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Conserved domains on  [gi|767990449|ref|XP_011521596|]
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protein NDRG4 isoform X5 [Homo sapiens]

Protein Classification

NDRG family protein( domain architecture ID 11140417)

N-myc downstream-regulated gene (NDRG) family protein may be involved in cellular differentiation events; similar to Homo sapiens protein NDRG1, which is a stress-responsive protein involved in hormone responses, cell growth, and differentiation; belongs to the alpha/beta hydrolase superfamily

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Ndr pfam03096
Ndr family; This family consists of proteins from different gene families: Ndr1/RTP/Drg1, Ndr2, ...
40-322 2.93e-166

Ndr family; This family consists of proteins from different gene families: Ndr1/RTP/Drg1, Ndr2, and Ndr3. Their similarity was previously noted. The precise molecular and cellular function of members of this family is still unknown. Yet, they are known to be involved in cellular differentiation events. The Ndr1 group was the first to be discovered. Their expression is repressed by the proto-oncogenes N-myc and c-myc, and in line with this observation, Ndr1 protein expression is down-regulated in neoplastic cells, and is reactivated when differentiation is induced by chemicals such as retinoic acid. Ndr2 and Ndr3 expression is not under the control of N-myc or c-myc. Ndr1 expression is also activated by several chemicals: tunicamycin and homocysteine induce Ndr1 in human umbilical endothelial cells; nickel induces Ndr1 in several cell types. Members of this family are found in wide variety of multicellular eukaryotes, including an Ndr1 type protein in Helianthus annuus (sunflower), known as Sf21. Interestingly, the highest scoring matches in the noise are all alpha/beta hydrolases pfam00561, suggesting that this family may have an enzymatic function (Bateman A pers. obs.).


:

Pssm-ID: 397285 [Multi-domain]  Cd Length: 285  Bit Score: 466.44  E-value: 2.93e-166
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767990449   40 EHDIETPYGLLHVVIRGSPKGNRPAILTYHDVGLNHKLCFNTFFNFEDMQEITKHFVVCHVDAPGQQVGASQFPQGYQFP 119
Cdd:pfam03096   1 EHIIETPCGSVHVTVYGDPEGKKPPILTYHDLGLNHKSCFQGLFNSESMQEILENFCIYHVDAPGQEDGAASFPGGYPYP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767990449  120 SMEQLAAMLPSVVQHFGFKYVIGIGVGAGAYVLAKFALIFPDLVEGLVLVNIDPNGKGWIDWAATKLS-------GLTST 192
Cdd:pfam03096  81 SMDDLADMLPVVLDHFRLKSVIGMGVGAGAYILARFALKHPERVEGLVLINPTPKAAGWIEWFYNKLSskllyyyGMTDS 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767990449  193 LPDTVLSHLFSQEELVNNTELVQSYRQQIGNVVNQANLQLFWNMYNSRRDLDINRPGTvpnakTLRCPVMLVVGDNAPAE 272
Cdd:pfam03096 161 AKDYLLAHYFGKEELSNNSDIVQEYRKFLKERLNPKNLQLYLEAYNSRRDLTIERPGL-----ETKCPVLLVVGDNSPHV 235
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 767990449  273 DGVVECNSKLDPTTTTFLKMADSGGLPQVTQPGKLTEAFKYFLQGMGYIA 322
Cdd:pfam03096 236 DAVVECNTKLDPTKTTLLKVADCGGLVQQEQPGKLTESFKLFLQGMGYYP 285
 
Name Accession Description Interval E-value
Ndr pfam03096
Ndr family; This family consists of proteins from different gene families: Ndr1/RTP/Drg1, Ndr2, ...
40-322 2.93e-166

Ndr family; This family consists of proteins from different gene families: Ndr1/RTP/Drg1, Ndr2, and Ndr3. Their similarity was previously noted. The precise molecular and cellular function of members of this family is still unknown. Yet, they are known to be involved in cellular differentiation events. The Ndr1 group was the first to be discovered. Their expression is repressed by the proto-oncogenes N-myc and c-myc, and in line with this observation, Ndr1 protein expression is down-regulated in neoplastic cells, and is reactivated when differentiation is induced by chemicals such as retinoic acid. Ndr2 and Ndr3 expression is not under the control of N-myc or c-myc. Ndr1 expression is also activated by several chemicals: tunicamycin and homocysteine induce Ndr1 in human umbilical endothelial cells; nickel induces Ndr1 in several cell types. Members of this family are found in wide variety of multicellular eukaryotes, including an Ndr1 type protein in Helianthus annuus (sunflower), known as Sf21. Interestingly, the highest scoring matches in the noise are all alpha/beta hydrolases pfam00561, suggesting that this family may have an enzymatic function (Bateman A pers. obs.).


Pssm-ID: 397285 [Multi-domain]  Cd Length: 285  Bit Score: 466.44  E-value: 2.93e-166
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767990449   40 EHDIETPYGLLHVVIRGSPKGNRPAILTYHDVGLNHKLCFNTFFNFEDMQEITKHFVVCHVDAPGQQVGASQFPQGYQFP 119
Cdd:pfam03096   1 EHIIETPCGSVHVTVYGDPEGKKPPILTYHDLGLNHKSCFQGLFNSESMQEILENFCIYHVDAPGQEDGAASFPGGYPYP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767990449  120 SMEQLAAMLPSVVQHFGFKYVIGIGVGAGAYVLAKFALIFPDLVEGLVLVNIDPNGKGWIDWAATKLS-------GLTST 192
Cdd:pfam03096  81 SMDDLADMLPVVLDHFRLKSVIGMGVGAGAYILARFALKHPERVEGLVLINPTPKAAGWIEWFYNKLSskllyyyGMTDS 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767990449  193 LPDTVLSHLFSQEELVNNTELVQSYRQQIGNVVNQANLQLFWNMYNSRRDLDINRPGTvpnakTLRCPVMLVVGDNAPAE 272
Cdd:pfam03096 161 AKDYLLAHYFGKEELSNNSDIVQEYRKFLKERLNPKNLQLYLEAYNSRRDLTIERPGL-----ETKCPVLLVVGDNSPHV 235
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 767990449  273 DGVVECNSKLDPTTTTFLKMADSGGLPQVTQPGKLTEAFKYFLQGMGYIA 322
Cdd:pfam03096 236 DAVVECNTKLDPTKTTLLKVADCGGLVQQEQPGKLTESFKLFLQGMGYYP 285
MhpC COG0596
Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General ...
94-317 1.15e-10

Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only];


Pssm-ID: 223669 [Multi-domain]  Cd Length: 282  Bit Score: 61.57  E-value: 1.15e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767990449  94 HFVVCHVDAPGqqVGASQFPqgyqFPSMEQLAAMLPSVVQHFGFKYVIGIGVGAGAYVLAKFALIFPDLVEGLVLVNIDP 173
Cdd:COG0596   50 RYRVIAPDLRG--HGRSDPA----GYSLSAYADDLAALLDALGLEKVVLVGHSMGGAVALALALRHPDRVRGLVLIGPAP 123
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767990449 174 NGKGWIDWAATKLSGLTS------------------TLPDTVLSHLFSQEELVNNTELVQSYRQQIGNVVNQANLQLFWN 235
Cdd:COG0596  124 PPGLLEAALRQPAGAAPLaaladlllgldaaafaalLAALGLLAALAAAARAGLAEALRAPLLGAAAAAFARAARADLAA 203
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767990449 236 MYNSRRDLDINRPgtvpnAKTLRCPVMLVVGDNAP-AEDGVVECNSKLDPTTTTFLKMADSGGLPQVTQPGKLTEAFKYF 314
Cdd:COG0596  204 ALLALLDRDLRAA-----LARITVPTLIIHGEDDPvVPAELARRLAAALPNDARLVVIPGAGHFPHLEAPEAFAAALLAF 278

                 ...
gi 767990449 315 LQG 317
Cdd:COG0596  279 LER 281
 
Name Accession Description Interval E-value
Ndr pfam03096
Ndr family; This family consists of proteins from different gene families: Ndr1/RTP/Drg1, Ndr2, ...
40-322 2.93e-166

Ndr family; This family consists of proteins from different gene families: Ndr1/RTP/Drg1, Ndr2, and Ndr3. Their similarity was previously noted. The precise molecular and cellular function of members of this family is still unknown. Yet, they are known to be involved in cellular differentiation events. The Ndr1 group was the first to be discovered. Their expression is repressed by the proto-oncogenes N-myc and c-myc, and in line with this observation, Ndr1 protein expression is down-regulated in neoplastic cells, and is reactivated when differentiation is induced by chemicals such as retinoic acid. Ndr2 and Ndr3 expression is not under the control of N-myc or c-myc. Ndr1 expression is also activated by several chemicals: tunicamycin and homocysteine induce Ndr1 in human umbilical endothelial cells; nickel induces Ndr1 in several cell types. Members of this family are found in wide variety of multicellular eukaryotes, including an Ndr1 type protein in Helianthus annuus (sunflower), known as Sf21. Interestingly, the highest scoring matches in the noise are all alpha/beta hydrolases pfam00561, suggesting that this family may have an enzymatic function (Bateman A pers. obs.).


Pssm-ID: 397285 [Multi-domain]  Cd Length: 285  Bit Score: 466.44  E-value: 2.93e-166
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767990449   40 EHDIETPYGLLHVVIRGSPKGNRPAILTYHDVGLNHKLCFNTFFNFEDMQEITKHFVVCHVDAPGQQVGASQFPQGYQFP 119
Cdd:pfam03096   1 EHIIETPCGSVHVTVYGDPEGKKPPILTYHDLGLNHKSCFQGLFNSESMQEILENFCIYHVDAPGQEDGAASFPGGYPYP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767990449  120 SMEQLAAMLPSVVQHFGFKYVIGIGVGAGAYVLAKFALIFPDLVEGLVLVNIDPNGKGWIDWAATKLS-------GLTST 192
Cdd:pfam03096  81 SMDDLADMLPVVLDHFRLKSVIGMGVGAGAYILARFALKHPERVEGLVLINPTPKAAGWIEWFYNKLSskllyyyGMTDS 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767990449  193 LPDTVLSHLFSQEELVNNTELVQSYRQQIGNVVNQANLQLFWNMYNSRRDLDINRPGTvpnakTLRCPVMLVVGDNAPAE 272
Cdd:pfam03096 161 AKDYLLAHYFGKEELSNNSDIVQEYRKFLKERLNPKNLQLYLEAYNSRRDLTIERPGL-----ETKCPVLLVVGDNSPHV 235
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 767990449  273 DGVVECNSKLDPTTTTFLKMADSGGLPQVTQPGKLTEAFKYFLQGMGYIA 322
Cdd:pfam03096 236 DAVVECNTKLDPTKTTLLKVADCGGLVQQEQPGKLTESFKLFLQGMGYYP 285
MhpC COG0596
Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General ...
94-317 1.15e-10

Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only];


Pssm-ID: 223669 [Multi-domain]  Cd Length: 282  Bit Score: 61.57  E-value: 1.15e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767990449  94 HFVVCHVDAPGqqVGASQFPqgyqFPSMEQLAAMLPSVVQHFGFKYVIGIGVGAGAYVLAKFALIFPDLVEGLVLVNIDP 173
Cdd:COG0596   50 RYRVIAPDLRG--HGRSDPA----GYSLSAYADDLAALLDALGLEKVVLVGHSMGGAVALALALRHPDRVRGLVLIGPAP 123
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767990449 174 NGKGWIDWAATKLSGLTS------------------TLPDTVLSHLFSQEELVNNTELVQSYRQQIGNVVNQANLQLFWN 235
Cdd:COG0596  124 PPGLLEAALRQPAGAAPLaaladlllgldaaafaalLAALGLLAALAAAARAGLAEALRAPLLGAAAAAFARAARADLAA 203
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767990449 236 MYNSRRDLDINRPgtvpnAKTLRCPVMLVVGDNAP-AEDGVVECNSKLDPTTTTFLKMADSGGLPQVTQPGKLTEAFKYF 314
Cdd:COG0596  204 ALLALLDRDLRAA-----LARITVPTLIIHGEDDPvVPAELARRLAAALPNDARLVVIPGAGHFPHLEAPEAFAAALLAF 278

                 ...
gi 767990449 315 LQG 317
Cdd:COG0596  279 LER 281
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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