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Conserved domains on  [gi|755526964|ref|XP_011246729|]
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carboxylesterase 3A isoform X1 [Mus musculus]

Protein Classification

carboxylesterase/lipase family protein( domain architecture ID 10444481)

carboxylesterase/lipase family protein similar to carboxylesterase, which catalyzes the hydrolysis of a carboxylic ester to form an alcohol and a carboxylate, and lipase, which hydrolyzes triglycerides into diglycerides and subsequently into monoglycerides and free fatty acids

CATH:  3.40.50.1820
EC:  3.1.1.-
PubMed:  8453375|3163407|8280778|9704093|11099800
SCOP:  3000102

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COesterase pfam00135
Carboxylesterase family;
36-507 0e+00

Carboxylesterase family;


:

Pssm-ID: 395084 [Multi-domain]  Cd Length: 513  Bit Score: 568.48  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526964   36 QPEVDTPLGRVRGRQVGVKDTDrMVNVFLGIPFAQAPLGPLRFSAPLPPQPWEGVRDASINPPMCLQDVERMSNSRFTLn 115
Cdd:pfam00135   2 SPVVTTSLGRVRGKRLKVDGGK-PVYAFLGIPYAEPPVGELRFQPPEPPEPWTGVRDATKFGPRCPQNGDLTSPGSSGL- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526964  116 ekmkifPISEDCLTLNIYSPTEITAGD-KRPVMVWIHGGSLLVGSSTSHDGSALAAYGDVVVVTVQYRLGIFGFLSTGDK 194
Cdd:pfam00135  80 ------EGSEDCLYLNVYTPKELKENKnKLPVMVWIHGGGFMFGSGSLYDGSYLAAEGDVIVVTINYRLGPLGFLSTGDD 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526964  195 HMPGNRGFLDVVAALRWVQGNIAPFGGDPNCVTIFGNSAGGIIVSSLLLSPMSAGLFHRAISQSGVVISKILEDLNAWSE 274
Cdd:pfam00135 154 EAPGNYGLLDQVLALRWVQENIASFGGDPNRVTLFGESAGAASVSLLLLSPLSKGLFHRAILMSGSALSPWAIQSNARQR 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526964  275 AQNFANSVACGSASPAELVQCLLQKEGKDLITKKNVNISY----------TVNDSFFPQRPQKLLANKQFPTVPYLLGVT 344
Cdd:pfam00135 234 AKELAKLVGCPTSDSAELVECLRSKPAEELLDAQLKLLVYgsvpfvpfgpVVDGDFLPEHPEELLKSGNFPKVPLLIGVT 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526964  345 NHEFGWLLLKFWNILDKMEHLSQEDLLENSRPLLAHM--QLPPEIMPTVIDEYLDNGS--DESATRYALQELLGDITLVI 420
Cdd:pfam00135 314 KDEGLLFAAYILDNVDILKALEEKLLRSLLIDLLYLLlvDLPEEISAALREEYLDWGDrdDPETSRRALVELLTDYLFNC 393

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526964  421 PTLIFSKYLQDAGCPVFLYEFQHTPSSFakFKPAWVKADHSSENAFVFGGPFLTDEssllafpEATEEEKQLSLTMMAQW 500
Cdd:pfam00135 394 PVIRFADLHASRGTPVYMYSFDYRGSSL--RYPKWVGVDHGDELPYVFGTPFVGAL-------LFTEEDEKLSRKMMTYW 464


                  ....*..
gi 755526964  501 SQFARTG 507
Cdd:pfam00135 465 TNFAKTG 471
 
Name Accession Description Interval E-value
COesterase pfam00135
Carboxylesterase family;
36-507 0e+00

Carboxylesterase family;


Pssm-ID: 395084 [Multi-domain]  Cd Length: 513  Bit Score: 568.48  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526964   36 QPEVDTPLGRVRGRQVGVKDTDrMVNVFLGIPFAQAPLGPLRFSAPLPPQPWEGVRDASINPPMCLQDVERMSNSRFTLn 115
Cdd:pfam00135   2 SPVVTTSLGRVRGKRLKVDGGK-PVYAFLGIPYAEPPVGELRFQPPEPPEPWTGVRDATKFGPRCPQNGDLTSPGSSGL- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526964  116 ekmkifPISEDCLTLNIYSPTEITAGD-KRPVMVWIHGGSLLVGSSTSHDGSALAAYGDVVVVTVQYRLGIFGFLSTGDK 194
Cdd:pfam00135  80 ------EGSEDCLYLNVYTPKELKENKnKLPVMVWIHGGGFMFGSGSLYDGSYLAAEGDVIVVTINYRLGPLGFLSTGDD 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526964  195 HMPGNRGFLDVVAALRWVQGNIAPFGGDPNCVTIFGNSAGGIIVSSLLLSPMSAGLFHRAISQSGVVISKILEDLNAWSE 274
Cdd:pfam00135 154 EAPGNYGLLDQVLALRWVQENIASFGGDPNRVTLFGESAGAASVSLLLLSPLSKGLFHRAILMSGSALSPWAIQSNARQR 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526964  275 AQNFANSVACGSASPAELVQCLLQKEGKDLITKKNVNISY----------TVNDSFFPQRPQKLLANKQFPTVPYLLGVT 344
Cdd:pfam00135 234 AKELAKLVGCPTSDSAELVECLRSKPAEELLDAQLKLLVYgsvpfvpfgpVVDGDFLPEHPEELLKSGNFPKVPLLIGVT 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526964  345 NHEFGWLLLKFWNILDKMEHLSQEDLLENSRPLLAHM--QLPPEIMPTVIDEYLDNGS--DESATRYALQELLGDITLVI 420
Cdd:pfam00135 314 KDEGLLFAAYILDNVDILKALEEKLLRSLLIDLLYLLlvDLPEEISAALREEYLDWGDrdDPETSRRALVELLTDYLFNC 393

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526964  421 PTLIFSKYLQDAGCPVFLYEFQHTPSSFakFKPAWVKADHSSENAFVFGGPFLTDEssllafpEATEEEKQLSLTMMAQW 500
Cdd:pfam00135 394 PVIRFADLHASRGTPVYMYSFDYRGSSL--RYPKWVGVDHGDELPYVFGTPFVGAL-------LFTEEDEKLSRKMMTYW 464


                  ....*..
gi 755526964  501 SQFARTG 507
Cdd:pfam00135 465 TNFAKTG 471
Esterase_lipase cd00312
Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on ...
 38-507 4.43e-152

Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These catalytic residues are responsible for the nucleophilic attack on the carbonyl carbon atom of the ester bond. In contrast with other alpha/beta hydrolase fold family members, p-nitrobenzyl esterase and acetylcholine esterase have a Glu instead of Asp at the active site carboxylate.


Pssm-ID: 238191 [Multi-domain]  Cd Length: 493  Bit Score: 443.31  E-value: 4.43e-152
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526964  38 EVDTPLGRVRGRQVGVkdtdrmVNVFLGIPFAQAPLGPLRFSAPLPPQPWEGVRDASINPPMCLQDVErmsNSRFTLNEK 117
Cdd:cd00312    1 LVVTPNGKVRGVDEGG------VYSFLGIPYAEPPVGDLRFKEPQPYEPWSDVLDATSYPPSCMQWDQ---LGGGLWNAK 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526964 118 MkifPISEDCLTLNIYSPTEITAGDKRPVMVWIHGGSLLVGSSTSHDGSALAAYGD-VVVVTVQYRLGIFGFLSTGDKHM 196
Cdd:cd00312   72 L---PGSEDCLYLNVYTPKNTKPGNSLPVMVWIHGGGFMFGSGSLYPGDGLAREGDnVIVVSINYRLGVLGFLSTGDIEL 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526964 197 PGNRGFLDVVAALRWVQGNIAPFGGDPNCVTIFGNSAGGIIVSSLLLSPMSAGLFHRAISQSGVVIS--KILEDLNAWse 274
Cdd:cd00312  149 PGNYGLKDQRLALKWVQDNIAAFGGDPDSVTIFGESAGGASVSLLLLSPDSKGLFHRAISQSGSALSpwAIQENARGR-- 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526964 275 AQNFANSVACGSASPAELVQCLLQKEGKDLITKKNVNISY----------TVNDSFFPQRPQKLLANKQFPTVPYLLGVT 344
Cdd:cd00312  227 AKRLARLLGCNDTSSAELLDCLRSKSAEELLDATRKLLLFsyspflpfgpVVDGDFIPDDPEELIKEGKFAKVPLIIGVT 306

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526964 345 NHEFGWLLLKFWNILDKMEHLSQEDLLENSRPLLAHmqLPPEIMPTVIDEYLDNGSDESATRYALQELLGDITLVIPTLI 424
Cdd:cd00312  307 KDEGGYFAAMLLNFDAKLIIETNDRWLELLPYLLFY--ADDALADKVLEKYPGDVDDSVESRKNLSDMLTDLLFKCPARY 384

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526964 425 F-SKYLQDAGCPVFLYEFQHTPSSFAKFKPAWVKADHSSENAFVFGGPFLTdessllafPEATEEEKQLSLTMMAQWSQF 503
Cdd:cd00312  385 FlAQHRKAGGSPVYAYVFDHRSSLSVGRWPPWLGTVHGDEIFFVFGNPLLK--------EGLREEEEKLSRTMMKYWANF 456


                 ....
gi 755526964 504 ARTG 507
Cdd:cd00312  457 AKTG 460
PnbA COG2272
Carboxylesterase type B [Lipid transport and metabolism];
35-507 1.60e-132

Carboxylesterase type B [Lipid transport and metabolism];


Pssm-ID: 441873  Cd Length: 500  Bit Score: 393.48  E-value: 1.60e-132
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526964  35 TQPEVDTPLGRVRGRqvgvkdTDRMVNVFLGIPFAQAPLGPLRFSAPLPPQPWEGVRDASINPPMCLQDVERMSNSRFTl 114
Cdd:COG2272   11 AAPVVRTEAGRVRGV------VEGGVRVFLGIPYAAPPVGELRWRAPQPVEPWTGVRDATEFGPACPQPPRPGDPGGPA- 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526964 115 nekmkifPISEDCLTLNIYSPtEITAGDKRPVMVWIHGGSLLVGSSTS--HDGSALAAYGdVVVVTVQYRLGIFGF---- 188
Cdd:COG2272   84 -------PGSEDCLYLNVWTP-ALAAGAKLPVMVWIHGGGFVSGSGSEplYDGAALARRG-VVVVTINYRLGALGFlalp 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526964 189 -LSTGDKHMPGNRGFLDVVAALRWVQGNIAPFGGDPNCVTIFGNSAGGIIVSSLLLSPMSAGLFHRAISQSGVVISKI-L 266
Cdd:COG2272  155 aLSGESYGASGNYGLLDQIAALRWVRDNIAAFGGDPDNVTIFGESAGAASVAALLASPLAKGLFHRAIAQSGAGLSVLtL 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526964 267 EDLNAWseAQNFANSVACGSASPAEL----VQCLLQKEGKdLITKKNVNISY--TVNDSFFPQRPQKLLANKQFPTVPYL 340
Cdd:COG2272  235 AEAEAV--GAAFAAALGVAPATLAALralpAEELLAAQAA-LAAEGPGGLPFgpVVDGDVLPEDPLEAFAAGRAADVPLL 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526964 341 LGVTNHEfGWLLLKFWNILDKMEHLSQEDLLEnsrpllahmQLPPEIMPTVIDEYLDNGSDESATRyalqeLLGDITLVI 420
Cdd:COG2272  312 IGTNRDE-GRLFAALLGDLGPLTAADYRAALR---------RRFGDDADEVLAAYPAASPAEALAA-----LATDRVFRC 376

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526964 421 PTLIFSKYLQDAGCPVFLYEFQHTPSSFAKFKP-AWvkadHSSENAFVFGgpfLTDESSLLAFpeaTEEEKQLSLTMMAQ 499
Cdd:COG2272  377 PARRLAEAHAAAGAPVYLYRFDWRSPPLRGFGLgAF----HGAELPFVFG---NLDAPALTGL---TPADRALSDQMQAY 446


                 ....*...
gi 755526964 500 WSQFARTG 507
Cdd:COG2272  447 WVNFARTG 454
PRK10162 PRK10162
acetyl esterase;
128-234 3.57e-03

acetyl esterase;


Pssm-ID: 236660 [Multi-domain]  Cd Length: 318  Bit Score: 39.70  E-value: 3.57e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526964 128 LTLNIYSPTEitagDKRPVMVWIHGGSLLVGSSTSHDGSA--LAAYGDVVVVTVQYRLGifgflstgdkhmPGNR---GF 202
Cdd:PRK10162  69 VETRLYYPQP----DSQATLFYLHGGGFILGNLDTHDRIMrlLASYSGCTVIGIDYTLS------------PEARfpqAI 132

                         90       100       110
                 ....*....|....*....|....*....|..
gi 755526964 203 LDVVAALRWVQGNIAPFGGDPNCVTIFGNSAG 234
Cdd:PRK10162 133 EEIVAVCCYFHQHAEDYGINMSRIGFAGDSAG 164
 
Name Accession Description Interval E-value
COesterase pfam00135
Carboxylesterase family;
36-507 0e+00

Carboxylesterase family;


Pssm-ID: 395084 [Multi-domain]  Cd Length: 513  Bit Score: 568.48  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526964   36 QPEVDTPLGRVRGRQVGVKDTDrMVNVFLGIPFAQAPLGPLRFSAPLPPQPWEGVRDASINPPMCLQDVERMSNSRFTLn 115
Cdd:pfam00135   2 SPVVTTSLGRVRGKRLKVDGGK-PVYAFLGIPYAEPPVGELRFQPPEPPEPWTGVRDATKFGPRCPQNGDLTSPGSSGL- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526964  116 ekmkifPISEDCLTLNIYSPTEITAGD-KRPVMVWIHGGSLLVGSSTSHDGSALAAYGDVVVVTVQYRLGIFGFLSTGDK 194
Cdd:pfam00135  80 ------EGSEDCLYLNVYTPKELKENKnKLPVMVWIHGGGFMFGSGSLYDGSYLAAEGDVIVVTINYRLGPLGFLSTGDD 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526964  195 HMPGNRGFLDVVAALRWVQGNIAPFGGDPNCVTIFGNSAGGIIVSSLLLSPMSAGLFHRAISQSGVVISKILEDLNAWSE 274
Cdd:pfam00135 154 EAPGNYGLLDQVLALRWVQENIASFGGDPNRVTLFGESAGAASVSLLLLSPLSKGLFHRAILMSGSALSPWAIQSNARQR 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526964  275 AQNFANSVACGSASPAELVQCLLQKEGKDLITKKNVNISY----------TVNDSFFPQRPQKLLANKQFPTVPYLLGVT 344
Cdd:pfam00135 234 AKELAKLVGCPTSDSAELVECLRSKPAEELLDAQLKLLVYgsvpfvpfgpVVDGDFLPEHPEELLKSGNFPKVPLLIGVT 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526964  345 NHEFGWLLLKFWNILDKMEHLSQEDLLENSRPLLAHM--QLPPEIMPTVIDEYLDNGS--DESATRYALQELLGDITLVI 420
Cdd:pfam00135 314 KDEGLLFAAYILDNVDILKALEEKLLRSLLIDLLYLLlvDLPEEISAALREEYLDWGDrdDPETSRRALVELLTDYLFNC 393

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526964  421 PTLIFSKYLQDAGCPVFLYEFQHTPSSFakFKPAWVKADHSSENAFVFGGPFLTDEssllafpEATEEEKQLSLTMMAQW 500
Cdd:pfam00135 394 PVIRFADLHASRGTPVYMYSFDYRGSSL--RYPKWVGVDHGDELPYVFGTPFVGAL-------LFTEEDEKLSRKMMTYW 464


                  ....*..
gi 755526964  501 SQFARTG 507
Cdd:pfam00135 465 TNFAKTG 471
Esterase_lipase cd00312
Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on ...
 38-507 4.43e-152

Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These catalytic residues are responsible for the nucleophilic attack on the carbonyl carbon atom of the ester bond. In contrast with other alpha/beta hydrolase fold family members, p-nitrobenzyl esterase and acetylcholine esterase have a Glu instead of Asp at the active site carboxylate.


Pssm-ID: 238191 [Multi-domain]  Cd Length: 493  Bit Score: 443.31  E-value: 4.43e-152
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526964  38 EVDTPLGRVRGRQVGVkdtdrmVNVFLGIPFAQAPLGPLRFSAPLPPQPWEGVRDASINPPMCLQDVErmsNSRFTLNEK 117
Cdd:cd00312    1 LVVTPNGKVRGVDEGG------VYSFLGIPYAEPPVGDLRFKEPQPYEPWSDVLDATSYPPSCMQWDQ---LGGGLWNAK 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526964 118 MkifPISEDCLTLNIYSPTEITAGDKRPVMVWIHGGSLLVGSSTSHDGSALAAYGD-VVVVTVQYRLGIFGFLSTGDKHM 196
Cdd:cd00312   72 L---PGSEDCLYLNVYTPKNTKPGNSLPVMVWIHGGGFMFGSGSLYPGDGLAREGDnVIVVSINYRLGVLGFLSTGDIEL 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526964 197 PGNRGFLDVVAALRWVQGNIAPFGGDPNCVTIFGNSAGGIIVSSLLLSPMSAGLFHRAISQSGVVIS--KILEDLNAWse 274
Cdd:cd00312  149 PGNYGLKDQRLALKWVQDNIAAFGGDPDSVTIFGESAGGASVSLLLLSPDSKGLFHRAISQSGSALSpwAIQENARGR-- 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526964 275 AQNFANSVACGSASPAELVQCLLQKEGKDLITKKNVNISY----------TVNDSFFPQRPQKLLANKQFPTVPYLLGVT 344
Cdd:cd00312  227 AKRLARLLGCNDTSSAELLDCLRSKSAEELLDATRKLLLFsyspflpfgpVVDGDFIPDDPEELIKEGKFAKVPLIIGVT 306

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526964 345 NHEFGWLLLKFWNILDKMEHLSQEDLLENSRPLLAHmqLPPEIMPTVIDEYLDNGSDESATRYALQELLGDITLVIPTLI 424
Cdd:cd00312  307 KDEGGYFAAMLLNFDAKLIIETNDRWLELLPYLLFY--ADDALADKVLEKYPGDVDDSVESRKNLSDMLTDLLFKCPARY 384

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526964 425 F-SKYLQDAGCPVFLYEFQHTPSSFAKFKPAWVKADHSSENAFVFGGPFLTdessllafPEATEEEKQLSLTMMAQWSQF 503
Cdd:cd00312  385 FlAQHRKAGGSPVYAYVFDHRSSLSVGRWPPWLGTVHGDEIFFVFGNPLLK--------EGLREEEEKLSRTMMKYWANF 456


                 ....
gi 755526964 504 ARTG 507
Cdd:cd00312  457 AKTG 460
PnbA COG2272
Carboxylesterase type B [Lipid transport and metabolism];
35-507 1.60e-132

Carboxylesterase type B [Lipid transport and metabolism];


Pssm-ID: 441873  Cd Length: 500  Bit Score: 393.48  E-value: 1.60e-132
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526964  35 TQPEVDTPLGRVRGRqvgvkdTDRMVNVFLGIPFAQAPLGPLRFSAPLPPQPWEGVRDASINPPMCLQDVERMSNSRFTl 114
Cdd:COG2272   11 AAPVVRTEAGRVRGV------VEGGVRVFLGIPYAAPPVGELRWRAPQPVEPWTGVRDATEFGPACPQPPRPGDPGGPA- 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526964 115 nekmkifPISEDCLTLNIYSPtEITAGDKRPVMVWIHGGSLLVGSSTS--HDGSALAAYGdVVVVTVQYRLGIFGF---- 188
Cdd:COG2272   84 -------PGSEDCLYLNVWTP-ALAAGAKLPVMVWIHGGGFVSGSGSEplYDGAALARRG-VVVVTINYRLGALGFlalp 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526964 189 -LSTGDKHMPGNRGFLDVVAALRWVQGNIAPFGGDPNCVTIFGNSAGGIIVSSLLLSPMSAGLFHRAISQSGVVISKI-L 266
Cdd:COG2272  155 aLSGESYGASGNYGLLDQIAALRWVRDNIAAFGGDPDNVTIFGESAGAASVAALLASPLAKGLFHRAIAQSGAGLSVLtL 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526964 267 EDLNAWseAQNFANSVACGSASPAEL----VQCLLQKEGKdLITKKNVNISY--TVNDSFFPQRPQKLLANKQFPTVPYL 340
Cdd:COG2272  235 AEAEAV--GAAFAAALGVAPATLAALralpAEELLAAQAA-LAAEGPGGLPFgpVVDGDVLPEDPLEAFAAGRAADVPLL 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526964 341 LGVTNHEfGWLLLKFWNILDKMEHLSQEDLLEnsrpllahmQLPPEIMPTVIDEYLDNGSDESATRyalqeLLGDITLVI 420
Cdd:COG2272  312 IGTNRDE-GRLFAALLGDLGPLTAADYRAALR---------RRFGDDADEVLAAYPAASPAEALAA-----LATDRVFRC 376

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526964 421 PTLIFSKYLQDAGCPVFLYEFQHTPSSFAKFKP-AWvkadHSSENAFVFGgpfLTDESSLLAFpeaTEEEKQLSLTMMAQ 499
Cdd:COG2272  377 PARRLAEAHAAAGAPVYLYRFDWRSPPLRGFGLgAF----HGAELPFVFG---NLDAPALTGL---TPADRALSDQMQAY 446


                 ....*...
gi 755526964 500 WSQFARTG 507
Cdd:COG2272  447 WVNFARTG 454
Aes COG0657
Acetyl esterase/lipase [Lipid transport and metabolism];
132-243 1.38e-21

Acetyl esterase/lipase [Lipid transport and metabolism];


Pssm-ID: 440422 [Multi-domain]  Cd Length: 207  Bit Score: 92.63  E-value: 1.38e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526964 132 IYSPTEitAGDKRPVMVWIHGGSLLVGSSTSHDG--SALAAYGDVVVVTVQYRLGifgflstgdkhmPGNR---GFLDVV 206
Cdd:COG0657    3 VYRPAG--AKGPLPVVVYFHGGGWVSGSKDTHDPlaRRLAARAGAAVVSVDYRLA------------PEHPfpaALEDAY 68

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 755526964 207 AALRWVQGNIAPFGGDPNCVTIFGNSAGGIIVSSLLL 243
Cdd:COG0657   69 AALRWLRANAAELGIDPDRIAVAGDSAGGHLAAALAL 105
Abhydrolase_3 pfam07859
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 147-276 1.91e-17

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 400284 [Multi-domain]  Cd Length: 208  Bit Score: 80.72  E-value: 1.91e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526964  147 MVWIHGGSLLVGSSTSHDG--SALAAYGDVVVVTVQYRLGifgflstgdkhmPGNR---GFLDVVAALRWVQGNIAPFGG 221
Cdd:pfam07859   1 LVYFHGGGFVLGSADTHDRlcRRLAAEAGAVVVSVDYRLA------------PEHPfpaAYDDAYAALRWLAEQAAELGA 68

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526964  222 DPNCVTIFGNSAGGIIvsslllspmSAGLFHRAISQSGVVISKIL-----EDLNAWSEAQ 276
Cdd:pfam07859  69 DPSRIAVAGDSAGGNL---------AAAVALRARDEGLPKPAGQVliypgTDLRTESPSY 119
BD-FAE pfam20434
BD-FAE; This family represents a novel bifunctional feruloyl and acetyl xylan esterase (BD-FAE, ...
 130-235 8.23e-11

BD-FAE; This family represents a novel bifunctional feruloyl and acetyl xylan esterase (BD-FAE, previously known as bifunctional carbohydrate esterase (CE)), which is active on complex natural xylans and was identified as the basis of a monophyletic clade gathering all homologs identified in PULs (polysaccharide utilization loci) predicted to act on xylan. It adopts an alpha-beta-hydrolase fold with the catalytic triad Ser-Asp-His. This new family of proteins is a new candidate for biomass processing due to its capacity to remove ferulic acid and acetic acid from natural corn and birchwood xylan substrates.


Pssm-ID: 466583 [Multi-domain]  Cd Length: 215  Bit Score: 61.81  E-value: 8.23e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526964  130 LNIYSPTeiTAGDKRPVMVWIHGGSLLVGSSTSHDG------SALAAYGdVVVVTVQYRLgifgflsTGDKHMPG--Nrg 201
Cdd:pfam20434   1 LDIYLPK--NAKGPYPVVIWIHGGGWNSGDKEADMGfmtntvKALLKAG-YAVASINYRL-------STDAKFPAqiQ-- 68

                          90       100       110
                  ....*....|....*....|....*....|....
gi 755526964  202 flDVVAALRWVQGNIAPFGGDPNCVTIFGNSAGG 235
Cdd:pfam20434  69 --DVKAAIRFLRANAAKYGIDTNKIALMGFSAGG 100
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
124-260 4.42e-08

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 53.87  E-value: 4.42e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526964 124 SEDCLTLN--IYSPTEitaGDKRPVMVWIHGGSLLVGSSTSHDGSALAAYGdVVVVTVQYRlgifGF-LSTGDkhmPGNR 200
Cdd:COG1506    4 SADGTTLPgwLYLPAD---GKKYPVVVYVHGGPGSRDDSFLPLAQALASRG-YAVLAPDYR----GYgESAGD---WGGD 72

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755526964 201 GFLDVVAALRWV--QGNIapfggDPNCVTIFGNSAGGIIVSSLLLspMSAGLFHRAISQSGV 260
Cdd:COG1506   73 EVDDVLAAIDYLaaRPYV-----DPDRIGIYGHSYGGYMALLAAA--RHPDRFKAAVALAGV 127
Fes COG2382
Enterochelin esterase or related enzyme [Inorganic ion transport and metabolism];
129-259 2.75e-03

Enterochelin esterase or related enzyme [Inorganic ion transport and metabolism];


Pssm-ID: 441948 [Multi-domain]  Cd Length: 314  Bit Score: 39.84  E-value: 2.75e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526964 129 TLNIYSPTEITAGDKR-PVMVWIHGGSllvGSSTS--HDGSA------LAAYGDV---VVVTVQYRLGifgflSTGDKHM 196
Cdd:COG2382   96 RVWVYLPPGYDNPGKKyPVLYLLDGGG---GDEQDwfDQGRLptildnLIAAGKIppmIVVMPDGGDG-----GDRGTEG 167

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755526964 197 PGNRGFLDVVAA--LRWVQGNiAPFGGDPNCVTIFGNSAGGIivSSLLLSPMSAGLFHRAISQSG 259
Cdd:COG2382  168 PGNDAFERFLAEelIPFVEKN-YRVSADPEHRAIAGLSMGGL--AALYAALRHPDLFGYVGSFSG 229
Esterase pfam00756
Putative esterase; This family contains Esterase D. However it is not clear if all members of ...
 113-261 2.84e-03

Putative esterase; This family contains Esterase D. However it is not clear if all members of the family have the same function. This family is related to the pfam00135 family.


Pssm-ID: 395613 [Multi-domain]  Cd Length: 246  Bit Score: 39.37  E-value: 2.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526964  113 TLNEKMKIfpisedcltlNIYSPTEITAGDKRPVMVWIHGGSL--------LVGSSTSHDGSALAA-----YGDVVVVTV 179
Cdd:pfam00756   3 SLGREMKV----------QVYLPEDYPPGRKYPVLYLLDGTGWfqngpakeGLDRLAASGEIPPVIivgspRGGEVSFYS 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526964  180 QYRLGIFGflstgdKHMPGNRGFLDVVAA--LRWVQGNiapFGGDPNCVTIFGNSAGGiiVSSLLLSPMSAGLFHRAISQ 257
Cdd:pfam00756  73 DWDRGLNA------TEGPGAYAYETFLTQelPPLLDAN---FPTAPDGRALAGQSMGG--LGALYLALKYPDLFGSVSSF 141


                  ....
gi 755526964  258 SGVV 261
Cdd:pfam00756 142 SPIL 145
PRK10162 PRK10162
acetyl esterase;
128-234 3.57e-03

acetyl esterase;


Pssm-ID: 236660 [Multi-domain]  Cd Length: 318  Bit Score: 39.70  E-value: 3.57e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526964 128 LTLNIYSPTEitagDKRPVMVWIHGGSLLVGSSTSHDGSA--LAAYGDVVVVTVQYRLGifgflstgdkhmPGNR---GF 202
Cdd:PRK10162  69 VETRLYYPQP----DSQATLFYLHGGGFILGNLDTHDRIMrlLASYSGCTVIGIDYTLS------------PEARfpqAI 132

                         90       100       110
                 ....*....|....*....|....*....|..
gi 755526964 203 LDVVAALRWVQGNIAPFGGDPNCVTIFGNSAG 234
Cdd:PRK10162 133 EEIVAVCCYFHQHAEDYGINMSRIGFAGDSAG 164
Peptidase_S9 pfam00326
Prolyl oligopeptidase family;
160-261 3.64e-03

Prolyl oligopeptidase family;


Pssm-ID: 459761 [Multi-domain]  Cd Length: 213  Bit Score: 38.75  E-value: 3.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526964  160 STSHDGSALAAYGdVVVVTVQYR-LGIFG--FLSTGDKHMpGNRGFLDVVAALRWVqgnIAPFGGDPNCVTIFGNSAGGI 236
Cdd:pfam00326   2 SFSWNAQLLADRG-YVVAIANGRgSGGYGeaFHDAGKGDL-GQNEFDDFIAAAEYL---IEQGYTDPDRLAIWGGSYGGY 76

                          90       100
                  ....*....|....*....|....*
gi 755526964  237 IVSSLLLspMSAGLFHRAISQSGVV 261
Cdd:pfam00326  77 LTGAALN--QRPDLFKAAVAHVPVV 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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