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Conserved domains on  [gi|755527276|ref|XP_011246811|]
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dysbindin domain-containing protein 1 isoform X1 [Mus musculus]

Protein Classification

Dysbindin domain-containing protein( domain architecture ID 10517140)

Dysbindin domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Dysbindin pfam04440
Dysbindin (Dystrobrevin binding protein 1); Dysbindin is an evolutionary conserved 40-kDa ...
 56-192 4.05e-51

Dysbindin (Dystrobrevin binding protein 1); Dysbindin is an evolutionary conserved 40-kDa coiled-coil-containing protein that binds to alpha- and beta-dystrobrevin in muscle and brain. Dystrophin and alpha-dystrobrevin are co-immunoprecipitated with dysbindin, indicating that dysbindin is DPC-associated in muscle. Dysbindin co-localizes with alpha-dystrobrevin at the sarcolemma and is up-regulated in dystrophin-deficient muscle. In the brain, dysbindin is found primarily in axon bundles and especially in certain axon terminals, notably mossy fibre synaptic terminals in the cerebellum and hippocampus. Dysbindin may have implications for the molecular pathology of Duchenne muscular dystrophy and may provide an alternative route for anchoring dystrobrevin and the DPC to the muscle membrane. Genetic variation in the human dysbindin gene is also thought to be associated with Schizophrenia.


:

Pssm-ID: 461312  Cd Length: 143  Bit Score: 161.57  E-value: 4.05e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755527276   56 VKVPQAALNVSAH-----ETGDMCRTPVAEEEEEVGIpipAPGFLQVTERRQPLSSVSSLEVHFDLLDLTELTDMSDQEL 130
Cdd:pfam04440   1 AEHAQKVLEMEHTqqlklKERQKFFEEAFQQDMEQYL---STGYLQITERRQPLGSVSSMEVNVDLLDQMELTDMSDQEA 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755527276  131 AEVFADSDDENLATESPAGlhpLSRASC-----LRSPSWTKTRAEQNREKQPPSDPER--QGTIVDTFL 192
Cdd:pfam04440  78 LDVFADSDGEENALESPAG---LPRSSCqneisLRVPSWTETRAEQPSESSPCTDPETenSDGGDDPLV 143
LGT super family cl00478
Prolipoprotein diacylglyceryl transferase;
4-93 8.26e-03

Prolipoprotein diacylglyceryl transferase;


The actual alignment was detected with superfamily member PRK13108:

Pssm-ID: 469786 [Multi-domain]  Cd Length: 460  Bit Score: 36.50  E-value: 8.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755527276   4 APHVAGAPQKPEVVMDRWTAASAQLSAQEPGKLAEVGGPQRATSLQKEIVKDVKVPQAALNVSAHETGDMCRTPVAEEEE 83
Cdd:PRK13108 288 SEYVVDEALEREPAELAAAAVASAASAVGPVGPGEPNQPDDVAEAVKAEVAEVTDEVAAESVVQVADRDGESTPAVEETS 367

                         90
                 ....*....|
gi 755527276  84 EVGIPIPAPG 93
Cdd:PRK13108 368 EADIEREQPG 377
 
Name Accession Description Interval E-value
Dysbindin pfam04440
Dysbindin (Dystrobrevin binding protein 1); Dysbindin is an evolutionary conserved 40-kDa ...
 56-192 4.05e-51

Dysbindin (Dystrobrevin binding protein 1); Dysbindin is an evolutionary conserved 40-kDa coiled-coil-containing protein that binds to alpha- and beta-dystrobrevin in muscle and brain. Dystrophin and alpha-dystrobrevin are co-immunoprecipitated with dysbindin, indicating that dysbindin is DPC-associated in muscle. Dysbindin co-localizes with alpha-dystrobrevin at the sarcolemma and is up-regulated in dystrophin-deficient muscle. In the brain, dysbindin is found primarily in axon bundles and especially in certain axon terminals, notably mossy fibre synaptic terminals in the cerebellum and hippocampus. Dysbindin may have implications for the molecular pathology of Duchenne muscular dystrophy and may provide an alternative route for anchoring dystrobrevin and the DPC to the muscle membrane. Genetic variation in the human dysbindin gene is also thought to be associated with Schizophrenia.


Pssm-ID: 461312  Cd Length: 143  Bit Score: 161.57  E-value: 4.05e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755527276   56 VKVPQAALNVSAH-----ETGDMCRTPVAEEEEEVGIpipAPGFLQVTERRQPLSSVSSLEVHFDLLDLTELTDMSDQEL 130
Cdd:pfam04440   1 AEHAQKVLEMEHTqqlklKERQKFFEEAFQQDMEQYL---STGYLQITERRQPLGSVSSMEVNVDLLDQMELTDMSDQEA 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755527276  131 AEVFADSDDENLATESPAGlhpLSRASC-----LRSPSWTKTRAEQNREKQPPSDPER--QGTIVDTFL 192
Cdd:pfam04440  78 LDVFADSDGEENALESPAG---LPRSSCqneisLRVPSWTETRAEQPSESSPCTDPETenSDGGDDPLV 143
PRK13108 PRK13108
prolipoprotein diacylglyceryl transferase; Reviewed
 4-93 8.26e-03

prolipoprotein diacylglyceryl transferase; Reviewed


Pssm-ID: 237284 [Multi-domain]  Cd Length: 460  Bit Score: 36.50  E-value: 8.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755527276   4 APHVAGAPQKPEVVMDRWTAASAQLSAQEPGKLAEVGGPQRATSLQKEIVKDVKVPQAALNVSAHETGDMCRTPVAEEEE 83
Cdd:PRK13108 288 SEYVVDEALEREPAELAAAAVASAASAVGPVGPGEPNQPDDVAEAVKAEVAEVTDEVAAESVVQVADRDGESTPAVEETS 367

                         90
                 ....*....|
gi 755527276  84 EVGIPIPAPG 93
Cdd:PRK13108 368 EADIEREQPG 377
 
Name Accession Description Interval E-value
Dysbindin pfam04440
Dysbindin (Dystrobrevin binding protein 1); Dysbindin is an evolutionary conserved 40-kDa ...
 56-192 4.05e-51

Dysbindin (Dystrobrevin binding protein 1); Dysbindin is an evolutionary conserved 40-kDa coiled-coil-containing protein that binds to alpha- and beta-dystrobrevin in muscle and brain. Dystrophin and alpha-dystrobrevin are co-immunoprecipitated with dysbindin, indicating that dysbindin is DPC-associated in muscle. Dysbindin co-localizes with alpha-dystrobrevin at the sarcolemma and is up-regulated in dystrophin-deficient muscle. In the brain, dysbindin is found primarily in axon bundles and especially in certain axon terminals, notably mossy fibre synaptic terminals in the cerebellum and hippocampus. Dysbindin may have implications for the molecular pathology of Duchenne muscular dystrophy and may provide an alternative route for anchoring dystrobrevin and the DPC to the muscle membrane. Genetic variation in the human dysbindin gene is also thought to be associated with Schizophrenia.


Pssm-ID: 461312  Cd Length: 143  Bit Score: 161.57  E-value: 4.05e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755527276   56 VKVPQAALNVSAH-----ETGDMCRTPVAEEEEEVGIpipAPGFLQVTERRQPLSSVSSLEVHFDLLDLTELTDMSDQEL 130
Cdd:pfam04440   1 AEHAQKVLEMEHTqqlklKERQKFFEEAFQQDMEQYL---STGYLQITERRQPLGSVSSMEVNVDLLDQMELTDMSDQEA 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755527276  131 AEVFADSDDENLATESPAGlhpLSRASC-----LRSPSWTKTRAEQNREKQPPSDPER--QGTIVDTFL 192
Cdd:pfam04440  78 LDVFADSDGEENALESPAG---LPRSSCqneisLRVPSWTETRAEQPSESSPCTDPETenSDGGDDPLV 143
PRK13108 PRK13108
prolipoprotein diacylglyceryl transferase; Reviewed
 4-93 8.26e-03

prolipoprotein diacylglyceryl transferase; Reviewed


Pssm-ID: 237284 [Multi-domain]  Cd Length: 460  Bit Score: 36.50  E-value: 8.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755527276   4 APHVAGAPQKPEVVMDRWTAASAQLSAQEPGKLAEVGGPQRATSLQKEIVKDVKVPQAALNVSAHETGDMCRTPVAEEEE 83
Cdd:PRK13108 288 SEYVVDEALEREPAELAAAAVASAASAVGPVGPGEPNQPDDVAEAVKAEVAEVTDEVAAESVVQVADRDGESTPAVEETS 367

                         90
                 ....*....|
gi 755527276  84 EVGIPIPAPG 93
Cdd:PRK13108 368 EADIEREQPG 377
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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