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Conserved domains on  [gi|767958514|ref|XP_011517416|]
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hippocampus abundant transcript-like protein 1 isoform X1 [Homo sapiens]

Protein Classification

MFSD14 family MFS transporter( domain architecture ID 13024393)

MFSD14 family major facilitator superfamily (MFS) transporter such as MFS domain-containing 14A and 14B, also called hippocampus abundant transcript 1 protein (HIAT1) and hippocampus abundant transcript-like protein 1 (HIATL1), respectively; MFSD14A may transport a solute from the bloodstream that is required for spermiogenesis

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26098515|26758938
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_MFSD14 cd17387
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of ...
 1-385 0e+00

Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of major facilitator superfamily domain-containing 14A (MFSD14A) and MFSD14B, and similar proteins. MFSD14A and MFSD14B are also called hippocampus abundant transcript 1 protein (HIAT1) and hippocampus abundant transcript-like protein 1 (HIATL1), respectively. They are both ubiquitously expressed with HIAT1 highly expressed intestis and HIATL1 most abundantly expressed in skeletal muscle. Gene disruption of MFSD14A causes globozoospermia and infertility in male mice. It has bee suggested that MFSD14A may transport a solute from the bloodstream that is required for spermiogenesis. The function of MFSD14B is unknown. The MFSD14 subfamily belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340945 [Multi-domain]  Cd Length: 410  Bit Score: 664.50  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514   1 MLTVLHETFSQHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKPFLLGTVFFTCFPIPLMRISPWWYFAMISVSGVFS 80
Cdd:cd17387   22 MITVLHETFPQHTFLMNGLVQGVKGILSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMRISPWWYFAMISVSGIFS 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  81 VTFSVIFAYVADVTQEHERSTAYGWVSATFAASLVSSPAIGAYLSASYGDSLVVLVATVVALLDICFILVAVPESLPEKM 160
Cdd:cd17387  102 VTFSVIFAYVADITTEEERSTAYGLVSATFAASLVTSPALGAYLSESYGDNLVVLVATIVALLDICFILLAVPESLPEKM 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 161 RPVSWGAQISWKQADPFASLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQVIGFGSVKIAAFIAMVGILSIVAQ 240
Cdd:cd17387  182 RPASWGAPISWEQADPFASLRKVGKDKTVLLICITVFLSYLPEAGQYSSFFVYLKQVMGFEYEEVAAFIAVVGILSITAQ 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 241 TAFLSILMRSLGNKNTVLLGLGFQMLQLAWYGFGSQAWMMWAAGTVAAMSSITFPAISALVSRNAESDQQGVAQGIITGI 320
Cdd:cd17387  262 TLLLSILMRSIGAKNTILLGLGFQMLQLAWYGFGSQHWMMWAAGAVAAMSSITFPAISALVSRYADPDQQGAVQGMITGI 341

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767958514 321 RGLCNGLGPALYGFIFYMFHVELTELGP----KLNSNNVPLQGAVIPGPPFLFGACIVLMSFLVALFIP 385
Cdd:cd17387  342 RGLCNGLGPALFGFVFYLFHVDLNEIKPvqssKQRMQNPSLEGAIIPGPPFLFGAISVLLAILVASFIP 410
 
Name Accession Description Interval E-value
MFS_MFSD14 cd17387
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of ...
 1-385 0e+00

Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of major facilitator superfamily domain-containing 14A (MFSD14A) and MFSD14B, and similar proteins. MFSD14A and MFSD14B are also called hippocampus abundant transcript 1 protein (HIAT1) and hippocampus abundant transcript-like protein 1 (HIATL1), respectively. They are both ubiquitously expressed with HIAT1 highly expressed intestis and HIATL1 most abundantly expressed in skeletal muscle. Gene disruption of MFSD14A causes globozoospermia and infertility in male mice. It has bee suggested that MFSD14A may transport a solute from the bloodstream that is required for spermiogenesis. The function of MFSD14B is unknown. The MFSD14 subfamily belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340945 [Multi-domain]  Cd Length: 410  Bit Score: 664.50  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514   1 MLTVLHETFSQHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKPFLLGTVFFTCFPIPLMRISPWWYFAMISVSGVFS 80
Cdd:cd17387   22 MITVLHETFPQHTFLMNGLVQGVKGILSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMRISPWWYFAMISVSGIFS 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  81 VTFSVIFAYVADVTQEHERSTAYGWVSATFAASLVSSPAIGAYLSASYGDSLVVLVATVVALLDICFILVAVPESLPEKM 160
Cdd:cd17387  102 VTFSVIFAYVADITTEEERSTAYGLVSATFAASLVTSPALGAYLSESYGDNLVVLVATIVALLDICFILLAVPESLPEKM 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 161 RPVSWGAQISWKQADPFASLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQVIGFGSVKIAAFIAMVGILSIVAQ 240
Cdd:cd17387  182 RPASWGAPISWEQADPFASLRKVGKDKTVLLICITVFLSYLPEAGQYSSFFVYLKQVMGFEYEEVAAFIAVVGILSITAQ 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 241 TAFLSILMRSLGNKNTVLLGLGFQMLQLAWYGFGSQAWMMWAAGTVAAMSSITFPAISALVSRNAESDQQGVAQGIITGI 320
Cdd:cd17387  262 TLLLSILMRSIGAKNTILLGLGFQMLQLAWYGFGSQHWMMWAAGAVAAMSSITFPAISALVSRYADPDQQGAVQGMITGI 341

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767958514 321 RGLCNGLGPALYGFIFYMFHVELTELGP----KLNSNNVPLQGAVIPGPPFLFGACIVLMSFLVALFIP 385
Cdd:cd17387  342 RGLCNGLGPALFGFVFYLFHVDLNEIKPvqssKQRMQNPSLEGAIIPGPPFLFGAISVLLAILVASFIP 410
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
18-327 1.65e-23

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 100.82  E-value: 1.65e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  18 GLIQGVKGLLSFLSAPLIGALSDVWGRKPFLLGTVFFTCFPIPLMRISP--WWYFAMISVSGVFS-VTFSVIFAYVADVT 94
Cdd:COG2814   48 GLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPslWLLLAARFLQGLGAgALFPAALALIADLV 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  95 QEHERSTAYGWVSATFAASLVSSPAIGAYLSASYGDSLVVLVATVVALLDICFILVAVPESLPEKMRPVSwgaqiswkqa 174
Cdd:COG2814  128 PPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLR---------- 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 175 dpfASLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQVIGFGSVKIAAFIAMVGILSIVAQtAFLSILMRSLGNK 254
Cdd:COG2814  198 ---GSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGA-LLAGRLADRFGRR 273

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767958514 255 NTVLLGLGFQMLQLAWYGFGSQAWMMWAAGTVAAMS-SITFPAISALVSRNAESDQQGVAQGIITGIRGLCNGL 327
Cdd:COG2814  274 RLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGfGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
MFS_1 pfam07690
Major Facilitator Superfamily;
18-329 5.86e-18

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 84.78  E-value: 5.86e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514   18 GLIQGVKGLLSFLSAPLIGALSDVWGRKPFLLGTVFFTCFP--IPLMRISPWWYFAMISVSGVF-SVTFSVIFAYVADVT 94
Cdd:pfam07690  35 GLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGllLLLFASSLWLLLVLRVLQGLGaGALFPAALALIADWF 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514   95 QEHERSTAYGWVSATFAASLVSSPAIGAYLSASYGDSLVVLVATVVALldICFILVAVPESLPEKMRPVSWGAqiswKQA 174
Cdd:pfam07690 115 PPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSL--LAAVLLLLPRPPPESKRPKPAEE----ARL 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  175 DPFASLKKVGKDstVLLICITVFLSYLPEAGQYSSFFLYLRQVIGFGSVKIAAFIAMVGILSIVAQtAFLSILMRSLGNK 254
Cdd:pfam07690 189 SLIVAWKALLRD--PVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGR-LLLGRLSDRLGRR 265

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767958514  255 NTVLLGLGFQMLQLAWYGF----GSQAWMMWAAGTVAAMSSITFPAISALVSRNAESDQQGVAQGIITGIRGLCNGLGP 329
Cdd:pfam07690 266 RRLLLALLLLILAALGLLLlsltLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
 
Name Accession Description Interval E-value
MFS_MFSD14 cd17387
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of ...
 1-385 0e+00

Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of major facilitator superfamily domain-containing 14A (MFSD14A) and MFSD14B, and similar proteins. MFSD14A and MFSD14B are also called hippocampus abundant transcript 1 protein (HIAT1) and hippocampus abundant transcript-like protein 1 (HIATL1), respectively. They are both ubiquitously expressed with HIAT1 highly expressed intestis and HIATL1 most abundantly expressed in skeletal muscle. Gene disruption of MFSD14A causes globozoospermia and infertility in male mice. It has bee suggested that MFSD14A may transport a solute from the bloodstream that is required for spermiogenesis. The function of MFSD14B is unknown. The MFSD14 subfamily belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340945 [Multi-domain]  Cd Length: 410  Bit Score: 664.50  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514   1 MLTVLHETFSQHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKPFLLGTVFFTCFPIPLMRISPWWYFAMISVSGVFS 80
Cdd:cd17387   22 MITVLHETFPQHTFLMNGLVQGVKGILSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMRISPWWYFAMISVSGIFS 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  81 VTFSVIFAYVADVTQEHERSTAYGWVSATFAASLVSSPAIGAYLSASYGDSLVVLVATVVALLDICFILVAVPESLPEKM 160
Cdd:cd17387  102 VTFSVIFAYVADITTEEERSTAYGLVSATFAASLVTSPALGAYLSESYGDNLVVLVATIVALLDICFILLAVPESLPEKM 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 161 RPVSWGAQISWKQADPFASLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQVIGFGSVKIAAFIAMVGILSIVAQ 240
Cdd:cd17387  182 RPASWGAPISWEQADPFASLRKVGKDKTVLLICITVFLSYLPEAGQYSSFFVYLKQVMGFEYEEVAAFIAVVGILSITAQ 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 241 TAFLSILMRSLGNKNTVLLGLGFQMLQLAWYGFGSQAWMMWAAGTVAAMSSITFPAISALVSRNAESDQQGVAQGIITGI 320
Cdd:cd17387  262 TLLLSILMRSIGAKNTILLGLGFQMLQLAWYGFGSQHWMMWAAGAVAAMSSITFPAISALVSRYADPDQQGAVQGMITGI 341

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767958514 321 RGLCNGLGPALYGFIFYMFHVELTELGP----KLNSNNVPLQGAVIPGPPFLFGACIVLMSFLVALFIP 385
Cdd:cd17387  342 RGLCNGLGPALFGFVFYLFHVDLNEIKPvqssKQRMQNPSLEGAIIPGPPFLFGAISVLLAILVASFIP 410
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 9-383 1.62e-63

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 208.59  E-value: 1.62e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514   9 FSQHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKPFLLGTVFFTCFPIPLMRISP--WWYFAMISVSGVFSVTFSVI 86
Cdd:cd17330   28 KLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRnlWLLFLARFLDGLTGGNVSVA 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  87 FAYVADVTQEHERSTAYGWVSATFAASLVSSPAIGAYLSASYGDSLVVLVATVVALLDICFILVAVPeslpekmrpvswg 166
Cdd:cd17330  108 QAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLFFLP------------- 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 167 aqiswkqadpfaslkkvgkdsTVLLICITVFLSYLPEAGQYSSFFLYLRQVIGFGSVKIAAFIAMVGILSIVAQTAFLSI 246
Cdd:cd17330  175 ---------------------PLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLLIPR 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 247 LMRSLGNKNTVLLGLGFQMLQLAWYGFGS-QAWMMWAAGTVAAMSSITFPAISALVSRNAESDQQGVAQGIITGIRGLCN 325
Cdd:cd17330  234 LAKRLGERKLLRLGLLLAIIGLLLLPFASsVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLAR 313

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 767958514 326 GLGPALYGFIFymfhveltelgpklnsnnvplqGAVIPGPPFLFGACIVLMSFLVALF 383
Cdd:cd17330  314 IIGPLLAGPLY----------------------SFLGPGVPFLLAAGLLLIALFLLSL 349
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 17-383 1.40e-40

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 148.94  E-value: 1.40e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  17 NGLIQGVKGLLSFLSAPLIGALSDVWGRKPFLLGTVFFTCFPIPLMRISP--WWYFAMISVSGVFSVTFSVIFAYVADVT 94
Cdd:cd17388   40 YGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDYLLMAFAPtlWWLYLGRIIAGITGATGAVAAAYIADVT 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  95 QEHERSTAYGWVSATFAASLVSSPAIGAYLsASYGDSLVVLVATVVALLDICFILVAVPESLPEKMRPvswgaQISWKQA 174
Cdd:cd17388  120 PPEQRARNFGLLGAAFGLGFIAGPALGGLL-GEISPRAPFLVAAGLNGLNFLLGLFVLPESLPPERRR-----AFRWRRA 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 175 DPFASLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQVIGFGSVKIAAFIAMVGILSIVAQTAFLSILMRSLGNK 254
Cdd:cd17388  194 NPFGSLRWLTGFPGLLGLLAVFFLIQLIGQVPATTWVLFTEDRFDWSPTMVGLSLAVFGLLHALFQAFVTGPIAKRLGEK 273

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 255 NTVLLGLGFQMLQLAWYGFGSQAWMMWAAGTVAAMSSITFPAISALVSRNAESDQQGVAQGIITGIRGLCNGLGPALYGF 334
Cdd:cd17388  274 RAILLGLAADALGFLLLAFATQGWMVFPILILLALGGIAGPALQGLLSRQVPENEQGELQGVLTSLTSLTSIIGPLLFTG 353

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*....
gi 767958514 335 IFYMFhveltelgpklnsnnvplqGAVIPGPPFLFGACIVLMSFLVALF 383
Cdd:cd17388  354 IFAAS-------------------PATWPGLAWIIGAALYLICLVLAYR 383
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 15-384 1.96e-27

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 112.28  E-value: 1.96e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  15 LMNGLIQGVKGLLSFLSAPLIGALSDVWGRKPFLL-GTVFFTCFPIPLMRISPWWYFAMISV-SGVFS-VTFSVIFAYVA 91
Cdd:cd17325   31 AQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLlGLLLLAVSTLLFAFATSYWQLLLARFlQGLASaAVWPAAMALIA 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  92 DVTQEHERSTAYGWVSATFAASLVSSPAIGAYLSASYGDSLVVLVATVVALLDICFILVAVPESLPEKmrpvswgAQISW 171
Cdd:cd17325  111 DIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPP-------NKRAV 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 172 KQADPFASLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQVIGFGSVKIAAFIAMVGILSIVAQtAFLSILMRSL 251
Cdd:cd17325  184 SAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQ-PPAGKLSDRI 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 252 GNKNTVLLGLGFQMLQLAWYGFGSQAWMMWAAGTVA-AMSSITFPAISALVSRNAESDQQGVAQGIITGIRGLCNGLGPA 330
Cdd:cd17325  263 GRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLgLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPL 342

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767958514 331 LYGFIFYMFHveltelgpklnsnnvplqgaviPGPPFLFGACIVLMSFLVALFI 384
Cdd:cd17325  343 LGGFLYDAFG----------------------FATPFLAAAALLLLAAVLFLLL 374
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
18-327 1.65e-23

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 100.82  E-value: 1.65e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  18 GLIQGVKGLLSFLSAPLIGALSDVWGRKPFLLGTVFFTCFPIPLMRISP--WWYFAMISVSGVFS-VTFSVIFAYVADVT 94
Cdd:COG2814   48 GLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPslWLLLAARFLQGLGAgALFPAALALIADLV 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  95 QEHERSTAYGWVSATFAASLVSSPAIGAYLSASYGDSLVVLVATVVALLDICFILVAVPESLPEKMRPVSwgaqiswkqa 174
Cdd:COG2814  128 PPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLR---------- 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 175 dpfASLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQVIGFGSVKIAAFIAMVGILSIVAQtAFLSILMRSLGNK 254
Cdd:COG2814  198 ---GSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGA-LLAGRLADRFGRR 273

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767958514 255 NTVLLGLGFQMLQLAWYGFGSQAWMMWAAGTVAAMS-SITFPAISALVSRNAESDQQGVAQGIITGIRGLCNGL 327
Cdd:COG2814  274 RLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGfGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 18-340 2.46e-20

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 92.10  E-value: 2.46e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  18 GLIQGVKGLLSFLSAPLIGALSDVWGRKPFLLGTVFFTCFPIPLMRISPWWYFAMIS---VSGVFSVTFSVIFAYVADVT 94
Cdd:cd06174   34 GLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGrflLGLGSGLIDPAVLALIADLF 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  95 QEHERSTAYGWVSATFAASLVSSPAIGAYLSASYGDSLVVLVATVVALLDICFIL-VAVPESLPEKMRPVSwgaqISWKQ 173
Cdd:cd06174  114 PERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAALALLAAILlLLVVPDPPESARAKN----EEASS 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 174 ADPFASLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQVIGFGSVKIAAFIAMVGILSIVAQTAFLSILMRSLGN 253
Cdd:cd06174  190 KSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGR 269

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 254 KNTVLLGLGFQMLQLAWYGFGSQAWMMWAAGT-VAAMSSITFPAISALVSRNAESDQQGVAQGIITGIRGLCNGLGPALY 332
Cdd:cd06174  270 KPLLLIGLLLMALGLALLLLAPSLLLLLLLLLlLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLA 349


                 ....*...
gi 767958514 333 GFIFYMFH 340
Cdd:cd06174  350 GFLLAATF 357
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 18-339 1.00e-19

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 90.36  E-value: 1.00e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  18 GLIQGVKGLLSFLSAPLIGALSDVWGRKPFLLGTVFFTCFPIPLMRI--SPWWYFAMISVSGVF-SVTFSVIFAYVADVT 94
Cdd:cd17329   38 GLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFahSPWLFAIALVLTGFGgGLFEPASEAMIADVT 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  95 QEHERSTAYGWVSATFAASLVSSPAIGAYLsasYGDSLVVLVATVVALLDICFILVA--VPESLPEKMRPvswgaqiswK 172
Cdd:cd17329  118 TPENRTRAFSLLYWAINLGVAIGPLLGGLL---LLYSFRLLFLAAAVLFLLAALVLLflLPETRPKRRAA---------E 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 173 QADPFASLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQVIGFGSVKIAAFIAMVGILSIVAQTaFLSILMRSLG 252
Cdd:cd17329  186 KTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQF-PVARLVERFR 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 253 NKNTVLLGLGFQMLQLAWYGFGSQAWMMWAAGTVAAM-SSITFPAISALVSRNAESDQQGVAQGIITGIRGLCNGLGPAL 331
Cdd:cd17329  265 LRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLgEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLV 344


                 ....*...
gi 767958514 332 YGFIFYMF 339
Cdd:cd17329  345 GGLLLDLL 352
MFS_1 pfam07690
Major Facilitator Superfamily;
18-329 5.86e-18

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 84.78  E-value: 5.86e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514   18 GLIQGVKGLLSFLSAPLIGALSDVWGRKPFLLGTVFFTCFP--IPLMRISPWWYFAMISVSGVF-SVTFSVIFAYVADVT 94
Cdd:pfam07690  35 GLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGllLLLFASSLWLLLVLRVLQGLGaGALFPAALALIADWF 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514   95 QEHERSTAYGWVSATFAASLVSSPAIGAYLSASYGDSLVVLVATVVALldICFILVAVPESLPEKMRPVSWGAqiswKQA 174
Cdd:pfam07690 115 PPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSL--LAAVLLLLPRPPPESKRPKPAEE----ARL 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  175 DPFASLKKVGKDstVLLICITVFLSYLPEAGQYSSFFLYLRQVIGFGSVKIAAFIAMVGILSIVAQtAFLSILMRSLGNK 254
Cdd:pfam07690 189 SLIVAWKALLRD--PVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGR-LLLGRLSDRLGRR 265

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767958514  255 NTVLLGLGFQMLQLAWYGF----GSQAWMMWAAGTVAAMSSITFPAISALVSRNAESDQQGVAQGIITGIRGLCNGLGP 329
Cdd:pfam07690 266 RRLLLALLLLILAALGLLLlsltLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
 15-339 6.87e-18

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 85.02  E-value: 6.87e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  15 LMNGLIQGVKGLLSFLSAPLIGALSDVWGRKPFLLGTVFFTCFPIPLMRISPWWYFAMIS--VSGVFSVTFSVIFAYVAD 92
Cdd:cd17389   64 LFGGLIGSLFSLLQFLSSPITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSriVGGISKGNVSLSTAIVAD 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  93 VTQEHERSTAYGWVSATFAASLVSSPAIGAYLS------ASYGDSLVVLVATVVALLDICFILVAVPESLPEKMRPVSWG 166
Cdd:cd17389  144 VTSPKKRSKGMALIGVAFSLGFIIGPMIGAYFAsftrslGEVFFSMPALFALVLALADLLFIFFFLPETLPSNLRRLGLV 223

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 167 aqiswkqadpfaslkkvgkdstvllicitVFLSYLPEAG-QYSSFFLyLRQVIGFGSVKIAAFIAMVGILSIVAQTAFLS 245
Cdd:cd17389  224 -----------------------------YFLYLFLFSGlEFTLTFL-THQRFQYTSMQQGKMFFFIGIIMALVQGGYVR 273

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 246 ILmRSLGNKNTVLLGLGFQMLQLAWYGFGSQAWMMWAAGTVAAM-SSITFPAISALVSRNAESDQQGVAQGIITGIRGLC 324
Cdd:cd17389  274 RI-KPGKEKKAVLQGLILLIPAFLLIGWASSVTVLYAGLFLYSFaAATVVPCLTTLVSGYGSDDQKGTVMGIFRSLGALA 352

                        330
                 ....*....|....*
gi 767958514 325 NGLGPALYGFIFYMF 339
Cdd:cd17389  353 RALGPIVACTVYWLA 367
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
18-385 7.51e-17

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 82.26  E-value: 7.51e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  18 GLIQGVKGLLSFLSAPLIGALSD----VWG-RKPFLLGTVFFTCFPIPLMRISP--------WWYFAMISVSGVFSVTFS 84
Cdd:COG2211   49 GLILLVARLWDAITDPLIGALSDrtrtRWGrRRPWILIGAIPLALSFVLLFTAPdlsptgklIYALVTYLLLGLAYTLVN 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  85 VIF-AYVADVTQE-HERSTAYGWVSATFAASLVSSPAIGAYLSASYGDSLVVLVATVVALLDICFILVA------VPESL 156
Cdd:COG2211  129 IPYsALGAELTPDyEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDAALGYRLTALIFAVLGLLAFlltffgTKERP 208

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 157 PEKMRPVSWgaqiswkqadpFASLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQVIGFGSVKIAAFIAMVGILS 236
Cdd:COG2211  209 VPEEEKVSL-----------KESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAA 277

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 237 IVAqTAFLSILMRSLGNKNTVLLGLGFQ---MLQLAWYGFGSQAWMMWAAGTVAAMSSITFPAISALVSRNAESDQQ--- 310
Cdd:COG2211  278 LLG-APLWPRLAKRFGKKKAFIIGLLLAalgLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWktg 356

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767958514 311 ----GVAQGIITGIRGLCNGLGPALYGFIfymfhveLTELGPKLNSNNVPLQGAVIPGPPFLFGACIVLMSFLVALFIP 385
Cdd:COG2211  357 rrreGLYFGIFTFAIKLGQALAGALAGLL-------LALFGYVAGAAQSPSALTGIRLLFFLLPAVLLLLAALLLLFYP 428
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 18-344 6.10e-15

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 76.11  E-value: 6.10e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  18 GLIQGVKGLLSFLSAPLIGALSDVWGRKPFLLGT-------VFFTCFPIPLMRISPWWYFAMISVSGVFSVTFSVIF-AY 89
Cdd:cd06173   37 GLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILAdllrallAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARqAL 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  90 VADVTQEHERSTAYGWVSATFAASLVSSPAIGAYLSASYGDSLVVLVATvvalldICFILVAVPESLPEKMRPVSWGAQI 169
Cdd:cd06173  117 LPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINA------LSFLLSALLLLFIRRPPPAAPGESS 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 170 SWKQADPFASLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQVIGFGSVKIAAFIAMVGILSIVAqTAFLSILMR 249
Cdd:cd06173  191 SLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLG-ALLLGRLSK 269

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 250 SLGNKNTVLLGLGFQMLQLAWYGFGSQAWMMWAAGTVAAMSSITF-PAISALVSRNAESDQQGVAQGIITGIRGLCNGLG 328
Cdd:cd06173  270 RRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFnVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLG 349

                        330
                 ....*....|....*.
gi 767958514 329 PALYGFIFYMFHVELT 344
Cdd:cd06173  350 ALLAGLLADALGLSAV 365
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 18-336 1.21e-14

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 74.89  E-value: 1.21e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  18 GLIQGVKGLLSFLSAPLIGALSDVWGRKPFLLGTVFFTCFPIPLMRISPWWYFAMIS--VSGVF-SVTFSVIFAYVADVT 94
Cdd:cd17324   37 GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLAraLAGLAhGGFWAIAAAYAADLV 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  95 QEHERSTAYGWVSATFAASLVSSPAIGAYLSASYGDSLVVLVATVVALLDICFILVAVPESLPEKMRPVSwgaqiswkqa 174
Cdd:cd17324  117 PPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKPGSLG---------- 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 175 dPFASLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQVIGFGSVKIAAFIAMVGILSIVAQTAFLSILMRslGNK 254
Cdd:cd17324  187 -LLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADR--GGR 263

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 255 NTVLLGLGFQMLQLAWYGFGSQAWMMWAAGTV--AAMSSITFPAISALVSRNAEsDQQGVAQGIITGIRGLCNGLGPALY 332
Cdd:cd17324  264 RALLIALLLLAAALLLLTLLGPSPLLLLVGLVlwGLGFFAAHSALQTRVLRLAP-EARGLASSLYLAAYNLGGALGAALG 342


                 ....
gi 767958514 333 GFIF 336
Cdd:cd17324  343 GLVL 346
MFS_SLC46 cd17386
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ...
 23-380 3.96e-14

Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340944 [Multi-domain]  Cd Length: 360  Bit Score: 73.47  E-value: 3.96e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  23 VKGLLSFLSAPLIGALSDVWGRKP--------FLLGTVFFTCFPIPLMRISPWWYF---AMISVSGVFSVTFSVIFAYVA 91
Cdd:cd17386   38 MGSIPPLFSSLFLGSWSDRYGRKPpllmslvgLLLSSLILVLIVYFTTVPSVWWFYlsaIPLALFGGFTAFLSASFAYIS 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  92 DVTQEHERSTAYGWVSATFAASLVSSPAIGAYLSASYGDSLVVLVATVVALLDICFILVAVpeslpekmrpvswgaqisw 171
Cdd:cd17386  118 DISSEKKRTYRMAILEVALGLGGFLGSLLSGHLFKALGYAWSFSISAALLLIALLYILFFL------------------- 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 172 kqadpfaslkkvgkdSTVLLICITVFLSYLPEAGQYSSFFLYLRQVIGFGSVKIAAFIAmVGILSIVAQTAFLSILMRSL 251
Cdd:cd17386  179 ---------------TLLILLLLAAFLTIFVLSGESDVLYLFVLEKFAWNVKDFSYFST-LGSLIYLTGMLGGVLLLRCL 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 252 GNKNTV---LLGLGFQMLQLAWYGFGSQAWMMWAAGTVAAMSSITFPAISALVSRNAESDQQGVaqgiITGIRGLCNGLG 328
Cdd:cd17386  243 LKMSDStlaMLGLASHILSSLLFAFATNTWMMYLAAVVGMFNGIVGPMIRSILSKLVPKSEQGK----IFSLLSVLESLS 318

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|..
gi 767958514 329 PALYGFIFymfhveltelgpklnSNNVPLQGAVIPGPPFLFGACIVLMSFLV 380
Cdd:cd17386  319 PLVASPIY---------------NNIYKATLTTFPGFFFLLSAGLLLIPVIL 355
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 16-336 3.12e-13

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 70.71  E-value: 3.12e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  16 MNGLIQGVKGLLSFLSAPLIGALSDVWG-RKPFLLGTVFFTCFPIPLMRI-SPWWYFamIS-VSGVFSVTFSVIFAYVAD 92
Cdd:cd17331   36 VFGYLQTTFSVLQLVGGPLFGRFGDLFGpRAALVLSFLSSALSYLLLAFAsSVPMLF--LSrLPSVFMHAMQAAQMVVTD 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  93 VTQEHERSTAYGWVSATFAASLVSSPAIGAYLSASYGDSLVVLVATVVALLDICFILVAVPES-----LPEKMRPVSWGA 167
Cdd:cd17331  114 LTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVGSLLSIVLVILLIPSNtkskrEKEAKESASPPS 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 168 QISWKQADPFASLKKVGKdstvllICITVFLSYLPEAGQYSSFFLYLRQVIGFGSVKIAAFIAMVGILSIVAQTAFLSIL 247
Cdd:cd17331  194 VFNLKEILRLLRLPGVAF------LLLVKLLSGLPIGMFQSMFSLVAMDFFGLTPEENGYLMSYAGVLGMVVQGLLVGPL 267

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 248 MRSLGNKNTVLLGLGFQMLQLAWYGF-GSQAWMMWAAGTVAAMSSITFPAISALVSRNAESDQQGVAQGIITGIRGLCNG 326
Cdd:cd17331  268 TKRFGERSLLKLSVALLAIGYLLLAFvTTVWQLLVLLLPLVIGGSVLYTVITSLLTKAVPPEDTGTALGLSHALFSLVRT 347

                        330
                 ....*....|
gi 767958514 327 LGPALYGFIF 336
Cdd:cd17331  348 VSPTIGGALL 357
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
18-335 4.28e-12

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 67.19  E-value: 4.28e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  18 GLIQGVKGLLSFLSAPLIGALSDVWGRKPFLLGTVFFTCFPIPLMRISPWWYFAMIS--VSGV-FSVTFSVIFAYVADVT 94
Cdd:COG0738   46 GLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLAlfLLGLgLGLLDVAANPYVAALG 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  95 QEHeRSTAYGWVSATFAASLVSSPAIGAYLSASYGDSLVVLVATVVALLDICFILVAVPESLPEKMRPVSwgaqiswKQA 174
Cdd:COG0738  126 PET-AASRLNLLHAFFSLGALLGPLLGGLLILLGLSLSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEE-------EAA 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 175 DPFASLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQVIGFgSVKIAAFIAMVGILSIVAQTAFLSILMRSLGNK 254
Cdd:COG0738  198 GSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGL-SEATAALGLSLFWGGMTIGRFLGGFLLKRFGPV 276

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 255 NTVLLGLGFQMLQLAWYGFGSQAWM-MWAAGTVAAMSSITFPAISALVSRNAESDQQGVAqGIITGIRGLCNGLGPALYG 333
Cdd:COG0738  277 RLLRLSALLAAVGLLLALLAPGPWLaLIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAV-SAVLIMGIVGGAIGPPLIG 355


                 ..
gi 767958514 334 FI 335
Cdd:COG0738  356 FL 357
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 30-385 8.73e-12

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 66.45  E-value: 8.73e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  30 LSAPLIGALSDVWGRKPFLLGTVFFTCFPIPLMRISPWWYFAMIS--VSGVFSVTFSVIFAYVADVTQEHERSTAYGWVS 107
Cdd:cd17504   46 VSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGraLQGIGGAVFPLAFALVREEFPPERVPVAQGILS 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 108 ATFAASLVSSPAIGAYLSASYGDSLVVLVATVvalldICFILVAVPESLPEKM--RPVSWGAQIswkqadpfaslkkvgk 185
Cdd:cd17504  126 ATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAP-----VAVLLAALVPLIDLRLlrRRNVLLANI---------------- 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 186 dsTVLLICITVFLSYlpeagQYSSFFLYLRQVIGFG-SVKIAAFIAMVGILSIVAQTAFLSILMRSLGNKNTVLLGLGFQ 264
Cdd:cd17504  185 --TALLAGFGMFMVF-----QLLPQLLQLPTPTGFGlGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVIS 257

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 265 MLQLAWYGF-GSQAWMMWAAGTVAAM-SSITFPAISALVSRNAESDQQGVAQGIITGIRGLCNGLGPALYGFIFYMFHVE 342
Cdd:cd17504  258 AVGLLLLALlHSSLWALVVALLLIGIgLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAILTTYTVS 337

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 767958514 343 LTelgpklnSNNVPLQGAVIPGppFLFGACIVLMSFLVALFIP 385
Cdd:cd17504  338 IT-------SGGVPTEGAYVLA--FLIGAALALAALLLSLLIP 371
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 18-129 3.26e-11

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 64.17  E-value: 3.26e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  18 GLIQGVKGLLSFLSAPLIGALSDVWGRKPFLLGTVFFTCFPIPLMRISPWWYFAMIS--VSGVFSVTFSVIFAYVADVTQ 95
Cdd:cd17390   34 GLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSriPLGIFKHTQSLCKAYLSDLVS 113

                         90       100       110
                 ....*....|....*....|....*....|....
gi 767958514  96 EHERSTAYGWVSATFAASLVSSPAIGAYLSASYG 129
Cdd:cd17390  114 EQERSRVLGRFNAASSLGFILGPVVGGHLAETDG 147
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 33-385 4.13e-10

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 61.03  E-value: 4.13e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  33 PLIGALSDVWGRKP-FLLGTVFFT-----CFpiplMRISPWWYFAMISVSGVF-SVTFSVIFAYVADVTQEHERSTAYGW 105
Cdd:cd17321   49 LLAGRLGDRFGRKRvFLIGLALFGlasllCA----LAPSLAFLIAARALQGIGaAAIMPASLALIAATFPGERRGRALGL 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 106 VSATFAASLVSSPAIGAylsasygdslvvlvatvvalldicfILVAVpeslpekmrpVSWGAqISWKQAdPFASLKKVGK 185
Cdd:cd17321  125 WGAVVGIGAALGPLLGG-------------------------LLLEL----------FGWRW-IFLINV-PIGLVALLLA 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 186 dSTVLLICITVFLSYLPEAGQYSSFFLYLRQVIGFGSVKIAAFIAMVGILSIVAqTAFLSILMRSLGNKNTVLLGLGFQM 265
Cdd:cd17321  168 -RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVA-APLAGRLADRFGPRLVLVAGLLLTA 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 266 LQLAWYGFGSQAWMMW--AAGTVAAM--SSITFPAISALVSRNAESDQQGVAQGIITGIRGLCNGLGPALYGFIFYM-FH 340
Cdd:cd17321  246 VGLLLLALLGADSSVWllLPGLVLLGlgLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLTAgLS 325

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
gi 767958514 341 VELTELGPKLNSNNVPLQGAVIPGPPFLFGACIVLMSFLVALFIP 385
Cdd:cd17321  326 ANLGDSGVAALLSAAAAAFAAGFHLAFLVAAALALLAALLALLLP 370
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
18-385 1.01e-09

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 59.88  E-value: 1.01e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  18 GLIQGVKGLLSFLSAPLIGALSDVWGRKPFLLGTVFFT---CFPIPLMRiSPWWYFAMISVSGVF-SVTFSVIFAYVADV 93
Cdd:COG2271   48 GLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWglaTLLFGFAT-SFWQLLLLRFLLGLGeAGFFPAALKLIAEW 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  94 TQEHERSTAYGWVSATFAASLVSSPAIGAYLSASYGdslvvlvatvvalLDICFILVAVPeslpekmrPVSWGAqiswkq 173
Cdd:COG2271  127 FPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFG-------------WRAAFLILGLP--------GLLLAL------ 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 174 adpfaslkkvgkdSTVLLICITVFLSYLPEAGQYSSFFLYLRQVIGFGSVKIAAFIAMVGILSIVAqTAFLSILMRSLG- 252
Cdd:COG2271  180 -------------LRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVG-SLLGGWLSDRLGr 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 253 -NKNTVLLGLGFQMLQLAWYGFGSQAWMMWAAGTVAAMSSI-TFPAISALVSRNAESDQQGVAQGIITGIRGLCNGLGPA 330
Cdd:COG2271  246 rRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGgAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPL 325

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767958514 331 LYGFIFYMFHveltelgpklnsnnvplqgaviPGPPFLFGACIVLMSFLVALFIP 385
Cdd:COG2271  326 LVGYLLDATG----------------------YQAAFLLLAALALLAALLALLLL 358
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 23-340 2.40e-09

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 58.82  E-value: 2.40e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  23 VKGLLSFLSAPLIGALSDVWG-RKPFLLGTVFFT--CFPIPLMRISPWWYFAMISVSGVFSVTFS-VIFAYVADVTQEHE 98
Cdd:cd17355   46 VGLLAFGLAQPFVGRLLDRFGpRRVMLLGLLLLAagLVLLALATSLWQLYLLWGLLGGGGAGTLAaVAFATVAAWWFERR 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  99 RSTAYGWVSATFAASLVSSPAIGAYLSASYGDSLVVLVATVvalldicFILVAVPESLPEKMRPVSWGAQISWKQAD--- 175
Cdd:cd17355  126 RGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLAL-------LALLVLVPVLLLLRRRPADLALRAYDDASpas 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 176 PFASLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQvIGFGSVKIAAFIAMVGILSIVAQTaFLSILMRSLGNKN 255
Cdd:cd17355  199 PGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLAD-RGISPAAAAVALALIGLFNIVGRL-LSGWLGDRYSPRR 276

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 256 TVLLGLGFQMLQLAWYGFG-SQAWMMWAAGTVAAMSSI-TFPAISALVSRNAESDQQGVAQGIITGIRGLCNGLGPALYG 333
Cdd:cd17355  277 LLAASYALRALGLALLLLLpFPPLALLLFAALFGLGWGaTVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGG 356


                 ....*..
gi 767958514 334 FIFYMFH 340
Cdd:cd17355  357 LLYDRTG 363
MFS_MFSD6 cd17335
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...
 18-335 2.41e-09

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340893 [Multi-domain]  Cd Length: 375  Bit Score: 58.75  E-value: 2.41e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  18 GLIQGVKGLLSFLSAPLIGALSDVWG-RKPFLLGTVFFTC---FPIPLMRISPWWYFAMISVSGVFSVTFSVIFAYVAdV 93
Cdd:cd17335   35 GILIGIRPFVRFLSAPLWGALADRFGkRKALLLLSLLAAVlffLSLFFVAQIFWLLLLLVILGAFFSAPVVPLVDSIT-L 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  94 TQEHERSTAYG----WVSATFAAslvSSPAIGAYLSASYGDslvvlvatvvALLDICFI------LVAVPESLPEKMRPV 163
Cdd:cd17335  114 QYLGEERERYGkqrlWGSIGFGI---AALLVGILIDRSSTY----------KNYTIAFYvfavlmLLALLLALKFPFRPK 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 164 SWGAQISWKQadpfasLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQVigfGSVKIAAFIAM-VGILSIVAQTA 242
Cdd:cd17335  181 HPEPNENTGG------LLALLRNPRVLAFLLVAFLMGFGHGLIYSFLFWHLQDL---GGSKTLIGLLWtVGVVSEIPFFF 251

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 243 FLSILMRSLGNKNTVLLGLGFQMLQLAWYGFGSQAWMMwaaGTVAAMSSITF----PAISALVSRNAESDQQGVAQGIIT 318
Cdd:cd17335  252 FSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLV---LPIELLHGLTFalvwAAAVSYASAAAPPGLRATAQGLLQ 328

                        330
                 ....*....|....*..
gi 767958514 319 girGLCNGLGPALYGFI 335
Cdd:cd17335  329 ---GLYFGLGGGLGSLI 342
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
18-336 9.26e-09

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 56.81  E-value: 9.26e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  18 GLIQGVKGLLSFLSAPLIGALSDVWG-RKPFLLGTVFFTcfpIPLM----RISPWWYFAMISVSGVFS-VTFSVIFAYVA 91
Cdd:COG2223   43 GLLFAIPVLVGALLRIPLGFLVDRFGpRRVLLIGLLLLG---IGLLllalAVSYWLLLLLGLLLGIGGgGSFAVGIALVS 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  92 DVTQEHERSTAYGWVSATFAASLVSSPAIGAYLSASYGDSLVVLVATvvalldICFILVAVPESLPEKMRPVSWGAqisw 171
Cdd:COG2223  120 KWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILG------ILLLVVAVLAWLFLRDPPAGAAA---- 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 172 KQADPFASLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQVIGFGSVKIAAFIAMVGILSIVAqTAFLSILMRSL 251
Cdd:COG2223  190 AAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALG-RPLGGWLSDRI 268

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 252 GNKNTVLLGLGFQMLQLAW--YGFGSQAWMMWAAGTVAAMSSITFPAISALVSRNAESDQQGVAQGIITGIRGLCNGLGP 329
Cdd:COG2223  269 GGRRVLLIVFALMALGLLLlaLALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGP 348


                 ....*..
gi 767958514 330 ALYGFIF 336
Cdd:COG2223  349 LLFGALL 355
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 30-318 1.06e-08

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 56.81  E-value: 1.06e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  30 LSAPLIGALSDVWGRKPFLL-GTVFFTCF-PIPLMRISPWWYFAM-----ISVSGVFSVTFSVIfayvADVTQEHERSTA 102
Cdd:cd17473   50 LFAPLAGWLADRFGRKRLLIaGLLLYGIGgVAGLFLDSLYALLASrallgIGVAGIMTLATALI----GDYFEGEERAKM 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 103 YGWVSATFAASLVSSPAIGAYLSAS--------YGDSLvvlvatvvalldICFILVAVpeSLPEKMRPVSwgaqiswKQA 174
Cdd:cd17473  126 LGLQSAAMSLGGVVFLLLGGALAEIgwrapflvYLLAL------------PVLILVLL--FLPEPARKSK-------SAA 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 175 DPFASLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQVIGFGSVKIAAFIAMVGILSIVAQTAFlSILMRSLGNK 254
Cdd:cd17473  185 SPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLF-GRLKRRLGKR 263

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767958514 255 NTVLLGLGFQMLQLAWYGFGSQAWMMWAAGTVAAM-SSITFPAISALVSRNAESDQQGVAQGIIT 318
Cdd:cd17473  264 RLLAIGFALMALGFLLLALASGLWVVLLGAILAGLgFGLLLPTLNSWAMSLVPPELRGRAMGIVT 328
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 18-383 1.38e-08

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 56.45  E-value: 1.38e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  18 GLIQGVKGLLSFLSAPLIGALSDVWGRKPFLLGTVFFTCFPIPLMRI--SPWWYFAMISVSGV-FSVTFSVIFAYVADVT 94
Cdd:cd17489   34 GLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLatSVALLLVLRLIHGIgWGAFTTAAATLVADII 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  95 QEHERSTAYGWVSATFAASLVSSPAIGAYLSASYGDSLVVLVATVvalldicFILVAVPESLPEKMRPVSWGAQISWKQA 174
Cdd:cd17489  114 PPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAV-------LALLALLLVFLVKDPPPVAAEEAEAGTR 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 175 DPFASLKKVgkdstVLLICITVFLSYLPEAGQYSSFFLYLRQVigfGSVKIAAFIAMVGILSIVAQTAFLSILMRsLGNK 254
Cdd:cd17489  187 AFRRLVEKK-----VLPPALILFLASIAYGAISTFLPLYAAER---GISNAGLFFTVYAIALLLSRPFSGKLSDR-KGPK 257

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 255 NTVLLGLGFQMLQLAWYGFGSQAWMMWAAGTVAAMS-SITFPAISALVSRNAESDQQGVAQGIITGIRGLCNGLGPALYG 333
Cdd:cd17489  258 TVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGfGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLG 337

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|
gi 767958514 334 FIFYMFHveltelgpklnsnnvplqgaviPGPPFLFGACIVLMSFLVALF 383
Cdd:cd17489  338 LVAELFG----------------------YRAMFLLAAVVVLLALVLYIF 365
MFS_1_like pfam12832
MFS_1 like family; This family contains proteins related to the MFS superfamily.
 18-339 7.28e-08

MFS_1 like family; This family contains proteins related to the MFS superfamily.


Pssm-ID: 432817 [Multi-domain]  Cd Length: 362  Bit Score: 54.17  E-value: 7.28e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514   18 GLIQGVKGLLSFLSAPLIGALSDVWGR--KPFLLGTVFFTCFPIPLMRISP----WWYFAMISVSGVFSVTFSVIFAyVA 91
Cdd:pfam12832  37 GLITAILPLTRILAPPIWGWLADRTGKrkAVVRLASILAAVLFLSVLFIPIsltfWWLALLVVLFSFFWNAILPQFE-VA 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514   92 DVTQEHERSTAYG----WVSATFAASLVSSPAIGAYLSASYGDSLVVLvatvvalldICFILVAVPESLPEKMRPVSWGA 167
Cdd:pfam12832 116 TLQHLGEKRKDYGrqrlWGSVGFALSVFGLGALFDHYSVGLLPSVLFY---------LFAALMLLSLLLPLAPPEMEYES 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  168 QISwkqadPFASLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQViGFGSVKIAAFIAmVGILSIVAQTAFLSIL 247
Cdd:pfam12832 187 KGG-----SKAVFWNLLKQPEVIIFFLAAFLLGFSHGPFYTFLFLYLENL-GASNTLLGALWA-LGVVAEIPLFFYAHRL 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  248 MRSLGNKNTVLLGLGFQMLQLAWYGFG-SQAWMMWAAGTVAAMS-SITFPAISALVSRNAESDQQGVAQGIITGIR-GLC 324
Cdd:pfam12832 260 LRRFGHRNLLIIALLLTALRWLLYAFFvENPWLVLPIQFLHAISfGLTHAAAIEYVRRIFPGSLQGTGQALYSGLYfGLG 339

                         330
                  ....*....|....*
gi 767958514  325 NGLGPALYGFIFYMF 339
Cdd:pfam12832 340 GALGSLIGGQLWDLF 354
BtlA COG2270
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ...
 18-340 1.56e-07

MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];


Pssm-ID: 441871 [Multi-domain]  Cd Length: 424  Bit Score: 53.23  E-value: 1.56e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  18 GLIQGVKGLLSFLSAPLIGALSDVWG-RKPFLLGTVFFTCFPIPLM---RISPWWYFAMISVSGVFSVTFSVIF--AYVA 91
Cdd:COG2270   55 GYALAIAGLLVALLAPVLGAIADRSGrKKPFLAFFTLLGVLATAALffvAPGGLWLGLLLFVLANIGFEGSLVFynAFLP 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  92 DVTQEHERST--AYGW--------VSATFAASLVSSPAIGAYLSASYGDSlvvlvatvvalldICFILVA---------- 151
Cdd:COG2270  135 DIATPEEIGRvsGLGWalgylggvLLLLINLALFLKPEAFGLPDAGEAVR-------------ISFLLTAlwwllfalpl 201

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 152 ---VPESLPEKMRPVSWGAQISWKQAdpFASLKKVGKDSTVL--LICITVFLSYLpeAGQYSSFFLYLRQVIGFGSVKIA 226
Cdd:COG2270  202 flfLPERPRPGPAPPRGAVRAGFREL--RRTLRELRRYRDLLrfLLAYFFYRDGV--QTVIAFAGIYAAGVLGFSTTELI 277

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 227 AFIAMVGILSIVAQTAFlSILMRSLGNKNTVLLGLGFQMLQLAWYGFGSQAWMMWAAGTVAAMSSITFPAIS-ALVSRNA 305
Cdd:COG2270  278 VFGLLVQIVAALGALLF-GRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAFWILGLLIGLVMGGIQALSrSLLARLI 356

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
gi 767958514 306 ESDQQGVAQGI------ITGIrglcngLGPALYGFIFYMFH 340
Cdd:COG2270  357 PPGREAEFFGLyalsgkAASF------LGPLLFGLVTQLTG 391
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 18-336 7.36e-07

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 51.06  E-value: 7.36e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  18 GLIQGVKGLL-SFLSAPLiGALSDVWGRKP-FLLGTVFFTC-FPIPLMRISPWWYFAMISVSGVFSVTfSVIFAYVADVT 94
Cdd:cd17472   35 GLALGIYGLTqAIFQIPF-GLLSDRIGRKPvILFGLLLFIAgSLLAAYATSIYGLILGRALQGSGAIS-SVVMALLADLT 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  95 QEHERSTAYGWVSATFAASLVSSPAIGAYLSASYGDSLVVLVATVVALLDICFILVAVPESLPEKmrpvswgaQISWKQA 174
Cdd:cd17472  113 REENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPDPPKIV--------QISEKEK 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 175 dpfASLKKVGKDSTVLLICITVFLSYLpeagQYSSFF----LYLRQVIG--------FGSVKIAAFIAMVgILSIVAQTA 242
Cdd:cd17472  185 ---KKLKKLLKNKRLLRLDFSIFILHF----VLMAFFyilpLLLTQLGGgkgqlwkvYLPAILIGFILMV-PFVIYAEKK 256

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 243 F-LSILMRSlgnkNTVLLGLGFQMLqlawyGFGSQAWMMWAAGTVAAMSSITF--PAISALVSRNAESDQQGVAQGIITG 319
Cdd:cd17472  257 GkMKQVFVS----SILLIAVGFLLL-----LFAATSLWLLIIGLIIFFIGFNLleALLPSLVSKIAPKEYRGTAMGIYNT 327

                        330
                 ....*....|....*..
gi 767958514 320 IRGLCNGLGPALYGFIF 336
Cdd:cd17472  328 SQFLGSFLGGALGGLLW 344
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 30-336 2.64e-06

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 49.11  E-value: 2.64e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  30 LSAPLIGALSDVWGRKPFLL-GTVFFTCFP-IPLMRISPWWYFAMISVSGVFSVTFSVI-FAYVADVTQEHERSTAYGWV 106
Cdd:cd17474   49 VLMPVAGVLADRFGRKKVLLpGLLLFGIGGlLCGLSDSFALLLAGRALQGIGAAGLGPLaLTLIGDLFEGGERAKAMGLY 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 107 SATFAASLVSSPAIGAYLSAsygDSLVVLVATVVALLDICFILVAV-PESLPEKMRPVSWGAQISWKQADPFASLKKVGK 185
Cdd:cd17474  129 EAALGLGIAVGPLLGGLLAA---ISWRYPFFLLAALIPVAFLAILFlLPEPKEKAKSSSATKLRDLKKALRGRGLLTFLV 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 186 DSTVLLICITVFLSYLPeagqyssffLYLRQVIGFGSVKIAAFIAMVGILSIVAQTAFLSILMRSLGNKNTVLLGLGFQM 265
Cdd:cd17474  206 SAFLYFFLYFAFLTYLP---------FLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYA 276

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767958514 266 LQLAWYGFGSQAWMMWAAGTVAAMSS-ITFPAISALVSRNAESDQQGVAQGIITGIRGLCNGLGPALYGFIF 336
Cdd:cd17474  277 LSLLLLGFVPSLALLLIAIVLFGLGLgLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLL 348
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
18-129 3.77e-06

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 48.72  E-value: 3.77e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  18 GLIQGVKGLLSFLSAPLIGALSDVWGRKPFLLGT---VFFTCFPIPLMRISPWWYFAMISVSGVF-SVTFSVIFAYVADV 93
Cdd:COG2223  244 GLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVfalMALGLLLLALALGSLWLFLVLFLLLGLAlGGGNGAVFALVPDI 323

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 767958514  94 TQEHERSTAYGWVSATFAASLVSSPAIGAYLSASYG 129
Cdd:COG2223  324 FPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATG 359
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 26-129 4.34e-06

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 48.69  E-value: 4.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  26 LLSFLSAPLIGALSDVWGRKP-FLLGTVFFTCFPIPLM-RISPWWYFAMISVSGVF-SVTFSVIFAYVADVTQEHERSTA 102
Cdd:cd17370  245 LVYALAAYPAGRLSDRIGRKKlLILGYLSLALAYLGFAlGSSLWLLLLGFILWGLYmGAQESIERAAVADLVPAELRGTA 324

                         90       100
                 ....*....|....*....|....*..
gi 767958514 103 YGWVSATFAASLVSSPAIGAYLSASYG 129
Cdd:cd17370  325 YGLFNTVVGIGWLLASLIAGYLWDLIS 351
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 34-336 8.10e-06

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 47.57  E-value: 8.10e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  34 LIGALSDVWGRKPFLL-GTVFF--TCFpIPLMRISPWWYFAMISVSGVFSVTFSVI-FAYVADVTQEHERSTAYGWVSAT 109
Cdd:cd17320   53 LYGPLSDRFGRRPVLLaGLLLFilASL-LCALASSIEQLLIARFLQGLGAAAGSVVaRAIVRDLYSGAELAKIFSLLMMI 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 110 FAASLVSSPAIGAYLSASYGDSLVVLVATVVALldICFILVA--VPESLPEKMRPVSWGAQiswkqadpFASLKKVGKDS 187
Cdd:cd17320  132 LAIAPALAPLLGGLLLLFFGWRAIFVFLALLGL--LLLLLVLlfLPETLPEEKRKPLLSSL--------LRAYKRVLKNR 201

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 188 TVLLICITVFLSYLPEAGQYS-SFFLYLrQVIGFGSVKIAAFIAMVGILSIVAqTAFLSILMRSLGNKNTVLLGLGFQ-- 264
Cdd:cd17320  202 RFLGYALALGLSFAGLFAYLAaAPFIYI-EQLGLSPAQFGLLFALNAIALILG-SLLNGRLVRRFGPRRLLRLGLLLLla 279

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767958514 265 ----MLQLAWYGFGSQAWMMWAAGTVAAMSSITFPAISALVSRnAESDQQGVAQGIITGIRGLCNGLGPALYGFIF 336
Cdd:cd17320  280 aalvLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALE-PFPHVAGTASALLGFLQFLIGALAGALVGLLP 354
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
 9-131 3.47e-05

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 45.98  E-value: 3.47e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514   9 FSQHTFLMNGLIQGVkglLSFLSAPLIGALSDVWGRKP-FLLGTVFFTCFPIPLM-----RISPWWYFAMISVSGVF-SV 81
Cdd:cd17369  261 VDRSTVLLAVLIASV---VAAITIPLFGWLSDRVGRRPvYLAGALLAALFAFPFFwlldtGSTWLIVLAAVVVLGVLhGM 337

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 767958514  82 TFSVIFAYVADVTQEHERSTAYGwVSATFAASLVSS--PAIGAYLSASYGDS 131
Cdd:cd17369  338 MYGPQAAFLAELFPTRVRYTGAS-LGYQLGAILGGGfaPLIATALVAATGSW 388
MFS_1 pfam07690
Major Facilitator Superfamily;
192-339 1.75e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 43.56  E-value: 1.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  192 ICITVFLSYLPEAGQYSSFFLYLRQVIGFGSVKIAAFIAMVGILSIVAQtAFLSILMRSLGNKNTVLLGLGFQMLQLAWY 271
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQ-PLAGRLSDRFGRRRVLLIGLLLFALGLLLL 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767958514  272 GFGSQAWMMWAAGTVAAM-SSITFPAISALVSRNAESDQQGVAQGIITGIRGLCNGLGPALYGFIFYMF 339
Cdd:pfam07690  80 LFASSLWLLLVLRVLQGLgAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF 148
MFS_MFSD6L cd17479
Major facilitator superfamily domain-containing protein 6-like and similar transporters of the ...
 179-336 2.05e-04

Major facilitator superfamily domain-containing protein 6-like and similar transporters of the Major Facilitator Superfamily; Major facilitator superfamily domain-containing protein 6-like (MFSD6L) protein family includes a group uncharacterized proteins similar to human major facilitator superfamily domain-containing protein 6 (MFSD6). MFSD6 is also called Macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. The MFSD6L family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341032 [Multi-domain]  Cd Length: 376  Bit Score: 43.45  E-value: 2.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 179 SLKKVGKDSTVLLICITVFLSYLPeAGQYSSFFLYLRQVIGFGSVKIAAFIAmVGILSIVAQTAFLSILMRSLGNKNTVL 258
Cdd:cd17479  195 GLRLLGGDGRAILYALTVFLVGFV-GSTVQNFLFWLMQDKGGSELHMGLSIA-LALLSEILMSFFGNWLLRKLGHAGCVV 272

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767958514 259 LGLGFQMLQLAWYGFGSQAWMMWAAGTVAAMSSITF-PAISALVSRNAesdQQGVAQGIITGIRGLCNGLGPALYGFIF 336
Cdd:cd17479  273 LGLLGLGAQLLYYSFLWTPWAVLPIELLHAFSNGALwWAVNSQVEFLA---SPGMERSLQLVLRALYYGIGFALGSFVS 348
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 18-129 2.11e-04

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 42.88  E-value: 2.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  18 GLIQGVKGLLSFLSAPLIGALSDVWGRKP-FLLGTVFFTCFPIPL-MRISPWWYFAMISVSGVF-SVTFSVIFAYVADVT 94
Cdd:COG0477   52 GWIVSAYLLGRAIGLLLFGRLGDRYGRKRvLLIGLLLFGLASLLCgLAPSPELLIAARALQGIGaGGLMPGALALIAELF 131

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 767958514  95 QEHERSTAYGWVSATFAASLVSSPAIGAYLSASYG 129
Cdd:COG0477  132 PARERGRALGLWGAAIGLGLALGPLLGGLLVAALG 166
MFS_1 pfam07690
Major Facilitator Superfamily;
15-118 2.63e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 42.79  E-value: 2.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514   15 LMNGLIQGVKGLLSFLSAPLIGALSDVWGRKPFLLGTVF------FTCFPIPLMRISPWWYFAMISVSGVFSVTFSVIFA 88
Cdd:pfam07690 235 LLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLllilaaLGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNA 314

                          90       100       110
                  ....*....|....*....|....*....|
gi 767958514   89 YVADVTQEHERSTAYGWVSATFAASLVSSP 118
Cdd:pfam07690 315 LVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 192-404 3.25e-04

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 42.80  E-value: 3.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 192 ICITVFLSYLPEAGqYSSFFLYLRQVIGFGSVKIAAFIAMVGILSIVAQtAFLSILMRSLGNKNTVLLGLGFQMLQLAWY 271
Cdd:cd06174    1 LLLGFFLTGLARGL-ISPLLPALLQSFGLSASQLGLLFALFSLGYALLQ-PLAGLLADRFGRRPVLLLGLLLFALGALLF 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 272 GFGSQAWMMWAAGTVAAM-SSITFPAISALVSRNAESDQQGVAQGIITGIRGLCNGLGPALYGFIFYMFHVELTELgpkl 350
Cdd:cd06174   79 AFAPSFWLLLLGRFLLGLgSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAV---- 154

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767958514 351 nsnnvplqgavipgppFLFGACIVLMSFLVALFIPEYSKASGVQKHSNSSSGSL 404
Cdd:cd06174  155 ----------------FLIAAALALLAAILLLLVVPDPPESARAKNEEASSKSV 192
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 18-335 3.37e-04

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 42.64  E-value: 3.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  18 GLIQGVKGLLSFLSAPLIGALSDVWGRKPFLLGTVFFTCFPIPLMRISP--WWYFAMISVSGVFSVTFSVIFAYVADVTQ 95
Cdd:cd17391   39 GLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTnvWQLLILRLLQGVFSGYVPNATALIASQTP 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  96 EhERStayGWVSATFAASLVS----SPAIGAYLSASYGDSLVVLVATVVALldICFILVAVpeSLPEKMRPVSWGAQISW 171
Cdd:cd17391  119 K-EKS---GWALGTLSTGVVAgtliGPLLGGFLADLFGIRNVFFITGGLLF--LAFLLTLF--FVKEDFKPVEKKKMVST 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 172 KQAdpfasLKKVGKDSTVLLICITVFLSylpeagQYSSFF------LYLRQVIGFGSvKIAAFIAMV----GILSIVAqT 241
Cdd:cd17391  191 KEV-----WNSVPNPSLLISLFVTTFII------QLANQSiepiltLYIRQLMGDAS-NLAFISGLVfsatGVSSLLS-A 257

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 242 AFLSILMRSLGNKNTVLLGLGFQMLQLAWYGFGSQAW-MMWAAGTVAAMSSITFPAISALVSRNAESDQQGVAQGIITGI 320
Cdd:cd17391  258 PRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWqLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSF 337

                        330
                 ....*....|....*
gi 767958514 321 RGLCNGLGPALYGFI 335
Cdd:cd17391  338 QYLGNVAGPLLGSAI 352
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 18-344 5.03e-04

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 42.15  E-value: 5.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  18 GLIQGVKGLLSFLSAPLIGALSDVWG-RKPFLLGTVFFTCFPIPLMRISPWWYFAMISVS------GVFSvtfSVIFAYV 90
Cdd:cd17370   37 GLIEGLAEALGSLLRLFSGYLSDRTGkRKPLVILGYGLSALAKPLLALAGSWQLVLLLRIlerlgkGIRT---PPRDALL 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  91 ADVTQEHERSTAYGWVSA--TFAASLvsSPAIGAYLSASYGDSLVVLVATVVALLDI-CFILVAVPESLPEKMRPvswga 167
Cdd:cd17370  114 ADATPPSGRGKAFGLHRAldTLGAVL--GPLLAALLLYLLGGNYRTIFLLAAIPALLaLLILLFVVKEYPRPPKL----- 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 168 qiswKQADPFASLKKVGKDSTVLLICITVFlsylpEAGQYS-SFFLYLRQVIGFGSVKIAAFIAMVGILSIVAQTAFlSI 246
Cdd:cd17370  187 ----RKKSKKTSLKKLPKAFWLYLLAVALF-----ALGNFSfAFLILRAQELGLSAALIPLLYALFNLVYALAAYPA-GR 256

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 247 LMRSLGNKNTVLLGLGFQMLQLAWYGFGSQAWMMWAAGTVAAMS-SITFPAISALVSRNAESDQQGVAQGIITGIRGLCN 325
Cdd:cd17370  257 LSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYmGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGW 336

                        330
                 ....*....|....*....
gi 767958514 326 GLGPALYGFIFYMFHVELT 344
Cdd:cd17370  337 LLASLIAGYLWDLISPSAA 355
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
 30-336 6.74e-04

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 41.82  E-value: 6.74e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  30 LSAPLIGALSDV----WG-RKPFLL------GTVFFTCF--PIPLMRISPWWYFAMISVSGVFSVTFSVIF-AYVADVTQ 95
Cdd:cd17332   50 INDPLMGYLIDRtrsrWGrFRPWLLwgaiplALLFVLLFttPDGSGTGKLIYALITYILLDLLYTLVNIPYtALIPELTD 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  96 E-HERSTAYGW--VSATFAASLVSS--PAIGAYLSASYGDSLVVLVATVVALLDICFILVAVPESlpekmRPVSWGAQIS 170
Cdd:cd17332  130 DpEERTSLTSWrmFFATIGGLLVTVlpPPLVAYFGGGNASRGYFLTALIIGIIGIILLLICFFGT-----RERVVPPEEE 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 171 WKQADPFASLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQVIGfGSVKIAAFIAMVGILSIVAqTAFLSILMRS 250
Cdd:cd17332  205 KSKLPLLKSLKALLKNRPFLILLLAYLLYFLAFNIVNTVLVYYFKYVLG-GRAELVLLLLLILSGALLA-LLPWPPLKKR 282

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 251 LGNKNTVLLGLGFQMLQLAWYGFGS--QAWMMWAAGTVAAM-SSITFPAISALVSRNAESDQ--QGV-AQGIITGIRGLC 324
Cdd:cd17332  283 FGKKKAFFIGLLLAILGLLLLFFLPpgNLVLILVLAVLAGIgYGGANLLPWAMLADVIDYGElkTGKrREGIFYSVMTFF 362

                        330
                 ....*....|..
gi 767958514 325 NGLGPALYGFIF 336
Cdd:cd17332  363 RKLGLALAGALV 374
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 18-383 6.97e-04

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 41.84  E-value: 6.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  18 GLIQGVKGLLSFLSAPLIGALSDV----WG-RKPFLLGTVFFTCFPIPLMRISPWWYFAMISVSGVFSVTFSVIF----- 87
Cdd:cd17313   37 GFVWTLGPILGLFVQPLVGSLSDRcnsrIGrRRPFILVGAPLAALGLILIPNAADIGLALGDGPRTWALVLFVLGivlld 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  88 -----------AYVADVTQEHERSTAYGWVSatFAASLVSspaIGAYLSASYGDSLVVLVATVVALLDICFILVA----- 151
Cdd:cd17313  117 famnvcqgpvrALLPDLVPPEQRSKANGIIN--FMGGLGG---VLGYLLGAILWDHNWFGFALGGNLKVPFYIGAiillv 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 152 --------VPEslpEKMRPVSWGAQISWKQADPFASLKKV--GKDSTVLLICITVFLSYLpeAGQYSSFF--LYLRQVIG 219
Cdd:cd17313  192 cvlvtlffVKE---PPLSPEAGEHSENPSLGEVLKSLLKLlkIMPRSLLRLLLVIFFWWI--AFFPFELFftDYMGEEVY 266

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 220 FG----------SVKIAAFIAMVGILSIVAQTAFLSILMRSLGNKNTVLLGLGFQMLQLAWYGFGSQAW----MMWAAG- 284
Cdd:cd17313  267 HGtsaasshygaGVRMGAWGLLIFSLAFLIFSLPIGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTvalvLFALGGi 346

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 285 TVAAMSSITFPAISALVSRNAESdqQGVAQGIITGIRGLCNGLGPALYGFIFYMFHVeltelgpklnsnnvplqgavipG 364
Cdd:cd17313  347 GWATININPYPLVSDYHSESGRG--QGTDTGLLNLAISLAQILVSLLAGPIIDVKGY----------------------G 402

                        410
                 ....*....|....*....
gi 767958514 365 PPFLFGACIVLMSFLVALF 383
Cdd:cd17313  403 TVFPVAAVASFLSLVGALF 421
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
188-335 7.23e-04

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 41.50  E-value: 7.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 188 TVLLICITVFLSYLpEAGQYSSFFLYLRQVIGFGSVKIAAFIAMVGILSIVAQtAFLSILMRSLGNKNTVLLGLGFQMLQ 267
Cdd:COG2814   11 ALLALALGAFLSGL-GIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGA-PLAGRLADRFGRRRVLLLGLLLFALG 88

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767958514 268 LAWYGFGSQAWMMWAAGTVAAM-SSITFPAISALVSRNAESDQQGVAQGIITGIRGLCNGLGPALYGFI 335
Cdd:COG2814   89 SLLCALAPSLWLLLAARFLQGLgAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLL 157
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 192-386 1.09e-03

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 41.02  E-value: 1.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 192 ICITVFLSYLPEAGQYSSFFLYLRQvIGFGSVKIAAFIAMVGILSIVAQTaFLSILMRSLGNKNTVLLGLGFQMLQLAWY 271
Cdd:cd17325    1 LSLALFLDMLGYGIIIPILPLYAES-LGASVAQIGLIVAAYALAQLLFSP-PAGRLSDRFGRKRLLLLGLLLLAVSTLLF 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 272 GFGSQAWMMWAAGTVA-AMSSITFPAISALVSRNAESDQQGVAQGIITGIRGLCNGLGPALYGFIFYMFHVELtelgpkl 350
Cdd:cd17325   79 AFATSYWQLLLARFLQgLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRA------- 151

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 767958514 351 nsnnvplqgavipgpPFLFGACIVLMSFLVALFIPE 386
Cdd:cd17325  152 ---------------PFLVCAALALLALVLALLLLP 172
MFS_KgtP cd17367
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ...
 25-104 2.49e-03

Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340925 [Multi-domain]  Cd Length: 407  Bit Score: 39.97  E-value: 2.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  25 GLLSFLSAPLIGALSDVWGRKPFLLGT-VFFTCFPIPLMRI-----SPWWYFAMISVSGVFSVTFSVIFAYV-ADVTQEH 97
Cdd:cd17367  269 LLVFMLLQPLGGRLSDRIGRRPLLLFFgIGGTLATVPLLSAldhtdSPYTAFALVLVGLVFLSGYTSINAVVkAELFPTH 348


                 ....*..
gi 767958514  98 ERSTAYG 104
Cdd:cd17367  349 VRALGVG 355
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 25-129 2.57e-03

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 39.89  E-value: 2.57e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  25 GLLSFLSAPLIGALSDVWGRKPFLL-GTVFFTCFPIPL---MRISPWWYFAMISVSGVFSVTFSVIF-AYVADVTQEHER 99
Cdd:cd17316  223 SLGALVGALIAGLLSDRIGRKKTLViGLILSGILALPLfylLSGSPTLLLLLLFILSFFVGGVWGALyAYLAELFPTEVR 302

                         90       100       110
                 ....*....|....*....|....*....|.
gi 767958514 100 STAYGWVSAT-FAASLVSSPAIGAYLSASYG 129
Cdd:cd17316  303 ATGVGLSYNLgRLGGGGAPPLIALLLASTGG 333
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 26-129 2.63e-03

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 39.87  E-value: 2.63e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  26 LLSFLSAPLIGA-LSDVWGRKP-FLLGTVFFTCFPIPL-MRISPWWYFAMISVSGVFSVTFSVIFA-YVADVTQEHERST 101
Cdd:cd17323   44 VLGFGLGPLIWApLSELYGRRPvYLVSLFIFVIFQIGCaLAPNIAMLIILRFLQGFFGSSPLAIGAgTIADLFTPEERGK 123

                         90       100
                 ....*....|....*....|....*....
gi 767958514 102 AYG-WVSATFAASLVsSPAIGAYLSASYG 129
Cdd:cd17323  124 AMGvYSLGPLLGPAL-GPIIGGFITQSLG 151
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 185-385 3.93e-03

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 39.10  E-value: 3.93e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 185 KDSTVLLICITVFLSYLpeaGQYSSFF---LYLRQVIGFGSVKIAAFIAMVGILSIVAQTaFLSILMRSLGNKNTVLLGL 261
Cdd:cd17503  176 KDRNFTLGLLLSFLLGL---GLFGAMFllpLYLQNVLGYSAFESGLVLAPGGLASAILSP-LVGRLLDKFGPRLLLLAGL 251

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 262 ---GFQMLQLAWYGFGSQAWMMWAAGTVAAMS-SITFPAISALVSRNAESDQQGVAQGIITGIRGLCNGLGPALYGFIFY 337
Cdd:cd17503  252 lllALGTLLLAFLTPDTSLWLIILPLFIRGLGmGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATLLT 331

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 767958514 338 MFHVELTELGPKLNSNNVPLQGAVIP-GPPFLFGACIVLMSFLVALFIP 385
Cdd:cd17503  332 NRTQFHHSRLSELLAQQVQKQALIIAfNDAFLVSAILLLVGLLLALFLR 380
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 1-344 4.21e-03

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 39.08  E-value: 4.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514   1 MLTVLHETFSqHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKPFLLGTVFFTCFPIPLMRISP--WWYFAMISVSGV 78
Cdd:cd17478   18 LLPLLIAKLG-LSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPnyWLLLLLVALAGI 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  79 FSVTFSVIFAYVADVTQEHERSTAYGWVSA--TFAASLvsSPAIGAYLSASYGDSLVVLVATVVAlldICFILVAVPESL 156
Cdd:cd17478   97 GSAAFHPEGARLASQAAGGRRGLAMSIFSVggNLGFAL--GPLIAAALVALFGGLGLLILLIIPG---LAVALLLLRLRP 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 157 PEKMRPVSWGAQISWKQAdpfaslkKVGKDSTVLLICITVFLSYLPEAGqYSSFF-LYLRQVigFGSVKIAAFIAMVGIL 235
Cdd:cd17478  172 LKKPEAKKAAAKSSARST-------LKGVWRALLLLLIIVFLRSWVLSS-LTTFLpFYLVQR--GYSLVFAGLLLSLFLF 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514 236 SIVAQTAFLSILMRSLGNKNTVLLGLGFQMLQLAWYGFGSQAWMMWAAGTVAAMSSITFPAISALVSRNAeSDQQGVAQG 315
Cdd:cd17478  242 AGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLAQELL-PGNVGLASG 320

                        330       340
                 ....*....|....*....|....*....
gi 767958514 316 IITGIRGLCNGLGPALYGFIFYMFHVELT 344
Cdd:cd17478  321 LMMGLSFGLGGIGAPVLGALADAFGLESV 349
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 26-129 4.70e-03

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 39.08  E-value: 4.70e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  26 LLSFLSAPLIGALSDVWGRKP-FLLGTVFFT--CFPIPLMRISPWWYFAM----ISVSGVFSVTFSVIfayvADVTQEHE 98
Cdd:cd17502   41 LTSTAFQPIYGKLSDLFGRKWvLLIAIVIFElgSLLCGLAPNMTMLIVGRaiqgIGGGGLMSLAFIII----ADLVPPRE 116

                         90       100       110
                 ....*....|....*....|....*....|.
gi 767958514  99 RSTAYGWVSATFAASLVSSPAIGAYLSASYG 129
Cdd:cd17502  117 RGKYQGYIGAVFGIASVAGPLIGGAFTDHLS 147
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 22-129 5.19e-03

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 38.75  E-value: 5.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  22 GVKGLLSFLSAPLIGALSDVWGRKP---FLLGTVFFTCFPIPLMRISPWWYFAMISVSGV-FSVTFSVIFAYVADVTQEH 97
Cdd:cd17353  256 SILSIFNGGGRPFWGWLSDKIGRKNtlsIAFLIQGVAMFLLPFIGSVAVLFVLGVALIGFcYGGGFALFPALTADFFGTK 335

                         90       100       110
                 ....*....|....*....|....*....|..
gi 767958514  98 ERSTAYGWVSATFAASLVSSPAIGAYLSASYG 129
Cdd:cd17353  336 NAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGG 367
MFS_2 pfam13347
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ...
 15-336 7.73e-03

MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.


Pssm-ID: 433134 [Multi-domain]  Cd Length: 427  Bit Score: 38.44  E-value: 7.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514   15 LMNGLIQGVKGLLSFLSAPLIGALSDVWGRKPFLLGTVFFTCFPIPlmrispwwYFAMISVSGVFSvtfsvifayvadvt 94
Cdd:pfam13347  72 LLSAIILAVSFILLFTPPELGRAPLFIWLLATYILLRIAYTFFEIP--------YWSLGPELTRDY-------------- 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514   95 qeHERSTAYGWVS-----ATFAASLVSSPAIGAYLS-ASYGDSLVVLVATVVALLDICFILVAVPESLPEKMRPVSWGAQ 168
Cdd:pfam13347 130 --DERTSLTSYRSffsvgGGLLAAALAFPLVLILGGtGLERKGYRIFALIGAVLMLLGVIITAAGTKERVSMRSKEDTGQ 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  169 ISWKQAdpFASLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQVIGFGSVkiAAFIAMVGILSIVAQTAFLSILM 248
Cdd:pfam13347 208 KEAGSL--LDMLKEVFRNRAFLILLASFLLAALAMGVLNGLLLYYFRYVLGNGFA--ASAFPLVFTIGALLGIPLWPPLA 283

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958514  249 RSLGNKNTVLLGLGFQM--LQLAWYGFGSQAWMMWAAGTVA----AMSSITFPAISALVSRNAESDQQGVAQGIITGIRG 322
Cdd:pfam13347 284 KRIGKKNTYILGALITIagFALALLLGPNNTLLFLVLYIIIgfgyGSSFFLPWSMLADVVDYGELRTGKRREGTFFAMWS 363

                         330
                  ....*....|....
gi 767958514  323 LCNGLGPALYGFIF 336
Cdd:pfam13347 364 FISKLATGVGLGVS 377
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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