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Conserved domains on  [gi|767910437|ref|XP_011508288|]
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HHIP-like protein 2 isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
YliI COG2133
Glucose/arabinose dehydrogenase, beta-propeller fold [Carbohydrate transport and metabolism];
207-598 1.30e-86

Glucose/arabinose dehydrogenase, beta-propeller fold [Carbohydrate transport and metabolism];


:

Pssm-ID: 441736 [Multi-domain]  Cd Length: 365  Bit Score: 274.50  E-value: 1.30e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910437 207 LCLSEVANGLRNPVSMVHAGDGthRFFVAEQVGVVWVYLPDGsRLEQPFLDLKniVLTtpwiGDERGFLGLAFHPKFRHN 286
Cdd:COG2133   27 FTVEVVADGLDHPWGLAFLPDG--RLLVTERAGRIRLLDDDG-KLSTPVADLP--VFA----GGEGGLLGVALDPDFATN 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910437 287 RKFYIYYScldkkkveKIRISEMKVSRADPNKAD-LKSERVILEIEEPAS-NHNGGQLLFGLDGYMYIFTGDGGQAGDPF 364
Cdd:COG2133   98 GYLYVAYT--------DPGGAGTRVARFTLSDGDtLTSEEVILDGLPAGGgNHNGGRLAFGPDGKLYVSVGDRGNACEAR 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910437 365 GlfgNAQNKSSLLGKVLRIDVNraGShgkryrVPSDNPFVSEPGAHPAIYAYGIRNMWRCAVDRGDpitrqgrGRIFCGD 444
Cdd:COG2133  170 G---NAQDLNSLRGKILRIDPD--GS------IPADNPFVGTPGARPEIYAYGHRNPQGLAFDPET-------GELWATE 231
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910437 445 VGQNRFEEVDLILKGGNYGWRAKEGFACYDK--KLCHNASLDDvlPIYAYGHAVgkSVTGGYVYRGCESP-NLNGLYIFG 521
Cdd:COG2133  232 HGPDGGDELNRIEPGGNYGWPYCEGGQNYDPigDSTPDAGLTD--PVATWPPGH--APSGLAFYTGDAFPaEYRGGLFVA 307
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767910437 522 DFMSGRLMALQEDRKNKKWKKQDLclgsttscaFPGLISThskfIISFAEDEAGELYFLATSypsayapRGSIYKFV 598
Cdd:COG2133  308 DLGSRRVVRVPLDGDGKVVGEEDF---------LTGAGGR----PRDVAQGPDGALYVLDDN-------DGRIYRIT 364
Folate_rec super family cl03844
Folate receptor family; This family includes the folate receptor which binds to folate and ...
44-182 6.50e-11

Folate receptor family; This family includes the folate receptor which binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. These proteins are attached to the membrane by a GPI-anchor. The proteins contain 16 conserved cysteines that form eight disulphide bridges.


The actual alignment was detected with superfamily member pfam03024:

Pssm-ID: 397250  Cd Length: 172  Bit Score: 61.32  E-value: 6.50e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910437   44 QCLDYG--PPFQPP--LHLEFCSDYESFGCCDQ------HKDRRIAARYwdimeyfdlkRHELCG-------DYIKDILC 106
Cdd:pfam03024   1 VCLDGKhhKPKPSPepNLHELCAPWKENSCCTAntseeaHRDPSILYNF----------NWNHCGtlspeceKFFIQLQC 70
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767910437  107 -QECSPYAAHLYDAENTqTPLRNLPgLCSDYCSAFHSNCHSAISLLTNDR--GLQEShgrdGTRFChlldlPDKDYCFP 182
Cdd:pfam03024  71 fYECSPNLGPWIQPWRR-ERILNVP-LCKEFCDAWFEACKDDYTCKSNWGkgWLWSS----GKNGC-----PDEPSCRP 138
 
Name Accession Description Interval E-value
YliI COG2133
Glucose/arabinose dehydrogenase, beta-propeller fold [Carbohydrate transport and metabolism];
207-598 1.30e-86

Glucose/arabinose dehydrogenase, beta-propeller fold [Carbohydrate transport and metabolism];


Pssm-ID: 441736 [Multi-domain]  Cd Length: 365  Bit Score: 274.50  E-value: 1.30e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910437 207 LCLSEVANGLRNPVSMVHAGDGthRFFVAEQVGVVWVYLPDGsRLEQPFLDLKniVLTtpwiGDERGFLGLAFHPKFRHN 286
Cdd:COG2133   27 FTVEVVADGLDHPWGLAFLPDG--RLLVTERAGRIRLLDDDG-KLSTPVADLP--VFA----GGEGGLLGVALDPDFATN 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910437 287 RKFYIYYScldkkkveKIRISEMKVSRADPNKAD-LKSERVILEIEEPAS-NHNGGQLLFGLDGYMYIFTGDGGQAGDPF 364
Cdd:COG2133   98 GYLYVAYT--------DPGGAGTRVARFTLSDGDtLTSEEVILDGLPAGGgNHNGGRLAFGPDGKLYVSVGDRGNACEAR 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910437 365 GlfgNAQNKSSLLGKVLRIDVNraGShgkryrVPSDNPFVSEPGAHPAIYAYGIRNMWRCAVDRGDpitrqgrGRIFCGD 444
Cdd:COG2133  170 G---NAQDLNSLRGKILRIDPD--GS------IPADNPFVGTPGARPEIYAYGHRNPQGLAFDPET-------GELWATE 231
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910437 445 VGQNRFEEVDLILKGGNYGWRAKEGFACYDK--KLCHNASLDDvlPIYAYGHAVgkSVTGGYVYRGCESP-NLNGLYIFG 521
Cdd:COG2133  232 HGPDGGDELNRIEPGGNYGWPYCEGGQNYDPigDSTPDAGLTD--PVATWPPGH--APSGLAFYTGDAFPaEYRGGLFVA 307
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767910437 522 DFMSGRLMALQEDRKNKKWKKQDLclgsttscaFPGLISThskfIISFAEDEAGELYFLATSypsayapRGSIYKFV 598
Cdd:COG2133  308 DLGSRRVVRVPLDGDGKVVGEEDF---------LTGAGGR----PRDVAQGPDGALYVLDDN-------DGRIYRIT 364
GSDH pfam07995
Glucose / Sorbosone dehydrogenase; Members of this family are glucose/sorbosone dehydrogenases ...
216-464 1.44e-37

Glucose / Sorbosone dehydrogenase; Members of this family are glucose/sorbosone dehydrogenases that possess a beta-propeller fold.


Pssm-ID: 429776 [Multi-domain]  Cd Length: 327  Bit Score: 142.31  E-value: 1.44e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910437  216 LRNPVSMVHAGDGthRFFVAEQVGVVWVYLPDGSRLEQpfldlkniVLTTP--WIGDERGFLGLAFHPKFRHNRKFYIYY 293
Cdd:pfam07995   1 LEHPWGLAFLPDG--RMLVTERPGRLRIVDADGKLSTP--------IAGVPevAARGQGGLLDVALHPDFAENRWVYLSY 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910437  294 SCLDKKKvekiriSEMKVSRA--DPNKADLKSERVILEiEEPAS---NHNGGQLLFGLDGYMYIFTGDGGQagdpfglFG 368
Cdd:pfam07995  71 AEAGGGG------AGTAVARArlSDDGTALEDVEVIFR-QIPKVsggGHFGSRLVFGPDGTLFVTTGDRGD-------RD 136
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910437  369 NAQNKSSLLGKVLRIdvNRAGShgkryrVPSDNPFVSEPGAHPAIYAYGIRNMWRCAVdrgDPITrqgrGRIFCGDVGQN 448
Cdd:pfam07995 137 LAQDLDSHLGKILRL--NPDGS------IPADNPFVGRPGALPEIWSYGHRNPQGLAF---DPDT----GRLWEHEHGPR 201
                         250
                  ....*....|....*.
gi 767910437  449 RFEEVDLILKGGNYGW 464
Cdd:pfam07995 202 GGDEINLIEAGKNYGW 217
Folate_rec pfam03024
Folate receptor family; This family includes the folate receptor which binds to folate and ...
44-182 6.50e-11

Folate receptor family; This family includes the folate receptor which binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. These proteins are attached to the membrane by a GPI-anchor. The proteins contain 16 conserved cysteines that form eight disulphide bridges.


Pssm-ID: 397250  Cd Length: 172  Bit Score: 61.32  E-value: 6.50e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910437   44 QCLDYG--PPFQPP--LHLEFCSDYESFGCCDQ------HKDRRIAARYwdimeyfdlkRHELCG-------DYIKDILC 106
Cdd:pfam03024   1 VCLDGKhhKPKPSPepNLHELCAPWKENSCCTAntseeaHRDPSILYNF----------NWNHCGtlspeceKFFIQLQC 70
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767910437  107 -QECSPYAAHLYDAENTqTPLRNLPgLCSDYCSAFHSNCHSAISLLTNDR--GLQEShgrdGTRFChlldlPDKDYCFP 182
Cdd:pfam03024  71 fYECSPNLGPWIQPWRR-ERILNVP-LCKEFCDAWFEACKDDYTCKSNWGkgWLWSS----GKNGC-----PDEPSCRP 138
 
Name Accession Description Interval E-value
YliI COG2133
Glucose/arabinose dehydrogenase, beta-propeller fold [Carbohydrate transport and metabolism];
207-598 1.30e-86

Glucose/arabinose dehydrogenase, beta-propeller fold [Carbohydrate transport and metabolism];


Pssm-ID: 441736 [Multi-domain]  Cd Length: 365  Bit Score: 274.50  E-value: 1.30e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910437 207 LCLSEVANGLRNPVSMVHAGDGthRFFVAEQVGVVWVYLPDGsRLEQPFLDLKniVLTtpwiGDERGFLGLAFHPKFRHN 286
Cdd:COG2133   27 FTVEVVADGLDHPWGLAFLPDG--RLLVTERAGRIRLLDDDG-KLSTPVADLP--VFA----GGEGGLLGVALDPDFATN 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910437 287 RKFYIYYScldkkkveKIRISEMKVSRADPNKAD-LKSERVILEIEEPAS-NHNGGQLLFGLDGYMYIFTGDGGQAGDPF 364
Cdd:COG2133   98 GYLYVAYT--------DPGGAGTRVARFTLSDGDtLTSEEVILDGLPAGGgNHNGGRLAFGPDGKLYVSVGDRGNACEAR 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910437 365 GlfgNAQNKSSLLGKVLRIDVNraGShgkryrVPSDNPFVSEPGAHPAIYAYGIRNMWRCAVDRGDpitrqgrGRIFCGD 444
Cdd:COG2133  170 G---NAQDLNSLRGKILRIDPD--GS------IPADNPFVGTPGARPEIYAYGHRNPQGLAFDPET-------GELWATE 231
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910437 445 VGQNRFEEVDLILKGGNYGWRAKEGFACYDK--KLCHNASLDDvlPIYAYGHAVgkSVTGGYVYRGCESP-NLNGLYIFG 521
Cdd:COG2133  232 HGPDGGDELNRIEPGGNYGWPYCEGGQNYDPigDSTPDAGLTD--PVATWPPGH--APSGLAFYTGDAFPaEYRGGLFVA 307
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767910437 522 DFMSGRLMALQEDRKNKKWKKQDLclgsttscaFPGLISThskfIISFAEDEAGELYFLATSypsayapRGSIYKFV 598
Cdd:COG2133  308 DLGSRRVVRVPLDGDGKVVGEEDF---------LTGAGGR----PRDVAQGPDGALYVLDDN-------DGRIYRIT 364
GSDH pfam07995
Glucose / Sorbosone dehydrogenase; Members of this family are glucose/sorbosone dehydrogenases ...
216-464 1.44e-37

Glucose / Sorbosone dehydrogenase; Members of this family are glucose/sorbosone dehydrogenases that possess a beta-propeller fold.


Pssm-ID: 429776 [Multi-domain]  Cd Length: 327  Bit Score: 142.31  E-value: 1.44e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910437  216 LRNPVSMVHAGDGthRFFVAEQVGVVWVYLPDGSRLEQpfldlkniVLTTP--WIGDERGFLGLAFHPKFRHNRKFYIYY 293
Cdd:pfam07995   1 LEHPWGLAFLPDG--RMLVTERPGRLRIVDADGKLSTP--------IAGVPevAARGQGGLLDVALHPDFAENRWVYLSY 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910437  294 SCLDKKKvekiriSEMKVSRA--DPNKADLKSERVILEiEEPAS---NHNGGQLLFGLDGYMYIFTGDGGQagdpfglFG 368
Cdd:pfam07995  71 AEAGGGG------AGTAVARArlSDDGTALEDVEVIFR-QIPKVsggGHFGSRLVFGPDGTLFVTTGDRGD-------RD 136
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910437  369 NAQNKSSLLGKVLRIdvNRAGShgkryrVPSDNPFVSEPGAHPAIYAYGIRNMWRCAVdrgDPITrqgrGRIFCGDVGQN 448
Cdd:pfam07995 137 LAQDLDSHLGKILRL--NPDGS------IPADNPFVGRPGALPEIWSYGHRNPQGLAF---DPDT----GRLWEHEHGPR 201
                         250
                  ....*....|....*.
gi 767910437  449 RFEEVDLILKGGNYGW 464
Cdd:pfam07995 202 GGDEINLIEAGKNYGW 217
Folate_rec pfam03024
Folate receptor family; This family includes the folate receptor which binds to folate and ...
44-182 6.50e-11

Folate receptor family; This family includes the folate receptor which binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. These proteins are attached to the membrane by a GPI-anchor. The proteins contain 16 conserved cysteines that form eight disulphide bridges.


Pssm-ID: 397250  Cd Length: 172  Bit Score: 61.32  E-value: 6.50e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910437   44 QCLDYG--PPFQPP--LHLEFCSDYESFGCCDQ------HKDRRIAARYwdimeyfdlkRHELCG-------DYIKDILC 106
Cdd:pfam03024   1 VCLDGKhhKPKPSPepNLHELCAPWKENSCCTAntseeaHRDPSILYNF----------NWNHCGtlspeceKFFIQLQC 70
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767910437  107 -QECSPYAAHLYDAENTqTPLRNLPgLCSDYCSAFHSNCHSAISLLTNDR--GLQEShgrdGTRFChlldlPDKDYCFP 182
Cdd:pfam03024  71 fYECSPNLGPWIQPWRR-ERILNVP-LCKEFCDAWFEACKDDYTCKSNWGkgWLWSS----GKNGC-----PDEPSCRP 138
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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