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Conserved domains on  [gi|768002018|ref|XP_011526236|]
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NACHT domain- and WD repeat-containing protein 1 isoform X4 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
419-763 1.73e-31

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 128.49  E-value: 1.73e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002018  419 GGPLRATLSGCHKGITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIFAKGTLANSASKDYTLHL 498
Cdd:COG2319    67 AGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRL 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002018  499 WNLLSGQekftiwdggsknpaEPQIWNLHVDEAHKVVYS------ASGS---KINAWNLETAEPVfHILGDASDPWMCMA 569
Cdd:COG2319   147 WDLATGK--------------LLRTLTGHSGAVTSVAFSpdgkllASGSddgTVRLWDLATGKLL-RTLTGHTGAVRSVA 211

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002018  570 VLASQATLLTVSRDGVVSLWSSATGKLQG--KQHMSSIKeetptcAVSVQKQGK-LVTGFSNGSISLVSSKGDRLLEKLP 646
Cdd:COG2319   212 FSPDGKLLASGSADGTVRLWDLATGKLLRtlTGHSGSVR------SVAFSPDGRlLASGSADGTVRLWDLATGELLRTLT 285

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002018  647 ---DAVRFLVVSEDESLLA-AGFGRSVRIF-LADSRGFRRFMAmdleHEDMVETAVFGTENNLIITGSLDALIQVWSLsE 721
Cdd:COG2319   286 ghsGGVNSVAFSPDGKLLAsGSDDGTVRLWdLATGKLLRTLTG----HTGAVRSVAFSPDGKTLASGSDDGTVRLWDL-A 360

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 768002018  722 QGTLLDILEGVGAPVSLLA--RGGALVASASpQSSSFKVWDLSD 763
Cdd:COG2319   361 TGELLRTLTGHTGAVTSVAfsPDGRTLASGS-ADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
640-1024 3.62e-23

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 103.45  E-value: 3.62e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002018  640 RLLEKLPDAVRFLVVSEDESLLAAGFGRSVRIFLADSRGFRRfmAMDLEHEDMVETAVFGTENNLIITGSLDALIQVWSL 719
Cdd:COG2319    30 LLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALL--ATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDL 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002018  720 SeQGTLLDILEGVGAPVSLLA--RGGALVASASpQSSSFKVWDLSDAHRSRVPAPFLDRTGLTAVSHNGSYVYFpkIGDK 797
Cdd:COG2319   108 A-TGLLLRTLTGHTGAVRSVAfsPDGKTLASGS-ADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLAS--GSDD 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002018  798 NKVTIWDLAEGEEQDSLD-TSSEIRCLEVAEQRKLLFTGLVSGVVLVFPLNSRQDVICIPPPEARkaINCMSLSKCEDRL 876
Cdd:COG2319   184 GTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGS--VRSVAFSPDGRLL 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002018  877 AIA-YDNIVLVLDITSGDPCPVIDGPrytfytqlPETLSSVAILTDYRVVYSMTN-GDLFLYECATSKAF-PLETHRSRV 953
Cdd:COG2319   262 ASGsADGTVRLWDLATGELLRTLTGH--------SGGVNSVAFSPDGKLLASGSDdGTVRLWDLATGKLLrTLTGHTGAV 333

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 768002018  954 ACVEVSHKEQLVVSGSEDALLCLWDLQARKWKFEMSYTSSycrGVQCACFSKDDKYVYVGLKDRSILVWSV 1024
Cdd:COG2319   334 RSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTG---AVTSVAFSPDGRTLASGSADGTVRLWDL 401
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
419-763 1.73e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 128.49  E-value: 1.73e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002018  419 GGPLRATLSGCHKGITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIFAKGTLANSASKDYTLHL 498
Cdd:COG2319    67 AGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRL 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002018  499 WNLLSGQekftiwdggsknpaEPQIWNLHVDEAHKVVYS------ASGS---KINAWNLETAEPVfHILGDASDPWMCMA 569
Cdd:COG2319   147 WDLATGK--------------LLRTLTGHSGAVTSVAFSpdgkllASGSddgTVRLWDLATGKLL-RTLTGHTGAVRSVA 211

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002018  570 VLASQATLLTVSRDGVVSLWSSATGKLQG--KQHMSSIKeetptcAVSVQKQGK-LVTGFSNGSISLVSSKGDRLLEKLP 646
Cdd:COG2319   212 FSPDGKLLASGSADGTVRLWDLATGKLLRtlTGHSGSVR------SVAFSPDGRlLASGSADGTVRLWDLATGELLRTLT 285

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002018  647 ---DAVRFLVVSEDESLLA-AGFGRSVRIF-LADSRGFRRFMAmdleHEDMVETAVFGTENNLIITGSLDALIQVWSLsE 721
Cdd:COG2319   286 ghsGGVNSVAFSPDGKLLAsGSDDGTVRLWdLATGKLLRTLTG----HTGAVRSVAFSPDGKTLASGSDDGTVRLWDL-A 360

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 768002018  722 QGTLLDILEGVGAPVSLLA--RGGALVASASpQSSSFKVWDLSD 763
Cdd:COG2319   361 TGELLRTLTGHTGAVTSVAfsPDGRTLASGS-ADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 422-718 1.54e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 122.44  E-value: 1.54e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002018  422 LRATLSGCHKGITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIFAKGTLANSASKDYTLHLWNL 501
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002018  502 LSGQEKFTIwdGGSKNPaepqIWNLHVDEAHKVVYSASGSK-INAWNLETAEPVFhILGDASDPWMCMAVLASQATLLTV 580
Cdd:cd00200    81 ETGECVRTL--TGHTSY----VSSVAFSPDGRILSSSSRDKtIKVWDVETGKCLT-TLRGHTDWVNSVAFSPDGTFVASS 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002018  581 SRDGVVSLWSSATGKLQG--KQHMSSIKeetpTCAVSvQKQGKLVTGFSNGSISLVSSKGDRLLEKLP---DAVRFLVVS 655
Cdd:cd00200   154 SQDGTIKLWDLRTGKCVAtlTGHTGEVN----SVAFS-PDGEKLLSSSSDGTIKLWDLSTGKCLGTLRgheNGVNSVAFS 228

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 768002018  656 EDESLLAAG-FGRSVRIFlaDSRGFRRfMAMDLEHEDMVETAVFGTENNLIITGSLDALIQVWS 718
Cdd:cd00200   229 PDGYLLASGsEDGTIRVW--DLRTGEC-VQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
640-1024 3.62e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 103.45  E-value: 3.62e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002018  640 RLLEKLPDAVRFLVVSEDESLLAAGFGRSVRIFLADSRGFRRfmAMDLEHEDMVETAVFGTENNLIITGSLDALIQVWSL 719
Cdd:COG2319    30 LLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALL--ATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDL 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002018  720 SeQGTLLDILEGVGAPVSLLA--RGGALVASASpQSSSFKVWDLSDAHRSRVPAPFLDRTGLTAVSHNGSYVYFpkIGDK 797
Cdd:COG2319   108 A-TGLLLRTLTGHTGAVRSVAfsPDGKTLASGS-ADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLAS--GSDD 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002018  798 NKVTIWDLAEGEEQDSLD-TSSEIRCLEVAEQRKLLFTGLVSGVVLVFPLNSRQDVICIPPPEARkaINCMSLSKCEDRL 876
Cdd:COG2319   184 GTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGS--VRSVAFSPDGRLL 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002018  877 AIA-YDNIVLVLDITSGDPCPVIDGPrytfytqlPETLSSVAILTDYRVVYSMTN-GDLFLYECATSKAF-PLETHRSRV 953
Cdd:COG2319   262 ASGsADGTVRLWDLATGELLRTLTGH--------SGGVNSVAFSPDGKLLASGSDdGTVRLWDLATGKLLrTLTGHTGAV 333

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 768002018  954 ACVEVSHKEQLVVSGSEDALLCLWDLQARKWKFEMSYTSSycrGVQCACFSKDDKYVYVGLKDRSILVWSV 1024
Cdd:COG2319   334 RSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTG---AVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 689-1023 2.00e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 81.23  E-value: 2.00e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002018  689 HEDMVETAVFGTENNLIITGSLDALIQVWSLsEQGTLLDILEGVGAPVSLLA--RGGALVASASpqsssfkvwdlsdahr 766
Cdd:cd00200     8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDL-ETGELLRTLKGHTGPVRDVAasADGTYLASGS---------------- 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002018  767 srvpapfLDRTgltavshngsyvyfpkigdknkVTIWDLAEGEEQDSLDT-SSEIRCLEVAEQRKLLFTGLVSGVVLVFP 845
Cdd:cd00200    71 -------SDKT----------------------IRLWDLETGECVRTLTGhTSYVSSVAFSPDGRILSSSSRDKTIKVWD 121

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002018  846 LNSRQDVICIPPPEArkAINCMSLSKCEDRLAIA-YDNIVLVLDITSGDPCPVIDGPRytfytqlpETLSSVAILTD-YR 923
Cdd:cd00200   122 VETGKCLTTLRGHTD--WVNSVAFSPDGTFVASSsQDGTIKLWDLRTGKCVATLTGHT--------GEVNSVAFSPDgEK 191

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002018  924 VVYSMTNGDLFLYECATSKAF-PLETHRSRVACVEVSHKEQLVVSGSEDALLCLWDLQARKWKFEMSYTSSycrGVQCAC 1002
Cdd:cd00200   192 LLSSSSDGTIKLWDLSTGKCLgTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTN---SVTSLA 268

                         330       340
                  ....*....|....*....|.
gi 768002018 1003 FSKDDKYVYVGLKDRSILVWS 1023
Cdd:cd00200   269 WSPDGKRLASGSADGTIRIWD 289
WD40 pfam00400
WD domain, G-beta repeat;
465-500 4.81e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.87  E-value: 4.81e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 768002018   465 IHMLTGHTGEVRCVKIFAKGTLANSASKDYTLHLWN 500
Cdd:pfam00400    4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 946-978 1.46e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 1.46e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 768002018    946 LETHRSRVACVEVSHKEQLVVSGSEDALLCLWD 978
Cdd:smart00320    8 LKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
946-978 1.91e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 1.91e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 768002018   946 LETHRSRVACVEVSHKEQLVVSGSEDALLCLWD 978
Cdd:pfam00400    7 LEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 463-500 2.18e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 2.18e-03
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 768002018    463 HVIHMLTGHTGEVRCVKIFAKGTLANSASKDYTLHLWN 500
Cdd:smart00320    3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
419-763 1.73e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 128.49  E-value: 1.73e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002018  419 GGPLRATLSGCHKGITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIFAKGTLANSASKDYTLHL 498
Cdd:COG2319    67 AGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRL 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002018  499 WNLLSGQekftiwdggsknpaEPQIWNLHVDEAHKVVYS------ASGS---KINAWNLETAEPVfHILGDASDPWMCMA 569
Cdd:COG2319   147 WDLATGK--------------LLRTLTGHSGAVTSVAFSpdgkllASGSddgTVRLWDLATGKLL-RTLTGHTGAVRSVA 211

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002018  570 VLASQATLLTVSRDGVVSLWSSATGKLQG--KQHMSSIKeetptcAVSVQKQGK-LVTGFSNGSISLVSSKGDRLLEKLP 646
Cdd:COG2319   212 FSPDGKLLASGSADGTVRLWDLATGKLLRtlTGHSGSVR------SVAFSPDGRlLASGSADGTVRLWDLATGELLRTLT 285

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002018  647 ---DAVRFLVVSEDESLLA-AGFGRSVRIF-LADSRGFRRFMAmdleHEDMVETAVFGTENNLIITGSLDALIQVWSLsE 721
Cdd:COG2319   286 ghsGGVNSVAFSPDGKLLAsGSDDGTVRLWdLATGKLLRTLTG----HTGAVRSVAFSPDGKTLASGSDDGTVRLWDL-A 360

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 768002018  722 QGTLLDILEGVGAPVSLLA--RGGALVASASpQSSSFKVWDLSD 763
Cdd:COG2319   361 TGELLRTLTGHTGAVTSVAfsPDGRTLASGS-ADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 422-718 1.54e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 122.44  E-value: 1.54e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002018  422 LRATLSGCHKGITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIFAKGTLANSASKDYTLHLWNL 501
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002018  502 LSGQEKFTIwdGGSKNPaepqIWNLHVDEAHKVVYSASGSK-INAWNLETAEPVFhILGDASDPWMCMAVLASQATLLTV 580
Cdd:cd00200    81 ETGECVRTL--TGHTSY----VSSVAFSPDGRILSSSSRDKtIKVWDVETGKCLT-TLRGHTDWVNSVAFSPDGTFVASS 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002018  581 SRDGVVSLWSSATGKLQG--KQHMSSIKeetpTCAVSvQKQGKLVTGFSNGSISLVSSKGDRLLEKLP---DAVRFLVVS 655
Cdd:cd00200   154 SQDGTIKLWDLRTGKCVAtlTGHTGEVN----SVAFS-PDGEKLLSSSSDGTIKLWDLSTGKCLGTLRgheNGVNSVAFS 228

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 768002018  656 EDESLLAAG-FGRSVRIFlaDSRGFRRfMAMDLEHEDMVETAVFGTENNLIITGSLDALIQVWS 718
Cdd:cd00200   229 PDGYLLASGsEDGTIRVW--DLRTGEC-VQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
419-806 9.15e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 120.02  E-value: 9.15e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002018  419 GGPLRATLSGCHKGITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIFAKGTLANSASKDYTLHL 498
Cdd:COG2319    25 LGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRL 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002018  499 WNLLSGQEKFTIWDggsknpaepqiwnlHVDEAHKVVYS------ASGS---KINAWNLETAEPVFHILGDASDPWmCMA 569
Cdd:COG2319   105 WDLATGLLLRTLTG--------------HTGAVRSVAFSpdgktlASGSadgTVRLWDLATGKLLRTLTGHSGAVT-SVA 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002018  570 VLASQATLLTVSRDGVVSLWSSATGKLQG--KQHMSSIKeetptcAVSVQKQGK-LVTGFSNGSISLVSSKGDRLLEKLP 646
Cdd:COG2319   170 FSPDGKLLASGSDDGTVRLWDLATGKLLRtlTGHTGAVR------SVAFSPDGKlLASGSADGTVRLWDLATGKLLRTLT 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002018  647 ---DAVRFLVVSEDESLLA-AGFGRSVRIFLADSRGFRRFMAmdlEHEDMVETAVFGTENNLIITGSLDALIQVWSLSEq 722
Cdd:COG2319   244 ghsGSVRSVAFSPDGRLLAsGSADGTVRLWDLATGELLRTLT---GHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLAT- 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002018  723 GTLLDILEGVGAPVSLLA--RGGALVASASpQSSSFKVWDLSDAHRSRVPAPFLDRTGLTAVSHNGSYVYFpkIGDKNKV 800
Cdd:COG2319   320 GKLLRTLTGHTGAVRSVAfsPDGKTLASGS-DDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLAS--GSADGTV 396


                  ....*.
gi 768002018  801 TIWDLA 806
Cdd:COG2319   397 RLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
640-1024 3.62e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 103.45  E-value: 3.62e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002018  640 RLLEKLPDAVRFLVVSEDESLLAAGFGRSVRIFLADSRGFRRfmAMDLEHEDMVETAVFGTENNLIITGSLDALIQVWSL 719
Cdd:COG2319    30 LLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALL--ATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDL 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002018  720 SeQGTLLDILEGVGAPVSLLA--RGGALVASASpQSSSFKVWDLSDAHRSRVPAPFLDRTGLTAVSHNGSYVYFpkIGDK 797
Cdd:COG2319   108 A-TGLLLRTLTGHTGAVRSVAfsPDGKTLASGS-ADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLAS--GSDD 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002018  798 NKVTIWDLAEGEEQDSLD-TSSEIRCLEVAEQRKLLFTGLVSGVVLVFPLNSRQDVICIPPPEARkaINCMSLSKCEDRL 876
Cdd:COG2319   184 GTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGS--VRSVAFSPDGRLL 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002018  877 AIA-YDNIVLVLDITSGDPCPVIDGPrytfytqlPETLSSVAILTDYRVVYSMTN-GDLFLYECATSKAF-PLETHRSRV 953
Cdd:COG2319   262 ASGsADGTVRLWDLATGELLRTLTGH--------SGGVNSVAFSPDGKLLASGSDdGTVRLWDLATGKLLrTLTGHTGAV 333

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 768002018  954 ACVEVSHKEQLVVSGSEDALLCLWDLQARKWKFEMSYTSSycrGVQCACFSKDDKYVYVGLKDRSILVWSV 1024
Cdd:COG2319   334 RSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTG---AVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
569-980 3.76e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 103.45  E-value: 3.76e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002018  569 AVLASQATLLTVSRDGVVSLWSSATGKLQGKQHMSSIKEETPTCAVSVQKQGKLVTGFSNGSISLVSSKGDRLLEKLPDA 648
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002018  649 VRFLVVSEDESLLA-AGFGRSVRIFLADSRGFRRFMAmdlEHEDMVETAVFGTENNLIITGSLDALIQVWSLsEQGTLLD 727
Cdd:COG2319    81 VLSVAFSPDGRLLAsASADGTVRLWDLATGLLLRTLT---GHTGAVRSVAFSPDGKTLASGSADGTVRLWDL-ATGKLLR 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002018  728 ILEGVGAPVSLLA--RGGALVASASpQSSSFKVWDLSDAHRSRVPAPFLDRTGLTAVSHNGSYVYFpkIGDKNKVTIWDL 805
Cdd:COG2319   157 TLTGHSGAVTSVAfsPDGKLLASGS-DDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLAS--GSADGTVRLWDL 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002018  806 AEGEEQDSLDT-SSEIRCLEVAEQRKLLFTGLVSGVVLVFPLNSRQDVICIPPPEARkaINCMSLSKCEDRLAIA-YDNI 883
Cdd:COG2319   234 ATGKLLRTLTGhSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGG--VNSVAFSPDGKLLASGsDDGT 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002018  884 VLVLDITSGDPCPVIDGPRYTFYtqlpetlsSVAILTD-YRVVYSMTNGDLFLYECATSKAF-PLETHRSRVACVEVSHK 961
Cdd:COG2319   312 VRLWDLATGKLLRTLTGHTGAVR--------SVAFSPDgKTLASGSDDGTVRLWDLATGELLrTLTGHTGAVTSVAFSPD 383

                         410
                  ....*....|....*....
gi 768002018  962 EQLVVSGSEDALLCLWDLQ 980
Cdd:COG2319   384 GRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
653-1036 7.83e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 99.22  E-value: 7.83e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002018  653 VVSEDESLLAAGFGRSVRIFLADSRGFRRFMAmdLEHEDMVETAVFGTENNLIITGSLDALIQVWsLSEQGTLLDILEGV 732
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALLLLL--LGLAAAVASLAASPDGARLAAGAGDLTLLLL-DAAAGALLATLLGH 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002018  733 GAPVSLLA--RGGALVASASPQSSsFKVWDLSDAHRSRVPAPFLDRTGLTAVSHNGSYVYFpkIGDKNKVTIWDLAEGEE 810
Cdd:COG2319    78 TAAVLSVAfsPDGRLLASASADGT-VRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLAS--GSADGTVRLWDLATGKL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002018  811 QDSLDT-SSEIRCLEVAEQRKLLFTGLVSGVVLVFPLNSRQDVICIPPPEARkaINCMSLSKCEDRLAIA-YDNIVLVLD 888
Cdd:COG2319   155 LRTLTGhSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGA--VRSVAFSPDGKLLASGsADGTVRLWD 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002018  889 ITSGDPCPVIDGPRYTFYtqlpetlsSVAILTD-YRVVYSMTNGDLFLYECATSKA-FPLETHRSRVACVEVSHKEQLVV 966
Cdd:COG2319   233 LATGKLLRTLTGHSGSVR--------SVAFSPDgRLLASGSADGTVRLWDLATGELlRTLTGHSGGVNSVAFSPDGKLLA 304

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002018  967 SGSEDALLCLWDLQARKWKFEMSytsSYCRGVQCACFSKDDKYVYVGLKDRSILVWSVLDGTLLTVQFVH 1036
Cdd:COG2319   305 SGSDDGTVRLWDLATGKLLRTLT---GHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGH 371
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 420-590 2.55e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 86.62  E-value: 2.55e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002018  420 GPLRATLSGCHKGITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIFAKGTLANSASKDYTLHLW 499
Cdd:cd00200   125 GKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLW 204

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002018  500 NLLSGQEKFTIWdgGSKNPaepqIWNLHVDEAHKVVYSASG-SKINAWNLETAEPVFHILGDASDPWmCMAVLASQATLL 578
Cdd:cd00200   205 DLSTGKCLGTLR--GHENG----VNSVAFSPDGYLLASGSEdGTIRVWDLRTGECVQTLSGHTNSVT-SLAWSPDGKRLA 277

                         170
                  ....*....|..
gi 768002018  579 TVSRDGVVSLWS 590
Cdd:cd00200   278 SGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 689-1023 2.00e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 81.23  E-value: 2.00e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002018  689 HEDMVETAVFGTENNLIITGSLDALIQVWSLsEQGTLLDILEGVGAPVSLLA--RGGALVASASpqsssfkvwdlsdahr 766
Cdd:cd00200     8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDL-ETGELLRTLKGHTGPVRDVAasADGTYLASGS---------------- 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002018  767 srvpapfLDRTgltavshngsyvyfpkigdknkVTIWDLAEGEEQDSLDT-SSEIRCLEVAEQRKLLFTGLVSGVVLVFP 845
Cdd:cd00200    71 -------SDKT----------------------IRLWDLETGECVRTLTGhTSYVSSVAFSPDGRILSSSSRDKTIKVWD 121

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002018  846 LNSRQDVICIPPPEArkAINCMSLSKCEDRLAIA-YDNIVLVLDITSGDPCPVIDGPRytfytqlpETLSSVAILTD-YR 923
Cdd:cd00200   122 VETGKCLTTLRGHTD--WVNSVAFSPDGTFVASSsQDGTIKLWDLRTGKCVATLTGHT--------GEVNSVAFSPDgEK 191

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002018  924 VVYSMTNGDLFLYECATSKAF-PLETHRSRVACVEVSHKEQLVVSGSEDALLCLWDLQARKWKFEMSYTSSycrGVQCAC 1002
Cdd:cd00200   192 LLSSSSDGTIKLWDLSTGKCLgTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTN---SVTSLA 268

                         330       340
                  ....*....|....*....|.
gi 768002018 1003 FSKDDKYVYVGLKDRSILVWS 1023
Cdd:cd00200   269 WSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 817-1036 1.31e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 66.59  E-value: 1.31e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002018  817 SSEIRCLEVAEQRKLLFTGLVSGVVLVFPLNSRQDVICIPppEARKAINCMSLSKCEDRLAIA-YDNIVLVLDITSGDPC 895
Cdd:cd00200     9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLK--GHTGPVRDVAASADGTYLASGsSDKTIRLWDLETGECV 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002018  896 pvidgprYTFyTQLPETLSSVAILTDYRVVY-SMTNGDLFLYECATSKA-FPLETHRSRVACVEVSHKEQLVVSGSEDAL 973
Cdd:cd00200    87 -------RTL-TGHTSYVSSVAFSPDGRILSsSSRDKTIKVWDVETGKClTTLRGHTDWVNSVAFSPDGTFVASSSQDGT 158

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 768002018  974 LCLWDLqaRKWKFEMSYTSSYcRGVQCACFSKDDKYVYVGLKDRSILVWSVLDGTLLTVQFVH 1036
Cdd:cd00200   159 IKLWDL--RTGKCVATLTGHT-GEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGH 218
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 419-631 4.60e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 61.97  E-value: 4.60e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002018  419 GGPLRATLSGcHKG-ITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIFAKGTLANSASKDYTLH 497
Cdd:cd00200    82 TGECVRTLTG-HTSyVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002018  498 LWNLLSGQEKFTIwdGGSKNPaepqIWNLHVDEAHKVVYSASGSK-INAWNLETAEPVfHILGDASDPWMCMAVLASQAT 576
Cdd:cd00200   161 LWDLRTGKCVATL--TGHTGE----VNSVAFSPDGEKLLSSSSDGtIKLWDLSTGKCL-GTLRGHENGVNSVAFSPDGYL 233

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 768002018  577 LLTVSRDGVVSLWSSATGKLqgkqhMSSIKEETPTC-AVSVQKQGK-LVTGFSNGSI 631
Cdd:cd00200   234 LASGSEDGTIRVWDLRTGEC-----VQTLSGHTNSVtSLAWSPDGKrLASGSADGTI 285
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 417-500 3.20e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 59.27  E-value: 3.20e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002018  417 PPGGPLRATLSGCHKGITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIFAKGTLANSASKDYTL 496
Cdd:cd00200   206 LSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTI 285


                  ....
gi 768002018  497 HLWN 500
Cdd:cd00200   286 RIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 946-1051 1.00e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 51.95  E-value: 1.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002018  946 LETHRSRVACVEVSHKEQLVVSGSEDALLCLWDLQarkwKFEMSYT-SSYCRGVQCACFSKDDKYVYVGLKDRSILVWSV 1024
Cdd:cd00200    47 LKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE----TGECVRTlTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV 122

                          90       100
                  ....*....|....*....|....*....
gi 768002018 1025 LDGTLLTVQFVH--AVVNRIIPTTSGFIA 1051
Cdd:cd00200   123 ETGKCLTTLRGHtdWVNSVAFSPDGTFVA 151
WD40 pfam00400
WD domain, G-beta repeat;
465-500 4.81e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.87  E-value: 4.81e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 768002018   465 IHMLTGHTGEVRCVKIFAKGTLANSASKDYTLHLWN 500
Cdd:pfam00400    4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 946-978 1.46e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 1.46e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 768002018    946 LETHRSRVACVEVSHKEQLVVSGSEDALLCLWD 978
Cdd:smart00320    8 LKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
946-978 1.91e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 1.91e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 768002018   946 LETHRSRVACVEVSHKEQLVVSGSEDALLCLWD 978
Cdd:pfam00400    7 LEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 463-500 2.18e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 2.18e-03
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 768002018    463 HVIHMLTGHTGEVRCVKIFAKGTLANSASKDYTLHLWN 500
Cdd:smart00320    3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 425-478 5.83e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 37.26  E-value: 5.83e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 768002018   425 TLSGCHKG--ITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCV 478
Cdd:pfam12894   31 TLSPDKEDleVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCL 86
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 858-985 7.37e-03

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 39.90  E-value: 7.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002018  858 PEARKAINCMSLS--KCEDRLAIAY-DNIVLVLDITSGDPCPVIDGPRYTFYTQLPETLSSVAILTdyRVVYSMT-NGDL 933
Cdd:cd22857    27 PDKSKAVQALSIAdrESEPLLAVARkNGTVEVLDPENGDLLASFSDSEPATKLSEEDHFVGLHLFS--GTLLTCTsKGSL 104

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 768002018  934 FLY-----ECATSKAFPLETHRSRVACVEVSHKEQLVVSGSEDALLCLWDLQ---ARKWK 985
Cdd:cd22857   105 RSTklpddSTASSSPTAWVCLGGNLLCMRVDPNENYFAFGGKEVELNVWDLEekpGKIWR 164
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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