|
Name |
Accession |
Description |
Interval |
E-value |
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
1-418 |
1.32e-180 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 514.04 E-value: 1.32e-180
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 1 MMFLISFISSVFCGHLGKLELDAVTLAIAVINVTGISVGHGLSSACDTLISQTYGSQNLKHVGVILQRGTLILLLCCFPC 80
Cdd:cd13132 18 LQYSLSVVSVVFVGHLGKLELAAASLASSFANVTGFSILLGLASALDTLCGQAFGAKNYKLVGVYLQRALVILLLCCVPI 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 81 WALFINTEQILLLFRQDPDVSRLTQTYVMIFIPALPAAFLYTLQVKYLLNQGIVLPQIMTGIAANLVNALANYVFLYHLH 160
Cdd:cd13132 98 SLLWLNTEPILLLLGQDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVYISLVALLLNILLNYLLVFVLG 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 161 LGVMGSALANTISQFALAIFLFLYILWRRLHQATWGGWSWECLQDWASFLRLAIPSMLMLCIEWWAYEVGSFLSGIL-GM 239
Cdd:cd13132 178 LGFIGAALATSISYWLIVVLLLLYIFFSKGHKATWGGFSREAFRGWGPFLKLAIPSALMLCLEWWAFEILVLLAGLLpGT 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 240 VELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKKSSAISLIVTELFAVTFCVLLLGCKDLVGYIFTTDR 319
Cdd:cd13132 258 VALAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNPKRAKLAAIVALILSLVIGVVVAILLLVLRDVWAYLFTSDE 337
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 320 DIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQKVGAIVNAIGYYVIGLPIGIALMFAAKLGVIGLWSGIIICTTCQ 399
Cdd:cd13132 338 EVIALVADLLPILALFQIFDGLQAVLSGVLRGCGRQKLGAYVNLVAYYLIGLPVGLLLAFVLGLGLKGLWIGLIAGLILQ 417
|
410
....*....|....*....
gi 755539399 400 TTCFLAFIARLNWKRACQQ 418
Cdd:cd13132 418 AVILLLIILRTDWDKEAEK 436
|
|
| MATE_NorM_like |
cd13131 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ... |
3-413 |
2.34e-66 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.
Pssm-ID: 240536 [Multi-domain] Cd Length: 435 Bit Score: 220.83 E-value: 2.34e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 3 FLISFISSVFCGHLGKLELDAVTLAIAVINVTgISVGHGLSSACDTLISQTYGSQNLKHVGVILQRGTLILLLCCFPCWA 82
Cdd:cd13131 20 MAMGFVDTVMAGRLGADDLAAVALGSSLWFPV-FTFGMGLLLAVTPLVAQAHGAGDRRRIRRAVRQGLWLALLLSLPLML 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 83 LFINTEQILLLFRQDPDVSRLTQTYVMIFIPALPAAFLYTLQVKYLLNQGIVLPQIMTGIAANLVNALANYVFLY-HLH- 160
Cdd:cd13131 99 LLWLAPPILPLMGQEPEVAAIARGYLLALAWGIPPALLFQVLRSFLDALGRTRPAMVITLLALVLNIPLNYVLIFgKFGl 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 161 --LGVMGSALANTISQFALAIFLFLYILWRRL--HQATWGGWSWECLQDWASFLRLAIPSMLMLCIEWWAYEVGSFLSGI 236
Cdd:cd13131 179 paLGGAGAGLATAIVYWLMFLALAFYIRRHKRfrRYRLFARFWRPDWARLKELLRLGLPIGLTIFFEVSLFAAVALLMGR 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 237 LGMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKKSSAISLIVTELFAVTFCVLLLGCKDLVGYIFT 316
Cdd:cd13131 259 LGTTVLAAHQIALNFASLLFMVPLGISMAATVRVGFALGAGDPADARRAGLVGLGLGVGFAALTALLLLLFPEQIAGLYT 338
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 317 TDRDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQKVGAIVNAIGYYVIGLPIGIALMFAAKLGVIGLWSGIIICT 396
Cdd:cd13131 339 NDPAVIALAASLLVFAALFQLFDGIQVVAAGALRGYKDTRVPFLLALISYWGIGLPLGYLLAFTTGLGAFGVWIGLIIGL 418
|
410
....*....|....*..
gi 755539399 397 TCQTTCFLAFIARLNWK 413
Cdd:cd13131 419 ALAAILLLWRFRRLQRR 435
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
1-406 |
5.10e-65 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 216.93 E-value: 5.10e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 1 MMFLISFISSVFCGHLGKLELDAVTLAIAVINVTgISVGHGLSSACDTLISQTYGSQNLKHVGVILQRGTLILLLCCFPC 80
Cdd:COG0534 23 LQSLYGLVDTIFVGRLGTAALAAVGLAFPIFFLL-IALGIGLGVGGTALVAQALGAGDREEARRVLGQALLLALLLGLLL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 81 WAL-FINTEQILLLFRQDPDVSRLTQTYVMIFIPALPAAFLYTLQVKYLLNQGIVLPQIMTGIAANLVNALANYVFLYHL 159
Cdd:COG0534 102 TLLgLLFAPPLLRLLGADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPMIIMLIGNVLNIVLDPLLIFGG 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 160 HLGVMGSALANTISQFALAIFLFLYILWRRLHQATWGGWSWECLQDWASFLRLAIPSMLMLCIEWWAYEVGSFLSGILGM 239
Cdd:COG0534 182 GLGVAGAALATVISQAVSALLLLYYLFRKRSLLRLRLRDLRPDRKILKRILRIGLPAGLQQLAESLGFLVLNALVARLGT 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 240 VELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKKSSAISLIVTELFAVTFCVLLLGCKDLVGYIFTTDR 319
Cdd:COG0534 262 AAVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALLLALGIGLLLALLLFLFPEPIIGLFTDDP 341
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 320 DIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQKVGAIVNAIGYYVIGLPIGIALMFaAKLGVIGLWSGIIICTTCQ 399
Cdd:COG0534 342 EVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWLVRLPLAYLLAF-LGLGLTGVWLALPIGEVLR 420
|
....*..
gi 755539399 400 TTCFLAF 406
Cdd:COG0534 421 ALLLLLR 427
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
3-333 |
6.39e-58 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 195.54 E-value: 6.39e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 3 FLISFISSVFCGHLGKLELDAVTLAiAVINVTGISVGHGLSSACDTLISQTYGSQNLKHVGVILQRGTLILLLCCFPCWA 82
Cdd:TIGR00797 10 PLLGLVDTAFVGHLGPVDLAAVSLG-SSVFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLALLLGLPVLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 83 LFINTEQILLLFRQ-DPDVSRLTQTYVMIFIPALPAAFLYTLQVKYLLNQGIVLPQIMTGIAANLVNALANYVFLYHLH- 160
Cdd:TIGR00797 89 VGYFFIDPLLSLMGaDGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIILNYILIFGKFg 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 161 -LGVMGSALANTISQFALAIFLFLYILWRRLHQATWGGWSWECLQDWASFLRLAIPSMLMLCIEWWAYEVGSFLSGILGM 239
Cdd:TIGR00797 169 fLGIVGAALATVISYWLMFLLLLYYIKKAKKIGLKWEGLLKPDWEVLKRLLKLGLPIAFRVILESLSFALLALLVARLGS 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 240 VELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKKSSAISLIVTELFAVTFCVLLLGCKDLVGYIFTTDR 319
Cdd:TIGR00797 249 IALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVARVALKLSLLLGLVLAIILILFREFIARLFTNDP 328
|
330
....*....|....
gi 755539399 320 DIVALVAQVIPIYA 333
Cdd:TIGR00797 329 EVLELAAIYLIFVA 342
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
1-407 |
4.97e-49 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 174.43 E-value: 4.97e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 1 MMFLISFISSVFCGHLGKLELDAVTLAIAVINvTGISVGHGLSSACDTLISQTYGSQNLKHVGVILQRGTLILLLCCFPC 80
Cdd:cd12082 10 LQTLYNLVDTFFLGRLLGDALAAVGLAFPLIA-LLIALGVGLSVGTSALISQAIGAGDEEKARRVLVQSIVLAILLGLLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 81 WAL-FINTEQILLLFRQDPDVSRLTQTYVMIFIPALPAAFLYTLQVKYLLNQGIVLPQIMTGIAANLVNALANYVFLY-- 157
Cdd:cd12082 89 AALlLFFSPLILSLLGAEEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLLNILLDPLLIFgl 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 158 -HLHLGVMGSALANTISQFALAIFLFLYILWRRLHQATWGGWSWECLQDWASFLRLAIPSMLMLCIEWWAYEVGSFL-SG 235
Cdd:cd12082 169 gPPELGIAGAALATVISYVIGALLLLIYLRKGKKILKFKLSLLKPDLELLRRLLRIGLPSAIQNSLLSLGLLIIVAIvAA 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 236 ILGMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKKSSAISLIVTELFAVTFCVLLLGCKDLVGYIF 315
Cdd:cd12082 249 FGGAAALAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRARRITWVALLIGLLIGAVLGLLILLFPEPILSLF 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 316 TTDRDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQKVGAIVNAIGYYVIGLPIGIALMFAAkLGVIGLWSGIIIC 395
Cdd:cd12082 329 TNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLSYWVVRLPLAYVLAYLG-LGLYGIWLALVIS 407
|
410
....*....|..
gi 755539399 396 TTCQTTCFLAFI 407
Cdd:cd12082 408 LILAALVLLLFF 419
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
4-412 |
5.06e-47 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 169.24 E-value: 5.06e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 4 LISFISSVFCGHLGKLELDAVTLAiAVINVTGISVGHGLSSACDTLISQTYGSQNLKHVGVILQRGTLILLLCCFPCWAL 83
Cdd:cd13133 23 VMGFTDRAFLGRLSEVALAASGPA-GVLYFAILMLFFGLSSGVQVFVAQYNGAGRYSRIGRVLWQGLYFSLLLAPLLALL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 84 FI-NTEQILLLFRQDPDVSRLTQTYVMIFIPALPAAFLYTLQVKYLLNQGIVLPQIMTGIAANLVNALANYVFLY-HL-- 159
Cdd:cd13133 102 SAlAAPLLFLLLGHSPEVQALEVEYFRIRILGAPFSLLGAALRAFFSGIGRTRVVMVANLVMVVVNIVLDYALIFgKLgf 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 160 -HLGVMGSALANTISQFALAIFLFLYILWRRLHQ--ATWGGWSWEcLQDWASFLRLAIPSMLMLCIEWWAYEVGSFLSGI 236
Cdd:cd13133 182 pAMGIAGAAIATVIAEAVSLLFFLLLLFRRKNRRrfGLRRAWRFD-RELLRRILRLGLPSGLQFFLDVGAFTVFFLLIGR 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 237 LGMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKKSSAISLIVTELFAVTFCVLLLGCKDLVGYIFT 316
Cdd:cd13133 261 LGTTELAATNIVFSINSLAFLPMIGLGIAVSSLVGQALGAGRPDLAMRVTRRGLKLALAYMLLLGILFLLFPELLLSIFT 340
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 317 TDRDIVALVAQVIPIY---AVSHLFEGLACTCGGILRGTGNQKVGAIVNAIGYYVIGLPIGIALMFaAKLGVIGLWSGII 393
Cdd:cd13133 341 PGADFALIAELAVPLLrfvAAYILFDALALVFAGALRGAGDTRFVMLAELIVAWLYLLPPAYLLVV-LGAGLAGAWTVET 419
|
410
....*....|....*....
gi 755539399 394 ICTTCQTTCFLAFIARLNW 412
Cdd:cd13133 420 VYVIVLALIFLLRFRSGKW 438
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
3-413 |
1.30e-46 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 168.07 E-value: 1.30e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 3 FLISFISSVFCGHLGKLELDAVTLAIAVINVTgISVGHGLSSACDTLISQTYGSQNLKHVGVILQRGTLILLLCCFP-CW 81
Cdd:cd13137 18 TLVGLVDVFMVGRLGAEAIAAVGLATQVLWLL-LVLNMALGTGTVALVSQSYGAGDYERARRALGQSLLLALLLSLPlAL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 82 ALFINTEQILLLFRQDPDVSRLTQTYVMIFIPALPAAFLYTLQVKYLLNQGIVLPQIMTGIAANLVNALANYVFLYHLH- 160
Cdd:cd13137 97 LGLLFAEPLLRLLGADPEVIALALTYLRIVLLGIPFFFLSLVGNAALRGAGDTKTPMYIMIIVNVLNIVLDYVLIFGLWg 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 161 ---LGVMGSALANTISQFALAIFLFLYILWRRLH-QATWGGWSWEcLQDWASFLRLAIPSMLMLCIEWWAYEVGSFLSGI 236
Cdd:cd13137 177 fpgLGVAGAALATVISRVVGALLLLFLLLRGRLPiKISFKGFRLD-RKIIKKLLRIGLPAGLEQLLRSLGFLVLLAIVAS 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 237 LGMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKKSSAISLIVTELFAVTFCVLLLGCKDLVGYIFT 316
Cdd:cd13137 256 YGTAALAAYQIGLRIESLAFMPGFGFSMAASTLVGQNLGAGDPDEARRYGKRALRLGVLFMGLLGLLLFIFAPPLASLFT 335
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 317 TDRDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQKVGAIVNAIGYYVIGLPIGIALMFAAKLGVIGLWSGIIICT 396
Cdd:cd13137 336 PDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPPLIINLISMWLVRLPLAYLLGFVLGLGLTGIWLAMFVDT 415
|
410
....*....|....*..
gi 755539399 397 TCQTTCFLAFIARLNWK 413
Cdd:cd13137 416 IVRAILLLYRFRKGKWK 432
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
1-414 |
4.75e-36 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 139.17 E-value: 4.75e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 1 MMFLISFISSVFCGHLGKLELDAVTLAIAVINVtGISVGHGLSSACDTLISQTYGSQNLKHVGVILQRGTLI-LLLCCFP 79
Cdd:cd13134 18 LQMLLGTIDTFMLSRYSDNAVAAVGVANQILFL-LILIFSFISTGTSILIAQYLGAKDKKKARQIAGVALLFnLLLGLVF 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 80 CWALFINTEQILLLFRQDPDVSRLTQTYVMIFIPALpaaFLYTLQVKY---LLNQGIVLPQIMTGIAANLVNALANYVFL 156
Cdd:cd13134 97 SLLLLFFGAELLRLMGLPPELLALGSTYLRIVGGSL---FLQALSLTLsaiLRSHGRTKIPMYVSLIMNILNIVGNYLLI 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 157 Y----HLHLGVMGSALANTISQFA---LAIFLFLYILWRRLHQATWGGWSWECLQDwasFLRLAIPSMLMLCIEWWAYEV 229
Cdd:cd13134 174 FgwfgLPKLGVAGVAISTVISRAVglvLLFILLFRKLKIRFRLKDLRPFPKKLLKK---ILKIGLPSAGEELSYNLSQTV 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 230 GSFLSGILGMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKKSSAISLIVTELFAVTFCVLLLGCKD 309
Cdd:cd13134 251 ITAFIARLGTAALAARTYASNISMFVFLFSLAIGQATQIIVGHLVGAGDFDEAYKRVLKSLKIGLLVSLAVALLLALFRE 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 310 LVGYIFTTDRDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQKVGAIVNAIGYYVIGLPIGIALMFAAKLGVIGLW 389
Cdd:cd13134 331 PILGLFTDDPEIIALGKTLLLISILLEPGRAFNIVLIGSLRAAGDARFPVLIGIISMWGISVPLAYLLGIVLGLGLLGVW 410
|
410 420
....*....|....*....|....*
gi 755539399 390 SGIIICttcqtTCFLAFIARLNWKR 414
Cdd:cd13134 411 IAFAAD-----EWVRGIIMLWRWRS 430
|
|
| PRK01766 |
PRK01766 |
multidrug efflux protein; Reviewed |
3-394 |
1.41e-35 |
|
multidrug efflux protein; Reviewed
Pssm-ID: 234981 [Multi-domain] Cd Length: 456 Bit Score: 138.02 E-value: 1.41e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 3 FLISFISSVFCGHLGKLELDAVTLAiAVINVTGISVGHGLSSACDTLISQTYGSQNLKHVGVILQRGTLILLLCCFPCWA 82
Cdd:PRK01766 29 TAMGFVDTVMAGGVSATDLAAVAIG-TSIWLPVILFGHGLLLALTPIVAQLNGAGRRERIAHQVRQGLWLALFLSVLIML 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 83 LFINTEQILLLFRQ-DPDVSRLTQTYVMIFIPALPAAFLYtlQVKYLLNQGI--VLPQIMTGIAANLVNALANYVFLYHL 159
Cdd:PRK01766 108 VLYNAVPPILNMMNlEPEVADIAVGYLHALLWGIPAYLLY--QVLRSFIDGLgkTKPTMVIGFLGLLINIPLNYIFIYGK 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 160 ----HLGVMGSALANTISQFALAIFLFLYILWRRL--HQATWGGWSWECLQDWASFLRLAIPSMLMLCIEWWAYEVGSFL 233
Cdd:PRK01766 186 fgfpELGGVGCGVATAIVYWVMFLAMLIYIKRARRfrDFRLFKGLYKPDWAVIKRLLKLGLPIGLAIFFEVSLFAVVTLL 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 234 SGILGMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKKSSAISLIVTELFAVTFCVLLLGCKDLVGY 313
Cdd:PRK01766 266 VSPLGTVTVAAHQIALNFSSLLFMLPLSLAMALTIRVGFELGAGRTLDARQYAYIGLAVGLGMALLTAIFLVLFREQIAL 345
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 314 IFTTDRDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQKVGAIVNAIGYYVIGLPIGIALMFAAKLGVIGLWSGII 393
Cdd:PRK01766 346 LYTDDPEVVALASHLLLFAALFQFSDAIQVIGSGALRGYKDTRVIFFITFIAYWVLGLPLGYILALTDPMGPFGFWIGLI 425
|
.
gi 755539399 394 I 394
Cdd:PRK01766 426 I 426
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
4-413 |
9.64e-33 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 129.50 E-value: 9.64e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 4 LISFISSVFCGH-LGKLELDAVTLAIAVINVTgISVGHGLSSACDTLISQTYGSQNLKHVG-VILQRGTLILLLCCFPCW 81
Cdd:cd13138 21 LYNLVDLLIVGQfLGVAALAAVSNGSPIIFLL-TAIGMGLSMGGTILISQYIGAKDEEKAKkAVGTLLVLFLILGIVLTI 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 82 ALFINTEQILLLFRQDPDVSRLTQTYVMIFIPALPAAFLYTLqVKYLLNqGI---VLPQIMTGIAAnLVNALANYVFLYH 158
Cdd:cd13138 100 LGLLFAPPILRLMNTPAEILELAVSYLRICFLGIPFIFGYNA-YSAILR-GLgdsKTPLYFVIIAC-VLNIILDLLFIAV 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 159 LHLGVMGSALANTISQFALAIFLFLYILWRRLH-QATWGGWSWEcLQDWASFLRLAIPSMLMLCIewwayevgSFLSGIL 237
Cdd:cd13138 177 FHMGVAGAALATVIAQAISVLLALYYLRKKKLPfKLSLKDFRFD-KEILKEILKIGLPSALQQSL--------VSISFLI 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 238 --------GMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKKSSAISLIVTELFAVTFCVLLLGCKD 309
Cdd:cd13138 248 insivnsyGVVASAAYGIANKINSFAFLPPSAIGQAVSTFVAQNIGAGKIERAKKGLRTGIIISLIIGLIIILLVFFFAP 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 310 LVGYIFTTDRDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQKVGAIVNAIGYYVIGLPIGIALMFAAKLGVIGLW 389
Cdd:cd13138 328 QLLGLFTSDPEVIEIGAEYLRIYSIDYILFGILFVFNGLFRGLGKTKFPMIISILRLWLVRIPLAYLLSRLTGLGLFGIW 407
|
410 420
....*....|....*....|....
gi 755539399 390 SGIIICTTCQTTCFLAFIARLNWK 413
Cdd:cd13138 408 LAMPISNILSAIICIIYYRKGRWK 431
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
1-389 |
1.95e-29 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 120.31 E-value: 1.95e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 1 MMFLISFISSVFCGHL-GKLELDAVTLAIAVIN-VTGISVGHGLSSAcdTLISQTYGSQNLKHVGVILQRG-TLILLLCC 77
Cdd:cd13143 19 VNGLYNIVDGIFVGHGvGALALAAVNLVFPIIMlLMALGLMIGVGGA--SLISRRLGAGDREKANRIFSTAlLLSLILGL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 78 FPCWALFINTEQILLLFRQDPDVSRLTQTYVMIFIPALPAAFLYTLQVKYLLNQGIVLPQIMTGIAANLVNALANYVFLY 157
Cdd:cd13143 97 LLTILGLLFLDPLLRLLGASGELLPYAVDYLRIILLGAPFTILSSVLNNLLRAEGKPKLAMLGMLIGAVLNIILDPLFIF 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 158 HLHLGVMGSALANTISQFALAIFLFLYILWRR-LHQATWGGWSWEcLQDWASFLRLAIPSMLMlciewwayEVGSFLSGI 236
Cdd:cd13143 177 VLGLGIAGAALATVIAQLISLLLLLLYFFRGKsLLKLSLLRFKLS-LKIIKEILALGFPSFLM--------QLSSSVVTI 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 237 L---------GMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKKSSAISLIVTELFAVTFCVLLLGC 307
Cdd:cd13143 248 VlnltllgygGDIGVAAFGIVTRILTFLFLPLIGLSQGLQPIIGYNYGAGNYDRVKQALKLALIVALIYGLVLFLILLLF 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 308 KDLVGYIFTTDRDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQKVGAIVNAIGYYVigLPIGIALMFAAKLGVIG 387
Cdd:cd13143 328 PEQIVSLFTDDPELIALAARILRIFLLAFPLAGINIVLSGYFQAIGKAKRAALLSLLRQGL--FLIPLLLILPRLFGLDG 405
|
..
gi 755539399 388 LW 389
Cdd:cd13143 406 IW 407
|
|
| MATE_like_12 |
cd13142 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
14-414 |
3.50e-28 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240547 [Multi-domain] Cd Length: 444 Bit Score: 116.91 E-value: 3.50e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 14 GHLGKLELDAVTLAIAVInVTGISVGHGLSSACDTLISQTYGSQNLKHVGVIL-QRGTLILLLCCFPCWALFINTEQILL 92
Cdd:cd13142 39 GRLGADAVAAPSISWPLI-FLFISLGGGLTVAGTALVAQYTGAGDYDKANKVAgQTFSFVIILSLILAVLGYILSRPLLL 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 93 LF-RQDPDVSRLTQTYVMIFIPALPAAFLY-TLQVkylLNQGI---VLPQIMTGIAAnLVNALANYVFLYHL----HLGV 163
Cdd:cd13142 118 LLiGAPEEVYPLALAYLRIIFLGLPFMFIFfVFNS---LLRGIgdtKTPMKIMFGSV-LLNVILDPLLIFGIgpfpGLGV 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 164 MGSALANTISQFALAIFLfLYILWRRLH------QATWGGWSWeclqdWASFLRLAIPSMLMLCIEWWAYEVGSFLSGIL 237
Cdd:cd13142 194 AGAALATVISRGIAAVIG-LYLLFKGRVglkislRDLKPDWEW-----LKKIFRIGLPSSIEQSARALGFTVMTALVAGF 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 238 GMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKKSSAISLIVTELFAVTFCVLLLGCKDLVGYIFTT 317
Cdd:cd13142 268 GTVVVAAYGIGNRIISLVFLPAFGLARATSTMVGQNLGAGQIDRAEEIVKKAALLIFLILVIGGVLAFLFAEPIVRVFIN 347
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 318 DRDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQKVGAIVNAIGYYVIGLPIGIALMFAAKLGVIGLWSGIIICTT 397
Cdd:cd13142 348 DPEVIKEGADFLRIVAPSFPFFGLFQVINGAFRGSGHTLTAMIISILRLWVIRIPLAYLLAYVLGLGVTGIWIAMAISNI 427
|
410
....*....|....*..
gi 755539399 398 CQTTCFLAFIARLNWKR 414
Cdd:cd13142 428 VAALIALAWFKRGTWKK 444
|
|
| MATE_DinF_like |
cd13136 |
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ... |
14-394 |
1.30e-27 |
|
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240541 [Multi-domain] Cd Length: 424 Bit Score: 114.97 E-value: 1.30e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 14 GHLGKL-ELDAVTLAIAVINVtgISVGHG-LSSACDTLISQTYGSQNLKHVGVILQRGTLILLLCcfpcwALFINTEQ-- 89
Cdd:cd13136 31 GHLGSAaYLGAVALGTTIFNT--LFWLFGfLRMGTTGLVAQALGAGDREEAIALLVRALLLALAI-----GLLLILLQsp 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 90 ----ILLLFRQDPDVSRLTQTYVMIFIPALPAAFL-YTLQVKYLLNQGIVLPQIMTgIAANLVNALANYVFLYHLHLGVM 164
Cdd:cd13136 104 llalALLLLGASAAVAALARQYLRIRILGAPAVLLnYVATGWFRGLQDTRTPLILQ-IVGNVVNIVLDPLFVFGLGWGVA 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 165 GSALANTISQFALAIfLFLYILWRRLHQATWGGWSweCLQDWASFLRLAIPS------MLMLCIewwAYEVGSFLSGILG 238
Cdd:cd13136 183 GAALATVIAQYLGAL-LGLWLLRRRVRLLGKSLSR--RLPSKAALKRLFKLNrdifirTLALLA---AFLFFTALAARLG 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 239 MVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKKSSAISLIVTELFAVTFCVLLLGCKDLVGYIFTTD 318
Cdd:cd13136 257 DVILAANQILLQFWLLSSYFLDGFAYAAEALVGRALGAGDRKAARRVARRLLQWGLGLGVLLALLFFLGGEPIIRLFTDD 336
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755539399 319 RDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGnqKVGAIVNAIgyyVIGLPIGIALMFAAK--LGVIGLWSGIII 394
Cdd:cd13136 337 PAVLALAATYLPWLALLPPIGALAFVLDGIFIGAT--DTRYLRNSM---LVSLAVFLPLLFLLVplWGNHGLWLALIL 409
|
|
| PRK00187 |
PRK00187 |
NorM family multidrug efflux MATE transporter; |
41-431 |
9.33e-24 |
|
NorM family multidrug efflux MATE transporter;
Pssm-ID: 166843 [Multi-domain] Cd Length: 464 Bit Score: 104.06 E-value: 9.33e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 41 GLSSACDTLISQTYGSQNLKHVGVILQRGTLILLLCCFPCWALFINTEQILLLFRQDPDVSRLTQTYVMIFIPALPAAFL 120
Cdd:PRK00187 64 GVIAAVGTLVAIRHGAGDIEGATRLAQAGLWLAWLLALVAALLLWNLKPLLLLFGQAPQNVDAAMQFLHLLPFALPGYLS 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 121 YTLQVKYLLNQGIVLPQIMTGIAANLVNALANYVFLYHL----HLGVMGSALANTISQFALAIFLFLYILWRRLHQA--T 194
Cdd:PRK00187 144 FMALRGFTSALGRAGPVMVISLAGAVANLLLNYALIEGWfglpKLGLMGIGLVTALVSNGMALALALYIRRHPAYAAypL 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 195 WGGWSWECLQDWASFLRLAIPSMLMLCIEWWAYEVGSFLSGILGMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNAL 274
Cdd:PRK00187 224 RKGLSRPSRAALRELWRLGLPIGGTYAVEVGLFTFAALCMGALGSTQLAAHQIALQIVSVAFMVPVGLSYAVTMRVGQHY 303
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 275 GAGNIDQAKKSSAISL----IVTELFAVTFcvlLLGCKDLVGYIFTTD----RDIVALVAQVIPIYAVSHLFEGLACTCG 346
Cdd:PRK00187 304 GAGRLLEARRAGRVGIgfgaVVMLLFAGLF---WLLPEAIIGLFLDRNdpafAEIVQLAVSLLAVAAWFELFDGTQTIAM 380
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 347 GILRGTGNQKVGAIVNAIGYYVIGLPIGIALMFAAKLGVIGLWSGIIICTTCQTtcfLAFIARLNWKRACQQAQVHANLK 426
Cdd:PRK00187 381 GAIRGLKDARTTFLIGLACYWLVGAPLAWLLAFTLGWGAVGVWWGLALGLACAA---VALTLAFEWKTARLLRKARASEA 457
|
....*
gi 755539399 427 VNVAL 431
Cdd:PRK00187 458 VALSA 462
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
215-374 |
1.44e-23 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 96.87 E-value: 1.44e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 215 PSMLMLCIEWWAYEVGSFLSGILGMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKKSSAISLIVTE 294
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 295 LFAVTFCVLLLGCKDLVGYIFTTDRDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQKVGAIVNAIGyYVIGLPIG 374
Cdd:pfam01554 81 LLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIIS-LLLNIPLN 159
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
1-154 |
1.06e-21 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 91.86 E-value: 1.06e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 1 MMFLISFISSVFCGHLGKLELDAVTLAIAVINVTgISVGHGLSSACDTLISQTYGSQNLKHVGVILQRGTLILLLCCFP- 79
Cdd:pfam01554 8 LQSLYSLIDTLFVGHLGAVALAAVSIANSIASLI-FMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILGLLLSLPi 86
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755539399 80 CWALFINTEQILLLFRQDPDVSRLTQTYVMIFIPALPAAFLYTLQVKYLLNQGIVLPQIMTGIAANLVNALANYV 154
Cdd:pfam01554 87 ALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIPLNYL 161
|
|
| MATE_like_1 |
cd13140 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
27-413 |
1.08e-21 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240545 [Multi-domain] Cd Length: 435 Bit Score: 97.60 E-value: 1.08e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 27 AIAVINVTGISVGhglssacdtlISQTYGSQNLKHVGVILQRGTLI-LLLCCFPCWALFINTEQILLLFR-QDPDVSRLT 104
Cdd:cd13140 55 ALALLSKIGAQVK----------VSQSIGAKDEKEARKYARNALQLnLLLGILYGLLLLLFAKPLIGFFNlGDAEVISLA 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 105 QTYVMIFIPALPAAFLYTLQVKYLLNQG-IVLPQIMTGIAaNLVNALANYVFLYHL----HLGVMGSALANTISQfALAI 179
Cdd:cd13140 125 ITYLRIVALGLIFSFLNPVFTGIFNALGdSKTPFIINAIG-LVLNIILDPLLIFGFgpfpALGVAGAALATVLAQ-AIVF 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 180 FLFLYILwRRLHQATWGGWSWECL--QDWASFLRLAIP----SMLMLCIEWWayeVGSFLSGiLGMVELGAQSITYELAI 253
Cdd:cd13140 203 LLFLYAL-KKKKGLFLKIRILKRPdrKYIKEILKLGLPvalqSILFALISMI---LARIIAS-FGPVAIAAQKVGSQIES 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 254 IVYMIPSGFSVAANVRVGNALGAGNIDQAKKSSAISLIVTELFAVTFCVLLLGCKDLVGYIFTTDRDIVALVAQVIPIYA 333
Cdd:cd13140 278 ISWMTAEGFSTALAAFVGQNYGAGKYDRIRKGYKTALKIASAIGLFATLLLFFFGEPLFSLFIPDPETIAIGVDYLRILG 357
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 334 VSHLFEGLACTCGGILRGTGNQKVGAIVnAIGYYVIGLPIGIALMFAAkLGVIGLWSGIIICTTCQTTCFLAFIARLNWK 413
Cdd:cd13140 358 FSQLFMCLEITTTGAFNGLGRTKPPAII-SIVFNGLRIPLALLLSPTG-LGLNGIWWAISISSILKGIILTIWFLLYKKK 435
|
|
| MATE_like_14 |
cd13139 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
12-414 |
8.49e-18 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240544 [Multi-domain] Cd Length: 448 Bit Score: 85.74 E-value: 8.49e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 12 FCGHLGKLELDAVTLAIAVINVTgISVGHGLSSACDTLISQTYGSQNLKHVGVILQRGTLILLLCCFPCWAL-FINTEQI 90
Cdd:cd13139 40 FVSRLGALAIATVGLTESVLTIV-YSIAIGLSMAATALVARRIGEKDPEGAGFAAVQAILLGVALSLILSILgYFFAEDI 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 91 LLLFRQDPDVSRLTQTYVMIFIPALPAAFLYtlqvkyLLNQGIVLPQIMTGIA------ANLVNALANYVFLYHL----H 160
Cdd:cd13139 119 LSLMGASPAVIAEGYGYTRIMFGGNGFIMLL------FLINGIFRGAGDAAIAmrslwlANGLNIILDPLFIFGLgpipA 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 161 LGVMGSALANTISQFALAIFLFLYILW-------RRLHQAtwggWSWECLQdwaSFLRLAIPSMLMLCIEwwayeVGSFL 233
Cdd:cd13139 193 MGVTGAAIATTIGRSIGVLYQLYHLFKgkgriqiRRRHLK----LDWAIIK---KIIKIAVGGILQFLIA-----SSSWI 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 234 SGILGMVELGAQSIT-YELAIIVYM---IPS-GFSVAANVRVGNALGAGNIDQAKKSsaisLIVTELFAVTFC-----VL 303
Cdd:cd13139 261 FLVRIIAEFGSTALAgYTIAIRIIMfalLPAwGLSNAAATLVGQNLGAGQPDRAEKS----VWRAGKYNMVFLgivslVF 336
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 304 LLGCKDLVGyIFTTDRDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQKVGAIVNAIGYYVIGLPIGIALMFAAKL 383
Cdd:cd13139 337 FLFAEPLVS-FFTTDPEVIAIAVEALRIISLGYIFYGYGMVLSQAFNGAGDTKTPTLINLVGFWLFQIPLAYLLARHLNL 415
|
410 420 430
....*....|....*....|....*....|.
gi 755539399 384 GVIGLWSGIIICTTCQTTCFLAFIARLNWKR 414
Cdd:cd13139 416 GPKGVFIAIPIAETVLAIAAIILFRRGKWKT 446
|
|
| MATE_like_4 |
cd13144 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
1-389 |
3.73e-17 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240549 [Multi-domain] Cd Length: 434 Bit Score: 83.82 E-value: 3.73e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 1 MMF---LISFISSVFCGHLGKLELDAVTLAIAVINVTgISVGHGLSSACDTLISQTYGSQNLKHVGVILQRG-TLILLLC 76
Cdd:cd13144 20 SMLfqaLYNIVDSIFVARLGENALTAVSLAFPIQNLM-IAVAVGTGVGVNALLSRSLGEKDQKEANKAANNGlLLALLSY 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 77 CFPCWALFINTEQILLLFRQDPDVSRLTQTYVMIFIPALPAAFLYTLQVKYLLNQGIVLPQIMTGIAANLVNALANYVFL 156
Cdd:cd13144 99 LLFLLLGLFGVKPFFRLFTDDPEILEYGYAYLSWCVIFSFGMFFQILCEKVLQSTGNTITPMIAQLIGAIINIILDPILI 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 157 YHLH----LGVMGSALANTISQFALAIFLFLYILWR--------RLHQATWggwsweclQDWASFLRLAIPSMLMLCIew 224
Cdd:cd13144 179 FGLFgfpaMGIAGAAIATVIGQILAMFLAFFFLLRKnkdvqpdlRLFRPSL--------RIIKEIYAVGLPSIIMQAI-- 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 225 wayevGSFLSGILGMVELG-------AQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKKSSAISLIVTELFA 297
Cdd:cd13144 249 -----SSVMVFGLNKILAGfgptavaVFGIYFKLQSFVFMPVFGLNNGLIPIVAYNYGAGNKDRIREAIKYAILIAVVIM 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 298 VTFCVLLLGCKDLVGYIFTTDRDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQKVGAIVNAIGYYVIGLPigIAL 377
Cdd:cd13144 324 LAGGLLFQLFPDQLLGLFNASEEMLAIGVPALRIISLSFLFAALSIILSGLFQALGRGVYSLIISVARQLVVLLP--LAW 401
|
410
....*....|..
gi 755539399 378 MFAAKLGVIGLW 389
Cdd:cd13144 402 LLAKMFGLNGVW 413
|
|
| MATE_like_9 |
cd13135 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
4-394 |
4.83e-16 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240540 [Multi-domain] Cd Length: 429 Bit Score: 80.41 E-value: 4.83e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 4 LISFISSVFCGHLGKLELDAVTLAIAVINvTGISVGHGLSSACDTLISQTYGSQNLKHVGVILQ---RGTLILLLCCFPC 80
Cdd:cd13135 19 LQMLVDRAFLGRISIRYYSAVGNVTTPFN-TITGFLGSISIGFTILGSQSVGAKDIKRINDYAIssiVYNSIIGVILFLL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 81 WalFINTEQILLLFRQDPDVSRLTQTYVMIFIPALP-AAFLYTLQVkYLLNQGIVLPQIMTGIAANLVNALANYVFLY-H 158
Cdd:cd13135 98 W--LFGARIIFVLFGVDGQILGYSINYVRIFSIYLLlLGILFTFSS-ILQGIGETKPIMYGGIIKNLLNVILDYVLIFgN 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 159 L---HLGVMGSALANTISQFALAIFLFLYIL-WRRLHQATWGGWS-WECLQDWASFLRLAIPSMLMLcIEWWAYE--VGS 231
Cdd:cd13135 175 FgfpRLGIIGAAIATTIANVLNLIILVYLCRkIKKLTFKLSNTKVlKANIRPYKFTIKLGLPLGGEE-FLWNIGNlaVIR 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 232 FLSGIlGMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKKSSAISLIVTELFAVTFCVLLLGCKDLV 311
Cdd:cd13135 254 ILNRI-GELALGIYTLVFGIENIVLMPMYGYSSAALTLVGESIGKKDLKEALRIGNICLGLGLLIYIAAAIVFLAFPYKI 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 312 GYIFTTDRDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQKVGAIVNAIGyYVIGLPIGIALMFAAKLGVIGLWSG 391
Cdd:cd13135 333 LSLFTNDPELINYSIPYLIFIIIILFFKSINIVYGFAIRAIGDTKWMLYTQIIG-TIIVVSVALLLIFVFKLGLAGVYIT 411
|
...
gi 755539399 392 III 394
Cdd:cd13135 412 LFI 414
|
|
| MATE_like_2 |
cd13149 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
2-394 |
7.82e-14 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240554 [Multi-domain] Cd Length: 434 Bit Score: 73.49 E-value: 7.82e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 2 MFLISFISSVFCGHLGKLELDAVTLAIAVINVTGiSVGHGLSSACDTLISQTYGSQNLKHV------GVILqrgTLILLL 75
Cdd:cd13149 25 MLIFNLTDTFFVGKLGTKELAAISFTFPVVLFLN-SLTIGLGIGASAVISRAIGAGDRNKAkrlatdSLIL---SLLLSV 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 76 CCFPCWALFIntEQILLLFRQDPDVSRLTQTYVMIFIPALPAAFLYTLQVKYLLNQG-IVLPQIMTGIAAnLVNALANYV 154
Cdd:cd13149 101 IVSLLGLFTI--PPLFSLLGASGEILPLIVEYMAIWYLGLVFLVLPMVGNAIIRATGdTKRPSLVMLGAA-LVNVILDPI 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 155 FLYHL----HLGVMGSALANTISQFALAIFLfLYILWRRLHQATWGGWSW-ECLQDWASFLRLAIPSMLMLCIEWWAYEV 229
Cdd:cd13149 178 LIFGFgpipGMGIAGAAIATVISRALGLGAA-LYFLHYHHRLIDFSEPSLkALFRSWKDILSIGIPAALSNILTPLSAAF 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 230 GSFLSGILGMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKKSSAISLIVTELF-AVTFCVLLLGCK 308
Cdd:cd13149 257 ITALVATYGPAAVAAFGVATRIESFAFIIVMALSSALGPFVGQNWGAGQYERVQEGLKISLKFSLIYgAILGIVLALFAG 336
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 309 DLVGyIFTTDRDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQKVGAIVNAIGYYVIGLPigIALMFAAKLGVIGL 388
Cdd:cd13149 337 WLAS-LFSAEPEVIELITLYLLIVPIGYGGLGILIITSASFNALGKPLYSLGLNLIRVFLLYIP--LAYVGSHLLGFAGV 413
|
....*.
gi 755539399 389 WSGIII 394
Cdd:cd13149 414 FIGALA 419
|
|
| MATE_like_6 |
cd13146 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
36-410 |
1.87e-13 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240551 [Multi-domain] Cd Length: 433 Bit Score: 72.43 E-value: 1.87e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 36 ISVGHGLSSACDTLISQTYGSQNLKHVGVILQRGTLILLLCCFPCWAL-FINTEQILLLFRQDPDVSRLTQTYVMIFIPA 114
Cdd:cd13146 60 LALGNGIQVGVSSLLARAIGAQRAKELDQAADSGLALALLAATVIVVLgYIFAEPLLQLLGAKGLLLEYALEYFYYSLPG 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 115 LPAAFLYTLQVKYLLNQGIVLPQIMTGIAANLVNALANYVFLYHLHLGVMGSALANTISQFALAIFLFLYILWR----RL 190
Cdd:cd13146 140 VPFIMLIGVLMGVLQGEGRTKYMMMAMLIGTVVNIVLDPILIFVFDMGVKGAALATVLAQAISLLYLLYVFLIGksnvTI 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 191 HQATWGGwSWECLqdwASFLRLAIPSMLMLCIEWWAYEVGSFLSGILGMVELGAQSITYELAIIVYMIPSGFSVAANVRV 270
Cdd:cd13146 220 HIKLSNI-SSSVI---VEILRVGLPQMLLQLISSISFLIYNRIIIDIDPVAMTAFTLVGRLDQFILIPIFAISSALLTIA 295
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 271 GNALGAGNIDQAKKSSAISLIVTELFAVTFCVLLLGCKDLVGYIFTTDRDIVALVAQVIPIYAVSHLFEGLACTCGGILR 350
Cdd:cd13146 296 GQNWGRGNYDRMLQILMTAVILGIVVVLVLVLGYVLVAPWLFSLFTTVPEVVAYAVLQVRTMALALPFVAISILVTEFFQ 375
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 351 GTGNQKVGAIVNAIGYYVIGLPIGIALMFAAKLGVIGLWSGIIICTTcqTTCFLAFIARL 410
Cdd:cd13146 376 AIGKAWPSLLLTLIRHVFLSVPVVYLLAYVFGKGITGVYFGIVSANF--FTALLAMFWGL 433
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
206-409 |
3.81e-12 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 68.25 E-value: 3.81e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 206 WASFLRLAIPSMLMLCIEwWAYE-VGSFLSGILGMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKK 284
Cdd:COG0534 7 LKLLLRLALPIILGNLLQ-SLYGlVDTIFVGRLGTAALAAVGLAFPIFFLLIALGIGLGVGGTALVAQALGAGDREEARR 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 285 SSAISLIVTELFAVTFCVLLLGCKDLVGYIFTTDRDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQKVGAIVNAI 364
Cdd:COG0534 86 VLGQALLLALLLGLLLTLLGLLFAPPLLRLLGADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPMIIMLI 165
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 755539399 365 GyYVIGLPIGIALMFAAKLGVIGLWSGIIICTTCQTTCFLAFIAR 409
Cdd:COG0534 166 G-NVLNIVLDPLLIFGGGLGVAGAALATVISQAVSALLLLYYLFR 209
|
|
| MATE_like_13 |
cd13141 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
12-409 |
6.35e-12 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240546 [Multi-domain] Cd Length: 443 Bit Score: 67.34 E-value: 6.35e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 12 FCGHLGKLELDAVTLAIAVINVTgISVGHGLSSACDTLISQTYGSQNLKHVGVILQRGTLILLLCCFPCWALFINTEQIL 91
Cdd:cd13141 37 FVGQLGDAALAGVSLAGNVMFFV-MALTQVLNVGTAALVSHAVGRKDQGEANAVFNQSLLLAAVLGLVVLVLGYLFGRLY 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 92 LLF-RQDPDVSRLTQTYVMIFIPALPAAFLYTLQVKYLLNQGIVLPQIMTGIAANLVNALANYVFLY----HLHLGVMGS 166
Cdd:cd13141 116 LETlAADAATVEAATTYLYWFIPSLALQFILTVLGAALRGTGIVKPFMVIQILAVLLNIILAPILITgwgtGRALGVAGA 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 167 ALANTISQFALAIFLFLYILW-RRLHQATWGGWSWEcLQDWASFLRLAIPS----MLMLC----IEWWAYEVGS-----F 232
Cdd:cd13141 196 GLASSISVAIAVVLLLYYFLRlEKYLRLDLALWRPD-LPTWKRLLKIGLPSggefLLTFVymavIYWALRPFGAaaqagF 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 233 LSG--ILGMVELGAQSITYELAIIVymipsgfsvaanvrvGNALGAGNIDQAKKSSAISLIVTELFAVTFCVLLLGCKDL 310
Cdd:cd13141 275 GIGsrIMQSLFLPAMAIAFAAPAIA---------------GQNFGAGNYDRVRETFRITAILTTALMLVLTLLCQLVPEL 339
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 311 VGYIFTTDRDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQKVGAIVNAIGYYVIGLPIgIALMFAAKLGVIGLWS 390
Cdd:cd13141 340 LVTPFSDDAAVIAVAATFLRYVSWNFVAAGLVFTCSGMFQALGNTWPSLLSSASRLLTFALPV-IWLSAQPDFRIEQIWY 418
|
410
....*....|....*....
gi 755539399 391 GIIICTTCQTTCFLAFIAR 409
Cdd:cd13141 419 LSVATTILQAALSLLLLRR 437
|
|
| MATE_like_4 |
cd13144 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
210-387 |
7.98e-09 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240549 [Multi-domain] Cd Length: 434 Bit Score: 57.63 E-value: 7.98e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 210 LRLAIPSMLMLCIEWWAYEVGSFLSGILGMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKKSSAIS 289
Cdd:cd13144 11 LTMSIPAMISMLFQALYNIVDSIFVARLGENALTAVSLAFPIQNLMIAVAVGTGVGVNALLSRSLGEKDQKEANKAANNG 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 290 LIVTELFAVTFCVLLLGCKDLVGYIFTTDRDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGN-------QKVGAIVN 362
Cdd:cd13144 91 LLLALLSYLLFLLLGLFGVKPFFRLFTDDPEILEYGYAYLSWCVIFSFGMFFQILCEKVLQSTGNtitpmiaQLIGAIIN 170
|
170 180
....*....|....*....|....*.
gi 755539399 363 aigyyVIGLPIGI-ALMFAAKLGVIG 387
Cdd:cd13144 171 -----IILDPILIfGLFGFPAMGIAG 191
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
210-414 |
2.25e-08 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 56.37 E-value: 2.25e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 210 LRLAIPSMLMLCIEWWAYEVGSFLSGILGMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKKSSAIS 289
Cdd:cd13137 4 WSLAWPVILENLLQTLVGLVDVFMVGRLGAEAIAAVGLATQVLWLLLVLNMALGTGTVALVSQSYGAGDYERARRALGQS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 290 LIVTELFAVTFCVLLLGCKDLVGYIFTTDRDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQK-------VGAIVN 362
Cdd:cd13137 84 LLLALLLSLPLALLGLLFAEPLLRLLGADPEVIALALTYLRIVLLGIPFFFLSLVGNAALRGAGDTKtpmyimiIVNVLN 163
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 755539399 363 AIGYYVIGLPIGIALmfaaKLGVIGLWSGIIICTTCQTTCFLAFIARLNWKR 414
Cdd:cd13137 164 IVLDYVLIFGLWGFP----GLGVAGAALATVISRVVGALLLLFLLLRGRLPI 211
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
206-376 |
4.00e-07 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 52.46 E-value: 4.00e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 206 WASFLRLAIPSMLMLCIE--------WWayeVGSFlsgiLGMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAG 277
Cdd:cd13138 2 LKTLLLFALPLLLSNLLQqlynlvdlLI---VGQF----LGVAALAAVSNGSPIIFLLTAIGMGLSMGGTILISQYIGAK 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 278 NIDQAKKSSAISLIVTELFAVTFCVLLLGCKDLVGYIFTTDRDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQK- 356
Cdd:cd13138 75 DEEKAKKAVGTLLVLFLILGIVLTILGLLFAPPILRLMNTPAEILELAVSYLRICFLGIPFIFGYNAYSAILRGLGDSKt 154
|
170 180
....*....|....*....|....*...
gi 755539399 357 ------VGAIVNAIG--YYVIGLPIGIA 376
Cdd:cd13138 155 plyfviIACVLNIILdlLFIAVFHMGVA 182
|
|
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
50-258 |
9.42e-07 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 51.30 E-value: 9.42e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 50 ISQTYGSQNLKHVGVILQRGTLILLLCCFPCWALFI--NTEQILLLF---RQDPDVSRLTQTYVMIFIPALPAAFLYTLQ 124
Cdd:COG0728 286 LSRAAAAGDLEEFRRTLSRGLRLVLLLTLPAAVGLIvlAEPIVRLLFergAFTAEDTALTALALAAYALGLPAFALVKVL 365
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 125 VKYLLNQGIVLPQIMTGIAANLVNALANYVFLYHLhlGVMGSALANTISQFALAIFLFlYILWRRLHQATWGGWsweclq 204
Cdd:COG0728 366 ARAFYARQDTRTPVRIAVIAVVVNIVLNLLLVPPL--GHAGLALATSLSALVNALLLL-VLLRRRLGGLPLRGI------ 436
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 755539399 205 dWASFLRLAIPSMLMLCIEWWAYEVGSFLSGILGMVELGAQSITYELAIIVYMI 258
Cdd:COG0728 437 -LRTLLKLLLASLVMGAVLWLLLRLLGDWLGGGLLGRLLALALLILVGAAVYFA 489
|
|
| MATE_like_5 |
cd13145 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
36-409 |
1.47e-06 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240550 [Multi-domain] Cd Length: 440 Bit Score: 50.67 E-value: 1.47e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 36 ISVGHGLSSACDTLISQTYGSQNLKHVGVILQRG-TLILLLCCFPCWALFINTEQILLLFRQDPDVSRLTQTYvmiFIPA 114
Cdd:cd13145 58 IAIGVGIGTGTTALIGNALGAGDRRKARRYAAQGlSFGIILAILLTVIGLFAAPPLFRLLGAEGDYLDLALEY---MDVI 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 115 LPAAFLYTLQvkYLLNqGIVLPQ---------IMTGIAANLV-NALANYVFLYHLHLGVMGSALANTISQFALAIFLFLY 184
Cdd:cd13145 135 FAGSIFFLLN--FGLN-GILNAQgdtksyrnfLIIGFFLNIIlDPLFIFGGGGIPAMGVSGIALATIISQFIGMFYLLYK 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 185 ILWRRLHQATWGGWSWECLQDWASFLRLAIPSML-MLCIEWWAYEVGSFLSGiLGMVELGAQSITYELAIIVYMIPSGFS 263
Cdd:cd13145 212 VRKSGIISGCRLRDFIPRLDVYKEILKQGFPASLnMMTIGLGIFVITYFVGQ-FGDEAVAAYGIALRIEQILLLPTIGLN 290
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 264 VAANVRVGNALGAGNIDQAKKSSAISLIVTELFAVTFCVLLLGCKDLVGYIFTTDRDIVALVAQVIPIYAVSHLFEGLAC 343
Cdd:cd13145 291 TAVLSIAGQNFGAKKYDRVRETYKKALKYGFVIMVVATVFLLFFAEPLMSLFTNDPAVIAIGAGYLRIDALIFYAYVVLF 370
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755539399 344 TCGGILRGTGNQKVGAIVNAIGYYVIGLPIGIALMFAAKLGVIGLWSGIIICTTCQTTCFLAFIAR 409
Cdd:cd13145 371 ISVSVLQGLKRPIFALWIGLYRQLVGPALVFWLLVNVLGLGVTGIWWGIFTIVWSAAIIALLYTRR 436
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
209-387 |
1.49e-06 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 50.59 E-value: 1.49e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 209 FLRLAIPSMLMLCIEwWAYEV--GSFLSGILGMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKKSS 286
Cdd:cd13143 6 FLKFALPAIIGMLVN-GLYNIvdGIFVGHGVGALALAAVNLVFPIIMLLMALGLMIGVGGASLISRRLGAGDREKANRIF 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 287 AISLIVTELFAVTFCVL-LLGCKDLVgYIFTTDRDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQK-------VG 358
Cdd:cd13143 85 STALLLSLILGLLLTILgLLFLDPLL-RLLGASGELLPYAVDYLRIILLGAPFTILSSVLNNLLRAEGKPKlamlgmlIG 163
|
170 180
....*....|....*....|....*....
gi 755539399 359 AIVNAIGYYViglpigiaLMFAAKLGVIG 387
Cdd:cd13143 164 AVLNIILDPL--------FIFVLGLGIAG 184
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
3-186 |
1.05e-05 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 47.70 E-value: 1.05e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 3 FLISFISSVFCGHLGKLELDAVTLAIAVINVTGISVGhGLSSACDTLISQTYGSQNLKHVGVILQRGTLI-LLLCCFPCW 81
Cdd:cd12082 237 LGLLIIVAIVAAFGGAAALAAYTVAFRIASLAFMPAL-GLAQAALPVVGQNLGAGNFDRARRITWVALLIgLLIGAVLGL 315
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 82 ALFINTEQILLLFRQDPDVSRLTQTYVMIFIPALPA-AFLYTLQvKYLLNQGIVLPQIMTGIAANLVNALANYVFLYHLH 160
Cdd:cd12082 316 LILLFPEPILSLFTNDPEFLELAVSYLRILAIYYLFvGIGYVLQ-AGFQAAGRTLKSLIVSLLSYWVVRLPLAYVLAYLG 394
|
170 180
....*....|....*....|....*.
gi 755539399 161 LGVMGSALANTISQFALAIFLFLYIL 186
Cdd:cd12082 395 LGLYGIWLALVISLILAALVLLLFFR 420
|
|
| MATE_MurJ_like |
cd13123 |
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
70-388 |
7.29e-05 |
|
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 45.14 E-value: 7.29e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 70 TLILLLCCFPCWALfinTEQILLLF--RQDPDVSRLTQTYVMIFIPALPAAFLYTLQVKYLLNQGIVLPQIMTGIAANLV 147
Cdd:cd13123 82 LLVLLLLTLLGILF---APLLVKLLapGFSGDKFELAVALTRIMFPYLLFISLSALLGGILNAHGRFFAPALAPVLLNLV 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 148 NALANYVFLYHLHLGVMGSALANTISQFALAIFLFLYiLWRRlhqatwgGWSWECLQDWAS-----FLRLAIPSMLMLCI 222
Cdd:cd13123 159 IIAGLLLLAPLFDLGIYALAWGVLLGGVLQLLVQLPA-LRRL-------GFRFRPRLDFRDpgvrrVLKLMLPALLGVSV 230
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 223 ewwaYEVGSFLSGILG-MVELGAQSITYeLAIIVYMIPSG-FSVAanvrVGNAL--------GAGNIDQAKK--SSAISL 290
Cdd:cd13123 231 ----SQINLLVDTILAsFLPEGSISALY-YADRLYQLPLGiFGVA----IATALlprlsrlaAAGDLDEFRRtlSRGLRL 301
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 291 IVTELFAVTFCVLLLGcKDLVGYIFTT---DRDIVALVAQVIPIYAVSHLFEGLActcgGIL-RG---TGNQKVGAIVNA 363
Cdd:cd13123 302 VLFLLLPAAVGLIVLA-EPIVRLLFERgafTAEDTLMTASALAAYALGLPAFALV----KLLsRAfyaLKDTKTPVKIAV 376
|
330 340
....*....|....*....|....*
gi 755539399 364 IGyyvIGLPIGIALMFAAKLGVIGL 388
Cdd:cd13123 377 IA---VAVNILLNLLLIKPLGHVGL 398
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
41-186 |
7.85e-05 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 45.19 E-value: 7.85e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 41 GLSSACDTLISQTYGSQNLKHVGVILQRGTLILLLCCFPCWALF-INTEQILLLFRQDPDVSRLTQTYVMIFIPALP-AA 118
Cdd:cd13143 281 GLSQGLQPIIGYNYGAGNYDRVKQALKLALIVALIYGLVLFLILlLFPEQIVSLFTDDPELIALAARILRIFLLAFPlAG 360
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755539399 119 FLYTLQVkYLLNQGIVLPQIMTGIAANLVnALANYVFLYHLHLGVMGSALANTISQFALAIFLFLYIL 186
Cdd:cd13143 361 INIVLSG-YFQAIGKAKRAALLSLLRQGL-FLIPLLLILPRLFGLDGIWLAFPLAEILTLLLALILLK 426
|
|
| MATE_Wzx_like |
cd13128 |
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
154-387 |
1.26e-04 |
|
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240533 [Multi-domain] Cd Length: 402 Bit Score: 44.46 E-value: 1.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 154 VFLYHLHLGVMGSALANTISQFALAIFLFlYILWRRLHQATWGGWSWEClqdWASFLRLAIPSMLMLCIEWWAYEVGSF- 232
Cdd:cd13128 157 LILVLLGGGLIGFALAYLIASVLSAILLL-YIYRKKILLPKFFSFDLKL---AKELLRFSIPLALSGIFSLIYTRIDTIm 232
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 233 LSGILGMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALgAGNIDQAKKSSAISLIVTELFAVTFCVLL-LGCKDLV 311
Cdd:cd13128 233 LGYFLGDAAVGIYNAAYRIAELLLFIPSAISTALFPRISELY-KNDKDELKKLLKKSFKYLFLISLPIAIGLfLFAEPII 311
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755539399 312 GYIFTTDrdiVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQKVGAIVNAIGyyvIGLPIGIALMFAAKLGVIG 387
Cdd:cd13128 312 TLLFGEE---YLPAALVLQILAWGFLFIFLNGIFGSILQAIGKQKLTLKILLIG---ALLNVILNLLLIPKYGIIG 381
|
|
| MATE_like_5 |
cd13145 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
229-377 |
1.38e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240550 [Multi-domain] Cd Length: 440 Bit Score: 44.51 E-value: 1.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 229 VGSFLSGILGMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKKSSAISLIVTELFAVTFCVLLLGCK 308
Cdd:cd13145 31 VDTFFAGKISTEALAALSLSFPIFFIIIAIGVGIGTGTTALIGNALGAGDRRKARRYAAQGLSFGIILAILLTVIGLFAA 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 309 DLVGYIFTTDRDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQK-------VGAIVNAI-------GYYVI---GL 371
Cdd:cd13145 111 PPLFRLLGAEGDYLDLALEYMDVIFAGSIFFLLNFGLNGILNAQGDTKsyrnfliIGFFLNIIldplfifGGGGIpamGV 190
|
....*.
gi 755539399 372 PiGIAL 377
Cdd:cd13145 191 S-GIAL 195
|
|
| MATE_like_3 |
cd13148 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
210-409 |
1.53e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240553 [Multi-domain] Cd Length: 441 Bit Score: 44.18 E-value: 1.53e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 210 LRLAIPSMLMLCIEWWAYEVGSFLSGILGMVELGAQSITYELAIIVYMIPSG-FSVAANVRVGNALGAGNIDQAKKSSAI 288
Cdd:cd13148 15 LRLALPNILALLVQTLVGLAETYFVGQLGTDALAGVALVFPLLMLTQMMSNGaMGGGVSSAIARALGAGDRERAEALVWH 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 289 SLIVTELFAVTFCVL-LLGCKDLVGYIFTTDRDIVA-------LVAQVIPIYAVSHLfeglactcGGILRGTGNQKVGAI 360
Cdd:cd13148 95 ALVIALAGGLVFSLLfLLFGPALYRLLGGRGEALDAalaysnvLFSGAILIWLVNLL--------AAALRGTGNMRVPAL 166
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 755539399 361 VNAIGyYVIGLPIGIALMF----AAKLGVIGLWSGIIICTTCQTTCFLAFIAR 409
Cdd:cd13148 167 VTLVG-AVVQIPLSPGLILgwgpLPRLGVAGAAVAAVLYYALAALVLLRYLAS 218
|
|
| vmrA |
PRK09575 |
MATE family efflux transporter; |
8-389 |
4.81e-04 |
|
MATE family efflux transporter;
Pssm-ID: 236576 [Multi-domain] Cd Length: 453 Bit Score: 42.67 E-value: 4.81e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 8 ISSVFCGH-LGKLELDAVTLAIAVINVT---GISVGHGLSSacdtLISQTYGSQNLKHVGVILQRG-TLILLLCCFPCWA 82
Cdd:PRK09575 34 VDGIFIGHyVGAEGLAGINMAWPVIGIIlgiGLMVGMGTGS----LLSIKRGEGDLEKAKRILTTGlLLLLLLGPIVSVI 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 83 LFINTEQILLLFRQDPDVSRLTQTYVMIFIPALPAAFLYTLQVKYLLNQGIvlPQIMTG--IAANLVNALANYVFLYHLH 160
Cdd:PRK09575 110 LFLFADDFLRAQGAEGRTLELALQYIQVLIWGCLFTLGAIALPFLLRNDES--PNLATGlmVIGALINIVLDYLFIGWLD 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 161 LGVMGSALANTISQFALAIFLFLYILWRRlhqaTWGGWSWECLQDWASFLR----LAIPSMLMlciewwaYEVGSF---L 233
Cdd:PRK09575 188 WGLTGAAIATALAQLVVTVLGLGYFFSSR----ANIRLTLKELRFNWSLAPkivlLGSSSFFM-------YLYGSFvvaL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 234 SGILGM-----VELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKKSSAISLIVTELFAVTFCVLL-LGC 307
Cdd:PRK09575 257 HNRLFMeygsaLTVGAYAIVGYLMVLYYLVAEGIAEGMQPPVSYYFGARQYDNIKKLLKLAMKVTVLAGIAWVLLLnLFP 336
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 308 KDLVGYIFTTDRDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTgNQKVGAIVNAIGYYVIGLPIgiaLMFAAK-LGVI 386
Cdd:PRK09575 337 ETMIALFNSGDSELIAETIVGIRLHLFAMFLDGFLVLASAYFMAV-NQGGKALFISIGNMLIQLPF---LFILPKwLGVD 412
|
...
gi 755539399 387 GLW 389
Cdd:PRK09575 413 GVW 415
|
|
| MATE_SpoVB_like |
cd13124 |
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related ... |
35-191 |
9.54e-04 |
|
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240529 [Multi-domain] Cd Length: 434 Bit Score: 41.68 E-value: 9.54e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 35 GISVGHGLSSACDTLISQTYGSQNLKHVGVILQRGTLILLLCCFPC-WALFINTEQILLLFRQDPDVSRLTQTYVMIFIp 113
Cdd:cd13124 283 PTVIATALSTSLVPAISEAYAKGDKKELRRRINQALRLTLLIGLPAaVGLAVLAEPINTLLFGDSEGGLILQILAPSIL- 361
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 114 alpaaFLYTLQVKYLLNQGIVLPQI--MTGIAANLVNALANYVFLYHLhlGVMGSALANTISqFALAIFLFLYILWRRLH 191
Cdd:cd13124 362 -----FLSLQQVTAAILQGLGKVKIpvINLLIGLLVKIVLNYVLIPIF--GIYGAAIATVIG-FLVAALLNLRALKKLLG 433
|
|
| MATE_MJ0709_like |
cd13147 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, ... |
142-407 |
2.96e-03 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, similar to Methanocaldococcus jannaschii MJ0709; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240552 [Multi-domain] Cd Length: 441 Bit Score: 40.22 E-value: 2.96e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 142 IAANLVNALANYVFLYHLHLGVMGSALANTISQFALAIFLFLYILWRR-------LHQATwggWSWECLQDwasFLRLAI 214
Cdd:cd13147 164 VAGSILNIILDPIFIYTLGLGIAGAAWATVISMLISSLVLLYWFFVKKdtyvslsLKNFK---FDKKIVKD---ILKVGI 237
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 215 PSMLMLCIewWAYeVGSFLSGILGMVelgaqSITYelAIIVY----------MIPS-GFSVAANVRVGNALGAGNIDQAK 283
Cdd:cd13147 238 PASLEQLI--MSV-LMIILNLILVIV-----AGTD--GVAVYtagwrivsfaIIPLiGIATAVTSVTGAAYGARNYEKLK 307
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539399 284 KSSAISLIVTELFAVTFCVLLLGCKDLVGYIFT---TDRDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQKVGAI 360
Cdd:cd13147 308 TAYNYSIKLGLIIELIIAILIFIFAPQIAYLFTyseESAHLAPEIVAFLRIMCLFLPFVPFGMMSSSMFQGIGKGLTSLI 387
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 755539399 361 VNAIgyYVIGLPIGIALMFAA--KLGVIGLWSGIIICTTCqtTCFLAFI 407
Cdd:cd13147 388 ITIL--RELIFQVLFAYLFAIvlGLGLFGVWWGIVLGNAI--GSIVGYL 432
|
|
| |
