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Conserved domains on  [gi|768004286|ref|XP_011526643|]
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deoxyhypusine hydroxylase isoform X1 [Homo sapiens]

Protein Classification

HEAT repeat domain-containing protein( domain architecture ID 11444215)

HEAT repeat domain-containing protein similar to Homo sapiens deoxyhypusine hydroxylase (DOHH), which catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor

CATH:  1.25.10.10
Gene Ontology:  GO:0005515
PubMed:  10378263
SCOP:  4001283

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HEAT COG1413
HEAT repeat [General function prediction only];
7-114 1.89e-15

HEAT repeat [General function prediction only];


:

Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 68.89  E-value: 1.89e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004286   7 VDAIGQTLVDPKQplQARFRALFTLRGLGGPGAIAWISQAFDDDSALLKHELAYCLGQMQDARAIPMLVDVLQDTrqEPM 86
Cdd:COG1413   18 VPALIAALADEDP--DVRAAAARALGRLGDPRAVPALLEALKDPDPEVRAAAAEALGRIGDPEAVPALIAALKDE--DPE 93

                         90       100
                 ....*....|....*....|....*...
gi 768004286  87 VRHEAGEALGAIGDPEVLEILKQYSSDP 114
Cdd:COG1413   94 VRRAAAEALGRLGDPAAVPALLEALKDP 121
 
Name Accession Description Interval E-value
HEAT COG1413
HEAT repeat [General function prediction only];
7-114 1.89e-15

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 68.89  E-value: 1.89e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004286   7 VDAIGQTLVDPKQplQARFRALFTLRGLGGPGAIAWISQAFDDDSALLKHELAYCLGQMQDARAIPMLVDVLQDTrqEPM 86
Cdd:COG1413   18 VPALIAALADEDP--DVRAAAARALGRLGDPRAVPALLEALKDPDPEVRAAAAEALGRIGDPEAVPALIAALKDE--DPE 93

                         90       100
                 ....*....|....*....|....*...
gi 768004286  87 VRHEAGEALGAIGDPEVLEILKQYSSDP 114
Cdd:COG1413   94 VRRAAAEALGRLGDPAAVPALLEALKDP 121
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 41-135 7.71e-12

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 58.12  E-value: 7.71e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004286   41 AWISQAFDDDSALLKHELAYCLGQMQDARAIPMLVDVLQDtrQEPMVRHEAGEALGAIGDPEVLEILKqyssdpviegDH 120
Cdd:pfam13646   3 ALLQALLRDPDPEVRAAAIRALGRIGDPEAVPALLELLKD--EDPAVRRAAAEALGKIGDPEALPALL----------EL 70

                          90
                  ....*....|....*
gi 768004286  121 LAKDAPGMRKARATI 135
Cdd:pfam13646  71 LRDDDDDVVRAAAAE 85
EZ_HEAT smart00567
E-Z type HEAT repeats; Present in subunits of cyanobacterial phycocyanin lyase, and other ...
 85-114 6.89e-07

E-Z type HEAT repeats; Present in subunits of cyanobacterial phycocyanin lyase, and other proteins. Probable scaffolding role.


Pssm-ID: 128837 [Multi-domain]  Cd Length: 30  Bit Score: 43.56  E-value: 6.89e-07
                           10        20        30
                   ....*....|....*....|....*....|
gi 768004286    85 PMVRHEAGEALGAIGDPEVLEILKQYSSDP 114
Cdd:smart00567   1 PLVRHEAAFALGQLGDEEAVPALIKALEDE 30
 
Name Accession Description Interval E-value
HEAT COG1413
HEAT repeat [General function prediction only];
7-114 1.89e-15

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 68.89  E-value: 1.89e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004286   7 VDAIGQTLVDPKQplQARFRALFTLRGLGGPGAIAWISQAFDDDSALLKHELAYCLGQMQDARAIPMLVDVLQDTrqEPM 86
Cdd:COG1413   18 VPALIAALADEDP--DVRAAAARALGRLGDPRAVPALLEALKDPDPEVRAAAAEALGRIGDPEAVPALIAALKDE--DPE 93

                         90       100
                 ....*....|....*....|....*...
gi 768004286  87 VRHEAGEALGAIGDPEVLEILKQYSSDP 114
Cdd:COG1413   94 VRRAAAEALGRLGDPAAVPALLEALKDP 121
HEAT COG1413
HEAT repeat [General function prediction only];
24-114 6.28e-15

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 67.35  E-value: 6.28e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004286  24 RFRALFTLRGLGGPGAIAWISQAFDDDSALLKHELAYCLGQMQDARAIPMLVDVLQDTrqEPMVRHEAGEALGAIGDPEV 103
Cdd:COG1413    2 RRAAARALGRLGDPAAVPALIAALADEDPDVRAAAARALGRLGDPRAVPALLEALKDP--DPEVRAAAAEALGRIGDPEA 79

                         90
                 ....*....|.
gi 768004286 104 LEILKQYSSDP 114
Cdd:COG1413   80 VPALIAALKDE 90
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 41-135 7.71e-12

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 58.12  E-value: 7.71e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004286   41 AWISQAFDDDSALLKHELAYCLGQMQDARAIPMLVDVLQDtrQEPMVRHEAGEALGAIGDPEVLEILKqyssdpviegDH 120
Cdd:pfam13646   3 ALLQALLRDPDPEVRAAAIRALGRIGDPEAVPALLELLKD--EDPAVRRAAAEALGKIGDPEALPALL----------EL 70

                          90
                  ....*....|....*
gi 768004286  121 LAKDAPGMRKARATI 135
Cdd:pfam13646  71 LRDDDDDVVRAAAAE 85
HEAT COG1413
HEAT repeat [General function prediction only];
22-99 8.54e-10

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 53.86  E-value: 8.54e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 768004286  22 QARFRALFTLRGLGGPGAIAWISQAFDDDSALLKHELAYCLGQMQDARAIPMLVDVLQDtrQEPMVRHEAGEALGAIG 99
Cdd:COG1413   62 EVRAAAAEALGRIGDPEAVPALIAALKDEDPEVRRAAAEALGRLGDPAAVPALLEALKD--PDWEVRRAAARALGRLG 137
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 24-96 1.53e-08

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 49.26  E-value: 1.53e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 768004286   24 RFRALFTLRGLGGPGAIAWISQAFDDDSALLKHELAYCLGQMQDARAIPMLVDVLQDTrQEPMVRHEAGEALG 96
Cdd:pfam13646  17 RAAAIRALGRIGDPEAVPALLELLKDEDPAVRRAAAEALGKIGDPEALPALLELLRDD-DDDVVRAAAAEALA 88
EZ_HEAT smart00567
E-Z type HEAT repeats; Present in subunits of cyanobacterial phycocyanin lyase, and other ...
 85-114 6.89e-07

E-Z type HEAT repeats; Present in subunits of cyanobacterial phycocyanin lyase, and other proteins. Probable scaffolding role.


Pssm-ID: 128837 [Multi-domain]  Cd Length: 30  Bit Score: 43.56  E-value: 6.89e-07
                           10        20        30
                   ....*....|....*....|....*....|
gi 768004286    85 PMVRHEAGEALGAIGDPEVLEILKQYSSDP 114
Cdd:smart00567   1 PLVRHEAAFALGQLGDEEAVPALIKALEDE 30
EZ_HEAT smart00567
E-Z type HEAT repeats; Present in subunits of cyanobacterial phycocyanin lyase, and other ...
 52-81 1.90e-05

E-Z type HEAT repeats; Present in subunits of cyanobacterial phycocyanin lyase, and other proteins. Probable scaffolding role.


Pssm-ID: 128837 [Multi-domain]  Cd Length: 30  Bit Score: 39.71  E-value: 1.90e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 768004286    52 ALLKHELAYCLGQMQDARAIPMLVDVLQDT 81
Cdd:smart00567   1 PLVRHEAAFALGQLGDEEAVPALIKALEDE 30
HEAT_PBS pfam03130
PBS lyase HEAT-like repeat; This family contains a short bi-helical repeat that is related to ...
 87-113 9.19e-04

PBS lyase HEAT-like repeat; This family contains a short bi-helical repeat that is related to pfam02985. Cyanobacteria and red algae harvest light energy using macromolecular complexes known as phycobilisomes (PBS), peripherally attached to the photosynthetic membrane. The major components of PBS are the phycobiliproteins. These heterodimeric proteins are covalently attached to phycobilins: open-chain tetrapyrrole chromophores, which function as the photosynthetic light-harvesting pigments. Phycobiliproteins differ in sequence and in the nature and number of attached phycobilins to each of their subunits. This family includes the lyase enzymes that specifically attach particular phycobilins to apophycobiliprotein subunits. The most comprehensively studied of these is the CpcE/F lyase, which attaches phycocyanobilin (PCB) to the alpha subunit of apophycocyanin. Similarly, MpeU/V attaches phycoerythrobilin to phycoerythrin II, while CpeY/Z is thought to be involved in phycoerythrobilin (PEB) attachment to phycoerythrin (PE) I (PEs I and II differ in sequence and in the number of attached molecules of PEB: PE I has five, PE II has six). All the reactions of the above lyases involve an apoprotein cysteine SH addition to a terminal delta 3,3'-double bond. Such a reaction is not possible in the case of phycoviolobilin (PVB), the phycobilin of alpha-phycoerythrocyanin (alpha-PEC). It is thought that in this case, PCB, not PVB, is first added to apo-alpha-PEC, and is then isomerized to PVB. The addition reaction has been shown to occur in the presence of either of the components of alpha-PEC-PVB lyase PecE or PecF (or both). The isomerization reaction occurs only when both PecE and PecF components are present, i.e. the PecE/F phycobiliprotein lyase is also a phycobilin isomerase. Another member of this family is the NblB protein, whose similarity to the phycobiliprotein lyases was previously noted. This constitutively expressed protein is not known to have any lyase activity. It is thought to be involved in the coordination of PBS degradation with environmental nutrient limitation. It has been suggested that the similarity of NblB to the phycobiliprotein lyases is due to the ability to bind tetrapyrrole phycobilins via the common repeated motif.


Pssm-ID: 308641 [Multi-domain]  Cd Length: 27  Bit Score: 35.15  E-value: 9.19e-04
                          10        20
                  ....*....|....*....|....*..
gi 768004286   87 VRHEAGEALGAIGDPEVLEILKQYSSD 113
Cdd:pfam03130   1 VRRAAARALGALGDPEAIPALIEALDD 27
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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