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Conserved domains on  [gi|767953412|ref|XP_011515516|]
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maestro heat-like repeat-containing protein family member 6 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 637-741 2.78e-03

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 2.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953412  637 ATCPGGSPGTPAPGFSSAASSALRISPPVLPLALLSPGSAI------PRPRAQLPEPDPGLPAESTGPPAPGSRRAYRLP 710
Cdd:PHA03247 2855 SVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTesfalpPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPP 2934

                          90       100       110
                  ....*....|....*....|....*....|.
gi 767953412  711 CPPRQPRLCQPGPAGLPVPGPRATAERPQAG 741
Cdd:PHA03247 2935 PPPRPQPPLAPTTDPAGAGEPSGAVPQPWLG 2965
 
Name Accession Description Interval E-value
PHA03247 PHA03247
large tegument protein UL36; Provisional
 637-741 2.78e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 2.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953412  637 ATCPGGSPGTPAPGFSSAASSALRISPPVLPLALLSPGSAI------PRPRAQLPEPDPGLPAESTGPPAPGSRRAYRLP 710
Cdd:PHA03247 2855 SVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTesfalpPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPP 2934

                          90       100       110
                  ....*....|....*....|....*....|.
gi 767953412  711 CPPRQPRLCQPGPAGLPVPGPRATAERPQAG 741
Cdd:PHA03247 2935 PPPRPQPPLAPTTDPAGAGEPSGAVPQPWLG 2965
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 637-731 9.04e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 39.75  E-value: 9.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953412  637 ATCPGGSPGTPAPGFSSAASSALRISPPVLPLALLSPGSAIPRPRaqLPEPDPGLpAESTGPPAPGSRRAYRLPCP---- 712
Cdd:pfam03154 197 AGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQR--LPSPHPPL-QPMTQPPPPSQVSPQPLPQPslhg 273

                          90       100
                  ....*....|....*....|.
gi 767953412  713 --PRQPRLCQPGPAGLPVPGP 731
Cdd:pfam03154 274 qmPPMPHSLQTGPSHMQHPVP 294
 
Name Accession Description Interval E-value
PHA03247 PHA03247
large tegument protein UL36; Provisional
 637-741 2.78e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 2.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953412  637 ATCPGGSPGTPAPGFSSAASSALRISPPVLPLALLSPGSAI------PRPRAQLPEPDPGLPAESTGPPAPGSRRAYRLP 710
Cdd:PHA03247 2855 SVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTesfalpPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPP 2934

                          90       100       110
                  ....*....|....*....|....*....|.
gi 767953412  711 CPPRQPRLCQPGPAGLPVPGPRATAERPQAG 741
Cdd:PHA03247 2935 PPPRPQPPLAPTTDPAGAGEPSGAVPQPWLG 2965
PHA02682 PHA02682
ORF080 virion core protein; Provisional
 639-732 2.93e-03

ORF080 virion core protein; Provisional


Pssm-ID: 177464 [Multi-domain]  Cd Length: 280  Bit Score: 40.23  E-value: 2.93e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953412 639 CPGGSPGTPAPGFSSAASSALRISPPVLPLALLSPGSAIPRPRAQLPePDPGLPAESTGPPAPGSRRAYRLPcPPRQPRL 718
Cdd:PHA02682 102 APAPAVTCPAPAPACPPATAPTCPPPAVCPAPARPAPACPPSTRQCP-PAPPLPTPKPAPAAKPIFLHNQLP-PPDYPAA 179

                         90
                 ....*....|....*...
gi 767953412 719 CQP----GPAGLPVPGPR 732
Cdd:PHA02682 180 SCPtietAPAASPVLEPR 197
PHA02682 PHA02682
ORF080 virion core protein; Provisional
 629-738 3.32e-03

ORF080 virion core protein; Provisional


Pssm-ID: 177464 [Multi-domain]  Cd Length: 280  Bit Score: 40.23  E-value: 3.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953412 629 GKSKVSDHATCPGGSPGTPAPgfssaassalriSPPVLPLALLSPGSAIPRPRAQLPEPDPGLPAESTGPPAPGsrrayr 708
Cdd:PHA02682  78 GQSPLAPSPACAAPAPACPAC------------APAAPAPAVTCPAPAPACPPATAPTCPPPAVCPAPARPAPA------ 139

                         90       100       110
                 ....*....|....*....|....*....|
gi 767953412 709 lpCPPrQPRLCQPGPAgLPVPGPrATAERP 738
Cdd:PHA02682 140 --CPP-STRQCPPAPP-LPTPKP-APAAKP 164
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 637-750 4.68e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 40.47  E-value: 4.68e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953412 637 ATCPGGSP-GTPAPGFSSAASSALRISPPVLPLALLSPGSAIPRPRAQLPEPDPGLPAESTGPPAPGSRRAYRLPCPPR- 714
Cdd:PRK14951 386 AAAPAAAPvAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPAAVALAPAPPAQAAPETVAIPVr 465

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 767953412 715 -QPRLCQPGPAGLPVPGPRATAERPQAGCGRGSARVR 750
Cdd:PRK14951 466 vAPEPAVASAAPAPAAAPAAARLTPTEEGDVWHATVQ 502
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
637-752 6.59e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 39.86  E-value: 6.59e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953412 637 ATCPGGSPGTPAPGFSSAASSALRISPPVLPLALLSPGSAIPRPRAQLPEPDPGLPAESTGP----PAPGSRRAYRLPCP 712
Cdd:PRK12323 362 AFRPGQSGGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAParrsPAPEALAAARQASA 441

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 767953412 713 PRQPRLCQPGPAGLPVPGPratAERPQAGCGRGSARVRSA 752
Cdd:PRK12323 442 RGPGGAPAPAPAPAAAPAA---AARPAAAGPRPVAAAAAA 478
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 637-731 9.04e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 39.75  E-value: 9.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767953412  637 ATCPGGSPGTPAPGFSSAASSALRISPPVLPLALLSPGSAIPRPRaqLPEPDPGLpAESTGPPAPGSRRAYRLPCP---- 712
Cdd:pfam03154 197 AGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQR--LPSPHPPL-QPMTQPPPPSQVSPQPLPQPslhg 273

                          90       100
                  ....*....|....*....|.
gi 767953412  713 --PRQPRLCQPGPAGLPVPGP 731
Cdd:pfam03154 274 qmPPMPHSLQTGPSHMQHPVP 294
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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