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Conserved domains on  [gi|768008519|ref|XP_011525144|]
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WD repeat-containing protein 62 isoform X15 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-219 6.80e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 114.74  E-value: 6.80e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008519   10 HDAEVLCLEYSkpeTGLTLLASASRDRLIHVLNVEKNyNLEQTLDDHSSSITAIKFAGNRDiQMISCGADKSIYFRSAQQ 89
Cdd:cd00200     8 HTGGVTCVAFS---PDGKLLATGSGDGTIKVWDLETG-ELLRTLKGHTGPVRDVAASADGT-YLASGSSDKTIRLWDLET 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008519   90 GsdglHFVRTHHVAEKTtLYDMDIDITQKYVAVACQDRNVRVYNTVNGKQKKCYKGSQGDegsLLKVHVDPSGTFLATSC 169
Cdd:cd00200    83 G----ECVRTLTGHTSY-VSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDW---VNSVAFSPDGTFVASSS 154

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 768008519  170 SDKSISVIDFYSGECIAKMFGHSEIITSMKFTYDCHHLITVSGDSCVFIW 219
Cdd:cd00200   155 QDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLW 204
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 660-890 1.73e-06

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 52.25  E-value: 1.73e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008519  660 PASSVLPTDRNLPTPTSAPTP-----GLAQGVHAPSTCSYMEATASSRARISRSISLGDSEGPIVATLAQPLRR--PSSV 732
Cdd:PHA03247 2613 PPSPLPPDTHAPDPPPPSPSPaanepDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRaaRPTV 2692

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008519  733 GELASLGQelqaittattPSLDSEGQEPALRSWgnhearanlrltlssaCDGLLQPPVDTQPGVTVPAVSF-PAPSPVEE 811
Cdd:PHA03247 2693 GSLTSLAD----------PPPPPPTPEPAPHAL----------------VSATPLPPGPAAARQASPALPAaPAPPAVPA 2746

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 768008519  812 SALRLHGSAFRPSLPAPESPGLPAHPSNPQLPEARPGIPGGTASLLEPTSGAlgllqgsPARWSEPWVPVEALPPSPLE 890
Cdd:PHA03247 2747 GPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESL-------PSPWDPADPPAAVLAPAAAL 2818
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-219 6.80e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 114.74  E-value: 6.80e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008519   10 HDAEVLCLEYSkpeTGLTLLASASRDRLIHVLNVEKNyNLEQTLDDHSSSITAIKFAGNRDiQMISCGADKSIYFRSAQQ 89
Cdd:cd00200     8 HTGGVTCVAFS---PDGKLLATGSGDGTIKVWDLETG-ELLRTLKGHTGPVRDVAASADGT-YLASGSSDKTIRLWDLET 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008519   90 GsdglHFVRTHHVAEKTtLYDMDIDITQKYVAVACQDRNVRVYNTVNGKQKKCYKGSQGDegsLLKVHVDPSGTFLATSC 169
Cdd:cd00200    83 G----ECVRTLTGHTSY-VSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDW---VNSVAFSPDGTFVASSS 154

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 768008519  170 SDKSISVIDFYSGECIAKMFGHSEIITSMKFTYDCHHLITVSGDSCVFIW 219
Cdd:cd00200   155 QDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLW 204
WD40 COG2319
WD40 repeat [General function prediction only];
3-221 1.58e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 101.14  E-value: 1.58e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008519    3 ELVKVEAHDAEVLCLEYSkPEtGlTLLASASRDRLIHVLNVEKNyNLEQTLDDHSSSITAIKFAGNRDIqMISCGADKSI 82
Cdd:COG2319   196 LLRTLTGHTGAVRSVAFS-PD-G-KLLASGSADGTVRLWDLATG-KLLRTLTGHSGSVRSVAFSPDGRL-LASGSADGTV 270

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008519   83 YFRSAQQGSdgLHFVRTHHVAektTLYDMDIDITQKYVAVACQDRNVRVYNTVNGKQKKCYKGSQGDEGSllkVHVDPSG 162
Cdd:COG2319   271 RLWDLATGE--LLRTLTGHSG---GVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS---VAFSPDG 342

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 768008519  163 TFLATSCSDKSISVIDFYSGECIAKMFGHSEIITSMKFTYDCHHLITVSGDSCVFIWHL 221
Cdd:COG2319   343 KTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
PHA03247 PHA03247
large tegument protein UL36; Provisional
 660-890 1.73e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 52.25  E-value: 1.73e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008519  660 PASSVLPTDRNLPTPTSAPTP-----GLAQGVHAPSTCSYMEATASSRARISRSISLGDSEGPIVATLAQPLRR--PSSV 732
Cdd:PHA03247 2613 PPSPLPPDTHAPDPPPPSPSPaanepDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRaaRPTV 2692

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008519  733 GELASLGQelqaittattPSLDSEGQEPALRSWgnhearanlrltlssaCDGLLQPPVDTQPGVTVPAVSF-PAPSPVEE 811
Cdd:PHA03247 2693 GSLTSLAD----------PPPPPPTPEPAPHAL----------------VSATPLPPGPAAARQASPALPAaPAPPAVPA 2746

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 768008519  812 SALRLHGSAFRPSLPAPESPGLPAHPSNPQLPEARPGIPGGTASLLEPTSGAlgllqgsPARWSEPWVPVEALPPSPLE 890
Cdd:PHA03247 2747 GPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESL-------PSPWDPADPPAAVLAPAAAL 2818
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 181-220 3.96e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 3.96e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 768008519    181 SGECIAKMFGHSEIITSMKFTYDCHHLITVSGDSCVFIWH 220
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
182-219 3.28e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 3.28e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 768008519   182 GECIAKMFGHSEIITSMKFTYDCHHLITVSGDSCVFIW 219
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 647-886 6.50e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.52  E-value: 6.50e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008519   647 PPPPCLTSLASCVPASSVlPTDRNLPTPTSAPTPGLAQGVHAPSTCSYMEATASSRARISRSISLGD--SEGPIVATLAQ 724
Cdd:pfam03154  186 PPPPGTTQAATAGPTPSA-PSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPSPHPPLQPmtQPPPPSQVSPQ 264

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008519   725 PLRRPSSVGELASLGQELQaittaTTPSLDSEGQEPALRSWGNHEARANLRLTLSSACDGLLQ-----PPVDTQPGVTVP 799
Cdd:pfam03154  265 PLPQPSLHGQMPPMPHSLQ-----TGPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQqrihtPPSQSQLQSQQP 339

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008519   800 AVSFP-APSPVEESALRLHGSAFRPSLPAPESPGLPAHPSNP---QLPEARPGIPG----GTASLLEPTSGALGLLQGSP 871
Cdd:pfam03154  340 PREQPlPPAPLSMPHIKPPPTTPIPQLPNPQSHKHPPHLSGPspfQMNSNLPPPPAlkplSSLSTHHPPSAHPPPLQLMP 419

                          250
                   ....*....|....*
gi 768008519   872 ArwSEPWVPVEALPP 886
Cdd:pfam03154  420 Q--SQQLPPPPAQPP 432
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-219 6.80e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 114.74  E-value: 6.80e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008519   10 HDAEVLCLEYSkpeTGLTLLASASRDRLIHVLNVEKNyNLEQTLDDHSSSITAIKFAGNRDiQMISCGADKSIYFRSAQQ 89
Cdd:cd00200     8 HTGGVTCVAFS---PDGKLLATGSGDGTIKVWDLETG-ELLRTLKGHTGPVRDVAASADGT-YLASGSSDKTIRLWDLET 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008519   90 GsdglHFVRTHHVAEKTtLYDMDIDITQKYVAVACQDRNVRVYNTVNGKQKKCYKGSQGDegsLLKVHVDPSGTFLATSC 169
Cdd:cd00200    83 G----ECVRTLTGHTSY-VSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDW---VNSVAFSPDGTFVASSS 154

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 768008519  170 SDKSISVIDFYSGECIAKMFGHSEIITSMKFTYDCHHLITVSGDSCVFIW 219
Cdd:cd00200   155 QDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLW 204
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 3-219 5.16e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 100.49  E-value: 5.16e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008519    3 ELVKVEAHDAEVLCLEYSKpetGLTLLASASRDRLIHVLNVEkNYNLEQTLDDHSSSITAIKFAGNRDIQmISCGADKSI 82
Cdd:cd00200    85 CVRTLTGHTSYVSSVAFSP---DGRILSSSSRDKTIKVWDVE-TGKCLTTLRGHTDWVNSVAFSPDGTFV-ASSSQDGTI 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008519   83 YFRSAQQGSdglhFVRTHHvAEKTTLYDMDIDITQKYVAVACQDRNVRVYNTVNGKQKKCYkgsQGDEGSLLKVHVDPSG 162
Cdd:cd00200   160 KLWDLRTGK----CVATLT-GHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTL---RGHENGVNSVAFSPDG 231

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 768008519  163 TFLATSCSDKSISVIDFYSGECIAKMFGHSEIITSMKFTYDCHHLITVSGDSCVFIW 219
Cdd:cd00200   232 YLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
3-221 1.58e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 101.14  E-value: 1.58e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008519    3 ELVKVEAHDAEVLCLEYSkPEtGlTLLASASRDRLIHVLNVEKNyNLEQTLDDHSSSITAIKFAGNRDIqMISCGADKSI 82
Cdd:COG2319   196 LLRTLTGHTGAVRSVAFS-PD-G-KLLASGSADGTVRLWDLATG-KLLRTLTGHSGSVRSVAFSPDGRL-LASGSADGTV 270

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008519   83 YFRSAQQGSdgLHFVRTHHVAektTLYDMDIDITQKYVAVACQDRNVRVYNTVNGKQKKCYKGSQGDEGSllkVHVDPSG 162
Cdd:COG2319   271 RLWDLATGE--LLRTLTGHSG---GVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS---VAFSPDG 342

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 768008519  163 TFLATSCSDKSISVIDFYSGECIAKMFGHSEIITSMKFTYDCHHLITVSGDSCVFIWHL 221
Cdd:COG2319   343 KTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
3-222 1.25e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 89.59  E-value: 1.25e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008519    3 ELVKVEAHDAEVLCLEYSkPETglTLLASASRDRLIHVLNVEKNyNLEQTLDDHSSSITAIKFAGNRDiQMISCGADKSI 82
Cdd:COG2319   112 LLRTLTGHTGAVRSVAFS-PDG--KTLASGSADGTVRLWDLATG-KLLRTLTGHSGAVTSVAFSPDGK-LLASGSDDGTV 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008519   83 YFRSAQQGSDgLHFVRTHhvaeKTTLYDMDIDITQKYVAVACQDRNVRVYNTVNGKQKKCYKGsqgDEGSLLKVHVDPSG 162
Cdd:COG2319   187 RLWDLATGKL-LRTLTGH----TGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTG---HSGSVRSVAFSPDG 258

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008519  163 TFLATSCSDKSISVIDFYSGECIAKMFGHSEIITSMKFTYDCHHLITVSGDSCVFIWHLG 222
Cdd:COG2319   259 RLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA 318
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 109-221 7.99e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 73.14  E-value: 7.99e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008519  109 YDMDIDITQKYVAVACQDRNVRVYNTVNGKQKKCYKGSqgdEGSLLKVHVDPSGTFLATSCSDKSISVIDFYSGECIAKM 188
Cdd:cd00200    13 TCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGH---TGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTL 89

                          90       100       110
                  ....*....|....*....|....*....|...
gi 768008519  189 FGHSEIITSMKFTYDCHHLITVSGDSCVFIWHL 221
Cdd:cd00200    90 TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV 122
WD40 COG2319
WD40 repeat [General function prediction only];
24-221 4.81e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 72.25  E-value: 4.81e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008519   24 TGLTLLASASRDRLIHVLNVEKNyNLEQTLDDHSSSITAIKFAGNRDiQMISCGADKSIYFRSAQQGSDGLHFVRTHHva 103
Cdd:COG2319    46 PDGARLAAGAGDLTLLLLDAAAG-ALLATLLGHTAAVLSVAFSPDGR-LLASASADGTVRLWDLATGLLLRTLTGHTG-- 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008519  104 ektTLYDMDIDITQKYVAVACQDRNVRVYNTVNGKQKKCYKGSQGDEGSllkVHVDPSGTFLATSCSDKSISVIDFYSGE 183
Cdd:COG2319   122 ---AVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTS---VAFSPDGKLLASGSDDGTVRLWDLATGK 195

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 768008519  184 CIAKMFGHSEIITSMKFTYDCHHLITVSGDSCVFIWHL 221
Cdd:COG2319   196 LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDL 233
PHA03247 PHA03247
large tegument protein UL36; Provisional
 660-890 1.73e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 52.25  E-value: 1.73e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008519  660 PASSVLPTDRNLPTPTSAPTP-----GLAQGVHAPSTCSYMEATASSRARISRSISLGDSEGPIVATLAQPLRR--PSSV 732
Cdd:PHA03247 2613 PPSPLPPDTHAPDPPPPSPSPaanepDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRaaRPTV 2692

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008519  733 GELASLGQelqaittattPSLDSEGQEPALRSWgnhearanlrltlssaCDGLLQPPVDTQPGVTVPAVSF-PAPSPVEE 811
Cdd:PHA03247 2693 GSLTSLAD----------PPPPPPTPEPAPHAL----------------VSATPLPPGPAAARQASPALPAaPAPPAVPA 2746

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 768008519  812 SALRLHGSAFRPSLPAPESPGLPAHPSNPQLPEARPGIPGGTASLLEPTSGAlgllqgsPARWSEPWVPVEALPPSPLE 890
Cdd:PHA03247 2747 GPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESL-------PSPWDPADPPAAVLAPAAAL 2818
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 181-220 3.96e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 3.96e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 768008519    181 SGECIAKMFGHSEIITSMKFTYDCHHLITVSGDSCVFIWH 220
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PHA03247 PHA03247
large tegument protein UL36; Provisional
 593-893 3.18e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.40  E-value: 3.18e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008519  593 TFPPRATQCLVKSPEVKLMDRGGSQPRAGTGYASPDRTHVLAAGKAEETLEAW-RPPPPCLTSLASCVPASSVLPTDRNL 671
Cdd:PHA03247 2646 VPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLaDPPPPPPTPEPAPHALVSATPLPPGP 2725

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008519  672 -----------------PTPTSAPTPGLAQGVHAPSTCSYMEATASSRARIS---RSISLGDSEGPIVATLAQPLRRPSS 731
Cdd:PHA03247 2726 aaarqaspalpaapappAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAgppRRLTRPAVASLSESRESLPSPWDPA 2805

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008519  732 VGELASLGQELQAITTAT--TPSLDSEGQEPALRSWGNHEARANLRLTLSSACDGLLQPPVDTQPGVTVPA--------- 800
Cdd:PHA03247 2806 DPPAAVLAPAAALPPAASpaGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAaparppvrr 2885

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008519  801 VSFPAPSPVEES-ALRLHGSAFRPSLPAPESPGLPAHPSNPQLPEARPGIPGGTASLLEPTSGALGLLQGSPARwSEPWV 879
Cdd:PHA03247 2886 LARPAVSRSTESfALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAV-PQPWL 2964

                         330
                  ....*....|....
gi 768008519  880 PveALPPSPLELSR 893
Cdd:PHA03247 2965 G--ALVPGRVAVPR 2976
WD40 pfam00400
WD domain, G-beta repeat;
182-219 3.28e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 3.28e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 768008519   182 GECIAKMFGHSEIITSMKFTYDCHHLITVSGDSCVFIW 219
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PHA03247 PHA03247
large tegument protein UL36; Provisional
 545-889 3.92e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.01  E-value: 3.92e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008519  545 TESPCRELFPAALGDVEAS----------EAEDHFFNPRLSISTQFLSSLQKASRFTHTFPPRATQclvKSPEVKLMDRG 614
Cdd:PHA03247 2680 PQRPRRRAARPTVGSLTSLadpppppptpEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVP---AGPATPGGPAR 2756

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008519  615 GSQPRAGTGYASPDRTHVLAAGKAEetleawRPPPPCLTSLASCVPASSVLPTDRNLPTPTSAPTPGLAQ-----GVHAP 689
Cdd:PHA03247 2757 PARPPTTAGPPAPAPPAAPAAGPPR------RLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPaaspaGPLPP 2830

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008519  690 STCSYMEATASSRARISRSISLGDSEGPivatlAQPLRRPSSVGelaslgqelQAITTATTPSldsegqEPALRSWGnhe 769
Cdd:PHA03247 2831 PTSAQPTAPPPPPGPPPPSLPLGGSVAP-----GGDVRRRPPSR---------SPAAKPAAPA------RPPVRRLA--- 2887

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008519  770 aranlRLTLSSACDGLLQPPVDTQPGVTVPAVSFPAPSPVEESALRlhgsafrpSLPAPESPGLPAHPSNPQ-----LPE 844
Cdd:PHA03247 2888 -----RPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQ--------PQPPPPPPPRPQPPLAPTtdpagAGE 2954

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 768008519  845 ARPGIPGGTASLLEPTSGALGLLQGSPARwsePWVPVEALPPSPL 889
Cdd:PHA03247 2955 PSGAVPQPWLGALVPGRVAVPRFRVPQPA---PSREAPASSTPPL 2996
PHA03247 PHA03247
large tegument protein UL36; Provisional
 618-887 4.53e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 47.63  E-value: 4.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008519  618 PRAGTGYASPDRTHVLAAGKAE-ETLEAWRPPPPCltslascVPASSVLPTDRNLPTPTSAPT---PGLAQGVHAPSTcs 693
Cdd:PHA03247 2521 PDEPVGEPVHPRMLTWIRGLEElASDDAGDPPPPL-------PPAAPPAAPDRSVPPPRPAPRpsePAVTSRARRPDA-- 2591

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008519  694 ymeATASSRARISRSISlGDSEGPIVATLAQP----LRRPSSVGelASLGQELQAITTATTPSLDSEGQEPALRSWGNH- 768
Cdd:PHA03247 2592 ---PPQSARPRAPVDDR-GDPRGPAPPSPLPPdthaPDPPPPSP--SPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPr 2665

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008519  769 EARANLRLTLSSAcdgllqPPVDTQPGVTVPAVSF-------PAPSPVEESALRLHGSAFrPSLPAPES-----PGLPAH 836
Cdd:PHA03247 2666 RARRLGRAAQASS------PPQRPRRRAARPTVGSltsladpPPPPPTPEPAPHALVSAT-PLPPGPAAarqasPALPAA 2738

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 768008519  837 PSNPQLPEArPGIPGGTASLLEPTSGAlgllqgSPARWSEPWVPVEALPPS 887
Cdd:PHA03247 2739 PAPPAVPAG-PATPGGPARPARPPTTA------GPPAPAPPAAPAAGPPRR 2782
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 111-203 4.55e-05

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 43.04  E-value: 4.55e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008519   111 MDIditqkyVAVACQDRNVRVYNTvNGKqkKCYKGSQGDEGSLLK-VHVDPSGTFLATSCSDKSISVIDFYSGECIAKMF 189
Cdd:pfam12894    7 MDL------IALATEDGELLLHRL-NWQ--RVWTLSPDKEDLEVTsLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFS 77

                           90
                   ....*....|....
gi 768008519   190 GHSEIITSMKFTYD 203
Cdd:pfam12894   78 AGSDLITCLGWGEN 91
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 190-236 3.63e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 40.40  E-value: 3.63e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 768008519  190 GHSEIITSMKFTYDCHHLITVSGDSCVFIWHL-GPEITNCMKQHLLEI 236
Cdd:cd00200     7 GHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLeTGELLRTLKGHTGPV 54
PHA03379 PHA03379
EBNA-3A; Provisional
 783-889 4.45e-03

EBNA-3A; Provisional


Pssm-ID: 223066 [Multi-domain]  Cd Length: 935  Bit Score: 41.20  E-value: 4.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008519  783 DGLLQPPVDTQPGVT-VPAVSFPAPSPVEESALRLHGSAFRPSLPAPespgLPAHP-SNPQLPEARPGIPGGTASLLEPT 860
Cdd:PHA03379  482 DQLPGVVQDGRPACApVPAPAGPIVRPWEASLSQVPGVAFAPVMPQP----MPVEPvPVPTVALERPVCPAPPLIAMQGP 557

                          90       100
                  ....*....|....*....|....*....
gi 768008519  861 SGALGLLQGSPARWSEPWVPVEALPPSPL 889
Cdd:PHA03379  558 GETSGIVRVRERWRPAPWTPNPPRSPSQM 586
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 647-886 6.50e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.52  E-value: 6.50e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008519   647 PPPPCLTSLASCVPASSVlPTDRNLPTPTSAPTPGLAQGVHAPSTCSYMEATASSRARISRSISLGD--SEGPIVATLAQ 724
Cdd:pfam03154  186 PPPPGTTQAATAGPTPSA-PSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPSPHPPLQPmtQPPPPSQVSPQ 264

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008519   725 PLRRPSSVGELASLGQELQaittaTTPSLDSEGQEPALRSWGNHEARANLRLTLSSACDGLLQ-----PPVDTQPGVTVP 799
Cdd:pfam03154  265 PLPQPSLHGQMPPMPHSLQ-----TGPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQqrihtPPSQSQLQSQQP 339

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008519   800 AVSFP-APSPVEESALRLHGSAFRPSLPAPESPGLPAHPSNP---QLPEARPGIPG----GTASLLEPTSGALGLLQGSP 871
Cdd:pfam03154  340 PREQPlPPAPLSMPHIKPPPTTPIPQLPNPQSHKHPPHLSGPspfQMNSNLPPPPAlkplSSLSTHHPPSAHPPPLQLMP 419

                          250
                   ....*....|....*
gi 768008519   872 ArwSEPWVPVEALPP 886
Cdd:pfam03154  420 Q--SQQLPPPPAQPP 432
PHA03247 PHA03247
large tegument protein UL36; Provisional
 618-868 6.79e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 6.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008519  618 PRAGTGYASPDRTHVLAAGKAEETLEAWRPPPPCLTSLAS----CVPASSVLPTDRNLPTPTSAPTPGLAQGV------- 686
Cdd:PHA03247 2784 TRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASpagpLPPPTSAQPTAPPPPPGPPPPSLPLGGSVapggdvr 2863

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008519  687 -HAPSTCSYMEATASSRARISRsislgdsegpivatLAQP-LRRPSSVGELASLGQELQAITTATTPSLDSEGQEPALRS 764
Cdd:PHA03247 2864 rRPPSRSPAAKPAAPARPPVRR--------------LARPaVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQP 2929

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008519  765 WGNHEARANLRLTLSSACDGLLQPpvdtQPGVTVPAVSFPAPSPVEESALRLHGSAFRPSLPAPESpglpahPSNPQLPE 844
Cdd:PHA03247 2930 QPPPPPPPRPQPPLAPTTDPAGAG----EPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPAS------STPPLTGH 2999

                         250       260
                  ....*....|....*....|....*..
gi 768008519  845 ARPGIPGGTASL---LEPTSGALGLLQ 868
Cdd:PHA03247 3000 SLSRVSSWASSLalhEETDPPPVSLKQ 3026
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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