NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|767956153|ref|XP_011516480|]
View 

A disintegrin and metalloproteinase with thrombospondin motifs 13 isoform X6 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
ADAM_CR_3 super family cl41950
ADAM cysteine-rich domain; This cysteine rich domain is found in a variety of ADAM like ...
1-110 9.70e-72

ADAM cysteine-rich domain; This cysteine rich domain is found in a variety of ADAM like peptidases. This domain is distantly related to pfam08516.


The actual alignment was detected with superfamily member pfam19236:

Pssm-ID: 437068  Cd Length: 115  Bit Score: 232.68  E-value: 9.70e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956153    1 MSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSG 80
Cdd:pfam19236   6 MSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVLG 85
                          90       100       110
                  ....*....|....*....|....*....|
gi 767956153   81 SCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 110
Cdd:pfam19236  86 SCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
ADAM_spacer1 pfam05986
ADAM-TS Spacer 1; This family represents the Spacer-1 region from the ADAM-TS family of ...
112-235 7.58e-51

ADAM-TS Spacer 1; This family represents the Spacer-1 region from the ADAM-TS family of metalloproteinases.


:

Pssm-ID: 428708  Cd Length: 115  Bit Score: 174.31  E-value: 7.58e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956153  112 PRKGSFTAGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVR-IGGRYVVAGKMSISPNTTYPSLLEDGrVEYRValted 190
Cdd:pfam05986   1 TVSGSFTEGRAKGYVTFVTIPAGATHIHIVNRKPSFTHLAVKnVQGKYILNGKGSISLNPTYPSLLGTV-LEYRR----- 74
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 767956153  191 RLPRLEEIRIWGPLQEDADIQVYRRYGEeygnLTRPDITFTYFQP 235
Cdd:pfam05986  75 SLPALEELHAPGPTQEDLEIQVLRQYGK----GTNPGITYEYFIP 115
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
631-685 1.45e-10

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 408800 [Multi-domain]  Cd Length: 55  Bit Score: 57.46  E-value: 1.45e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 767956153  631 WHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPC 685
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKLGGSLVPDSQCSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
517-567 5.09e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 408800 [Multi-domain]  Cd Length: 55  Bit Score: 50.14  E-value: 5.09e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 767956153  517 CSVSCGRGVVRRILYCARAHgeddGEEILLDTQCQGLPRPEPQEACSLEPC 567
Cdd:pfam19030   9 CSVTCGGGVQTRLVQCVQKL----GGSLVPDSQCSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
301-359 2.23e-07

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 408800 [Multi-domain]  Cd Length: 55  Bit Score: 48.22  E-value: 2.23e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767956153  301 WAVGDFGPCSASCGGGLRERPVRCVEAQGslLKTLPPARCRAGAQQPAValETCNPQPC 359
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKLG--GSLVPDSQCSAQKKPPET--QSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
571-627 1.05e-06

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 408800 [Multi-domain]  Cd Length: 55  Bit Score: 46.29  E-value: 1.05e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767956153  571 WKVMSLGPCSASCGLGTARRSVACVQLDqGQDVEVDEaACAALVRPEASVPCLIADC 627
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKL-GGSLVPDS-QCSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
457-506 1.00e-03

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 408800 [Multi-domain]  Cd Length: 55  Bit Score: 38.20  E-value: 1.00e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 767956153  457 GSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPgSRREVCQAVPC 506
Cdd:pfam19030   7 GECSVTCGGGVQTRLVQCVQKLGGSLVPDSQCSAQKKP-PETQSCNLKPC 55
 
Name Accession Description Interval E-value
ADAM_CR_3 pfam19236
ADAM cysteine-rich domain; This cysteine rich domain is found in a variety of ADAM like ...
1-110 9.70e-72

ADAM cysteine-rich domain; This cysteine rich domain is found in a variety of ADAM like peptidases. This domain is distantly related to pfam08516.


Pssm-ID: 437068  Cd Length: 115  Bit Score: 232.68  E-value: 9.70e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956153    1 MSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSG 80
Cdd:pfam19236   6 MSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVLG 85
                          90       100       110
                  ....*....|....*....|....*....|
gi 767956153   81 SCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 110
Cdd:pfam19236  86 SCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
ADAM_spacer1 pfam05986
ADAM-TS Spacer 1; This family represents the Spacer-1 region from the ADAM-TS family of ...
112-235 7.58e-51

ADAM-TS Spacer 1; This family represents the Spacer-1 region from the ADAM-TS family of metalloproteinases.


Pssm-ID: 428708  Cd Length: 115  Bit Score: 174.31  E-value: 7.58e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956153  112 PRKGSFTAGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVR-IGGRYVVAGKMSISPNTTYPSLLEDGrVEYRValted 190
Cdd:pfam05986   1 TVSGSFTEGRAKGYVTFVTIPAGATHIHIVNRKPSFTHLAVKnVQGKYILNGKGSISLNPTYPSLLGTV-LEYRR----- 74
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 767956153  191 RLPRLEEIRIWGPLQEDADIQVYRRYGEeygnLTRPDITFTYFQP 235
Cdd:pfam05986  75 SLPALEELHAPGPTQEDLEIQVLRQYGK----GTNPGITYEYFIP 115
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
631-685 1.45e-10

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 408800 [Multi-domain]  Cd Length: 55  Bit Score: 57.46  E-value: 1.45e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 767956153  631 WHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPC 685
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKLGGSLVPDSQCSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
517-567 5.09e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 408800 [Multi-domain]  Cd Length: 55  Bit Score: 50.14  E-value: 5.09e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 767956153  517 CSVSCGRGVVRRILYCARAHgeddGEEILLDTQCQGLPRPEPQEACSLEPC 567
Cdd:pfam19030   9 CSVTCGGGVQTRLVQCVQKL----GGSLVPDSQCSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
301-359 2.23e-07

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 408800 [Multi-domain]  Cd Length: 55  Bit Score: 48.22  E-value: 2.23e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767956153  301 WAVGDFGPCSASCGGGLRERPVRCVEAQGslLKTLPPARCRAGAQQPAValETCNPQPC 359
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKLG--GSLVPDSQCSAQKKPPET--QSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
571-627 1.05e-06

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 408800 [Multi-domain]  Cd Length: 55  Bit Score: 46.29  E-value: 1.05e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767956153  571 WKVMSLGPCSASCGLGTARRSVACVQLDqGQDVEVDEaACAALVRPEASVPCLIADC 627
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKL-GGSLVPDS-QCSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
457-506 1.00e-03

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 408800 [Multi-domain]  Cd Length: 55  Bit Score: 38.20  E-value: 1.00e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 767956153  457 GSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPgSRREVCQAVPC 506
Cdd:pfam19030   7 GECSVTCGGGVQTRLVQCVQKLGGSLVPDSQCSAQKKP-PETQSCNLKPC 55
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
301-360 9.71e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 35.26  E-value: 9.71e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956153   301 WAVGDFGPCSASCGGGLRERPVRCVEAQGSllktLPPARCragaQQPAVALETCNPQPCP 360
Cdd:smart00209   2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPPQ----NGGGPC----TGEDVETRACNEQPCP 53
 
Name Accession Description Interval E-value
ADAM_CR_3 pfam19236
ADAM cysteine-rich domain; This cysteine rich domain is found in a variety of ADAM like ...
1-110 9.70e-72

ADAM cysteine-rich domain; This cysteine rich domain is found in a variety of ADAM like peptidases. This domain is distantly related to pfam08516.


Pssm-ID: 437068  Cd Length: 115  Bit Score: 232.68  E-value: 9.70e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956153    1 MSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSG 80
Cdd:pfam19236   6 MSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVLG 85
                          90       100       110
                  ....*....|....*....|....*....|
gi 767956153   81 SCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 110
Cdd:pfam19236  86 SCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
ADAM_spacer1 pfam05986
ADAM-TS Spacer 1; This family represents the Spacer-1 region from the ADAM-TS family of ...
112-235 7.58e-51

ADAM-TS Spacer 1; This family represents the Spacer-1 region from the ADAM-TS family of metalloproteinases.


Pssm-ID: 428708  Cd Length: 115  Bit Score: 174.31  E-value: 7.58e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956153  112 PRKGSFTAGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVR-IGGRYVVAGKMSISPNTTYPSLLEDGrVEYRValted 190
Cdd:pfam05986   1 TVSGSFTEGRAKGYVTFVTIPAGATHIHIVNRKPSFTHLAVKnVQGKYILNGKGSISLNPTYPSLLGTV-LEYRR----- 74
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 767956153  191 RLPRLEEIRIWGPLQEDADIQVYRRYGEeygnLTRPDITFTYFQP 235
Cdd:pfam05986  75 SLPALEELHAPGPTQEDLEIQVLRQYGK----GTNPGITYEYFIP 115
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
631-685 1.45e-10

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 408800 [Multi-domain]  Cd Length: 55  Bit Score: 57.46  E-value: 1.45e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 767956153  631 WHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPC 685
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKLGGSLVPDSQCSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
517-567 5.09e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 408800 [Multi-domain]  Cd Length: 55  Bit Score: 50.14  E-value: 5.09e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 767956153  517 CSVSCGRGVVRRILYCARAHgeddGEEILLDTQCQGLPRPEPQEACSLEPC 567
Cdd:pfam19030   9 CSVTCGGGVQTRLVQCVQKL----GGSLVPDSQCSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
301-359 2.23e-07

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 408800 [Multi-domain]  Cd Length: 55  Bit Score: 48.22  E-value: 2.23e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767956153  301 WAVGDFGPCSASCGGGLRERPVRCVEAQGslLKTLPPARCRAGAQQPAValETCNPQPC 359
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKLG--GSLVPDSQCSAQKKPPET--QSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
571-627 1.05e-06

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 408800 [Multi-domain]  Cd Length: 55  Bit Score: 46.29  E-value: 1.05e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767956153  571 WKVMSLGPCSASCGLGTARRSVACVQLDqGQDVEVDEaACAALVRPEASVPCLIADC 627
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKL-GGSLVPDS-QCSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
457-506 1.00e-03

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 408800 [Multi-domain]  Cd Length: 55  Bit Score: 38.20  E-value: 1.00e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 767956153  457 GSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPgSRREVCQAVPC 506
Cdd:pfam19030   7 GECSVTCGGGVQTRLVQCVQKLGGSLVPDSQCSAQKKP-PETQSCNLKPC 55
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
301-360 9.71e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 35.26  E-value: 9.71e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956153   301 WAVGDFGPCSASCGGGLRERPVRCVEAQGSllktLPPARCragaQQPAVALETCNPQPCP 360
Cdd:smart00209   2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPPQ----NGGGPC----TGEDVETRACNEQPCP 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH