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Conserved domains on  [gi|767952769|ref|XP_011515249|]
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zinc finger protein ZFPM2 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PR-SET_ZFPM2 cd19216
PR-SET domain found in zinc finger protein ZFPM2 and similar proteins; ZFPM2 (also termed ...
 87-197 1.20e-74

PR-SET domain found in zinc finger protein ZFPM2 and similar proteins; ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


:

Pssm-ID: 380993  Cd Length: 111  Bit Score: 241.71  E-value: 1.20e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767952769   87 WDGPGELEVFQKDGERKIQSRQQLPVGTTWGPFPGKMDLNNNSLKTKAQVPMVLTAGPKWLLDVTWQGVEDNKNNCIVYS 166
Cdd:cd19216     1 WDGPGELEVFQKDGERKIHSRQQLPVGTTWGPFPGKIDLNNNSLKTKAPVPLVLTAGPKWLLDVTWQGTEDNKNNCIVYS 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 767952769  167 KGGQLWCTTTKAISEGEELIAFVVDFDSRLQ 197
Cdd:cd19216    81 KGGQLWCTTTKNISEGEELIAFVVDFDSRLQ 111
 
Name Accession Description Interval E-value
PR-SET_ZFPM2 cd19216
PR-SET domain found in zinc finger protein ZFPM2 and similar proteins; ZFPM2 (also termed ...
 87-197 1.20e-74

PR-SET domain found in zinc finger protein ZFPM2 and similar proteins; ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380993  Cd Length: 111  Bit Score: 241.71  E-value: 1.20e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767952769   87 WDGPGELEVFQKDGERKIQSRQQLPVGTTWGPFPGKMDLNNNSLKTKAQVPMVLTAGPKWLLDVTWQGVEDNKNNCIVYS 166
Cdd:cd19216     1 WDGPGELEVFQKDGERKIHSRQQLPVGTTWGPFPGKIDLNNNSLKTKAPVPLVLTAGPKWLLDVTWQGTEDNKNNCIVYS 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 767952769  167 KGGQLWCTTTKAISEGEELIAFVVDFDSRLQ 197
Cdd:cd19216    81 KGGQLWCTTTKNISEGEELIAFVVDFDSRLQ 111
 
Name Accession Description Interval E-value
PR-SET_ZFPM2 cd19216
PR-SET domain found in zinc finger protein ZFPM2 and similar proteins; ZFPM2 (also termed ...
 87-197 1.20e-74

PR-SET domain found in zinc finger protein ZFPM2 and similar proteins; ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380993  Cd Length: 111  Bit Score: 241.71  E-value: 1.20e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767952769   87 WDGPGELEVFQKDGERKIQSRQQLPVGTTWGPFPGKMDLNNNSLKTKAQVPMVLTAGPKWLLDVTWQGVEDNKNNCIVYS 166
Cdd:cd19216     1 WDGPGELEVFQKDGERKIHSRQQLPVGTTWGPFPGKIDLNNNSLKTKAPVPLVLTAGPKWLLDVTWQGTEDNKNNCIVYS 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 767952769  167 KGGQLWCTTTKAISEGEELIAFVVDFDSRLQ 197
Cdd:cd19216    81 KGGQLWCTTTKNISEGEELIAFVVDFDSRLQ 111
PR-SET_ZFPM cd19201
PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also ...
 87-194 1.10e-29

PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380978  Cd Length: 122  Bit Score: 114.36  E-value: 1.10e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767952769   87 WDGPGELEVFQKDG----ERKIQSRQQLPVGTTWGPFPGKMDLNNNSLKTKAQV-----------PMVLTAGPKWLLDVT 151
Cdd:cd19201     1 LSLPGELELRKPSQdagrSGGVWAKQPLPEGTRFGPYPGKLVKEPLDPSYEWKVeaqgskggeglLLLTEDSGTWLKLVR 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 767952769  152 WQGvEDNKNNCIVYSKGGQLWCTTTKAISEGEELIAFVVDFDS 194
Cdd:cd19201    81 SAD-DEDEANLILYFKGGQIWCEVTKDIPPGEELILVLREPLL 122
PR-SET_ZFPM1 cd19215
PR-SET domain found in zinc finger protein ZFPM1 and similar proteins; ZFPM1 (also termed ...
 87-190 8.27e-22

PR-SET domain found in zinc finger protein ZFPM1 and similar proteins; ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation.


Pssm-ID: 380992  Cd Length: 110  Bit Score: 91.38  E-value: 8.27e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767952769   87 WDGPGELEVFQKDGERKIQSRQQLPVGTTWGPFPGKMDLNNNSLKTKAQ---VPMVLTAGPKWLLDVTwQGVEDNKNNCI 163
Cdd:cd19215     1 WNGPDELELVGSSGQRRVRARQSLSEGLSWGPYHGSIQSSASSPGQAEEspaVTLLLVDEDCWLRRLP-LVSTEAEANCT 79

                          90       100
                  ....*....|....*....|....*..
gi 767952769  164 VYSKGGQLWCTTTKAISEGEELIAFVV 190
Cdd:cd19215    80 IYRKGDAIWCKTTKPVPEGELLSAILV 106
PR-SET_PRDM-like cd10534
PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family ...
 90-188 2.33e-06

PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family of proteins is defined based on the conserved N-terminal PR domain, which is closely related to the Su(var)3-9, enhancer of zeste, and trithorax (SET) domains of histone methyltransferases, and is specifically called PR-SET domain. The family consists of 17 members in primates. PRDMs play diverse roles in cell-cycle regulation, differentiation, and meiotic recombination. The family also contains zinc finger protein ZFPM1 and ZFPM2. ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380932  Cd Length: 83  Bit Score: 46.42  E-value: 2.33e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767952769   90 PGELEVFQ---KDGERKIQSRQQLPVGTTWGPFPGK---MDLNNNSLKTKAQvpmvltagpkwlldvtwqgvednknNCI 163
Cdd:cd10534     2 PAGLELVLssiPEGGLGVFARRTIPAGTRFGPLEGVvnwMRFVRPARNEEEQ-------------------------NLV 56

                          90       100
                  ....*....|....*....|....*
gi 767952769  164 VYSKGGQLWCTTTKAISEGEELIAF 188
Cdd:cd10534    57 AYQHGGQIYFRTTRDIPPGEELLVW 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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