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Conserved domains on  [gi|767927492|ref|XP_011511421|]
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zinc finger protein ZXDC isoform X1 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
168-382 1.07e-06

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.01  E-value: 1.07e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767927492 168 SGPSTPGYRCPEPQCALAFAKKHQLKVHL-LTHGGGQGRRPFKCPLEGCGWAFTTSYKLKRHLQSHDKLRPFGCPVGGCG 246
Cdd:COG5048  281 SSEKGFSLPIKSKQCNISFSRSSPLTRHLrSVNHSGESLKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSS 360

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767927492 247 KKFttvyNLKAHMKGHEqeslfkcevcaerfpthaklSSHQRSHFEPERPYKCDFPGCEKTFITVSALFSHNRAHFREQE 326
Cdd:COG5048  361 SKF----SPLLNNEPPQ--------------------SLQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRP 416

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767927492 327 LfSCSFPGCSKQYDKACRLKIHLRSHTGERPFICdsdsCGWTFTSMSKLLRHRRKH 382
Cdd:COG5048  417 Y-NCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC----SILKSFRRDLDLSNHGKD 467
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
316-527 8.55e-04

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.76  E-value: 8.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767927492 316 SHNRAHFREQELFSCSF-PGCSKQYDKACRLKIHLRSHTGERPFICDSDSCGWTFTSMSKLLRHRRKHDDDRRFTCPveg 394
Cdd:COG5048   19 TPKSTLKSLSNAPRPDScPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNS--- 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767927492 395 cgKSFTRAEHLKGHSithlgtKPFECPVEDLLPQLEAPSSLTPSSELSSPgQSELTNMDLaalfsdtpanasgsaggSDE 474
Cdd:COG5048   96 --KSLPLSNSKASSS------SLSSSSSNSNDNNLLSSHSLPPSSRDPQL-PDLLSISNL-----------------RNN 149

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 767927492 475 ALNSGILTIDVTSVSSSLGGNLPANNSSLGPMEPLVLVAHSDIPPSLDSPLVL 527
Cdd:COG5048  150 PLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSNVSTSIPSSSEN 202
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
168-382 1.07e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.01  E-value: 1.07e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767927492 168 SGPSTPGYRCPEPQCALAFAKKHQLKVHL-LTHGGGQGRRPFKCPLEGCGWAFTTSYKLKRHLQSHDKLRPFGCPVGGCG 246
Cdd:COG5048  281 SSEKGFSLPIKSKQCNISFSRSSPLTRHLrSVNHSGESLKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSS 360

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767927492 247 KKFttvyNLKAHMKGHEqeslfkcevcaerfpthaklSSHQRSHFEPERPYKCDFPGCEKTFITVSALFSHNRAHFREQE 326
Cdd:COG5048  361 SKF----SPLLNNEPPQ--------------------SLQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRP 416

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767927492 327 LfSCSFPGCSKQYDKACRLKIHLRSHTGERPFICdsdsCGWTFTSMSKLLRHRRKH 382
Cdd:COG5048  417 Y-NCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC----SILKSFRRDLDLSNHGKD 467
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 240-317 1.70e-06

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 47.03  E-value: 1.70e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767927492  240 CPVGGCGKKFTTVYNLKAHMKGH------EQESLFKCEV--CAERFPTHAKLSSHQRSHFEPERPYKCDfpGCEKTFITV 311
Cdd:pfam15909   2 CSSPGCCLSFPSVRDLAQHLRTHcpptqsLEGKLFRCSAlsCTETFPSMQELVAHSKLHYKPNRYFKCE--NCLLRFRTH 79


                  ....*.
gi 767927492  312 SALFSH 317
Cdd:pfam15909  80 RSLFKH 85
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
316-527 8.55e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.76  E-value: 8.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767927492 316 SHNRAHFREQELFSCSF-PGCSKQYDKACRLKIHLRSHTGERPFICDSDSCGWTFTSMSKLLRHRRKHDDDRRFTCPveg 394
Cdd:COG5048   19 TPKSTLKSLSNAPRPDScPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNS--- 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767927492 395 cgKSFTRAEHLKGHSithlgtKPFECPVEDLLPQLEAPSSLTPSSELSSPgQSELTNMDLaalfsdtpanasgsaggSDE 474
Cdd:COG5048   96 --KSLPLSNSKASSS------SLSSSSSNSNDNNLLSSHSLPPSSRDPQL-PDLLSISNL-----------------RNN 149

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 767927492 475 ALNSGILTIDVTSVSSSLGGNLPANNSSLGPMEPLVLVAHSDIPPSLDSPLVL 527
Cdd:COG5048  150 PLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSNVSTSIPSSSEN 202
zf-H2C2_2 pfam13465
Zinc-finger double domain;
375-401 4.76e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.76e-03
                          10        20
                  ....*....|....*....|....*..
gi 767927492  375 LLRHRRKHDDDRRFTCPVegCGKSFTR 401
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPE--CGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 229-267 6.88e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.38  E-value: 6.88e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 767927492 229 LQSHDKLRPFGCPVggCGKKFTTVYNLKAHMKGHEQESL 267
Cdd:cd20908   17 LIQHQKAKHFKCHI--CHKKLYTAGGLAVHCLQVHKETL 53
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
168-382 1.07e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.01  E-value: 1.07e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767927492 168 SGPSTPGYRCPEPQCALAFAKKHQLKVHL-LTHGGGQGRRPFKCPLEGCGWAFTTSYKLKRHLQSHDKLRPFGCPVGGCG 246
Cdd:COG5048  281 SSEKGFSLPIKSKQCNISFSRSSPLTRHLrSVNHSGESLKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSS 360

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767927492 247 KKFttvyNLKAHMKGHEqeslfkcevcaerfpthaklSSHQRSHFEPERPYKCDFPGCEKTFITVSALFSHNRAHFREQE 326
Cdd:COG5048  361 SKF----SPLLNNEPPQ--------------------SLQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRP 416

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767927492 327 LfSCSFPGCSKQYDKACRLKIHLRSHTGERPFICdsdsCGWTFTSMSKLLRHRRKH 382
Cdd:COG5048  417 Y-NCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC----SILKSFRRDLDLSNHGKD 467
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 240-317 1.70e-06

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 47.03  E-value: 1.70e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767927492  240 CPVGGCGKKFTTVYNLKAHMKGH------EQESLFKCEV--CAERFPTHAKLSSHQRSHFEPERPYKCDfpGCEKTFITV 311
Cdd:pfam15909   2 CSSPGCCLSFPSVRDLAQHLRTHcpptqsLEGKLFRCSAlsCTETFPSMQELVAHSKLHYKPNRYFKCE--NCLLRFRTH 79


                  ....*.
gi 767927492  312 SALFSH 317
Cdd:pfam15909  80 RSLFKH 85
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
284-421 1.39e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.54  E-value: 1.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767927492 284 SSHQRSHFEPER----PYKCdfPGCEKTFITVSALFSHNRA---HFREQELFSCSFPGCSKQYDKACRLKIHLRSHTGER 356
Cdd:COG5048  273 SSPNESDSSSEKgfslPIKS--KQCNISFSRSSPLTRHLRSvnhSGESLKPFSCPYSLCGKLFSRNDALKRHILLHTSIS 350

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767927492 357 PFICDSDSCGWTFTSMS-----KLLRHRRKHDDDRRFTCPVEGCGKSFTRAEHLKGHSITHLGTKPFECP 421
Cdd:COG5048  351 PAKEKLLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCK 420
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 204-260 4.20e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 46.63  E-value: 4.20e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767927492 204 GRRPFKCPLEGCGWAFTTSYKLKRHL---------------QSHD----KLRPFGCPVggCGKKFTTVYNLKAHMK 260
Cdd:COG5189  346 DGKPYKCPVEGCNKKYKNQNGLKYHMlhghqnqklhenpspEKMNifsaKDKPYRCEV--CDKRYKNLNGLKYHRK 419
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 236-291 9.16e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.86  E-value: 9.16e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767927492 236 RPFGCPVGGCGKKFTTVYNLKAHMK-GHEQESL------------------FKCEVCAERFPTHAKLSSHqRSHF 291
Cdd:COG5189  348 KPYKCPVEGCNKKYKNQNGLKYHMLhGHQNQKLhenpspekmnifsakdkpYRCEVCDKRYKNLNGLKYH-RKHS 421
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
316-527 8.55e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.76  E-value: 8.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767927492 316 SHNRAHFREQELFSCSF-PGCSKQYDKACRLKIHLRSHTGERPFICDSDSCGWTFTSMSKLLRHRRKHDDDRRFTCPveg 394
Cdd:COG5048   19 TPKSTLKSLSNAPRPDScPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNS--- 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767927492 395 cgKSFTRAEHLKGHSithlgtKPFECPVEDLLPQLEAPSSLTPSSELSSPgQSELTNMDLaalfsdtpanasgsaggSDE 474
Cdd:COG5048   96 --KSLPLSNSKASSS------SLSSSSSNSNDNNLLSSHSLPPSSRDPQL-PDLLSISNL-----------------RNN 149

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 767927492 475 ALNSGILTIDVTSVSSSLGGNLPANNSSLGPMEPLVLVAHSDIPPSLDSPLVL 527
Cdd:COG5048  150 PLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSNVSTSIPSSSEN 202
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 208-232 1.31e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.51  E-value: 1.31e-03
                          10        20
                  ....*....|....*....|....*
gi 767927492  208 FKCPleGCGWAFTTSYKLKRHLQSH 232
Cdd:pfam00096   1 YKCP--DCGKSFSRKSNLKRHLRTH 23
COG5236 COG5236
Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];
235-461 1.31e-03

Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];


Pssm-ID: 227561 [Multi-domain]  Cd Length: 493  Bit Score: 41.93  E-value: 1.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767927492 235 LRPFGCPVGGCGKKFTTVYNLKAHMKGheQESLFKCEVCAerfpTHAKlsshqrshfeperpykcDFPgCEKTFITVSAL 314
Cdd:COG5236  149 LLSFKCPKSKCHRRCGSLKELKKHYKA--QHGFVLCSECI----GNKK-----------------DFW-NEIRLFRSSTL 204

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767927492 315 FSHNRAHFREqELFS----CSFpgCSKQYDKACRLKIHLRSHTgERPFICD--SDSCGWTFTSMSKLLRHRRKHdddrRF 388
Cdd:COG5236  205 RDHKNGGLEE-EGFKghplCIF--CKIYFYDDDELRRHCRLRH-EACHICDmvGPIRYQYFKSYEDLEAHFRNA----HY 276

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767927492 389 TCPVEGC--GKSFTRAEH--LKGH------SITHLGTKPF--EC--PVEDLLPQLEAPSSLtpSSELSSPGQSELTNMDL 454
Cdd:COG5236  277 CCTFQTCrvGKCYVFPYHteLLEHltrfhkVNARLSEIPRpgRCsiPVMDPFKRKKAPARV--SVIDPSGGNARAPMAHR 354


                 ....*..
gi 767927492 455 AALFSDT 461
Cdd:COG5236  355 GGSRQDT 361
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 177-286 2.14e-03

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 38.17  E-value: 2.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767927492  177 CPEPQCALAFAKKHQLKVHLLTHGggqgrrPFKCPLEGcgwafttsyklkrhlqshdklRPFGCPVGGCGKKFTTVYNLK 256
Cdd:pfam15909   2 CSSPGCCLSFPSVRDLAQHLRTHC------PPTQSLEG---------------------KLFRCSALSCTETFPSMQELV 54

                          90       100       110
                  ....*....|....*....|....*....|.
gi 767927492  257 AHMKGHEQES-LFKCEVCAERFPTHAKLSSH 286
Cdd:pfam15909  55 AHSKLHYKPNrYFKCENCLLRFRTHRSLFKH 85
COG5236 COG5236
Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];
208-335 3.45e-03

Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];


Pssm-ID: 227561 [Multi-domain]  Cd Length: 493  Bit Score: 40.77  E-value: 3.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767927492 208 FKCPLEGCGWAFTTSYKLKRHLQS-HDKLRPFGCpvGGCGKKFT---TVYN---LKAHMKGHEQESLFK----CEVCAER 276
Cdd:COG5236  152 FKCPKSKCHRRCGSLKELKKHYKAqHGFVLCSEC--IGNKKDFWneiRLFRsstLRDHKNGGLEEEGFKghplCIFCKIY 229

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767927492 277 FPTHAKLSSHQRShfEPERPYKCDF--PGCEKTFITVSALFshnrAHFREQElFSCSFPGC 335
Cdd:COG5236  230 FYDDDELRRHCRL--RHEACHICDMvgPIRYQYFKSYEDLE----AHFRNAH-YCCTFQTC 283
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 273-330 3.65e-03

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 37.40  E-value: 3.65e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767927492  273 CAERFPTHAKLSSHQRSHFEPERP-----YKCDFPGCEKTFITVSALFSHNRAHFREQELFSC 330
Cdd:pfam15909   7 CCLSFPSVRDLAQHLRTHCPPTQSlegklFRCSALSCTETFPSMQELVAHSKLHYKPNRYFKC 69
zf-H2C2_2 pfam13465
Zinc-finger double domain;
375-401 4.76e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.76e-03
                          10        20
                  ....*....|....*....|....*..
gi 767927492  375 LLRHRRKHDDDRRFTCPVegCGKSFTR 401
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPE--CGKSFKS 26
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 330-408 5.88e-03

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 37.01  E-value: 5.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767927492  330 CSFPGCSKQYDKACRLKIHLRSHTGE------RPFICDSDSCGWTFTSMSKLLRHRRKH-DDDRRFTCpvEGCGKSFTRA 402
Cdd:pfam15909   2 CSSPGCCLSFPSVRDLAQHLRTHCPPtqslegKLFRCSALSCTETFPSMQELVAHSKLHyKPNRYFKC--ENCLLRFRTH 79


                  ....*.
gi 767927492  403 EHLKGH 408
Cdd:pfam15909  80 RSLFKH 85
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 388-412 6.16e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 6.16e-03
                          10        20
                  ....*....|....*....|....*
gi 767927492  388 FTCPveGCGKSFTRAEHLKGHSITH 412
Cdd:pfam00096   1 YKCP--DCGKSFSRKSNLKRHLRTH 23
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 229-267 6.88e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.38  E-value: 6.88e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 767927492 229 LQSHDKLRPFGCPVggCGKKFTTVYNLKAHMKGHEQESL 267
Cdd:cd20908   17 LIQHQKAKHFKCHI--CHKKLYTAGGLAVHCLQVHKETL 53
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
283-421 7.18e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.68  E-value: 7.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767927492 283 LSSHQRSHFEPERPYKCDFPGCEKTFITVSALFSHNRAHFREqelfSCSFPGCSKQYDKACRLKIHLRSHTGERPF--IC 360
Cdd:COG5048  215 SSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSS----ASESPRSSLPTASSQSSSPNESDSSSEKGFslPI 290

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767927492 361 DSDSCGWTFTSMSKLLRHRRKHDDD----RRFTCPVEGCGKSFTRAEHLKGHSITHLGTKPFECP 421
Cdd:COG5048  291 KSKQCNISFSRSSPLTRHLRSVNHSgeslKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEK 355
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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