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Conserved domains on  [gi|767952748|ref|XP_011515241|]
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DENN domain-containing protein 3 isoform X19 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 518-619 3.67e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 52.72  E-value: 3.67e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767952748 518 HSFKVGTAKVNCMVMADQNQ-VWVGSEDSVIYIINVHSMSCNKQLTAHCSSVTDLI-VQDGQEapsnVYSCSMDGMVLVW 595
Cdd:cd00200    3 RTLKGHTGGVTCVAFSPDGKlLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAaSADGTY----LASGSSDKTIRLW 78

                         90       100
                 ....*....|....*....|....
gi 767952748 596 NVSTLQVTSRFQLPRGGLTSIRLH 619
Cdd:cd00200   79 DLETGECVRTLTGHTSYVSSVAFS 102
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 518-619 3.67e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 52.72  E-value: 3.67e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767952748 518 HSFKVGTAKVNCMVMADQNQ-VWVGSEDSVIYIINVHSMSCNKQLTAHCSSVTDLI-VQDGQEapsnVYSCSMDGMVLVW 595
Cdd:cd00200    3 RTLKGHTGGVTCVAFSPDGKlLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAaSADGTY----LASGSSDKTIRLW 78

                         90       100
                 ....*....|....*....|....
gi 767952748 596 NVSTLQVTSRFQLPRGGLTSIRLH 619
Cdd:cd00200   79 DLETGECVRTLTGHTSYVSSVAFS 102
WD40 COG2319
WD40 repeat [General function prediction only];
503-616 5.07e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 49.52  E-value: 5.07e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767952748 503 GKVTVFNASSWTIhQHSFKVGTAKVNCMVMA-DQNQVWVGSEDSVIYIINVHSMSCNKQLTAHCSSVTDL-IVQDGQEap 580
Cdd:COG2319  268 GTVRLWDLATGEL-LRTLTGHSGGVNSVAFSpDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVaFSPDGKT-- 344

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 767952748 581 snVYSCSMDGMVLVWNVSTLQVTSRFQLPRGGLTSI 616
Cdd:COG2319  345 --LASGSDDGTVRLWDLATGELLRTLTGHTGAVTSV 378
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 518-619 3.67e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 52.72  E-value: 3.67e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767952748 518 HSFKVGTAKVNCMVMADQNQ-VWVGSEDSVIYIINVHSMSCNKQLTAHCSSVTDLI-VQDGQEapsnVYSCSMDGMVLVW 595
Cdd:cd00200    3 RTLKGHTGGVTCVAFSPDGKlLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAaSADGTY----LASGSSDKTIRLW 78

                         90       100
                 ....*....|....*....|....
gi 767952748 596 NVSTLQVTSRFQLPRGGLTSIRLH 619
Cdd:cd00200   79 DLETGECVRTLTGHTSYVSSVAFS 102
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 481-685 1.26e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.80  E-value: 1.26e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767952748 481 GHLDPAEKVE--DAHPKLWCALSEGKVTVFNASS----WTIHQHsfkvgTAKVNCMVMADQNQVWVGS-EDSVIYIINVH 553
Cdd:cd00200   49 GHTGPVRDVAasADGTYLASGSSDKTIRLWDLETgecvRTLTGH-----TSYVSSVAFSPDGRILSSSsRDKTIKVWDVE 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767952748 554 SMSCNKQLTAHCSSVTDLIVQdgqeaPSN--VYSCSMDGMVLVWNVSTLQVTSRFQLPRGGLTSIRLHGGRLWCCTGNSI 631
Cdd:cd00200  124 TGKCLTTLRGHTDWVNSVAFS-----PDGtfVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSD 198

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 767952748 632 MVMKM----NGSLHQELKIEENFkdtstsflAFQLLPEEEQLWAACAGR-SEVYIWSLK 685
Cdd:cd00200  199 GTIKLwdlsTGKCLGTLRGHENG--------VNSVAFSPDGYLLASGSEdGTIRVWDLR 249
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 480-633 3.17e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 49.64  E-value: 3.17e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767952748 480 PGHLDPAEKVeDAHPK---LWCALSEGKVTVFNASSW----TIHQHsfkvgTAKVNCM-VMADQNQVWVGSEDSVIYIIN 551
Cdd:cd00200  132 RGHTDWVNSV-AFSPDgtfVASSSQDGTIKLWDLRTGkcvaTLTGH-----TGEVNSVaFSPDGEKLLSSSSDGTIKLWD 205

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767952748 552 VHSMSCNKQLTAHCSSVTDLIVqdgqeAPSN--VYSCSMDGMVLVWNVSTLQVTSRFQLPRGGLTSIRLHGGRLWCCTG- 628
Cdd:cd00200  206 LSTGKCLGTLRGHENGVNSVAF-----SPDGylLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGs 280


                 ....*..
gi 767952748 629 --NSIMV 633
Cdd:cd00200  281 adGTIRI 287
WD40 COG2319
WD40 repeat [General function prediction only];
503-616 5.07e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 49.52  E-value: 5.07e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767952748 503 GKVTVFNASSWTIhQHSFKVGTAKVNCMVMA-DQNQVWVGSEDSVIYIINVHSMSCNKQLTAHCSSVTDL-IVQDGQEap 580
Cdd:COG2319  268 GTVRLWDLATGEL-LRTLTGHSGGVNSVAFSpDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVaFSPDGKT-- 344

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 767952748 581 snVYSCSMDGMVLVWNVSTLQVTSRFQLPRGGLTSI 616
Cdd:COG2319  345 --LASGSDDGTVRLWDLATGELLRTLTGHTGAVTSV 378
WD40 COG2319
WD40 repeat [General function prediction only];
503-619 1.32e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 48.37  E-value: 1.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767952748 503 GKVTVFNASSWTIhQHSFKVGTAKVNCMVMA-DQNQVWVGSEDSVIYIINVHSMSCNKQLTAHCSSVTDLIV-QDGQEap 580
Cdd:COG2319  184 GTVRLWDLATGKL-LRTLTGHTGAVRSVAFSpDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFsPDGRL-- 260

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 767952748 581 snVYSCSMDGMVLVWNVSTLQVTSRFQLPRGGLTSIRLH 619
Cdd:COG2319  261 --LASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFS 297
WD40 COG2319
WD40 repeat [General function prediction only];
496-686 1.32e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 48.37  E-value: 1.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767952748 496 LWCALSEGKVTVFNASSWTIhQHSFKVGTAKVNCMVMA-DQNQVWVGSEDSVIYIINVHSMSCNKQLTAHCSSVTDL-IV 573
Cdd:COG2319  219 LASGSADGTVRLWDLATGKL-LRTLTGHSGSVRSVAFSpDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVaFS 297

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767952748 574 QDGQeapsNVYSCSMDGMVLVWNVSTLQVTSRFQLPRGGLTSIRLH--GGRL-WCCTGNSIMVMKMNGSlhQELKIEENF 650
Cdd:COG2319  298 PDGK----LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSpdGKTLaSGSDDGTVRLWDLATG--ELLRTLTGH 371

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 767952748 651 KDTSTSfLAFqlLPEEEQLWAACAGRSeVYIWSLKD 686
Cdd:COG2319  372 TGAVTS-VAF--SPDGRTLASGSADGT-VRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 501-596 1.68e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 47.33  E-value: 1.68e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767952748 501 SEGKVTVFNASSWTiHQHSFKVGTAKVNCmVMADQNQVWV--GSEDSVIYIINVHSMSCNKQLTAHCSSVTDL-IVQDGQ 577
Cdd:cd00200  197 SDGTIKLWDLSTGK-CLGTLRGHENGVNS-VAFSPDGYLLasGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLaWSPDGK 274

                         90
                 ....*....|....*....
gi 767952748 578 EapsnVYSCSMDGMVLVWN 596
Cdd:cd00200  275 R----LASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
503-619 2.17e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 47.60  E-value: 2.17e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767952748 503 GKVTVFNASSWTIhQHSFKVGTAKVNCMVM-ADQNQVWVGSEDSVIYIINVHSMSCNKQLTAHCSSVTDLIV-QDGQeap 580
Cdd:COG2319  142 GTVRLWDLATGKL-LRTLTGHSGAVTSVAFsPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFsPDGK--- 217

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 767952748 581 sNVYSCSMDGMVLVWNVSTLQVTSRFQLPRGGLTSIRLH 619
Cdd:COG2319  218 -LLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFS 255
WD40 COG2319
WD40 repeat [General function prediction only];
499-616 3.84e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 43.75  E-value: 3.84e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767952748 499 ALSEGKVTVFNASSwTIHQHSFKVGTAKVNCMVM-ADQNQVWVGSEDSVIYIINVHSMSCNKQLTAHCSSVTDLIV-QDG 576
Cdd:COG2319   96 ASADGTVRLWDLAT-GLLLRTLTGHTGAVRSVAFsPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFsPDG 174

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 767952748 577 QeapsNVYSCSMDGMVLVWNVSTLQVTSRFQLPRGGLTSI 616
Cdd:COG2319  175 K----LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV 210
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 557-631 3.34e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 40.40  E-value: 3.34e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767952748 557 CNKQLTAHCSSVTDLIVQDGQEapsNVYSCSMDGMVLVWNVSTLQVTSRFQLPRGGLTSIrlhggrLWCCTGNSI 631
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGK---LLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDV------AASADGTYL 66
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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