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Conserved domains on  [gi|767984567|ref|XP_011520034|]
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dipeptidyl peptidase 8 isoform X5 [Homo sapiens]

Protein Classification

S9 family peptidase( domain architecture ID 18341295)

peptidase S9 family protein, an oligopeptidase which may cleave the prolyl bond of short peptides, similar to oligopeptidase B, which cleaves on the C-terminal side of lysyl and argininyl residues

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Dpp_8_9_N pfam19520
Dipeptidyl peptidase 8 and 9 N-terminal; Dipeptidyl peptidase (DPP) family members 8 and 9 are ...
 8-162 9.28e-113

Dipeptidyl peptidase 8 and 9 N-terminal; Dipeptidyl peptidase (DPP) family members 8 and 9 are similar to DPP4, consisting of one N-terminal beta-propeller and a C-terminal alpha/beta hydrolase domain, which form a functional homodimer. This entry represents the N-terminal beta-propeller of DPP8 and 9 which consists of eight blades and enlaces a central round pore. It provides the key arginine residue fundamental for substrate fixation which is located in the R-segment, at the interconnecting loop between blades 1 and 2. Ligand binding to DPP8/9 induces a rearrangement at the active site through a disorder-order transition in a loop segment which includes the key arginine residue and partially folds in an alpha-helix (R-helix). DPP8 and DPP9 play a role in the immune system and in preadipocyte differentiation. DPP9 is also essential for neonatal survival and plays a role in antigen maturation, cell migration, and cell adhesion.


:

Pssm-ID: 466112  Cd Length: 155  Bit Score: 340.01  E-value: 9.28e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984567    8 MKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVK 87
Cdd:pfam19520   1 MSVPSTACNMAAAMETEQLGLEIFETAECEENVESEDSPKLEPFYVERYSWSQLKKLLTDTRKYHGYMMAKAPHDFMFVK 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767984567   88 RNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIG 162
Cdd:pfam19520  81 KNDPEGPHSDRVYYLAMSGENRENTLFYSEIPKTINKAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIG 155
DPPIV_N pfam00930
Dipeptidyl peptidase IV (DPP IV) N-terminal region; This family is an alignment of the region ...
 175-595 2.71e-92

Dipeptidyl peptidase IV (DPP IV) N-terminal region; This family is an alignment of the region to the N-terminal side of the active site. The Prosite motif does not correspond to this Pfam entry.


:

Pssm-ID: 395744 [Multi-domain]  Cd Length: 352  Bit Score: 294.23  E-value: 2.71e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984567  175 SGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPN--IRMDPKLCPaDPDWIAFIHSNDIWISNIVTREERRLTYv 252
Cdd:pfam00930   3 DGKYLLLATNYTKNWRHSYTADYYIYDLETNRVEPLPPGegKIQDAKWSP-DGDRLAFVRDNNLYVRELATGKEIQITS- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984567  253 hnelanMEEDARSAGVATFVLQEE-FDRYSGYWWCPKAEttpsggkilRILYEENDESEVEIIHVTSPMLETR--RADSF 329
Cdd:pfam00930  81 ------DGSDGIFNGVADWVYEEEvLGSNSAVWWSPDGS---------RLAFLRFDESEVPIITLPYYTDEGPgpEVREI 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984567  330 RYPKTGTANPKVTFKMSEImidAEGRIIdvidkeLIQPFEILFEGVEYIARAGWTPEGKyAWSILLDRSQTRLQIVLISP 409
Cdd:pfam00930 146 KYPKAGAPNPTVELFVYDL---ASGKTV------EVVPPDDLSDADYYITRVKWVPDGK-LLVQWLNRDQNRLKVVLCDA 215

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984567  410 ElfipveddvmerqrliesvpdSVTPLIIYEETTDIWINIHDIFHVFPQSHEEeieFIFASEcKTGFRHLYKITSIlkes 489
Cdd:pfam00930 216 E---------------------TGRTVVILEETSDGWVELHQDPHFIKRDGSG---FLWISE-RDGYNHLYLYDLD---- 266

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984567  490 kykrssGGLPapsdfkcpikeeIAITSGEWEVlgrhGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDR 569
Cdd:pfam00930 267 ------GKSP------------IQLTSGNWEV----TSILGVDETRDLVYFTATEDSPTERHLYSVSLDSGGEPTCLTDD 324

                         410       420
                  ....*....|....*....|....*...
gi 767984567  570 GYSH--SCCISQHCDFFISKYSNQKNPH 595
Cdd:pfam00930 325 SGDHdySASFSPNGSYYVLTYSGPDTPP 352
Peptidase_S9 super family cl47529
Prolyl oligopeptidase family;
687-806 1.32e-45

Prolyl oligopeptidase family;


The actual alignment was detected with superfamily member pfam00326:

Pssm-ID: 459761 [Multi-domain]  Cd Length: 213  Bit Score: 162.78  E-value: 1.32e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984567  687 FRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYdFIDLDRVGIHGWSYGGYLSLMALM 766
Cdd:pfam00326   5 WNAQLLADRGYVVAIANGRGSGGYGEAFHDAGKGDLGQNEFDDFIAAAEYLIEQG-YTDPDRLAIWGGSYGGYLTGAALN 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 767984567  767 QRSDIFRVAIAGAPVTLWIFYDTG----YTERYMGH--PDQNEQGY 806
Cdd:pfam00326  84 QRPDLFKAAVAHVPVVDWLAYMSDtslpFTERYMEWgnPWDNEEGY 129
 
Name Accession Description Interval E-value
Dpp_8_9_N pfam19520
Dipeptidyl peptidase 8 and 9 N-terminal; Dipeptidyl peptidase (DPP) family members 8 and 9 are ...
 8-162 9.28e-113

Dipeptidyl peptidase 8 and 9 N-terminal; Dipeptidyl peptidase (DPP) family members 8 and 9 are similar to DPP4, consisting of one N-terminal beta-propeller and a C-terminal alpha/beta hydrolase domain, which form a functional homodimer. This entry represents the N-terminal beta-propeller of DPP8 and 9 which consists of eight blades and enlaces a central round pore. It provides the key arginine residue fundamental for substrate fixation which is located in the R-segment, at the interconnecting loop between blades 1 and 2. Ligand binding to DPP8/9 induces a rearrangement at the active site through a disorder-order transition in a loop segment which includes the key arginine residue and partially folds in an alpha-helix (R-helix). DPP8 and DPP9 play a role in the immune system and in preadipocyte differentiation. DPP9 is also essential for neonatal survival and plays a role in antigen maturation, cell migration, and cell adhesion.


Pssm-ID: 466112  Cd Length: 155  Bit Score: 340.01  E-value: 9.28e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984567    8 MKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVK 87
Cdd:pfam19520   1 MSVPSTACNMAAAMETEQLGLEIFETAECEENVESEDSPKLEPFYVERYSWSQLKKLLTDTRKYHGYMMAKAPHDFMFVK 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767984567   88 RNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIG 162
Cdd:pfam19520  81 KNDPEGPHSDRVYYLAMSGENRENTLFYSEIPKTINKAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIG 155
DPPIV_N pfam00930
Dipeptidyl peptidase IV (DPP IV) N-terminal region; This family is an alignment of the region ...
 175-595 2.71e-92

Dipeptidyl peptidase IV (DPP IV) N-terminal region; This family is an alignment of the region to the N-terminal side of the active site. The Prosite motif does not correspond to this Pfam entry.


Pssm-ID: 395744 [Multi-domain]  Cd Length: 352  Bit Score: 294.23  E-value: 2.71e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984567  175 SGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPN--IRMDPKLCPaDPDWIAFIHSNDIWISNIVTREERRLTYv 252
Cdd:pfam00930   3 DGKYLLLATNYTKNWRHSYTADYYIYDLETNRVEPLPPGegKIQDAKWSP-DGDRLAFVRDNNLYVRELATGKEIQITS- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984567  253 hnelanMEEDARSAGVATFVLQEE-FDRYSGYWWCPKAEttpsggkilRILYEENDESEVEIIHVTSPMLETR--RADSF 329
Cdd:pfam00930  81 ------DGSDGIFNGVADWVYEEEvLGSNSAVWWSPDGS---------RLAFLRFDESEVPIITLPYYTDEGPgpEVREI 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984567  330 RYPKTGTANPKVTFKMSEImidAEGRIIdvidkeLIQPFEILFEGVEYIARAGWTPEGKyAWSILLDRSQTRLQIVLISP 409
Cdd:pfam00930 146 KYPKAGAPNPTVELFVYDL---ASGKTV------EVVPPDDLSDADYYITRVKWVPDGK-LLVQWLNRDQNRLKVVLCDA 215

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984567  410 ElfipveddvmerqrliesvpdSVTPLIIYEETTDIWINIHDIFHVFPQSHEEeieFIFASEcKTGFRHLYKITSIlkes 489
Cdd:pfam00930 216 E---------------------TGRTVVILEETSDGWVELHQDPHFIKRDGSG---FLWISE-RDGYNHLYLYDLD---- 266

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984567  490 kykrssGGLPapsdfkcpikeeIAITSGEWEVlgrhGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDR 569
Cdd:pfam00930 267 ------GKSP------------IQLTSGNWEV----TSILGVDETRDLVYFTATEDSPTERHLYSVSLDSGGEPTCLTDD 324

                         410       420
                  ....*....|....*....|....*...
gi 767984567  570 GYSH--SCCISQHCDFFISKYSNQKNPH 595
Cdd:pfam00930 325 SGDHdySASFSPNGSYYVLTYSGPDTPP 352
Peptidase_S9 pfam00326
Prolyl oligopeptidase family;
687-806 1.32e-45

Prolyl oligopeptidase family;


Pssm-ID: 459761 [Multi-domain]  Cd Length: 213  Bit Score: 162.78  E-value: 1.32e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984567  687 FRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYdFIDLDRVGIHGWSYGGYLSLMALM 766
Cdd:pfam00326   5 WNAQLLADRGYVVAIANGRGSGGYGEAFHDAGKGDLGQNEFDDFIAAAEYLIEQG-YTDPDRLAIWGGSYGGYLTGAALN 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 767984567  767 QRSDIFRVAIAGAPVTLWIFYDTG----YTERYMGH--PDQNEQGY 806
Cdd:pfam00326  84 QRPDLFKAAVAHVPVVDWLAYMSDtslpFTERYMEWgnPWDNEEGY 129
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
637-817 5.73e-41

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 150.17  E-value: 5.73e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984567 637 SFESTTGFTLYGMLYKPHDlqpGKKYPTVLFIYGGPQVQLVNNRFkgvkyfRLNTLASLGYVVVVIDNRGschRGLKfEG 716
Cdd:COG1506    1 TFKSADGTTLPGWLYLPAD---GKKYPVVVYVHGGPGSRDDSFLP------LAQALASRGYAVLAPDYRG---YGES-AG 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984567 717 afkyKMGQIEIDDQVEGLQYLASRyDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTG---YTE 793
Cdd:COG1506   68 ----DWGGDEVDDVLAAIDYLAAR-PYVDPDRIGIYGHSYGGYMALLAAARHPDRFKAAVALAGVSDLRSYYGTtreYTE 142

                        170       180
                 ....*....|....*....|....
gi 767984567 794 RYMGHPDQNEQGYYLGSVAMQAEK 817
Cdd:COG1506  143 RLMGGPWEDPEAYAARSPLAYADK 166
 
Name Accession Description Interval E-value
Dpp_8_9_N pfam19520
Dipeptidyl peptidase 8 and 9 N-terminal; Dipeptidyl peptidase (DPP) family members 8 and 9 are ...
 8-162 9.28e-113

Dipeptidyl peptidase 8 and 9 N-terminal; Dipeptidyl peptidase (DPP) family members 8 and 9 are similar to DPP4, consisting of one N-terminal beta-propeller and a C-terminal alpha/beta hydrolase domain, which form a functional homodimer. This entry represents the N-terminal beta-propeller of DPP8 and 9 which consists of eight blades and enlaces a central round pore. It provides the key arginine residue fundamental for substrate fixation which is located in the R-segment, at the interconnecting loop between blades 1 and 2. Ligand binding to DPP8/9 induces a rearrangement at the active site through a disorder-order transition in a loop segment which includes the key arginine residue and partially folds in an alpha-helix (R-helix). DPP8 and DPP9 play a role in the immune system and in preadipocyte differentiation. DPP9 is also essential for neonatal survival and plays a role in antigen maturation, cell migration, and cell adhesion.


Pssm-ID: 466112  Cd Length: 155  Bit Score: 340.01  E-value: 9.28e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984567    8 MKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVK 87
Cdd:pfam19520   1 MSVPSTACNMAAAMETEQLGLEIFETAECEENVESEDSPKLEPFYVERYSWSQLKKLLTDTRKYHGYMMAKAPHDFMFVK 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767984567   88 RNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIG 162
Cdd:pfam19520  81 KNDPEGPHSDRVYYLAMSGENRENTLFYSEIPKTINKAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIG 155
DPPIV_N pfam00930
Dipeptidyl peptidase IV (DPP IV) N-terminal region; This family is an alignment of the region ...
 175-595 2.71e-92

Dipeptidyl peptidase IV (DPP IV) N-terminal region; This family is an alignment of the region to the N-terminal side of the active site. The Prosite motif does not correspond to this Pfam entry.


Pssm-ID: 395744 [Multi-domain]  Cd Length: 352  Bit Score: 294.23  E-value: 2.71e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984567  175 SGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPN--IRMDPKLCPaDPDWIAFIHSNDIWISNIVTREERRLTYv 252
Cdd:pfam00930   3 DGKYLLLATNYTKNWRHSYTADYYIYDLETNRVEPLPPGegKIQDAKWSP-DGDRLAFVRDNNLYVRELATGKEIQITS- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984567  253 hnelanMEEDARSAGVATFVLQEE-FDRYSGYWWCPKAEttpsggkilRILYEENDESEVEIIHVTSPMLETR--RADSF 329
Cdd:pfam00930  81 ------DGSDGIFNGVADWVYEEEvLGSNSAVWWSPDGS---------RLAFLRFDESEVPIITLPYYTDEGPgpEVREI 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984567  330 RYPKTGTANPKVTFKMSEImidAEGRIIdvidkeLIQPFEILFEGVEYIARAGWTPEGKyAWSILLDRSQTRLQIVLISP 409
Cdd:pfam00930 146 KYPKAGAPNPTVELFVYDL---ASGKTV------EVVPPDDLSDADYYITRVKWVPDGK-LLVQWLNRDQNRLKVVLCDA 215

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984567  410 ElfipveddvmerqrliesvpdSVTPLIIYEETTDIWINIHDIFHVFPQSHEEeieFIFASEcKTGFRHLYKITSIlkes 489
Cdd:pfam00930 216 E---------------------TGRTVVILEETSDGWVELHQDPHFIKRDGSG---FLWISE-RDGYNHLYLYDLD---- 266

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984567  490 kykrssGGLPapsdfkcpikeeIAITSGEWEVlgrhGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDR 569
Cdd:pfam00930 267 ------GKSP------------IQLTSGNWEV----TSILGVDETRDLVYFTATEDSPTERHLYSVSLDSGGEPTCLTDD 324

                         410       420
                  ....*....|....*....|....*...
gi 767984567  570 GYSH--SCCISQHCDFFISKYSNQKNPH 595
Cdd:pfam00930 325 SGDHdySASFSPNGSYYVLTYSGPDTPP 352
Peptidase_S9 pfam00326
Prolyl oligopeptidase family;
687-806 1.32e-45

Prolyl oligopeptidase family;


Pssm-ID: 459761 [Multi-domain]  Cd Length: 213  Bit Score: 162.78  E-value: 1.32e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984567  687 FRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYdFIDLDRVGIHGWSYGGYLSLMALM 766
Cdd:pfam00326   5 WNAQLLADRGYVVAIANGRGSGGYGEAFHDAGKGDLGQNEFDDFIAAAEYLIEQG-YTDPDRLAIWGGSYGGYLTGAALN 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 767984567  767 QRSDIFRVAIAGAPVTLWIFYDTG----YTERYMGH--PDQNEQGY 806
Cdd:pfam00326  84 QRPDLFKAAVAHVPVVDWLAYMSDtslpFTERYMEWgnPWDNEEGY 129
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
637-817 5.73e-41

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 150.17  E-value: 5.73e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984567 637 SFESTTGFTLYGMLYKPHDlqpGKKYPTVLFIYGGPQVQLVNNRFkgvkyfRLNTLASLGYVVVVIDNRGschRGLKfEG 716
Cdd:COG1506    1 TFKSADGTTLPGWLYLPAD---GKKYPVVVYVHGGPGSRDDSFLP------LAQALASRGYAVLAPDYRG---YGES-AG 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984567 717 afkyKMGQIEIDDQVEGLQYLASRyDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTG---YTE 793
Cdd:COG1506   68 ----DWGGDEVDDVLAAIDYLAAR-PYVDPDRIGIYGHSYGGYMALLAAARHPDRFKAAVALAGVSDLRSYYGTtreYTE 142

                        170       180
                 ....*....|....*....|....
gi 767984567 794 RYMGHPDQNEQGYYLGSVAMQAEK 817
Cdd:COG1506  143 RLMGGPWEDPEAYAARSPLAYADK 166
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 634-771 1.05e-12

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 68.79  E-value: 1.05e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984567 634 EIFSFESTTGFTLYGMLYKPHDlqPGKKYPTVLFIYGgpqvqlvnnrFKGVKYFRL---NTLASLGYVVVVIDNRG---S 707
Cdd:COG1073   11 EDVTFKSRDGIKLAGDLYLPAG--ASKKYPAVVVAHG----------NGGVKEQRAlyaQRLAELGFNVLAFDYRGygeS 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767984567 708 chrglkfEGAFKYkMGQIEIDDQVEGLQYLASRyDFIDLDRVGIHGWSYGGYLSLMALMQRSDI 771
Cdd:COG1073   79 -------EGEPRE-EGSPERRDARAAVDYLRTL-PGVDPERIGLLGISLGGGYALNAAATDPRV 133
DLH COG0412
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
634-782 7.16e-11

Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440181 [Multi-domain]  Cd Length: 226  Bit Score: 63.06  E-value: 7.16e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984567 634 EIFSFESTTGFTLYGMLYKPHDlqpGKKYPTVLFI--YGGpqvqlVNNRFKGVkyfrLNTLASLGYVVVVID--NRGSch 709
Cdd:COG0412    4 ETVTIPTPDGVTLPGYLARPAG---GGPRPGVVVLheIFG-----LNPHIRDV----ARRLAAAGYVVLAPDlyGRGG-- 69

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767984567 710 RGLKFEGAFKYkMGQIEIDDQVE----GLQYLASRyDFIDLDRVGIHGWSYGGYLSLMALMQRSDIfR--VAIAGAPVT 782
Cdd:COG0412   70 PGDDPDEARAL-MGALDPELLAAdlraALDWLKAQ-PEVDAGRVGVVGFCFGGGLALLAAARGPDL-AaaVSFYGGLPA 145
COG4099 COG4099
Predicted peptidase [General function prediction only];
650-786 7.37e-08

Predicted peptidase [General function prediction only];


Pssm-ID: 443275 [Multi-domain]  Cd Length: 235  Bit Score: 54.20  E-value: 7.37e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984567 650 LYKPHDLQPGKKYPTVLFIYGG------PQVQLVNnrfKGVKYFRLNTLASLGYVVVVidnrGSCHRGlkfegafKYKMG 723
Cdd:COG4099   37 LYLPKGYDPGKKYPLVLFLHGAgergtdNEKQLTH---GAPKFINPENQAKFPAIVLA----PQCPED-------DYWSD 102

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767984567 724 QIEIDDQVEGLQYLASRYDfIDLDRVGIHGWSYGGYLSLMALMQRSDIFR--VAIAGAP----------VTLWIF 786
Cdd:COG4099  103 TKALDAVLALLDDLIAEYR-IDPDRIYLTGLSMGGYGTWDLAARYPDLFAaaVPICGGGdpanaanlkkVPVWIF 176
BD-FAE pfam20434
BD-FAE; This family represents a novel bifunctional feruloyl and acetyl xylan esterase (BD-FAE, ...
 650-764 1.56e-06

BD-FAE; This family represents a novel bifunctional feruloyl and acetyl xylan esterase (BD-FAE, previously known as bifunctional carbohydrate esterase (CE)), which is active on complex natural xylans and was identified as the basis of a monophyletic clade gathering all homologs identified in PULs (polysaccharide utilization loci) predicted to act on xylan. It adopts an alpha-beta-hydrolase fold with the catalytic triad Ser-Asp-His. This new family of proteins is a new candidate for biomass processing due to its capacity to remove ferulic acid and acetic acid from natural corn and birchwood xylan substrates.


Pssm-ID: 466583 [Multi-domain]  Cd Length: 215  Bit Score: 49.87  E-value: 1.56e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984567  650 LYKPhdLQPGKKYPTVLFIYGGPQvqlvnnrFKGVKY----FRLNTLASL---GYVVVVIDNRGSCHRglKFEGAfkykm 722
Cdd:pfam20434   3 IYLP--KNAKGPYPVVIWIHGGGW-------NSGDKEadmgFMTNTVKALlkaGYAVASINYRLSTDA--KFPAQ----- 66

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 767984567  723 gqieIDDQVEGLQYL---ASRYDfIDLDRVGIHGWSYGGYLSLMA 764
Cdd:pfam20434  67 ----IQDVKAAIRFLranAAKYG-IDTNKIALMGFSAGGHLALLA 106
COG4188 COG4188
Predicted dienelactone hydrolase [General function prediction only];
692-775 1.50e-05

Predicted dienelactone hydrolase [General function prediction only];


Pssm-ID: 443342 [Multi-domain]  Cd Length: 326  Bit Score: 47.79  E-value: 1.50e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984567 692 LASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEI------D-----DQVEGLQYLASRY-DFIDLDRVGIHGWSYGGY 759
Cdd:COG4188   85 LASHGYVVAAPDHPGSNAADLSAALDGLADALDPEElwerplDlsfvlDQLLALNKSDPPLaGRLDLDRIGVIGHSLGGY 164

                         90
                 ....*....|....*.
gi 767984567 760 LSLMALMQRSDIFRVA 775
Cdd:COG4188  165 TALALAGARLDFAALR 180
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
632-780 2.16e-05

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 46.53  E-value: 2.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984567 632 PPEIFSFESTTGFTLYGMLYKPHDlQPGkkyPTVLFIYGGpqvqlvnnRFKGVKYFRL-NTLASLGYVVVVIDNRG---S 707
Cdd:COG2267    2 TRRLVTLPTRDGLRLRGRRWRPAG-SPR---GTVVLVHGL--------GEHSGRYAELaEALAAAGYAVLAFDLRGhgrS 69

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767984567 708 CHRGLKFEGAFKYkmgqieIDDQVEGLQYLASRYDfidlDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAP 780
Cdd:COG2267   70 DGPRGHVDSFDDY------VDDLRAALDALRARPG----LPVVLLGHSMGGLIALLYAARYPDRVAGLVLLAP 132
Peptidase_S15 pfam02129
X-Pro dipeptidyl-peptidase (S15 family);
650-790 4.14e-05

X-Pro dipeptidyl-peptidase (S15 family);


Pssm-ID: 396621 [Multi-domain]  Cd Length: 264  Bit Score: 46.18  E-value: 4.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984567  650 LYKPhdLQPGKKYPTVLFI--YGGPqvqlvNNRFKGVKYFRLN-TLASLGYVVVVIDNRGSchRGLkfEGAFKYKMGQiE 726
Cdd:pfam02129   9 IYRP--TKTGGPVPALLTRspYGAR-----RDGASDLALAHPEwEFAARGYAVVYQDVRGT--GGS--EGVFTVGGPQ-E 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767984567  727 IDDQVEGLQYLASRYDFIDldRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLW--IFYDTG 790
Cdd:pfam02129  77 AADGKDVIDWLAGQPWCNG--KVGMTGISYLGTTQLAAAATGPPGLKAIAPESGISDLydYYREGG 140
COG2936 COG2936
Predicted acyl esterase [General function prediction only];
645-768 3.05e-04

Predicted acyl esterase [General function prediction only];


Pssm-ID: 442179 [Multi-domain]  Cd Length: 555  Bit Score: 44.15  E-value: 3.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984567 645 TLYGMLYKPHDLQpgKKYPTVLFI--YGgpqvqlVNNRFKGVKYFRLNTLASLGYVVVVIDNRG---SchrglkfEGAFk 719
Cdd:COG2936   24 RLAADIYRPKDAE--GPVPVILERtpYG------KRDGTAGRDLGPHPYFAERGYAVVVQDVRGtggS-------EGEF- 87

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 767984567 720 YKMGQIEIDDQVEGLQYLAsrydfiDLD----RVGIHGWSYGGYLSLMALMQR 768
Cdd:COG2936   88 DPYRVDEQTDGYDTIDWLA------KQPwsngKVGMIGISYGGFTQLAAAADR 134
Aes COG0657
Acetyl esterase/lipase [Lipid transport and metabolism];
650-782 6.61e-04

Acetyl esterase/lipase [Lipid transport and metabolism];


Pssm-ID: 440422 [Multi-domain]  Cd Length: 207  Bit Score: 41.78  E-value: 6.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984567 650 LYKPHDlqPGKKYPTVLFIYGGpqvqlvnnrfkgvkYFRLNTL-----------ASLGYVVVVIDNRgschrgL----KF 714
Cdd:COG0657    3 VYRPAG--AKGPLPVVVYFHGG--------------GWVSGSKdthdplarrlaARAGAAVVSVDYR------LapehPF 60

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767984567 715 EGAfkykmgqieIDDQVEGLQYLASRYDF--IDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGA----PVT 782
Cdd:COG0657   61 PAA---------LEDAYAALRWLRANAAElgIDPDRIAVAGDSAGGHLAAALALRARDRGGPRPAAQvliyPVL 125
YbbA COG2819
Predicted hydrolase of the alpha/beta superfamily [General function prediction only];
736-784 1.87e-03

Predicted hydrolase of the alpha/beta superfamily [General function prediction only];


Pssm-ID: 442067 [Multi-domain]  Cd Length: 250  Bit Score: 40.74  E-value: 1.87e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 767984567 736 YLASRYDfIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPvTLW 784
Cdd:COG2819  120 YIDKRYR-TDPERTGLIGHSLGGLFSLYALLKYPDLFGRYIAISP-SLW 166
Fes COG2382
Enterochelin esterase or related enzyme [Inorganic ion transport and metabolism];
650-777 2.07e-03

Enterochelin esterase or related enzyme [Inorganic ion transport and metabolism];


Pssm-ID: 441948 [Multi-domain]  Cd Length: 314  Bit Score: 40.99  E-value: 2.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984567 650 LYKPHD-LQPGKKYPTVLFIYGGPQVQlvnNRFkgVKYFRLNT-LASL-------GYVVVVIDNRGSCHRGLKFEGAFKY 720
Cdd:COG2382   99 VYLPPGyDNPGKKYPVLYLLDGGGGDE---QDW--FDQGRLPTiLDNLiaagkipPMIVVMPDGGDGGDRGTEGPGNDAF 173

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 767984567 721 kmgQIEIDDQVegLQYLASRYDFI-DLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIA 777
Cdd:COG2382  174 ---ERFLAEEL--IPFVEKNYRVSaDPEHRAIAGLSMGGLAALYAALRHPDLFGYVGS 226
COG2945 COG2945
Alpha/beta superfamily hydrolase [General function prediction only];
691-786 2.46e-03

Alpha/beta superfamily hydrolase [General function prediction only];


Pssm-ID: 442188 [Multi-domain]  Cd Length: 201  Bit Score: 40.15  E-value: 2.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984567 691 TLASLGYVVVVIDNRG---SchrglkfEGAFKYkmGQIEIDDQVEGLQYLASRYdfidLDRVGIHGWSYGGYLSLMALMQ 767
Cdd:COG2945   50 ALVAAGFAVLRFNFRGvgrS-------EGEFDE--GRGELDDAAAALDWLRAQN----PLPLWLAGFSFGAYVALQLAMR 116

                         90
                 ....*....|....*....
gi 767984567 768 RSDIFRVAIAGAPVTLWIF 786
Cdd:COG2945  117 LPEVEGLILVAPPVNRYDF 135
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 663-789 2.72e-03

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 40.18  E-value: 2.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984567  663 PTVLFIYGGPQVqlvnnrfkGVKYFRL-NTLASLGYVVVVIDNRGSCH-RGLKFEGAFkykmgqiEIDDQVEGLQYLASR 740
Cdd:pfam00561   1 PPVLLLHGLPGS--------SDLWRKLaPALARDGFRVIALDLRGFGKsSRPKAQDDY-------RTDDLAEDLEYILEA 65

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 767984567  741 YDfidLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDT 789
Cdd:pfam00561  66 LG---LEKVNLVGHSMGGLIALAYAAKYPDRVKALVLLGALDPPHELDE 111
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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