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Conserved domains on  [gi|755527082|ref|XP_011246763|]
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thymidine kinase 2, mitochondrial isoform X4 [Mus musculus]

Protein Classification

nucleoside/nucleotide kinase family protein( domain architecture ID 106737)

nucleoside/nucleotide kinase family protein may catalyze the reversible phosphate group transfer from nucleoside triphosphates to nucleosides/nucleotides, nucleoside monophosphates, or sugars

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NK super family cl17190
Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of ...
 26-136 1.11e-31

Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates to nucleosides/nucleotides, nucleoside monophosphates, or sugars. Members of this family play a wide variety of essential roles in nucleotide metabolism, the biosynthesis of coenzymes and aromatic compounds, as well as the metabolism of sugar and sulfate.


The actual alignment was detected with superfamily member pfam01712:

Pssm-ID: 450170  Cd Length: 201  Bit Score: 111.64  E-value: 1.11e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755527082   26 SGKMPEVDYAILSEWFDWIVRNIDvSVDLIVYLRTTPEICYQRLKMRCREEEKVIPMEYLHAIHRLYEEWLVNGSLFpaa 105
Cdd:pfam01712  95 KGTMSDEEYKTYKDLYDNMLLEFP-KPDLIIYLKTSPETCLERIKKRGRTEEQNISLDYLERLHEKYEAWLKKLNLS--- 170

                          90       100       110
                  ....*....|....*....|....*....|.
gi 755527082  106 aPVLVIEADhnlEKMLELFEQNRARILTPEN 136
Cdd:pfam01712 171 -PVLVIDGD---ELDFVFFEEDREDVMNEVN 197
 
Name Accession Description Interval E-value
dNK pfam01712
Deoxynucleoside kinase; This family consists of various deoxynucleoside kinases cytidine EC:2. ...
 26-136 1.11e-31

Deoxynucleoside kinase; This family consists of various deoxynucleoside kinases cytidine EC:2.7.1.74, guanosine EC:2.7.1.113, adenosine EC:2.7.1.76 and thymidine kinase EC:2.7.1.21 (which also phosphorylates deoxyuridine and deoxycytosine.) These enzymes catalyze the production of deoxynucleotide 5'-monophosphate from a deoxynucleoside. Using ATP and yielding ADP in the process.


Pssm-ID: 396326  Cd Length: 201  Bit Score: 111.64  E-value: 1.11e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755527082   26 SGKMPEVDYAILSEWFDWIVRNIDvSVDLIVYLRTTPEICYQRLKMRCREEEKVIPMEYLHAIHRLYEEWLVNGSLFpaa 105
Cdd:pfam01712  95 KGTMSDEEYKTYKDLYDNMLLEFP-KPDLIIYLKTSPETCLERIKKRGRTEEQNISLDYLERLHEKYEAWLKKLNLS--- 170

                          90       100       110
                  ....*....|....*....|....*....|.
gi 755527082  106 aPVLVIEADhnlEKMLELFEQNRARILTPEN 136
Cdd:pfam01712 171 -PVLVIDGD---ELDFVFFEEDREDVMNEVN 197
dNK cd01673
Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to ...
 26-115 2.57e-27

Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1.113), adenosine (EC 2.7.1.76), and thymidine (EC 2.7.1.21) kinases. They are key enzymes in the salvage of deoxyribonucleosides originating from extra- or intracellular breakdown of DNA.


Pssm-ID: 238836  Cd Length: 193  Bit Score: 99.99  E-value: 2.57e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755527082  26 SGKMPEVDYAILSEWFDWIVRNiDVSVDLIVYLRTTPEICYQRLKMRCREEEKVIPMEYLHAIHRLYEEWLVNGSLFpaA 105
Cdd:cd01673  100 EGGIMKTEYDLYNELFDNLIPE-LLPPDLVIYLDASPETCLKRIKKRGRPEEQGIPLDYLEDLHEAYEKWFLPQMYE--K 176

                         90
                 ....*....|
gi 755527082 106 APVLVIEADH 115
Cdd:cd01673  177 APVLIIDANE 186
Dck COG1428
Deoxyadenosine/deoxycytidine kinase [Nucleotide transport and metabolism];
24-126 7.93e-20

Deoxyadenosine/deoxycytidine kinase [Nucleotide transport and metabolism];


Pssm-ID: 441037 [Multi-domain]  Cd Length: 205  Bit Score: 80.99  E-value: 7.93e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755527082  24 ALSGKMPEVDYAILSEWFDWIVRNIdVSVDLIVYLRTTPEICYQRLKMRCREEEKVIPMEYLHAIHRLYEEWLVNgslFP 103
Cdd:COG1428   95 HEMGTLSDREFDLYRQLFDNLTEDL-PKPDLVIYLQASVDTLLERIKKRGRDYEQNIDLDYLERLNEAYEEWFEH---YD 170

                         90       100
                 ....*....|....*....|....*...
gi 755527082 104 aAAPVLVIEAD-----HNLEKMLELFEQ 126
Cdd:COG1428  171 -ASPVLIIDTDeldfvNNPEDLELLLEQ 197
 
Name Accession Description Interval E-value
dNK pfam01712
Deoxynucleoside kinase; This family consists of various deoxynucleoside kinases cytidine EC:2. ...
 26-136 1.11e-31

Deoxynucleoside kinase; This family consists of various deoxynucleoside kinases cytidine EC:2.7.1.74, guanosine EC:2.7.1.113, adenosine EC:2.7.1.76 and thymidine kinase EC:2.7.1.21 (which also phosphorylates deoxyuridine and deoxycytosine.) These enzymes catalyze the production of deoxynucleotide 5'-monophosphate from a deoxynucleoside. Using ATP and yielding ADP in the process.


Pssm-ID: 396326  Cd Length: 201  Bit Score: 111.64  E-value: 1.11e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755527082   26 SGKMPEVDYAILSEWFDWIVRNIDvSVDLIVYLRTTPEICYQRLKMRCREEEKVIPMEYLHAIHRLYEEWLVNGSLFpaa 105
Cdd:pfam01712  95 KGTMSDEEYKTYKDLYDNMLLEFP-KPDLIIYLKTSPETCLERIKKRGRTEEQNISLDYLERLHEKYEAWLKKLNLS--- 170

                          90       100       110
                  ....*....|....*....|....*....|.
gi 755527082  106 aPVLVIEADhnlEKMLELFEQNRARILTPEN 136
Cdd:pfam01712 171 -PVLVIDGD---ELDFVFFEEDREDVMNEVN 197
dNK cd01673
Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to ...
 26-115 2.57e-27

Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1.113), adenosine (EC 2.7.1.76), and thymidine (EC 2.7.1.21) kinases. They are key enzymes in the salvage of deoxyribonucleosides originating from extra- or intracellular breakdown of DNA.


Pssm-ID: 238836  Cd Length: 193  Bit Score: 99.99  E-value: 2.57e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755527082  26 SGKMPEVDYAILSEWFDWIVRNiDVSVDLIVYLRTTPEICYQRLKMRCREEEKVIPMEYLHAIHRLYEEWLVNGSLFpaA 105
Cdd:cd01673  100 EGGIMKTEYDLYNELFDNLIPE-LLPPDLVIYLDASPETCLKRIKKRGRPEEQGIPLDYLEDLHEAYEKWFLPQMYE--K 176

                         90
                 ....*....|
gi 755527082 106 APVLVIEADH 115
Cdd:cd01673  177 APVLIIDANE 186
Dck COG1428
Deoxyadenosine/deoxycytidine kinase [Nucleotide transport and metabolism];
24-126 7.93e-20

Deoxyadenosine/deoxycytidine kinase [Nucleotide transport and metabolism];


Pssm-ID: 441037 [Multi-domain]  Cd Length: 205  Bit Score: 80.99  E-value: 7.93e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755527082  24 ALSGKMPEVDYAILSEWFDWIVRNIdVSVDLIVYLRTTPEICYQRLKMRCREEEKVIPMEYLHAIHRLYEEWLVNgslFP 103
Cdd:COG1428   95 HEMGTLSDREFDLYRQLFDNLTEDL-PKPDLVIYLQASVDTLLERIKKRGRDYEQNIDLDYLERLNEAYEEWFEH---YD 170

                         90       100
                 ....*....|....*....|....*...
gi 755527082 104 aAAPVLVIEAD-----HNLEKMLELFEQ 126
Cdd:COG1428  171 -ASPVLIIDTDeldfvNNPEDLELLLEQ 197
NDUO42 cd02030
NADH:Ubiquinone oxioreductase, 42 kDa (NDUO42) is a family of proteins that are highly similar ...
 54-92 7.83e-03

NADH:Ubiquinone oxioreductase, 42 kDa (NDUO42) is a family of proteins that are highly similar to deoxyribonucleoside kinases (dNK). Members of this family have been identified as one of the subunits of NADH:Ubiquinone oxioreductase (complex I), a multi-protein complex located in the inner mitochondrial membrane. The main function of the complex is to transport electrons from NADH to ubiquinone, which is accompanied by the translocation of protons from the mitochondrial matrix to the inter membrane space.


Pssm-ID: 238988  Cd Length: 219  Bit Score: 35.02  E-value: 7.83e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 755527082  54 LIVYLRTTPEICYQRLKMRCREEEKVIPMEYLHAIHRLY 92
Cdd:cd02030  145 LVIYLDVPVPEVQKRIKKRGDPHEMKVTSAYLQDIENAY 183
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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