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Conserved domains on  [gi|767947841|ref|XP_011514526|]
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muskelin isoform X3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Muskelin_N pfam06588
Muskelin N-terminus; This family represents the N-terminal region of muskelin and is found in ...
 12-207 8.41e-128

Muskelin N-terminus; This family represents the N-terminal region of muskelin and is found in conjunction with several pfam01344 repeats. Muskelin is an intracellular, kelch repeat protein that is needed in cell-spreading responses to the matrix adhesion molecule, thrombospondin-1.


:

Pssm-ID: 284099  Cd Length: 197  Bit Score: 368.76  E-value: 8.41e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947841   12 ECRLLPYALHKWSSFSSTYLPENILVDKPNDQSSRWSSESNYPPQYLILKLERPAIVQNITFGKYEKTHVCNLKKFKVFG 91
Cdd:pfam06588   1 EYSVLPYEIHSYSSYSSVYLPENILVDDPNDQNSRWSTSTNSPPQYLILKLPRPAIVTTITFGKYEKMHVCNLKKFRVYG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947841   92 GMNEENMTELLSSGLKNDYNKETFTLKHKI-DEQMFPCRFIKIVPLLSWGPSFNFSIWYVELSGIDDPDIVQPCLNWYSK 170
Cdd:pfam06588  81 GRDGEEMRELLCGGLKNDSNMETFNLLVKDyNEIYFPCQYIKIVPLLAWGPSFNFSIWYVELHGIDDPSAVSEFVKNYEM 160

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 767947841  171 YREQEAIRLCLKHFRQHNYTEAFESLQKKTKIALEHP 207
Cdd:pfam06588 161 VREGEAIRLCLKHFRQCGYLDIFEILQKRTSDKIEHP 197
NanM super family cl34543
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
248-407 1.99e-08

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


The actual alignment was detected with superfamily member COG3055:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 55.55  E-value: 1.99e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947841 248 KPRWSQIIPKSTKGdgednrpgmRGGHQMVidVQTETVYLFGGWDGTQD----LADFWAYSVKENQWTcisrdtEKENGP 323
Cdd:COG3055   47 TNTWSELAPLPGPP---------RHHAAAV--AQDGKLYVFGGFTGANPsstpLNDVYVYDPATNTWT------KLAPMP 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947841 324 SARSCHKMCIDiqRRQIYTLGRYLDSSVRNskslksDFYRYDIDTNTWMLLSEDTAADggpklvfDHQMCMDSEKHMIYT 403
Cdd:COG3055  110 TPRGGATALLL--DGKIYVVGGWDDGGNVA------WVEVYDPATGTWTQLAPLPTPR-------DHLAAAVLPDGKILV 174


                 ....
gi 767947841 404 FGGR 407
Cdd:COG3055  175 IGGR 178
CTLH smart00668
C-terminal to LisH motif; Alpha-helical motif of unknown function.
 206-258 7.67e-03

C-terminal to LisH motif; Alpha-helical motif of unknown function.


:

Pssm-ID: 128914  Cd Length: 58  Bit Score: 34.85  E-value: 7.67e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 767947841   206 HPMLTDIHDKLVLKGDFDACEELIEKAVNDGL-----FNQYISQQEYKPRWSQIIPKS 258
Cdd:smart00668   1 EFDERKRIRELILKGDWDEALEWLSSLKPPLLernskLEFELRKQKFLELVRQGKLEE 58
 
Name Accession Description Interval E-value
Muskelin_N pfam06588
Muskelin N-terminus; This family represents the N-terminal region of muskelin and is found in ...
 12-207 8.41e-128

Muskelin N-terminus; This family represents the N-terminal region of muskelin and is found in conjunction with several pfam01344 repeats. Muskelin is an intracellular, kelch repeat protein that is needed in cell-spreading responses to the matrix adhesion molecule, thrombospondin-1.


Pssm-ID: 284099  Cd Length: 197  Bit Score: 368.76  E-value: 8.41e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947841   12 ECRLLPYALHKWSSFSSTYLPENILVDKPNDQSSRWSSESNYPPQYLILKLERPAIVQNITFGKYEKTHVCNLKKFKVFG 91
Cdd:pfam06588   1 EYSVLPYEIHSYSSYSSVYLPENILVDDPNDQNSRWSTSTNSPPQYLILKLPRPAIVTTITFGKYEKMHVCNLKKFRVYG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947841   92 GMNEENMTELLSSGLKNDYNKETFTLKHKI-DEQMFPCRFIKIVPLLSWGPSFNFSIWYVELSGIDDPDIVQPCLNWYSK 170
Cdd:pfam06588  81 GRDGEEMRELLCGGLKNDSNMETFNLLVKDyNEIYFPCQYIKIVPLLAWGPSFNFSIWYVELHGIDDPSAVSEFVKNYEM 160

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 767947841  171 YREQEAIRLCLKHFRQHNYTEAFESLQKKTKIALEHP 207
Cdd:pfam06588 161 VREGEAIRLCLKHFRQCGYLDIFEILQKRTSDKIEHP 197
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
248-407 1.99e-08

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 55.55  E-value: 1.99e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947841 248 KPRWSQIIPKSTKGdgednrpgmRGGHQMVidVQTETVYLFGGWDGTQD----LADFWAYSVKENQWTcisrdtEKENGP 323
Cdd:COG3055   47 TNTWSELAPLPGPP---------RHHAAAV--AQDGKLYVFGGFTGANPsstpLNDVYVYDPATNTWT------KLAPMP 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947841 324 SARSCHKMCIDiqRRQIYTLGRYLDSSVRNskslksDFYRYDIDTNTWMLLSEDTAADggpklvfDHQMCMDSEKHMIYT 403
Cdd:COG3055  110 TPRGGATALLL--DGKIYVVGGWDDGGNVA------WVEVYDPATGTWTQLAPLPTPR-------DHLAAAVLPDGKILV 174


                 ....
gi 767947841 404 FGGR 407
Cdd:COG3055  175 IGGR 178
Kelch_3 pfam13415
Galactose oxidase, central domain;
282-334 2.49e-07

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 47.28  E-value: 2.49e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 767947841  282 TETVYLFGGWD--GTQDLADFWAYSVKENQWTCISrdtekeNGPSARSCHKMCID 334
Cdd:pfam13415   1 GDKLYIFGGLGfdGQTRLNDLYVYDLDTNTWTQIG------DLPPPRSGHSATYI 49
PLN02153 PLN02153
epithiospecifier protein
 285-376 2.60e-06

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 49.21  E-value: 2.60e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947841 285 VYLFGGWDGTQDLADFWAYSVKENQWTCISRdTEKENGPSARSCHKMCIDiqRRQIYTLGRYLDSSVRNSKSLKSDFYRY 364
Cdd:PLN02153  88 LYIFGGRDEKREFSDFYSYDTVKNEWTFLTK-LDEEGGPEARTFHSMASD--ENHVYVFGGVSKGGLMKTPERFRTIEAY 164

                         90
                 ....*....|..
gi 767947841 365 DIDTNTWMLLSE 376
Cdd:PLN02153 165 NIADGKWVQLPD 176
Kelch smart00612
Kelch domain;
285-311 8.70e-04

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 37.15  E-value: 8.70e-04
                           10        20
                   ....*....|....*....|....*..
gi 767947841   285 VYLFGGWDGTQDLADFWAYSVKENQWT 311
Cdd:smart00612   2 IYVVGGFDGGQRLKSVEVYDPETNKWT 28
LisH smart00667
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
 172-202 4.87e-03

Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.


Pssm-ID: 128913  Cd Length: 34  Bit Score: 34.72  E-value: 4.87e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 767947841   172 REQEAIRLCLKHFRQHNYTEAFESLQKKTKI 202
Cdd:smart00667   2 SRSELNRLILEYLLRNGYEETAETLQKESGL 32
CTLH smart00668
C-terminal to LisH motif; Alpha-helical motif of unknown function.
 206-258 7.67e-03

C-terminal to LisH motif; Alpha-helical motif of unknown function.


Pssm-ID: 128914  Cd Length: 58  Bit Score: 34.85  E-value: 7.67e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 767947841   206 HPMLTDIHDKLVLKGDFDACEELIEKAVNDGL-----FNQYISQQEYKPRWSQIIPKS 258
Cdd:smart00668   1 EFDERKRIRELILKGDWDEALEWLSSLKPPLLernskLEFELRKQKFLELVRQGKLEE 58
 
Name Accession Description Interval E-value
Muskelin_N pfam06588
Muskelin N-terminus; This family represents the N-terminal region of muskelin and is found in ...
 12-207 8.41e-128

Muskelin N-terminus; This family represents the N-terminal region of muskelin and is found in conjunction with several pfam01344 repeats. Muskelin is an intracellular, kelch repeat protein that is needed in cell-spreading responses to the matrix adhesion molecule, thrombospondin-1.


Pssm-ID: 284099  Cd Length: 197  Bit Score: 368.76  E-value: 8.41e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947841   12 ECRLLPYALHKWSSFSSTYLPENILVDKPNDQSSRWSSESNYPPQYLILKLERPAIVQNITFGKYEKTHVCNLKKFKVFG 91
Cdd:pfam06588   1 EYSVLPYEIHSYSSYSSVYLPENILVDDPNDQNSRWSTSTNSPPQYLILKLPRPAIVTTITFGKYEKMHVCNLKKFRVYG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947841   92 GMNEENMTELLSSGLKNDYNKETFTLKHKI-DEQMFPCRFIKIVPLLSWGPSFNFSIWYVELSGIDDPDIVQPCLNWYSK 170
Cdd:pfam06588  81 GRDGEEMRELLCGGLKNDSNMETFNLLVKDyNEIYFPCQYIKIVPLLAWGPSFNFSIWYVELHGIDDPSAVSEFVKNYEM 160

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 767947841  171 YREQEAIRLCLKHFRQHNYTEAFESLQKKTKIALEHP 207
Cdd:pfam06588 161 VREGEAIRLCLKHFRQCGYLDIFEILQKRTSDKIEHP 197
F5_F8_type_C pfam00754
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
 24-152 7.81e-09

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.


Pssm-ID: 459925 [Multi-domain]  Cd Length: 127  Bit Score: 53.61  E-value: 7.81e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947841   24 SSFSSTYLPENiLVDkpNDQSSRWSSESNYPPQYLILKLERPAIVQNITFGKYEKTHVCNLKKFKVFGGMNEENMTELLS 103
Cdd:pfam00754   6 SSYSGEGPAAA-ALD--GDPNTAWSAWSGDDPQWIQVDLGKPKKITGVVTQGRQDGSNGYVTSYKIEYSLDGENWTTVKD 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 767947841  104 SGLKNDYNKETftlkhkIDEQMFPC----RFIKIVPlLSWGPSFNFSIWyVEL 152
Cdd:pfam00754  83 EKIPGNNDNNT------PVTNTFDPpikaRYVRIVP-TSWNGGNGIALR-AEL 127
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
248-407 1.99e-08

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 55.55  E-value: 1.99e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947841 248 KPRWSQIIPKSTKGdgednrpgmRGGHQMVidVQTETVYLFGGWDGTQD----LADFWAYSVKENQWTcisrdtEKENGP 323
Cdd:COG3055   47 TNTWSELAPLPGPP---------RHHAAAV--AQDGKLYVFGGFTGANPsstpLNDVYVYDPATNTWT------KLAPMP 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947841 324 SARSCHKMCIDiqRRQIYTLGRYLDSSVRNskslksDFYRYDIDTNTWMLLSEDTAADggpklvfDHQMCMDSEKHMIYT 403
Cdd:COG3055  110 TPRGGATALLL--DGKIYVVGGWDDGGNVA------WVEVYDPATGTWTQLAPLPTPR-------DHLAAAVLPDGKILV 174


                 ....
gi 767947841 404 FGGR 407
Cdd:COG3055  175 IGGR 178
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
284-407 1.94e-07

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 52.47  E-value: 1.94e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947841 284 TVYLFGGWDGTQDLADFWAYSVKENQWtcisrdTEKENGPSARSCHKMCIdIQRRQIYTLGRYldSSVRNSKSLKSDFYR 363
Cdd:COG3055   24 KVYVAGGLSGGSASNSFEVYDPATNTW------SELAPLPGPPRHHAAAV-AQDGKLYVFGGF--TGANPSSTPLNDVYV 94

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 767947841 364 YDIDTNTWmllsedTAADGGPKLVFDHQMCMDSEKhmIYTFGGR 407
Cdd:COG3055   95 YDPATNTW------TKLAPMPTPRGGATALLLDGK--IYVVGGW 130
Kelch_3 pfam13415
Galactose oxidase, central domain;
282-334 2.49e-07

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 47.28  E-value: 2.49e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 767947841  282 TETVYLFGGWD--GTQDLADFWAYSVKENQWTCISrdtekeNGPSARSCHKMCID 334
Cdd:pfam13415   1 GDKLYIFGGLGfdGQTRLNDLYVYDLDTNTWTQIG------DLPPPRSGHSATYI 49
PLN02153 PLN02153
epithiospecifier protein
 285-376 2.60e-06

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 49.21  E-value: 2.60e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947841 285 VYLFGGWDGTQDLADFWAYSVKENQWTCISRdTEKENGPSARSCHKMCIDiqRRQIYTLGRYLDSSVRNSKSLKSDFYRY 364
Cdd:PLN02153  88 LYIFGGRDEKREFSDFYSYDTVKNEWTFLTK-LDEEGGPEARTFHSMASD--ENHVYVFGGVSKGGLMKTPERFRTIEAY 164

                         90
                 ....*....|..
gi 767947841 365 DIDTNTWMLLSE 376
Cdd:PLN02153 165 NIADGKWVQLPD 176
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 270-314 3.89e-06

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 43.75  E-value: 3.89e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 767947841  270 MRGGHQMVidVQTETVYLFGGWDGTQDLADFWAYSVKENQWTCIS 314
Cdd:pfam01344   1 RRSGAGVV--VVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLP 43
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
268-422 1.58e-05

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 46.69  E-value: 1.58e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947841 268 PGMRGGHQMVidVQTETVYLFGGWDGTQDLADFWAYSVKENQWTCIS-----RD-------------------------- 316
Cdd:COG3055  109 PTPRGGATAL--LLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAplptpRDhlaaavlpdgkilviggrngsgfsnt 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947841 317 -TEKENGPSARSCHKMCIDIQRrqIYTLGRYLDSSvrnskslkSDFYRYDIDTNTWMLLSEDTAADGGPKLVfdhqmcmd 395
Cdd:COG3055  187 wTTLAPLPTARAGHAAAVLGGK--ILVFGGESGFS--------DEVEAYDPATNTWTALGELPTPRHGHAAV-------- 248

                        170       180
                 ....*....|....*....|....*..
gi 767947841 396 sekhmiyTFGGRILTCNGSVDDSRASE 422
Cdd:COG3055  249 -------LTDGKVYVIGGETKPGVRTP 268
PLN02193 PLN02193
nitrile-specifier protein
 284-386 5.92e-05

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 45.33  E-value: 5.92e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947841 284 TVYLFGGWDGTQDLADFWAYSVKENQWTCIsrdTEKENGPSARSCHKMCIDiqRRQIYTLGRYldSSVRNSKSLKSdfyr 363
Cdd:PLN02193 230 TLYVFGGRDASRQYNGFYSFDTTTNEWKLL---TPVEEGPTPRSFHSMAAD--EENVYVFGGV--SATARLKTLDS---- 298

                         90       100
                 ....*....|....*....|....*.
gi 767947841 364 YDIDTNTWMLLS---EDTAADGGPKL 386
Cdd:PLN02193 299 YNIVDKKWFHCStpgDSFSIRGGAGL 324
PLN02153 PLN02153
epithiospecifier protein
 307-461 1.17e-04

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 44.21  E-value: 1.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947841 307 ENQWtcISRDTEKENGPSARSCHKMCIdiQRRQIYTLGryldSSVRNSKSLKSDFYRYDIDTNTWMLlsedTAADGGPKL 386
Cdd:PLN02153   6 QGGW--IKVEQKGGKGPGPRCSHGIAV--VGDKLYSFG----GELKPNEHIDKDLYVFDFNTHTWSI----APANGDVPR 73

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767947841 387 VFDHQMCMDSEKHMIYTFGGRiltcngsvDDSRAsepqFSGLFAFNCQCQTWKLLREDSCNAGPEdiqSRIGHCM 461
Cdd:PLN02153  74 ISCLGVRMVAVGTKLYIFGGR--------DEKRE----FSDFYSYDTVKNEWTFLTKLDEEGGPE---ARTFHSM 133
PLN02193 PLN02193
nitrile-specifier protein
 318-441 2.79e-04

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 43.41  E-value: 2.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947841 318 EKENGPSARSCHkmciDIQR--RQIYTLGRYLDSSVRNSKSLksdfYRYDIDTNTWMLlsedTAADGGPKLVFDHQMCMD 395
Cdd:PLN02193 158 QKGEGPGLRCSH----GIAQvgNKIYSFGGEFTPNQPIDKHL----YVFDLETRTWSI----SPATGDVPHLSCLGVRMV 225

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 767947841 396 SEKHMIYTFGGRiltcngsvDDSRasepQFSGLFAFNCQCQTWKLL 441
Cdd:PLN02193 226 SIGSTLYVFGGR--------DASR----QYNGFYSFDTTTNEWKLL 259
Kelch_4 pfam13418
Galactose oxidase, central domain;
271-314 3.19e-04

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 38.36  E-value: 3.19e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 767947841  271 RGGHQMVIdVQTETVYLFGG--WDGTQdLADFWAYSVKENQWTCIS 314
Cdd:pfam13418   2 RAYHTSTS-IPDDTIYLFGGegEDGTL-LSDLWVFDLSTNEWTRLG 45
Kelch smart00612
Kelch domain;
285-311 8.70e-04

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 37.15  E-value: 8.70e-04
                           10        20
                   ....*....|....*....|....*..
gi 767947841   285 VYLFGGWDGTQDLADFWAYSVKENQWT 311
Cdd:smart00612   2 IYVVGGFDGGQRLKSVEVYDPETNKWT 28
LisH smart00667
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
 172-202 4.87e-03

Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.


Pssm-ID: 128913  Cd Length: 34  Bit Score: 34.72  E-value: 4.87e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 767947841   172 REQEAIRLCLKHFRQHNYTEAFESLQKKTKI 202
Cdd:smart00667   2 SRSELNRLILEYLLRNGYEETAETLQKESGL 32
CTLH smart00668
C-terminal to LisH motif; Alpha-helical motif of unknown function.
 206-258 7.67e-03

C-terminal to LisH motif; Alpha-helical motif of unknown function.


Pssm-ID: 128914  Cd Length: 58  Bit Score: 34.85  E-value: 7.67e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 767947841   206 HPMLTDIHDKLVLKGDFDACEELIEKAVNDGL-----FNQYISQQEYKPRWSQIIPKS 258
Cdd:smart00668   1 EFDERKRIRELILKGDWDEALEWLSSLKPPLLernskLEFELRKQKFLELVRQGKLEE 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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