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Conserved domains on  [gi|767952949|ref|XP_011515319|]
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zinc finger protein 517 isoform X1 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
265-437 6.75e-07

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.62  E-value: 6.75e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767952949 265 KPFACTECGKAFCRRFTLNEH--GRIHSGE--RPYRC--LRCGQRFIRGSSLLKHHRLHAqegaqdggvgqgallgaaqr 338
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHT-------------------- 347

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767952949 339 pqaGDPPHECPVCGRPFRHNSLLLLHLRLHT-------GEKPFECA--ECGKAFGRKSNLTLHQKIHTKEKP--FACTEC 407
Cdd:COG5048  348 ---SISPAKEKLLNSSSKFSPLLNNEPPQSLqqykdlkNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPC 424

                        170       180       190
                 ....*....|....*....|....*....|
gi 767952949 408 GKAFRRSYTLNEHYRLHSGERPYRCRACGR 437
Cdd:COG5048  425 SKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
181-320 1.42e-06

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.46  E-value: 1.42e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767952949 181 KPFQCTECGKAFKQSSILLRHQ--LIHTEE--KPFQCGE--CGKAFRQSTQLAAHHRVHTRERPYAC--GECGKAFSRSS 252
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767952949 253 RLLQHQKFH-----TGEKPFACT--ECGKAFCRRFTLNEHGRIHSGERP--YRCLRCGQRFIRgSSLLKHHRLHAQE 320
Cdd:COG5048  368 NNEPPQSLQqykdlKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNR-HYNLIPHKKIHTN 443
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
265-437 6.75e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.62  E-value: 6.75e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767952949 265 KPFACTECGKAFCRRFTLNEH--GRIHSGE--RPYRC--LRCGQRFIRGSSLLKHHRLHAqegaqdggvgqgallgaaqr 338
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHT-------------------- 347

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767952949 339 pqaGDPPHECPVCGRPFRHNSLLLLHLRLHT-------GEKPFECA--ECGKAFGRKSNLTLHQKIHTKEKP--FACTEC 407
Cdd:COG5048  348 ---SISPAKEKLLNSSSKFSPLLNNEPPQSLqqykdlkNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPC 424

                        170       180       190
                 ....*....|....*....|....*....|
gi 767952949 408 GKAFRRSYTLNEHYRLHSGERPYRCRACGR 437
Cdd:COG5048  425 SKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
181-320 1.42e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.46  E-value: 1.42e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767952949 181 KPFQCTECGKAFKQSSILLRHQ--LIHTEE--KPFQCGE--CGKAFRQSTQLAAHHRVHTRERPYAC--GECGKAFSRSS 252
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767952949 253 RLLQHQKFH-----TGEKPFACT--ECGKAFCRRFTLNEHGRIHSGERP--YRCLRCGQRFIRgSSLLKHHRLHAQE 320
Cdd:COG5048  368 NNEPPQSLQqykdlKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNR-HYNLIPHKKIHTN 443
zf-H2C2_2 pfam13465
Zinc-finger double domain;
170-194 2.98e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 2.98e-04
                          10        20
                  ....*....|....*....|....*
gi 767952949  170 LLRHQIIHTGAKPFQCTECGKAFKQ 194
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 374-396 3.29e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 3.29e-03
                          10        20
                  ....*....|....*....|...
gi 767952949  374 FECAECGKAFGRKSNLTLHQKIH 396
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
265-437 6.75e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.62  E-value: 6.75e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767952949 265 KPFACTECGKAFCRRFTLNEH--GRIHSGE--RPYRC--LRCGQRFIRGSSLLKHHRLHAqegaqdggvgqgallgaaqr 338
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHT-------------------- 347

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767952949 339 pqaGDPPHECPVCGRPFRHNSLLLLHLRLHT-------GEKPFECA--ECGKAFGRKSNLTLHQKIHTKEKP--FACTEC 407
Cdd:COG5048  348 ---SISPAKEKLLNSSSKFSPLLNNEPPQSLqqykdlkNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPC 424

                        170       180       190
                 ....*....|....*....|....*....|
gi 767952949 408 GKAFRRSYTLNEHYRLHSGERPYRCRACGR 437
Cdd:COG5048  425 SKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
181-320 1.42e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.46  E-value: 1.42e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767952949 181 KPFQCTECGKAFKQSSILLRHQ--LIHTEE--KPFQCGE--CGKAFRQSTQLAAHHRVHTRERPYAC--GECGKAFSRSS 252
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767952949 253 RLLQHQKFH-----TGEKPFACT--ECGKAFCRRFTLNEHGRIHSGERP--YRCLRCGQRFIRgSSLLKHHRLHAQE 320
Cdd:COG5048  368 NNEPPQSLQqykdlKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNR-HYNLIPHKKIHTN 443
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
160-437 3.65e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.31  E-value: 3.65e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767952949 160 CGKAFRYNSLLLRHQIIHTGAKPFQCT--ECGKAFKQSSILLRHQLIHTEEKPFqcgECGKAFRQSTQLAAHH--RVHTR 235
Cdd:COG5048   39 CTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSD---LNSKSLPLSNSKASSSslSSSSS 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767952949 236 ERPYACGECGKAFSRSSRLLQHQKFHTGEKPFAC---------TECGKAFCRRFTLNE---------------HGRIHSG 291
Cdd:COG5048  116 NSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNplpgnnsssVNTPQSNSLHPPLPAnslskdpssnlslliSSNVSTS 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767952949 292 ERPYRCLRCGQRFIRGSSLLKHHRLHAQEGAQDGGVGQGALLG--AAQRPQAGDPPHECPVCG----------RPFRHNS 359
Cdd:COG5048  196 IPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKslLSQSPSSLSSSDSSSSASesprsslptaSSQSSSP 275

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767952949 360 LLLLHLRLHTGEKPFECAECGKAFGRKSNLTLHQ--KIHTKE--KPFACTE--CGKAFRRSYTLNEHYRLHSGERPYRCR 433
Cdd:COG5048  276 NESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEK 355


                 ....
gi 767952949 434 ACGR 437
Cdd:COG5048  356 LLNS 359
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
160-287 4.95e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.92  E-value: 4.95e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767952949 160 CGKAFRYNSLLLRHQIIHTGAKPFQC--TECGKAFKQSSILLRHQLIH-----TEEKPFQC--GECGKAFRQSTQLAAHH 230
Cdd:COG5048  329 CGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHI 408

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 767952949 231 RVHTRERPYAC--GECGKAFSRSSRLLQHQKFHTgEKPFACTECGKAFCRRFTLNEHGR 287
Cdd:COG5048  409 ITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
170-194 2.98e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 2.98e-04
                          10        20
                  ....*....|....*....|....*
gi 767952949  170 LLRHQIIHTGAKPFQCTECGKAFKQ 194
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
253-276 3.10e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.10e-04
                          10        20
                  ....*....|....*....|....
gi 767952949  253 RLLQHQKFHTGEKPFACTECGKAF 276
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
372-437 6.04e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 6.04e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767952949 372 KPFECAECGKAFGRKSNLTLHQKIHTKEKPFACT--ECGKAFRRSYTLNEHYRLHSGERPYRCRACGR 437
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLP 99
zf-H2C2_2 pfam13465
Zinc-finger double domain;
198-222 8.85e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 8.85e-04
                          10        20
                  ....*....|....*....|....*
gi 767952949  198 LLRHQLIHTEEKPFQCGECGKAFRQ 222
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
237-297 2.01e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.45  E-value: 2.01e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767952949 237 RPYACGECGKAFSRSSRLLQHQKFHTGEKPFACT--ECGKAFCRRFTLNEHGRIHSGERPYRC 297
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLN 94
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 374-396 3.29e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 3.29e-03
                          10        20
                  ....*....|....*....|...
gi 767952949  374 FECAECGKAFGRKSNLTLHQKIH 396
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 211-233 4.08e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 4.08e-03
                          10        20
                  ....*....|....*....|...
gi 767952949  211 FQCGECGKAFRQSTQLAAHHRVH 233
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 402-424 8.94e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 8.94e-03
                          10        20
                  ....*....|....*....|...
gi 767952949  402 FACTECGKAFRRSYTLNEHYRLH 424
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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