|
Name |
Accession |
Description |
Interval |
E-value |
| Atypical_Card |
pfam18461 |
Atypical caspase recruitment domain; The N-terminal effector domain found in NLRC5. It adopts ... |
1-94 |
5.61e-48 |
|
Atypical caspase recruitment domain; The N-terminal effector domain found in NLRC5. It adopts a six alpha-helix bundle with a general death fold. Structure and sequence analysis of the NLRC5-N indicate that it possesses a fold similar to the one of the death-fold domains; however, it displays significant differences in the number of core alpha-helices and their relative orientation. Hence, it is suggested that NLRC5 belongs to the caspase recruitment domain (CARD) subfamily as an atypical CARD. :
Pssm-ID: 436519 Cd Length: 95 Bit Score: 166.36 E-value: 5.61e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 1 MDAESIRLNNENLWAWLVRLLSKNPEWLSAKLRSFLPTMDLDCSYEPSNP-EVIHRQLNRLFAQGMATWKSFINDLCFEL 79
Cdd:pfam18461 1 MDPESLQLGTENLWPWLVRLLSKNPEWLSAKVKFFLPNMDLGSSNEAPDPtQKVILQLDRLEAQGLATWQSFIHCVCMEL 80
|
90
....*....|....*
gi 755526967 80 DVPLDMEIPLVSIWG 94
Cdd:pfam18461 81 EVPLDLEVPLLSTWG 95
|
|
| PPP1R42 super family |
cl42388 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
1520-1782 |
4.48e-31 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation. The actual alignment was detected with superfamily member cd00116:
Pssm-ID: 455733 [Multi-domain] Cd Length: 319 Bit Score: 125.55 E-value: 4.48e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 1520 HHLEELDFSNNSLREEDTELLMGALQGTCRLKKLHLSFLPLGAS--SLALLIQGLSRMTLLQDLCLSHNQIGDVGTQCLA 1597
Cdd:cd00116 23 LCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGRIprGLQSLLQGLTKGCGLQELDLSDNALGPDGCGVLE 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 1598 AILpKLPELRKFDLSHNQIGDVGTQCLAAILPKLPE-LRKFNLSHNQIGHVGTQCLAAILPKLPELRKFDLSRNQIGDVG 1676
Cdd:cd00116 103 SLL-RSSSLQELKLNNNGLGDRGLRLLAKGLKDLPPaLEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAG 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 1677 TQCLAAILPKLPELRKFDLSGNRIGPAGGVQLVKSLTHFEHLEEIKLGNNALGEPTALELAQRLP---PQLRVLCLPSSH 1753
Cdd:cd00116 182 IRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALASALLspnISLLTLSLSCND 261
|
250 260
....*....|....*....|....*....
gi 755526967 1754 LGPEGALGLAQALEQCPHIEEVSLAENNL 1782
Cdd:cd00116 262 ITDDGAKDLAEVLAEKESLLELDLRGNKF 290
|
|
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
223-385 |
9.74e-31 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931. :
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 119.72 E-value: 9.74e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 223 RVTVLLGKAGMGKTTLAYRLRWRWAQGQLDR-FQALFLFEFRQLNMITQLPTLPQLLFDLYLMPESEPDAVFQYLKENAQ 301
Cdd:pfam05729 1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQgFDFVFFLPCRELSRSGNARSLADLLFSQWPEPAAPVSEVWAVILELPE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 302 EVLLIFDGLDEALHADSVgTDNAGSALTLFSELCHGNLLPGCWVMTTSRPG---KLPSCVPtEAATVHMWGFDGLRVEKY 378
Cdd:pfam05729 81 RLLLILDGLDELVSDLGQ-LDGPCPVLTLLSSLLRKKLLPGASLLLTVRPDalrDLRRGLE-EPRYLEVRGFSESDRKQY 158
|
....*..
gi 755526967 379 VTCFFSD 385
Cdd:pfam05729 159 VRKYFSD 165
|
|
| PPP1R42 super family |
cl42388 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
735-1045 |
1.54e-13 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation. The actual alignment was detected with superfamily member cd00116:
Pssm-ID: 455733 [Multi-domain] Cd Length: 319 Bit Score: 73.54 E-value: 1.54e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 735 SHLIQTLPLCSQLEEVSLHDNQLKDPEVLSLVELLPSLPKLQKLDLSRNSFSRS--ILLSLVKVAITCPTVRKLQVRELD 812
Cdd:cd00116 13 ERATELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGRIprGLQSLLQGLTKGCGLQELDLSDNA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 813 LIFYLSPVTETATQ----------QSGASDVQGK---DSLKEGQSRSLQLRLQKCQLRIRDAEALVELFQKSPQLEEVNL 879
Cdd:cd00116 93 LGPDGCGVLESLLRssslqelklnNNGLGDRGLRllaKGLKDLPPALEKLVLGRNRLEGASCEALAKALRANRDLKELNL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 880 SGNHLEDDGCRLVAEAASQLHIAQKLDLSDNGLSQTGVTYVLKAMSTCGTLEDLHIsllnntvvltfaqepreqeGSCKG 959
Cdd:cd00116 173 ANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNL-------------------GDNNL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 960 RAPLISFVSPVTSELSQRSRRIRLTHCGFLAKHTETLCEALRASCQthnLDHLDLSDNSLGGKGVILLTELLPGLGP-LK 1038
Cdd:cd00116 234 TDAGAAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKES---LLELDLRGNKFGEEGAQLLAESLLEPGNeLE 310
|
....*..
gi 755526967 1039 SLNLSRN 1045
Cdd:cd00116 311 SLWVKDD 317
|
|
| PPP1R42 super family |
cl42388 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
611-895 |
3.05e-12 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation. The actual alignment was detected with superfamily member cd00116:
Pssm-ID: 455733 [Multi-domain] Cd Length: 319 Bit Score: 69.69 E-value: 3.05e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 611 TGPKMIELYHCVAETQDLELARFtaQSLPSRLSFHNFPLTHADLaalanilehrdDPIHLDFDGCPLePHCPEAL--VGC 688
Cdd:cd00116 79 KGCGLQELDLSDNALGPDGCGVL--ESLLRSSSLQELKLNNNGL-----------GDRGLRLLAKGL-KDLPPALekLVL 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 689 GQvenlsfksRKCGDAFAEALCRSLPTMGSLKTLGLTGSRITAQGISHLIQTLPLCSQLEEVSLHDNQLKDPEVLSLVEL 768
Cdd:cd00116 145 GR--------NRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAET 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 769 LPSLPKLQKLDLSRNSFSRSILLSLvkvaitcptvrklqvreldlifylspvtetatqqsgasdvqgKDSLKEGQSRSLQ 848
Cdd:cd00116 217 LASLKSLEVLNLGDNNLTDAGAAAL------------------------------------------ASALLSPNISLLT 254
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 755526967 849 LRLQKCQLRIRDAEALVELFQKSPQLEEVNLSGNHLEDDGCRLVAEA 895
Cdd:cd00116 255 LSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAES 301
|
|
| NLRC4_HD2 super family |
cl39284 |
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ... |
517-632 |
1.61e-09 |
|
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein. The actual alignment was detected with superfamily member pfam17776:
Pssm-ID: 436035 Cd Length: 122 Bit Score: 57.29 E-value: 1.61e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 517 HLSLQEFFAALYLMASHTVDK-DTLVEYVTLNSHWVLRT------KGRLGLSDHLPAFLAGLASHTCHMFL-----CQLA 584
Cdd:pfam17776 1 HLSFQEFFAALFYVLSFKEEKsNPLKEFLGLRKREELKSlldkalKSKNGHLDLFLRFLFGLLNEENQRLLegllgCKLS 80
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 755526967 585 QQDRAWvgsrqaaVIQVLRKLASRKLTGPKMIELYHCVAETQDLELAR 632
Cdd:pfam17776 81 SEIKQE-------LLQWIKSLIQKELSSERFLNLFHCLYELQDESFVK 121
|
|
| PPP1R42 super family |
cl42388 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
1007-1307 |
2.73e-06 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation. The actual alignment was detected with superfamily member cd00116:
Pssm-ID: 455733 [Multi-domain] Cd Length: 319 Bit Score: 51.59 E-value: 2.73e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 1007 HNLDHLDLSDNSLGGKGVILLTELLPGLGPLKSLNLSRNGLSMD--AVFSLVQCLSSLQWVFHLDVSlesDCIFLrgagt 1084
Cdd:cd00116 23 LCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGRIprGLQSLLQGLTKGCGLQELDLS---DNALG----- 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 1085 srdalepkfQTGVQVLE-LSQRYTSRSFCLQECQLEPTSLTFLCAtlekspGPLEVQLSCKSLsddslkILLQCLpqlpq 1163
Cdd:cd00116 95 ---------PDGCGVLEsLLRSSSLQELKLNNNGLGDRGLRLLAK------GLKDLPPALEKL------VLGRNR----- 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 1164 lsllqlrhtvLSSRSPFLLADIFNLCPRVRKVTL----------RSLCHAVLHFdsneeQEGVCCGFPGCSLSQEHMETL 1233
Cdd:cd00116 149 ----------LEGASCEALAKALRANRDLKELNLanngigdagiRALAEGLKAN-----CNLEVLDLNNNGLTDEGASAL 213
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755526967 1234 CCALSKCNALSQLDLTDNLLGDIGLRCLLECLPQLPIS-GWLDLSHNNISQEGILYLLETLPSYPNIQEVSVSLS 1307
Cdd:cd00116 214 AETLASLKSLEVLNLGDNNLTDAGAAALASALLSPNISlLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGN 288
|
|
| PPP1R42 super family |
cl42388 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
1766-1865 |
3.88e-03 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation. The actual alignment was detected with superfamily member cd21340:
Pssm-ID: 455733 [Multi-domain] Cd Length: 220 Bit Score: 40.92 E-value: 3.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 1766 LEQCPHIEEVSLAENNLAGGVP-RFSKR-----LPLLRQIDLEFCKIEDqaarhlAANLTLFPALEKLLLSGNLLGDevA 1839
Cdd:cd21340 86 LENLTNLEELHIENQRLPPGEKlTFDPRslaalSNSLRVLNISGNNIDS------LEPLAPLRNLEQLDASNNQISD--L 157
|
90 100
....*....|....*....|....*.
gi 755526967 1840 AELAQVLPQMGQLKKVNLEWNRITAR 1865
Cdd:cd21340 158 EELLDLLSSWPSLRELDLTGNPVCKK 183
|
|
|
|
Name |
Accession |
Description |
Interval |
E-value |
| Atypical_Card |
pfam18461 |
Atypical caspase recruitment domain; The N-terminal effector domain found in NLRC5. It adopts ... |
1-94 |
5.61e-48 |
|
Atypical caspase recruitment domain; The N-terminal effector domain found in NLRC5. It adopts a six alpha-helix bundle with a general death fold. Structure and sequence analysis of the NLRC5-N indicate that it possesses a fold similar to the one of the death-fold domains; however, it displays significant differences in the number of core alpha-helices and their relative orientation. Hence, it is suggested that NLRC5 belongs to the caspase recruitment domain (CARD) subfamily as an atypical CARD.
Pssm-ID: 436519 Cd Length: 95 Bit Score: 166.36 E-value: 5.61e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 1 MDAESIRLNNENLWAWLVRLLSKNPEWLSAKLRSFLPTMDLDCSYEPSNP-EVIHRQLNRLFAQGMATWKSFINDLCFEL 79
Cdd:pfam18461 1 MDPESLQLGTENLWPWLVRLLSKNPEWLSAKVKFFLPNMDLGSSNEAPDPtQKVILQLDRLEAQGLATWQSFIHCVCMEL 80
|
90
....*....|....*
gi 755526967 80 DVPLDMEIPLVSIWG 94
Cdd:pfam18461 81 EVPLDLEVPLLSTWG 95
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1520-1782 |
4.48e-31 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 125.55 E-value: 4.48e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 1520 HHLEELDFSNNSLREEDTELLMGALQGTCRLKKLHLSFLPLGAS--SLALLIQGLSRMTLLQDLCLSHNQIGDVGTQCLA 1597
Cdd:cd00116 23 LCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGRIprGLQSLLQGLTKGCGLQELDLSDNALGPDGCGVLE 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 1598 AILpKLPELRKFDLSHNQIGDVGTQCLAAILPKLPE-LRKFNLSHNQIGHVGTQCLAAILPKLPELRKFDLSRNQIGDVG 1676
Cdd:cd00116 103 SLL-RSSSLQELKLNNNGLGDRGLRLLAKGLKDLPPaLEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAG 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 1677 TQCLAAILPKLPELRKFDLSGNRIGPAGGVQLVKSLTHFEHLEEIKLGNNALGEPTALELAQRLP---PQLRVLCLPSSH 1753
Cdd:cd00116 182 IRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALASALLspnISLLTLSLSCND 261
|
250 260
....*....|....*....|....*....
gi 755526967 1754 LGPEGALGLAQALEQCPHIEEVSLAENNL 1782
Cdd:cd00116 262 ITDDGAKDLAEVLAEKESLLELDLRGNKF 290
|
|
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
223-385 |
9.74e-31 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 119.72 E-value: 9.74e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 223 RVTVLLGKAGMGKTTLAYRLRWRWAQGQLDR-FQALFLFEFRQLNMITQLPTLPQLLFDLYLMPESEPDAVFQYLKENAQ 301
Cdd:pfam05729 1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQgFDFVFFLPCRELSRSGNARSLADLLFSQWPEPAAPVSEVWAVILELPE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 302 EVLLIFDGLDEALHADSVgTDNAGSALTLFSELCHGNLLPGCWVMTTSRPG---KLPSCVPtEAATVHMWGFDGLRVEKY 378
Cdd:pfam05729 81 RLLLILDGLDELVSDLGQ-LDGPCPVLTLLSSLLRKKLLPGASLLLTVRPDalrDLRRGLE-EPRYLEVRGFSESDRKQY 158
|
....*..
gi 755526967 379 VTCFFSD 385
Cdd:pfam05729 159 VRKYFSD 165
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
735-1045 |
1.54e-13 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 73.54 E-value: 1.54e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 735 SHLIQTLPLCSQLEEVSLHDNQLKDPEVLSLVELLPSLPKLQKLDLSRNSFSRS--ILLSLVKVAITCPTVRKLQVRELD 812
Cdd:cd00116 13 ERATELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGRIprGLQSLLQGLTKGCGLQELDLSDNA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 813 LIFYLSPVTETATQ----------QSGASDVQGK---DSLKEGQSRSLQLRLQKCQLRIRDAEALVELFQKSPQLEEVNL 879
Cdd:cd00116 93 LGPDGCGVLESLLRssslqelklnNNGLGDRGLRllaKGLKDLPPALEKLVLGRNRLEGASCEALAKALRANRDLKELNL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 880 SGNHLEDDGCRLVAEAASQLHIAQKLDLSDNGLSQTGVTYVLKAMSTCGTLEDLHIsllnntvvltfaqepreqeGSCKG 959
Cdd:cd00116 173 ANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNL-------------------GDNNL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 960 RAPLISFVSPVTSELSQRSRRIRLTHCGFLAKHTETLCEALRASCQthnLDHLDLSDNSLGGKGVILLTELLPGLGP-LK 1038
Cdd:cd00116 234 TDAGAAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKES---LLELDLRGNKFGEEGAQLLAESLLEPGNeLE 310
|
....*..
gi 755526967 1039 SLNLSRN 1045
Cdd:cd00116 311 SLWVKDD 317
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
611-895 |
3.05e-12 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 69.69 E-value: 3.05e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 611 TGPKMIELYHCVAETQDLELARFtaQSLPSRLSFHNFPLTHADLaalanilehrdDPIHLDFDGCPLePHCPEAL--VGC 688
Cdd:cd00116 79 KGCGLQELDLSDNALGPDGCGVL--ESLLRSSSLQELKLNNNGL-----------GDRGLRLLAKGL-KDLPPALekLVL 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 689 GQvenlsfksRKCGDAFAEALCRSLPTMGSLKTLGLTGSRITAQGISHLIQTLPLCSQLEEVSLHDNQLKDPEVLSLVEL 768
Cdd:cd00116 145 GR--------NRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAET 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 769 LPSLPKLQKLDLSRNSFSRSILLSLvkvaitcptvrklqvreldlifylspvtetatqqsgasdvqgKDSLKEGQSRSLQ 848
Cdd:cd00116 217 LASLKSLEVLNLGDNNLTDAGAAAL------------------------------------------ASALLSPNISLLT 254
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 755526967 849 LRLQKCQLRIRDAEALVELFQKSPQLEEVNLSGNHLEDDGCRLVAEA 895
Cdd:cd00116 255 LSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAES 301
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
1408-1736 |
5.38e-11 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 227223 [Multi-domain] Cd Length: 394 Bit Score: 66.92 E-value: 5.38e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 1408 LTELSISEIQRKLWLQLEFPHQ-EGNSDSMALRLAHCDLETehshlmIQLVETY--ARLQQLSLSQVSFNDNDGTSSKLL 1484
Cdd:COG4886 28 TTPQSINLNFPDSNLESVAVNRlALNLSSNTLLLLPSSLSR------LLSLDLLspSGISSLDGSENLLNLLPLPSLDLN 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 1485 QNILLSSCEL-----KSFRLTFSQVSTKSLTHLAFGLGHchHLEELDFSNNSLREEDTELlmGALQGtcrLKKLHLSFLP 1559
Cdd:COG4886 102 LNRLRSNISElleltNLTSLDLDNNNITDIPPLIGLLKS--NLKELDLSDNKIESLPSPL--RNLPN---LKNLDLSFND 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 1560 LgaSSLALLIQGLsrmTLLQDLCLSHNQIGDVgtQCLAAILPKLPELrkfDLSHNQIgdvgTQCLAAiLPKLPELRKFNL 1639
Cdd:COG4886 175 L--SDLPKLLSNL---SNLNNLDLSGNKISDL--PPEIELLSALEEL---DLSNNSI----IELLSS-LSNLKNLSGLEL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 1640 SHNQIghvgtQCLAAILPKLPELRKFDLSRNQIGDVGtqclaaILPKLPELRKFDLSGNRIGPAGGVQLVKSLTHFEHLE 1719
Cdd:COG4886 240 SNNKL-----EDLPESIGNLSNLETLDLSNNQISSIS------SLGSLTNLRELDLSGNSLSNALPLIALLLLLLELLLN 308
|
330
....*....|....*..
gi 755526967 1720 EIKLGNNALGEPTALEL 1736
Cdd:COG4886 309 LLLTLKALELKLNSILL 325
|
|
| NLRC4_HD2 |
pfam17776 |
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ... |
517-632 |
1.61e-09 |
|
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.
Pssm-ID: 436035 Cd Length: 122 Bit Score: 57.29 E-value: 1.61e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 517 HLSLQEFFAALYLMASHTVDK-DTLVEYVTLNSHWVLRT------KGRLGLSDHLPAFLAGLASHTCHMFL-----CQLA 584
Cdd:pfam17776 1 HLSFQEFFAALFYVLSFKEEKsNPLKEFLGLRKREELKSlldkalKSKNGHLDLFLRFLFGLLNEENQRLLegllgCKLS 80
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 755526967 585 QQDRAWvgsrqaaVIQVLRKLASRKLTGPKMIELYHCVAETQDLELAR 632
Cdd:pfam17776 81 SEIKQE-------LLQWIKSLIQKELSSERFLNLFHCLYELQDESFVK 121
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1007-1307 |
2.73e-06 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 51.59 E-value: 2.73e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 1007 HNLDHLDLSDNSLGGKGVILLTELLPGLGPLKSLNLSRNGLSMD--AVFSLVQCLSSLQWVFHLDVSlesDCIFLrgagt 1084
Cdd:cd00116 23 LCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGRIprGLQSLLQGLTKGCGLQELDLS---DNALG----- 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 1085 srdalepkfQTGVQVLE-LSQRYTSRSFCLQECQLEPTSLTFLCAtlekspGPLEVQLSCKSLsddslkILLQCLpqlpq 1163
Cdd:cd00116 95 ---------PDGCGVLEsLLRSSSLQELKLNNNGLGDRGLRLLAK------GLKDLPPALEKL------VLGRNR----- 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 1164 lsllqlrhtvLSSRSPFLLADIFNLCPRVRKVTL----------RSLCHAVLHFdsneeQEGVCCGFPGCSLSQEHMETL 1233
Cdd:cd00116 149 ----------LEGASCEALAKALRANRDLKELNLanngigdagiRALAEGLKAN-----CNLEVLDLNNNGLTDEGASAL 213
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755526967 1234 CCALSKCNALSQLDLTDNLLGDIGLRCLLECLPQLPIS-GWLDLSHNNISQEGILYLLETLPSYPNIQEVSVSLS 1307
Cdd:cd00116 214 AETLASLKSLEVLNLGDNNLTDAGAAALASALLSPNISlLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGN 288
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
1604-1672 |
2.83e-05 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 43.28 E-value: 2.83e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755526967 1604 PELRKFDLSHNQIGDVGTQCLAailpKLPELRKFNLSHNQIGHVGTQCLAailpKLPELRKFDLSRNQI 1672
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFK----GLSNLKVLDLSNNLLTTLSPGAFS----GLPSLRYLDLSGNRL 61
|
|
| COG5635 |
COG5635 |
Predicted NTPase, NACHT family domain [Signal transduction mechanisms]; |
226-533 |
5.37e-05 |
|
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
Pssm-ID: 227922 [Multi-domain] Cd Length: 824 Bit Score: 48.25 E-value: 5.37e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 226 VLLGKAGMGKTTLAYRLRWRWAQGQL-----DRFQALFLFEF-----RQLNMItqlPTLPQLLFDLYLMPEsEPDAVFQY 295
Cdd:COG5635 226 LILGAPGSGKTTFLQRLALWLAQRTLepedvPIFLLLNAFALarkfeKQLSLI---DYLAEELFSQGIAKQ-LIEAHQEL 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 296 LKEnaQEVLLIFDGLDEALhadSVGTDNAGSALTLFSELCHGNLlpgcwVMTTSRPGKLPScVPTEAATVHMWGFDGLRV 375
Cdd:COG5635 302 LKT--GKLLLLLDGLDELE---PKNQRALIREINKFLQEYPDAQ-----VLLTCRPDTYKE-EFKGFAVFEIYKFLDLQI 370
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 376 EKYVTCFFSDL---------------LSQELALKEMRtnaRLRGMCAIPALCTVTC--FCLRRLLPGSSPGqsaallpti 438
Cdd:COG5635 371 NQFILYQWLDAfiedwfgdsrllakkLLERLKLPENR---RIKELALTPLLLALECliWQAQGDLPESRAE--------- 438
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 439 tqLYLQMVETFSPSEtllDTSILGFGKVALRGLDTG---KVVFS-----------------------VEDISPQLMSFGA 492
Cdd:COG5635 439 --LYEQAVDALLGRE---DETRGIKWSKTYAKLTTDqqdKWLLQllaallfekldeeftefllkddiVDYLLNQAEDEDD 513
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 755526967 493 VHSL---LTSFCIHTRPG----HEEIGYAFVHLSLQEFFAALYLMASH 533
Cdd:COG5635 514 LIALalaLEALLKLLQHGllveRAKIVYAFAHATFQEYFAAKKIVASS 561
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Signal ... |
713-933 |
1.33e-04 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Signal transduction mechanisms, RNA processing and modification];
Pssm-ID: 227563 [Multi-domain] Cd Length: 388 Bit Score: 46.46 E-value: 1.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 713 LPTMGSLKTLGLTGSRITAQGISHLIQTLPLCSQLEEVSLHD---NQLKDPEVLSLVELLPSL---PKLQKLDLSRNSFS 786
Cdd:COG5238 26 LEMMDELVEVDLSGNTIGTEAMEELCNVIANVRNLRVVNFSDaftGRDKDELYSNLVMLLKALlkcPRLQKVDLSDNAFG 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 787 RSILLSLVkvaitcptvrklqvrelDLIFYLSPVTETATQQSG----ASDVQGKDSLKEGQSRSLQ----LRLQKC-QLR 857
Cdd:COG5238 106 SEFPEELG-----------------DLISSSTDLVHLKLNNNGlgpiAGGRIGKALFHLAYNKKAAdkpkLEVVICgRNR 168
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755526967 858 IRD--AEALVELFQKSPQLEEVNLSGNHLEDDGCR-LVAEAASQLHIAQKLDLSDNGLSQTGVTYVLKAMSTCGTLEDL 933
Cdd:COG5238 169 LENgsKELSAALLESHENLKEVKIQQNGIRPEGVTmLAFLGLFYSHSLEVLDLQDNTFTLEGSRYLADALCEWNLLREL 247
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
1766-1865 |
3.88e-03 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 40.92 E-value: 3.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 1766 LEQCPHIEEVSLAENNLAGGVP-RFSKR-----LPLLRQIDLEFCKIEDqaarhlAANLTLFPALEKLLLSGNLLGDevA 1839
Cdd:cd21340 86 LENLTNLEELHIENQRLPPGEKlTFDPRslaalSNSLRVLNISGNNIDS------LEPLAPLRNLEQLDASNNQISD--L 157
|
90 100
....*....|....*....|....*.
gi 755526967 1840 AELAQVLPQMGQLKKVNLEWNRITAR 1865
Cdd:cd21340 158 EELLDLLSSWPSLRELDLTGNPVCKK 183
|
|
| LRR_4 |
pfam12799 |
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ... |
746-789 |
5.19e-03 |
|
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.
Pssm-ID: 432794 [Multi-domain] Cd Length: 44 Bit Score: 36.45 E-value: 5.19e-03
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 755526967 746 QLEEVSLHDNQLKDpevlslVELLPSLPKLQKLDLSRNSFSRSI 789
Cdd:pfam12799 2 NLEVLDLSNNQITD------LPPLAKLPNLETLDLSGNNKITDL 39
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
1630-1901 |
7.69e-03 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 41.37 E-value: 7.69e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 1630 KLPELRKFNLSHNQIGhvgTQCLAAILPKLPELRKFDLSRNQigdvgtqcLAAILPK--LPELRKFDLSGNRIGPaggvQ 1707
Cdd:PLN00113 91 RLPYIQTINLSNNQLS---GPIPDDIFTTSSSLRYLNLSNNN--------FTGSIPRgsIPNLETLDLSNNMLSG----E 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 1708 LVKSLTHFEHLEEIKLGNNALGEPTALELAQRlpPQLRVLCLPSSHLgpegALGLAQALEQCPHIEEVSLAENNLAGGVP 1787
Cdd:PLN00113 156 IPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNL--TSLEFLTLASNQL----VGQIPRELGQMKSLKWIYLGYNNLSGEIP 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 1788 RFSKRLPLLRQIDLEFCKIEDQAARHLaANLT----LFPALEKL-------------LLSGNLLGDEVAAELAQVLPQMG 1850
Cdd:PLN00113 230 YEIGGLTSLNHLDLVYNNLTGPIPSSL-GNLKnlqyLFLYQNKLsgpippsifslqkLISLDLSDNSLSGEIPELVIQLQ 308
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 755526967 1851 QLKKVNLEWNRITARgaqlLAQGLVQGSCVPVIRLWNNPILNDVAQSLQSQ 1901
Cdd:PLN00113 309 NLEILHLFSNNFTGK----IPVALTSLPRLQVLQLWSNKFSGEIPKNLGKH 355
|
|
|
|
Name |
Accession |
Description |
Interval |
E-value |
| Atypical_Card |
pfam18461 |
Atypical caspase recruitment domain; The N-terminal effector domain found in NLRC5. It adopts ... |
1-94 |
5.61e-48 |
|
Atypical caspase recruitment domain; The N-terminal effector domain found in NLRC5. It adopts a six alpha-helix bundle with a general death fold. Structure and sequence analysis of the NLRC5-N indicate that it possesses a fold similar to the one of the death-fold domains; however, it displays significant differences in the number of core alpha-helices and their relative orientation. Hence, it is suggested that NLRC5 belongs to the caspase recruitment domain (CARD) subfamily as an atypical CARD.
Pssm-ID: 436519 Cd Length: 95 Bit Score: 166.36 E-value: 5.61e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 1 MDAESIRLNNENLWAWLVRLLSKNPEWLSAKLRSFLPTMDLDCSYEPSNP-EVIHRQLNRLFAQGMATWKSFINDLCFEL 79
Cdd:pfam18461 1 MDPESLQLGTENLWPWLVRLLSKNPEWLSAKVKFFLPNMDLGSSNEAPDPtQKVILQLDRLEAQGLATWQSFIHCVCMEL 80
|
90
....*....|....*
gi 755526967 80 DVPLDMEIPLVSIWG 94
Cdd:pfam18461 81 EVPLDLEVPLLSTWG 95
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1520-1782 |
4.48e-31 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 125.55 E-value: 4.48e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 1520 HHLEELDFSNNSLREEDTELLMGALQGTCRLKKLHLSFLPLGAS--SLALLIQGLSRMTLLQDLCLSHNQIGDVGTQCLA 1597
Cdd:cd00116 23 LCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGRIprGLQSLLQGLTKGCGLQELDLSDNALGPDGCGVLE 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 1598 AILpKLPELRKFDLSHNQIGDVGTQCLAAILPKLPE-LRKFNLSHNQIGHVGTQCLAAILPKLPELRKFDLSRNQIGDVG 1676
Cdd:cd00116 103 SLL-RSSSLQELKLNNNGLGDRGLRLLAKGLKDLPPaLEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAG 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 1677 TQCLAAILPKLPELRKFDLSGNRIGPAGGVQLVKSLTHFEHLEEIKLGNNALGEPTALELAQRLP---PQLRVLCLPSSH 1753
Cdd:cd00116 182 IRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALASALLspnISLLTLSLSCND 261
|
250 260
....*....|....*....|....*....
gi 755526967 1754 LGPEGALGLAQALEQCPHIEEVSLAENNL 1782
Cdd:cd00116 262 ITDDGAKDLAEVLAEKESLLELDLRGNKF 290
|
|
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
223-385 |
9.74e-31 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 119.72 E-value: 9.74e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 223 RVTVLLGKAGMGKTTLAYRLRWRWAQGQLDR-FQALFLFEFRQLNMITQLPTLPQLLFDLYLMPESEPDAVFQYLKENAQ 301
Cdd:pfam05729 1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQgFDFVFFLPCRELSRSGNARSLADLLFSQWPEPAAPVSEVWAVILELPE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 302 EVLLIFDGLDEALHADSVgTDNAGSALTLFSELCHGNLLPGCWVMTTSRPG---KLPSCVPtEAATVHMWGFDGLRVEKY 378
Cdd:pfam05729 81 RLLLILDGLDELVSDLGQ-LDGPCPVLTLLSSLLRKKLLPGASLLLTVRPDalrDLRRGLE-EPRYLEVRGFSESDRKQY 158
|
....*..
gi 755526967 379 VTCFFSD 385
Cdd:pfam05729 159 VRKYFSD 165
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1522-1768 |
3.65e-28 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 117.07 E-value: 3.65e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 1522 LEELDFSNNSLREED--TELLMGALQGTCRLKKLHLSFLPLGASSLALLiQGLSRMTLLQDLCLSHNQIGDVGTQCLAAI 1599
Cdd:cd00116 53 LKELCLSLNETGRIPrgLQSLLQGLTKGCGLQELDLSDNALGPDGCGVL-ESLLRSSSLQELKLNNNGLGDRGLRLLAKG 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 1600 LPKLPE-LRKFDLSHNQIGDVGTQCLAAILPKLPELRKFNLSHNQIGHVGTQCLAAILPKLPELRKFDLSRNQIGDVGTQ 1678
Cdd:cd00116 132 LKDLPPaLEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGAS 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 1679 CLAAILPKLPELRKFDLSGNRIGPAGGVQLVKSLTHFEH-LEEIKLGNNALGEPTALELAQRLP--PQLRVLCLPSSHLG 1755
Cdd:cd00116 212 ALAETLASLKSLEVLNLGDNNLTDAGAAALASALLSPNIsLLTLSLSCNDITDDGAKDLAEVLAekESLLELDLRGNKFG 291
|
250
....*....|...
gi 755526967 1756 PEGALGLAQALEQ 1768
Cdd:cd00116 292 EEGAQLLAESLLE 304
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1578-1887 |
1.51e-27 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 115.53 E-value: 1.51e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 1578 LQDLCLSHNQIGDVGTQCLAAILPKLPELRKFDLSHNQIG--DVGTQCLAAILPKLPELRKFNLSHNQIGHVGTQCLAAI 1655
Cdd:cd00116 25 LQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGriPRGLQSLLQGLTKGCGLQELDLSDNALGPDGCGVLESL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 1656 LpKLPELRKFDLSRNQIGDVGTQCLAAILPKLPE-LRKFDLSGNRIGPAGGVQLVKSLTHFEHLEEIKLGNNALGEPTAL 1734
Cdd:cd00116 105 L-RSSSLQELKLNNNGLGDRGLRLLAKGLKDLPPaLEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIR 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 1735 ELAQRLP--PQLRVLCLPSSHLGPEGALGLAQALEQcphieevslaennlaggvprfskrLPLLRQIDLEFCKIEDQAAR 1812
Cdd:cd00116 184 ALAEGLKanCNLEVLDLNNNGLTDEGASALAETLAS------------------------LKSLEVLNLGDNNLTDAGAA 239
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755526967 1813 HLA-ANLTLFPALEKLLLSGNLLGDEVAAELAQVLPQMGQLKKVNLEWNRITARGAQLLAQGLVQGSCVPvIRLWN 1887
Cdd:cd00116 240 ALAsALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLLEPGNEL-ESLWV 314
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1437-1684 |
1.78e-25 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 109.37 E-value: 1.78e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 1437 ALRLAHCDLETEHS----HLMIQLVETYARLQQLSLSQVSFNDndgTSSKLLQNILLSScELKSFRLTFSQVSTKSLTHL 1512
Cdd:cd00116 53 LKELCLSLNETGRIprglQSLLQGLTKGCGLQELDLSDNALGP---DGCGVLESLLRSS-SLQELKLNNNGLGDRGLRLL 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 1513 AFGLGHC-HHLEELDFSNNSLREEDTELLMGALQGTCRLKKLHLSFLPLGASSLALLIQGLSRMTLLQDLCLSHNQIGDV 1591
Cdd:cd00116 129 AKGLKDLpPALEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDE 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 1592 GTQCLAAILPKLPELRKFDLSHNQIGDVGTQCLAAILPKL-PELRKFNLSHNQIGHVGTQCLAAILPKLPELRKFDLSRN 1670
Cdd:cd00116 209 GASALAETLASLKSLEVLNLGDNNLTDAGAAALASALLSPnISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGN 288
|
250
....*....|....
gi 755526967 1671 QIGDVGTQCLAAIL 1684
Cdd:cd00116 289 KFGEEGAQLLAESL 302
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1627-1898 |
2.79e-21 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 97.04 E-value: 2.79e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 1627 ILPKLPELRKFNLSHNQIGHVGTQCLAAILPKLPELRKFDLSRNQIG--DVGTQCLAAILPKLPELRKFDLSGNRIGPAG 1704
Cdd:cd00116 18 LLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGriPRGLQSLLQGLTKGCGLQELDLSDNALGPDG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 1705 gVQLVKSLTHFEHLEEIKLGNNALGePTALELAQR----LPPQLRVLCLPSSHLGPEGALGLAQALEQCPHIEEVSLAEN 1780
Cdd:cd00116 98 -CGVLESLLRSSSLQELKLNNNGLG-DRGLRLLAKglkdLPPALEKLVLGRNRLEGASCEALAKALRANRDLKELNLANN 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 1781 NlaggvprfskrlpllrqidlefckIEDQAARHLAANLTLFPALEKLLLSGNLLGDEVAAELAQVLPQMGQLKKVNLEWN 1860
Cdd:cd00116 176 G------------------------IGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDN 231
|
250 260 270
....*....|....*....|....*....|....*....
gi 755526967 1861 RITARGAQLLAQGLVQGS-CVPVIRLWNNPILNDVAQSL 1898
Cdd:cd00116 232 NLTDAGAAALASALLSPNiSLLTLSLSCNDITDDGAKDL 270
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
735-1045 |
1.54e-13 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 73.54 E-value: 1.54e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 735 SHLIQTLPLCSQLEEVSLHDNQLKDPEVLSLVELLPSLPKLQKLDLSRNSFSRS--ILLSLVKVAITCPTVRKLQVRELD 812
Cdd:cd00116 13 ERATELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGRIprGLQSLLQGLTKGCGLQELDLSDNA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 813 LIFYLSPVTETATQ----------QSGASDVQGK---DSLKEGQSRSLQLRLQKCQLRIRDAEALVELFQKSPQLEEVNL 879
Cdd:cd00116 93 LGPDGCGVLESLLRssslqelklnNNGLGDRGLRllaKGLKDLPPALEKLVLGRNRLEGASCEALAKALRANRDLKELNL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 880 SGNHLEDDGCRLVAEAASQLHIAQKLDLSDNGLSQTGVTYVLKAMSTCGTLEDLHIsllnntvvltfaqepreqeGSCKG 959
Cdd:cd00116 173 ANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNL-------------------GDNNL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 960 RAPLISFVSPVTSELSQRSRRIRLTHCGFLAKHTETLCEALRASCQthnLDHLDLSDNSLGGKGVILLTELLPGLGP-LK 1038
Cdd:cd00116 234 TDAGAAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKES---LLELDLRGNKFGEEGAQLLAESLLEPGNeLE 310
|
....*..
gi 755526967 1039 SLNLSRN 1045
Cdd:cd00116 311 SLWVKDD 317
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
611-895 |
3.05e-12 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 69.69 E-value: 3.05e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 611 TGPKMIELYHCVAETQDLELARFtaQSLPSRLSFHNFPLTHADLaalanilehrdDPIHLDFDGCPLePHCPEAL--VGC 688
Cdd:cd00116 79 KGCGLQELDLSDNALGPDGCGVL--ESLLRSSSLQELKLNNNGL-----------GDRGLRLLAKGL-KDLPPALekLVL 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 689 GQvenlsfksRKCGDAFAEALCRSLPTMGSLKTLGLTGSRITAQGISHLIQTLPLCSQLEEVSLHDNQLKDPEVLSLVEL 768
Cdd:cd00116 145 GR--------NRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAET 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 769 LPSLPKLQKLDLSRNSFSRSILLSLvkvaitcptvrklqvreldlifylspvtetatqqsgasdvqgKDSLKEGQSRSLQ 848
Cdd:cd00116 217 LASLKSLEVLNLGDNNLTDAGAAAL------------------------------------------ASALLSPNISLLT 254
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 755526967 849 LRLQKCQLRIRDAEALVELFQKSPQLEEVNLSGNHLEDDGCRLVAEA 895
Cdd:cd00116 255 LSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAES 301
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
848-1118 |
3.07e-11 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 66.61 E-value: 3.07e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 848 QLRLQKCQLRIRDAEALVELFQKSPQLEEVNLSGNHLE--DDGCRLVAEAASQLHIAQKLDLSDNGLSQTGVTyVLKAMS 925
Cdd:cd00116 27 VLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGriPRGLQSLLQGLTKGCGLQELDLSDNALGPDGCG-VLESLL 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 926 TCGTLEDLHisLLNNTvvLTFAQEPREQEGSCKGRAPLISFV-----------SPVTSELS--QRSRRIRLTHCGFLAKH 992
Cdd:cd00116 106 RSSSLQELK--LNNNG--LGDRGLRLLAKGLKDLPPALEKLVlgrnrlegascEALAKALRanRDLKELNLANNGIGDAG 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 993 TETLCEALRASCqthNLDHLDLSDNSLGGKGVILLTELLPGLGPLKSLNLSRNGLSMDAVFSLVQCLSSLQWVFhLDVSL 1072
Cdd:cd00116 182 IRALAEGLKANC---NLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALASALLSPNISL-LTLSL 257
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 755526967 1073 ESDCIFLRGAGTSRDALEPKFQtgVQVLELSQRYTSRSFCLQECQL 1118
Cdd:cd00116 258 SCNDITDDGAKDLAEVLAEKES--LLELDLRGNKFGEEGAQLLAES 301
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
1408-1736 |
5.38e-11 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 227223 [Multi-domain] Cd Length: 394 Bit Score: 66.92 E-value: 5.38e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 1408 LTELSISEIQRKLWLQLEFPHQ-EGNSDSMALRLAHCDLETehshlmIQLVETY--ARLQQLSLSQVSFNDNDGTSSKLL 1484
Cdd:COG4886 28 TTPQSINLNFPDSNLESVAVNRlALNLSSNTLLLLPSSLSR------LLSLDLLspSGISSLDGSENLLNLLPLPSLDLN 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 1485 QNILLSSCEL-----KSFRLTFSQVSTKSLTHLAFGLGHchHLEELDFSNNSLREEDTELlmGALQGtcrLKKLHLSFLP 1559
Cdd:COG4886 102 LNRLRSNISElleltNLTSLDLDNNNITDIPPLIGLLKS--NLKELDLSDNKIESLPSPL--RNLPN---LKNLDLSFND 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 1560 LgaSSLALLIQGLsrmTLLQDLCLSHNQIGDVgtQCLAAILPKLPELrkfDLSHNQIgdvgTQCLAAiLPKLPELRKFNL 1639
Cdd:COG4886 175 L--SDLPKLLSNL---SNLNNLDLSGNKISDL--PPEIELLSALEEL---DLSNNSI----IELLSS-LSNLKNLSGLEL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 1640 SHNQIghvgtQCLAAILPKLPELRKFDLSRNQIGDVGtqclaaILPKLPELRKFDLSGNRIGPAGGVQLVKSLTHFEHLE 1719
Cdd:COG4886 240 SNNKL-----EDLPESIGNLSNLETLDLSNNQISSIS------SLGSLTNLRELDLSGNSLSNALPLIALLLLLLELLLN 308
|
330
....*....|....*..
gi 755526967 1720 EIKLGNNALGEPTALEL 1736
Cdd:COG4886 309 LLLTLKALELKLNSILL 325
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
1507-1700 |
1.48e-10 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 62.88 E-value: 1.48e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 1507 KSLTHLAF---------GLGHCHHLEELDFSNNSLREedtellMGALQGTCRLKKLHLS--FLplgaSSlallIQGLSRM 1575
Cdd:cd21340 2 KRITHLYLndknitkidNLSLCKNLKVLYLYDNKITK------IENLEFLTNLTHLYLQnnQI----EK----IENLENL 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 1576 TLLQDLCLSHNQIGDV-GtqclaaiLPKLPELRKFDLSHNQIGD-----VGTQCLAAIlpkLPELRKFNLSHNQIghvgt 1649
Cdd:cd21340 68 VNLKKLYLGGNRISVVeG-------LENLTNLEELHIENQRLPPgekltFDPRSLAAL---SNSLRVLNISGNNI----- 132
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 755526967 1650 QCLAAILPkLPELRKFDLSRNQIGDVgtQCLAAILPKLPELRKFDLSGNRI 1700
Cdd:cd21340 133 DSLEPLAP-LRNLEQLDASNNQISDL--EELLDLLSSWPSLRELDLTGNPV 180
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
847-1156 |
7.08e-10 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 62.37 E-value: 7.08e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 847 LQLRLQKCQLRIRDAEalvELFQKSPQLEEVNLSGNHLEDDGCRLVAEAASQLHIAQKLDLSDN--GLSQTGVTYVLKAM 924
Cdd:cd00116 1 LQLSLKGELLKTERAT---ELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNetGRIPRGLQSLLQGL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 925 STCGTLEdlHISLLNNTvvLTFAqepreqegsckGRAPLISFVSPVTSELSQrsrrirLTHCGFLAKHTETLCEALRaSC 1004
Cdd:cd00116 78 TKGCGLQ--ELDLSDNA--LGPD-----------GCGVLESLLRSSSLQELK------LNNNGLGDRGLRLLAKGLK-DL 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 1005 QtHNLDHLDLSDNSLGGKGVILLTELLPGLGPLKSLNLSRNGLSMDAVFSLVQCLSSLQWVFHLDvsLESDCIFLRGAGT 1084
Cdd:cd00116 136 P-PALEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLD--LNNNGLTDEGASA 212
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755526967 1085 SRDALEPKFQtgVQVLELSQrytsrsfCLqeCQLEPTSlTFLCATLEKSPGPLEVQLSCKSLSDDSLKILLQ 1156
Cdd:cd00116 213 LAETLASLKS--LEVLNLGD-------NN--LTDAGAA-ALASALLSPNISLLTLSLSCNDITDDGAKDLAE 272
|
|
| NLRC4_HD2 |
pfam17776 |
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ... |
517-632 |
1.61e-09 |
|
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.
Pssm-ID: 436035 Cd Length: 122 Bit Score: 57.29 E-value: 1.61e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 517 HLSLQEFFAALYLMASHTVDK-DTLVEYVTLNSHWVLRT------KGRLGLSDHLPAFLAGLASHTCHMFL-----CQLA 584
Cdd:pfam17776 1 HLSFQEFFAALFYVLSFKEEKsNPLKEFLGLRKREELKSlldkalKSKNGHLDLFLRFLFGLLNEENQRLLegllgCKLS 80
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 755526967 585 QQDRAWvgsrqaaVIQVLRKLASRKLTGPKMIELYHCVAETQDLELAR 632
Cdd:pfam17776 81 SEIKQE-------LLQWIKSLIQKELSSERFLNLFHCLYELQDESFVK 121
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Signal ... |
1598-1862 |
1.38e-07 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Signal transduction mechanisms, RNA processing and modification];
Pssm-ID: 227563 [Multi-domain] Cd Length: 388 Bit Score: 56.09 E-value: 1.38e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 1598 AILPKLPELRKFDLSHNQIGDVGTQCLAAILPKLPELRKFNLSHNQIGHVGTQC------LAAILPKLPELRKFDLSRNQ 1671
Cdd:COG5238 24 EELEMMDELVEVDLSGNTIGTEAMEELCNVIANVRNLRVVNFSDAFTGRDKDELysnlvmLLKALLKCPRLQKVDLSDNA 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 1672 IGDVGTQCLAAILPKLPELRKFDLSGNRIGPAGGVQLVKSLTHFEH---------LEEIKLGNNALGEPTALELAQRLPP 1742
Cdd:COG5238 104 FGSEFPEELGDLISSSTDLVHLKLNNNGLGPIAGGRIGKALFHLAYnkkaadkpkLEVVICGRNRLENGSKELSAALLES 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 1743 Q--LRVLCLPSSHLGPEGALGLA-QALEQCPHIEEVSLAENNLAGGVPRFSKRL----PLLRQIDLEFCKIEDQAARHL- 1814
Cdd:COG5238 184 HenLKEVKIQQNGIRPEGVTMLAfLGLFYSHSLEVLDLQDNTFTLEGSRYLADAlcewNLLRELRLNDCLLSNEGVKSVl 263
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 755526967 1815 -AANLTLFPALEKLLLSGNLLgdEVAAELAQVLPQMGQ-----LKKVNLEWNRI 1862
Cdd:COG5238 264 rRFNEKFVPNLMPLPGDYNER--RGGIILDISLNEFEQdavplLVDLERNGNRI 315
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1007-1307 |
2.73e-06 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 51.59 E-value: 2.73e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 1007 HNLDHLDLSDNSLGGKGVILLTELLPGLGPLKSLNLSRNGLSMD--AVFSLVQCLSSLQWVFHLDVSlesDCIFLrgagt 1084
Cdd:cd00116 23 LCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGRIprGLQSLLQGLTKGCGLQELDLS---DNALG----- 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 1085 srdalepkfQTGVQVLE-LSQRYTSRSFCLQECQLEPTSLTFLCAtlekspGPLEVQLSCKSLsddslkILLQCLpqlpq 1163
Cdd:cd00116 95 ---------PDGCGVLEsLLRSSSLQELKLNNNGLGDRGLRLLAK------GLKDLPPALEKL------VLGRNR----- 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 1164 lsllqlrhtvLSSRSPFLLADIFNLCPRVRKVTL----------RSLCHAVLHFdsneeQEGVCCGFPGCSLSQEHMETL 1233
Cdd:cd00116 149 ----------LEGASCEALAKALRANRDLKELNLanngigdagiRALAEGLKAN-----CNLEVLDLNNNGLTDEGASAL 213
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755526967 1234 CCALSKCNALSQLDLTDNLLGDIGLRCLLECLPQLPIS-GWLDLSHNNISQEGILYLLETLPSYPNIQEVSVSLS 1307
Cdd:cd00116 214 AETLASLKSLEVLNLGDNNLTDAGAAALASALLSPNISlLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGN 288
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Signal ... |
1522-1837 |
4.32e-06 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Signal transduction mechanisms, RNA processing and modification];
Pssm-ID: 227563 [Multi-domain] Cd Length: 388 Bit Score: 51.08 E-value: 4.32e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 1522 LEELDFSNNSLREEDTELLMGALQGTCRLKKLHLSFLPLG------ASSLALLIQGLSrmtllqdlclshnqigdvgtqc 1595
Cdd:COG5238 32 LVEVDLSGNTIGTEAMEELCNVIANVRNLRVVNFSDAFTGrdkdelYSNLVMLLKALL---------------------- 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 1596 laailpKLPELRKFDLSHNQIGDVGTQCLAAILPKLPELRKFNLSHNQIGHVGTQCLAAILPKLPELRKfdlsrnqigdv 1675
Cdd:COG5238 90 ------KCPRLQKVDLSDNAFGSEFPEELGDLISSSTDLVHLKLNNNGLGPIAGGRIGKALFHLAYNKK----------- 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 1676 gtqclAAILPKlpeLRKFDLSGNRIGPAGGVQLVKSLTHFEHLEEIKLGNNALGEPT----ALELAQRLpPQLRVLCLPS 1751
Cdd:COG5238 153 -----AADKPK---LEVVICGRNRLENGSKELSAALLESHENLKEVKIQQNGIRPEGvtmlAFLGLFYS-HSLEVLDLQD 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 1752 SHLGPEGALGLAQALEQCPHIEEVSLAENNL-AGGVPRFSKRL-----PLLRQIDLEFCKIEDQAARHLAANLTL---FP 1822
Cdd:COG5238 224 NTFTLEGSRYLADALCEWNLLRELRLNDCLLsNEGVKSVLRRFnekfvPNLMPLPGDYNERRGGIILDISLNEFEqdaVP 303
|
330
....*....|....*
gi 755526967 1823 ALEKLLLSGNLLGDE 1837
Cdd:COG5238 304 LLVDLERNGNRIKEL 318
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
1604-1672 |
2.83e-05 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 43.28 E-value: 2.83e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755526967 1604 PELRKFDLSHNQIGDVGTQCLAailpKLPELRKFNLSHNQIGHVGTQCLAailpKLPELRKFDLSRNQI 1672
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFK----GLSNLKVLDLSNNLLTTLSPGAFS----GLPSLRYLDLSGNRL 61
|
|
| COG5635 |
COG5635 |
Predicted NTPase, NACHT family domain [Signal transduction mechanisms]; |
226-533 |
5.37e-05 |
|
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
Pssm-ID: 227922 [Multi-domain] Cd Length: 824 Bit Score: 48.25 E-value: 5.37e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 226 VLLGKAGMGKTTLAYRLRWRWAQGQL-----DRFQALFLFEF-----RQLNMItqlPTLPQLLFDLYLMPEsEPDAVFQY 295
Cdd:COG5635 226 LILGAPGSGKTTFLQRLALWLAQRTLepedvPIFLLLNAFALarkfeKQLSLI---DYLAEELFSQGIAKQ-LIEAHQEL 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 296 LKEnaQEVLLIFDGLDEALhadSVGTDNAGSALTLFSELCHGNLlpgcwVMTTSRPGKLPScVPTEAATVHMWGFDGLRV 375
Cdd:COG5635 302 LKT--GKLLLLLDGLDELE---PKNQRALIREINKFLQEYPDAQ-----VLLTCRPDTYKE-EFKGFAVFEIYKFLDLQI 370
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 376 EKYVTCFFSDL---------------LSQELALKEMRtnaRLRGMCAIPALCTVTC--FCLRRLLPGSSPGqsaallpti 438
Cdd:COG5635 371 NQFILYQWLDAfiedwfgdsrllakkLLERLKLPENR---RIKELALTPLLLALECliWQAQGDLPESRAE--------- 438
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 439 tqLYLQMVETFSPSEtllDTSILGFGKVALRGLDTG---KVVFS-----------------------VEDISPQLMSFGA 492
Cdd:COG5635 439 --LYEQAVDALLGRE---DETRGIKWSKTYAKLTTDqqdKWLLQllaallfekldeeftefllkddiVDYLLNQAEDEDD 513
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 755526967 493 VHSL---LTSFCIHTRPG----HEEIGYAFVHLSLQEFFAALYLMASH 533
Cdd:COG5635 514 LIALalaLEALLKLLQHGllveRAKIVYAFAHATFQEYFAAKKIVASS 561
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
1632-1700 |
8.35e-05 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 42.13 E-value: 8.35e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755526967 1632 PELRKFNLSHNQIGHVGTQCLAailpKLPELRKFDLSRNQIGDVGTQCLAailpKLPELRKFDLSGNRI 1700
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFK----GLSNLKVLDLSNNLLTTLSPGAFS----GLPSLRYLDLSGNRL 61
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Signal ... |
713-933 |
1.33e-04 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Signal transduction mechanisms, RNA processing and modification];
Pssm-ID: 227563 [Multi-domain] Cd Length: 388 Bit Score: 46.46 E-value: 1.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 713 LPTMGSLKTLGLTGSRITAQGISHLIQTLPLCSQLEEVSLHD---NQLKDPEVLSLVELLPSL---PKLQKLDLSRNSFS 786
Cdd:COG5238 26 LEMMDELVEVDLSGNTIGTEAMEELCNVIANVRNLRVVNFSDaftGRDKDELYSNLVMLLKALlkcPRLQKVDLSDNAFG 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 787 RSILLSLVkvaitcptvrklqvrelDLIFYLSPVTETATQQSG----ASDVQGKDSLKEGQSRSLQ----LRLQKC-QLR 857
Cdd:COG5238 106 SEFPEELG-----------------DLISSSTDLVHLKLNNNGlgpiAGGRIGKALFHLAYNKKAAdkpkLEVVICgRNR 168
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755526967 858 IRD--AEALVELFQKSPQLEEVNLSGNHLEDDGCR-LVAEAASQLHIAQKLDLSDNGLSQTGVTYVLKAMSTCGTLEDL 933
Cdd:COG5238 169 LENgsKELSAALLESHENLKEVKIQQNGIRPEGVTmLAFLGLFYSHSLEVLDLQDNTFTLEGSRYLADALCEWNLLREL 247
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Signal ... |
1682-1871 |
1.57e-04 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Signal transduction mechanisms, RNA processing and modification];
Pssm-ID: 227563 [Multi-domain] Cd Length: 388 Bit Score: 46.07 E-value: 1.57e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 1682 AILPKLPELRKFDLSGNRIGPAGGVQLVKSLTHFEHLEEIKLGNNALGEptaleLAQRLPPQLRVLclpsshlgpegalg 1761
Cdd:COG5238 24 EELEMMDELVEVDLSGNTIGTEAMEELCNVIANVRNLRVVNFSDAFTGR-----DKDELYSNLVML-------------- 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 1762 lAQALEQCPHIEEVSLAENNLAggvPRFSKRLP--LLRQIDLEFCKIED------------QAARHLAANLTLF--PALE 1825
Cdd:COG5238 85 -LKALLKCPRLQKVDLSDNAFG---SEFPEELGdlISSSTDLVHLKLNNnglgpiaggrigKALFHLAYNKKAAdkPKLE 160
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 755526967 1826 KLLLSGNLLGDEVAAELAQVLPQMGQLKKVNLEWNRITARGAQLLA 1871
Cdd:COG5238 161 VVICGRNRLENGSKELSAALLESHENLKEVKIQQNGIRPEGVTMLA 206
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Signal ... |
1482-1700 |
6.37e-04 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Signal transduction mechanisms, RNA processing and modification];
Pssm-ID: 227563 [Multi-domain] Cd Length: 388 Bit Score: 44.15 E-value: 6.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 1482 KLLQNILLSSCELKSFRLTFSQVSTKSLTHLAFGLGHCHHLEELDFSNNSLREEDTELLMGALQGTCRLKKL-HLSFLP- 1559
Cdd:COG5238 82 VMLLKALLKCPRLQKVDLSDNAFGSEFPEELGDLISSSTDLVHLKLNNNGLGPIAGGRIGKALFHLAYNKKAaDKPKLEv 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 1560 -------LGASSLALLIQGLSRMTLLQDLCLSHNQIGDVGTQCLAAI-LPKLPELRKFDLSHNQIGDVGTQCLAAILPKL 1631
Cdd:COG5238 162 vicgrnrLENGSKELSAALLESHENLKEVKIQQNGIRPEGVTMLAFLgLFYSHSLEVLDLQDNTFTLEGSRYLADALCEW 241
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755526967 1632 PELRKFNLSHNQIGHVGTQCLAAILPKL--PELR--KFDLSRNQIGDVGTQCLAAILP-KLPELRKFDLSGNRI 1700
Cdd:COG5238 242 NLLRELRLNDCLLSNEGVKSVLRRFNEKfvPNLMplPGDYNERRGGIILDISLNEFEQdAVPLLVDLERNGNRI 315
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Signal ... |
1508-1716 |
1.20e-03 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Signal transduction mechanisms, RNA processing and modification];
Pssm-ID: 227563 [Multi-domain] Cd Length: 388 Bit Score: 43.38 E-value: 1.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 1508 SLTHLAFGLGHCHHLEELDFSNNSlreedtellmgalqgtcrlkklhlsflpLGASSLALLIQGLSRMTLLQDLCLSHNQ 1587
Cdd:COG5238 80 NLVMLLKALLKCPRLQKVDLSDNA----------------------------FGSEFPEELGDLISSSTDLVHLKLNNNG 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 1588 IGDVGTQCLAAILPKL---------PELRKFDLSHNQIGDVGTQCLAAILPKLPELRKFNLSHNQIGHVGTQCLAAI-LP 1657
Cdd:COG5238 132 LGPIAGGRIGKALFHLaynkkaadkPKLEVVICGRNRLENGSKELSAALLESHENLKEVKIQQNGIRPEGVTMLAFLgLF 211
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 755526967 1658 KLPELRKFDLSRNQIGDVGTQCLAAILPKLPELRKFDLSGNRIGPAGGVQLVKSLTHFE 1716
Cdd:COG5238 212 YSHSLEVLDLQDNTFTLEGSRYLADALCEWNLLRELRLNDCLLSNEGVKSVLRRFNEKF 270
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Signal ... |
861-1096 |
1.98e-03 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Signal transduction mechanisms, RNA processing and modification];
Pssm-ID: 227563 [Multi-domain] Cd Length: 388 Bit Score: 42.61 E-value: 1.98e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 861 AEALVELFQKSPQLEEVNLSG---NHLED---DGCRLVAEAASQLHIAQKLDLSDNGLSQTGVTYVLKAMSTCGTLEdlH 934
Cdd:COG5238 47 MEELCNVIANVRNLRVVNFSDaftGRDKDelySNLVMLLKALLKCPRLQKVDLSDNAFGSEFPEELGDLISSSTDLV--H 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 935 ISLLNNTV------VLTFAQEPREQEGSCKGRAPLISFV---------SPVTSELSQRSRR----IRLTHCGFLAKHTET 995
Cdd:COG5238 125 LKLNNNGLgpiaggRIGKALFHLAYNKKAADKPKLEVVIcgrnrlengSKELSAALLESHEnlkeVKIQQNGIRPEGVTM 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 996 LceALRASCQTHNLDHLDLSDNSLGGKGVILLTELLPGLGPLKSLNLSRNGLSMDAVFSLVQCLSSLQWVFHLDVSLESD 1075
Cdd:COG5238 205 L--AFLGLFYSHSLEVLDLQDNTFTLEGSRYLADALCEWNLLRELRLNDCLLSNEGVKSVLRRFNEKFVPNLMPLPGDYN 282
|
250 260
....*....|....*....|.
gi 755526967 1076 CIFLrgaGTSRDALEPKFQTG 1096
Cdd:COG5238 283 ERRG---GIILDISLNEFEQD 300
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
1578-1644 |
2.30e-03 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 37.89 E-value: 2.30e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755526967 1578 LQDLCLSHNQIGDVGTQCLAailpKLPELRKFDLSHNQIGDVGTQCLAailpKLPELRKFNLSHNQI 1644
Cdd:pfam13855 3 LRSLDLSNNRLTSLDDGAFK----GLSNLKVLDLSNNLLTTLSPGAFS----GLPSLRYLDLSGNRL 61
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
1766-1865 |
3.88e-03 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 40.92 E-value: 3.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 1766 LEQCPHIEEVSLAENNLAGGVP-RFSKR-----LPLLRQIDLEFCKIEDqaarhlAANLTLFPALEKLLLSGNLLGDevA 1839
Cdd:cd21340 86 LENLTNLEELHIENQRLPPGEKlTFDPRslaalSNSLRVLNISGNNIDS------LEPLAPLRNLEQLDASNNQISD--L 157
|
90 100
....*....|....*....|....*.
gi 755526967 1840 AELAQVLPQMGQLKKVNLEWNRITAR 1865
Cdd:cd21340 158 EELLDLLSSWPSLRELDLTGNPVCKK 183
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
710-787 |
4.21e-03 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 40.54 E-value: 4.21e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755526967 710 CRSLPTMG-SLKTLGLTGSRITAqgishlIQTLPLCSQLEEVSLHDNQLKDPEVLSlvELLPSLPKLQKLDLSRNSFSR 787
Cdd:cd21340 112 PRSLAALSnSLRVLNISGNNIDS------LEPLAPLRNLEQLDASNNQISDLEELL--DLLSSWPSLRELDLTGNPVCK 182
|
|
| LRR_4 |
pfam12799 |
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ... |
746-789 |
5.19e-03 |
|
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.
Pssm-ID: 432794 [Multi-domain] Cd Length: 44 Bit Score: 36.45 E-value: 5.19e-03
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 755526967 746 QLEEVSLHDNQLKDpevlslVELLPSLPKLQKLDLSRNSFSRSI 789
Cdd:pfam12799 2 NLEVLDLSNNQITD------LPPLAKLPNLETLDLSGNNKITDL 39
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
1630-1901 |
7.69e-03 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 41.37 E-value: 7.69e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 1630 KLPELRKFNLSHNQIGhvgTQCLAAILPKLPELRKFDLSRNQigdvgtqcLAAILPK--LPELRKFDLSGNRIGPaggvQ 1707
Cdd:PLN00113 91 RLPYIQTINLSNNQLS---GPIPDDIFTTSSSLRYLNLSNNN--------FTGSIPRgsIPNLETLDLSNNMLSG----E 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 1708 LVKSLTHFEHLEEIKLGNNALGEPTALELAQRlpPQLRVLCLPSSHLgpegALGLAQALEQCPHIEEVSLAENNLAGGVP 1787
Cdd:PLN00113 156 IPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNL--TSLEFLTLASNQL----VGQIPRELGQMKSLKWIYLGYNNLSGEIP 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755526967 1788 RFSKRLPLLRQIDLEFCKIEDQAARHLaANLT----LFPALEKL-------------LLSGNLLGDEVAAELAQVLPQMG 1850
Cdd:PLN00113 230 YEIGGLTSLNHLDLVYNNLTGPIPSSL-GNLKnlqyLFLYQNKLsgpippsifslqkLISLDLSDNSLSGEIPELVIQLQ 308
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 755526967 1851 QLKKVNLEWNRITARgaqlLAQGLVQGSCVPVIRLWNNPILNDVAQSLQSQ 1901
Cdd:PLN00113 309 NLEILHLFSNNFTGK----IPVALTSLPRLQVLQLWSNKFSGEIPKNLGKH 355
|
|
|