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Conserved domains on  [gi|767956194|ref|XP_011516496|]
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WD repeat-containing protein 31 isoform X3 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
61-325 3.42e-32

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 453027 [Multi-domain]  Cd Length: 289  Bit Score: 121.67  E-value: 3.42e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956194  61 HMDTVSVVAAL-NSDLCVSGGKDK-------------------------VACIPKSSQFFSASRDRMVMMWDLHgSSQPR 114
Cdd:cd00200    8 HTGGVTCVAFSpDGKLLATGSGDGtikvwdletgellrtlkghtgpvrdVAASADGTYLASGSSDKTIRLWDLE-TGECV 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956194 115 QQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHLCWVPREPYILQTSEDKTLRLWDSRG 194
Cdd:cd00200   87 RTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRT 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956194 195 LQVAHMFPAkqHIQTYCEVSV--DGHKCISCSNGfggegCEATLWDLRQTRNrICEYKGHFQTVASCVFLPRALalmpLI 272
Cdd:cd00200  167 GKCVATLTG--HTGEVNSVAFspDGEKLLSSSSD-----GTIKLWDLSTGKC-LGTLRGHENGVNSVAFSPDGY----LL 234
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767956194 273 ATSSHDCKVKIWNQDTGACLFTLSLdGSGPLTSLAV-GDAISLLCASFNRGIHL 325
Cdd:cd00200  235 ASGSEDGTIRVWDLRTGECVQTLSG-HTNSVTSLAWsPDGKRLASGSADGTIRI 287
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
61-325 3.42e-32

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 121.67  E-value: 3.42e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956194  61 HMDTVSVVAAL-NSDLCVSGGKDK-------------------------VACIPKSSQFFSASRDRMVMMWDLHgSSQPR 114
Cdd:cd00200    8 HTGGVTCVAFSpDGKLLATGSGDGtikvwdletgellrtlkghtgpvrdVAASADGTYLASGSSDKTIRLWDLE-TGECV 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956194 115 QQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHLCWVPREPYILQTSEDKTLRLWDSRG 194
Cdd:cd00200   87 RTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRT 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956194 195 LQVAHMFPAkqHIQTYCEVSV--DGHKCISCSNGfggegCEATLWDLRQTRNrICEYKGHFQTVASCVFLPRALalmpLI 272
Cdd:cd00200  167 GKCVATLTG--HTGEVNSVAFspDGEKLLSSSSD-----GTIKLWDLSTGKC-LGTLRGHENGVNSVAFSPDGY----LL 234
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767956194 273 ATSSHDCKVKIWNQDTGACLFTLSLdGSGPLTSLAV-GDAISLLCASFNRGIHL 325
Cdd:cd00200  235 ASGSEDGTIRVWDLRTGECVQTLSG-HTNSVTSLAWsPDGKRLASGSADGTIRI 287
WD40 COG2319
WD40 repeat [General function prediction only];
88-318 1.20e-25

WD40 repeat [General function prediction only];


Pssm-ID: 225201 [Multi-domain]  Cd Length: 466  Bit Score: 106.71  E-value: 1.20e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956194  88 PKSSQFFSA--SRDRMVMMWDLHGSSQPRQQLCGHAMVVTGLAVSPDSSQLCTGSR-DNTLLLWDVVTGQSVERASVSRN 164
Cdd:COG2319  120 PDGNSILLAssSLDGTVKLWDLSTPGKLIRTLEGHSESVTSLAFSPDGKLLASGSSlDGTIKLWDLRTGKPLSTLAGHTD 199
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956194 165 VVTHLCWVPREPYILQT-SEDKTLRLWDSRGLQVAHMFPAKQHIQTYCEVSVDGHKCISCSngfggEGCEATLWDLRQTR 243
Cdd:COG2319  200 PVSSLAFSPDGGLLIASgSSDGTIRLWDLSTGKLLRSTLSGHSDSVVSSFSPDGSLLASGS-----SDGTIRLWDLRSSS 274
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767956194 244 NRICEYKGHFQTVASCVFLPRAlalmPLIATSSHDCKVKIWNQDTGACLFTLSLDG-SGPLTSLAVGDAISLLCAS 318
Cdd:COG2319  275 SLLRTLSGHSSSVLSVAFSPDG----KLLASGSSDGTVRLWDLETGKLLSSLTLKGhEGPVSSLSFSPDGSLLVSG 346
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
110-149 6.96e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 6.96e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 767956194   110 SSQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWD 149
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
111-149 4.18e-06

WD domain, G-beta repeat;


Pssm-ID: 425662 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 4.18e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 767956194  111 SQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWD 149
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
90-241 6.64e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 47.58  E-value: 6.64e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956194  90 SSQFFSASRDRMVMMWDL------HGSSQPRQQLCGHAMVVTGLAVSPDSSQ-LCTGSRDNTLLLWDVVTGQSVERASVS 162
Cdd:PTZ00421  88 PQKLFTASEDGTIMGWGIpeegltQNISDPIVHLQGHTKKVGIVSFHPSAMNvLASAGADMVVNVWDVERGKAVEVIKCH 167
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956194 163 RNVVTHLCWVPREPYILQTSEDKTLRLWDSRGLQVAHMFPAKQhiqtycevSVDGHKCISC--SNGFGGEGC------EA 234
Cdd:PTZ00421 168 SDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHA--------SAKSQRCLWAkrKDLIITLGCsksqqrQI 239

                 ....*..
gi 767956194 235 TLWDLRQ 241
Cdd:PTZ00421 240 MLWDTRK 246
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
61-325 3.42e-32

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 121.67  E-value: 3.42e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956194  61 HMDTVSVVAAL-NSDLCVSGGKDK-------------------------VACIPKSSQFFSASRDRMVMMWDLHgSSQPR 114
Cdd:cd00200    8 HTGGVTCVAFSpDGKLLATGSGDGtikvwdletgellrtlkghtgpvrdVAASADGTYLASGSSDKTIRLWDLE-TGECV 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956194 115 QQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHLCWVPREPYILQTSEDKTLRLWDSRG 194
Cdd:cd00200   87 RTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRT 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956194 195 LQVAHMFPAkqHIQTYCEVSV--DGHKCISCSNGfggegCEATLWDLRQTRNrICEYKGHFQTVASCVFLPRALalmpLI 272
Cdd:cd00200  167 GKCVATLTG--HTGEVNSVAFspDGEKLLSSSSD-----GTIKLWDLSTGKC-LGTLRGHENGVNSVAFSPDGY----LL 234
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767956194 273 ATSSHDCKVKIWNQDTGACLFTLSLdGSGPLTSLAV-GDAISLLCASFNRGIHL 325
Cdd:cd00200  235 ASGSEDGTIRVWDLRTGECVQTLSG-HTNSVTSLAWsPDGKRLASGSADGTIRI 287
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
61-285 3.47e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 105.49  E-value: 3.47e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956194  61 HMDTVSVVAAL-NSDLCVSGGKDK-------------------------VACIPKSSQFFSASRDRMVMMWDLHgSSQPR 114
Cdd:cd00200   50 HTGPVRDVAASaDGTYLASGSSDKtirlwdletgecvrtltghtsyvssVAFSPDGRILSSSSRDKTIKVWDVE-TGKCL 128
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956194 115 QQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHLCWVPREPYILQTSEDKTLRLWDSRG 194
Cdd:cd00200  129 TTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLST 208
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956194 195 LQVAHMFPAKQHIQTYCEVSVDGHKCISCSngfggEGCEATLWDLRqTRNRICEYKGHFQTVASCVFLPRALALmpliAT 274
Cdd:cd00200  209 GKCLGTLRGHENGVNSVAFSPDGYLLASGS-----EDGTIRVWDLR-TGECVQTLSGHTNSVTSLAWSPDGKRL----AS 278
                        250
                 ....*....|.
gi 767956194 275 SSHDCKVKIWN 285
Cdd:cd00200  279 GSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
88-318 1.20e-25

WD40 repeat [General function prediction only];


Pssm-ID: 225201 [Multi-domain]  Cd Length: 466  Bit Score: 106.71  E-value: 1.20e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956194  88 PKSSQFFSA--SRDRMVMMWDLHGSSQPRQQLCGHAMVVTGLAVSPDSSQLCTGSR-DNTLLLWDVVTGQSVERASVSRN 164
Cdd:COG2319  120 PDGNSILLAssSLDGTVKLWDLSTPGKLIRTLEGHSESVTSLAFSPDGKLLASGSSlDGTIKLWDLRTGKPLSTLAGHTD 199
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956194 165 VVTHLCWVPREPYILQT-SEDKTLRLWDSRGLQVAHMFPAKQHIQTYCEVSVDGHKCISCSngfggEGCEATLWDLRQTR 243
Cdd:COG2319  200 PVSSLAFSPDGGLLIASgSSDGTIRLWDLSTGKLLRSTLSGHSDSVVSSFSPDGSLLASGS-----SDGTIRLWDLRSSS 274
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767956194 244 NRICEYKGHFQTVASCVFLPRAlalmPLIATSSHDCKVKIWNQDTGACLFTLSLDG-SGPLTSLAVGDAISLLCAS 318
Cdd:COG2319  275 SLLRTLSGHSSSVLSVAFSPDG----KLLASGSSDGTVRLWDLETGKLLSSLTLKGhEGPVSSLSFSPDGSLLVSG 346
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
113-325 4.06e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 97.02  E-value: 4.06e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956194 113 PRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHLCWVPREPYILQTSEDKTLRLWDS 192
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956194 193 RGLQVAHMFpaKQHIQ--TYCEVSVDGHkCISCSngfgGEGCEATLWDLRQTRNRICeYKGHFQTVASCVFLPRALalmp 270
Cdd:cd00200   81 ETGECVRTL--TGHTSyvSSVAFSPDGR-ILSSS----SRDKTIKVWDVETGKCLTT-LRGHTDWVNSVAFSPDGT---- 148
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767956194 271 LIATSSHDCKVKIWNQDTGACLFTLSlDGSGPLTSLAV-GDAISLLCASFNRGIHL 325
Cdd:cd00200  149 FVASSSQDGTIKLWDLRTGKCVATLT-GHTGEVNSVAFsPDGEKLLSSSSDGTIKL 203
WD40 COG2319
WD40 repeat [General function prediction only];
84-308 4.61e-19

WD40 repeat [General function prediction only];


Pssm-ID: 225201 [Multi-domain]  Cd Length: 466  Bit Score: 87.84  E-value: 4.61e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956194  84 VACIPKSSQFFSASR-DRMVMMWDLHgSSQPRQQLCGHAMVVTGLAVSPDSS-QLCTGSRDNTLLLWDVVTGQSVERASV 161
Cdd:COG2319  161 LAFSPDGKLLASGSSlDGTIKLWDLR-TGKPLSTLAGHTDPVSSLAFSPDGGlLIASGSSDGTIRLWDLSTGKLLRSTLS 239
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956194 162 SRNVVTHLCWVPREPYILQTSEDKTLRLWDSRGLQVAHMFPAKqHIQTYCEVSVDGHKCISCSngfGGEGCEATLWDLRQ 241
Cdd:COG2319  240 GHSDSVVSSFSPDGSLLASGSSDGTIRLWDLRSSSSLLRTLSG-HSSSVLSVAFSPDGKLLAS---GSSDGTVRLWDLET 315
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767956194 242 TRNR-ICEYKGHFQTVASCVFLPRalaLMPLIATSSHDCKVKIWNQDTGACLFTlsLDGSGPLTSLAV 308
Cdd:COG2319  316 GKLLsSLTLKGHEGPVSSLSFSPD---GSLLVSGGSDDGTIRLWDLRTGKPLKT--LEGHSNVLSVSF 378
WD40 COG2319
WD40 repeat [General function prediction only];
88-300 1.68e-18

WD40 repeat [General function prediction only];


Pssm-ID: 225201 [Multi-domain]  Cd Length: 466  Bit Score: 85.91  E-value: 1.68e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956194  88 PKSSQFFSASRDRMVMMWDLHGSSQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWDVVTGQSVERASV--SRNV 165
Cdd:COG2319  251 PDGSLLASGSSDGTIRLWDLRSSSSLLRTLSGHSSSVLSVAFSPDGKLLASGSSDGTVRLWDLETGKLLSSLTLkgHEGP 330
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956194 166 VTHLCWVPREPYIL-QTSEDKTLRLWDSRGLQVAHMFpaKQHIQTYCEVSVDGHKCIScsngFGGEGCEATLWDLrQTRN 244
Cdd:COG2319  331 VSSLSFSPDGSLLVsGGSDDGTIRLWDLRTGKPLKTL--EGHSNVLSVSFSPDGRVVS----SGSTDGTVRLWDL-STGS 403
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767956194 245 RICEYKGHFQTVASCVFLPRAlalmPLIATSSHDCKVKIWNQDTGACLFTLSLDGS 300
Cdd:COG2319  404 LLRNLDGHTSRVTSLDFSPDG----KSLASGSSDNTIRLWDLKTSLKSVSFSPDGK 455
WD40 COG2319
WD40 repeat [General function prediction only];
29-332 1.17e-17

WD40 repeat [General function prediction only];


Pssm-ID: 225201 [Multi-domain]  Cd Length: 466  Bit Score: 83.60  E-value: 1.17e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956194  29 SKLKHSTYKYGRPDEIIEERIQTKAFQEYSPAHMDTVSVVAALNSDLcVSGGKDKVACI---PKSSQFFSASRDRMVMMW 105
Cdd:COG2319   14 KLLKKSELGPSLNSLSLLSLGSSESGILLLALLSDSLVSLPDLSSLL-LRGHEDSITSIafsPDGELLLSGSSDGTIKLW 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956194 106 DLHGSSQPRQQLCG-HAMVVTGLAV-SPDSSQL--CTGSRDNTLLLWDVVT-GQSVERASVSRNVVTHLCWVPREPYILQ 180
Cdd:COG2319   93 DLDNGEKLIKSLEGlHDSSVSKLALsSPDGNSIllASSSLDGTVKLWDLSTpGKLIRTLEGHSESVTSLAFSPDGKLLAS 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956194 181 TSE-DKTLRLWDSRGLQVAHMFPAKQHIQTYCEVSVDGHKCISCsngfGGEGCEATLWDLRQTRNRICEYKGHFQTVASC 259
Cdd:COG2319  173 GSSlDGTIKLWDLRTGKPLSTLAGHTDPVSSLAFSPDGGLLIAS----GSSDGTIRLWDLSTGKLLRSTLSGHSDSVVSS 248
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767956194 260 vFLPRalalMPLIATSSHDCKVKIWNQDTGACLFTLSLDGSGPLTSLAV-GDAISLLCASFNRGIHLLRMDHSQ 332
Cdd:COG2319  249 -FSPD----GSLLASGSSDGTIRLWDLRSSSSLLRTLSGHSSSVLSVAFsPDGKLLASGSSDGTVRLWDLETGK 317
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
110-149 6.96e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 6.96e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 767956194   110 SSQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWD 149
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
111-149 4.18e-06

WD domain, G-beta repeat;


Pssm-ID: 425662 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 4.18e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 767956194  111 SQPRQQLCGHAMVVTGLAVSPDSSQLCTGSRDNTLLLWD 149
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
90-241 6.64e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 47.58  E-value: 6.64e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956194  90 SSQFFSASRDRMVMMWDL------HGSSQPRQQLCGHAMVVTGLAVSPDSSQ-LCTGSRDNTLLLWDVVTGQSVERASVS 162
Cdd:PTZ00421  88 PQKLFTASEDGTIMGWGIpeegltQNISDPIVHLQGHTKKVGIVSFHPSAMNvLASAGADMVVNVWDVERGKAVEVIKCH 167
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956194 163 RNVVTHLCWVPREPYILQTSEDKTLRLWDSRGLQVAHMFPAKQhiqtycevSVDGHKCISC--SNGFGGEGC------EA 234
Cdd:PTZ00421 168 SDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHA--------SAKSQRCLWAkrKDLIITLGCsksqqrQI 239

                 ....*..
gi 767956194 235 TLWDLRQ 241
Cdd:PTZ00421 240 MLWDTRK 246
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
134-306 3.62e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 42.38  E-value: 3.62e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956194 134 SQLCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHLCWVPREPYILQT-SEDKTLRLWD-SRGLQVAHMfPAKQHIqtyC 211
Cdd:PLN00181 546 SQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASgSDDGSVKLWSiNQGVSIGTI-KTKANI---C 621
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956194 212 EVSVDGHKCISCSngFGGEGCEATLWDLRQTRNRICEYKGHFQTVASCVFLPRAlalmpLIATSSHDCKVKIWNqdtgac 291
Cdd:PLN00181 622 CVQFPSESGRSLA--FGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFVDSS-----TLVSSSTDNTLKLWD------ 688
                        170
                 ....*....|....*....
gi 767956194 292 lftLSLDGSG----PLTSL 306
Cdd:PLN00181 689 ---LSMSISGinetPLHSF 704
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
242-285 2.84e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.98  E-value: 2.84e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 767956194   242 TRNRICEYKGHFQTVASCVFLPRAlalmPLIATSSHDCKVKIWN 285
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDG----KYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
152-191 6.90e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 33.83  E-value: 6.90e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 767956194   152 TGQSVERASVSRNVVTHLCWVPREPYILQTSEDKTLRLWD 191
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
243-285 7.14e-03

WD domain, G-beta repeat;


Pssm-ID: 425662 [Multi-domain]  Cd Length: 39  Bit Score: 33.86  E-value: 7.14e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 767956194  243 RNRICEYKGHFQTVASCVFLPRAlalmPLIATSSHDCKVKIWN 285
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDG----KLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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