sodium channel protein subunit alpha is the ion conducting pore forming subunit of the channel that mediates the voltage-dependent sodium ion permeability of excitable membranes
Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain ...
535-694
4.16e-89
Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain towards the start of voltage-dependent sodium ion channel proteins in eukaryotes. It is found closely associated with pfam06512 and pfam00520.
:
Pssm-ID: 463401 Cd Length: 163 Bit Score: 287.02 E-value: 4.16e-89
Sodium ion transport-associated; Members of this family contain a region found exclusively in ...
982-1187
3.43e-72
Sodium ion transport-associated; Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.
:
Pssm-ID: 461936 Cd Length: 195 Bit Score: 239.54 E-value: 3.43e-72
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1191-1466
9.84e-63
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
:
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 214.44 E-value: 9.84e-63
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1514-1770
5.43e-58
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
:
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 200.57 E-value: 5.43e-58
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
743-956
2.48e-54
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
:
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 190.17 E-value: 2.48e-54
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
125-410
1.24e-51
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
:
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 182.47 E-value: 1.24e-51
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of ...
1458-1510
2.09e-31
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of the intracellular linker between domains III and IV of the alpha subunits of voltage-gated sodium channels. It is responsible for fast inactivation of the channel and essential for proper physiological function.
:
Pssm-ID: 240441 Cd Length: 54 Bit Score: 117.67 E-value: 2.09e-31
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
1782-1829
2.90e-03
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.
The actual alignment was detected with superfamily member pfam16905:
Pssm-ID: 465306 Cd Length: 54 Bit Score: 37.63 E-value: 2.90e-03
Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain ...
535-694
4.16e-89
Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain towards the start of voltage-dependent sodium ion channel proteins in eukaryotes. It is found closely associated with pfam06512 and pfam00520.
Pssm-ID: 463401 Cd Length: 163 Bit Score: 287.02 E-value: 4.16e-89
Sodium ion transport-associated; Members of this family contain a region found exclusively in ...
982-1187
3.43e-72
Sodium ion transport-associated; Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.
Pssm-ID: 461936 Cd Length: 195 Bit Score: 239.54 E-value: 3.43e-72
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1191-1466
9.84e-63
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 214.44 E-value: 9.84e-63
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1514-1770
5.43e-58
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 200.57 E-value: 5.43e-58
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
743-956
2.48e-54
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 190.17 E-value: 2.48e-54
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
125-410
1.24e-51
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 182.47 E-value: 1.24e-51
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of ...
1458-1510
2.09e-31
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of the intracellular linker between domains III and IV of the alpha subunits of voltage-gated sodium channels. It is responsible for fast inactivation of the channel and essential for proper physiological function.
Pssm-ID: 240441 Cd Length: 54 Bit Score: 117.67 E-value: 2.09e-31
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
1782-1829
2.90e-03
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.
Pssm-ID: 465306 Cd Length: 54 Bit Score: 37.63 E-value: 2.90e-03
Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain ...
535-694
4.16e-89
Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain towards the start of voltage-dependent sodium ion channel proteins in eukaryotes. It is found closely associated with pfam06512 and pfam00520.
Pssm-ID: 463401 Cd Length: 163 Bit Score: 287.02 E-value: 4.16e-89
Sodium ion transport-associated; Members of this family contain a region found exclusively in ...
982-1187
3.43e-72
Sodium ion transport-associated; Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.
Pssm-ID: 461936 Cd Length: 195 Bit Score: 239.54 E-value: 3.43e-72
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1191-1466
9.84e-63
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 214.44 E-value: 9.84e-63
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1514-1770
5.43e-58
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 200.57 E-value: 5.43e-58
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
743-956
2.48e-54
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 190.17 E-value: 2.48e-54
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
125-410
1.24e-51
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 182.47 E-value: 1.24e-51
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of ...
1458-1510
2.09e-31
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of the intracellular linker between domains III and IV of the alpha subunits of voltage-gated sodium channels. It is responsible for fast inactivation of the channel and essential for proper physiological function.
Pssm-ID: 240441 Cd Length: 54 Bit Score: 117.67 E-value: 2.09e-31
Polycystin cation channel; This family contains the cation channel region from group II of ...
1546-1764
1.78e-05
Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.
Pssm-ID: 462341 [Multi-domain] Cd Length: 225 Bit Score: 48.04 E-value: 1.78e-05
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
1782-1829
2.90e-03
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.
Pssm-ID: 465306 Cd Length: 54 Bit Score: 37.63 E-value: 2.90e-03
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
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