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Conserved domains on  [gi|767960566|ref|XP_011517991|]
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enoyl-CoA hydratase domain-containing protein 3, mitochondrial isoform X2 [Homo sapiens]

Protein Classification

Clp protease/crotonase-like domain-containing protein( domain architecture ID 581041)

Clp protease/crotonase-like domain-containing protein similar to Oryza sativa enoyl-CoA delta isomerase which plays a role in fatty acid metabolism, which involves stabilization of an enolate anion intermediate derived from an acyl-CoA substrate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
crotonase-like super family cl23717
Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse ...
 54-234 1.07e-54

Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.


The actual alignment was detected with superfamily member PRK08139:

Pssm-ID: 474030  Cd Length: 266  Bit Score: 176.29  E-value: 1.07e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566  54 DGIRNIVLSNPKKRNALSLAMLKSLQSDILHDADSNDLKVIIISAEGPVFSSGHDLKELTEEQGRDYHAEVFQTCS---- 129
Cdd:PRK08139  19 DGVATLTLNRPQAFNALSEAMLAALQAALDAIAADPSVRVVVLAAAGKAFCAGHDLKEMRAARGLAYFRALFARCSrvmq 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 130 ---------------------------------------------------------------KVALEMLFTGEPISAQE 146
Cdd:PRK08139  99 aivalpqpviarvhgiataagcqlvascdlavaadtarfavpgvniglfcstpmvalsrnvprKQAMEMLLTGEFIDAAT 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 147 ALLHGLLSKVVPEAELQEETMRIARKIASLSRPVVSLGKATFYKQLPQDLGTAYYLTSQAMVDNLALRDGQEGITAFLQK 226
Cdd:PRK08139 179 AREWGLVNRVVPADALDAAVARLAAVIAAKSPAAVRIGKEAFYRQAEMPLADAYAYAGDVMAENMMAEDAEEGIDAFLEK 258


                 ....*...
gi 767960566 227 RKPVWSHE 234
Cdd:PRK08139 259 RPPEWRGR 266
 
Name Accession Description Interval E-value
PRK08139 PRK08139
enoyl-CoA hydratase; Validated
 54-234 1.07e-54

enoyl-CoA hydratase; Validated


Pssm-ID: 181249  Cd Length: 266  Bit Score: 176.29  E-value: 1.07e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566  54 DGIRNIVLSNPKKRNALSLAMLKSLQSDILHDADSNDLKVIIISAEGPVFSSGHDLKELTEEQGRDYHAEVFQTCS---- 129
Cdd:PRK08139  19 DGVATLTLNRPQAFNALSEAMLAALQAALDAIAADPSVRVVVLAAAGKAFCAGHDLKEMRAARGLAYFRALFARCSrvmq 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 130 ---------------------------------------------------------------KVALEMLFTGEPISAQE 146
Cdd:PRK08139  99 aivalpqpviarvhgiataagcqlvascdlavaadtarfavpgvniglfcstpmvalsrnvprKQAMEMLLTGEFIDAAT 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 147 ALLHGLLSKVVPEAELQEETMRIARKIASLSRPVVSLGKATFYKQLPQDLGTAYYLTSQAMVDNLALRDGQEGITAFLQK 226
Cdd:PRK08139 179 AREWGLVNRVVPADALDAAVARLAAVIAAKSPAAVRIGKEAFYRQAEMPLADAYAYAGDVMAENMMAEDAEEGIDAFLEK 258


                 ....*...
gi 767960566 227 RKPVWSHE 234
Cdd:PRK08139 259 RPPEWRGR 266
CaiD COG1024
Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase ...
 54-228 3.65e-38

Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase/carnithine racemase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440647 [Multi-domain]  Cd Length: 249  Bit Score: 132.98  E-value: 3.65e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566  54 DGIRNIVLSNPKKRNALSLAMLKSLQsDILHDADSND-LKVIIISAEGPVFSSGHDLKELTEEQGRDYHAEVF------- 125
Cdd:COG1024    7 GGVATITLNRPEKLNALSLEMLAELA-AALDEAEADPdVRVVVLTGAGKAFCAGADLKELAAAADPEEARAFArglqrlf 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 126 ---QTCSK----------------------------------------------------------VALEMLFTGEPISA 144
Cdd:COG1024   86 ralRRLPKpviaavngaalggglelalacdlriaaedarfglpevrlglipggggtqrlprlvglaRAKELLLTGRRIDA 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 145 QEALLHGLLSKVVPEAELQEETMRIARKIASLSRPVVSLGKATFYKQLPQDLGTAYYLTSQAMVDNLALRDGQEGITAFL 224
Cdd:COG1024  166 EEALELGLVNRVVPDDELLAAALALAARLAAGPPLALAATKRALNAALEAPLDEALELEAEAFAELFASEDAREGIAAFL 245


                 ....
gi 767960566 225 QKRK 228
Cdd:COG1024  246 EKRK 249
crotonase-like cd06558
Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse ...
 54-173 5.70e-25

Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.


Pssm-ID: 119339 [Multi-domain]  Cd Length: 195  Bit Score: 97.25  E-value: 5.70e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566  54 DGIRNIVLSNPKKRNALSLAMLKSLQsDILHDADSND-LKVIIISAEGPVFSSGHDLKELTEEQGRDYHAEVF------- 125
Cdd:cd06558    7 GGVATITLNRPEKRNALSLEMLDELA-AALDEAEADPdVRVVVLTGAGKAFCAGADLKELAALSDAGEEARAFirelqel 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 126 ----QTCSKV----------------------------------------------------------ALEMLFTGEPIS 143
Cdd:cd06558   86 lralLRLPKPviaavngaalggglelalacdiriaaedakfglpevklglvpggggtqrlprlvgparARELLLTGRRIS 165

                        170       180       190
                 ....*....|....*....|....*....|
gi 767960566 144 AQEALLHGLLSKVVPEAELQEETMRIARKI 173
Cdd:cd06558  166 AEEALELGLVDEVVPDEELLAAALELARRL 195
ECH_1 pfam00378
Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: ...
 55-231 6.19e-23

Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: enoyl-CoA hydratase, napthoate synthase, carnitate racemase, 3-hydroxybutyryl-CoA dehydratase and dodecanoyl-CoA delta-isomerase.


Pssm-ID: 395302 [Multi-domain]  Cd Length: 251  Bit Score: 93.19  E-value: 6.19e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566   55 GIRNIVLSNPKKRNALSLAMLKSLqSDILHDADSN-DLKVIIISAEGPVFSSGHDLKELTEEQGRDY---------HAEV 124
Cdd:pfam00378   5 GVAVITLNRPEAVNALSAELITEL-IQALEKLRTDpSVRAVVLTGGDKAFCAGADLKEMYGEGPAHQalyrenvldLWTL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566  125 FQTCSKV----------------------------------------------------------ALEMLFTGEPISAQE 146
Cdd:pfam00378  84 LYTCPKPviaavngyaigggcelalacdiiiaadnasfglnetklgiipgaggtdrlpriighskAMEMLLLGRRISAQE 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566  147 ALLHGLLSKVVPEAELQEETMRIARKIASLSRPVVSLGKATFYKQLPQDLGTAYYLTSQAMVDNLALRDGQEGITAFLQK 226
Cdd:pfam00378 164 ALKWGLVDKVVPEDQLLDEARELAEKLAEKSPAALAQLKKALNAKLEDALPTQLEAEARLFYSTFSKDDIIEGLQAFLEK 243


                  ....*
gi 767960566  227 RKPVW 231
Cdd:pfam00378 244 RKPPW 248
 
Name Accession Description Interval E-value
PRK08139 PRK08139
enoyl-CoA hydratase; Validated
 54-234 1.07e-54

enoyl-CoA hydratase; Validated


Pssm-ID: 181249  Cd Length: 266  Bit Score: 176.29  E-value: 1.07e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566  54 DGIRNIVLSNPKKRNALSLAMLKSLQSDILHDADSNDLKVIIISAEGPVFSSGHDLKELTEEQGRDYHAEVFQTCS---- 129
Cdd:PRK08139  19 DGVATLTLNRPQAFNALSEAMLAALQAALDAIAADPSVRVVVLAAAGKAFCAGHDLKEMRAARGLAYFRALFARCSrvmq 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 130 ---------------------------------------------------------------KVALEMLFTGEPISAQE 146
Cdd:PRK08139  99 aivalpqpviarvhgiataagcqlvascdlavaadtarfavpgvniglfcstpmvalsrnvprKQAMEMLLTGEFIDAAT 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 147 ALLHGLLSKVVPEAELQEETMRIARKIASLSRPVVSLGKATFYKQLPQDLGTAYYLTSQAMVDNLALRDGQEGITAFLQK 226
Cdd:PRK08139 179 AREWGLVNRVVPADALDAAVARLAAVIAAKSPAAVRIGKEAFYRQAEMPLADAYAYAGDVMAENMMAEDAEEGIDAFLEK 258


                 ....*...
gi 767960566 227 RKPVWSHE 234
Cdd:PRK08139 259 RPPEWRGR 266
CaiD COG1024
Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase ...
 54-228 3.65e-38

Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase/carnithine racemase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440647 [Multi-domain]  Cd Length: 249  Bit Score: 132.98  E-value: 3.65e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566  54 DGIRNIVLSNPKKRNALSLAMLKSLQsDILHDADSND-LKVIIISAEGPVFSSGHDLKELTEEQGRDYHAEVF------- 125
Cdd:COG1024    7 GGVATITLNRPEKLNALSLEMLAELA-AALDEAEADPdVRVVVLTGAGKAFCAGADLKELAAAADPEEARAFArglqrlf 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 126 ---QTCSK----------------------------------------------------------VALEMLFTGEPISA 144
Cdd:COG1024   86 ralRRLPKpviaavngaalggglelalacdlriaaedarfglpevrlglipggggtqrlprlvglaRAKELLLTGRRIDA 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 145 QEALLHGLLSKVVPEAELQEETMRIARKIASLSRPVVSLGKATFYKQLPQDLGTAYYLTSQAMVDNLALRDGQEGITAFL 224
Cdd:COG1024  166 EEALELGLVNRVVPDDELLAAALALAARLAAGPPLALAATKRALNAALEAPLDEALELEAEAFAELFASEDAREGIAAFL 245


                 ....
gi 767960566 225 QKRK 228
Cdd:COG1024  246 EKRK 249
PRK11423 PRK11423
methylmalonyl-CoA decarboxylase; Provisional
 54-234 2.11e-27

methylmalonyl-CoA decarboxylase; Provisional


Pssm-ID: 236908 [Multi-domain]  Cd Length: 261  Bit Score: 105.49  E-value: 2.11e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566  54 DGIRNIVLSNPKKRNALSLAMLKSLQSDiLHDADSNDLKVIIISAE--GPVFSSGHDLKELTEEqGRD------------ 119
Cdd:PRK11423  12 NKIATITFNNPAKRNALSKVLIDDLMQA-LSDLNRPEIRVVILRAPsgSKVWSAGHDIHELPSG-GRDplsyddplrqil 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 120 -----YHAEVF------------------------QTCS--------------------------KVALEMLFTGEPISA 144
Cdd:PRK11423  90 rmiqkFPKPVIamvegsvwggafelimscdliiaaSTSTfamtpanlgvpynlsgilnftndagfHIVKEMFFTASPITA 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 145 QEALLHGLLSKVVPEAELQEETMRIARKIASLSRPVVSLGKatfyKQLpQDLGTAYYLTSQAMVDNLALR-------DGQ 217
Cdd:PRK11423 170 QRALAVGILNHVVEVEELEDFTLQMAHHISEKAPLAIAVIK----EQL-RVLGEAHPMNPDEFERIQGLRravydseDYQ 244

                        250
                 ....*....|....*..
gi 767960566 218 EGITAFLQKRKPVWSHE 234
Cdd:PRK11423 245 EGMNAFLEKRKPVFVGH 261
PRK07658 PRK07658
enoyl-CoA hydratase; Provisional
 54-232 1.72e-25

enoyl-CoA hydratase; Provisional


Pssm-ID: 181070 [Multi-domain]  Cd Length: 257  Bit Score: 100.09  E-value: 1.72e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566  54 DGIRNIVLSNPKKrNALSLAMLKSLqSDILHDADSND-LKVIIISAEGPVFSSGHDLKELTE-EQGRDYHA--------- 122
Cdd:PRK07658  10 DHVAVITLNHPPA-NALSSQVLHEL-SELLDQVEKDDnVRVVVIHGEGRFFSAGADIKEFTSvTEAEQATElaqlgqvtf 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 123 EVFQTCSK----------------------------------------------------------VALEMLFTGEPISA 144
Cdd:PRK07658  88 ERVEKFSKpviaaihgaalggglelamschirfatesaklglpelnlglipgfagtqrlpryvgkaKALEMMLTSEPITG 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 145 QEALLHGLLSKVVPEAELQEETMRIARKIASLS----RPVVSLGKATFYKQLPQDLGTAYYLTSQAMVDNlalrDGQEGI 220
Cdd:PRK07658 168 AEALKWGLVNGVFPEETLLDDAKKLAKKIAGKSpattRAVLELLQTTKSSSYYEGVKREAKIFGEVFTSE----DAKEGV 243

                        250
                 ....*....|..
gi 767960566 221 TAFLQKRKPVWS 232
Cdd:PRK07658 244 QAFLEKRKPSFS 255
crotonase-like cd06558
Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse ...
 54-173 5.70e-25

Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.


Pssm-ID: 119339 [Multi-domain]  Cd Length: 195  Bit Score: 97.25  E-value: 5.70e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566  54 DGIRNIVLSNPKKRNALSLAMLKSLQsDILHDADSND-LKVIIISAEGPVFSSGHDLKELTEEQGRDYHAEVF------- 125
Cdd:cd06558    7 GGVATITLNRPEKRNALSLEMLDELA-AALDEAEADPdVRVVVLTGAGKAFCAGADLKELAALSDAGEEARAFirelqel 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 126 ----QTCSKV----------------------------------------------------------ALEMLFTGEPIS 143
Cdd:cd06558   86 lralLRLPKPviaavngaalggglelalacdiriaaedakfglpevklglvpggggtqrlprlvgparARELLLTGRRIS 165

                        170       180       190
                 ....*....|....*....|....*....|
gi 767960566 144 AQEALLHGLLSKVVPEAELQEETMRIARKI 173
Cdd:cd06558  166 AEEALELGLVDEVVPDEELLAAALELARRL 195
ECH_1 pfam00378
Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: ...
 55-231 6.19e-23

Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: enoyl-CoA hydratase, napthoate synthase, carnitate racemase, 3-hydroxybutyryl-CoA dehydratase and dodecanoyl-CoA delta-isomerase.


Pssm-ID: 395302 [Multi-domain]  Cd Length: 251  Bit Score: 93.19  E-value: 6.19e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566   55 GIRNIVLSNPKKRNALSLAMLKSLqSDILHDADSN-DLKVIIISAEGPVFSSGHDLKELTEEQGRDY---------HAEV 124
Cdd:pfam00378   5 GVAVITLNRPEAVNALSAELITEL-IQALEKLRTDpSVRAVVLTGGDKAFCAGADLKEMYGEGPAHQalyrenvldLWTL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566  125 FQTCSKV----------------------------------------------------------ALEMLFTGEPISAQE 146
Cdd:pfam00378  84 LYTCPKPviaavngyaigggcelalacdiiiaadnasfglnetklgiipgaggtdrlpriighskAMEMLLLGRRISAQE 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566  147 ALLHGLLSKVVPEAELQEETMRIARKIASLSRPVVSLGKATFYKQLPQDLGTAYYLTSQAMVDNLALRDGQEGITAFLQK 226
Cdd:pfam00378 164 ALKWGLVDKVVPEDQLLDEARELAEKLAEKSPAALAQLKKALNAKLEDALPTQLEAEARLFYSTFSKDDIIEGLQAFLEK 243


                  ....*
gi 767960566  227 RKPVW 231
Cdd:pfam00378 244 RKPPW 248
PRK06688 PRK06688
enoyl-CoA hydratase; Provisional
 54-233 7.43e-22

enoyl-CoA hydratase; Provisional


Pssm-ID: 235852 [Multi-domain]  Cd Length: 259  Bit Score: 90.70  E-value: 7.43e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566  54 DGIRNIVLSNPKKRNALSLAMLKSLqSDILHDA-DSNDLKVIIISAEGPVFSSGHDLKELTEE--QGRDYHAEVFQ---- 126
Cdd:PRK06688  13 DGVLTITINRPDKKNALTAAMYQAL-ADALEAAaTDPAVRVVVLTGAGRAFSAGGDIKDFPKAppKPPDELAPVNRflra 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 127 -------------------------TC---------------SKVAL--------------------EMLFTGEPISAQE 146
Cdd:PRK06688  92 iaalpkpvvaavngpavgvgvslalACdlvyasesakfslpfAKLGLcpdaggsallprligraraaEMLLLGEPLSAEE 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 147 ALLHGLLSKVVPEAELQEETMRIARKIASLSRPVVSLGKATFYKQLPQDLGTAYYLTSQAMVDNLALRDGQEGITAFLQK 226
Cdd:PRK06688 172 ALRIGLVNRVVPAAELDAEADAQAAKLAAGPASALRYTKRAINAATLTELEEALAREAAGFGRLLRTPDFREGATAFIEK 251


                 ....*..
gi 767960566 227 RKPVWSH 233
Cdd:PRK06688 252 RKPDFTG 258
PRK07657 PRK07657
enoyl-CoA hydratase; Provisional
 55-234 1.13e-20

enoyl-CoA hydratase; Provisional


Pssm-ID: 181069 [Multi-domain]  Cd Length: 260  Bit Score: 87.48  E-value: 1.13e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566  55 GIRNIVLSNPKKRNALSLAMLKSLQSDILHDADSNDLKVIIISAEG-PVFSSGHDLKE---LTEEQGRDYHAEVFQTCSK 130
Cdd:PRK07657  13 HVVKITLNRPRAANALSLALLEELQNILTQINEEANVRVVILTGAGeKAFCAGADLKEragMNEEQVRHAVSLIRTTMEM 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 131 V----------------------------------------------------------------ALEMLFTGEPISAQE 146
Cdd:PRK07657  93 VeqlpqpviaaingialggglelalacdfriaaesaslgltettlaiipgaggtqrlprligvgrAKELIYTGRRISAQE 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 147 ALLHGLLSKVVPEAELQEETMRIARKIASLSRPVVSLGKATFYKQLPQDLGTAYYLTSQAMVDNLALRDGQEGITAFLQK 226
Cdd:PRK07657 173 AKEIGLVEFVVPAHLLEEKAIEIAEKIASNGPIAVRQAKEAISNGIQVDLHTGLQIEKQAYEGTIPTKDRLEGLQAFKEK 252


                 ....*...
gi 767960566 227 RKPVWSHE 234
Cdd:PRK07657 253 RKPMYKGE 260
PRK08290 PRK08290
enoyl-CoA hydratase; Provisional
 54-178 6.27e-20

enoyl-CoA hydratase; Provisional


Pssm-ID: 236220 [Multi-domain]  Cd Length: 288  Bit Score: 85.78  E-value: 6.27e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566  54 DGIRNIVLSNPKKRNALSLAMLKSLqSDILHDADSND-LKVIIISAEGPVFSSGHDLKELTEE----------------- 115
Cdd:PRK08290  12 GRIARITLNRPEARNAQNRQMLYEL-DAAFRRAEADDaVRVIVLAGAGKHFSAGHDLGSGTPGrdrdpgpdqhptlwwdg 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 116 -----------------------------------QGR-----------------------------------DYHAEVF 125
Cdd:PRK08290  91 atkpgveqryarewevylgmcrrwrdlpkptiaqvQGAciagglmlawvcdlivasddaffsdpvvrmgipgvEYFAHPW 170

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 767960566 126 QTCSKVALEMLFTGEPISAQEALLHGLLSKVVPEAELQEETMRIARKIASLSR 178
Cdd:PRK08290 171 ELGPRKAKELLFTGDRLTADEAHRLGMVNRVVPRDELEAETLELARRIAAMPP 223
PRK05809 PRK05809
short-chain-enoyl-CoA hydratase;
54-229 3.22e-17

short-chain-enoyl-CoA hydratase;


Pssm-ID: 180270 [Multi-domain]  Cd Length: 260  Bit Score: 78.25  E-value: 3.22e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566  54 DGIRNIVLSNPKKRNALSLAMLKSLQSDILHDADSNDLKVIIISAEGP-VFSSGHD---LKELTEEQGRDYHA---EVF- 125
Cdd:PRK05809  12 GHIAVVTINRPKALNALNSETLKELDTVLDDIENDDNVYAVILTGAGEkAFVAGADiseMKDLNEEEGRKFGLlgnKVFr 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 126 --QTCSK----------------------------------------------------------VALEMLFTGEPISAQ 145
Cdd:PRK05809  92 klENLDKpviaaingfalgggcelsmacdiriasekakfgqpevglgitpgfggtqrlarivgpgKAKELIYTGDMINAE 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 146 EALLHGLLSKVVPEAELQEETMRIARKIASLSRPVVSLGKATFYKQLPQDLGTAYYLTSQAMVDNLALRDGQEGITAFLQ 225
Cdd:PRK05809 172 EALRIGLVNKVVEPEKLMEEAKALANKIAANAPIAVKLCKDAINRGMQVDIDTAVAIEAEDFGECFSTEDQTEGMTAFVE 251


                 ....
gi 767960566 226 KRKP 229
Cdd:PRK05809 252 KREK 255
PRK09674 PRK09674
enoyl-CoA hydratase-isomerase; Provisional
 52-229 8.59e-17

enoyl-CoA hydratase-isomerase; Provisional


Pssm-ID: 182026 [Multi-domain]  Cd Length: 255  Bit Score: 76.73  E-value: 8.59e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566  52 QLDGIRNIVLSNPKKRNALSLAMLKSLQSDILHDADSNDLKVIIISAEGPVFSSGHDLKELTEeqgRDYHA--------- 122
Cdd:PRK09674   8 RQQRVLLLTLNRPEARNALNNALLTQLVNELEAAATDTSIGVCVITGNARFFAAGADLNEMAE---KDLAAtlndprpql 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 123 ------------------------EVFQTCSKV-----------------------------------ALEMLFTGEPIS 143
Cdd:PRK09674  85 wqrlqafnkpliaavngyalgagcELALLCDIViagenarfglpeitlgimpgaggtqrlirsvgkslASQMVLTGESIT 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 144 AQEALLHGLLSKVVPEAELQEETMRIARKIASLSRPVVSLGKATFYKQLPQDLGTAYYLTSQAMVDNLALRDGQEGITAF 223
Cdd:PRK09674 165 AQQAQQAGLVSEVFPPELTLERALQLASKIARHSPLALRAAKQALRQSQEVDLQAGLAQERQLFTLLAATEDRHEGISAF 244


                 ....*.
gi 767960566 224 LQKRKP 229
Cdd:PRK09674 245 LEKRTP 250
PRK08138 PRK08138
enoyl-CoA hydratase; Provisional
 51-232 1.01e-15

enoyl-CoA hydratase; Provisional


Pssm-ID: 236162 [Multi-domain]  Cd Length: 261  Bit Score: 73.93  E-value: 1.01e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566  51 RQLDGIRNIVLSNPKKRNALSLAMLKSLQSDILHDADSNDLKVIIISAEGPVFSSGHDLKELTE-------EQGRDYHAE 123
Cdd:PRK08138  13 RPADGVALLRLNRPEARNALNMEVRQQLAEHFTELSEDPDIRAIVLTGGEKVFAAGADIKEFATagaiemyLRHTERYWE 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 124 VFQTCSK----------------------------------------------------------VALEMLFTGEPISAQ 145
Cdd:PRK08138  93 AIAQCPKpviaavngyalgggcelamhadiivagesasfgqpeikvglmpgaggtqrlvravgkfKAMRMALTGCMVPAP 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 146 EALLHGLLSKVVPEAELQEETMRIARKIASLS-------RPVVSLGkatfyKQLPqdLGTAYYLTSQAMVDNLALRDGQE 218
Cdd:PRK08138 173 EALAIGLVSEVVEDEQTLPRALELAREIARMPplalaqiKEVVLAG-----ADAP--LDAALALERKAFQLLFDSEDQKE 245

                        250
                 ....*....|....
gi 767960566 219 GITAFLQKRKPVWS 232
Cdd:PRK08138 246 GMDAFLEKRKPAYK 259
PRK06144 PRK06144
enoyl-CoA hydratase; Provisional
 39-232 2.23e-14

enoyl-CoA hydratase; Provisional


Pssm-ID: 180424 [Multi-domain]  Cd Length: 262  Bit Score: 70.41  E-value: 2.23e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566  39 GRRESEPRPTSARQlDGIRNIVLSNPKKRNALSLAM---LKSLQSDILHDADsndLKVIIIS-AEGPVFSSGHDLKELTE 114
Cdd:PRK06144   2 AMTTSTDELLLEVR-GGIARITFNRPAARNAMTWAMyegLAEICEAIAADPS---IRAVVLRgAGDKAFVAGTDIAQFRA 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 115 ----EQGRDYHAEV------FQTCSK----------------------------------------------------VA 132
Cdd:PRK06144  78 fstaEDAVAYERRIdrvlgaLEQLRVptiaaiagacvgggaaiaaacdlriatpsarfgfpiartlgnclsmsnlarlVA 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 133 L-------EMLFTGEPISAQEALLHGLLSKVVPEAELQEETMRIARKIASLSRPVVSLGKATFYKQLPQDLgtayyltsq 205
Cdd:PRK06144 158 LlgaarvkDMLFTARLLEAEEALAAGLVNEVVEDAALDARADALAELLAAHAPLTLRATKEALRRLRREGL--------- 228

                        250       260       270
                 ....*....|....*....|....*....|..
gi 767960566 206 AMVDNLALR-----DGQEGITAFLQKRKPVWS 232
Cdd:PRK06144 229 PDGDDLIRMcymseDFREGVEAFLEKRPPKWK 260
PRK09245 PRK09245
crotonase/enoyl-CoA hydratase family protein;
132-232 5.09e-14

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 181723  Cd Length: 266  Bit Score: 69.23  E-value: 5.09e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 132 ALEMLFTGEPISAQEALLHGLLSKVVPEAELQEETMRIARKIASLSRPVVSLGKATFYKQLPQDLGTAYYLTS--QAMVD 209
Cdd:PRK09245 164 AAEMAFTGDAIDAATALEWGLVSRVVPADQLLPAARALAERIAANPPHALRLTKRLLREGQHASLDTLLELSAayQALAH 243

                         90       100
                 ....*....|....*....|...
gi 767960566 210 NLAlrDGQEGITAFLQKRKPVWS 232
Cdd:PRK09245 244 HTA--DHREAVDAFLEKRPPVFT 264
PRK05862 PRK05862
enoyl-CoA hydratase; Provisional
 132-233 1.98e-13

enoyl-CoA hydratase; Provisional


Pssm-ID: 180295 [Multi-domain]  Cd Length: 257  Bit Score: 67.37  E-value: 1.98e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 132 ALEMLFTGEPISAQEALLHGLLSKVVPEAELQEETMRIARKIASLSRPVVSLGKATFYKQLPQDLGTAYYLTSQAMVDNL 211
Cdd:PRK05862 155 AMDLCLTGRMMDAAEAERAGLVSRVVPADKLLDEALAAATTIASFSLPAVMMAKEAVNRAYETTLAEGLLFERRLFHSLF 234

                         90       100
                 ....*....|....*....|..
gi 767960566 212 ALRDGQEGITAFLQKRKPVWSH 233
Cdd:PRK05862 235 ATEDQKEGMAAFVEKRKPVFKH 256
PRK07511 PRK07511
enoyl-CoA hydratase; Provisional
 50-229 6.20e-13

enoyl-CoA hydratase; Provisional


Pssm-ID: 181009 [Multi-domain]  Cd Length: 260  Bit Score: 66.17  E-value: 6.20e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566  50 ARQLDGIRNIVLSNPKKRNALSLAMLKSLQSDILHDADSNDLKVIIISAEGPVFSSGHDLKELTEEQGRDYHA------- 122
Cdd:PRK07511   7 SRREGSTLVLTLSNPGARNALHPDMYAAGIEALNTAERDPSIRAVVLTGAGGFFCAGGNLNRLLENRAKPPSVqaasidg 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 123 -----EVFQTCSK----------------------------------------------------------VALEMLFTG 139
Cdd:PRK07511  87 lhdwiRAIRAFPKpviaavegaaagagfslalacdllvaardakfvmayvkvgltpdgggswflaralprqLATELLLEG 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 140 EPISAQEALLHGLLSKVVPEAELQEETMRIARKIASLSRPVVSLGKATFYKQLPQDLGTAYYLTSQAMVDNLALRDGQEG 219
Cdd:PRK07511 167 KPISAERLHALGVVNRLAEPGQALAEALALADQLAAGSPNALARIKSLIADAPEATLAAQLEAERDHFVASLHHADALEG 246

                        250
                 ....*....|
gi 767960566 220 ITAFLQKRKP 229
Cdd:PRK07511 247 IAAFLEKRAP 256
PRK08260 PRK08260
enoyl-CoA hydratase; Provisional
 132-230 1.01e-12

enoyl-CoA hydratase; Provisional


Pssm-ID: 236206 [Multi-domain]  Cd Length: 296  Bit Score: 65.80  E-value: 1.01e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 132 ALEMLFTGEPISAQEALLHGLLSKVVPEAELQEETMRIARKIASLSRPV-VSLGKATFYKQL----PQDlgtAYYLTSQA 206
Cdd:PRK08260 174 ALEWVYSGRVFDAQEALDGGLVRSVHPPDELLPAARALAREIADNTSPVsVALTRQMMWRMAgadhPME---AHRVDSRA 250

                         90       100
                 ....*....|....*....|....
gi 767960566 207 MVDNLALRDGQEGITAFLQKRKPV 230
Cdd:PRK08260 251 IYSRGRSGDGKEGVSSFLEKRPAV 274
PRK05981 PRK05981
enoyl-CoA hydratase/isomerase;
132-228 1.88e-12

enoyl-CoA hydratase/isomerase;


Pssm-ID: 235661  Cd Length: 266  Bit Score: 64.75  E-value: 1.88e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 132 ALEMLFTGEPISAQEALLHGLLSKVVPEAELQEETMRIARKIAslSRPVVSLG--KATFYKQLPQDLGTAYYLTSQAMVD 209
Cdd:PRK05981 164 AMELSLLGEKLPAETALQWGLVNRVVDDAELMAEAMKLAHELA--NGPTVALGliRKLYWDSPENDFEEQLNLEREAQRI 241

                         90
                 ....*....|....*....
gi 767960566 210 NLALRDGQEGITAFLQKRK 228
Cdd:PRK05981 242 AGKTEDFKEGVGAFLQKRP 260
PRK06494 PRK06494
enoyl-CoA hydratase; Provisional
 130-232 1.94e-12

enoyl-CoA hydratase; Provisional


Pssm-ID: 180591 [Multi-domain]  Cd Length: 259  Bit Score: 64.68  E-value: 1.94e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 130 KVALEMLFTGEPISAQEALLHGLLSKVVPEAELQEETMRIARKIASLSRPVVSLGKATFYKQLPQDLGTAY-----YLTS 204
Cdd:PRK06494 153 KRAMGMILTGRRVTAREGLELGFVNEVVPAGELLAAAERWADDILACSPLSIRASKQAVYRGLEVSLEEAItaqrdYPAV 232

                         90       100
                 ....*....|....*....|....*...
gi 767960566 205 QAMVdnlALRDGQEGITAFLQKRKPVWS 232
Cdd:PRK06494 233 EARR---ASQDYIEGPKAFAEKRPPRWK 257
PRK05995 PRK05995
enoyl-CoA hydratase; Provisional
 59-231 3.83e-12

enoyl-CoA hydratase; Provisional


Pssm-ID: 235664 [Multi-domain]  Cd Length: 262  Bit Score: 63.79  E-value: 3.83e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566  59 IVLSNPKKRNALSLAMLKSLQSDILHDADSNDLKVIIISAEGPVFSSGHDLKELTEEQGRDYH---------AEVF---Q 126
Cdd:PRK05995  17 VTLNRPDVRNAFNETVIAELTAAFRALDADDSVRAVVLAGAGKAFCAGADLNWMKKMAGYSDDenradarrlADMLraiY 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 127 TCSK---------------------------------------------------------VALEMLFTGEPISAQEALL 149
Cdd:PRK05995  97 RCPKpviarvhgdayaggmglvaacdiavaadhavfclsevrlglipatispyviramgerAARRYFLTAERFDAAEALR 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 150 HGLLSKVVPEAELQEETMRIARKIASLSRPVVSLGKAT--------FYKQLPQDlgTAYYLTSQAMVDnlalrDGQEGIT 221
Cdd:PRK05995 177 LGLVHEVVPAEALDAKVDELLAALVANSPQAVRAGKRLvrdvagrpIDAALIAD--TASRIALIRATE-----EAREGVA 249

                        250
                 ....*....|
gi 767960566 222 AFLQKRKPVW 231
Cdd:PRK05995 250 AFLEKRKPAW 259
PRK06190 PRK06190
enoyl-CoA hydratase; Provisional
 54-207 4.38e-12

enoyl-CoA hydratase; Provisional


Pssm-ID: 235733  Cd Length: 258  Bit Score: 63.84  E-value: 4.38e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566  54 DGIRNIVLSNPKKRNALSLAMLKSLqSDILHDADSND-LKVIIISAEGPVFSSGHDLKEL-------------------- 112
Cdd:PRK06190  12 DRVRTLTLNRPEARNALSAALRRAL-FAALAEADADDdVDVVVLTGADPAFCAGLDLKELggdgsaygaqdalpnpspaw 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 113 ------------------------------TEEQGR--DYHAEV--------FQTCSKV-----ALEMLFTGEPISAQEA 147
Cdd:PRK06190  91 pamrkpvigaingaavtgglelalacdiliASERARfaDTHARVgilpgwglSVRLPQKvgigrARRMSLTGDFLDAADA 170

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 148 LLHGLLSKVVPEAELQEETMRIARKIASLSRPVVSLGKATFYKQLPQDLGTAYYLTSQAM 207
Cdd:PRK06190 171 LRAGLVTEVVPHDELLPRARRLAASIAGNNPAAVRALKASYDDGAAAQTGDALALEAEAA 230
PRK06495 PRK06495
enoyl-CoA hydratase/isomerase family protein;
54-231 4.40e-12

enoyl-CoA hydratase/isomerase family protein;


Pssm-ID: 168580 [Multi-domain]  Cd Length: 257  Bit Score: 63.95  E-value: 4.40e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566  54 DGIRNIVLSNPKKrNALSLAMLKSLQSDILHDADSNDLKVIIISAEGPVFSSGHDLK---ELTEEQGrDYHA------EV 124
Cdd:PRK06495  12 DHVAVVTLDNPPV-NALSRELRDELIAVFDEISERPDVRVVVLTGAGKVFCAGADLKgrpDVIKGPG-DLRAhnrrtrEC 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 125 FQT---CSK------------------------VALE-------------------------------MLFTGEPISAQE 146
Cdd:PRK06495  90 FHAireCAKpviaavngpalgaglglvascdiiVASEnavfglpeidvglagggkhamrlfghsltrrMMLTGYRVPAAE 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 147 ALLHGLLSKVVPEAELQEETMRIARKIASLSRPVVSLGKATFykqlpqdlgtayyltsqAMVDNLALRDG---------- 216
Cdd:PRK06495 170 LYRRGVIEACLPPEELMPEAMEIAREIASKSPLATRLAKDAL-----------------NTIENMSLRDGyryeqditak 232

                        250       260
                 ....*....|....*....|..
gi 767960566 217 -------QEGITAFLQKRKPVW 231
Cdd:PRK06495 233 laktedaKEAQRAFLEKRPPVF 254
PRK07938 PRK07938
enoyl-CoA hydratase family protein;
135-229 2.27e-11

enoyl-CoA hydratase family protein;


Pssm-ID: 181174  Cd Length: 249  Bit Score: 61.53  E-value: 2.27e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 135 MLFTGEPISAQEALLHGLLSKVVPEAELQEETMRIARKIASLSRPVVSLGKATFYKQLPQDLGTAYYL----TSQAmvdN 210
Cdd:PRK07938 155 LFFTAATITAAELHHFGSVEEVVPRDQLDEAALEVARKIAAKDTRVIRAAKEALNGIDPQDVERSYRWeqgfTFEL---N 231

                         90
                 ....*....|....*....
gi 767960566 211 LAlRDGQEGITAFLQKRKP 229
Cdd:PRK07938 232 LA-GVSDEHRDAFVEKRKA 249
PRK06563 PRK06563
crotonase/enoyl-CoA hydratase family protein;
51-230 2.36e-11

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 180625 [Multi-domain]  Cd Length: 255  Bit Score: 61.52  E-value: 2.36e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566  51 RQLDG-IRNIVLSNPKKRNALSLAMLKSLqSDILHDADSND-LKVIIISAEGPVFSSGHDLKELTE----------EQGR 118
Cdd:PRK06563   3 RERRGhVLLIGLDRPAKRNAFDSAMLDDL-ALALGEYEADDeLRVAVLFAHGEHFTAGLDLADVAPklaaggfpfpEGGI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 119 DYHAEVFQTCSK------------VALEM----------------------------------------------LFTGE 140
Cdd:PRK06563  82 DPWGTVGRRLSKplvvavqgycltLGIELmlaadivvaadntrfaqlevqrgilpfggatlrfpqaagwgnamryLLTGD 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 141 PISAQEALLHGLLSKVVPEAELQEETMRIARKIASL-----------SRPVVSLGKATFYKQLPQDLgtAYYLTSQamvd 209
Cdd:PRK06563 162 EFDAQEALRLGLVQEVVPPGEQLERAIELAERIARAaplgvqatlasARAAVREGEAAAAAQLPPEL--RPLFTSE---- 235

                        250       260
                 ....*....|....*....|.
gi 767960566 210 nlalrDGQEGITAFLQKRKPV 230
Cdd:PRK06563 236 -----DAKEGVQAFLERRPAR 251
PRK07396 PRK07396
dihydroxynaphthoic acid synthetase; Validated
 54-229 2.55e-11

dihydroxynaphthoic acid synthetase; Validated


Pssm-ID: 180958 [Multi-domain]  Cd Length: 273  Bit Score: 61.83  E-value: 2.55e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566  54 DGIRNIVLSNPKKRNALSLAMLKSLqSDILHDA-DSNDLKVIIISAEGP-VFSSGHDLK------ELTEEQ--------- 116
Cdd:PRK07396  21 DGIAKITINRPEVRNAFRPKTVKEM-IDAFADArDDDNIGVIILTGAGDkAFCSGGDQKvrgyggYVDDDGvprlnvldl 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 117 ----------------------GRDYH--------AE--VF-QTCSKV--------------------ALEMLFTGEPIS 143
Cdd:PRK07396 100 qrlirtcpkpviamvagyaiggGHVLHlvcdltiaADnaIFgQTGPKVgsfdggygasylarivgqkkAREIWFLCRQYD 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 144 AQEALLHGLLSKVVPEAELQEETMRIARKIASLSRPVVSLGKATF---------YKQLPQDLGTAYYLTSQAmvdnlalr 214
Cdd:PRK07396 180 AQEALDMGLVNTVVPLADLEKETVRWCREMLQNSPMALRCLKAALnadcdgqagLQELAGNATMLFYMTEEA-------- 251

                        250
                 ....*....|....*
gi 767960566 215 dgQEGITAFLQKRKP 229
Cdd:PRK07396 252 --QEGRNAFNEKRQP 264
PRK06210 PRK06210
enoyl-CoA hydratase; Provisional
 132-229 2.67e-11

enoyl-CoA hydratase; Provisional


Pssm-ID: 180472  Cd Length: 272  Bit Score: 61.64  E-value: 2.67e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 132 ALEMLFTGEPISAQEALLHGLLSKVVPEAELQEETMRIARKIASLSRPV-VSLGKATFYKQLPQDLGTAYYLTSQAMVDN 210
Cdd:PRK06210 169 ALDLLLSARTFYAEEALRLGLVNRVVPPDELMERTLAYAEDLARNVSPAsMAVIKRQLYEDAFQTLAEATARANREMHES 248

                         90
                 ....*....|....*....
gi 767960566 211 LALRDGQEGITAFLQKRKP 229
Cdd:PRK06210 249 LQRPDFIEGVASFLEKRPP 267
PRK09076 PRK09076
enoyl-CoA hydratase; Provisional
 135-231 4.35e-11

enoyl-CoA hydratase; Provisional


Pssm-ID: 236373 [Multi-domain]  Cd Length: 258  Bit Score: 61.09  E-value: 4.35e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 135 MLFTGEPISAQEALLHGLLSKVVPEAELQEETMRIARKIASLSRPVVslgkaTFYKQLPQD-----LGTAYYLTSQAMVD 209
Cdd:PRK09076 159 MILCGERVDAATALRIGLVEEVVEKGEAREAALALAQKVANQSPSAV-----AACKTLIQAarngpRAAALALERELFVD 233

                         90       100
                 ....*....|....*....|..
gi 767960566 210 NLALRDGQEGITAFLQKRKPVW 231
Cdd:PRK09076 234 LFDTEDQREGVNAFLEKRAPQW 255
PRK05980 PRK05980
crotonase/enoyl-CoA hydratase family protein;
130-230 5.23e-11

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 180335 [Multi-domain]  Cd Length: 260  Bit Score: 60.93  E-value: 5.23e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 130 KVALEMLFTGEPISAQEALLHGLLSKVVPEAELQEETMRIARKIASLSRPVVSLGKATFYKQLPQDLGTAYYLTSQAMVD 209
Cdd:PRK05980 159 KRALELLLTGDAFSAERALEIGLVNAVVPHEELLPAARALARRIIRHSPVAVAAILTAVTRGLNLSIAEGLLIESEQFAR 238

                         90       100
                 ....*....|....*....|.
gi 767960566 210 NLALRDGQEGITAFLQKRKPV 230
Cdd:PRK05980 239 MAGSADLREGLAAWIERRRPA 259
PRK06127 PRK06127
enoyl-CoA hydratase; Provisional
 54-232 7.58e-11

enoyl-CoA hydratase; Provisional


Pssm-ID: 235705  Cd Length: 269  Bit Score: 60.49  E-value: 7.58e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566  54 DGIRNIVLSNPKKRNALSLAMLKSLqSDILHDA-DSNDLKVIIISAEG-PVFSSGHDLKELTEEQGRDYHAEVFQT---- 127
Cdd:PRK06127  19 GGLGRITFNNPARHNAMSLDMWEAL-PQALAAAeDDDAIRVVVLTGAGeKAFVSGADISQFEESRSDAEAVAAYEQavea 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 128 -------------------------------------------------------------CSKV----ALEMLFTGEPI 142
Cdd:PRK06127  98 aqaaladyakptiacirgycigggmgialacdiriaaedsrfgipaarlglgygydgvknlVDLVgpsaAKDLFYTARRF 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 143 SAQEALLHGLLSKVVPEAELQEETMRIARKIASLSRPVVSLGKATFyKQLPQDLGTAYYLTSQAMVDN-LALRDGQEGIT 221
Cdd:PRK06127 178 DAAEALRIGLVHRVTAADDLETALADYAATIAGNAPLTLRAAKRAI-AELLKDEPERDMAACQALVAAcFDSEDYREGRA 256

                        250
                 ....*....|.
gi 767960566 222 AFLQKRKPVWS 232
Cdd:PRK06127 257 AFMEKRKPVFK 267
PRK08321 PRK08321
1,4-dihydroxy-2-naphthoyl-CoA synthase;
126-235 1.23e-10

1,4-dihydroxy-2-naphthoyl-CoA synthase;


Pssm-ID: 181386  Cd Length: 302  Bit Score: 60.04  E-value: 1.23e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 126 QTCSKVALEMLFTGEPISAQEALLHGLLSKVVPEAELQEETMRIARKIASLSRPVVSLGKATFykQLPQD--------LG 197
Cdd:PRK08321 191 QVGQKFAREIFFLGRTYSAEEAHDMGAVNAVVPHAELETEALEWAREINGKSPTAMRMLKYAF--NLTDDglvgqqlfAG 268

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 767960566 198 TAY---YLTSQAmvdnlalrdgQEGITAFLQKRKPVWSHEP 235
Cdd:PRK08321 269 EATrlaYMTDEA----------QEGRDAFLEKRDPDWSDFP 299
PRK03580 PRK03580
crotonobetainyl-CoA hydratase;
131-231 1.23e-10

crotonobetainyl-CoA hydratase;


Pssm-ID: 179599 [Multi-domain]  Cd Length: 261  Bit Score: 59.71  E-value: 1.23e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 131 VALEMLFTGEPISAQEALLHGLLSKVVPEAELQEETMRIARKIASLSRPVVSLGKATFYKQLPQDLGTAY-YLTSQAM-- 207
Cdd:PRK03580 154 IANEMVMTGRRMDAEEALRWGIVNRVVPQAELMDRARELAQQLVNSAPLAIAALKEIYRETSEMPVEEAYrYIRSGVLkh 233

                         90       100
                 ....*....|....*....|....*
gi 767960566 208 VDN-LALRDGQEGITAFLQKRKPVW 231
Cdd:PRK03580 234 YPSvLHSEDALEGPRAFAEKRDPVW 258
PRK07327 PRK07327
enoyl-CoA hydratase/isomerase family protein;
51-229 1.33e-10

enoyl-CoA hydratase/isomerase family protein;


Pssm-ID: 235991  Cd Length: 268  Bit Score: 59.65  E-value: 1.33e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566  51 RQLDGIRNIVLSNPKKRNALSLAMLKSLqSDILHDADSN-DLKVIIISAEGPVFSSGHDLkELTEEQGRDYH--AEVFQ- 126
Cdd:PRK07327  17 RPPPGVLEIVLNGPGALNAADARMHREL-ADIWRDVDRDpDVRVVLIRGEGKAFSAGGDL-ALVEEMADDFEvrARVWRe 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 127 ---------TCSK----------------VAL------------------------------------EM------LFTG 139
Cdd:PRK07327  95 ardlvynviNCDKpivsaihgpavgaglvAALladisiaakdariidghtrlgvaagdhaaivwpllcGMakakyyLLLC 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 140 EPISAQEALLHGLLSKVVPEAELQEETMRIARKIASLSRPVVSLGKATfykqlpqdLGTAYYLTSQAMVDNLALR----- 214
Cdd:PRK07327 175 EPVSGEEAERIGLVSLAVDDDELLPKALEVAERLAAGSQTAIRWTKYA--------LNNWLRMAGPTFDTSLALEfmgfs 246

                        250
                 ....*....|....*..
gi 767960566 215 --DGQEGITAFLQKRKP 229
Cdd:PRK07327 247 gpDVREGLASLREKRAP 263
PRK08252 PRK08252
crotonase/enoyl-CoA hydratase family protein;
54-231 1.40e-10

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 181325 [Multi-domain]  Cd Length: 254  Bit Score: 59.62  E-value: 1.40e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566  54 DGIRNIVLSNPKKRNALSLAMLKSLqSDILHDADSN-DLKVIIISAEGPVFSSGHDLK-----ELTEEQGRDYHAEVFQT 127
Cdd:PRK08252  11 GRVLIITINRPEARNAVNAAVAQGL-AAALDELDADpDLSVGILTGAGGTFCAGMDLKafargERPSIPGRGFGGLTERP 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 128 CSK----------------------------------------------------------VALEMLFTGEPISAQEALL 149
Cdd:PRK08252  90 PRKpliaavegyalaggfelalacdlivaardakfglpevkrglvaagggllrlprripyhIAMELALTGDMLTAERAHE 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 150 HGLLSKVVPEAELQEETMRIARKIASLSRPVVSLGKATFYKQLPQDLGTAYYLTSQAMVDNLALRDGQEGITAFLQKRKP 229
Cdd:PRK08252 170 LGLVNRLTEPGQALDAALELAERIAANGPLAVAASKRIVVESGDWSEDEMFARQRELIAPVFTSADAKEGATAFAEKRAP 249


                 ..
gi 767960566 230 VW 231
Cdd:PRK08252 250 VW 251
PRK07799 PRK07799
crotonase/enoyl-CoA hydratase family protein;
59-231 5.19e-10

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 181122 [Multi-domain]  Cd Length: 263  Bit Score: 57.80  E-value: 5.19e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566  59 IVLSNPKKRNALSLAMLKslqsdILHDA----DSND-LKVIIISAEGPVFSSGHDLKELTEEQGRDYHA----------- 122
Cdd:PRK07799  18 VTMNRPEARNALSTEMLR-----IMVDAwdrvDNDPdIRSCILTGAGGAFCAGMDLKAATKKPPGDSFKdgsydpsrida 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 123 ------------------------EVFQTCS-----------------------------------KVALEMLFTGEPIS 143
Cdd:PRK07799  93 llkgrrltkpliaavegpaiaggtEILQGTDirvagesakfgiseakwslfpmggsavrlvrqipyTVACDLLLTGRHIT 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 144 AQEALLHGLLSKVVPEAELQEETMRIARKIASLSRPVVSLGKATFYK----------QLPQDLGTAYYLTSqamvdnlal 213
Cdd:PRK07799 173 AAEAKEIGLIGHVVPDGQALDKALELAELINANGPLAVQAILRTIREtegmheneafKIDTKIGIPVFLSE--------- 243

                        250
                 ....*....|....*...
gi 767960566 214 rDGQEGITAFLQKRKPVW 231
Cdd:PRK07799 244 -DAKEGPRAFAEKRAPNF 260
PRK08258 PRK08258
enoyl-CoA hydratase family protein;
132-231 9.21e-10

enoyl-CoA hydratase family protein;


Pssm-ID: 181329  Cd Length: 277  Bit Score: 57.28  E-value: 9.21e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 132 ALEMLFTGEPISAQEALLHGLLSKVVPEAELQEETMRIARKIAslSRPVVSLG--KATFYKQLPQDLGTAYYLTSQAMVD 209
Cdd:PRK08258 175 ASELLYTGRSMSAEEGERWGFFNRLVEPEELLAEAQALARRLA--AGPTFAHGmtKTMLHQEWDMGLEEAIEAEAQAQAI 252

                         90       100
                 ....*....|....*....|..
gi 767960566 210 NLALRDGQEGITAFLQKRKPVW 231
Cdd:PRK08258 253 CMQTEDFRRAYEAFVAKRKPVF 274
PLN02600 PLN02600
enoyl-CoA hydratase
 55-234 2.08e-09

enoyl-CoA hydratase


Pssm-ID: 178210 [Multi-domain]  Cd Length: 251  Bit Score: 55.97  E-value: 2.08e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566  55 GIRNIVLSNPKKRNALSLAMLKSLQSDILHDADSNDLKVIIISAEGP-VFSSGHDLKE---LTEEQGRDYHAEVFQTCS- 129
Cdd:PLN02600   4 GIVELRLDRPEAKNAIGKEMLRGLRSAFEKIQADASARVVMLRSSVPgVFCAGADLKErrkMSPSEVQKFVNSLRSTFSs 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 130 ---------------------------------------------------------------KVALEMLFTGEPISAQE 146
Cdd:PLN02600  84 lealsiptiavvegaalggglelalscdlricgeeavfglpetglaiipgaggtqrlprlvgrSRAKELIFTGRRIGARE 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 147 ALLHGLLSKVVPEAELQEETMRIARKIASLSRPVVSLGKATFYKQLPQDLGTAYYLTSQAMVDNLALRDGQEGITAFLQK 226
Cdd:PLN02600 164 AASMGLVNYCVPAGEAYEKALELAQEINQKGPLAIKMAKKAINEGSEVDMASGLEIEEECYEQVLKTKDRLEGLAAFAEK 243


                 ....*...
gi 767960566 227 RKPVWSHE 234
Cdd:PLN02600 244 RKPVYTGK 251
PLN02921 PLN02921
naphthoate synthase
 130-235 7.67e-09

naphthoate synthase


Pssm-ID: 178509 [Multi-domain]  Cd Length: 327  Bit Score: 54.79  E-value: 7.67e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 130 KVALEMLFTGEPISAQEALLHGLLSKVVPEAELQEETMRIARKIASLSRPVVSLGKATF---------YKQLPQDLGTAY 200
Cdd:PLN02921 220 KKAREMWFLARFYTASEALKMGLVNTVVPLDELEGETVKWCREILRNSPTAIRVLKSALnaaddghagLQELGGNATLLF 299

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 767960566 201 YLTSQamvdnlalrdGQEGITAFLQKRKPVWSHEP 235
Cdd:PLN02921 300 YGSEE----------GNEGRTAYLEGRAPDFSKFP 324
PRK09120 PRK09120
p-hydroxycinnamoyl CoA hydratase/lyase; Validated
 54-229 8.86e-09

p-hydroxycinnamoyl CoA hydratase/lyase; Validated


Pssm-ID: 236383  Cd Length: 275  Bit Score: 54.63  E-value: 8.86e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566  54 DGIRNIVLSNPKKRNALSLAM-------LKSLQSDilhdadsNDLKVIIISAEGPVFSSGHDLKEL---TEEQGRDYHAE 123
Cdd:PRK09120  16 DGIAWVTLNRPEKRNAMSPTLnremidvLDALEFD-------DDAGVLVLTGAGDAWSAGMDLKEYfreTDAQPEILQER 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 124 VFQTC-----------------------------------------------------------SKV---------ALEM 135
Cdd:PRK09120  89 IRREAygwwrrlrwyqkptiamvngwcfgggfsplvacdlaiaadeaqfglseinwgippgggvSKAmadtvghrdALYY 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 136 LFTGEPISAQEALLHGLLSKVVPEAELQEETMRIARKIASLSRPVVSLGKATF--YKQLPQDLGTAYYltsQAMVDNLAL 213
Cdd:PRK09120 169 IMTGETFTGRKAAEMGLVNESVPLAQLRARTRELAAKLLEKNPVVLRAAKDGFkrVRELTWDQAEDYL---YAKLEQANS 245

                        250       260
                 ....*....|....*....|..
gi 767960566 214 RDG----QEGITAFLQKR--KP 229
Cdd:PRK09120 246 LDPeggrEEGLKQFLDDKsyKP 267
PRK07509 PRK07509
crotonase/enoyl-CoA hydratase family protein;
54-112 2.89e-07

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 181008 [Multi-domain]  Cd Length: 262  Bit Score: 49.88  E-value: 2.89e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 767960566  54 DGIRNIVLSNPKKRNALSLAMLKSLQSDILHDADSNDLKVIIISAEGPVFSSGHDLKEL 112
Cdd:PRK07509  11 DGIADVRLNRPDKMNALDFAMFEELIATIKRLKKDRGIRAVILSGEGGAFCAGLDVKSV 69
PRK06072 PRK06072
enoyl-CoA hydratase; Provisional
 54-229 6.32e-07

enoyl-CoA hydratase; Provisional


Pssm-ID: 168377 [Multi-domain]  Cd Length: 248  Bit Score: 49.01  E-value: 6.32e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566  54 DGIRNIVLSNPKKRNALSLAMLKSLQSdILHDADSN-DLKVIIISAEGPVFSSGHDLKELTEEQGRDYHAEVFQTCSKV- 131
Cdd:PRK06072   8 EGYAIVTMSRPDKLNALNLEMRNEFIS-KLKQINADpKIRVVIVTGEGRAFCVGADLSEFAPDFAIDLRETFYPIIREIr 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 132 --------------------------------------------------------------ALEMLFTGEPISAQEALL 149
Cdd:PRK06072  87 fsdkiyisaingvtagacigialstdfkfasrdvkfvtafqrlglasdtgvayfllkltgqrFYEILVLGGEFTAEEAER 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 150 HGLLsKVVPEAELQEETMriARKIASLSRPVVSLGKATFYKQLPQDLGTAYYLTSqAMVDNLAL-RDGQEGITAFLQKRK 228
Cdd:PRK06072 167 WGLL-KISEDPLSDAEEM--ANRISNGPFQSYIAAKRMINLVLYNDLEEFLEYES-AIQGYLGKtEDFKEGISSFKEKRE 242


                 .
gi 767960566 229 P 229
Cdd:PRK06072 243 P 243
PRK07468 PRK07468
crotonase/enoyl-CoA hydratase family protein;
55-231 6.36e-07

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 180987 [Multi-domain]  Cd Length: 262  Bit Score: 48.90  E-value: 6.36e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566  55 GIRNIVLSNPKKRNALSLAMLKSLQSDILHDADSNDLKVIIISAEGPVFSSGHDLKELTEE------------------- 115
Cdd:PRK07468  14 GVATLTLNRPEKHNALSARMIAELTTAARRLAADAAVRVVVLTGAGKSFCAGGDLGWMRAQmtadratrieearrlamml 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 116 --------------QGRDYHAEV--FQTCSKV----------------------------------ALEMLFTGEPISAQ 145
Cdd:PRK07468  94 kalndlpkpligriQGQAFGGGVglISVCDVAiavsgarfgltetrlglipatispyvvarmgeanARRVFMSARLFDAE 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 146 EALLHGLLSKVVPEAELQEEtmrIARKIASLSrpVVSLGKATFYKQLPQDLGT-----AYYLTSQAMVDNLALRDGQEGI 220
Cdd:PRK07468 174 EAVRLGLLSRVVPAERLDAA---VEAEVTPYL--SCAPGAVAAAKALVRALGApideaVIDATIEALADTWETEEAREGI 248

                        250
                 ....*....|.
gi 767960566 221 TAFLQKRKPVW 231
Cdd:PRK07468 249 AAFFDKRAPAW 259
ECH_2 pfam16113
Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: ...
 56-127 6.97e-07

Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: enoyl-CoA hydratase, napthoate synthase, carnitate racemase, 3-hydroxybutyryl-CoA dehydratase and dodecanoyl-CoA delta-isomerase. This family differs from pfam00378 in the structure of it's C-terminus.


Pssm-ID: 465024 [Multi-domain]  Cd Length: 331  Bit Score: 49.01  E-value: 6.97e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767960566   56 IRNIVLSNPKKRNALSLAMLKSLQSDILHDADSNDLKVIIISAEGP-VFSSGHDLKELTE---EQGRDYHAEVFQT 127
Cdd:pfam16113   1 VGVITLNRPKALNALNLEMVRALLAALKAWEDDPAVKLVVLKGAGErAFCAGGDVRALYEaakAGGGEAGRDFFRE 76
PRK08150 PRK08150
crotonase/enoyl-CoA hydratase family protein;
54-175 7.54e-07

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 181254  Cd Length: 255  Bit Score: 48.48  E-value: 7.54e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566  54 DGIRNIVLSNPKKRNALSLAMLKSLQsDILHDAdSNDLKVIIISAEGPVFSSGHDLKELTEEQG-------RDYHaEVFQ 126
Cdd:PRK08150  10 GGVATIGLNRPAKRNALNDGLIAALR-AAFARL-PEGVRAVVLHGEGDHFCAGLDLSELRERDAgegmhhsRRWH-RVFD 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 127 T------------------------CS---KVA----------------------------------LEMLFTGEPISAQ 145
Cdd:PRK08150  87 KiqygrvpviaalhgavvggglelaSAahiRVAdestyfalpegqrgifvggggsvrvprligvarmTDMMLTGRVYDAQ 166

                        170       180       190
                 ....*....|....*....|....*....|
gi 767960566 146 EALLHGLLSKVVPEAELQEETMRIARKIAS 175
Cdd:PRK08150 167 EGERLGLAQYLVPAGEALDKAMELARRIAQ 196
PRK05870 PRK05870
enoyl-CoA hydratase; Provisional
 54-119 9.43e-07

enoyl-CoA hydratase; Provisional


Pssm-ID: 180298  Cd Length: 249  Bit Score: 48.18  E-value: 9.43e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767960566  54 DGIRNIVLSNPKKRNALSLAMLKSLQSDILHDADSNDLKVIIISAEGPVFSSGHDLKELTEEQGRD 119
Cdd:PRK05870  11 DGVALITVNDPDRRNAVTAEMSAQLRAAVAAAEADPDVHALVVTGAGKAFCAGADLTALGAAPGRP 76
PRK05864 PRK05864
enoyl-CoA hydratase; Provisional
 129-232 1.19e-06

enoyl-CoA hydratase; Provisional


Pssm-ID: 168278 [Multi-domain]  Cd Length: 276  Bit Score: 48.29  E-value: 1.19e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 129 SKVALEMLFTGEPISAQEALLHGLLSKVVPEAELQEETMRIARKIASLSRPVVSLGKATFYKQLpqDLGTAYYLTSQAMV 208
Cdd:PRK05864 168 SSRAFEIMLTGRDVDAEEAERIGLVSRQVPDEQLLDTCYAIAARMAGFSRPGIELTKRTLWSGL--DAASLEAHMQAEGL 245

                         90       100
                 ....*....|....*....|....*...
gi 767960566 209 DNLALR----DGQEGITAFLQKRKPVWS 232
Cdd:PRK05864 246 GQLFVRlltaNFEEAVAARAEKRPPVFT 273
PLN02888 PLN02888
enoyl-CoA hydratase
 55-199 3.44e-06

enoyl-CoA hydratase


Pssm-ID: 215480  Cd Length: 265  Bit Score: 46.67  E-value: 3.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566  55 GIRNIVLSNPKKRNALSLAMLKSLqSDILHDADSND-LKVIIISAEGPVFSSGHDLK----------------------- 110
Cdd:PLN02888  19 GIATITINRPKALNALTRPMMVEL-AAAFKRLDEDDsVKVIILTGSGRAFCSGVDLTaaeevfkgdvkdvetdpvaqmer 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 111 ------------------EL----------TEEQGRDYHAE--VF------QTCSKV-----ALEMLFTGEPISAQEALL 149
Cdd:PLN02888  98 crkpiigaingfaitagfEIalacdilvasRGAKFIDTHAKfgIFpswglsQKLSRIiganrAREVSLTAMPLTAETAER 177

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 767960566 150 HGLLSKVVPEAELQEETMRIARKIASLSRPVVSLGKATFYKQLPQDLGTA 199
Cdd:PLN02888 178 WGLVNHVVEESELLKKAREVAEAIIKNNQGMVLRYKSVINDGLKLDLGHA 227
PRK08140 PRK08140
enoyl-CoA hydratase; Provisional
 132-232 6.38e-06

enoyl-CoA hydratase; Provisional


Pssm-ID: 236163  Cd Length: 262  Bit Score: 46.06  E-value: 6.38e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 132 ALEMLFTGEPISAQEALLHGLLSKVVPEAELQEETMRIARKIASlsRPVVSLG--KATFYKQLPQDLGTAYYLTSQAMVD 209
Cdd:PRK08140 160 ALGLALLGEKLSAEQAEQWGLIWRVVDDAALADEAQQLAAHLAT--QPTRGLAliKQAMNASATNTLDAQLDLERDLQRE 237

                         90       100
                 ....*....|....*....|...
gi 767960566 210 NLALRDGQEGITAFLQKRKPVWS 232
Cdd:PRK08140 238 AGRSADYAEGVSAFLEKRAPRFT 260
PRK07659 PRK07659
enoyl-CoA hydratase; Provisional
 54-234 8.77e-06

enoyl-CoA hydratase; Provisional


Pssm-ID: 236073 [Multi-domain]  Cd Length: 260  Bit Score: 45.41  E-value: 8.77e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566  54 DGIRNIVLSNPKKRNALSLAMLKSLQsDILHDADSNDLKVIIISAEGPVFSSGHDLKELTEEQGRDYHAEVFQTCSKVAL 133
Cdd:PRK07659  14 GRVATIMLNRPEALNALDEPMLKELL-QALKEVAESSAHIVVLRGNGRGFSAGGDIKMMLSSNDESKFDGVMNTISEIVV 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 134 --------------------------------------------------------------------EMLFTGEPISAQ 145
Cdd:PRK07659  93 tlytmpkltisaihgpaaglglsialtadyviadisaklamnfigiglipdggghfflqkrvgenkakQIIWEGKKLSAT 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 146 EALLHGLLSKVVpeaelQEETMRIAR-KIAS-LSRPVVSL--GKATFYKQLPQDLGTAYYLTSQAMVDNLALRDGQEGIT 221
Cdd:PRK07659 173 EALDLGLIDEVI-----GGDFQTAAKqKISEwLQKPLKAMieTKQIYCELNRSQLEQVLQLEKRAQYAMRQTADHKEGIR 247

                        250
                 ....*....|...
gi 767960566 222 AFLQKRKPVWSHE 234
Cdd:PRK07659 248 AFLEKRLPVFKGE 260
PRK08272 PRK08272
crotonase/enoyl-CoA hydratase family protein;
54-178 1.31e-05

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 236213  Cd Length: 302  Bit Score: 45.03  E-value: 1.31e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566  54 DGIRNIVLSNPKKRNALSLAMLKSLQSDILHDADSNDLKVIIISAEGPVFSSGHDLKELTEEQG---------------- 117
Cdd:PRK08272  18 GRIARITLNRPEKGNAITADTPLELRAAVERADLDPGVHVILVSGAGKGFCAGYDLSAYAEGSSsgggggaypgkrqavn 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 118 ----------RDYH-----AEVFQT---CSK----------------VAL------------------------------ 133
Cdd:PRK08272  98 hlpddpwdpmIDYQmmsrfVRGFMSlwhAHKptvakvhgycvaggtdIALhcdqviaaddakigypptrvwgvpatgmwa 177

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767960566 134 ---------EMLFTGEPISAQEALLHGLLSKVVPEAELQEETMRIARKIASLSR 178
Cdd:PRK08272 178 yrlgpqrakRLLFTGDCITGAQAAEWGLAVEAVPPEELDERTERLVERIAAVPV 231
PLN02874 PLN02874
3-hydroxyisobutyryl-CoA hydrolase-like protein
 54-203 1.45e-05

3-hydroxyisobutyryl-CoA hydrolase-like protein


Pssm-ID: 178462 [Multi-domain]  Cd Length: 379  Bit Score: 45.18  E-value: 1.45e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566  54 DGIRNIVLSNPKKRNALSLAMLkSLQSDILHDADSND-LKVIIISAEGPVFSSGHDLKELTEEQGRDyhaevfQTCSKVA 132
Cdd:PLN02874  19 GRVRVITLNRPRQLNVISLSVV-SLLAEFLEQWEKDDsVELIIIKGAGRAFSAGGDLKMFYDGRESD------DSCLEVV 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 133 LEMLFTGEPISA----QEALLHGLL-----SKVVPeaelqeETMRIARKIASLSRPVVSLGKAT------FYKQLPQDLG 197
Cdd:PLN02874  92 YRMYWLCYHIHTykktQVALVHGLVmgggaGLMVP------MKFRVVTEKTVFATPEASVGFHTdcgfsyILSRLPGHLG 165


                 ....*.
gi 767960566 198 TAYYLT 203
Cdd:PLN02874 166 EYLALT 171
PLN02664 PLN02664
enoyl-CoA hydratase/delta3,5-delta2,4-dienoyl-CoA isomerase
 132-232 3.59e-05

enoyl-CoA hydratase/delta3,5-delta2,4-dienoyl-CoA isomerase


Pssm-ID: 178269 [Multi-domain]  Cd Length: 275  Bit Score: 43.74  E-value: 3.59e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 132 ALEMLFTGEPISAQEALLHGLLSKVVPEAELQEETMR-IARKIASLSRPVVSLGKATFY--KQLPQDLGTAYYLT-SQAM 207
Cdd:PLN02664 172 AMELALTGRRFSGSEAKELGLVSRVFGSKEDLDEGVRlIAEGIAAKSPLAVTGTKAVLLrsRELSVEQGLDYVATwNSAM 251

                         90       100
                 ....*....|....*....|....*
gi 767960566 208 vdnLALRDGQEGITAFLQKRKPVWS 232
Cdd:PLN02664 252 ---LVSDDLNEAVSAQIQKRKPVFA 273
PRK08259 PRK08259
crotonase/enoyl-CoA hydratase family protein;
132-176 5.44e-05

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 236205  Cd Length: 254  Bit Score: 42.96  E-value: 5.44e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 767960566 132 ALEMLFTGEPISAQEALLHGLLSKVVPEAELQEETMRIARKIASL 176
Cdd:PRK08259 154 AMDLILTGRPVDADEALAIGLANRVVPKGQARAAAEELAAELAAF 198
PRK06143 PRK06143
enoyl-CoA hydratase; Provisional
 135-186 8.06e-05

enoyl-CoA hydratase; Provisional


Pssm-ID: 180423  Cd Length: 256  Bit Score: 42.71  E-value: 8.06e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 767960566 135 MLFTGEPISAQEALLHGLLSKVVPEAELQEETMRIARKIASLSRPVVSLGKA 186
Cdd:PRK06143 163 LLLTGETIDAAQALAWGLVDRVVPLAELDAAVERLAASLAGCGPQALRQQKR 214
PRK07854 PRK07854
enoyl-CoA hydratase; Provisional
 59-109 9.34e-05

enoyl-CoA hydratase; Provisional


Pssm-ID: 236115 [Multi-domain]  Cd Length: 243  Bit Score: 42.32  E-value: 9.34e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 767960566  59 IVLSNPKKRNALSLAMLKSLQSDIlHDADSNDLKVIIISAEGPVFSSGHDL 109
Cdd:PRK07854  13 IELQRPERRNALNAELCEELREAV-RKAVDESARAIVLTGQGTVFCAGADL 62
PRK07827 PRK07827
enoyl-CoA hydratase family protein;
54-231 1.07e-04

enoyl-CoA hydratase family protein;


Pssm-ID: 236109 [Multi-domain]  Cd Length: 260  Bit Score: 42.36  E-value: 1.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566  54 DGIRNIVLSNPKKRNALSLAMLKSLQSDILHDADSNDLKVIIISAEGPVFSSGHDLKELTEEQGRDYHAEVFQT------ 127
Cdd:PRK07827  14 GGVATLTLDSPHNRNALSARLVAQLHDGLRAAAADPAVRAVVLTHTGGTFCAGADLSEAGGGGGDPYDAAVARAremtal 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 128 -----------------------------C----------------------------------SKVALEMLFTGEPISA 144
Cdd:PRK07827  94 lraivelpkpviaaidghvraggfglvgaCdivvagpestfaltearigvapaiisltllprlsPRAAARYYLTGEKFGA 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767960566 145 QEALLHGLLSKVVPEAElqeetmriarkiASLSRPVVSLGKATfykqlPQDLGTAYYLTSQAMVDNLALR---------- 214
Cdd:PRK07827 174 AEAARIGLVTAAADDVD------------AAVAALLADLRRGS-----PQGLAESKALTTAAVLAGFDRDaeelteesar 236

                        250       260
                 ....*....|....*....|..
gi 767960566 215 -----DGQEGITAFLQKRKPVW 231
Cdd:PRK07827 237 lfvsdEAREGMTAFLQKRPPRW 258
PRK06023 PRK06023
crotonase/enoyl-CoA hydratase family protein;
132-174 2.43e-04

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 168351  Cd Length: 251  Bit Score: 41.32  E-value: 2.43e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 767960566 132 ALEMLFTGEPISAQEALLHGLLSKVVPEAELQEETMRIARKIA 174
Cdd:PRK06023 158 AFALLALGEGFSAEAAQEAGLIWKIVDEEAVEAETLKAAEELA 200
PRK06213 PRK06213
crotonase/enoyl-CoA hydratase family protein;
54-114 5.48e-04

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 235744  Cd Length: 229  Bit Score: 39.96  E-value: 5.48e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767960566  54 DGIRNIVLSNpKKRNALSLAMLKSLQSDIlhDADSNDLKVIIISAEGPVFSSGHDLKELTE 114
Cdd:PRK06213  11 DGVATITLDD-GKVNALSPAMIDALNAAL--DQAEDDRAVVVITGQPGIFSGGFDLKVMTS 68
PRK07260 PRK07260
enoyl-CoA hydratase; Provisional
 54-112 9.34e-04

enoyl-CoA hydratase; Provisional


Pssm-ID: 180910 [Multi-domain]  Cd Length: 255  Bit Score: 39.34  E-value: 9.34e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 767960566  54 DGIRNIVLSNPKKRNALSLAMLKSLQSDILHDADSNDLKVIIISAEGPVFSSGHDLKEL 112
Cdd:PRK07260  10 DDLATLTLNRPEVSNGFNIPMCQEILEALRLAEEDPSVRFLLINANGKVFSVGGDLVEM 68
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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