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Conserved domains on  [gi|767913269|ref|XP_011508662|]
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NBAS subunit of NRZ tethering complex isoform X6 [Homo sapiens]

Protein Classification

Sec39 domain-containing protein( domain architecture ID 68656)

Sec39 domain-containing protein such as Arabidopsis thaliana MAG2 interacting protein 2 (MIP2) which functions as subunits of a tethering complex in plants.

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Sec39 super family cl15578
Secretory pathway protein Sec39; Mnaimneh et al identified Sec39p as a protein involved in ...
160-637 7.59e-14

Secretory pathway protein Sec39; Mnaimneh et al identified Sec39p as a protein involved in ER-Golgi transport in a large scale promoter shut down analysis of essential yeast genes. Kraynack et al. (2005) showed that Sec39p (Dsl3p) is required for Golgi-ER retrograde transport and is part of a very stable protein complex that also includes Dsl1p (in mammals ZW10), Tip20p (Rint-1) and the ER localized Q-SNARE proteins Ufe1p (syntaxin-18), Sec20p and Use1p. This was confirmed in a genome-wide analysis of protein complexes by Gavin et al (2006).


The actual alignment was detected with superfamily member pfam08314:

Pssm-ID: 429913  Cd Length: 725  Bit Score: 76.96  E-value: 7.59e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767913269   160 YEARCDVTLTLKELQQMKDIEKLRLLMNSCSEDKYVTSA--------------YQWMVPFLHRCEKQSPGVAN--ELLKE 223
Cdd:pfam08314  163 YYPDDSDTLSLEEFESLDDREAVNLLLSKTGSDNGENVGrdlrglvgpwlygkNRWKRRRLNEDDPGDDETCPgwEEVNE 242
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767913269   224 YLVTLAKGDLKFPL-KIFQHSKPD-----LQQKIIPDQDQLMAI-------ALECIYTCERNDQLCL------CYDLLEC 284
Cdd:pfam08314  243 WLLSQAAKSWGVAVnAFEQWDGPEdvdlgGDGTDSLDEDEQQELerryaraALAIIYLVPENSLEALegayriLSRLAEL 322
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767913269   285 LP-ERGYGDKTEATTKlhdMVDQLEQILSVSELLEKHGleKPISFVK----NTQSSSEEARKLMVRLTRHTGRKQPPVSE 359
Cdd:pfam08314  323 LDlLTESNPLTTPSSE---SISLLQALLLSAYILTSLG--HPCSVREaadlILLGDEEEQLAELRKLLRSLSKQGPKTDD 397
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767913269   360 SHWRTLLQDMLTMQ--QNVYTCLDSDACYEIFTESLLCSSRlenIHLAGQMMhcsacsENPPagiahkGKPHYRVSYEks 437
Cdd:pfam08314  398 KDWIKLRNELLWLSsgQGVFGRLSREEIESEILKALLSNGR---FDLAKEIY------EDSP------KQPLSSEQVE-- 460
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767913269   438 iDLVLAASREYFNSSTNLTDSCMDLARC--CLQLITDR----PPAIQEELDLIQAVGCLEEF------GVKILPLQVRLC 505
Cdd:pfam08314  461 -DVVLKAAWEAYDNASNGNRTRGGMKKAddILNAFPPTfpksSPEFKRLEALLAATHALSFYsltlqhGVPFKPVNIRVH 539
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767913269   506 PDRISLIKECISQSPTCYKQSTKLLGLAELLRVAGENP-----------------EERRgqVLILLVEQALRFHDYKAAS 568
Cdd:pfam08314  540 SDPLSLISKVLEQNPKSYTKLDDLLEIGRNLVEAMGLTgrdsdstpeslekerksAERR--ITAMCIEAALVEDDFETAY 617
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767913269   569 MHCQELMATGYPK--------------SWDVCSQLGQ------SEGYQDLAT-----------RQELMAFALTHCPPSSI 617
Cdd:pfam08314  618 SYVVNRLTPPSELptsasktndelddwSWRAALQAGKyrrpedTEIPTEIGTasgpeirhleqRMELLSQALRLAPPEEL 697
                          570       580
                   ....*....|....*....|
gi 767913269   618 ELLLAASSSLQTEILYQRVN 637
Cdd:pfam08314  698 EEVLNAWRRCEEELSSLLAQ 717
 
Name Accession Description Interval E-value
Sec39 pfam08314
Secretory pathway protein Sec39; Mnaimneh et al identified Sec39p as a protein involved in ...
160-637 7.59e-14

Secretory pathway protein Sec39; Mnaimneh et al identified Sec39p as a protein involved in ER-Golgi transport in a large scale promoter shut down analysis of essential yeast genes. Kraynack et al. (2005) showed that Sec39p (Dsl3p) is required for Golgi-ER retrograde transport and is part of a very stable protein complex that also includes Dsl1p (in mammals ZW10), Tip20p (Rint-1) and the ER localized Q-SNARE proteins Ufe1p (syntaxin-18), Sec20p and Use1p. This was confirmed in a genome-wide analysis of protein complexes by Gavin et al (2006).


Pssm-ID: 429913  Cd Length: 725  Bit Score: 76.96  E-value: 7.59e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767913269   160 YEARCDVTLTLKELQQMKDIEKLRLLMNSCSEDKYVTSA--------------YQWMVPFLHRCEKQSPGVAN--ELLKE 223
Cdd:pfam08314  163 YYPDDSDTLSLEEFESLDDREAVNLLLSKTGSDNGENVGrdlrglvgpwlygkNRWKRRRLNEDDPGDDETCPgwEEVNE 242
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767913269   224 YLVTLAKGDLKFPL-KIFQHSKPD-----LQQKIIPDQDQLMAI-------ALECIYTCERNDQLCL------CYDLLEC 284
Cdd:pfam08314  243 WLLSQAAKSWGVAVnAFEQWDGPEdvdlgGDGTDSLDEDEQQELerryaraALAIIYLVPENSLEALegayriLSRLAEL 322
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767913269   285 LP-ERGYGDKTEATTKlhdMVDQLEQILSVSELLEKHGleKPISFVK----NTQSSSEEARKLMVRLTRHTGRKQPPVSE 359
Cdd:pfam08314  323 LDlLTESNPLTTPSSE---SISLLQALLLSAYILTSLG--HPCSVREaadlILLGDEEEQLAELRKLLRSLSKQGPKTDD 397
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767913269   360 SHWRTLLQDMLTMQ--QNVYTCLDSDACYEIFTESLLCSSRlenIHLAGQMMhcsacsENPPagiahkGKPHYRVSYEks 437
Cdd:pfam08314  398 KDWIKLRNELLWLSsgQGVFGRLSREEIESEILKALLSNGR---FDLAKEIY------EDSP------KQPLSSEQVE-- 460
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767913269   438 iDLVLAASREYFNSSTNLTDSCMDLARC--CLQLITDR----PPAIQEELDLIQAVGCLEEF------GVKILPLQVRLC 505
Cdd:pfam08314  461 -DVVLKAAWEAYDNASNGNRTRGGMKKAddILNAFPPTfpksSPEFKRLEALLAATHALSFYsltlqhGVPFKPVNIRVH 539
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767913269   506 PDRISLIKECISQSPTCYKQSTKLLGLAELLRVAGENP-----------------EERRgqVLILLVEQALRFHDYKAAS 568
Cdd:pfam08314  540 SDPLSLISKVLEQNPKSYTKLDDLLEIGRNLVEAMGLTgrdsdstpeslekerksAERR--ITAMCIEAALVEDDFETAY 617
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767913269   569 MHCQELMATGYPK--------------SWDVCSQLGQ------SEGYQDLAT-----------RQELMAFALTHCPPSSI 617
Cdd:pfam08314  618 SYVVNRLTPPSELptsasktndelddwSWRAALQAGKyrrpedTEIPTEIGTasgpeirhleqRMELLSQALRLAPPEEL 697
                          570       580
                   ....*....|....*....|
gi 767913269   618 ELLLAASSSLQTEILYQRVN 637
Cdd:pfam08314  698 EEVLNAWRRCEEELSSLLAQ 717
 
Name Accession Description Interval E-value
Sec39 pfam08314
Secretory pathway protein Sec39; Mnaimneh et al identified Sec39p as a protein involved in ...
160-637 7.59e-14

Secretory pathway protein Sec39; Mnaimneh et al identified Sec39p as a protein involved in ER-Golgi transport in a large scale promoter shut down analysis of essential yeast genes. Kraynack et al. (2005) showed that Sec39p (Dsl3p) is required for Golgi-ER retrograde transport and is part of a very stable protein complex that also includes Dsl1p (in mammals ZW10), Tip20p (Rint-1) and the ER localized Q-SNARE proteins Ufe1p (syntaxin-18), Sec20p and Use1p. This was confirmed in a genome-wide analysis of protein complexes by Gavin et al (2006).


Pssm-ID: 429913  Cd Length: 725  Bit Score: 76.96  E-value: 7.59e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767913269   160 YEARCDVTLTLKELQQMKDIEKLRLLMNSCSEDKYVTSA--------------YQWMVPFLHRCEKQSPGVAN--ELLKE 223
Cdd:pfam08314  163 YYPDDSDTLSLEEFESLDDREAVNLLLSKTGSDNGENVGrdlrglvgpwlygkNRWKRRRLNEDDPGDDETCPgwEEVNE 242
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767913269   224 YLVTLAKGDLKFPL-KIFQHSKPD-----LQQKIIPDQDQLMAI-------ALECIYTCERNDQLCL------CYDLLEC 284
Cdd:pfam08314  243 WLLSQAAKSWGVAVnAFEQWDGPEdvdlgGDGTDSLDEDEQQELerryaraALAIIYLVPENSLEALegayriLSRLAEL 322
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767913269   285 LP-ERGYGDKTEATTKlhdMVDQLEQILSVSELLEKHGleKPISFVK----NTQSSSEEARKLMVRLTRHTGRKQPPVSE 359
Cdd:pfam08314  323 LDlLTESNPLTTPSSE---SISLLQALLLSAYILTSLG--HPCSVREaadlILLGDEEEQLAELRKLLRSLSKQGPKTDD 397
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767913269   360 SHWRTLLQDMLTMQ--QNVYTCLDSDACYEIFTESLLCSSRlenIHLAGQMMhcsacsENPPagiahkGKPHYRVSYEks 437
Cdd:pfam08314  398 KDWIKLRNELLWLSsgQGVFGRLSREEIESEILKALLSNGR---FDLAKEIY------EDSP------KQPLSSEQVE-- 460
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767913269   438 iDLVLAASREYFNSSTNLTDSCMDLARC--CLQLITDR----PPAIQEELDLIQAVGCLEEF------GVKILPLQVRLC 505
Cdd:pfam08314  461 -DVVLKAAWEAYDNASNGNRTRGGMKKAddILNAFPPTfpksSPEFKRLEALLAATHALSFYsltlqhGVPFKPVNIRVH 539
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767913269   506 PDRISLIKECISQSPTCYKQSTKLLGLAELLRVAGENP-----------------EERRgqVLILLVEQALRFHDYKAAS 568
Cdd:pfam08314  540 SDPLSLISKVLEQNPKSYTKLDDLLEIGRNLVEAMGLTgrdsdstpeslekerksAERR--ITAMCIEAALVEDDFETAY 617
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767913269   569 MHCQELMATGYPK--------------SWDVCSQLGQ------SEGYQDLAT-----------RQELMAFALTHCPPSSI 617
Cdd:pfam08314  618 SYVVNRLTPPSELptsasktndelddwSWRAALQAGKyrrpedTEIPTEIGTasgpeirhleqRMELLSQALRLAPPEEL 697
                          570       580
                   ....*....|....*....|
gi 767913269   618 ELLLAASSSLQTEILYQRVN 637
Cdd:pfam08314  698 EEVLNAWRRCEEELSSLLAQ 717
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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