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Conserved domains on  [gi|755509210|ref|XP_011248477|]
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PR domain zinc finger protein 2 isoform X7 [Mus musculus]

Protein Classification

PRDM2 family SET domain-containing protein( domain architecture ID 14443088)

PRDM2 (PR domain zinc finger protein 2) family SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain-containing protein may function as a protein-lysine N-methyltransferase, catalyzing the S-adenosyl-L-methionine (SAM)-dependent methylation at specific lysine residues of target proteins such as histones; similar to Homo sapiens PR domain zinc finger protein 2 isoform d

EC:  2.1.1.-
Gene Ontology:  GO:0005515|GO:1904047|GO:0016279
PubMed:  12372294|17013555

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PR-SET_PRDM2 cd19188
PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins; PRDM2 ...
 22-144 1.02e-84

PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins; PRDM2 (also termed GATA-3-binding protein G3B, lysine N-methyltransferase 8, MTB-or MTE-binding protein, PR domain-containing protein 2, retinoblastoma protein-interacting zinc finger protein, or zinc finger protein RIZ) is S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. It may function as a DNA-binding transcription factor.


:

Pssm-ID: 380965  Cd Length: 123  Bit Score: 246.97  E-value: 1.02e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755509210  22 LRGLPEEVRLLPSAVDKTRIGVWATKPILKGKKFGPFVGDKKKRSQVRNNVYMWEVYYPNLGWMCIDATDPEKGNWLRYV 101
Cdd:cd19188    1 LMGLPEELELKPSAVDKTRIGVWAKKSIPKGRKFGPFVGEKKKRSQVKNNVYMWEIYGPKRGWMCVDASDPTKGNWLRYV 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 755509210 102 NWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYNGEDN 144
Cdd:cd19188   81 NWARSGEEQNLFPLQINRAIYYKTLKPIAPGEELLCWYNGEDN 123
 
Name Accession Description Interval E-value
PR-SET_PRDM2 cd19188
PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins; PRDM2 ...
 22-144 1.02e-84

PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins; PRDM2 (also termed GATA-3-binding protein G3B, lysine N-methyltransferase 8, MTB-or MTE-binding protein, PR domain-containing protein 2, retinoblastoma protein-interacting zinc finger protein, or zinc finger protein RIZ) is S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. It may function as a DNA-binding transcription factor.


Pssm-ID: 380965  Cd Length: 123  Bit Score: 246.97  E-value: 1.02e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755509210  22 LRGLPEEVRLLPSAVDKTRIGVWATKPILKGKKFGPFVGDKKKRSQVRNNVYMWEVYYPNLGWMCIDATDPEKGNWLRYV 101
Cdd:cd19188    1 LMGLPEELELKPSAVDKTRIGVWAKKSIPKGRKFGPFVGEKKKRSQVKNNVYMWEIYGPKRGWMCVDASDPTKGNWLRYV 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 755509210 102 NWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYNGEDN 144
Cdd:cd19188   81 NWARSGEEQNLFPLQINRAIYYKTLKPIAPGEELLCWYNGEDN 123
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 34-146 2.12e-23

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 90.86  E-value: 2.12e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755509210    34 SAVDKTRIGVWATKPILKGKKFGPFVG------DKKKRSQVRNNVYMWEVYYPNLGW-MCIDATdpEKGNWLRYVNWACS 106
Cdd:smart00317   6 FKSPGKGWGVRATEDIPKGEFIGEYVGeiitseEAEERPKAYDTDGAKAFYLFDIDSdLCIDAR--RKGNLARFINHSCE 83

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 755509210   107 GEEQNLFPLEINRA-IYYKTLKPIAPGEELLVWYNGEDNPE 146
Cdd:smart00317  84 PNCELLFVEVNGDDrIVIFALRDIKPGEELTIDYGSDYANE 124
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 42-140 3.24e-18

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 77.18  E-value: 3.24e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755509210   42 GVWATKPILKGKKFGPFVG----------DKKKRSQVRNNVYMWEVYY---PNLGWMCIDATDPEKGNWLRYVNWACsge 108
Cdd:pfam00856   3 GLFATEDIPKGEFIGEYVEvllitkeeadKRELLYYDKLELRLWGPYLftlDEDSEYCIDARALYYGNWARFINHSC--- 79

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 755509210  109 EQN----LFPLEINRAIYYKTLKPIAPGEELLVWYN 140
Cdd:pfam00856  80 DPNcevrVVYVNGGPRIVIFALRDIKPGEELTIDYG 115
 
Name Accession Description Interval E-value
PR-SET_PRDM2 cd19188
PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins; PRDM2 ...
 22-144 1.02e-84

PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins; PRDM2 (also termed GATA-3-binding protein G3B, lysine N-methyltransferase 8, MTB-or MTE-binding protein, PR domain-containing protein 2, retinoblastoma protein-interacting zinc finger protein, or zinc finger protein RIZ) is S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. It may function as a DNA-binding transcription factor.


Pssm-ID: 380965  Cd Length: 123  Bit Score: 246.97  E-value: 1.02e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755509210  22 LRGLPEEVRLLPSAVDKTRIGVWATKPILKGKKFGPFVGDKKKRSQVRNNVYMWEVYYPNLGWMCIDATDPEKGNWLRYV 101
Cdd:cd19188    1 LMGLPEELELKPSAVDKTRIGVWAKKSIPKGRKFGPFVGEKKKRSQVKNNVYMWEIYGPKRGWMCVDASDPTKGNWLRYV 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 755509210 102 NWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYNGEDN 144
Cdd:cd19188   81 NWARSGEEQNLFPLQINRAIYYKTLKPIAPGEELLCWYNGEDN 123
PR-SET_PRDM7_9 cd19193
PR-SET domain found in PR domain zinc finger protein 7 (PRDM7) and 9 (PRDM9) and similar ...
 25-143 8.09e-38

PR-SET domain found in PR domain zinc finger protein 7 (PRDM7) and 9 (PRDM9) and similar proteins; PRDM7 (also termed PR domain-containing protein 7) is a primate-specific histone methyltransferase that is the result of a recent gene duplication of PRDM9. It selectively catalyzes the trimethylation of H3 lysine 4 (H3K4me3). PRDM9 (also termed PR domain-containing protein 9) is a histone methyltransferase that specifically trimethylates 'Lys-4' of histone H3 (H3K4me3) during meiotic prophase and is essential for proper meiotic progression. It also efficiently mono-, di-, and trimethylates H3K36. Aberrant PRDM9 expression is assciated with with genome instability in cancer.


Pssm-ID: 380970 [Multi-domain]  Cd Length: 129  Bit Score: 128.12  E-value: 8.09e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755509210  25 LPEEVRLLPSAVDKTRIGVWATKPILKGKKFGPFVGDKKKRSQVRNNVYMWEVYYPNLGWMCIDATDPEKGNWLRYVNWA 104
Cdd:cd19193    4 LPPGLSIKRSSIPGAGLGVWAEAPIPKGMVFGPYEGEIVEDEEAADSGYSWQIYKGGKLSHYIDAKDESKSNWMRYVNCA 83

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 755509210 105 CSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYnGED 143
Cdd:cd19193   84 RNEEEQNLVAFQYRGKIYYRTCKDIAPGTELLVWY-GDE 121
PR-SET_PRDM1 cd19187
PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins; PRDM1 ...
 24-139 9.01e-32

PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins; PRDM1 (also termed BLIMP-1, beta-interferon gene positive regulatory domain I-binding factor, PR domain-containing protein 1, positive regulatory domain I-binding factor 1, PRDI-BF1, or PRDI-binding factor 1) acts as a transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs.


Pssm-ID: 380964 [Multi-domain]  Cd Length: 128  Bit Score: 112.42  E-value: 9.01e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755509210  24 GLPEEVRLLPSAVDKTRIGVWATKPILKGKKFGPFVGDKKKRSQVRNNV---YMWEVYYPNLGWMCIDATDPEKGNWLRY 100
Cdd:cd19187    2 SLPRNLTLKYSSVGREVLGVWSSDYIPRGTRFGPLVGEIYTNDPVPKGAnrkYFWRIYSNGEFYHYIDGFDPSKSNWMRY 81

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 755509210 101 VNWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWY 139
Cdd:cd19187   82 VNPAHSLQEQNLVACQIGMNIYFYTVKPIPPNQELLVWY 120
PR-SET_PRDM16_PRDM3 cd19200
PR-SET domain found in PR domain zinc finger protein 16 (PRDM16), MDS1 and EVI1 complex locus ...
 25-146 3.62e-30

PR-SET domain found in PR domain zinc finger protein 16 (PRDM16), MDS1 and EVI1 complex locus protein and similar proteins; PRDM16 (also termed PR domain-containing protein 16, transcription factor MEL1, or MDS1/EVI1-like gene 1) functions as a transcriptional regulator. PRDM16 is preferentially expressed by hematopoietic and neuronal stem cells. It is closely related to paralog of PRDM3 (also termed MDS1 and EVI1 complex locus protein, ecotropic virus integration site 1 protein, EVI-1, myelodysplasia syndrome 1 protein, myelodysplasia syndrome-associated protein 1, or MECOM) which is a nuclear transcription factor essential for the proliferation/maintenance of hematopoietic stem cells (HSCs). PRDM3 and PRDM16 are both directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380977  Cd Length: 135  Bit Score: 108.61  E-value: 3.62e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755509210  25 LPEEVRLLPSAVDKTRIGVWATKPILKGKKFGPFVGdkKKRSQVRNNVYMWEV---YYPNLGWmcIDATDPEKGNWLRYV 101
Cdd:cd19200   10 IPPDFELRESAAVGAGLGVWTKVRIEVGEKFGPFVG--VQRSSVKDPTYAWEIvdeFGKVKFW--IDASEPGTGNWMKYI 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 755509210 102 NWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYNGEDNPE 146
Cdd:cd19200   86 RSAPSCEQQNLMACQIDEQIYYKVVRDIQPGEELLLYMKAAVYPH 130
PR-SET_PRDM-like cd10534
PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family ...
 25-140 9.59e-30

PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family of proteins is defined based on the conserved N-terminal PR domain, which is closely related to the Su(var)3-9, enhancer of zeste, and trithorax (SET) domains of histone methyltransferases, and is specifically called PR-SET domain. The family consists of 17 members in primates. PRDMs play diverse roles in cell-cycle regulation, differentiation, and meiotic recombination. The family also contains zinc finger protein ZFPM1 and ZFPM2. ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380932  Cd Length: 83  Bit Score: 105.74  E-value: 9.59e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755509210  25 LPEEVRLLPSAVDKTRIGVWATKPILKGKKFGPFVGDKkkrsqvrnnvymwevyypnlgwmcidatdpekgNWLRYVNWA 104
Cdd:cd10534    1 LPAGLELVLSSIPEGGLGVFARRTIPAGTRFGPLEGVV---------------------------------NWMRFVRPA 47

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 755509210 105 CSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYN 140
Cdd:cd10534   48 RNEEEQNLVAYQHGGQIYFRTTRDIPPGEELLVWYS 83
PR-SET_PRDM12 cd19196
PR-SET domain found in PR domain zinc finger protein 12 (PRDM12) and similar proteins; PRDM12 ...
 25-144 2.42e-29

PR-SET domain found in PR domain zinc finger protein 12 (PRDM12) and similar proteins; PRDM12 (also termed PR domain-containing protein 12) acts as a transcription factor that is involved in the positive regulation of histone H3-K9 dimethylation.


Pssm-ID: 380973 [Multi-domain]  Cd Length: 130  Bit Score: 106.29  E-value: 2.42e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755509210  25 LPEEVRLLPSAVDKTRIGVWATKPILKGKKFGPFVGDKKKRSQV---RNNVYMWEVYYPNlGWMC--IDATDPEKGNWLR 99
Cdd:cd19196    1 LPSQVIIAQSSIPGAGLGVFSKTWIKEGTEMGPYTGRIVSPEDVdpcKNNNLMWEVFNED-GTVShfIDASQENHRSWMT 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 755509210 100 YVNWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYNGEDN 144
Cdd:cd19196   80 FVNCARNEQEQNLEVVQIGESIYYRAIKDIPPDQELLVWYGNSYN 124
PR-SET_PRDM3 cd19214
PR-SET domain found in MDS1 and EVI1 complex locus protein and similar proteins; PRDM3 (also ...
 25-145 4.20e-26

PR-SET domain found in MDS1 and EVI1 complex locus protein and similar proteins; PRDM3 (also termed MDS1 and EVI1 complex locus protein, ecotropic virus integration site 1 protein, EVI-1, myelodysplasia syndrome 1 protein, myelodysplasia syndrome-associated protein 1, or MECOM) is a nuclear transcription factor, which is essential for the proliferation/maintenance of hematopoietic stem cells (HSCs). It is closely related to paralog PRDM16, both o fwhich are directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380991  Cd Length: 158  Bit Score: 98.86  E-value: 4.20e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755509210  25 LPEEVRLLPSAVDKTRIGVWATKPILKGKKFGPFVGDKkkRSQVRNNVYMWEVY--YPNLGWmCIDATDPEKGNWLRYVN 102
Cdd:cd19214   30 IPSEFELRESNIPGTGLGIWTKRKIEVGEKFGPYVGEQ--RSNLKDPSYGWEVLdeFGNVKF-CIDASQPDVGSWLKYIR 106

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 755509210 103 WACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYNGEDNP 145
Cdd:cd19214  107 FAGCYDQHNLVACQINDQIFYRAVADIDPGEELLLFMKSEDYS 149
PR-SET_PRDM14 cd19198
PR-SET domain found in PR domain zinc finger protein 14 (PRDM14) and similar proteins; PRDM14 ...
 25-139 3.85e-25

PR-SET domain found in PR domain zinc finger protein 14 (PRDM14) and similar proteins; PRDM14 (also termed PR domain-containing protein 14) acts as a transcription factor that has both positive and negative roles on transcription. It acts on regulating epigenetic modifications in the cells, playing a key role in the regulation of cell pluripotency, epigenetic reprogramming, differentiation and development. Aberrant PRDM14 expression is associated with tumorigenesis, cell migration and cell chemotherapeutic drugs resistance.


Pssm-ID: 380975  Cd Length: 133  Bit Score: 95.54  E-value: 3.85e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755509210  25 LPEEVRLLPSAVDKT-RIGVWATKPILKGKKFGPFVGDKKKRSQVR---NNVYMWEVYYP-NLGWMcIDATdPEKGNWLR 99
Cdd:cd19198    3 LPEGLRVLQTSFGGTpHYGVFCKKTIPKGTRFGPFRGRVVNTSEIKtydDNSFMWEIFEDgKLSHF-IDGR-GSTGNWMS 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 755509210 100 YVNWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWY 139
Cdd:cd19198   81 YVNCARYAEEQNLIAIQCQGQIFYESCKEILQGQELLVWY 120
PR-SET_PRDM6 cd19191
PR-SET domain found in PR domain zinc finger protein 6 (PRDM6) and similar proteins; PRDM6 ...
 25-140 8.91e-24

PR-SET domain found in PR domain zinc finger protein 6 (PRDM6) and similar proteins; PRDM6 (also termed PR domain-containing protein 6) is a putative histone-lysine N-methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. It may specifically methylate 'Lys-20' of histone H4 when associated with other proteins and in vitro.


Pssm-ID: 380968  Cd Length: 128  Bit Score: 91.77  E-value: 8.91e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755509210  25 LPEEVRLLPSAVDKTRIGVWATKPILKGKKFGPFVGDKKKRSQ----VRNNVYMWEVYYPNlGWMC--IDATDPEKGNWL 98
Cdd:cd19191    1 LPDEVCLCTSSIPGLGYGICAAQRIPQGTWIGPFEGVLVSPEKqigaVRNTQHLWEIYDQE-GTLQhfIDGGDPSKSSWM 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 755509210  99 RYVNWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYN 140
Cdd:cd19191   80 RYIRCARHCGEQNLTVVQYRGCIFYRACRDIPRGTELLVWYD 121
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 34-146 2.12e-23

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 90.86  E-value: 2.12e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755509210    34 SAVDKTRIGVWATKPILKGKKFGPFVG------DKKKRSQVRNNVYMWEVYYPNLGW-MCIDATdpEKGNWLRYVNWACS 106
Cdd:smart00317   6 FKSPGKGWGVRATEDIPKGEFIGEYVGeiitseEAEERPKAYDTDGAKAFYLFDIDSdLCIDAR--RKGNLARFINHSCE 83

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 755509210   107 GEEQNLFPLEINRA-IYYKTLKPIAPGEELLVWYNGEDNPE 146
Cdd:smart00317  84 PNCELLFVEVNGDDrIVIFALRDIKPGEELTIDYGSDYANE 124
PR-SET_PRDM16 cd19213
PR-SET domain found in PR domain zinc finger protein 16 (PRDM16) and similar proteins; PRDM16, ...
 25-138 2.86e-22

PR-SET domain found in PR domain zinc finger protein 16 (PRDM16) and similar proteins; PRDM16, also termed PR domain-containing protein 16, or transcription factor MEL1, or MDS1/EVI1-like gene 1, functions as a transcriptional regulator. PRDM16 is preferentially expressed by hematopoietic and neuronal stem cells and is closely related to paralog of PRDM3, both of which are directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380990  Cd Length: 162  Bit Score: 89.16  E-value: 2.86e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755509210  25 LPEEVRLLPSAVDKTRIGVWATKPILKGKKFGPFVGdkKKRSQVRNNVYMWEVYYPNLGW------------------MC 86
Cdd:cd19213   20 IPSDFELRESSIPGAGLGVWAKRKIEAGERFGPYTG--VQRSTLKDTNFGWEQILNDVEVssqegcitkivddlgnekFC 97

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 755509210  87 IDATDPEKGNWLRYVNWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVW 138
Cdd:cd19213   98 VDAGQAGAGSWLKYIRVACSCDEQNLTACQINEQIYYKVIKDIEPGEELLVY 149
PR-SET_ZFPM cd19201
PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also ...
 25-140 3.49e-20

PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380978  Cd Length: 122  Bit Score: 82.39  E-value: 3.49e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755509210  25 LPEEVRLL-PSAVDKTRIGVWATKPILKGKKFGPFVGdkKKRSQVRNNVYMWEVYYPNL---GWMCIDATDPekGNWLRY 100
Cdd:cd19201    3 LPGELELRkPSQDAGRSGGVWAKQPLPEGTRFGPYPG--KLVKEPLDPSYEWKVEAQGSkggEGLLLLTEDS--GTWLKL 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 755509210 101 VNWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYN 140
Cdd:cd19201   79 VRSADDEDEANLILYFKGGQIWCEVTKDIPPGEELILVLR 118
PR-SET_PRDM4 cd19189
PR-SET domain found in PR domain zinc finger protein 4 (PRDM4) and similar proteins; PRDM4 ...
 25-139 1.11e-18

PR-SET domain found in PR domain zinc finger protein 4 (PRDM4) and similar proteins; PRDM4 (also termed PR domain-containing protein 4, or PFM1) may function as a transcription factor involved in cell differentiation.


Pssm-ID: 380966  Cd Length: 133  Bit Score: 78.66  E-value: 1.11e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755509210  25 LPEEVRLLPSAVDKTrIGVWATKPILKGKKFGPFVGDKKKRSQV-----RNNVYMWEVYYPNLGWMCIDATDPEKGNWLR 99
Cdd:cd19189    6 LPRQLYLRQSETGAE-VGVWTKETIPVRTCFGPLIGQQSHSAEVadwtdKAAPHIWKIYHNDVLEFCIITTDENECNWMM 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 755509210 100 YVNWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWY 139
Cdd:cd19189   85 FVRKARTREEQNLVAYPHDGKIYFCTSRDIPPDQELLFYY 124
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 42-140 3.24e-18

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 77.18  E-value: 3.24e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755509210   42 GVWATKPILKGKKFGPFVG----------DKKKRSQVRNNVYMWEVYY---PNLGWMCIDATDPEKGNWLRYVNWACsge 108
Cdd:pfam00856   3 GLFATEDIPKGEFIGEYVEvllitkeeadKRELLYYDKLELRLWGPYLftlDEDSEYCIDARALYYGNWARFINHSC--- 79

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 755509210  109 EQN----LFPLEINRAIYYKTLKPIAPGEELLVWYN 140
Cdd:pfam00856  80 DPNcevrVVYVNGGPRIVIFALRDIKPGEELTIDYG 115
PR-SET_PRDM5 cd19190
PR-SET domain found in PR domain zinc finger protein 5 (PRDM5) and similar proteins; PRDM5 ...
 25-143 4.07e-16

PR-SET domain found in PR domain zinc finger protein 5 (PRDM5) and similar proteins; PRDM5 (also termed PR domain-containing protein 5) is a sequence-specific DNA-binding transcription factor that represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1.


Pssm-ID: 380967  Cd Length: 127  Bit Score: 71.94  E-value: 4.07e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755509210  25 LPEEVRLLPSAVdKTRIGVWATKPILKGKKFGPFVGDKKKRSQVRNNV---YMWEVYYPNLGWMCI-DATDPEKGNWLRY 100
Cdd:cd19190    5 VPDRFSLKSSKV-QDGMGLYTARRVKKGEKFGPFAGEKRMPNELDESMdprLMWEVRGSKGEVLYIlDASNPRHSNWLRF 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 755509210 101 VNWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYNGED 143
Cdd:cd19190   84 VHEAPSQEQKNLAAIQEGENIFYLAVDDIETDTELLIGYLDSD 126
PR-SET_PRDM10 cd19194
PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins; PRDM10 ...
 36-139 4.75e-16

PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins; PRDM10 (also termed PR domain-containing protein 10, or tristanin) may be involved in transcriptional regulation.


Pssm-ID: 380971  Cd Length: 128  Bit Score: 71.61  E-value: 4.75e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755509210  36 VDKTRIGVWATKPILKGKKFGPFVGDKKKRSQVRNNVYMWEVYYPNLGW-MCIDATDPEKGNWLRYVNWACSGEEQNLFP 114
Cdd:cd19194   15 FGETLGGVFAKRRIPKRTQFGPLEGPLVKKSELKDNKIHPLELEEDDGEdLYFDLSDENKCNWMMFVRPAQNHLEQNLVA 94

                         90       100
                 ....*....|....*....|....*
gi 755509210 115 LEINRAIYYKTLKPIAPGEELLVWY 139
Cdd:cd19194   95 YQYGQEIYFTTIKNIEPKQELKVWY 119
PR-SET_PRDM15 cd19199
PR-SET domain found in PR domain zinc finger protein 15 (PRDM15) and similar proteins; PRDM15 ...
 42-139 2.82e-15

PR-SET domain found in PR domain zinc finger protein 15 (PRDM15) and similar proteins; PRDM15 (also termed PR domain-containing protein 15, or zinc finger protein 298 (ZNF298)) may be involved in transcriptional regulation. It plays an essential role as a chromatin factor that modulates the transcription of upstream regulators of WNT and MAPK-ERK signaling to safeguard naive pluripotency.


Pssm-ID: 380976  Cd Length: 126  Bit Score: 69.75  E-value: 2.82e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755509210  42 GVWATKPILKGKKFGPFVGDKKKRSQvRNNVYMWEVYYPNLGWMCIDATDPEKGNWLRYVNWACSGEEQNLFPLEINRAI 121
Cdd:cd19199   22 GVFALVPLVKRTQFGPFEAKRVARLD-GFAVFPLKVFEKDGSVVYLDTSNEDDCNWMMFVRPATDVEHQNLTAYQQGEDI 100

                         90
                 ....*....|....*...
gi 755509210 122 YYKTLKPIAPGEELLVWY 139
Cdd:cd19199  101 YFTTSRDIQPGAELRVWY 118
PR-SET_PRDM17 cd10520
PR-SET domain found in PR domain zinc finger protein 17 (PRDM17) and similar proteins; PRDM17 ...
 22-138 1.82e-13

PR-SET domain found in PR domain zinc finger protein 17 (PRDM17) and similar proteins; PRDM17 (also termed zinc finger protein 408 (ZNF408)) may be involved in transcriptional regulation.


Pssm-ID: 380918  Cd Length: 121  Bit Score: 64.75  E-value: 1.82e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755509210  22 LRGLPEEVRLLPSAVDKTRIGVWAT-KPILKGKKFGPFVGD---KKKRSQVRNNVymwevyyPNLGwMCIDATDPEK-GN 96
Cdd:cd10520    2 LRSLPPGLALGPSLAQEERLGVWCVgDALQKGTFLGPLEEElesHDLTEGGSPRQ-------EESG-QSGDVLACEQsSK 73

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 755509210  97 WLRYVNWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVW 138
Cdd:cd10520   74 WMRFACRARSEEESNVAVVRLSGRLHLRVCKDIEPGSELLLW 115
PR-SET_PRDM11 cd19195
PR-SET domain found in PR domain zinc finger protein 11 (PRDM11) and similar proteins; PRDM11 ...
 49-142 3.98e-12

PR-SET domain found in PR domain zinc finger protein 11 (PRDM11) and similar proteins; PRDM11 (also termed PR domain-containing protein 11) may be involved in transcription regulation.


Pssm-ID: 380972  Cd Length: 127  Bit Score: 61.41  E-value: 3.98e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755509210  49 ILKGKKFGPFVGDKKKRSQvRNNVYMWEVYYPNLGWMCIDATDPEKGNWLRYVNWACSGEEQNLFPLEINRAIYYKTLKP 128
Cdd:cd19195   28 IPKGHIFGPYEGQICTQDK-SSGFFSWLIVDKNNRYKSIDGSDETKANWMRYVVISREEREQNLLAFQHSEQIYFRACRD 106

                         90
                 ....*....|....
gi 755509210 129 IAPGEELLVWYNGE 142
Cdd:cd19195  107 IRPGEKLRVWYSED 120
PR-SET_PRDM8 cd19192
PR-SET domain found in PR domain zinc finger protein 8 (PRDM8) and similar proteins; PRDM8 ...
 32-142 1.49e-10

PR-SET domain found in PR domain zinc finger protein 8 (PRDM8) and similar proteins; PRDM8 (also termed PR domain-containing protein 8) may function as histone methyltransferase, preferentially acting on 'Lys-9' of histone H3.


Pssm-ID: 380969  Cd Length: 131  Bit Score: 57.06  E-value: 1.49e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755509210  32 LPSAVDKTRIGVWATKPILKGKKFGPFVG---------DKKKRSQVRNNVYMweVYYPNLGWMcidATDPEKGNWLRYVN 102
Cdd:cd19192   11 SKSVLTDIFTSVVTTTDIPAGTIFGPCVLsftlgydiaDIALKTTDKRVVPY--IFRVDTGAC---NGSSEPSDWLRLVQ 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 755509210 103 WACSGEEQNL-FPLEINRAIYYKTLKPIAPGEELLVWYNGE 142
Cdd:cd19192   86 PARDRHEQNLeAFRKNEGQVYFRTLRRIRKGEELLVWYSDE 126
SET_LegAS4-like cd10522
SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and ...
 42-140 4.19e-09

SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and similar proteins; LegAS4 is a type IV secretion system effector of Legionella pneumophila. It contains a SET domain that is involved in the modification of Lys4 of histone H3 (H3K4) in the nucleolus of the host cell, thereby enhancing heterochromatic rDNA transcription. It also contains an ankyrin repeat domain of unknown function at its C-terminal region.


Pssm-ID: 380920 [Multi-domain]  Cd Length: 122  Bit Score: 52.73  E-value: 4.19e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755509210  42 GVWATKPILKGKKFGPFVGDKKKRSQVRNNVYMWE----VYYPNLGWMCIDATdpEKGNWLRYVNwacSGEEQNLFPLEI 117
Cdd:cd10522   16 GLFAAETIAKGEFVGEYTGEVLDRWEEDRDSVYHYdplyPFDLNGDILVIDAG--KKGNLTRFIN---HSDQPNLELIVR 90

                         90       100
                 ....*....|....*....|....*..
gi 755509210 118 NRA----IYYKTLKPIAPGEELLVWYN 140
Cdd:cd10522   91 TLKgeqhIGFVAIRDIKPGEELFISYG 117
PR-SET_PRDM13 cd19197
PR-SET domain found in PR domain zinc finger protein 13 (PRDM13) and similar proteins; PRDM13 ...
 88-139 4.63e-07

PR-SET domain found in PR domain zinc finger protein 13 (PRDM13) and similar proteins; PRDM13 (also termed PR domain-containing protein 13) may be involved in transcriptional regulation. It mediates the balance of inhibitory and excitatory neurons in somatosensory circuits.


Pssm-ID: 380974  Cd Length: 103  Bit Score: 46.74  E-value: 4.63e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755509210  88 DATDPEKGN----WLRYVNWACSGEEQNLfplEI-----NRAIYYKTLKPIAPGEELLVWY 139
Cdd:cd19197   38 DYLVDESGSpateWIGLVRAARNNQEQNL---EAiadlpGGQIFYRALRDIQPGEELTVWY 95
SET_SpSet7-like cd10540
SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces ...
 118-142 2.43e-04

SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces pombe Set7 is a novel histone-lysine N-methyltransferase. The family also includes a viral histone H3 lysine 27 methyltransferase from Paramecium bursaria Chlorella virus 1 (PBCV-1).


Pssm-ID: 380938  Cd Length: 112  Bit Score: 39.54  E-value: 2.43e-04
                         10        20
                 ....*....|....*....|....*
gi 755509210 118 NRAIYYKTLKPIAPGEELLVWYNGE 142
Cdd:cd10540   85 NQTIVFYALRDIEAGEELTINYGDD 109
SET cd08161
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, ...
 97-140 2.10e-03

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, Enhancer-of-zeste, Trithorax (SET) domain superfamily corresponds to SET domain-containing lysine methyltransferases, which catalyze site and state-specific methylation of lysine residues in histones that are fundamental in epigenetic regulation of gene activation and silencing in eukaryotic organisms. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains has been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as N-SET and C-SET. C-SET forms an unusual and conserved knot-like structure of probable functional importance. In addition to N-SET and C-SET, an insert region (I-SET) and flanking regions of high structural variability form part of the overall structure. Some family members contain a pre-SET domain, which is found in a number of histone methyltransferases (HMTase), and a post-SET domain, which harbors a zinc-binding site.


Pssm-ID: 380914 [Multi-domain]  Cd Length: 72  Bit Score: 35.69  E-value: 2.10e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 755509210  97 WLRYVNWACsgeEQN----LFPLEINRAIYYKTLKPIAPGEELLVWYN 140
Cdd:cd08161   28 LARFINHSC---EPNcefeEVYVGGKPRVFIVALRDIKAGEELTVDYG 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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