myotubularin-related protein 13 isoform X3 [Homo sapiens]
Protein Classification
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||
| SBF2 | pfam12335 | Myotubularin protein; This domain family is found in eukaryotes, and is approximately 220 ... |
530-754 | 8.26e-148 | ||||
Myotubularin protein; This domain family is found in eukaryotes, and is approximately 220 amino acids in length. The family is found in association with pfam02141, pfam03456, pfam03455. This family is the middle region of SBF2, a member of the myotubularin family. Myotubularin-related proteins have been suggested to work in phosphoinositide-mediated signalling events that may also convey control of myelination. Mutations of SBF2 are implicated in Charcot-Marie-Tooth disease. : Pssm-ID: 463536 Cd Length: 227 Bit Score: 442.52 E-value: 8.26e-148
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| DENN | pfam02141 | DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ... |
116-298 | 3.48e-67 | ||||
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways. : Pssm-ID: 460461 Cd Length: 186 Bit Score: 223.99 E-value: 3.48e-67
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| PH-like super family | cl17171 | Pleckstrin homology-like domain; The PH-like family includes the PH domain, both the Shc-like ... |
882-1000 | 1.87e-57 | ||||
Pleckstrin homology-like domain; The PH-like family includes the PH domain, both the Shc-like and IRS-like PTB domains, the ran-binding domain, the EVH1 domain, a domain in neurobeachin and the third domain of FERM. All of these domains have a PH fold, but lack significant sequence similarity. They are generally involved in targeting to protein to the appropriate cellular location or interacting with a binding partner. This domain family possesses multiple functions including the ability to bind inositol phosphates and to other proteins. The actual alignment was detected with superfamily member cd13339: Pssm-ID: 473070 Cd Length: 119 Bit Score: 193.65 E-value: 1.87e-57
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| uDENN | smart00800 | Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ... |
1-86 | 7.81e-31 | ||||
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity. : Pssm-ID: 214824 Cd Length: 89 Bit Score: 116.67 E-value: 7.81e-31
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| dDENN | smart00801 | Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ... |
352-420 | 5.61e-19 | ||||
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity. : Pssm-ID: 129037 Cd Length: 69 Bit Score: 81.95 E-value: 5.61e-19
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| Name | Accession | Description | Interval | E-value | ||||
| SBF2 | pfam12335 | Myotubularin protein; This domain family is found in eukaryotes, and is approximately 220 ... |
530-754 | 8.26e-148 | ||||
Myotubularin protein; This domain family is found in eukaryotes, and is approximately 220 amino acids in length. The family is found in association with pfam02141, pfam03456, pfam03455. This family is the middle region of SBF2, a member of the myotubularin family. Myotubularin-related proteins have been suggested to work in phosphoinositide-mediated signalling events that may also convey control of myelination. Mutations of SBF2 are implicated in Charcot-Marie-Tooth disease. Pssm-ID: 463536 Cd Length: 227 Bit Score: 442.52 E-value: 8.26e-148
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| DENN | pfam02141 | DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ... |
116-298 | 3.48e-67 | ||||
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways. Pssm-ID: 460461 Cd Length: 186 Bit Score: 223.99 E-value: 3.48e-67
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| DENN | smart00799 | Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ... |
117-298 | 3.90e-64 | ||||
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity. Pssm-ID: 214823 Cd Length: 183 Bit Score: 215.14 E-value: 3.90e-64
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| PH-GRAM_MTMR13 | cd13339 | Myotubularian (MTM) related 13 protein Pleckstrin Homology-Glucosyltransferases, Rab-like ... |
882-1000 | 1.87e-57 | ||||
Myotubularian (MTM) related 13 protein Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain; MTMR13 (also called SBF2/SET binding factor 2) is a catalytically inactive phosphatase that plays a role as an adapter for the phosphatase myotubularin to regulate myotubularintracellular location. It contains a Leu residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase. MTMR13 has high sequence similarity to MTMR5 and has recently been shown to be a second gene mutated in type 4B Charcot-Marie-Tooth syndrome. Both MTMR5 and MTMR13 contain an N-terminal DENN domain, a PH-GRAM domain, an inactive PTP domain, a SET interaction domain, a coiled-coil domain, and a C-terminal PH domain. Myotubularin-related proteins are a subfamily of protein tyrosine phosphatases (PTPs) that dephosphorylate D3-phosphorylated inositol lipids. Mutations in this family cause the human neuromuscular disorders myotubular myopathy and type 4B Charcot-Marie-Tooth syndrome. 6 of the 13 MTMRs (MTMRs 5, 9-13) contain naturally occurring substitutions of residues required for catalysis by PTP family enzymes. Although these proteins are predicted to be enzymatically inactive, they are thought to function as antagonists of endogenous phosphatase activity or interaction modules. Most MTMRs contain a N-terminal PH-GRAM domain, a Rac-induced recruitment domain (RID) domain, a PTP domain (which may be active or inactive), a SET-interaction domain, and a C-terminal coiled-coil region. In addition some members contain DENN domain N-terminal to the PH-GRAM domain and FYVE, PDZ, and PH domains C-terminal to the coiled-coil region. The GRAM domain, found in myotubularins, glucosyltransferases, and other putative membrane-associated proteins, is part of a larger motif with a pleckstrin homology (PH) domain fold. The PH domain family possesses multiple functions including the ability to bind phosphoinositides via its beta1/beta2, beta3/beta4, and beta6/beta7 connecting loops and to other proteins. However, no phosphoinositide binding sites have been found for the MTMRs to date. Pssm-ID: 275416 Cd Length: 119 Bit Score: 193.65 E-value: 1.87e-57
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| uDENN | smart00800 | Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ... |
1-86 | 7.81e-31 | ||||
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity. Pssm-ID: 214824 Cd Length: 89 Bit Score: 116.67 E-value: 7.81e-31
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| uDENN | pfam03456 | uDENN domain; This region is always found associated with pfam02141. It is predicted to form ... |
25-84 | 2.03e-23 | ||||
uDENN domain; This region is always found associated with pfam02141. It is predicted to form an all beta domain. Pssm-ID: 460926 Cd Length: 59 Bit Score: 94.21 E-value: 2.03e-23
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| dDENN | smart00801 | Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ... |
352-420 | 5.61e-19 | ||||
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity. Pssm-ID: 129037 Cd Length: 69 Bit Score: 81.95 E-value: 5.61e-19
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| GRAM | smart00568 | domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins; |
879-957 | 4.08e-05 | ||||
domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins; Pssm-ID: 214725 [Multi-domain] Cd Length: 60 Bit Score: 42.20 E-value: 4.08e-05
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| dDENN | pfam03455 | dDENN domain; This region is always found associated with pfam02141. It is predicted to form a ... |
387-433 | 5.32e-05 | ||||
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a globular domain. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family. This N-terminal region of DENN folds into a longin module, consisting of a central antiparallel beta-sheet layered between helix H1 and helices H2 and H3 (strands S1-S5). Rab35 interacts with dDENN via residues in helix 1 and in the loop S3-S4. Pssm-ID: 460925 Cd Length: 48 Bit Score: 41.80 E-value: 5.32e-05
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| GRAM | pfam02893 | GRAM domain; The GRAM domain is found in in glucosyltransferases, myotubularins and other ... |
914-1006 | 5.10e-04 | ||||
GRAM domain; The GRAM domain is found in in glucosyltransferases, myotubularins and other putative membrane-associated proteins. Note the alignment is lacking the last two beta strands and alpha helix. Pssm-ID: 397160 Cd Length: 112 Bit Score: 40.81 E-value: 5.10e-04
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| Name | Accession | Description | Interval | E-value | ||||
| SBF2 | pfam12335 | Myotubularin protein; This domain family is found in eukaryotes, and is approximately 220 ... |
530-754 | 8.26e-148 | ||||
Myotubularin protein; This domain family is found in eukaryotes, and is approximately 220 amino acids in length. The family is found in association with pfam02141, pfam03456, pfam03455. This family is the middle region of SBF2, a member of the myotubularin family. Myotubularin-related proteins have been suggested to work in phosphoinositide-mediated signalling events that may also convey control of myelination. Mutations of SBF2 are implicated in Charcot-Marie-Tooth disease. Pssm-ID: 463536 Cd Length: 227 Bit Score: 442.52 E-value: 8.26e-148
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| DENN | pfam02141 | DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ... |
116-298 | 3.48e-67 | ||||
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways. Pssm-ID: 460461 Cd Length: 186 Bit Score: 223.99 E-value: 3.48e-67
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| DENN | smart00799 | Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ... |
117-298 | 3.90e-64 | ||||
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity. Pssm-ID: 214823 Cd Length: 183 Bit Score: 215.14 E-value: 3.90e-64
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| PH-GRAM_MTMR13 | cd13339 | Myotubularian (MTM) related 13 protein Pleckstrin Homology-Glucosyltransferases, Rab-like ... |
882-1000 | 1.87e-57 | ||||
Myotubularian (MTM) related 13 protein Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain; MTMR13 (also called SBF2/SET binding factor 2) is a catalytically inactive phosphatase that plays a role as an adapter for the phosphatase myotubularin to regulate myotubularintracellular location. It contains a Leu residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase. MTMR13 has high sequence similarity to MTMR5 and has recently been shown to be a second gene mutated in type 4B Charcot-Marie-Tooth syndrome. Both MTMR5 and MTMR13 contain an N-terminal DENN domain, a PH-GRAM domain, an inactive PTP domain, a SET interaction domain, a coiled-coil domain, and a C-terminal PH domain. Myotubularin-related proteins are a subfamily of protein tyrosine phosphatases (PTPs) that dephosphorylate D3-phosphorylated inositol lipids. Mutations in this family cause the human neuromuscular disorders myotubular myopathy and type 4B Charcot-Marie-Tooth syndrome. 6 of the 13 MTMRs (MTMRs 5, 9-13) contain naturally occurring substitutions of residues required for catalysis by PTP family enzymes. Although these proteins are predicted to be enzymatically inactive, they are thought to function as antagonists of endogenous phosphatase activity or interaction modules. Most MTMRs contain a N-terminal PH-GRAM domain, a Rac-induced recruitment domain (RID) domain, a PTP domain (which may be active or inactive), a SET-interaction domain, and a C-terminal coiled-coil region. In addition some members contain DENN domain N-terminal to the PH-GRAM domain and FYVE, PDZ, and PH domains C-terminal to the coiled-coil region. The GRAM domain, found in myotubularins, glucosyltransferases, and other putative membrane-associated proteins, is part of a larger motif with a pleckstrin homology (PH) domain fold. The PH domain family possesses multiple functions including the ability to bind phosphoinositides via its beta1/beta2, beta3/beta4, and beta6/beta7 connecting loops and to other proteins. However, no phosphoinositide binding sites have been found for the MTMRs to date. Pssm-ID: 275416 Cd Length: 119 Bit Score: 193.65 E-value: 1.87e-57
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| PH-GRAM_MTMR5_MTMR13 | cd13208 | Myotubularian (MTM) related 5 and 13 proteins (MTMR5 and MTMR13) Pleckstrin ... |
882-1000 | 1.09e-48 | ||||
Myotubularian (MTM) related 5 and 13 proteins (MTMR5 and MTMR13) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain; MTMR5 is a catalytically inactive phosphatase that plays a role as an adapter for the phosphatase myotubularin to regulate myotubularintracellular location. It lacks several amino acids in the dsPTPase catalytic pocket which renders it catalytically inactive as a phosphatase. MTMR5 is the most well-studied inactive member of this family and has been implicated in cellular growth control and oncogenic transformation. MTMR13 is a catalytically inactive phosphatase that plays a role as an adapter for the phosphatase myotubularin to regulate myotubularintracellular location. It contains a Leu residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase. MTMR13 has high sequence similarity to MTMR5 and has recently been shown to be a second gene mutated in type 4B Charcot-Marie-Tooth syndrome. Both MTMR5 and MTMR13 contain an N-terminal DENN domain, a PH-GRAM domain, an inactive PTP domain, a SET interaction domain, a coiled-coil domain, and a C-terminal PH domain. Myotubularin-related proteins are a subfamily of protein tyrosine phosphatases (PTPs) that dephosphorylate D3-phosphorylated inositol lipids. Mutations in this family cause the human neuromuscular disorders myotubular myopathy and type 4B Charcot-Marie-Tooth syndrome. 6 of the 13 MTMRs (MTMRs 5, 9-13) contain naturally occurring substitutions of residues required for catalysis by PTP family enzymes. Although these proteins are predicted to be enzymatically inactive, they are thought to function as antagonists of endogenous phosphatase activity or interaction modules. Most MTMRs contain a N-terminal PH-GRAM domain, a Rac-induced recruitment domain (RID) domain, a PTP domain (which may be active or inactive), a SET-interaction domain, and a C-terminal coiled-coil region. In addition some members contain DENN domain N-terminal to the PH-GRAM domain and FYVE, PDZ, and PH domains C-terminal to the coiled-coil region. The GRAM domain, found in myotubularins, glucosyltransferases, and other putative membrane-associated proteins, is part of a larger motif with a pleckstrin homology (PH) domain fold. The PH domain family possesses multiple functions including the ability to bind phosphoinositides via its beta1/beta2, beta3/beta4, and beta6/beta7 connecting loops and to other proteins. However, no phosphoinositide binding sites have been found for the MTMRs to date. Although the majority of the sequences are MTMR 5 and 13, this cd also contains MTM5 nematode sequences. Pssm-ID: 275396 Cd Length: 120 Bit Score: 168.69 E-value: 1.09e-48
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| PH-GRAM_MTMR5 | cd13340 | Myotubularian (MTM) related 5 protein (MTMR5) Pleckstrin Homology-Glucosyltransferases, ... |
882-1000 | 1.71e-42 | ||||
Myotubularian (MTM) related 5 protein (MTMR5) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain; MTMR5 (also called SBF1/SET binding factor 1) is a catalytically inactive phosphatase that plays a role as an adapter for the phosphatase myotubularin to regulate myotubularintracellular location. It lacks several amino acids in the dsPTPase catalytic pocket which renders it catalytically inactive as a phosphatase. MTMR5 is the most well-studied inactive member of this family and has been implicated in cellular growth control and oncogenic transformation. MTMR5 and MTMR13 contain an N-terminal DENN domain, a PH-GRAM domain, an inactive PTP domain, a SET interaction domain, a coiled-coil domain, and a C-terminal PH domain. Myotubularin-related proteins are a subfamily of protein tyrosine phosphatases (PTPs) that dephosphorylate D3-phosphorylated inositol lipids. Mutations in this family cause the human neuromuscular disorders myotubular myopathy and type 4B Charcot-Marie-Tooth syndrome. 6 of the 13 MTMRs (MTMRs 5, 9-13) contain naturally occurring substitutions of residues required for catalysis by PTP family enzymes. Although these proteins are predicted to be enzymatically inactive, they are thought to function as antagonists of endogenous phosphatase activity or interaction modules. Most MTMRs contain a N-terminal PH-GRAM domain, a Rac-induced recruitment domain (RID) domain, a PTP domain (which may be active or inactive), a SET-interaction domain, and a C-terminal coiled-coil region. In addition some members contain DENN domain N-terminal to the PH-GRAM domain and FYVE, PDZ, and PH domains C-terminal to the coiled-coil region. The GRAM domain, found in myotubularins, glucosyltransferases, and other putative membrane-associated proteins, is part of a larger motif with a pleckstrin homology (PH) domain fold. The PH domain family possesses multiple functions including the ability to bind phosphoinositides via its beta1/beta2, beta3/beta4, and beta6/beta7 connecting loops and to other proteins. However, no phosphoinositide binding sites have been found for the MTMRs to date. Pssm-ID: 275417 Cd Length: 119 Bit Score: 150.78 E-value: 1.71e-42
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| uDENN | smart00800 | Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ... |
1-86 | 7.81e-31 | ||||
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity. Pssm-ID: 214824 Cd Length: 89 Bit Score: 116.67 E-value: 7.81e-31
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| uDENN | pfam03456 | uDENN domain; This region is always found associated with pfam02141. It is predicted to form ... |
25-84 | 2.03e-23 | ||||
uDENN domain; This region is always found associated with pfam02141. It is predicted to form an all beta domain. Pssm-ID: 460926 Cd Length: 59 Bit Score: 94.21 E-value: 2.03e-23
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| dDENN | smart00801 | Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ... |
352-420 | 5.61e-19 | ||||
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity. Pssm-ID: 129037 Cd Length: 69 Bit Score: 81.95 E-value: 5.61e-19
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| PH-GRAM | cd10570 | Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins ... |
915-1000 | 1.44e-05 | ||||
Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain; Myotubularin-related proteins are a subfamily of protein tyrosine phosphatases (PTPs) that dephosphorylate D3-phosphorylated inositol lipids. Mutations in this family cause the human neuromuscular disorders myotubular myopathy and type 4B Charcot-Marie-Tooth syndrome. 6 of the 13 MTMRs (MTMRs 5, 9-13) contain naturally occurring substitutions of residues required for catalysis by PTP family enzymes. Although these proteins are predicted to be enzymatically inactive, they are thought to function as antagonists of endogenous phosphatase activity or interaction modules. Most MTMRs contain a N-terminal PH-GRAM domain, a Rac-induced recruitment domain (RID) domain, a PTP domain (which may be active or inactive), a SET-interaction domain, and a C-terminal coiled-coil region. In addition some members contain DENN domain N-terminal to the PH-GRAM domain and FYVE, PDZ, and PH domains C-terminal to the coiled-coil region. The GRAM domain, found in myotubularins, glucosyltransferases, and other putative membrane-associated proteins, is part of a larger motif with a pleckstrin homology (PH) domain fold. Pssm-ID: 275393 Cd Length: 94 Bit Score: 44.68 E-value: 1.44e-05
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| GRAM | smart00568 | domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins; |
879-957 | 4.08e-05 | ||||
domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins; Pssm-ID: 214725 [Multi-domain] Cd Length: 60 Bit Score: 42.20 E-value: 4.08e-05
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| dDENN | pfam03455 | dDENN domain; This region is always found associated with pfam02141. It is predicted to form a ... |
387-433 | 5.32e-05 | ||||
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a globular domain. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family. This N-terminal region of DENN folds into a longin module, consisting of a central antiparallel beta-sheet layered between helix H1 and helices H2 and H3 (strands S1-S5). Rab35 interacts with dDENN via residues in helix 1 and in the loop S3-S4. Pssm-ID: 460925 Cd Length: 48 Bit Score: 41.80 E-value: 5.32e-05
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| SPA | pfam08616 | Stabilization of polarity axis; Swiss:Q99222 has been shown to interact with the outer plaque ... |
208-302 | 3.25e-04 | ||||
Stabilization of polarity axis; Swiss:Q99222 has been shown to interact with the outer plaque of the spindle pole body. In Aspergillus nidulans the protein member is necessary for stabilization of the polarity axes during septation. and in S. cerevisiae it functions as a polarization-specific docking factor. Pssm-ID: 400783 Cd Length: 113 Bit Score: 41.51 E-value: 3.25e-04
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| GRAM | pfam02893 | GRAM domain; The GRAM domain is found in in glucosyltransferases, myotubularins and other ... |
914-1006 | 5.10e-04 | ||||
GRAM domain; The GRAM domain is found in in glucosyltransferases, myotubularins and other putative membrane-associated proteins. Note the alignment is lacking the last two beta strands and alpha helix. Pssm-ID: 397160 Cd Length: 112 Bit Score: 40.81 E-value: 5.10e-04
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