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Conserved domains on  [gi|755526749|ref|XP_011246679|]
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podocan-like protein 1 isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK15370 super family cl33128
type III secretion system effector E3 ubiquitin transferase SlrP;
166-421 3.99e-22

type III secretion system effector E3 ubiquitin transferase SlrP;


The actual alignment was detected with superfamily member PRK15370:

Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 100.54  E-value: 3.99e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 166 SVYLHNNRLRNtgLPPNtFHGSevITTLSLSSNQLSYLPPSLPASLERLHLQNNLISKVPRgalslqtHLRelylqhnql 245
Cdd:PRK15370 203 TLILDNNELKS--LPEN-LQGN--IKTLYANSNQLTSIPATLPDTIQEMELSINRITELPE-------RLP--------- 261

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 246 tdsgldattfsklSSLEYLDLSHNQLATVPEGLPGTLTILHLGRNCIRHVEAvrlHKARGLRYLLLQHNKLgaSALPKgT 325
Cdd:PRK15370 262 -------------SALQSLDLFHNKISCLPENLPEELRYLSVYDNSIRTLPA---HLPSGITHLNVQSNSL--TALPE-T 322

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 326 LRPlrALHTLHLYGNKLERVPPALPRHLQALVMPHNHVAALGArdlVSARALAELNLAYNSLASAHVH-PSAFRRLRALR 404
Cdd:PRK15370 323 LPP--GLKTLEAGENALTSLPASLPPELQVLDVSKNQITVLPE---TLPPTITTLDVSRNALTNLPENlPAALQIMQASR 397

                        250
                 ....*....|....*..
gi 755526749 405 sldlagNQLTRLPEGLP 421
Cdd:PRK15370 398 ------NNLVRLPESLP 408
LRR_8 pfam13855
Leucine rich repeat;
401-458 1.08e-08

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 51.37  E-value: 1.08e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755526749  401 RALRSLDLAGNQLTRLPEGLPASLRSLR---LQRNQLRTLEPEQLAGLNKLRELNLAHNRL 458
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKvldLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 71-226 1.15e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 49.40  E-value: 1.15e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749  71 HLSLQNNQLRELPYneLSRLSGLRTLDLHSNLITS-EGLpdeafESLNQLENFYVAHNKLSVAPQFL--PRS-------L 140
Cdd:cd21340   50 HLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVvEGL-----ENLTNLEELHIENQRLPPGEKLTfdPRSlaalsnsL 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 141 RVADLAANEVVEIFPLtfgekpalrsVYLHNnrlrntglppntfhgsevITTLSLSSNQLSYLPPSLPA-----SLERLH 215
Cdd:cd21340  123 RVLNISGNNIDSLEPL----------APLRN------------------LEQLDASNNQISDLEELLDLlsswpSLRELD 174

                        170
                 ....*....|.
gi 755526749 216 LQNNLISKVPR 226
Cdd:cd21340  175 LTGNPVCKKPK 185
 
Name Accession Description Interval E-value
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
166-421 3.99e-22

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 100.54  E-value: 3.99e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 166 SVYLHNNRLRNtgLPPNtFHGSevITTLSLSSNQLSYLPPSLPASLERLHLQNNLISKVPRgalslqtHLRelylqhnql 245
Cdd:PRK15370 203 TLILDNNELKS--LPEN-LQGN--IKTLYANSNQLTSIPATLPDTIQEMELSINRITELPE-------RLP--------- 261

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 246 tdsgldattfsklSSLEYLDLSHNQLATVPEGLPGTLTILHLGRNCIRHVEAvrlHKARGLRYLLLQHNKLgaSALPKgT 325
Cdd:PRK15370 262 -------------SALQSLDLFHNKISCLPENLPEELRYLSVYDNSIRTLPA---HLPSGITHLNVQSNSL--TALPE-T 322

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 326 LRPlrALHTLHLYGNKLERVPPALPRHLQALVMPHNHVAALGArdlVSARALAELNLAYNSLASAHVH-PSAFRRLRALR 404
Cdd:PRK15370 323 LPP--GLKTLEAGENALTSLPASLPPELQVLDVSKNQITVLPE---TLPPTITTLDVSRNALTNLPENlPAALQIMQASR 397

                        250
                 ....*....|....*..
gi 755526749 405 sldlagNQLTRLPEGLP 421
Cdd:PRK15370 398 ------NNLVRLPESLP 408
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
70-343 4.84e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 92.30  E-value: 4.84e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749  70 RHLSLQNNqlrelpyNELSRLSGLRTLDLHSNLITSegLPDEaFESLNQLENFYVAHNKLSVapqflprslrvadlaane 149
Cdd:COG4886   99 TELDLSGN-------EELSNLTNLESLDLSGNQLTD--LPEE-LANLTNLKELDLSNNQLTD------------------ 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 150 vveiFPLTFGEKPALRSVYLHNNRLrnTGLpPNTFHGSEVITTLSLSSNQLSYLPPSL--PASLERLHLQNNLISKVPRg 227
Cdd:COG4886  151 ----LPEPLGNLTNLKSLDLSNNQL--TDL-PEELGNLTNLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLTDLPE- 222

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 228 ALSLQTHLRELYLQHNQLTdsglDATTFSKLSSLEYLDLSHNQLATVPEGLPGT-LTILHLGRNCIRHVEAVRLHKARGL 306
Cdd:COG4886  223 PLANLTNLETLDLSNNQLT----DLPELGNLTNLEELDLSNNQLTDLPPLANLTnLKTLDLSNNQLTDLKLKELELLLGL 298

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 755526749 307 RYLLLQHNKLGASALPKGTLRPLRALHTLHLYGNKLE 343
Cdd:COG4886  299 NSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLV 335
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 190-417 6.09e-16

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 76.75  E-value: 6.09e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 190 ITTLSLSSNQLSYLP-PSLPASLERLHLQNNLISKVPrgALSLQTHLRELYLQHNQLTdsgldattfsklsSLEYLDLSH 268
Cdd:cd21340    4 ITHLYLNDKNITKIDnLSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIE-------------KIENLENLV 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 269 NqlatvpeglpgtLTILHLGRNCIRHVEAvrLHKARGLRYLLLQHNKLGAsalpkgtlrplralhtlhlyGNKLE---RV 345
Cdd:cd21340   69 N------------LKKLYLGGNRISVVEG--LENLTNLEELHIENQRLPP--------------------GEKLTfdpRS 114

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755526749 346 PPALPRHLQALVMPHNHVAALgaRDLVSARALAELNLAYNSLASAHVHPSAFRRLRALRSLDLAGNQLTRLP 417
Cdd:cd21340  115 LAALSNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEELLDLLSSWPSLRELDLTGNPVCKKP 184
LRR_8 pfam13855
Leucine rich repeat;
210-271 1.22e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.07  E-value: 1.22e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755526749  210 SLERLHLQNNLISKVPRGALSLQTHLRELYLQHNQLTdsGLDATTFSKLSSLEYLDLSHNQL 271
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT--TLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
401-458 1.08e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 51.37  E-value: 1.08e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755526749  401 RALRSLDLAGNQLTRLPEGLPASLRSLR---LQRNQLRTLEPEQLAGLNKLRELNLAHNRL 458
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKvldLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 71-226 1.15e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 49.40  E-value: 1.15e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749  71 HLSLQNNQLRELPYneLSRLSGLRTLDLHSNLITS-EGLpdeafESLNQLENFYVAHNKLSVAPQFL--PRS-------L 140
Cdd:cd21340   50 HLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVvEGL-----ENLTNLEELHIENQRLPPGEKLTfdPRSlaalsnsL 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 141 RVADLAANEVVEIFPLtfgekpalrsVYLHNnrlrntglppntfhgsevITTLSLSSNQLSYLPPSLPA-----SLERLH 215
Cdd:cd21340  123 RVLNISGNNIDSLEPL----------APLRN------------------LEQLDASNNQISDLEELLDLlsswpSLRELD 174

                        170
                 ....*....|.
gi 755526749 216 LQNNLISKVPR 226
Cdd:cd21340  175 LTGNPVCKKPK 185
LRR_8 pfam13855
Leucine rich repeat;
70-129 5.12e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.97  E-value: 5.12e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749   70 RHLSLQNNQLRELPYNELSRLSGLRTLDLHSNLITSegLPDEAFESLNQLENFYVAHNKL 129
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT--LSPGAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 394-458 2.96e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 40.18  E-value: 2.96e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755526749 394 PSAFRRLRALRSLDLAGNQLT-RLPE--GLPASLRSLRLQRNQLRTLEPEQLAGLNKLRELNLAHNRL 458
Cdd:PLN03150 435 PNDISKLRHLQSINLSGNSIRgNIPPslGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSL 502
 
Name Accession Description Interval E-value
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
166-421 3.99e-22

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 100.54  E-value: 3.99e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 166 SVYLHNNRLRNtgLPPNtFHGSevITTLSLSSNQLSYLPPSLPASLERLHLQNNLISKVPRgalslqtHLRelylqhnql 245
Cdd:PRK15370 203 TLILDNNELKS--LPEN-LQGN--IKTLYANSNQLTSIPATLPDTIQEMELSINRITELPE-------RLP--------- 261

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 246 tdsgldattfsklSSLEYLDLSHNQLATVPEGLPGTLTILHLGRNCIRHVEAvrlHKARGLRYLLLQHNKLgaSALPKgT 325
Cdd:PRK15370 262 -------------SALQSLDLFHNKISCLPENLPEELRYLSVYDNSIRTLPA---HLPSGITHLNVQSNSL--TALPE-T 322

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 326 LRPlrALHTLHLYGNKLERVPPALPRHLQALVMPHNHVAALGArdlVSARALAELNLAYNSLASAHVH-PSAFRRLRALR 404
Cdd:PRK15370 323 LPP--GLKTLEAGENALTSLPASLPPELQVLDVSKNQITVLPE---TLPPTITTLDVSRNALTNLPENlPAALQIMQASR 397

                        250
                 ....*....|....*..
gi 755526749 405 sldlagNQLTRLPEGLP 421
Cdd:PRK15370 398 ------NNLVRLPESLP 408
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 62-465 1.52e-20

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 95.69  E-value: 1.52e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749  62 PDNI---TRAARHLSLQNNQLRelpyNELSR--LSGLRTLDLHSNLITSEgLPDE--AFESLNQLE---NFYVAHNKLSV 131
Cdd:PLN00113 110 PDDIfttSSSLRYLNLSNNNFT----GSIPRgsIPNLETLDLSNNMLSGE-IPNDigSFSSLKVLDlggNVLVGKIPNSL 184

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 132 AP----QFL-----------PR------------------------------SLRVADLAANEVVEIFPLTFGEKPALRS 166
Cdd:PLN00113 185 TNltslEFLtlasnqlvgqiPRelgqmkslkwiylgynnlsgeipyeiggltSLNHLDLVYNNLTGPIPSSLGNLKNLQY 264

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 167 VYLHNNRLrnTGLPPNTFHGSEVITTLSLSSNQLSYLPPSLPA---SLERLHL-QNNLISKVPRGALSLqTHLRELYLQH 242
Cdd:PLN00113 265 LFLYQNKL--SGPIPPSIFSLQKLISLDLSDNSLSGEIPELVIqlqNLEILHLfSNNFTGKIPVALTSL-PRLQVLQLWS 341

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 243 NQLtdSGLDATTFSKLSSLEYLDLSHNQLA-TVPEGL--PGTLTILHLGRNCIRHVEAVRLHKARGLRYLLLQHNKLgAS 319
Cdd:PLN00113 342 NKF--SGEIPKNLGKHNNLTVLDLSTNNLTgEIPEGLcsSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSF-SG 418

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 320 ALPKGTLRpLRALHTLHLYGNKL----ERVPPALPRhLQALVMPHNHVAAlGARDLVSARALAELNLAYNSLASAhvHPS 395
Cdd:PLN00113 419 ELPSEFTK-LPLVYFLDISNNNLqgriNSRKWDMPS-LQMLSLARNKFFG-GLPDSFGSKRLENLDLSRNQFSGA--VPR 493

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755526749 396 AFRRLRALRSLDLAGNQLT-RLPEGLPA--SLRSLRLQRNQLRTLEPEQLAGLNKLRELNLAHNRLRvGDIGP 465
Cdd:PLN00113 494 KLGSLSELMQLKLSENKLSgEIPDELSSckKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLS-GEIPK 565
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
56-279 1.78e-20

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 95.15  E-value: 1.78e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749  56 LDLRIFPDNITRAARHLSLQNNQLRELPYNelsrLSG-LRTLDLHSNLITS--EGLPD-------------EAFESL-NQ 118
Cdd:PRK15370 188 LGLTTIPACIPEQITTLILDNNELKSLPEN----LQGnIKTLYANSNQLTSipATLPDtiqemelsinritELPERLpSA 263

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 119 LENFYVAHNKLSVAPQFLPRSLRVADLAANEVVEIfpltfgekPA-LRSVYLHNNRLRNT------GLPPNtfhgsevIT 191
Cdd:PRK15370 264 LQSLDLFHNKISCLPENLPEELRYLSVYDNSIRTL--------PAhLPSGITHLNVQSNSltalpeTLPPG-------LK 328

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 192 TLSLSSNQLSYLPPSLPASLERLHLQNNLISKVPRgalSLQTHLRELYLQHNQLTD--SGLDAttfsklsSLEYLDLSHN 269
Cdd:PRK15370 329 TLEAGENALTSLPASLPPELQVLDVSKNQITVLPE---TLPPTITTLDVSRNALTNlpENLPA-------ALQIMQASRN 398

                        250
                 ....*....|
gi 755526749 270 QLATVPEGLP 279
Cdd:PRK15370 399 NLVRLPESLP 408
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 72-458 4.64e-20

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 94.14  E-value: 4.64e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749  72 LSLQNNQLRELPYNELSRLSGLRTLDLHSNLIT-------------------SEGLPDEAFESLNQLENF---YVAHNKL 129
Cdd:PLN00113 145 LDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVgkipnsltnltslefltlaSNQLVGQIPRELGQMKSLkwiYLGYNNL 224

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 130 SVA-PQFLPR--SLRVADLAANEVVEIFPLTFGEKPALRSVYLHNNRLrnTGLPPNTFHGSEVITTLSLSSNQLSYLPPS 206
Cdd:PLN00113 225 SGEiPYEIGGltSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKL--SGPIPPSIFSLQKLISLDLSDNSLSGEIPE 302

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 207 LPA---SLERLHL-QNNLISKVPRGALSLqTHLRELYLQHNQLtdSGLDATTFSKLSSLEYLDLSHNQLA-TVPEGL--P 279
Cdd:PLN00113 303 LVIqlqNLEILHLfSNNFTGKIPVALTSL-PRLQVLQLWSNKF--SGEIPKNLGKHNNLTVLDLSTNNLTgEIPEGLcsS 379

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 280 GTLTILHLGRNCIRHVEAVRLHKARGLRYLLLQHNKLgASALPKG-TLRPL----------------------RALHTLH 336
Cdd:PLN00113 380 GNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSF-SGELPSEfTKLPLvyfldisnnnlqgrinsrkwdmPSLQMLS 458

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 337 LYGNKLERVPPALPR--HLQALVMPHNHVAALGARDLVSARALAELNLAYNSLASahVHPSAFRRLRALRSLDLAGNQLT 414
Cdd:PLN00113 459 LARNKFFGGLPDSFGskRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSG--EIPDELSSCKKLVSLDLSHNQLS 536

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|
gi 755526749 415 rlpEGLPAS------LRSLRLQRNQLRTLEPEQLAGLNKLRELNLAHNRL 458
Cdd:PLN00113 537 ---GQIPASfsempvLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHL 583
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
191-458 4.81e-20

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 93.99  E-value: 4.81e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 191 TTLSLSSNQLSYLPPSLPASLERLHLQNNLISKVPRgalSLQTHLRELYLQHNQLTdsgldattfsklssleyldlshnq 270
Cdd:PRK15370 181 TELRLKILGLTTIPACIPEQITTLILDNNELKSLPE---NLQGNIKTLYANSNQLT------------------------ 233

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 271 laTVPEGLPGTLTILHLGRNCIRHVEAvrlHKARGLRYLLLQHNKLgaSALPKGTLRPLRalhTLHLYGNKLERVPPALP 350
Cdd:PRK15370 234 --SIPATLPDTIQEMELSINRITELPE---RLPSALQSLDLFHNKI--SCLPENLPEELR---YLSVYDNSIRTLPAHLP 303

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 351 RHLQALVMPHNHVAALGARDLVSARALAELNLAYNSLaSAHVHPsafrrlrALRSLDLAGNQLTRLPEGLPASLRSLRLQ 430
Cdd:PRK15370 304 SGITHLNVQSNSLTALPETLPPGLKTLEAGENALTSL-PASLPP-------ELQVLDVSKNQITVLPETLPPTITTLDVS 375

                        250       260
                 ....*....|....*....|....*...
gi 755526749 431 RNQLRTLePEQLAGlnKLRELNLAHNRL 458
Cdd:PRK15370 376 RNALTNL-PENLPA--ALQIMQASRNNL 400
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
70-343 4.84e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 92.30  E-value: 4.84e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749  70 RHLSLQNNqlrelpyNELSRLSGLRTLDLHSNLITSegLPDEaFESLNQLENFYVAHNKLSVapqflprslrvadlaane 149
Cdd:COG4886   99 TELDLSGN-------EELSNLTNLESLDLSGNQLTD--LPEE-LANLTNLKELDLSNNQLTD------------------ 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 150 vveiFPLTFGEKPALRSVYLHNNRLrnTGLpPNTFHGSEVITTLSLSSNQLSYLPPSL--PASLERLHLQNNLISKVPRg 227
Cdd:COG4886  151 ----LPEPLGNLTNLKSLDLSNNQL--TDL-PEELGNLTNLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLTDLPE- 222

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 228 ALSLQTHLRELYLQHNQLTdsglDATTFSKLSSLEYLDLSHNQLATVPEGLPGT-LTILHLGRNCIRHVEAVRLHKARGL 306
Cdd:COG4886  223 PLANLTNLETLDLSNNQLT----DLPELGNLTNLEELDLSNNQLTDLPPLANLTnLKTLDLSNNQLTDLKLKELELLLGL 298

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 755526749 307 RYLLLQHNKLGASALPKGTLRPLRALHTLHLYGNKLE 343
Cdd:COG4886  299 NSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLV 335
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
187-475 8.38e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 91.53  E-value: 8.38e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 187 SEVITTLSLSSNQLSYLPPSLPASLERLHLQNNLISKVPRGALSLQTHLRELYLQHNQltdsgldatTFSKLSSLEYLDL 266
Cdd:COG4886   50 TLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE---------ELSNLTNLESLDL 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 267 SHNQLATVPEGLPG--TLTILHLGRNCIRHVEAVrLHKARGLRYLLLQHNKLgaSALPKGtLRPLRALHTLHLYGNKLER 344
Cdd:COG4886  121 SGNQLTDLPEELANltNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQL--TDLPEE-LGNLTNLKELDLSNNQITD 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 345 VPPAL--PRHLQALVMPHNHVAALGArDLVSARALAELNLAYNSLASAhvhpSAFRRLRALRSLDLAGNQLTRLPEGLP- 421
Cdd:COG4886  197 LPEPLgnLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDL----PELGNLTNLEELDLSNNQLTDLPPLANl 271

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 755526749 422 ASLRSLRLQRNQLRTLEPEQLAGLNKLRELNLAHNRLRVGDIGPGTWHELQALK 475
Cdd:COG4886  272 TNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLL 325
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
187-458 4.58e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 89.61  E-value: 4.58e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 187 SEVITTLSLSSNQLSYLPPSLPASLERLHLQNNLISKVPRGALSLQTHLRELYLQHNQLTDSGLDATTFSKLSSLEYLDL 266
Cdd:COG4886   24 LILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDL 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 267 SHNQlatvPEGLPGTLTILHLGRNCIRHVEAvRLHKARGLRYLLLQHNKLgaSALPKgTLRPLRALHTLHLYGNKLERVP 346
Cdd:COG4886  104 SGNE----ELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQL--TDLPE-PLGNLTNLKSLDLSNNQLTDLP 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 347 PALPR--HLQALVMPHNHVAALGArDLVSARALAELNLAYNSLASAhvhPSAFRRLRALRSLDLAGNQLTRLPE--GLPa 422
Cdd:COG4886  176 EELGNltNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDL---PEPLANLTNLETLDLSNNQLTDLPElgNLT- 250

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 755526749 423 SLRSLRLQRNQLRTLEPeqLAGLNKLRELNLAHNRL 458
Cdd:COG4886  251 NLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQL 284
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 190-417 6.09e-16

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 76.75  E-value: 6.09e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 190 ITTLSLSSNQLSYLP-PSLPASLERLHLQNNLISKVPrgALSLQTHLRELYLQHNQLTdsgldattfsklsSLEYLDLSH 268
Cdd:cd21340    4 ITHLYLNDKNITKIDnLSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIE-------------KIENLENLV 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 269 NqlatvpeglpgtLTILHLGRNCIRHVEAvrLHKARGLRYLLLQHNKLGAsalpkgtlrplralhtlhlyGNKLE---RV 345
Cdd:cd21340   69 N------------LKKLYLGGNRISVVEG--LENLTNLEELHIENQRLPP--------------------GEKLTfdpRS 114

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755526749 346 PPALPRHLQALVMPHNHVAALgaRDLVSARALAELNLAYNSLASAHVHPSAFRRLRALRSLDLAGNQLTRLP 417
Cdd:cd21340  115 LAALSNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEELLDLLSSWPSLRELDLTGNPVCKKP 184
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
70-326 3.90e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 77.28  E-value: 3.90e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749  70 RHLSLQNNQLRELPyNELSRLSGLRTLDLHSNLITSegLPDEaFESLNQLENFYVAHNKLSVAPQFL--PRSLRVADLAA 147
Cdd:COG4886  139 KELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTD--LPEE-LGNLTNLKELDLSNNQITDLPEPLgnLTNLEELDLSG 214

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 148 NEVVEIfPLTFGEKPALRSVYLHNNRLrnTGLPpnTFHGSEVITTLSLSSNQLSYLPPSLP-ASLERLHLQNNLISKVPR 226
Cdd:COG4886  215 NQLTDL-PEPLANLTNLETLDLSNNQL--TDLP--ELGNLTNLEELDLSNNQLTDLPPLANlTNLKTLDLSNNQLTDLKL 289

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 227 GALSLQTHLRELYLQHNQLTDSGLDATTFSKLSSLEYLDLSHNQLATVPEGLPGTLTILHLGRNCIRHVEAVRLHKARGL 306
Cdd:COG4886  290 KELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTL 369

                        250       260
                 ....*....|....*....|
gi 755526749 307 RYLLLQHNKLGASALPKGTL 326
Cdd:COG4886  370 GLLGLLEATLLTLALLLLTL 389
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 138-459 4.95e-14

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 74.06  E-value: 4.95e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 138 RSLRVADLAANEVVEIFPLTFGEKPALRSVYLHNNRLRNTGLPPNTFHGSEVITTLSLSSNQLSY-LPPSLPASLERLhl 216
Cdd:COG5238   64 RFEGQGDPGLNPVALEKAAEAFPTQLLVVDWEGAEEVSPVALAETATAVATPPPDLRRIMAKTLEdSLILYLALPRRI-- 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 217 qnNLISKVPRGALSLQTHLRelYLQHNQLTDSGLDATTFSKLSSLEYLDLSHNQLATvpEGL---------PGTLTILHL 287
Cdd:COG5238  142 --NLIQVLKDPLGGNAVHLL--GLAARLGLLAAISMAKALQNNSVETVYLGCNQIGD--EGIeelaealtqNTTVTTLWL 215

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 288 GRNCIRHVEAVRLHKA----RGLRYLLLQHNKL---GASALPKgTLRPLRALHTLHLYGNKL-----ERVPPALPR--HL 353
Cdd:COG5238  216 KRNPIGDEGAEILAEAlkgnKSLTTLDLSNNQIgdeGVIALAE-ALKNNTTVETLYLSGNQIgaegaIALAKALQGntTL 294

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 354 QALVMPHNHVAALGARDLVSA----RALAELNLAYNSLASAHVHP--SAFRRLRALRSLDLAGNQLT--------RLPEG 419
Cdd:COG5238  295 TSLDLSVNRIGDEGAIALAEGlqgnKTLHTLNLAYNGIGAQGAIAlaKALQENTTLHSLDLSDNQIGdegaialaKYLEG 374

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 755526749 420 LPaSLRSLRLQRNQLRTLEPEQLAGL---NKLRELNLAHNRLR 459
Cdd:COG5238  375 NT-TLRELNLGKNNIGKQGAEALIDAlqtNRLHTLILDGNLIG 416
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 152-458 9.48e-14

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 74.11  E-value: 9.48e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 152 EIFPLTFGeKPALRSVYLHNNRLrNTGLPPNTFHGSEVITTLSLSSNQLS-YLPPSLPASLERLHLQNNLIS-KVPRgAL 229
Cdd:PLN00113  84 KISSAIFR-LPYIQTINLSNNQL-SGPIPDDIFTTSSSLRYLNLSNNNFTgSIPRGSIPNLETLDLSNNMLSgEIPN-DI 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 230 SLQTHLRELYLQHNQLTdsGLDATTFSKLSSLEYLDLSHNQL-ATVPE--GLPGTLTILHLGRN--------------CI 292
Cdd:PLN00113 161 GSFSSLKVLDLGGNVLV--GKIPNSLTNLTSLEFLTLASNQLvGQIPRelGQMKSLKWIYLGYNnlsgeipyeiggltSL 238

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 293 RHVEAV----------RLHKARGLRYLLLQHNKLgASALPKgTLRPLRALHTLHLYGNKLERVPPALPRHLQALVMPH-- 360
Cdd:PLN00113 239 NHLDLVynnltgpipsSLGNLKNLQYLFLYQNKL-SGPIPP-SIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHlf 316

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 361 -NHVAALGARDLVSARALAELNLAYNSLASAhvHPSAFRRLRALRSLDLAGNQLT-RLPEGLPAS--LRSLRLQRNQLRT 436
Cdd:PLN00113 317 sNNFTGKIPVALTSLPRLQVLQLWSNKFSGE--IPKNLGKHNNLTVLDLSTNNLTgEIPEGLCSSgnLFKLILFSNSLEG 394

                        330       340
                 ....*....|....*....|..
gi 755526749 437 LEPEQLAGLNKLRELNLAHNRL 458
Cdd:PLN00113 395 EIPKSLGACRSLRRVRLQDNSF 416
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
70-300 3.46e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.50  E-value: 3.46e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749  70 RHLSLQNNQLRELPyNELSRLSGLRTLDLHSNLITSegLPDEaFESLNQLENFYVAHNKLSVAPQFLPR--SLRVADLAA 147
Cdd:COG4886  162 KSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITD--LPEP-LGNLTNLEELDLSGNQLTDLPEPLANltNLETLDLSN 237

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 148 NEVVEIFPLtfGEKPALRSVYLHNNRLrnTGLPPNTFHGSevITTLSLSSNQLSYL------PPSLPASLERLHLQNNLI 221
Cdd:COG4886  238 NQLTDLPEL--GNLTNLEELDLSNNQL--TDLPPLANLTN--LKTLDLSNNQLTDLklkeleLLLGLNSLLLLLLLLNLL 311

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755526749 222 SKVPRGALSLQTHLRELYLQHNQLTDSGLDATTFSKLSSLEYLDLSHNQLATVPEGLPGTLTILHLGRNCIRHVEAVRL 300
Cdd:COG4886  312 ELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLL 390
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
171-438 7.74e-12

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 67.88  E-value: 7.74e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 171 NNRLRNTGLPPNtfhgsevITTLSLSSNQLSYLPpSLPASLERLHLQNNLISKVPrgalSLQTHLRELYLQHNQLTDSGL 250
Cdd:PRK15387 232 NNLTSLPALPPE-------LRTLEVSGNQLTSLP-VLPPGLLELSIFSNPLTHLP----ALPSGLCKLWIFGNQLTSLPV 299

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 251 DATTFSKLSsleyldLSHNQLATVPeGLPGTLTILHLGRNCIRHVEAVrlhkARGLRYLLLQHNKLGA-SALPKgtlrpl 329
Cdd:PRK15387 300 LPPGLQELS------VSDNQLASLP-ALPSELCKLWAYNNQLTSLPTL----PSGLQELSVSDNQLASlPTLPS------ 362

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 330 rALHTLHLYGNKLERVPpALPRHLQALVMPHNHVAALGardlVSARALAELNLAYNSLASAHVHPSAfrrlraLRSLDLA 409
Cdd:PRK15387 363 -ELYKLWAYNNRLTSLP-ALPSGLKELIVSGNRLTSLP----VLPSELKELMVSGNRLTSLPMLPSG------LLSLSVY 430

                        250       260       270
                 ....*....|....*....|....*....|...
gi 755526749 410 GNQLTRLPEGLP--ASLRSLRLQRNQL--RTLE 438
Cdd:PRK15387 431 RNQLTRLPESLIhlSSETTVNLEGNPLseRTLQ 463
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 162-314 5.09e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 62.50  E-value: 5.09e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 162 PALRSVYLHNNRLRN-TGLPPNTFhgsevITTLSLSSNQLSYLPP--SLPaSLERLHLQNNLISKVprGALSLQTHLREL 238
Cdd:cd21340   24 KNLKVLYLYDNKITKiENLEFLTN-----LTHLYLQNNQIEKIENleNLV-NLKKLYLGGNRISVV--EGLENLTNLEEL 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 239 YLQHNQLtDSG----LDATTFSKLS-SLEYLDLSHNQLATVpEGLPG--TLTILHLGRNCIRHVEAVR--LHKARGLRYL 309
Cdd:cd21340   96 HIENQRL-PPGekltFDPRSLAALSnSLRVLNISGNNIDSL-EPLAPlrNLEQLDASNNQISDLEELLdlLSSWPSLREL 173


                 ....*
gi 755526749 310 LLQHN 314
Cdd:cd21340  174 DLTGN 178
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
193-475 1.88e-10

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 63.64  E-value: 1.88e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 193 LSLSSNQLSYLPPSLPASLERLHLQNNLISKVPrgalSLQTHLRELYLQHNQLTDSGLDATTFSKLSsleyldLSHNQLA 272
Cdd:PRK15387 206 LNVGESGLTTLPDCLPAHITTLVIPDNNLTSLP----ALPPELRTLEVSGNQLTSLPVLPPGLLELS------IFSNPLT 275

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 273 TVPeGLPGTLTILHLGRNCIRHVEAVrlhkARGLRYLLLQHNKLGA-SALPKgtlrplrALHTLHLYGNKLERVpPALPR 351
Cdd:PRK15387 276 HLP-ALPSGLCKLWIFGNQLTSLPVL----PPGLQELSVSDNQLASlPALPS-------ELCKLWAYNNQLTSL-PTLPS 342

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 352 HLQALVMPHNHVAALGA------------RDLVSARA----LAELNLAYNSLASAHVHPSafrrlrALRSLDLAGNQLTR 415
Cdd:PRK15387 343 GLQELSVSDNQLASLPTlpselyklwaynNRLTSLPAlpsgLKELIVSGNRLTSLPVLPS------ELKELMVSGNRLTS 416

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 416 LPEgLPASLRSLRLQRNQLRTLePEQLAGLNKLRELNLAHNrlrvgdigPGTWHELQALK 475
Cdd:PRK15387 417 LPM-LPSGLLSLSVYRNQLTRL-PESLIHLSSETTVNLEGN--------PLSERTLQALR 466
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 161-345 3.13e-10

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 61.60  E-value: 3.13e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 161 KPALRSVYLHNNRL----RNTGLPPNTFHGSEVITTLSLSSNQLSY-LPPSLPA-----SLERLHLQNNLISK-----VP 225
Cdd:cd00116   50 QPSLKELCLSLNETgripRGLQSLLQGLTKGCGLQELDLSDNALGPdGCGVLESllrssSLQELKLNNNGLGDrglrlLA 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 226 RGALSLQTHLRELYLQHNQLTDSGLDAT--TFSKLSSLEYLDLSHNQL-----ATVPEGLPGT--LTILHLGRNCIRHVE 296
Cdd:cd00116  130 KGLKDLPPALEKLVLGRNRLEGASCEALakALRANRDLKELNLANNGIgdagiRALAEGLKANcnLEVLDLNNNGLTDEG 209

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 755526749 297 AVRLHKA----RGLRYLLLQHNKL---GASALPKGTLRPLRALHTLHLYGNKLERV 345
Cdd:cd00116  210 ASALAETlaslKSLEVLNLGDNNLtdaGAAALASALLSPNISLLTLSLSCNDITDD 265
LRR_8 pfam13855
Leucine rich repeat;
210-271 1.22e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.07  E-value: 1.22e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755526749  210 SLERLHLQNNLISKVPRGALSLQTHLRELYLQHNQLTdsGLDATTFSKLSSLEYLDLSHNQL 271
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT--TLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
401-458 1.08e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 51.37  E-value: 1.08e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755526749  401 RALRSLDLAGNQLTRLPEGLPASLRSLR---LQRNQLRTLEPEQLAGLNKLRELNLAHNRL 458
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKvldLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
309-501 1.59e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 57.40  E-value: 1.59e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 309 LLLQHNKLgaSALPKGtlrpLRA-LHTLHLYGNKLERVPPALPRHLQALVMPHNHVAALGARdlvsaralaelnlaynsl 387
Cdd:PRK15370 204 LILDNNEL--KSLPEN----LQGnIKTLYANSNQLTSIPATLPDTIQEMELSINRITELPER------------------ 259

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 388 asahvHPSAfrrlraLRSLDLAGNQLTRLPEGLPASLRSLRLQRNQLRTLePEQLAglNKLRELNLAHNrlrvgdigpgt 467
Cdd:PRK15370 260 -----LPSA------LQSLDLFHNKISCLPENLPEELRYLSVYDNSIRTL-PAHLP--SGITHLNVQSN----------- 314

                        170       180       190
                 ....*....|....*....|....*....|....
gi 755526749 468 whELQALKIKTPPLLKAhLPSPAQQATSQSASCP 501
Cdd:PRK15370 315 --SLTALPETLPPGLKT-LEAGENALTSLPASLP 345
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 67-318 2.60e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 52.36  E-value: 2.60e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749  67 RAARHLSLQNNQLRELPYN------ELSRLSGLRTLDLHSNLITSEGLPD-EAFESLNQLENFYVAHNKLSVAP-QFLPR 138
Cdd:cd00116   51 PSLKELCLSLNETGRIPRGlqsllqGLTKGCGLQELDLSDNALGPDGCGVlESLLRSSSLQELKLNNNGLGDRGlRLLAK 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 139 SLRvaDLaanevveifpltfgeKPALRSVYLHNNRLRNTglppntfhgsevittlslSSNQLSYLPPSLPaSLERLHLQN 218
Cdd:cd00116  131 GLK--DL---------------PPALEKLVLGRNRLEGA------------------SCEALAKALRANR-DLKELNLAN 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 219 NLISkvPRGALSL------QTHLRELYLQHNQLTDSG--LDATTFSKLSSLEYLDLSHNQL-----ATVPEGLPG---TL 282
Cdd:cd00116  175 NGIG--DAGIRALaeglkaNCNLEVLDLNNNGLTDEGasALAETLASLKSLEVLNLGDNNLtdagaAALASALLSpniSL 252

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 755526749 283 TILHLGRNCIRHVEAVRLHKA----RGLRYLLLQHNKLGA 318
Cdd:cd00116  253 LTLSLSCNDITDDGAKDLAEVlaekESLLELDLRGNKFGE 292
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 71-226 1.15e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 49.40  E-value: 1.15e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749  71 HLSLQNNQLRELPYneLSRLSGLRTLDLHSNLITS-EGLpdeafESLNQLENFYVAHNKLSVAPQFL--PRS-------L 140
Cdd:cd21340   50 HLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVvEGL-----ENLTNLEELHIENQRLPPGEKLTfdPRSlaalsnsL 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 141 RVADLAANEVVEIFPLtfgekpalrsVYLHNnrlrntglppntfhgsevITTLSLSSNQLSYLPPSLPA-----SLERLH 215
Cdd:cd21340  123 RVLNISGNNIDSLEPL----------APLRN------------------LEQLDASNNQISDLEELLDLlsswpSLRELD 174

                        170
                 ....*....|.
gi 755526749 216 LQNNLISKVPR 226
Cdd:cd21340  175 LTGNPVCKKPK 185
LRR_8 pfam13855
Leucine rich repeat;
233-316 1.32e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.59  E-value: 1.32e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749  233 THLRELYLQHNQLTDsgLDATTFSKLSSLEYLDLSHNqlatvpeglpgtltilhlgrnCIRHVEAVRLHKARGLRYLLLQ 312
Cdd:pfam13855   1 PNLRSLDLSNNRLTS--LDDGAFKGLSNLKVLDLSNN---------------------LLTTLSPGAFSGLPSLRYLDLS 57


                  ....
gi 755526749  313 HNKL 316
Cdd:pfam13855  58 GNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 162-389 1.02e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 47.86  E-value: 1.02e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 162 PALRSVYLHNNRLRNTGLPPNTFHGSEV--ITTLSLSSNQLS---------YLppSLPASLERLHLQNNLISKvpRGALS 230
Cdd:COG5238  208 TTVTTLWLKRNPIGDEGAEILAEALKGNksLTTLDLSNNQIGdegvialaeAL--KNNTTVETLYLSGNQIGA--EGAIA 283

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 231 L------QTHLRELYLQHNQLTDSGldATTFSKLssleyldLSHNQlatvpeglpgTLTILHLGRNCIRHVEAVRLHKA- 303
Cdd:COG5238  284 LakalqgNTTLTSLDLSVNRIGDEG--AIALAEG-------LQGNK----------TLHTLNLAYNGIGAQGAIALAKAl 344

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 304 ---RGLRYLLLQHNKL---GASALPKgTLRPLRALHTLHLYGNKL-ERVPPALPRHLQalvmpHNHVAALGARD-LVSAR 375
Cdd:COG5238  345 qenTTLHSLDLSDNQIgdeGAIALAK-YLEGNTTLRELNLGKNNIgKQGAEALIDALQ-----TNRLHTLILDGnLIGAE 418

                        250
                 ....*....|....
gi 755526749 376 ALAELNLAYNSLAS 389
Cdd:COG5238  419 AQQRLEQLLERIKS 432
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 234-459 2.65e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 46.19  E-value: 2.65e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 234 HLRELYLQHNQLTDSGLDATtFSKL---SSLEYLDLSHNQLATVPEGLpgtltilhlgrncirHVEAVRLHKARGLRYLL 310
Cdd:cd00116   24 CLQVLRLEGNTLGEEAAKAL-ASALrpqPSLKELCLSLNETGRIPRGL---------------QSLLQGLTKGCGLQELD 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 311 LQHNKLGA--SALPKGTLRPlRALHTLHLYGNKLErvppalPRHLQALvmphnhvaALGARDLVSAraLAELNLAYNSLA 388
Cdd:cd00116   88 LSDNALGPdgCGVLESLLRS-SSLQELKLNNNGLG------DRGLRLL--------AKGLKDLPPA--LEKLVLGRNRLE 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 389 SAHVHP--SAFRRLRALRSLDLAGNQL-----TRLPEGLPAS--LRSLRLQRNQLRTLEPEQLAG----LNKLRELNLAH 455
Cdd:cd00116  151 GASCEAlaKALRANRDLKELNLANNGIgdagiRALAEGLKANcnLEVLDLNNNGLTDEGASALAEtlasLKSLEVLNLGD 230


                 ....
gi 755526749 456 NRLR 459
Cdd:cd00116  231 NNLT 234
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 87-320 3.43e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 46.32  E-value: 3.43e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749  87 LSRLSGLRTLDLHSNLITSEGLPD--EAFESLNQLENFYVAHNKLSVapqflPRSLRVADLAANevveifpltfgeKPAL 164
Cdd:COG5238  232 LKGNKSLTTLDLSNNQIGDEGVIAlaEALKNNTTVETLYLSGNQIGA-----EGAIALAKALQG------------NTTL 294

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 165 RSVYLHNNRLRNTGLPP--NTFHGSEVITTLSLSSNQLSylppslpaslerlhlqnnliskvPRGALSLQTHLRE----- 237
Cdd:COG5238  295 TSLDLSVNRIGDEGAIAlaEGLQGNKTLHTLNLAYNGIG-----------------------AQGAIALAKALQEnttlh 351

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 238 -LYLQHNQLTDSGLDAttfsklssleyldlshnqLATVPEGLPgTLTILHLGRNCIRHVEAVRLHKA---RGLRYLLLQH 313
Cdd:COG5238  352 sLDLSDNQIGDEGAIA------------------LAKYLEGNT-TLRELNLGKNNIGKQGAEALIDAlqtNRLHTLILDG 412


                 ....*..
gi 755526749 314 NKLGASA 320
Cdd:COG5238  413 NLIGAEA 419
LRR_8 pfam13855
Leucine rich repeat;
70-129 5.12e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.97  E-value: 5.12e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749   70 RHLSLQNNQLRELPYNELSRLSGLRTLDLHSNLITSegLPDEAFESLNQLENFYVAHNKL 129
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT--LSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
423-475 5.38e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.97  E-value: 5.38e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 755526749  423 SLRSLRLQRNQLRTLEPEQLAGLNKLRELNLAHNRLRVgdIGPGTWHELQALK 475
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT--LSPGAFSGLPSLR 52
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 248-476 6.88e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.61  E-value: 6.88e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 248 SGLDATTFSKLSSLEYLDLSHNQLATvpeGLPGTLTILhlgrncirhveavrlhkARGLRYLLLQHNKLGASaLPKGTLR 327
Cdd:PLN00113  82 SGKISSAIFRLPYIQTINLSNNQLSG---PIPDDIFTT-----------------SSSLRYLNLSNNNFTGS-IPRGSIP 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 328 PLRA---------------------LHTLHLYGNKLE-RVPPALPR--HLQALVMPHNHVAALGARDLVSARALAELNLA 383
Cdd:PLN00113 141 NLETldlsnnmlsgeipndigsfssLKVLDLGGNVLVgKIPNSLTNltSLEFLTLASNQLVGQIPRELGQMKSLKWIYLG 220

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 384 YNSLaSAHVhPSAFRRLRALRSLDLAGNQLT-RLPEGLP--ASLRSLRLQRNQLRTLEPEQLAGLNKLRELNLAHNRLRv 460
Cdd:PLN00113 221 YNNL-SGEI-PYEIGGLTSLNHLDLVYNNLTgPIPSSLGnlKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLS- 297

                        250
                 ....*....|....*.
gi 755526749 461 GDIgPGTWHELQALKI 476
Cdd:PLN00113 298 GEI-PELVIQLQNLEI 312
LRR_8 pfam13855
Leucine rich repeat;
351-413 8.05e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.59  E-value: 8.05e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755526749  351 RHLQALVMPHNHVAALGARDLVSARALAELNLAYNSLAsaHVHPSAFRRLRALRSLDLAGNQL 413
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT--TLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
191-245 9.90e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.20  E-value: 9.90e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 755526749  191 TTLSLSSNQLSYLPPSL---PASLERLHLQNNLISKVPRGALSLQTHLRELYLQHNQL 245
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAfkgLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
138-200 5.48e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.27  E-value: 5.48e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755526749  138 RSLRVADLAANEVVEIFPLTFGEKPALRSVYLHNNRLrnTGLPPNTFHGSEVITTLSLSSNQL 200
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL--TTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 233-273 2.26e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.07  E-value: 2.26e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 755526749  233 THLRELYLQHNQLTDSGLdattFSKLSSLEYLDLSHNQLAT 273
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPP----LAKLPNLETLDLSGNNKIT 37
PLN03150 PLN03150
hypothetical protein; Provisional
 394-458 2.96e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 40.18  E-value: 2.96e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755526749 394 PSAFRRLRALRSLDLAGNQLT-RLPE--GLPASLRSLRLQRNQLRTLEPEQLAGLNKLRELNLAHNRL 458
Cdd:PLN03150 435 PNDISKLRHLQSINLSGNSIRgNIPPslGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSL 502
LRR_8 pfam13855
Leucine rich repeat;
91-174 4.92e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.58  E-value: 4.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749   91 SGLRTLDLHSNLITSegLPDEAFESLNQLENFYVAHNKLSVapqflprslrvadlaanevveIFPLTFGEKPALRSVYLH 170
Cdd:pfam13855   1 PNLRSLDLSNNRLTS--LDDGAFKGLSNLKVLDLSNNLLTT---------------------LSPGAFSGLPSLRYLDLS 57


                  ....
gi 755526749  171 NNRL 174
Cdd:pfam13855  58 GNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 292-475 6.18e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 38.88  E-value: 6.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 292 IRHVEAVRLHKARGLRYLLLqhNKLGASALPKgTLRPLRALHTLHLYGNKLERVPPALPRHLQAlvmphnhvaalgardL 371
Cdd:cd00116   16 TELLPKLLCLQVLRLEGNTL--GEEAAKALAS-ALRPQPSLKELCLSLNETGRIPRGLQSLLQG---------------L 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526749 372 VSARALAELNLAYNSLASAHVHP-SAFRRLRALRSLDLAGNQLTRLPEGL--------PASLRSLRLQRNQLRTLEPEQL 442
Cdd:cd00116   78 TKGCGLQELDLSDNALGPDGCGVlESLLRSSSLQELKLNNNGLGDRGLRLlakglkdlPPALEKLVLGRNRLEGASCEAL 157

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 755526749 443 AGL----NKLRELNLAHNRLRvgdiGPGTWHELQALK 475
Cdd:cd00116  158 AKAlranRDLKELNLANNGIG----DAGIRALAEGLK 190
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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