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Conserved domains on  [gi|767996407|ref|XP_011523752|]
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solute carrier family 13 member 2 isoform X1 [Homo sapiens]

Protein Classification

transporter permease( domain architecture ID 229430)

transporter permease similar to ArsB/NhaD family permeases, which typically contain 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ArsB_NhaD_permease super family cl21473
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ...
6-615 3.31e-129

Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.


The actual alignment was detected with superfamily member pfam00939:

Pssm-ID: 473875 [Multi-domain]  Cd Length: 472  Bit Score: 389.04  E-value: 3.31e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407    6 QALWAYRSYLIVFFVPILLLPLPILVPSKEAYCAYAIILMALFWCTEALPLAVTALFPLILFPMMGIVDASeiiqrpfps 85
Cdd:pfam00939   1 LTLWWKLLALLAVLLIILLLPAPDGLPSKAWHLFAIFIATIVGWILEPLPMAVIALFAISLSAILIGTLLA--------- 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407   86 sfespgecqsvgmsvtashnlggtvgdsrvfpplshVSTCQVAVEYLKDSNLLFFGGLLVAIAVEHWNLHKRIALRVLLI 165
Cdd:pfam00939  72 ------------------------------------KALSWALSGFSSTTTWLVFGAFFISAAFEKTGLGRRIALVLVKK 115
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407  166 VGVRPapLILGFMLVTAFLSMWISNTATSAMMVPIAHAVLDQLHSSqassnveegsNNPTFELQEPSpqkevtkldngqa 245
Cdd:pfam00939 116 MGKRT--LGLGYGLVFSDLLLAPATPSNTARAGGIVFPIIMSLPPA----------FGSDPEKGSER------------- 170
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407  246 lpvtsassegrahlsqkhlHLTQCMSLCVCYSASIGGIATLTGTAPNLVLQGQINSlfpQNGNVVNFASWFSFAFPTMVI 325
Cdd:pfam00939 171 -------------------RIGAYLMWTVYQSTSITSAMFLTAMAPNLLLLGLMNS---ILGVTITWASWFLAAIPPGVI 228
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407  326 LLLLAWLWLQILFLGFNFRKNfgigekmqeqqqAAYCVIQTEHRLLGPMTFAEKAISILFVILVLLWFTREpgfflgwgn 405
Cdd:pfam00939 229 LLLLAPLLLYVLYPPEIKSVP------------DAKAIAKTELKELGPMTFREKALLGLFVLLLLLWIFGG--------- 287
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407  406 laFPNakgesmVSDGTVAIFIGIIMFIipskfpgltqdpvenpgklkapLGLLDWK-TVNQKMPWNIVLLLGGGYALAKG 484
Cdd:pfam00939 288 --SLN------IDATTVAIIGLALMLL----------------------LRILDWKdIVKNKGAWNTLIWLGGLIMLANG 337
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407  485 SERSGLSEWLGNKLTPLQS--VPAPAIAIILSLLVATFTECTSNVATTTIFLPILASMAQAICLHP-LYVMLPCTLATSL 561
Cdd:pfam00939 338 LERSGFIEWLGNTLSTSLSgfSPAMAFIIILSLFYLSHYLFASATAHTAAMLPIFAAVAQAIPGAPpLLAALLLGFAISL 417
                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 767996407  562 A-FMLPVATPPNAIVFSFGDLKVLDMARAGFLLNIIGVLIIALAINSWGIPLFSL 615
Cdd:pfam00939 418 GgFLTPYGTGPGPIYFGSGYLKVKDWWRIGAILTIIGLLILLLLGNWWWKPLGSL 472
 
Name Accession Description Interval E-value
Na_sulph_symp pfam00939
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ...
6-615 3.31e-129

Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.


Pssm-ID: 279307 [Multi-domain]  Cd Length: 472  Bit Score: 389.04  E-value: 3.31e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407    6 QALWAYRSYLIVFFVPILLLPLPILVPSKEAYCAYAIILMALFWCTEALPLAVTALFPLILFPMMGIVDASeiiqrpfps 85
Cdd:pfam00939   1 LTLWWKLLALLAVLLIILLLPAPDGLPSKAWHLFAIFIATIVGWILEPLPMAVIALFAISLSAILIGTLLA--------- 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407   86 sfespgecqsvgmsvtashnlggtvgdsrvfpplshVSTCQVAVEYLKDSNLLFFGGLLVAIAVEHWNLHKRIALRVLLI 165
Cdd:pfam00939  72 ------------------------------------KALSWALSGFSSTTTWLVFGAFFISAAFEKTGLGRRIALVLVKK 115
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407  166 VGVRPapLILGFMLVTAFLSMWISNTATSAMMVPIAHAVLDQLHSSqassnveegsNNPTFELQEPSpqkevtkldngqa 245
Cdd:pfam00939 116 MGKRT--LGLGYGLVFSDLLLAPATPSNTARAGGIVFPIIMSLPPA----------FGSDPEKGSER------------- 170
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407  246 lpvtsassegrahlsqkhlHLTQCMSLCVCYSASIGGIATLTGTAPNLVLQGQINSlfpQNGNVVNFASWFSFAFPTMVI 325
Cdd:pfam00939 171 -------------------RIGAYLMWTVYQSTSITSAMFLTAMAPNLLLLGLMNS---ILGVTITWASWFLAAIPPGVI 228
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407  326 LLLLAWLWLQILFLGFNFRKNfgigekmqeqqqAAYCVIQTEHRLLGPMTFAEKAISILFVILVLLWFTREpgfflgwgn 405
Cdd:pfam00939 229 LLLLAPLLLYVLYPPEIKSVP------------DAKAIAKTELKELGPMTFREKALLGLFVLLLLLWIFGG--------- 287
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407  406 laFPNakgesmVSDGTVAIFIGIIMFIipskfpgltqdpvenpgklkapLGLLDWK-TVNQKMPWNIVLLLGGGYALAKG 484
Cdd:pfam00939 288 --SLN------IDATTVAIIGLALMLL----------------------LRILDWKdIVKNKGAWNTLIWLGGLIMLANG 337
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407  485 SERSGLSEWLGNKLTPLQS--VPAPAIAIILSLLVATFTECTSNVATTTIFLPILASMAQAICLHP-LYVMLPCTLATSL 561
Cdd:pfam00939 338 LERSGFIEWLGNTLSTSLSgfSPAMAFIIILSLFYLSHYLFASATAHTAAMLPIFAAVAQAIPGAPpLLAALLLGFAISL 417
                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 767996407  562 A-FMLPVATPPNAIVFSFGDLKVLDMARAGFLLNIIGVLIIALAINSWGIPLFSL 615
Cdd:pfam00939 418 GgFLTPYGTGPGPIYFGSGYLKVKDWWRIGAILTIIGLLILLLLGNWWWKPLGSL 472
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
39-609 8.08e-85

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 271.00  E-value: 8.08e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407  39 AYAIILMALFWCTEALPLAVTALFPLILFPMMGIVDASEiiqrpfpssfespgecqsvgmsvtashnlggtvgdsrvfpp 118
Cdd:cd01115    1 LAILVFAAVLFVTEALPLDVTALLVPVLLVLLGVVPPKE----------------------------------------- 39
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407 119 lshvstcqVAVEYLKDSNLLFFGGLLVAIAVEHWNLHKRIALRVLLIVGVRPAPLILGFMLVTAFLSMWISNTATSAMMV 198
Cdd:cd01115   40 --------AFSGFSDPAVILFLAGFILGAALTRTGLAKRIATKLLKRAGKGERRLLLLLMLVTAFLSAFMSNTATVAIML 111
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407 199 PIAHAVLDQLHSSQassnveegsnnptfelqepspqkevtkldngqalpvtsassegrahlsqkhlhltQCMSLCVCYSA 278
Cdd:cd01115  112 PVALGLAAKLDISP-------------------------------------------------------SRLLMPLAFAA 136
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407 279 SIGGIATLTGTAPNLVLQGQINSLFPQNGNvvnFASWFSFAFPTMVIllllawlwlqilflgfnfrknfgigekmqeqqq 358
Cdd:cd01115  137 SIGGMLTLIGTPPNLVASGYLESLGGQGFS---FFEFTPIGLPLLII--------------------------------- 180
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407 359 aaycviqtehrllgpmtfaekaisilfVILVLLWFTREPGFFLGWGNLAFPNA-KGESMVSDGTVAIFIGIIMFiipskf 437
Cdd:cd01115  181 ---------------------------GLLYLWFIFRLAVLIITIVLLAALAAiTGLLPVSVAIAIGAIVLVFG------ 227
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407 438 pgltqdpvenpgklkaplGLLDWKTVNQKMPWNIVLLLGGGYALAKGSERSGLSEWLGNKLTP-LQSVPAPAIAIILSLL 516
Cdd:cd01115  228 ------------------GVLLTKEDYKSIDWGIIFLFAGGIPLGKALESSGAAALIAEALISlLGGLPPFAILLLLCLL 289
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407 517 VATFTECTSNVATTTIFLPILASMAQAICLHPLYVMLPCTLATSLAFMLPVATPPNAIVFSFGDLKVLDMARAGFLLNII 596
Cdd:cd01115  290 TLVLTNFISNTATAVLLAPIALSIALSLGLPPEALLLAVAIGASCAFMLPVGTPPNAIVLGPGGYKFSDFAKVGLPLSIL 369
                        570
                 ....*....|...
gi 767996407 597 GVLIIALAINSWG 609
Cdd:cd01115  370 SLVVSVTMIPLIW 382
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
140-608 1.11e-76

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 248.92  E-value: 1.11e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407 140 FGGLLVAIAVEHWNLHKRIALRVLLIVGVRPAPLILGFMLVTAFLSMWISNTATSAMMVPIAHAVLDQLHSsqassnvEE 219
Cdd:COG0471    1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAALGS-------EK 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407 220 GSNNPTFelqepspqkevtkldngqalpvtsassegrahlsqkhlhltqcMSLCVCYSASIGGIATLTGTAPNLVLQGQI 299
Cdd:COG0471   74 RSKFGSA-------------------------------------------LLLPIAFAASIGGMGTLIGTPPNLIAAGLL 110
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407 300 NSLFPQNgnvVNFASWFSFAFPTMVILLLLAWLwlqilFLGFNFRKNFGIGEKMQEqqqaaycVIQTEHRLLGPMTFAEK 379
Cdd:COG0471  111 EEATGIP---ISFFEWMLVGLPVALVGLLLLWL-----VLYRLLPPEIKEVPGSKE-------VIREELAELGPLSRREK 175
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407 380 AISILFVILVLLWFTrepGFFLGwgnlafpnakgesmVSDGTVAIFIGIIMFIipskfpgltqdpvenpgklkapLGLLD 459
Cdd:COG0471  176 IALAIFALTVLLWIT---GSLHG--------------IPIAVVALLGAVLLLL----------------------TGVLT 216
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407 460 WKTVNQKMPWNIVLLLGGGYALAKGSERSGLSEWLGNKLTP-LQSVPAPAIAIILSLLVATFTECTSNVATTTIFLPILA 538
Cdd:COG0471  217 WKDAYKSIPWGVLLLFGGGLALGAALEKTGLAAWLADALLPlLGGLSPLLLLLLLALLTLLLTEFASNTATAALLLPIAI 296
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407 539 SMAQAICLHPLYVMLPCTLATSLAFMLPVATPPNAIVFSFGDLKVLDMARAGFLLNIIGVLIIALAINSW 608
Cdd:COG0471  297 SLAQALGVNPLPLALAVAFAASCAFLLPVGTPPNAIVYGSGYYKFKDFLKVGLPLNLIGLVVLLLLGPLW 366
dass TIGR00785
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ...
33-608 5.28e-43

anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273267 [Multi-domain]  Cd Length: 444  Bit Score: 160.59  E-value: 5.28e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407   33 SKEAYCAYAI-ILMALFWCTEALPLAVTALfplILFPMMGIVdaseiiqrpfpssfespgecqsvgmsvtashnlggtvg 111
Cdd:TIGR00785   7 NSGAWLLLAIfVAAIVGWILEPLPLPVTAL---LAIPIIAVL-------------------------------------- 45
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407  112 dsrvFPPLSHVSTcQVAVEYLKDSNL-LFFGGLLVAIAVEHWNLHKRIALRVLLIVGVRPAPL-ILGFMLVTAFLSMWIS 189
Cdd:TIGR00785  46 ----LGVLSAFKF-KNALSGFADPTIwLFFGAFILATALVKTGLGKRIAYKLVGKMGGTTLGLgYFLVFLETLLAPMWPS 120
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407  190 NTA-TSAMMVPIAHAVLDQLHSSqassnveegsnnptfelqepspqkevtkldngqalPVTSASSEGRAhlsqkhlhltq 268
Cdd:TIGR00785 121 NTArAGGILLPIIKSLLPLLGSK-----------------------------------PEKSPRKIGKY----------- 154
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407  269 cMSLCVCYSASIGGIATLTGTAPNLVLQGQinsLFPQNGNVVNFASWFSFAFPTMVILLLLAWLWLQILFLGfnfrknfg 348
Cdd:TIGR00785 155 -LMLGIAYSASIGSSGFLTGSAPNALAAGI---LSKILGIQISWGDWFLAGLPLGIILLLLVPLLLYVLFPP-------- 222
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407  349 igEKMQEQQQAAycVIQTEHRLLGPMTFAEKAISILFVILVLLWFTrepGFFLGwgnlafpnakgesmVSDGTVAIFIGI 428
Cdd:TIGR00785 223 --ELKLKDEVDL--WAKEELEEMGPMSFREKALLGIFLLALLLWIF---GGSLG--------------INASVVALLAVV 281
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407  429 imfiipskfpgltqdpvenpgkLKAPLGLLDWKTVNQ-KMPWNIVLLLGGGYALAKGSERSGLSEWLGNKLTPLQSVPAP 507
Cdd:TIGR00785 282 ----------------------LMLFLGIVTWKDIQKnKVAWNTLILFGGLIGLAGGLKKSGFIKWFSEKLVGILDGLSP 339
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407  508 AIAIILSLLVATF--TECTSNVATTTIFLPILASMAQAICLHPLYVMLPCTLATSLA-FMLPVATPPNAIVFSFGDLKVL 584
Cdd:TIGR00785 340 TIAVLVLVVLFYIilYFFASNTAHTAALVPIFFSVASAQGIPLELLALALALSASLMgFLTPYATPPNAIAYGSGYVKIK 419
                         570       580
                  ....*....|....*....|....
gi 767996407  585 DMARAGFLLNIIGVLIIALAINSW 608
Cdd:TIGR00785 420 DMWRVGAIIGIVGLIVLLLVGTLW 443
 
Name Accession Description Interval E-value
Na_sulph_symp pfam00939
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ...
6-615 3.31e-129

Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.


Pssm-ID: 279307 [Multi-domain]  Cd Length: 472  Bit Score: 389.04  E-value: 3.31e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407    6 QALWAYRSYLIVFFVPILLLPLPILVPSKEAYCAYAIILMALFWCTEALPLAVTALFPLILFPMMGIVDASeiiqrpfps 85
Cdd:pfam00939   1 LTLWWKLLALLAVLLIILLLPAPDGLPSKAWHLFAIFIATIVGWILEPLPMAVIALFAISLSAILIGTLLA--------- 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407   86 sfespgecqsvgmsvtashnlggtvgdsrvfpplshVSTCQVAVEYLKDSNLLFFGGLLVAIAVEHWNLHKRIALRVLLI 165
Cdd:pfam00939  72 ------------------------------------KALSWALSGFSSTTTWLVFGAFFISAAFEKTGLGRRIALVLVKK 115
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407  166 VGVRPapLILGFMLVTAFLSMWISNTATSAMMVPIAHAVLDQLHSSqassnveegsNNPTFELQEPSpqkevtkldngqa 245
Cdd:pfam00939 116 MGKRT--LGLGYGLVFSDLLLAPATPSNTARAGGIVFPIIMSLPPA----------FGSDPEKGSER------------- 170
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407  246 lpvtsassegrahlsqkhlHLTQCMSLCVCYSASIGGIATLTGTAPNLVLQGQINSlfpQNGNVVNFASWFSFAFPTMVI 325
Cdd:pfam00939 171 -------------------RIGAYLMWTVYQSTSITSAMFLTAMAPNLLLLGLMNS---ILGVTITWASWFLAAIPPGVI 228
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407  326 LLLLAWLWLQILFLGFNFRKNfgigekmqeqqqAAYCVIQTEHRLLGPMTFAEKAISILFVILVLLWFTREpgfflgwgn 405
Cdd:pfam00939 229 LLLLAPLLLYVLYPPEIKSVP------------DAKAIAKTELKELGPMTFREKALLGLFVLLLLLWIFGG--------- 287
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407  406 laFPNakgesmVSDGTVAIFIGIIMFIipskfpgltqdpvenpgklkapLGLLDWK-TVNQKMPWNIVLLLGGGYALAKG 484
Cdd:pfam00939 288 --SLN------IDATTVAIIGLALMLL----------------------LRILDWKdIVKNKGAWNTLIWLGGLIMLANG 337
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407  485 SERSGLSEWLGNKLTPLQS--VPAPAIAIILSLLVATFTECTSNVATTTIFLPILASMAQAICLHP-LYVMLPCTLATSL 561
Cdd:pfam00939 338 LERSGFIEWLGNTLSTSLSgfSPAMAFIIILSLFYLSHYLFASATAHTAAMLPIFAAVAQAIPGAPpLLAALLLGFAISL 417
                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 767996407  562 A-FMLPVATPPNAIVFSFGDLKVLDMARAGFLLNIIGVLIIALAINSWGIPLFSL 615
Cdd:pfam00939 418 GgFLTPYGTGPGPIYFGSGYLKVKDWWRIGAILTIIGLLILLLLGNWWWKPLGSL 472
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
39-609 8.08e-85

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 271.00  E-value: 8.08e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407  39 AYAIILMALFWCTEALPLAVTALFPLILFPMMGIVDASEiiqrpfpssfespgecqsvgmsvtashnlggtvgdsrvfpp 118
Cdd:cd01115    1 LAILVFAAVLFVTEALPLDVTALLVPVLLVLLGVVPPKE----------------------------------------- 39
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407 119 lshvstcqVAVEYLKDSNLLFFGGLLVAIAVEHWNLHKRIALRVLLIVGVRPAPLILGFMLVTAFLSMWISNTATSAMMV 198
Cdd:cd01115   40 --------AFSGFSDPAVILFLAGFILGAALTRTGLAKRIATKLLKRAGKGERRLLLLLMLVTAFLSAFMSNTATVAIML 111
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407 199 PIAHAVLDQLHSSQassnveegsnnptfelqepspqkevtkldngqalpvtsassegrahlsqkhlhltQCMSLCVCYSA 278
Cdd:cd01115  112 PVALGLAAKLDISP-------------------------------------------------------SRLLMPLAFAA 136
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407 279 SIGGIATLTGTAPNLVLQGQINSLFPQNGNvvnFASWFSFAFPTMVIllllawlwlqilflgfnfrknfgigekmqeqqq 358
Cdd:cd01115  137 SIGGMLTLIGTPPNLVASGYLESLGGQGFS---FFEFTPIGLPLLII--------------------------------- 180
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407 359 aaycviqtehrllgpmtfaekaisilfVILVLLWFTREPGFFLGWGNLAFPNA-KGESMVSDGTVAIFIGIIMFiipskf 437
Cdd:cd01115  181 ---------------------------GLLYLWFIFRLAVLIITIVLLAALAAiTGLLPVSVAIAIGAIVLVFG------ 227
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407 438 pgltqdpvenpgklkaplGLLDWKTVNQKMPWNIVLLLGGGYALAKGSERSGLSEWLGNKLTP-LQSVPAPAIAIILSLL 516
Cdd:cd01115  228 ------------------GVLLTKEDYKSIDWGIIFLFAGGIPLGKALESSGAAALIAEALISlLGGLPPFAILLLLCLL 289
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407 517 VATFTECTSNVATTTIFLPILASMAQAICLHPLYVMLPCTLATSLAFMLPVATPPNAIVFSFGDLKVLDMARAGFLLNII 596
Cdd:cd01115  290 TLVLTNFISNTATAVLLAPIALSIALSLGLPPEALLLAVAIGASCAFMLPVGTPPNAIVLGPGGYKFSDFAKVGLPLSIL 369
                        570
                 ....*....|...
gi 767996407 597 GVLIIALAINSWG 609
Cdd:cd01115  370 SLVVSVTMIPLIW 382
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
140-608 1.11e-76

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 248.92  E-value: 1.11e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407 140 FGGLLVAIAVEHWNLHKRIALRVLLIVGVRPAPLILGFMLVTAFLSMWISNTATSAMMVPIAHAVLDQLHSsqassnvEE 219
Cdd:COG0471    1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAALGS-------EK 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407 220 GSNNPTFelqepspqkevtkldngqalpvtsassegrahlsqkhlhltqcMSLCVCYSASIGGIATLTGTAPNLVLQGQI 299
Cdd:COG0471   74 RSKFGSA-------------------------------------------LLLPIAFAASIGGMGTLIGTPPNLIAAGLL 110
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407 300 NSLFPQNgnvVNFASWFSFAFPTMVILLLLAWLwlqilFLGFNFRKNFGIGEKMQEqqqaaycVIQTEHRLLGPMTFAEK 379
Cdd:COG0471  111 EEATGIP---ISFFEWMLVGLPVALVGLLLLWL-----VLYRLLPPEIKEVPGSKE-------VIREELAELGPLSRREK 175
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407 380 AISILFVILVLLWFTrepGFFLGwgnlafpnakgesmVSDGTVAIFIGIIMFIipskfpgltqdpvenpgklkapLGLLD 459
Cdd:COG0471  176 IALAIFALTVLLWIT---GSLHG--------------IPIAVVALLGAVLLLL----------------------TGVLT 216
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407 460 WKTVNQKMPWNIVLLLGGGYALAKGSERSGLSEWLGNKLTP-LQSVPAPAIAIILSLLVATFTECTSNVATTTIFLPILA 538
Cdd:COG0471  217 WKDAYKSIPWGVLLLFGGGLALGAALEKTGLAAWLADALLPlLGGLSPLLLLLLLALLTLLLTEFASNTATAALLLPIAI 296
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407 539 SMAQAICLHPLYVMLPCTLATSLAFMLPVATPPNAIVFSFGDLKVLDMARAGFLLNIIGVLIIALAINSW 608
Cdd:COG0471  297 SLAQALGVNPLPLALAVAFAASCAFLLPVGTPPNAIVYGSGYYKFKDFLKVGLPLNLIGLVVLLLLGPLW 366
dass TIGR00785
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ...
33-608 5.28e-43

anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273267 [Multi-domain]  Cd Length: 444  Bit Score: 160.59  E-value: 5.28e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407   33 SKEAYCAYAI-ILMALFWCTEALPLAVTALfplILFPMMGIVdaseiiqrpfpssfespgecqsvgmsvtashnlggtvg 111
Cdd:TIGR00785   7 NSGAWLLLAIfVAAIVGWILEPLPLPVTAL---LAIPIIAVL-------------------------------------- 45
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407  112 dsrvFPPLSHVSTcQVAVEYLKDSNL-LFFGGLLVAIAVEHWNLHKRIALRVLLIVGVRPAPL-ILGFMLVTAFLSMWIS 189
Cdd:TIGR00785  46 ----LGVLSAFKF-KNALSGFADPTIwLFFGAFILATALVKTGLGKRIAYKLVGKMGGTTLGLgYFLVFLETLLAPMWPS 120
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407  190 NTA-TSAMMVPIAHAVLDQLHSSqassnveegsnnptfelqepspqkevtkldngqalPVTSASSEGRAhlsqkhlhltq 268
Cdd:TIGR00785 121 NTArAGGILLPIIKSLLPLLGSK-----------------------------------PEKSPRKIGKY----------- 154
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407  269 cMSLCVCYSASIGGIATLTGTAPNLVLQGQinsLFPQNGNVVNFASWFSFAFPTMVILLLLAWLWLQILFLGfnfrknfg 348
Cdd:TIGR00785 155 -LMLGIAYSASIGSSGFLTGSAPNALAAGI---LSKILGIQISWGDWFLAGLPLGIILLLLVPLLLYVLFPP-------- 222
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407  349 igEKMQEQQQAAycVIQTEHRLLGPMTFAEKAISILFVILVLLWFTrepGFFLGwgnlafpnakgesmVSDGTVAIFIGI 428
Cdd:TIGR00785 223 --ELKLKDEVDL--WAKEELEEMGPMSFREKALLGIFLLALLLWIF---GGSLG--------------INASVVALLAVV 281
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407  429 imfiipskfpgltqdpvenpgkLKAPLGLLDWKTVNQ-KMPWNIVLLLGGGYALAKGSERSGLSEWLGNKLTPLQSVPAP 507
Cdd:TIGR00785 282 ----------------------LMLFLGIVTWKDIQKnKVAWNTLILFGGLIGLAGGLKKSGFIKWFSEKLVGILDGLSP 339
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407  508 AIAIILSLLVATF--TECTSNVATTTIFLPILASMAQAICLHPLYVMLPCTLATSLA-FMLPVATPPNAIVFSFGDLKVL 584
Cdd:TIGR00785 340 TIAVLVLVVLFYIilYFFASNTAHTAALVPIFFSVASAQGIPLELLALALALSASLMgFLTPYATPPNAIAYGSGYVKIK 419
                         570       580
                  ....*....|....*....|....
gi 767996407  585 DMARAGFLLNIIGVLIIALAINSW 608
Cdd:TIGR00785 420 DMWRVGAIIGIVGLIVLLLVGTLW 443
ArsB_NhaD_permease cd00625
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ...
46-605 1.58e-36

Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.


Pssm-ID: 238344 [Multi-domain]  Cd Length: 396  Bit Score: 141.23  E-value: 1.58e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407  46 ALFWCTEALPLAVTALFPLILFPMMGIVDASEIIQrpfpssfespgecqsvgmsvtashnlggtvgdsrvfpplshvstc 125
Cdd:cd00625    1 YVLIRPEKLPRAVVALLGAVLLVLLGVVSPKEALS--------------------------------------------- 35
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407 126 qvavEYLKDSNLLFFGGLLVAIAVEHWNLHKRIALRVLLIvGVRPAPLILGFMLVTAFLSMWISNTATSAMMVPIAHAVL 205
Cdd:cd00625   36 ----AIDWETILLLFGMMILSAALEETGLFDRLAAKLARA-SKGSRRLLLLLMLLTAALSAFFSNDATAVLLTPIVLALL 110
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407 206 DQLHSSQassnveegsnnptfelqepspqkevtkldngqalpvtsassegrahlsqkhlhlTQCMSLCVCYSASIGGIAT 285
Cdd:cd00625  111 RKLGLSP------------------------------------------------------PVPLLLALAFAANIGGAAT 136
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407 286 LTGTAPNLVLQGQINslfpqngnvVNFASWFSFAFPTMVILLLLAWLWLQILFLGFNFRKNFGIGEKMQEQQQAAYcviq 365
Cdd:cd00625  137 PIGNPPNLIIASLSG---------LGFLDFLAFMAPPALGLLLLLLGLLYLLFRKKLLLPDEDKLTVLAEPLPARP---- 203
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407 366 tehrllgpmTFAEKAISILFVILVLLWFtrepGFFLGWGNLafpnakgesMVSDGTVAIFIGIIMFiipskfpgltqdpv 445
Cdd:cd00625  204 ---------LLKKFLLLALLLLLLFVLL----FFFLIPLGL---------IALLGALLLLLLLVRG-------------- 247
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407 446 enpgklkaplglLDWKTVNQKMPWNIVLLLGGGYALAKGSERSGLSEWLGNKLTPLQSVPAPAIAIILSLLVATFTECTS 525
Cdd:cd00625  248 ------------LDPEEVLKSVDWGTLLFFAGLFVLVGALESTGLLEWLAELLVALVGLPPLAALLLIGLLSALLSNFIS 315
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407 526 NVATTTIFLPILASM-----AQAICLHPLYVMLPCTLATSLAFMLPVATPPNAIVfsfgDLKVLDMARAGFLLNIIGVLI 600
Cdd:cd00625  316 NVPTVALLLPIAASLappepAWLALALGSTLGGNLTLIGSLANLIPLGAAENAGV----GISFGEFLKVGLPLTLLSLVV 391

                 ....*
gi 767996407 601 IALAI 605
Cdd:cd00625  392 SLLYL 396
CitMHS pfam03600
Citrate transporter;
137-553 1.69e-21

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 96.23  E-value: 1.69e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407  137 LLFFGGLLVAIAVEHWNLHKRIALRVLLIVGVRPAPLILGFMLVTAFLSMWISNTATSAMMVPIAHAVLDQLHSSqassn 216
Cdd:pfam03600  43 LLLLGMMIIGAILERTGLFDRLALKLLRLAGGKPRRLLVALMLATALLSAFLSNDGTVLIMIPIVLALARRLGLP----- 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407  217 veegsnnptfelqePSPqkevtkldngqalpvtsassegrahlsqkhlhltqcMSLCVCYSASIGGIATLTGTAPNLVLQ 296
Cdd:pfam03600 118 --------------PSP------------------------------------LLIALAFAANIGGTATPIGDPPNIIIA 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407  297 GQINSLFPQNGNVVNFASWFSFAFPTMVillllawlwlqilFLGFNFRKNFGIGEKMQEQQQAAYCVIQTEHRLLGpmtf 376
Cdd:pfam03600 148 SALGLSFGDFGFFMFPPVGVALLLVGLL-------------PLLLIFRKLLPVRKEEEAELEELRKRAIKDKLLLA---- 210
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407  377 aekaisILFVILVLLWFTREPGFFLGWGNLAfpnakgesmvsdgtvaifigiimfiipskfpgltqdpvenpgkLKAPLG 456
Cdd:pfam03600 211 ------ISALVLALVILGFLLLSVLALAGAL-------------------------------------------LLLLTG 241
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407  457 LLDWKTVNQKMPWNIVLLLGGGYALAKGSERSGLSEWLGNKLTPLqsVPAPAIAIILSLLVATFTECTSNVATTTIFLPI 536
Cdd:pfam03600 242 VLDPEEALKAVDWSTLLFFAGLFILVGALEKTGLADALADALGGL--SGLLVALALILWLSALLSAFISNVPTAALMAPI 319
                         410
                  ....*....|....*..
gi 767996407  537 LASMAQAICLHPLYVML 553
Cdd:pfam03600 320 IVGMAPAAGLGDPDPLA 336
CitMHS pfam03600
Citrate transporter;
454-605 1.29e-10

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 63.49  E-value: 1.29e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407  454 PLGLLDWKTVNQKMPWNIVLLLGGGYALAKGSERSGLSEWLGNKLTPLQSVPAPAIAIILSLLVATFTECTSNVATTTIF 533
Cdd:pfam03600  24 LLGVLTPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGKPRRLLVALMLATALLSAFLSNDGTVLIM 103
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767996407  534 LPILASMAQAICLHPLYVMLPCTLATSLAFML-PVATPPNAIVFSFGDLKVLDMARAGFLLNIIGVLIIALAI 605
Cdd:pfam03600 104 IPIVLALARRLGLPPSPLLIALAFAANIGGTAtPIGDPPNIIIASALGLSFGDFGFFMFPPVGVALLLVGLLP 176
ArsB COG1055
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
455-605 7.59e-08

Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];


Pssm-ID: 440675 [Multi-domain]  Cd Length: 415  Bit Score: 55.13  E-value: 7.59e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407 455 LGLLDWKTVNQKMPWNIVLLLGGGYALAKGSERSGLSEWLGNKLTPLQSVPAPAIAIILSLLVATFTECTSNVATTTIFL 534
Cdd:COG1055   39 LGVVSLEDALEAIDWNTILFLLGMMIIVAILDESGFFEWLAIKLARRAKGSPRRLLWLLGLLTALLSAFLDNDTTALLLT 118
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767996407 535 PILASMAQAICLHPLYVMLPCTLATSLA-FMLPVATPPNAIVFSFGDLKVLDMARAGFLLNIIGVLIIALAI 605
Cdd:COG1055  119 PVVLAIARRLGLNPVPFLIAIVFAANIGgAATPIGNPTNIMIASAGGLSFLDFLANLFPPSLVSLLVTLLVL 190
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
470-612 1.29e-07

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 54.13  E-value: 1.29e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407 470 NIVLLLGGGYALAKGSERSGLSEWLGNKLTPLQSVPAPAIAIILSLLVATFTECTSNVATTTIFLPILASMAQAICLHPL 549
Cdd:cd01115   47 PAVILFLAGFILGAALTRTGLAKRIATKLLKRAGKGERRLLLLLMLVTAFLSAFMSNTATVAIMLPVALGLAAKLDISPS 126
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407 550 YVMLPCTLATSLAFML-PVATPPNAIV------FSFGDLKVLDMARAGFLLNIIGVLIIALAINSWGIPL 612
Cdd:cd01115  127 RLLMPLAFAASIGGMLtLIGTPPNLVAsgylesLGGQGFSFFEFTPIGLPLLIIGLLYLWFIFRLAVLII 196
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
137-209 4.48e-04

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 42.83  E-value: 4.48e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767996407 137 LLFFGGLL-VAIAVEHWNLHKRIALRVL-LIVGVRPAPLILGFMLVTAFLSMWISNTATSAMMVPIAHAVLDQLH 209
Cdd:COG0471  229 LLLFGGGLaLGAALEKTGLAAWLADALLpLLGGLSPLLLLLLLALLTLLLTEFASNTATAALLLPIAISLAQALG 303
CitMHS pfam03600
Citrate transporter;
54-214 1.01e-03

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 41.91  E-value: 1.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407   54 LPLAVTALFPLILF----PMMGIVDASEIIQRPFPSSFESPGECQSVGMSVTASHNLGGTVGDSRVFPPLSHVSTCQVAV 129
Cdd:pfam03600 167 VALLLVGLLPLLLIfrklLPVRKEEEAELEELRKRAIKDKLLLAISALVLALVILGFLLLSVLALAGALLLLLTGVLDPE 246
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407  130 EYLKD---SNLLFFGGLL-VAIAVEHWNLHKRIAlrVLLIVGVRPAPLILGFMLVTAFLSMWISNTATSAMMVPIAHAVL 205
Cdd:pfam03600 247 EALKAvdwSTLLFFAGLFiLVGALEKTGLADALA--DALGGLSGLLVALALILWLSALLSAFISNVPTAALMAPIIVGMA 324

                  ....*....
gi 767996407  206 DQLHSSQAS 214
Cdd:pfam03600 325 PAAGLGDPD 333
ArsB COG1055
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
137-208 4.41e-03

Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];


Pssm-ID: 440675 [Multi-domain]  Cd Length: 415  Bit Score: 39.73  E-value: 4.41e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767996407 137 LLFFGGLLVAIAVEHWNLHKRIALRVLLIVGVRPAPLILGFMLVTAFLSMWISNTATSAMMVPIAHAVLDQL 208
Cdd:COG1055   57 LFLLGMMIIVAILDESGFFEWLAIKLARRAKGSPRRLLWLLGLLTALLSAFLDNDTTALLLTPVVLAIARRL 128
P_permease cd01116
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ...
456-605 9.10e-03

Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.


Pssm-ID: 238536 [Multi-domain]  Cd Length: 413  Bit Score: 38.77  E-value: 9.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996407 456 GLLDWKTVNQKMPWNIVLLLGGGYALAKGSERSGLSEWLGNKLTPLQSVPAPAIAIILSLLVATFTECTSNVATTTIFLP 535
Cdd:cd01116   34 LSPDLETIVSWVDWETLALLLGMMIIVSILSETGVFEYLAIWAVKISKGRPWRLLLLLGLLTAFLSAFLDNVTTVLLMVP 113
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767996407 536 ILASMAQAICLHPLYVMLPCTLATSLAFML-PVATPPNAIVFSFGDLKVLDmaragFLLNIIGVLIIALAI 605
Cdd:cd01116  114 VTIRLCEVLGLNPVPVLISEVIAANIGGAAtLIGDPPNIMIGSAAGLTFND-----FLLHMLPSVVLALVV 179
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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