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Conserved domains on  [gi|767910429|ref|XP_011508284|]
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large ribosomal subunit protein uL24m isoform X1 [Homo sapiens]

Protein Classification

KOW motif domain-containing protein( domain architecture ID 10149560)

KOW motif domain-containing protein such as the mitochondrial 39S ribosomal protein L24, a component of the mitochondrial large ribosomal subunit (mt-LSU)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RplX COG0198
Ribosomal protein L24 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L24 ...
 59-154 1.61e-19

Ribosomal protein L24 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L24 is part of the Pathway/BioSystem: Ribosome 50S subunit


:

Pssm-ID: 439968 [Multi-domain]  Cd Length: 104  Bit Score: 79.72  E-value: 1.61e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910429  59 GDTVEILEGKDAGKQGKVVQVIRQRNWVVVGGLNTHYRYIGKTMDYR-GTMIPSEAPLLHRQVKLVDPMDRKPTEIEWRF 137
Cdd:COG0198    8 GDTVIVIAGKDKGKRGKVLKVLPKKNRVIVEGVNIVKKHQKPNQQNPqGGIIEKEAPIHISNVMLVDPKTGKPTRVGFKV 87

                         90
                 ....*....|....*..
gi 767910429 138 TEAGERVRVSTRSGRII 154
Cdd:COG0198   88 LEDGKKVRVCKKSGEVI 104
 
Name Accession Description Interval E-value
RplX COG0198
Ribosomal protein L24 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L24 ...
 59-154 1.61e-19

Ribosomal protein L24 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L24 is part of the Pathway/BioSystem: Ribosome 50S subunit


Pssm-ID: 439968 [Multi-domain]  Cd Length: 104  Bit Score: 79.72  E-value: 1.61e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910429  59 GDTVEILEGKDAGKQGKVVQVIRQRNWVVVGGLNTHYRYIGKTMDYR-GTMIPSEAPLLHRQVKLVDPMDRKPTEIEWRF 137
Cdd:COG0198    8 GDTVIVIAGKDKGKRGKVLKVLPKKNRVIVEGVNIVKKHQKPNQQNPqGGIIEKEAPIHISNVMLVDPKTGKPTRVGFKV 87

                         90
                 ....*....|....*..
gi 767910429 138 TEAGERVRVSTRSGRII 154
Cdd:COG0198   88 LEDGKKVRVCKKSGEVI 104
KOW_RPL26 cd06089
KOW motif of Ribosomal Protein L26; RPL26 and its bacterial paralogs RPL24 have a KOW motif at ...
 59-122 6.24e-19

KOW motif of Ribosomal Protein L26; RPL26 and its bacterial paralogs RPL24 have a KOW motif at their N terminal. KOW domain is known as an RNA-binding motif that is shared so far among some families of ribosomal proteins, the essential bacterial transcriptional elongation factor NusG, the eukaryotic chromatin elongation factor Spt5, the higher eukaryotic KIN17 proteins and Mtr4. RPL26 makes a very minor contributions to the biogenesis, structure, and function of 60s ribosomal subunits. However, RPL24 is essential to generate the first intermediate during 50s ribosomal subunits assembly. RPL26 have an extra-ribosomal function to enhances p53 translation after DNA damage.


Pssm-ID: 240513  Cd Length: 65  Bit Score: 77.17  E-value: 6.24e-19
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767910429  59 GDTVEILEGKDAGKQGKVVQVIRQRNWVVVGGLNTHYRYIGKTM-DYRGTMIPSEAPLLHRQVKL 122
Cdd:cd06089    1 GDEVQVIRGKDKGKQGKVLKVDRKKNRVIVEGVNVVKKHVKPSQeNPQGGIIEVEAPIHISNVML 65
rplX_bact TIGR01079
ribosomal protein L24, bacterial/organelle; This model recognizes bacterial and organellar ...
 59-154 1.91e-18

ribosomal protein L24, bacterial/organelle; This model recognizes bacterial and organellar forms of ribosomal protein L24. It excludes eukaryotic and archaeal forms, designated L26 in eukaryotes. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273431 [Multi-domain]  Cd Length: 102  Bit Score: 76.92  E-value: 1.91e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910429   59 GDTVEILEGKDAGKQGKVVQVIRQRNWVVVGGLNTHYRYIGKTMDYR-GTMIPSEAPLLHRQVKLVDPMDRKPTEIEWRF 137
Cdd:TIGR01079   6 GDTVKVISGKDKGKRGKVLKVLPKKNKVIVEGVNMVKKHVKPVPANRqGGIIEKEAPIHISNVMLFDPKTGKATRVGYRF 85

                          90
                  ....*....|....*..
gi 767910429  138 TEAGERVRVSTRSGRII 154
Cdd:TIGR01079  86 EEDGKKVRVFKKNGEII 102
rpl24 CHL00141
ribosomal protein L24; Validated
 59-125 1.91e-10

ribosomal protein L24; Validated


Pssm-ID: 214374  Cd Length: 83  Bit Score: 55.42  E-value: 1.91e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767910429  59 GDTVEILEGKDAGKQGKVVQVIRQRNWVVVGGLNTHYRYI-GKTMDYRGTMIPSEAPLLHRQVKLVDP 125
Cdd:CHL00141  12 GDTVKIISGSDKGKIGEVLKIIKKSNKVIVKGINIKFKHIkPNKENEVGEIKQFEAPIHSSNVMLYNE 79
ribosomal_L24 pfam17136
Ribosomal proteins 50S L24/mitochondrial 39S L24; This is the family of bacterial 50S ...
 91-151 2.84e-10

Ribosomal proteins 50S L24/mitochondrial 39S L24; This is the family of bacterial 50S ribosomal subunit proteins L24. It also carries some mitochondrial 39S L24 proteins.


Pssm-ID: 465359  Cd Length: 60  Bit Score: 53.99  E-value: 2.84e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767910429   91 LNTHYRYIGKTMDYR-GTMIPSEAPLLHRQVKLVDPMDRKPTEIEWRftEAGERVRVSTRSG 151
Cdd:pfam17136   1 VNMVKKHVKPSQQNPqGGIIEKEAPIHVSNVMLVDPKCGKPTRVGFK--EDGKKVRVSKKTG 60
KOW smart00739
KOW (Kyprides, Ouzounis, Woese) motif; Motif in ribosomal proteins, NusG, Spt5p, KIN17 and T54.
 59-82 3.86e-04

KOW (Kyprides, Ouzounis, Woese) motif; Motif in ribosomal proteins, NusG, Spt5p, KIN17 and T54.


Pssm-ID: 128978  Cd Length: 28  Bit Score: 36.54  E-value: 3.86e-04
                           10        20
                   ....*....|....*....|....
gi 767910429    59 GDTVEILEGKDAGKQGKVVQVIRQ 82
Cdd:smart00739   5 GDTVRVIAGPFKGKVGKVLEVDGE 28
 
Name Accession Description Interval E-value
RplX COG0198
Ribosomal protein L24 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L24 ...
 59-154 1.61e-19

Ribosomal protein L24 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L24 is part of the Pathway/BioSystem: Ribosome 50S subunit


Pssm-ID: 439968 [Multi-domain]  Cd Length: 104  Bit Score: 79.72  E-value: 1.61e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910429  59 GDTVEILEGKDAGKQGKVVQVIRQRNWVVVGGLNTHYRYIGKTMDYR-GTMIPSEAPLLHRQVKLVDPMDRKPTEIEWRF 137
Cdd:COG0198    8 GDTVIVIAGKDKGKRGKVLKVLPKKNRVIVEGVNIVKKHQKPNQQNPqGGIIEKEAPIHISNVMLVDPKTGKPTRVGFKV 87

                         90
                 ....*....|....*..
gi 767910429 138 TEAGERVRVSTRSGRII 154
Cdd:COG0198   88 LEDGKKVRVCKKSGEVI 104
KOW_RPL26 cd06089
KOW motif of Ribosomal Protein L26; RPL26 and its bacterial paralogs RPL24 have a KOW motif at ...
 59-122 6.24e-19

KOW motif of Ribosomal Protein L26; RPL26 and its bacterial paralogs RPL24 have a KOW motif at their N terminal. KOW domain is known as an RNA-binding motif that is shared so far among some families of ribosomal proteins, the essential bacterial transcriptional elongation factor NusG, the eukaryotic chromatin elongation factor Spt5, the higher eukaryotic KIN17 proteins and Mtr4. RPL26 makes a very minor contributions to the biogenesis, structure, and function of 60s ribosomal subunits. However, RPL24 is essential to generate the first intermediate during 50s ribosomal subunits assembly. RPL26 have an extra-ribosomal function to enhances p53 translation after DNA damage.


Pssm-ID: 240513  Cd Length: 65  Bit Score: 77.17  E-value: 6.24e-19
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767910429  59 GDTVEILEGKDAGKQGKVVQVIRQRNWVVVGGLNTHYRYIGKTM-DYRGTMIPSEAPLLHRQVKL 122
Cdd:cd06089    1 GDEVQVIRGKDKGKQGKVLKVDRKKNRVIVEGVNVVKKHVKPSQeNPQGGIIEVEAPIHISNVML 65
rplX_bact TIGR01079
ribosomal protein L24, bacterial/organelle; This model recognizes bacterial and organellar ...
 59-154 1.91e-18

ribosomal protein L24, bacterial/organelle; This model recognizes bacterial and organellar forms of ribosomal protein L24. It excludes eukaryotic and archaeal forms, designated L26 in eukaryotes. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273431 [Multi-domain]  Cd Length: 102  Bit Score: 76.92  E-value: 1.91e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910429   59 GDTVEILEGKDAGKQGKVVQVIRQRNWVVVGGLNTHYRYIGKTMDYR-GTMIPSEAPLLHRQVKLVDPMDRKPTEIEWRF 137
Cdd:TIGR01079   6 GDTVKVISGKDKGKRGKVLKVLPKKNKVIVEGVNMVKKHVKPVPANRqGGIIEKEAPIHISNVMLFDPKTGKATRVGYRF 85

                          90
                  ....*....|....*..
gi 767910429  138 TEAGERVRVSTRSGRII 154
Cdd:TIGR01079  86 EEDGKKVRVFKKNGEII 102
rpl24 CHL00141
ribosomal protein L24; Validated
 59-125 1.91e-10

ribosomal protein L24; Validated


Pssm-ID: 214374  Cd Length: 83  Bit Score: 55.42  E-value: 1.91e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767910429  59 GDTVEILEGKDAGKQGKVVQVIRQRNWVVVGGLNTHYRYI-GKTMDYRGTMIPSEAPLLHRQVKLVDP 125
Cdd:CHL00141  12 GDTVKIISGSDKGKIGEVLKIIKKSNKVIVKGINIKFKHIkPNKENEVGEIKQFEAPIHSSNVMLYNE 79
ribosomal_L24 pfam17136
Ribosomal proteins 50S L24/mitochondrial 39S L24; This is the family of bacterial 50S ...
 91-151 2.84e-10

Ribosomal proteins 50S L24/mitochondrial 39S L24; This is the family of bacterial 50S ribosomal subunit proteins L24. It also carries some mitochondrial 39S L24 proteins.


Pssm-ID: 465359  Cd Length: 60  Bit Score: 53.99  E-value: 2.84e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767910429   91 LNTHYRYIGKTMDYR-GTMIPSEAPLLHRQVKLVDPMDRKPTEIEWRftEAGERVRVSTRSG 151
Cdd:pfam17136   1 VNMVKKHVKPSQQNPqGGIIEKEAPIHVSNVMLVDPKCGKPTRVGFK--EDGKKVRVSKKTG 60
KOW pfam00467
KOW motif; This family has been extended to coincide with ref. The KOW (Kyprides, Ouzounis, ...
 59-88 3.95e-07

KOW motif; This family has been extended to coincide with ref. The KOW (Kyprides, Ouzounis, Woese) motif is found in a variety of ribosomal proteins and NusG.


Pssm-ID: 425698 [Multi-domain]  Cd Length: 32  Bit Score: 45.07  E-value: 3.95e-07
                          10        20        30
                  ....*....|....*....|....*....|
gi 767910429   59 GDTVEILEGKDAGKQGKVVQVIRQRNWVVV 88
Cdd:pfam00467   2 GDVVRVIAGPFKGKVGKVVEVDDKKNRVLV 31
Ribosomal_L26 pfam16906
Ribosomal proteins L26 eukaryotic, L24P archaeal; Ribosomal_L26 is a family of the 50S and the ...
 59-91 2.79e-04

Ribosomal proteins L26 eukaryotic, L24P archaeal; Ribosomal_L26 is a family of the 50S and the 60S ribosomal proteins from eukaryotes - L26 - and archaea - L25.


Pssm-ID: 465307 [Multi-domain]  Cd Length: 114  Bit Score: 39.03  E-value: 2.79e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 767910429   59 GDTVEILEGKDAGKQGKVVQVIRQRNWVVVGGL 91
Cdd:pfam16906  45 GDEVKVVRGDFKGREGKVVQVYRKKYRIHVEGV 77
KOW smart00739
KOW (Kyprides, Ouzounis, Woese) motif; Motif in ribosomal proteins, NusG, Spt5p, KIN17 and T54.
 59-82 3.86e-04

KOW (Kyprides, Ouzounis, Woese) motif; Motif in ribosomal proteins, NusG, Spt5p, KIN17 and T54.


Pssm-ID: 128978  Cd Length: 28  Bit Score: 36.54  E-value: 3.86e-04
                           10        20
                   ....*....|....*....|....
gi 767910429    59 GDTVEILEGKDAGKQGKVVQVIRQ 82
Cdd:smart00739   5 GDTVRVIAGPFKGKVGKVLEVDGE 28
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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