAQEVAALEPTDDNSLQALTILYREMHRPELVTKLYEAAVKKVPNSEEYHSHLFMAYARV 98
Cdd:COG5010   22 TLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRS 101

                         90       100
                 ....*....|....*....|.
gi 755513648  99 GEYKKMQQAGMALYKIVPKNP 119
Cdd:COG5010  102 GDKDEAKEYYEKALALSPDNP 122
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 417-533 4.16e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 40.10  E-value: 4.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755513648 417 RYQHGLEFGRSCLKTELQFSDYYCLLAvhvliDVWREAGEETavwQALTLLEEGLTHSPSNAQFKLLLVRIYCVLGAFEP 496
Cdd:COG2956  125 DWEKAIEVLERLLKLGPENAHAYCELA-----ELYLEQGDYD---EAIEALEKALKLDPDCARALLLLAELYLEQGDYEE 196

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 755513648 497 VVDLYSSLDAKHIQHDTIGYLLTRYAASLGQYAAASQ 533
Cdd:COG2956  197 AIAALERALEQDPDYLPALPRLAELYEKLGDPEEALE 233
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 417-540 4.42e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 38.63  E-value: 4.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755513648 417 RYQHGLEFGRSCLKTELQFSDYYCLLAvhvliDVWREAGEETavwQALTLLEEGLTHSPSNAQFKLLLVRIYCVLGAFEP 496
Cdd:COG4783   19 DYDEAEALLEKALELDPDNPEAFALLG-----EILLQLGDLD---EAIVLLHEALELDPDEPEARLNLGLALLKAGDYDE 90

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 755513648 497 VVDLYSSLDAKHIQHDTIGYLLTRYAASLGQYAAASQSCNFALR 540
Cdd:COG4783   91 ALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALE 134
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 2-185 7.76e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 40.07  E-value: 7.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755513648    2 AIQQADKLLKKHKDLHCAKVLKAIGLQRTGKQEEAFTLAQEVAALEPTDDNSLQAL-TILYREMHRPELVTKLyEAAVKK 80
Cdd:TIGR02917 178 ARALIDEVLTADPGNVDALLLKGDLLLSLGNIELALAAYRKAIALRPNNIAVLLALaTILIEAGEFEEAEKHA-DALLKK 256

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755513648   81 VPNSEEYHSHLFMAYARVGEYkkmQQAGMALYKIVPKNPYYFWSVMSLIMQSISARDenlsktmfLPLAERMVEKMVKED 160
Cdd:TIGR02917 257 APNSPLAHYLKALVDFQKKNY---EDARETLQDALKSAPEYLPALLLAGASEYQLGN--------LEQAYQYLNQILKYA 325

                         170       180
                  ....*....|....*....|....*
gi 755513648  161 KIEAEAeVELYYMILERLGKYQEAL 185
Cdd:TIGR02917 326 PNSHQA-RRLLASIQLRLGRVDEAI 349
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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