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Conserved domains on  [gi|768018403|ref|XP_011527366|]
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solute carrier family 2, facilitated glucose transporter member 10 isoform X7 [Homo sapiens]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
31-337 1.30e-142

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17436:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 376  Bit Score: 414.58  E-value: 1.30e-142
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  31 LCASVSLLGGLTFGYELAVISGALLPLQLDFGLSCLEQEFLVGSLLLGALLASLVGGFLIDCYGRKQAILGSNLVLLAGS 110
Cdd:cd17436    1 LTATVSLLGGLTFGYELGIISGALLQLQTDFSLSCFEQEALVSALLIGALLASLIGGFLIDRHGRRTSILGSNLVLLAGS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 111 LTLGLAGSLAWLVLGRAVVGFAISLSSMACCIYVSELVGPRQRGVLVSLYEAGITVGILLSYALNYALAGTPWGWRHMFG 190
Cdd:cd17436   81 LILTLAGSFFWLVIGRAVVGFAISVSSMACCIYVSEMVTPHQRGLLVSLYEAGITVGILISYALNYFFSNVLTGWRYMFG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 191 WATAPAVLQSLSLLFLPAGTDETAThkdliplqggeapklgpgrprysfldlfraRDNMRGRTTVGLGLVLFQQLTGQPN 270
Cdd:cd17436  161 LAIIPAAIQFASILLLPKKPEVLNI------------------------------KDNMRRRTLVGLGLVLFQQFTGQPN 210
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 768018403 271 VLCYASTIFSSVGFHGGSSAVLASVGLGAVKVAATLTAMGLVDRAGRRALLLAGCALMALSVSGIGL 337
Cdd:cd17436  211 VLCYASTIFRSVGFQSNSSAVLASVGLGVVKVIATLLAMLFADRAGRRSLLIAGCSVMAVSVSGIGL 277
 
Name Accession Description Interval E-value
MFS_GLUT10_Class3 cd17436
Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of ...
31-337 1.30e-142

Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 10 (GLUT10) is also called Solute carrier family 2, facilitated glucose transporter member 10 (SLC2A10). It is classified as a Class 3 GLUT and is a facilitative glucose transporter that exhibits a wide tissue distribution. It is expressed in pancreas, placenta, heart, lung, liver, brain, fat, muscle, and kidney. GLUT10 facilitates the transport of dehydroascorbic acid (DHA), the oxidized form of vitamin C, into mitochondria, and also increases cellular uptake of DHA, which in turn protects cells against oxidative stress. Loss-of-function mutations in SLC2A10 cause arterial tortuosity syndrome (ATS), an autosomal recessive connective tissue disorder characterized by twisting and lengthening of the major arteries, hypermobility of the joints, and laxity of skin. The GLUT10 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340994 [Multi-domain]  Cd Length: 376  Bit Score: 414.58  E-value: 1.30e-142
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  31 LCASVSLLGGLTFGYELAVISGALLPLQLDFGLSCLEQEFLVGSLLLGALLASLVGGFLIDCYGRKQAILGSNLVLLAGS 110
Cdd:cd17436    1 LTATVSLLGGLTFGYELGIISGALLQLQTDFSLSCFEQEALVSALLIGALLASLIGGFLIDRHGRRTSILGSNLVLLAGS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 111 LTLGLAGSLAWLVLGRAVVGFAISLSSMACCIYVSELVGPRQRGVLVSLYEAGITVGILLSYALNYALAGTPWGWRHMFG 190
Cdd:cd17436   81 LILTLAGSFFWLVIGRAVVGFAISVSSMACCIYVSEMVTPHQRGLLVSLYEAGITVGILISYALNYFFSNVLTGWRYMFG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 191 WATAPAVLQSLSLLFLPAGTDETAThkdliplqggeapklgpgrprysfldlfraRDNMRGRTTVGLGLVLFQQLTGQPN 270
Cdd:cd17436  161 LAIIPAAIQFASILLLPKKPEVLNI------------------------------KDNMRRRTLVGLGLVLFQQFTGQPN 210
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 768018403 271 VLCYASTIFSSVGFHGGSSAVLASVGLGAVKVAATLTAMGLVDRAGRRALLLAGCALMALSVSGIGL 337
Cdd:cd17436  211 VLCYASTIFRSVGFQSNSSAVLASVGLGVVKVIATLLAMLFADRAGRRSLLIAGCSVMAVSVSGIGL 277
Sugar_tr pfam00083
Sugar (and other) transporter;
32-343 4.51e-45

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 163.98  E-value: 4.51e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403   32 CASVSLLGGLTFGYELAVISGALLPLQ--LDFGLSCLEQEFLVGSLLLGALLASLV---------GGFLIDCYGRKQAIL 100
Cdd:pfam00083   1 VALVAALGGFLFGYDTGVIGAFLTLIDffKNFGLSKSVSSLAALSVLSGLIVSIFSvgcfigslfAGKLGDRFGRKKSLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  101 GSNLVLLAGSLTLGLA---GSLAWLVLGRAVVGFAISLSSMACCIYVSELVGPRQRGVLVSLYEAGITVGILLSYALNYA 177
Cdd:pfam00083  81 IANVLFVIGAVLQGAAkgkWSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGLG 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  178 LA--GTPWGWRHMFGWATAPAVLQSLSLLFLP--------AGTDETAThKDLIPLQGGEAPKL-----------GPGRPR 236
Cdd:pfam00083 161 LNktSNSDGWRIPLGLQLVPALLLIIGLLFLPesprwlveKGRLEEAR-EVLAKLRGVPDVDReldeikdsleaGQEAEK 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  237 YSFLDLFRARdNMRGRTTVGLGLVLFQQLTGQPNVLCYASTIFSSVGFhggSSAVLASVGLGAVKVAATLTAMGLVDRAG 316
Cdd:pfam00083 240 ASWKELFSTK-TRRQRLLIGVMLQIFQQLTGINAIFYYSTTIFENLGL---SDSFLVTIIVGVVNFVFTFIAIFLVDRFG 315
                         330       340
                  ....*....|....*....|....*..
gi 768018403  317 RRALLLAGCALMALSVSGIGLVSFAVP 343
Cdd:pfam00083 316 RRPLLLLGAAGMAICFVILGIVALLGV 342
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
25-340 9.56e-45

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 164.05  E-value: 9.56e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403   25 SPPVLPLCASVSLlGGLTFGYELAVISGAL--------LPLQLDFGLSCLEQEFLVGSLLLGALLASLVGGFLIDCYGRK 96
Cdd:TIGR00879  23 YWKVALLSLIAAI-GGLMFGYDTGVIGGALalpafefkFTSANSDSYSSSLWGLVVSIFLVGGFIGALFAGWLSDRFGRK 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403   97 QAILGSNLVLLAGSLTLGLAG---SLAWLVLGRAVVGFAISLSSMACCIYVSELVGPRQRGVLVSLYEAGITVGILLSYA 173
Cdd:TIGR00879 102 KSLLIIALLFVIGAILMGLAAfalSVEMLIVGRVLLGIGVGIASALVPMYLSEIAPKALRGALTSLYQLAITFGILVAYG 181
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  174 LNYA--LAGTPWGWRHMFGWATAPAVLQSLSLLFLPA--------GTDETAThKDLIPLQGGEAP--------------- 228
Cdd:TIGR00879 182 FGSGkvSLNNTLGWRIPLGLQLIPAGLLFLGLFFLPEsprwlvgkGRVEEAR-KSLARLRGTSGEdkelldelelidikr 260
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  229 KLGPGRPRYSFLDLFRARDNMRGRTTVGLGLVLFQQLTGQPNVLCYASTIFSSVGFhGGSSAVLASVGLGAVKVAATLTA 308
Cdd:TIGR00879 261 SIEKRSVQPSWGSLFSSTRRIRRRLFLGVVLQWFQQFTGINAIMYYSPTIFENAGV-STDHAFLVSIIVGAVNFAFTFVA 339
                         330       340       350
                  ....*....|....*....|....*....|..
gi 768018403  309 MGLVDRAGRRALLLAGCALMALSVSGIGLVSF 340
Cdd:TIGR00879 340 IFLVDRFGRRPLLLIGAAGMAICLFVLGILGA 371
xylE PRK10077
D-xylose transporter XylE; Provisional
33-341 3.47e-31

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 125.96  E-value: 3.47e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  33 ASVSLLGGLTFGYELAVISGA--------LLPLQLDFGLSCLEQEFLVGSLLLGALLASLVGGFLIDCYGRKQA-ILGSN 103
Cdd:PRK10077  14 TLVATLGGLLFGYDTAVISGTveslntvfVAPQNLSESAANSLLGFCVASALIGCIIGGALGGYCSNRFGRRDSlKIAAV 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 104 LVLLAGsltLGLA-----------GSLAWL---VLGRAVVGFAISLSSMACCIYVSELVGPRQRGVLVSLYEAGITVGIL 169
Cdd:PRK10077  94 LFFISA---LGSAwpefgftsigpDNTGYVpefVIYRIIGGIGVGLASMLSPMYIAEIAPAHIRGKLVSFNQFAIIFGQL 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 170 LSYALNYALAGTP---W----GWRHMFGWATAPAVLQSLSLLFLPagtdET-----ATHKD------LIPLQGGEAPK-- 229
Cdd:PRK10077 171 VVYFVNYFIARSGdasWlntdGWRYMFASEAIPALLFLMLLYFVP----ETprylmSRGKQeqaegiLRKIMGNTLATqa 246
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 230 -------LGPGRPRYSFLDLFRArdnmrGRTTVGLGLVLFQQLTGQPNVLCYASTIFSSVGFhGGSSAVLASVGLGAVKV 302
Cdd:PRK10077 247 lqeikhsLDHGRKTGGKLLMFGV-----GVIVIGVMLSVFQQFVGINVVLYYAPEIFKTLGA-STDIALLQTIIVGVINL 320
                        330       340       350
                 ....*....|....*....|....*....|....*....
gi 768018403 303 AATLTAMGLVDRAGRRALLLAGCALMALSVSGIGLVSFA 341
Cdd:PRK10077 321 TFTVLAIMTVDKFGRKPLQIIGALGMAIGMFSLGTAFYT 359
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
37-344 3.49e-23

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 100.43  E-value: 3.49e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  37 LLGGLTFGYELAVISGALLPLQLDFGLSCLEQEFLVGSLLLGALLASLVGGFLIDCYGRKQAILGSNLVLLAGSLTLGLA 116
Cdd:COG2814   16 ALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALA 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 117 GSLAWLVLGRAVVGFAISLSSMACCIYVSELVGPRQRGVLVSLYEAGITVGILLSYALNYALAGTpWGWRHMFGWATAPA 196
Cdd:COG2814   96 PSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADL-FGWRWVFLVNAVLA 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 197 VLQSLSLLFlpagtdetathkdLIPlqggEAPKLGPGRPRYSFLDLFRArdnmrgRTTVGLGLVLFQQLTGQPNVLCYAS 276
Cdd:COG2814  175 LLALLLLLR-------------LLP----ESRPAARARLRGSLRELLRR------PRLLLLLLLAFLLGFGFFALFTYLP 231
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 768018403 277 TIFSSVGFHGGSSAVLASVGLGAVKVAATLTAMGLVDRAGRRALLLAGCALMALSVSGIGLVSFAVPM 344
Cdd:COG2814  232 LYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLL 299
 
Name Accession Description Interval E-value
MFS_GLUT10_Class3 cd17436
Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of ...
31-337 1.30e-142

Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 10 (GLUT10) is also called Solute carrier family 2, facilitated glucose transporter member 10 (SLC2A10). It is classified as a Class 3 GLUT and is a facilitative glucose transporter that exhibits a wide tissue distribution. It is expressed in pancreas, placenta, heart, lung, liver, brain, fat, muscle, and kidney. GLUT10 facilitates the transport of dehydroascorbic acid (DHA), the oxidized form of vitamin C, into mitochondria, and also increases cellular uptake of DHA, which in turn protects cells against oxidative stress. Loss-of-function mutations in SLC2A10 cause arterial tortuosity syndrome (ATS), an autosomal recessive connective tissue disorder characterized by twisting and lengthening of the major arteries, hypermobility of the joints, and laxity of skin. The GLUT10 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340994 [Multi-domain]  Cd Length: 376  Bit Score: 414.58  E-value: 1.30e-142
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  31 LCASVSLLGGLTFGYELAVISGALLPLQLDFGLSCLEQEFLVGSLLLGALLASLVGGFLIDCYGRKQAILGSNLVLLAGS 110
Cdd:cd17436    1 LTATVSLLGGLTFGYELGIISGALLQLQTDFSLSCFEQEALVSALLIGALLASLIGGFLIDRHGRRTSILGSNLVLLAGS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 111 LTLGLAGSLAWLVLGRAVVGFAISLSSMACCIYVSELVGPRQRGVLVSLYEAGITVGILLSYALNYALAGTPWGWRHMFG 190
Cdd:cd17436   81 LILTLAGSFFWLVIGRAVVGFAISVSSMACCIYVSEMVTPHQRGLLVSLYEAGITVGILISYALNYFFSNVLTGWRYMFG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 191 WATAPAVLQSLSLLFLPAGTDETAThkdliplqggeapklgpgrprysfldlfraRDNMRGRTTVGLGLVLFQQLTGQPN 270
Cdd:cd17436  161 LAIIPAAIQFASILLLPKKPEVLNI------------------------------KDNMRRRTLVGLGLVLFQQFTGQPN 210
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 768018403 271 VLCYASTIFSSVGFHGGSSAVLASVGLGAVKVAATLTAMGLVDRAGRRALLLAGCALMALSVSGIGL 337
Cdd:cd17436  211 VLCYASTIFRSVGFQSNSSAVLASVGLGVVKVIATLLAMLFADRAGRRSLLIAGCSVMAVSVSGIGL 277
MFS_GLUT10_12_Class3_like cd17362
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ...
35-450 2.53e-105

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340920 [Multi-domain]  Cd Length: 389  Bit Score: 320.07  E-value: 2.53e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  35 VSLLGGLTFGYELAVISGALLPLQLD-------FGLSCLEQEFLVGSLLLGALLASLVGGFLIDCYGRKQAILGSNLVLL 107
Cdd:cd17362    1 FPALGGLLFGYDIGATSGALLSITSPalsgtdwYNLSSLQSGLVVSGSLLGALLGSLVAGALIDRLGRRKELILAALLYL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 108 AGSLTLGLAGSLAWLVLGRAVVGFAISLSSMACCIYVSELVGPRQRGVLVSLYEAGITVGILLSYALNYALAGTPWGWRH 187
Cdd:cd17362   81 VGSLVTGLAPSYPVLLVGRLIYGVGIGLAMHAAPVYIAETSPSHIRGLLVSLKELFIVLGILLGYVSGYAFADVVGGWRY 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 188 MFGWATAPAVLQSLSLLFLPAGTdetathkdliplqggeapklgpgrprysfldlfRARDNMRGRTTVGLGLVLFQQLTG 267
Cdd:cd17362  161 MYGLAAPPALLLGIGMWFLPPSP---------------------------------RWQGNYRKPLIIGLGLVLFQQITG 207
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 268 QPNVLCYASTIFSSVGFHGGSSAVLASVGLGAVKVAATLTAMGLVDRAGRRALLLAGCALMALSVSGIGLVSFAVPMdsg 347
Cdd:cd17362  208 QPSVLYYAATIFKSAGFSAASDATLVSVGLGVFKLLMTIVAVLLVDKLGRRPLLLGGVSGMVVSLFLLAAYNLFVQM--- 284
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 348 psclavpnatgqtglpgdsgllqdsslppiprtnedqrepilstakktkphprsgdpsapprlalssalpgpplparGHA 427
Cdd:cd17362  285 -----------------------------------------------------------------------------GPA 287
                        410       420
                 ....*....|....*....|...
gi 768018403 428 LLRWTALLCLMVFVSAFSFGFGP 450
Cdd:cd17362  288 GLAWLSLVALLLYVGAYQISFGP 310
MFS_GLUT12_Class3 cd17435
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ...
31-337 4.02e-73

Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340993 [Multi-domain]  Cd Length: 376  Bit Score: 236.23  E-value: 4.02e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  31 LCASVSLLGGLTFGYELAVISGALLPLQLDFGLSCLEQEFLVGSLLLGALLASLVGGFLIDCYGRKQAILGSNLVLLAGS 110
Cdd:cd17435    1 LSSVTAAVSGLLVGYELGIISGALLQLRTLLALSCHEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILTSCLLVLGS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 111 LTLGLAGSLAWLVLGRAVVGFAISLSSMACCIYVSELVGPRQRGVLVSLYEAGITVGILLSYALNYALAGTPWGWRHMFG 190
Cdd:cd17435   81 LLLVCSVSYTVLIVGRIAIGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILLAYISNYAFANVSNGWKYMFG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 191 WATAPAVLQSLSLLFLPAGtdetathkdliplqggeapklgpgrPRYsfldlFRARDNMRGRTTVGLGLVLFQQLTGQPN 270
Cdd:cd17435  161 LVIPLAALQAIAMYFLPPS-------------------------PRF-----LVMKDNMRARLLIGLTLVFFVQITGQPN 210
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 768018403 271 VLCYASTIFSSVGFHGGSSAVLASVGLGAVKVAATLTAMGLVDRAGRRALLLAGCALMALSVSGIGL 337
Cdd:cd17435  211 ILFYASTVLKSVGFQSNEAASLASTGVGVVKVVSTIPAIFLVDKVGSKTFLCIGSSVMAVSLVTMGL 277
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
35-353 2.12e-59

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 200.11  E-value: 2.12e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  35 VSLLGGLTFGYELAVISGALLPLQ--LDFGLSCLEQEFLVGSLLLGALLASLVGGFLIDCYGRKQAILGSNLVLLAGSLT 112
Cdd:cd17315    1 VAALGGLLFGYDLGVINGALLYIAkdLGFGLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 113 LGLAGSLAWLVLGRAVVGFAISLSSMACCIYVSELVGPRQRGVLVSLYEAGITVGILLSYALNYALAGT-PWGWRHMFGW 191
Cdd:cd17315   81 SALAPNVWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSLSpPGWWRLMFAL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 192 ATAPAVLQSLSLLFLPAGtdetathkdliplqggeapklgpgrprysfldlfrardnmrGRTTVGLGLVLFQQLTGQPNV 271
Cdd:cd17315  161 AAVPALLQLLLMFFLPES-----------------------------------------RALLVGVGLQLLQQLTGINAV 199
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 272 LCYASTIFSSVGfhGGSSAVLASVGLGAVKVAATLTAMGLVDRAGRRALLLAGCALMALSVSGIGLVSFAVPMDSGPSCL 351
Cdd:cd17315  200 MYYAPTIFKSAG--GGTASILASIIVGVVNLLATLVAIRLVDKVGRRPLLLIGFAGMAASLLLLAIAFLLPALAKAAGWL 277

                 ..
gi 768018403 352 AV 353
Cdd:cd17315  278 AL 279
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
33-353 1.11e-53

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 185.46  E-value: 1.11e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  33 ASVSLLGGLTFGYELAVISGALLPLQLDFGLSCLEQEFLVGSLLLGALLASLVGGFLIDCYGRKQAILGSNLVLLAGSLT 112
Cdd:cd17359    3 SLVAALGGLLFGYDTGVINGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALG 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 113 LGLAGSLAWLVLGRAVVGFAISLSSMACCIYVSELVGPRQRGVLVSLYEAGITVGILLSYALNYALAGT---PW----GW 185
Cdd:cd17359   83 SAFSPNFTIFIIARIIGGLAVGGASALVPMYIAEVAPAEIRGRLVSLNQLMIVFGQLLAYIVNYLIANAggaDWlgaeGW 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 186 RHMFGWATAPAVLQSLSLLFLPagtdETathkdliplqggeapklgpgrPRYSFldlfrardnMRGRTTV--GLGLVLFQ 263
Cdd:cd17359  163 RWMLGLEAIPAILFLLGMLFIP----ES---------------------PRWLV---------SKGKPILiiGIGLAIFQ 208
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 264 QLTGQPNVLCYASTIFSSVGFhGGSSAVLASVGLGAVKVAATLTAMGLVDRAGRRALLLAGCALMALSVSGIGLVSFAVP 343
Cdd:cd17359  209 QFVGINVIFYYGPEIFQNAGF-SENAALLQTIGIGVVNVIFTIIAILLVDKVGRKPLLLIGSIGMAISLLLIGTAFYFAP 287
                        330
                 ....*....|
gi 768018403 344 MDSGPSCLAV 353
Cdd:cd17359  288 GSQASGIVAL 297
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
35-338 2.40e-52

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 181.31  E-value: 2.40e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  35 VSLLGGLTFGYELAVISGALLPLQLDFG---LSCLEQEFLVGSLLLGALLASLVGGFLIDCYGRKQAILGSNLVLLAGSL 111
Cdd:cd17360    1 FAGIGGFLFGYDTGVISGALLYIKDDLGevvLSTGWQELIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 112 TLGLAGSLAWLVLGRAVVGFAISLSSMACCIYVSELVGPRQRGVLVSLYEAGITVGILLSYALNYALAGTPWGWRHMFGW 191
Cdd:cd17360   81 VMAAAPNKEVLIVGRVLVGLGVGIASMTVPLYIAEAAPPRIRGRLVTINVLFITGGQFVAYVINGAFSYLPGGWRWMLGL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 192 ATAPAVLQSLSLLFLPagtdetathkdliplqggEAPKLGPgrprysfldlfrardnMRGRTTVGLGLVLFQQLTGQPNV 271
Cdd:cd17360  161 AAVPAVLQFIGLLFLP------------------ESPRWPS----------------TRRALIVGCGLQAFQQFSGINTV 206
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 768018403 272 LCYASTIFSSVGFHGGSSAVLASVGLGAVKVAATLTAMGLVDRAGRRALLLAGCALM--ALSVSGIGLV 338
Cdd:cd17360  207 MYYSATILQMAGFKDNQNAIWLSLIVAGTNFIFTIVGMYLIDKFGRRKLLLISLFGVivALVVLAVWLA 275
Sugar_tr pfam00083
Sugar (and other) transporter;
32-343 4.51e-45

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 163.98  E-value: 4.51e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403   32 CASVSLLGGLTFGYELAVISGALLPLQ--LDFGLSCLEQEFLVGSLLLGALLASLV---------GGFLIDCYGRKQAIL 100
Cdd:pfam00083   1 VALVAALGGFLFGYDTGVIGAFLTLIDffKNFGLSKSVSSLAALSVLSGLIVSIFSvgcfigslfAGKLGDRFGRKKSLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  101 GSNLVLLAGSLTLGLA---GSLAWLVLGRAVVGFAISLSSMACCIYVSELVGPRQRGVLVSLYEAGITVGILLSYALNYA 177
Cdd:pfam00083  81 IANVLFVIGAVLQGAAkgkWSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGLG 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  178 LA--GTPWGWRHMFGWATAPAVLQSLSLLFLP--------AGTDETAThKDLIPLQGGEAPKL-----------GPGRPR 236
Cdd:pfam00083 161 LNktSNSDGWRIPLGLQLVPALLLIIGLLFLPesprwlveKGRLEEAR-EVLAKLRGVPDVDReldeikdsleaGQEAEK 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  237 YSFLDLFRARdNMRGRTTVGLGLVLFQQLTGQPNVLCYASTIFSSVGFhggSSAVLASVGLGAVKVAATLTAMGLVDRAG 316
Cdd:pfam00083 240 ASWKELFSTK-TRRQRLLIGVMLQIFQQLTGINAIFYYSTTIFENLGL---SDSFLVTIIVGVVNFVFTFIAIFLVDRFG 315
                         330       340
                  ....*....|....*....|....*..
gi 768018403  317 RRALLLAGCALMALSVSGIGLVSFAVP 343
Cdd:pfam00083 316 RRPLLLLGAAGMAICFVILGIVALLGV 342
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
25-340 9.56e-45

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 164.05  E-value: 9.56e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403   25 SPPVLPLCASVSLlGGLTFGYELAVISGAL--------LPLQLDFGLSCLEQEFLVGSLLLGALLASLVGGFLIDCYGRK 96
Cdd:TIGR00879  23 YWKVALLSLIAAI-GGLMFGYDTGVIGGALalpafefkFTSANSDSYSSSLWGLVVSIFLVGGFIGALFAGWLSDRFGRK 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403   97 QAILGSNLVLLAGSLTLGLAG---SLAWLVLGRAVVGFAISLSSMACCIYVSELVGPRQRGVLVSLYEAGITVGILLSYA 173
Cdd:TIGR00879 102 KSLLIIALLFVIGAILMGLAAfalSVEMLIVGRVLLGIGVGIASALVPMYLSEIAPKALRGALTSLYQLAITFGILVAYG 181
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  174 LNYA--LAGTPWGWRHMFGWATAPAVLQSLSLLFLPA--------GTDETAThKDLIPLQGGEAP--------------- 228
Cdd:TIGR00879 182 FGSGkvSLNNTLGWRIPLGLQLIPAGLLFLGLFFLPEsprwlvgkGRVEEAR-KSLARLRGTSGEdkelldelelidikr 260
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  229 KLGPGRPRYSFLDLFRARDNMRGRTTVGLGLVLFQQLTGQPNVLCYASTIFSSVGFhGGSSAVLASVGLGAVKVAATLTA 308
Cdd:TIGR00879 261 SIEKRSVQPSWGSLFSSTRRIRRRLFLGVVLQWFQQFTGINAIMYYSPTIFENAGV-STDHAFLVSIIVGAVNFAFTFVA 339
                         330       340       350
                  ....*....|....*....|....*....|..
gi 768018403  309 MGLVDRAGRRALLLAGCALMALSVSGIGLVSF 340
Cdd:TIGR00879 340 IFLVDRFGRRPLLLIGAAGMAICLFVLGILGA 371
MFS_STP cd17361
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ...
93-338 3.32e-37

Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340919 [Multi-domain]  Cd Length: 390  Bit Score: 141.23  E-value: 3.32e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  93 YGRKQAILGSNLVLLAGSLTLGLAGSLAWLVLGRAVVGFAISLSSMACCIYVSELVGPRQRGVLVSLYEAGITVGILLSY 172
Cdd:cd17361   78 WGRKPSMLIGGVLFLVGAALNAAAQNIAMLIVGRILLGFGVGFGNQAVPLYLSEMAPAKLRGALNIGFQLAITIGILIAN 157
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 173 ALNYALAG-TPWGWRHMFGWATAPAVLQSLSLLFLPagtdETAThkdliplqggeAPKLgpgrprysfldlfrardnmrg 251
Cdd:cd17361  158 LINYGTSKiKPNGWRLSLGLAAVPALILLLGSLFLP----ETPN-----------SPQL--------------------- 201
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 252 rtTVGLGLVLFQQLTGQPNVLCYASTIFSSVGFhGGSSAVLASVGLGAVKVAATLTAMGLVDRAGRRALLLAGCALMALS 331
Cdd:cd17361  202 --VIAILIPFFQQLTGINVIMFYAPVLFQTLGF-GSDASLISAVITGAVNVVSTLVSIYLVDRFGRRFLLLEGGVQMLAS 278

                 ....*..
gi 768018403 332 VSGIGLV 338
Cdd:cd17361  279 QVAIGIL 285
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
31-349 5.38e-36

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 138.86  E-value: 5.38e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  31 LCASVSLLGGLTFGYELAVISGALLPLQ----LDFGLSCLEQEFLVGSLLLGALLASLVGGFLIDCYGRKQAILGSNLVL 106
Cdd:cd17358    2 LATFVANLGSFSFGIAVGWSSPALPSLMsdnsLSLPLTVAQFSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIPC 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 107 LAGSLTLGLAGSLAWLVLGRAVVGFAISLSSMACCIYVSELVGPRQRGVLVSLYEAGITVGILLSYALNYALAgtpwgWR 186
Cdd:cd17358   82 ILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNVRGALGSLNQLLVNIGILLGYVLGSFLP-----WR 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 187 HMFGWATAPAVLQSLSLLFLPA--------GTDETAtHKDLIPLQGGEAP-------------KLGPGRPRYSFLDLFRA 245
Cdd:cd17358  157 TLALIGAIPPVVFLILLFFIPEsprwlakkGREEEA-EKSLQFLRGKDADiskeaaeiqeelaELEKEAKESSFSDLFQR 235
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 246 RdNMRGrTTVGLGLVLFQQLTGQPNVLCYASTIFSSVGfhGGSSAVLASVGLGAVKVAATLTAMGLVDRAGRRALLLAGC 325
Cdd:cd17358  236 K-YLKP-LVIGLGLMLFQQLSGINAVIFYASSIFDEAG--SGLDPNTATIIIGVVQVVGTLVATLLVDRLGRRPLLLVSA 311
                        330       340
                 ....*....|....*....|....
gi 768018403 326 ALMALSVSGIGLvSFAVPMDSGPS 349
Cdd:cd17358  312 IGMGIGLLALGL-YFYLQEHGALL 334
MFS_PLT cd17437
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ...
43-337 1.24e-35

Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340995 [Multi-domain]  Cd Length: 387  Bit Score: 136.76  E-value: 1.24e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  43 FGYELAVISGALLPLQLDFGLSCLEQEFLVGSLLLGALLASLVGGFLIDCYGRKQAILGSNLVLLAGSLTLGLAGSLAWL 122
Cdd:cd17437    9 LGYDIGVMSGAVIFIKEDLKISDVQEEVLIGSLNIISLVGSLAAGRTSDWIGRRYTIALAALIFFVGALLMGVAPNYPVL 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 123 VLGRAVVGFAISLSSMACCIYVSELVGPRQRGVLVSLYEAGITVGILLSYALNYALAGTPW--GWRHMFGWATAPAVLQS 200
Cdd:cd17437   89 MVGRFVAGIGVGFALMIAPVYTAEVAPASSRGFLTSFPEIFINIGILLGYVSNYAFSGLPLhvGWRLMLGVGAVPSLFLA 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 201 LSLLFLPagtdetathkdliplqggEAPKLGPGrprysfldlfrardnMRGRTTVGLGLVLFQQLTGQPNVLCYASTIFS 280
Cdd:cd17437  169 IGVLAMP------------------ESPRWTPA---------------VRRMLIAALGIHFFQQASGIDAVVLYSPRIFK 215
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 768018403 281 SVGFHGGSSAVLASVGLGAVKVAATLTAMGLVDRAGRRALLLAGCALMALSVSGIGL 337
Cdd:cd17437  216 KAGIKSKDKLLLATVAVGVTKTLFILVATFLLDKVGRRPLLLTSTGGMTLSLTALAT 272
MFS_GLUT_Class1 cd17431
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
31-331 3.22e-32

Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-4 are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT1, also called solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), displays broad substrate specificity and can transport a wide range of pentoses and hexoses including glucose, galactose, mannose, and glucosamine. It is found in the brain, erythrocytes, and in many fetal tissues. GLUT2 (or SLC2A2) is found in the liver, islet of Langerhans, intestine, and kidney, and is the isoform that likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by beta cells. GLUT3 (or SLC2A3) is found in the brain and can mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and dehydroascorbate. GLUT4 (or SLC2A4) is an insulin-regulated facilitative glucose transporter found in adipose tissues, and in skeletal and cardiac muscle. GLUT14 (or SLC2A14) is an orphan transporter expressed mainly in the testis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340989 [Multi-domain]  Cd Length: 445  Bit Score: 128.22  E-value: 3.22e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  31 LCASVSLLGGLTFGYELAVISgALLPLQLDFGLSCLEQEFLVGSLLLGALLA---------------SLVGGFLIDCYGR 95
Cdd:cd17431    1 FAVFVAVLGSLQFGYNTGVIN-APQKVIEEFYNKTLGDRYGEPISPETLTTLwslsvaifsvggmigSFSVGLFVNRFGR 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  96 KQAILGSNLVLLAGSLTLGL---AGSLAWLVLGRAVVGFAISLSSMACCIYVSELVGPRQRGVLVSLYEAGITVGILLSY 172
Cdd:cd17431   80 RNSMLYNNLLAFAGAALMGLsklAKSYEMLILGRFIIGLYCGLTTGLVPMYIGEISPTALRGALGTLHQLGIVVGILISQ 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 173 ALNY-ALAGTPWGWRHMFGWATAPAVLQSLSLLFLPAG--------TDETATHKDLIPLQG------------GEAPKLG 231
Cdd:cd17431  160 IFGLeFILGTEELWPLLLGFTIVPAILQLALLPFCPESpryllinrNEEEEAKSVLKKLRGttdvsediqemkEESRQMM 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 232 PGRpRYSFLDLFRARDNmRGRTTVGLGLVLFQQLTGQPNVLCYASTIFSSVgfhGGSSAVLASVGLGAVKVAATLTAMGL 311
Cdd:cd17431  240 REK-KVTILELFRSSSY-RQPIIIAIVLQLSQQLSGINAVFYYSTSIFEKA---GVQQPVYATIGAGVVNTIFTVVSLFL 314
                        330       340
                 ....*....|....*....|
gi 768018403 312 VDRAGRRALLLAGCALMALS 331
Cdd:cd17431  315 VERAGRRTLHLIGLGGMAIC 334
xylE PRK10077
D-xylose transporter XylE; Provisional
33-341 3.47e-31

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 125.96  E-value: 3.47e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  33 ASVSLLGGLTFGYELAVISGA--------LLPLQLDFGLSCLEQEFLVGSLLLGALLASLVGGFLIDCYGRKQA-ILGSN 103
Cdd:PRK10077  14 TLVATLGGLLFGYDTAVISGTveslntvfVAPQNLSESAANSLLGFCVASALIGCIIGGALGGYCSNRFGRRDSlKIAAV 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 104 LVLLAGsltLGLA-----------GSLAWL---VLGRAVVGFAISLSSMACCIYVSELVGPRQRGVLVSLYEAGITVGIL 169
Cdd:PRK10077  94 LFFISA---LGSAwpefgftsigpDNTGYVpefVIYRIIGGIGVGLASMLSPMYIAEIAPAHIRGKLVSFNQFAIIFGQL 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 170 LSYALNYALAGTP---W----GWRHMFGWATAPAVLQSLSLLFLPagtdET-----ATHKD------LIPLQGGEAPK-- 229
Cdd:PRK10077 171 VVYFVNYFIARSGdasWlntdGWRYMFASEAIPALLFLMLLYFVP----ETprylmSRGKQeqaegiLRKIMGNTLATqa 246
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 230 -------LGPGRPRYSFLDLFRArdnmrGRTTVGLGLVLFQQLTGQPNVLCYASTIFSSVGFhGGSSAVLASVGLGAVKV 302
Cdd:PRK10077 247 lqeikhsLDHGRKTGGKLLMFGV-----GVIVIGVMLSVFQQFVGINVVLYYAPEIFKTLGA-STDIALLQTIIVGVINL 320
                        330       340       350
                 ....*....|....*....|....*....|....*....
gi 768018403 303 AATLTAMGLVDRAGRRALLLAGCALMALSVSGIGLVSFA 341
Cdd:PRK10077 321 TFTVLAIMTVDKFGRKPLQIIGALGMAIGMFSLGTAFYT 359
MFS_HXT cd17356
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...
31-338 3.10e-27

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340914 [Multi-domain]  Cd Length: 403  Bit Score: 113.11  E-value: 3.10e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  31 LCASVSLLGGLTFGYELAVISGALLplQLDF-----------GLSCLEQEFLVGSLLLGALLASLVGGFLIDCYGRKQAI 99
Cdd:cd17356    1 LLCAFVSLGGFLFGYDTGSISGILN--MKSFqkyfadntgtyYPSSSRQGLIVSIVNLGSFFGALISSFLSDRIGRKKSI 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 100 LGSNLVLLAGSLTLGLA-GSLAWLVLGRAVVGFAISLSSMACCIYVSELVGPRQRGVLVSLYEAGITVGILLSYALNYAL 178
Cdd:cd17356   79 QIGCVIYIIGAIIQVAAiGKWYQLIVGRIIAGLGVGFASVLVPVYQSEVAPKHIRGTLVSLYQLAITIGILVAYCINYGT 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 179 A---GTPWgWRHMFGWATAPAVLQSLSLLFLPagtdETathkdliplqggeapklgpgrPRYSFldlfrardnmrgRTTV 255
Cdd:cd17356  159 HkldGSAQ-WRIPLGLQIVWGLLLLIGMFFLP----ES---------------------PRWLY------------RTIL 200
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 256 GLGLVLFQQLTGQPNVLCYASTIFSSVGFhGGSSAVLASVGLGAVKVAATLTAMGLVDRAGRRALLLAGCALMALSVSGI 335
Cdd:cd17356  201 GIMLQLFQQLTGINYFFYYGTTIFQSTGL-TGSSPLLTSIILYIVNFVSTIPGLFFVDKFGRRTCLLIGAAGMSICLFIY 279

                 ...
gi 768018403 336 GLV 338
Cdd:cd17356  280 AAV 282
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
86-330 1.68e-25

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 108.89  E-value: 1.68e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  86 GGFLIDCYGRKQAILGSNLVLLAGSLTLGLAGSLAW---LVLGRAVVGFAISLSSMACCIYVSELVGPRQRGVLVSLYEA 162
Cdd:cd17357   69 SAFLANRFGRKNGLLISNALLVVSSLLMFLSKSAKSpelLIFGRFLVGIACGLSTGFVPMYLQEISPSELRGALGSLTQI 148
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 163 GITVGILLS--YALNYALaGTPWGWRHMFGWATAPAVLQSLSLLFLP--------AGTDETATHKDLIPLQGGEAPKL-- 230
Cdd:cd17357  149 GVTLGILLGqvFGLPSVL-GTETLWPYLLFFPGIPALLQLAALPFFPespkflliSKGDEEEAEKSLKFLRGIEDDVDqe 227
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 231 ------------GPGRPrySFLDLFRARDNmRGRTTVGLGLVLFQQLTGQPNVLCYASTIFSSVGFHGGSSAvLASVGLG 298
Cdd:cd17357  228 leeikkeseqmgDQKQV--SLMQLLRDPSL-RLPLLLVLVVSASQQFSGINAIFFYSTFIFENAGFSPQLAE-WANLGIG 303
                        250       260       270
                 ....*....|....*....|....*....|..
gi 768018403 299 AVKVAATLTAMGLVDRAGRRALLLAGCALMAL 330
Cdd:cd17357  304 IVNVLSTIVGPFLIEKVGRRPLLLISLSVCAV 335
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
37-344 3.49e-23

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 100.43  E-value: 3.49e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  37 LLGGLTFGYELAVISGALLPLQLDFGLSCLEQEFLVGSLLLGALLASLVGGFLIDCYGRKQAILGSNLVLLAGSLTLGLA 116
Cdd:COG2814   16 ALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALA 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 117 GSLAWLVLGRAVVGFAISLSSMACCIYVSELVGPRQRGVLVSLYEAGITVGILLSYALNYALAGTpWGWRHMFGWATAPA 196
Cdd:COG2814   96 PSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADL-FGWRWVFLVNAVLA 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 197 VLQSLSLLFlpagtdetathkdLIPlqggEAPKLGPGRPRYSFLDLFRArdnmrgRTTVGLGLVLFQQLTGQPNVLCYAS 276
Cdd:COG2814  175 LLALLLLLR-------------LLP----ESRPAARARLRGSLRELLRR------PRLLLLLLLAFLLGFGFFALFTYLP 231
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 768018403 277 TIFSSVGFHGGSSAVLASVGLGAVKVAATLTAMGLVDRAGRRALLLAGCALMALSVSGIGLVSFAVPM 344
Cdd:COG2814  232 LYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLL 299
MFS_GLUT8_Class3 cd17433
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
31-336 1.27e-21

Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340991 [Multi-domain]  Cd Length: 416  Bit Score: 96.87  E-value: 1.27e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  31 LCASVSLLGGLTFGYELAVISGALLPLQ----LDFGLSCLEQEFLVGSLLLGALLASLVGGFLIDCYGRKQAILGSNLVL 106
Cdd:cd17433    2 LATFAAVLGPLSFGFVLGYSSPAIPSLQriadPALRLDDAAASWFGSVVTLGAAAGGVLGGWIVDRAGRKLSLMLCSVPF 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 107 LAGSLTLGLAGSLAWLVLGRAVVGFAISLSSMACCIYVSELVGPRQRGVLVSLYEAGITVGILLSYalnyaLAGTPWGWR 186
Cdd:cd17433   82 IAGFTVITAAQNVWMLYVGRLLTGLASGVTSLVVPVYISEIAHPRVRGTLGSCVQLMVVIGIMGAY-----LAGLVLDWR 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 187 HMFGWATAPAVLQSLSLLFLPAGTDETATHKD-------LIPLQGGEAPKLGPGRP-------RYSFLDLFRARD-NMRG 251
Cdd:cd17433  157 WLAVLGSIPPTLMLLLMCFMPETPRFLLTQHRrqeamaaLRFLRGPDQGWEWECIGieqsfhlEEQSFSLALLKQpGIYK 236
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 252 RTTVGLGLVLFQQLTGQPNVLCYASTIFSSVGFHGGSsavLASVGLGAVKVAATLTAMGLVDRAGRRALLLAGCALMALS 331
Cdd:cd17433  237 PLIIGVSLMAFQQLTGINAVMFYAETIFEEAKFKDSS---VASVIVAAIQVLFTAVAALIMDRAGRKVLLVLSGVVMVFS 313

                 ....*
gi 768018403 332 VSGIG 336
Cdd:cd17433  314 TAAFG 318
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
37-361 1.97e-20

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 92.87  E-value: 1.97e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  37 LLGGLTFGYELAVISGALLPLQLDFGLSCLEQEFLVGSLLLGALLASLVGGFLIDCYGRKQAILGSNLVLLAGSLTLGLA 116
Cdd:cd06174    2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 117 GSLAWLVLGRAVVGFAISLSSMACCIYVSELVGPRQRGVLVSLYEAGITVGILLSYALNYALA-GTPWGWRHMFGWATAP 195
Cdd:cd06174   82 PSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILAsSLGFGWRAVFLIAAAL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 196 AVLQSLSLLFLPAgtdetathkdliPLQGGEAPKLGPGRPRYSFLDLFRARDNmrgRTTVGLGLVLFQQLTGQPNVLCYA 275
Cdd:cd06174  162 ALLAAILLLLVVP------------DPPESARAKNEEASSKSVLKLLKRVLKN---PGLWLLLLAIFLVNLAYYSFSTLL 226
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 276 STIFSSVGFHGGSSAVLASVGLGAVKVAATLTAMGLVDR-AGRRALLLAGCALMALSVSGIGLVSFAVPMDSGPSCLAVP 354
Cdd:cd06174  227 PLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFG 306

                 ....*..
gi 768018403 355 NATGQTG 361
Cdd:cd06174  307 LGGLLPL 313
MFS_GLUT_Class2 cd17432
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
87-335 4.11e-20

Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340990 [Multi-domain]  Cd Length: 452  Bit Score: 92.68  E-value: 4.11e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  87 GFLIDCYGRKQAILGSNLVLLAGSLTLGL---AGSLAWLVLGRAVVGFAISLSSMACCIYVSELVGPRQRGVLVSLYEAG 163
Cdd:cd17432   71 GPLVIRLGRKGTLLLNNIFAIVAAILMGLskiAKSFEMIIVGRFLVGINAGISLNVVPMYLGESAPKNLRGAVGLVPAIF 150
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 164 ITVGILLSYALNY-ALAGTPWGWRHMFGWATAPAVLQSLSLLFLPAG--------TDETATHKDLIPLQG---------- 224
Cdd:cd17432  151 ITLGILLGQVLGLrELLGNEEGWPLLLALTGVPALLQLLTLPFFPESprylliekGDEEAARKALQRLRGkedvddemee 230
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 225 --GEAPKLGPGRPRySFLDLFRARDNMRGRTTVglgLVLF--QQLTGQPNVLCYASTIFSSVGFHGGSSAvLASVGLGAV 300
Cdd:cd17432  231 mlEEQRAEKGVGTV-SVLELFRDRSVRWQLISI---IVLMagQQLCGINAIYFYADSIFLEAGIPEDKIQ-YVTVGTGAC 305
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 768018403 301 KVAATLTAMGLVDRAGRRALLLAGCALMALSVSGI 335
Cdd:cd17432  306 EVLATITCVLVIERLGRRPLLIGGFGLMAVWCAVL 340
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
35-332 1.33e-17

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 83.32  E-value: 1.33e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  35 VSLLGGLTFGYELAVISGALLPLQLDFGLSCLEQEFLVGSLLLGALLASLVGGFLIDCYGRKQAILGSNLVLLAGSLTLG 114
Cdd:COG0477   18 ALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCG 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 115 LAGSLAWLVLGRAVVGFAISLSSMACCIYVSELVGPRQRGVLVSLYEAGITVGILLSYALNYALAGTpWGWRHMFGWATA 194
Cdd:COG0477   98 LAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAA-LGWRWIFLINAP 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 195 PAVLQSLSLLFLPagtdetathkdliplqggeAPKLGPGRPRYSFLDLFRARDNMRGRTTVGLGLVLFQQLTGQPNVLCY 274
Cdd:COG0477  177 LGLLALVLRLRLP-------------------ESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGA 237
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 768018403 275 ASTIFSSVGFHGGSSAVLASVGLGAVKVAATLTAMGLVDRAGRRALLLAGCALMALSV 332
Cdd:COG0477  238 ALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
87-332 4.54e-15

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 76.82  E-value: 4.54e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  87 GFLIDCYGRKQAILGSNLVLLAGSLTLGLAGSLAWLVLGRAVVGFAISLSSMACCIYVSELVGPRQRGVLVSLYEAGITV 166
Cdd:cd17324   55 GPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTL 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 167 GILLSYALNyALAGTPWGWRHMFgWATAPAVLQSLSLLFLpagtdetathkdLIPLQGGEAPklgpgRPRYSFLDLFRAR 246
Cdd:cd17324  135 GLVLGRPLG-GLLGQLLGWRAAF-LAIAVLALLAALLLWR------------LLPSLPPKKP-----GSLGLLSSLLLLL 195
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 247 DNMRGRTTVGLGLVLFqqlTGQPNVLCYASTIFSSVGFHGGSSAVLASVGLGAVKVAATLTAMGLVDRAGRRALLLAGCA 326
Cdd:cd17324  196 RNPRLRLAYLITFLLF---GGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLL 272

                 ....*.
gi 768018403 327 LMALSV 332
Cdd:cd17324  273 LAAALL 278
MFS_1 pfam07690
Major Facilitator Superfamily;
37-342 1.10e-14

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 75.15  E-value: 1.10e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403   37 LLGGLTFGYELAVISGAL-LPLQLDFGLSCLEQEFLVGSLLLGALLASLVGGFLIDCYGRKQAILGSNLVLLAGSLTLGL 115
Cdd:pfam07690   2 FLAAFLAALGRSLLGPALpLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  116 AGSLAWLVLGRAVVGFAISLSSMACCIYVSELVGPRQRGVLVSLYEAGITVGILLSYALNYALAGTpWGWRHMFgWATAP 195
Cdd:pfam07690  82 ASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASL-FGWRAAF-LILAI 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  196 AVLQSLSLLFLPagtDETATHKDLIPLQGGEAPKLGPgrprysFLDLFRARDNMRGRTTVGLGLVLFQQLTgqpnvlcYA 275
Cdd:pfam07690 160 LSLLAAVLLLLP---RPPPESKRPKPAEEARLSLIVA------WKALLRDPVLWLLLALLLFGFAFFGLLT-------YL 223
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 768018403  276 STIFSSVGFHGGSSAVLASVGLGAVKVAATLTAmGLVDRAGRRALLLAGCALMALSVSGIGLVSFAV 342
Cdd:pfam07690 224 PLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLG-RLSDRLGRRRRLLLALLLLILAALGLLLLSLTL 289
MFS_GLUT6_Class3 cd17434
Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
88-344 2.44e-14

Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 6 (GLUT6) is also called Solute carrier family 2, facilitated glucose transporter member 6 (SLC2A6). It is classified as a Class 3 GLUT protein, and is a facilitative glucose transporter that binds cytochalasin B with low affinity. It is found in the brain, spleen, and leucocytes. GLUT6 may function in oxalate secretion. SLC2A6 has been identified as an oxalate nephrolithiasis gene in mice; its deletion causes spontaneous calcium oxalate nephrolithiasis in the setting of hyperoxalaemia, hyperoxaluria, and nephrocalcinosis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340992 [Multi-domain]  Cd Length: 417  Bit Score: 74.87  E-value: 2.44e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  88 FLIDCYGRKQAILGSNLVLLAGSLTLGLAGSLAWLVLGRAVVGFAISLSSMACCIYVSELVGPRQRGVLVSLYEAGITVG 167
Cdd:cd17434   63 FLNDRLGRKLSIMFSAVPSALGYLLMGSAQGIWMLLLGRFLTGFAGGITAASIPVYVSEISHPGVRGALGACPQIMAVFG 142
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 168 ILLSYALNYALagtPWGWRHMFGwaTAPAVLQSLSLLFLP--------AGTDETAThKDLIPLQG------GEAPKLGPG 233
Cdd:cd17434  143 SLALYALGLLL---PWRWLAVAG--EVPVVIMILLLCFMPnsprflisKGKDEKAL-KALAWLRGpntdymTEFEQIKDN 216
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 234 -RPRYSFLDLFRARDNMRGR-TTVGLGLVLFQQLTGQPNVLCYASTIF--SSVGFHGGSSAVLasvgLGAVKVAATLTAM 309
Cdd:cd17434  217 iRKQSSRLSWAELKTPSYYKpILIAVVMRFLQQLTGITPILVYLEPIFhlTAVILEPKYDAAL----VGAVRLLSVAIAA 292
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 768018403 310 GLVDRAGRRALLLAGCALMALSVSGIGLVSFAVPM 344
Cdd:cd17434  293 SLMDKAGRKILLFTSAFLMFAANLSMGLIPLIAAM 327
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
86-338 4.09e-14

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 73.79  E-value: 4.09e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  86 GGFLIDCYGRKQAILGSNLVLLAGSLTLGLAGSLAWLVLGRAVVGFAISLSSMACCIYVSELVGPRQRGVLVSLYEAGIT 165
Cdd:cd17316   56 FGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWA 135
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 166 VGILLSYALNYAL---AGTPWGWRHMFGWATAPAVLqslsLLFLpagtdetathkdliplqggeapklgpgrprysfldl 242
Cdd:cd17316  136 LGALLAALVASLLiplLSGDWGWRILFLIGALPALL----ALLL------------------------------------ 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 243 frardnmRGRTTVGLGLVLFQQLTGQPnVLCYASTIFSSVGFHGGSSAVLASVGLGAVKVAATLTAMGLVDRAGRRALLL 322
Cdd:cd17316  176 -------RRRTLLLILLWFFISFGYYG-LTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLV 247
                        250
                 ....*....|....*.
gi 768018403 323 AGCALMALSVSGIGLV 338
Cdd:cd17316  248 IGLILSGILALPLFYL 263
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
35-198 6.12e-14

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 72.98  E-value: 6.12e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  35 VSLLGGLTFGYELAVISGALLPLQLDFGLSCLEQEFLVGSLLLGALLASLVGGFLIDCYGRKQAILGSNLVLLAGSLTLG 114
Cdd:COG2271   14 LLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFG 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 115 LAGSLAWLVLGRAVVGFAISLSSMACCIYVSELVGPRQRGVLVSLYEAGITVGILLSYALNYALAGTpWGWRHMFGWATA 194
Cdd:COG2271   94 FATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA-FGWRAAFLILGL 172

                 ....
gi 768018403 195 PAVL 198
Cdd:COG2271  173 PGLL 176
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
86-344 5.85e-13

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 70.30  E-value: 5.85e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  86 GGFLIDCYGRKQAILGSNLVLLAGSLTLGLAGSLAWLVLGRAVVGFAISLSSMACCIYVSELVGPRQRGVLVSLYEAGIT 165
Cdd:cd17325   51 AGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIG 130
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 166 VGILLSYALNYALAGTpWGWRHMFGWATAPAVLqSLSLLFLPAGTDETATHKDLIPLQGGEAPKLGPGRPRYSFLDLFra 245
Cdd:cd17325  131 LGFLIGPLLGGLLADA-LGYRAPFLVCAALALL-ALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFL-- 206
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 246 rdnMRGRTTVGLGLVlfqqltgQPNVLCYASTIFssvGFHGGSSAVLASVGlGAVKVAATLTAMGLVDRAGRRALLLAGC 325
Cdd:cd17325  207 ---AIFVLAFAFGAL-------EPFLPLYAAELG---GLSPAQIGLLFGAQ-GLASALSQPPAGKLSDRIGRKPLILIGL 272
                        250
                 ....*....|....*....
gi 768018403 326 ALMALSVSGIGLVSFAVPM 344
Cdd:cd17325  273 LLSAVALLLLPLATSFWLL 291
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
35-322 1.51e-12

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 69.31  E-value: 1.51e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403   35 VSLLGGLTFGYELAVISGALLPLQLDFGLSCLEQEFLVGSLLLGALLASLVGGFLIDCYGRKQAILGSNLVLLAGSLTLG 114
Cdd:TIGR00895  21 LSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCA 100
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  115 LAGSLAWLVLGRAVVGFAISLSSMACCIYVSELVGPRQRGVLVSLYEAGITVGILLSYALNyALAGTPWGWRHMFGWAT- 193
Cdd:TIGR00895 101 LATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLA-GWLIPVFGWRSLFYVGGi 179
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  194 APAVLQSLSLLFLPAGTDETATHKDLIPLQGGEAPKLGPGRPRYSFLDLFRARDNmRGRTTVGLglvLFQQLTGQPNVLC 273
Cdd:TIGR00895 180 APLLLLLLLMRFLPESIDFLVSKRPETVRRIVNAIAPQMQAEAQSALPEQKSTQG-TKRSVFKA---LFQGKTARITVLL 255
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 768018403  274 YASTIFSSVGFHG------------GSSAVLASVGLGAVKVAATLTAM---GLVDRAGRRALLL 322
Cdd:TIGR00895 256 WLLYFMLLVGVYFltnwlpklmvelGFSLSLAATGGALFNFGGVIGSIifgWLADRLGPRVTAL 319
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
86-344 2.70e-12

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 68.37  E-value: 2.70e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  86 GGFLIDCYGRKQAILGSNLVLLAGSLTLGLAGSLAWLVLGRAVVGFAISLSSMACCIYVSELVGPRQRGVLVSLYEAGIT 165
Cdd:COG2223   60 LGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGN 139
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 166 VGILLSYALNYALAGTpWGWRHMFG-WATAPAVLQSLSLLFLPagtdetathkdliplqggEAPKLGPGRPRYSFLDLFR 244
Cdd:COG2223  140 LGAAVAAFLAPLLIAA-FGWRNAFLiLGILLLVVAVLAWLFLR------------------DPPAGAAAAAKASLRDQLE 200
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 245 ArdnMRGRTTVGLGlvlfqqltgqpnvLCYASTIFSSVGFHGGSSAVLASVGLGAVKVAATLTAMG-------------L 311
Cdd:COG2223  201 A---LRDPRFWLLS-------------LLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFallgalgrplggwL 264
                        250       260       270
                 ....*....|....*....|....*....|...
gi 768018403 312 VDRAGRRALLLAGCALMALSVSGIGLVSFAVPM 344
Cdd:COG2223  265 SDRIGGRRVLLIVFALMALGLLLLALALGSLWL 297
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
87-330 5.52e-12

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 67.73  E-value: 5.52e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403   87 GFLIDCYGRKQAILGSNLVLLAGSLTLGLAGSLAWLVLGRAVVGFAISLSSMACCIYVSELVGPRQRGVLVSLYEAGITV 166
Cdd:TIGR00898 148 GYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQRAIVGTLIQVFFSL 227
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  167 GILLSYALNYALAgtpwGWRHMFGWATAPAVLQSLSLLFLPA-------------------------GTDETATHKDLIP 221
Cdd:TIGR00898 228 GLVLLPLVAYFIP----DWRWLQLAVSLPTFLFFLLSWFVPEsprwlisqgrieealkilqriakinGKKLPAEVLSLSL 303
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  222 LQggeapKLGPGRPRYSFLDLFRARdNMRGRT--------TVGL---GLVLFQQLTGQpNVlcYASTIFSsvgfhggssa 290
Cdd:TIGR00898 304 EK-----DLSSSKKQYSFLDLFRTP-NLRKTTlclmmlwfTTAFsyyGLVLDLGNLGG-NI--YLDLFIS---------- 364
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 768018403  291 vlasvglGAVKVAATLTAMGLVDRAGRR-----ALLLAGCALMAL 330
Cdd:TIGR00898 365 -------GLVELPAKLITLLLIDRLGRRytmaaSLLLAGVALLLL 402
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
87-338 1.40e-11

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 66.05  E-value: 1.40e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  87 GFLIDCYGRKQAILGSNLVLLAGSLTLGLAGSLAWLVLGRAVVGFAIS-LSSMACCIyVSELVGPRQRGVLVSLYEAGIT 165
Cdd:cd17474   55 GVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAgLGPLALTL-IGDLFEGGERAKAMGLYEAALG 133
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 166 VGILLSYALNYALAGtpWGWRHMFGWATAPAVLQSLSLLFLPAGTDETATHKdliplqggeapklgpgrPRYSFLDLFRA 245
Cdd:cd17474  134 LGIAVGPLLGGLLAA--ISWRYPFFLLAALIPVAFLAILFLLPEPKEKAKSS-----------------SATKLRDLKKA 194
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 246 RDNMRGRTTVGLGLVLFQQLTGqpnVLCYASTIfssVGFHGGSSAVLASVGLGAVKVAATLTAMG----LVDRAGRRALL 321
Cdd:cd17474  195 LRGRGLLTFLVSAFLYFFLYFA---FLTYLPFL---LELLYGISPIIIGLLFAGWSVLLALGSLFvgrlLKKRFGARRIL 268
                        250
                 ....*....|....*..
gi 768018403 322 LAGCALMALSVSGIGLV 338
Cdd:cd17474  269 VIGLLLYALSLLLLGFV 285
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
44-332 4.58e-11

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 64.63  E-value: 4.58e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  44 GYELAVISGALLPLQLDFGLSCLEQEFLVGSLLLGALLASLVGGFLIDCYGRKQAILGSNLVLLAGSLTLGLAGSLAWLV 123
Cdd:cd17371   12 GFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 124 LGRAVVGFAISLSSMACCIYVSELVGPRQRGVLVSLYEAGITVGILLSYALNYAL---AGTPWGWRHMFGWATAPAVLQS 200
Cdd:cd17371   92 ILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLfplLPPEIAWRVLFLLGALPALLVL 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 201 LSLLFLPagtdETAthkdlIPLQGGEAPKLGPGRPrySFLDLFRArdNMRGRTTVGLGLVLFQQLTgqpnvlCYASTIFS 280
Cdd:cd17371  172 FIRRFVK----EPP-----QWQAARAARRHFADRP--SLRELFSP--PLLRTTLLASLLATGALGG------YYGITTWL 232
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 768018403 281 SV---GFHG----GSSAVLASVGLGAvkVAATLTAMGLVDRAGRRALLLAGCALMALSV 332
Cdd:cd17371  233 PSyltGERGlsfeGSAGYLVVTILGG--FLGYLAGGFLADRIGRRNNFALFALGSAISI 289
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
86-330 3.98e-10

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 61.81  E-value: 3.98e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  86 GGFLIDCYGRKQAILGSNLVLLAGSLTLGLAGSLAWLVLGRAVVGFAISLSSMACCIYVSELVgPRQRGVLVSLYEAGIT 165
Cdd:COG2807   73 APRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWF-PDRVGLMTGLYTAAMG 151
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 166 VGILLSYALNYALAGTpWGWRHMFGWATAPAVLqsLSLLFLPagtdetathkdLIPLQGGEAPKLGPGRPRYSFLdlfra 245
Cdd:COG2807  152 LGAALAAGLTVPLAAA-LGWRGALAVWALLALL--ALLLWLP-----------LLRRRPAAAAAAPAAASLRSLW----- 212
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 246 rdnmRGRTTVGLGLVLFQQLTGQPNVLCYASTIFSSVGFHGGSSAVLASVgLGAVKVAATLTAMGLVDRAGRRALLLAGC 325
Cdd:COG2807  213 ----RSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLSAATAGLLLSL-FQLAGIPGSLLVPLLADRLGDRRPLLLLL 287

                 ....*
gi 768018403 326 ALMAL 330
Cdd:COG2807  288 GLLGL 292
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
86-207 5.25e-09

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 57.59  E-value: 5.25e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  86 GGFLIDCYGRKQAILGSNLVLLAGSLTLGLAGSLAWLVLGRAVVGFAISLSSMACCIYVSELVGPRQRGVLVSLYEAGIT 165
Cdd:cd17317   45 FGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIVGPKYRSFVGILFGLFWA 124
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 768018403 166 VGILLSYALNYALagTPWGWRHMFgwATAPAVLQSLSLLFLP 207
Cdd:cd17317  125 LGYMLLALLAYLI--RDWRWLQLA--ISLPGLLFLLLLWWLP 162
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
44-189 7.17e-09

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 57.60  E-value: 7.17e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  44 GYELAVISGALLPLQLDFGLSCLEQEFLVGSLLLGALLASLVGGFLIDCYGRKQAILGSNLVLLAGSLTLGLAGSLAWLV 123
Cdd:cd17365   12 GFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLA 91
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 768018403 124 LGRAVVGFAISlSSMACCI-YVSELVGPRQRGVLVSLYEAGITVGILLSYALNYALAGTpWGWRHMF 189
Cdd:cd17365   92 LLRFLTGLGLG-AAMPNAItLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPA-FGWRSVF 156
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
86-207 1.96e-08

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 56.06  E-value: 1.96e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  86 GGFLIDCYGRKQAILGSNLVLLAGSLTLGLAGSLAWLVLGRAVVGFAISLSSMACCIYVSELVGPRQRGVLVSLYEAGIT 165
Cdd:cd17489   51 AGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATT 130
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 768018403 166 VGILLSYALNYALAGTpWGWRHMFGWATAPAVLQSLSLLFLP 207
Cdd:cd17489  131 LAMALGPALGLFLYQH-LGFAVLFIVAAVLALLALLLVFLVK 171
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
86-339 7.83e-08

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 54.47  E-value: 7.83e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  86 GGFLIDCYGRKQAILGSNLVLLAGSLTLGLAGSLAWLVLGRAVVGFAISLSSMACCIYVSELvGPRQRGVLVSLYEA--- 162
Cdd:COG0738   63 AGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAAL-GPETAASRLNLLHAffs 141
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 163 -GITVGILLSYALnyALAGTPWGWRHMFGWATAPAVLqsLSLLFLPAGtdetathkdlIPLQGGEAPKLGPGRPRYSFLd 241
Cdd:COG0738  142 lGALLGPLLGGLL--ILLGLSLSWHLPYLILAVLLLL--LALLFLRSK----------LPEIEEEEEEAAGSAASLKSL- 206
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 242 lfrardnMRGRTTVGLGLVLF-----QQLTGQpnvlcYASTIFSSVgfhGGSSAVLASVGLGAVKVAAT---LTAMGLVD 313
Cdd:COG0738  207 -------LKNPRLLLGGLAIFlyvgaEGAIGD-----WLPLYLKDV---LGLSEATAALGLSLFWGGMTigrFLGGFLLK 271
                        250       260
                 ....*....|....*....|....*.
gi 768018403 314 RAGRRALLLAGCALMALSVSGIGLVS 339
Cdd:COG0738  272 RFGPVRLLRLSALLAAVGLLLALLAP 297
MFS_SLC22A1_2_3 cd17379
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...
87-185 1.17e-07

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340937 [Multi-domain]  Cd Length: 340  Bit Score: 53.51  E-value: 1.17e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  87 GFLIDCYGRKQAILGSNLVLLAGSLTLGLAGSLAWLVLGRAVVGFAISLSSMACCIYVSELVGPRQRGVLVSLYEAGITV 166
Cdd:cd17379   54 GYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFRFLQGLFGKGGWMTGYVLVTEFVGSKYRRTVGIVYQMFFTL 133
                         90
                 ....*....|....*....
gi 768018403 167 GILLSYALNYALagTPWGW 185
Cdd:cd17379  134 GLLILPGIAYFI--PHWRW 150
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
87-159 7.14e-07

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 51.03  E-value: 7.14e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 768018403  87 GFLIDCYGRKQAILGSNLVLLAGSLTLGLAGSLAWLVLGRAVVGF-AISLSSMACCIyVSELVGPRQRGVLVSL 159
Cdd:cd17502   51 GKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIgGGGLMSLAFII-IADLVPPRERGKYQGY 123
MFS_KgtP cd17367
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ...
87-344 1.04e-06

Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340925 [Multi-domain]  Cd Length: 407  Bit Score: 50.76  E-value: 1.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  87 GFLIDCYGRKQAILGSNLVLLAGSLTLGLAGSLA----W----LVLGRAVVGFAISLSSMACCIYVSELVGPRQRGVL-- 156
Cdd:cd17367   61 GRLADRIGRRAALTLSVSLMAAGSLVIAVTPTYAtigiWapiiLLLARLLQGLSVGGEYGTSATYLSEVAPPGRRGFYss 140
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 157 ---VSLYeAGITVGILLSYALNYALAG---TPWGWRHMFGWATAPAVLqslsLLFLPAGTDETathkdliplQGGEAPKL 230
Cdd:cd17367  141 fqyVTLI-GGQLLALGVLLVLQHTLGEdqmAAWGWRIPFLLGGVLAVV----VLWLRRGLEET---------ESFEAIAE 206
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 231 GPGRPRYSFLDLFRARdnmrgrttVGLGLVLFqqLTGQPNVLCYASTIFSS---VGFHGGSSAVLASVGLGAVKVAATLT 307
Cdd:cd17367  207 SNEASAGTLRELRRHP--------RELLLVVG--LTAGGTLAFYTWTTYLQkflVNTAGFSKGDATWITTAALLVFMLLQ 276
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 768018403 308 AMG--LVDRAGRRALLLagcalmalsVSGIGLVSFAVPM 344
Cdd:cd17367  277 PLGgrLSDRIGRRPLLL---------FFGIGGTLATVPL 306
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
87-207 1.29e-06

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 50.65  E-value: 1.29e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  87 GFLIDCYGRKQAILGSNLVLLAGSLTLGLAGSLAWLVLGRAVVGFAISLSSMaCCIYVSELVGPRQRGVLVSLYEAGITV 166
Cdd:cd17504   52 GRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIGGAVFPL-AFALVREEFPPERVPVAQGILSATFGI 130
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 768018403 167 GILLSYALNYALAGTpWGWRHMFgWATAPAVLqsLSLLFLP 207
Cdd:cd17504  131 GAGIGLPLGGWIVQH-LGWRWIF-WTAAPVAV--LLAALVP 167
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
86-234 1.86e-06

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 49.96  E-value: 1.86e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  86 GGFLIDCYGRKQAILGSNLVLLAGSLTLGLAGSLAWLVLGRAVVGFAISLSSMACCIYVSELVGPRQRGVLVSLYEAGIT 165
Cdd:PRK11551  70 GGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVP 149
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 768018403 166 VGILLSYALNYALAGtPWGWRHMF--GWAtAPAVLQSLSLLFLPAGTDETATHKDLIPLQGGEAPKLGPGR 234
Cdd:PRK11551 150 FGGALASVIGVLAAG-DAAWRHIFyvGGV-GPLLLVPLLMRWLPESRAFAQAAGAGKQRAPVLRALFGEGR 218
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
91-207 2.09e-06

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 49.88  E-value: 2.09e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  91 DCYGRKQAILGSNLVLLAGSLTLGLAGSLAWLVLGRAVVGFAIS--LSSMACCIyvSELVGPRQRGVLVSLYEAGITVGI 168
Cdd:cd17323   59 ELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFGSspLAIGAGTI--ADLFTPEERGKAMGVYSLGPLLGP 136
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 768018403 169 LLSyALNYALAGTPWGWRHMFGWATAPA-VLQSLSLLFLP 207
Cdd:cd17323  137 ALG-PIIGGFITQSLGWRWIFWFLAIISgFCLILIFLFLP 175
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
91-331 2.13e-06

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 49.83  E-value: 2.13e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  91 DCYGRKQAILGSNLVLLAGSLTLGL------AGSLAW--LVLGRAVVGFAISLSSMACCIYVSELVGPRQRGVLVSLYEA 162
Cdd:cd17369   69 DRIGRKKTLVLTLLLMGIATFLIGLlptyaqIGILAPilLVLLRLLQGLALGGEWGGAVLMAVEHAPPKRRGFYGSFPQL 148
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 163 GITVGILLSYALNYALAGTP-------WGWRHMFgWATAPAVLQSLsllFLPAGTDETATHKDLipLQGGEAPKLgpgrp 235
Cdd:cd17369  149 GAPVGLLLATGVFLLLSALLsdeaflsWGWRIPF-LLSAVLVAVGL---YIRLRLEETPVFRRA--KEAGQVVRA----- 217
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 236 rysflDLFRARDNMRGRTTVGLGLVLFQqltgqpNVLCYASTIFS---SVGFHG-GSSAVLASVGLGAVKVAATLTAMG- 310
Cdd:cd17369  218 -----PLVEVLRRHWRALLLAIGLRLAE------NVLFYLFTTFAlsyATQTLGvDRSTVLLAVLIASVVAAITIPLFGw 286
                        250       260
                 ....*....|....*....|.
gi 768018403 311 LVDRAGRRALLLAGCALMALS 331
Cdd:cd17369  287 LSDRVGRRPVYLAGALLAALF 307
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
86-212 2.34e-06

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 49.87  E-value: 2.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  86 GGFLIDCYGR--KQAILGSNLVLLAGSLTLGLAGSLAWLVLGRAVVGFAISLSSMACCIYVSELVGPRQRGVLVSL-YEA 162
Cdd:COG2271  236 GGWLSDRLGRrrKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLvNTF 315
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 768018403 163 GITVGILLSYALNYALAGTpwGWRHMFGWATAPAVLQSLSLLFLPAGTDE 212
Cdd:COG2271  316 GFLGGALGPLLVGYLLDAT--GYQAAFLLLAALALLAALLALLLLRETRK 363
PRK03893 PRK03893
putative sialic acid transporter; Provisional
86-218 3.05e-06

putative sialic acid transporter; Provisional


Pssm-ID: 179668 [Multi-domain]  Cd Length: 496  Bit Score: 49.70  E-value: 3.05e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  86 GGFLI----DCYGRKQAILGSNLVLLAGSLTLGLAGSLAWLVLGRAVVGFAISLSSMACCIYVSELVGPRQRGVLVSLYE 161
Cdd:PRK03893  71 GGLLLgamgDRYGRRLAMVISIVLFSVGTLACGFAPGYWTLFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLI 150
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 768018403 162 AGITVGILLSyALNYALAGTPWGWRHMFGWATAPAVLQSLSLLFLPAGTDETATHKD 218
Cdd:PRK03893 151 SGFSIGAVVA-AQVYSLVVPVWGWRALFFIGILPIIFALWLRKNLPEAEDWKEKHAG 206
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
87-206 6.03e-06

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 48.37  E-value: 6.03e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  87 GFLIDCYGRKQAILGSNLVLLAGSLTLGLAGSLAWLVLGRAVVGF-AISLSSMACciyVSELVGPRQRGVLVSLYEAGIT 165
Cdd:cd17472   53 GLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSgAISSVVMAL---LADLTREENRTKAMALIGASIG 129
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 768018403 166 VGILLSYALNYALAGtPWGWRHMFgWATapAVLQSLSLLFL 206
Cdd:cd17472  130 IAFAISMVLGPLLAA-HLGVSGLF-LIT--AILSLVSLLIL 166
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
48-198 7.42e-06

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 47.95  E-value: 7.42e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  48 AVISGALLPLQLDFGLSCLEQEFLVGSLLLGALLASLVGGFLIDCYGRKQAILGSNLVLLAGSLTLGLAGSLAWLVLGRA 127
Cdd:cd17319   20 VNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRF 99
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 768018403 128 VVGFAISLSSMACCIYVSELVGPRQRGVLVSLYEAGITVGILLSYALNYALAGTpWGWRHMFGWATAPAVL 198
Cdd:cd17319  100 LLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLL-FGWRWAFIIEGLLGLL 169
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
87-331 9.59e-06

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 47.65  E-value: 9.59e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  87 GFLIDCYGRKQAILGSNLVLLAGSLTLGLAGSLAWLVLGRAVVGFA-ISLSSMACCIYVSELVGPRQRGVLVSLYEAGIT 165
Cdd:cd17355   59 GRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGgAGTLAAVAFATVAAWWFERRRGLALGILTAGGG 138
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 166 VGILLSYALNYALAGTpWGWRHMFGWATAPAVLQSLSLLFLPagtdetatHKDLIPLQGGEAPKLGPGRPRYSFLDLFRA 245
Cdd:cd17355  139 LGSLVFLPLGAALIEA-FGWRTALLVLALLALLVLVPVLLLL--------RRRPADLALRAYDDASPASPGSTLKEALRS 209
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 246 RDNMR---GRTTVGLGLVLFQQltgqpnvlcyasTIFSSVGFHGGSSAVLASVG--LGAVKVAATLTAMGLVDRAGRRAL 320
Cdd:cd17355  210 ASFWLlalAFFLCGFAVVGLIV------------HLVPYLADRGISPAAAAVALalIGLFNIVGRLLSGWLGDRYSPRRL 277
                        250
                 ....*....|.
gi 768018403 321 LLAGCALMALS 331
Cdd:cd17355  278 LAASYALRALG 288
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
87-186 9.77e-06

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 48.01  E-value: 9.77e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  87 GFLIDCYGRKQAILGSNLVLLAGSLTLGLAGSLAWLVLGRAVVGFAISLSSMACCIyVSELVGPRQRGVLVSLYEAGITV 166
Cdd:cd06179   53 GRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALIGIGAGTQGLGAAV-ASELVPNKYRGLVQGVVNLVASP 131
                         90       100
                 ....*....|....*....|.
gi 768018403 167 GILLSYALNYALA-GTPWGWR 186
Cdd:cd06179  132 GSALGPLIAGALVeANAAGWR 152
MFS_SVOP_like cd17372
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...
87-210 1.48e-05

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340930 [Multi-domain]  Cd Length: 367  Bit Score: 47.14  E-value: 1.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  87 GFLIDCYGRKQAILGSNLVLLAGSLTLGLAGSLAWLVLGRAVVGFAISLSSMACCIYvSELVGPRQRGVLVSLYEAGITV 166
Cdd:cd17372   55 GIVSDKYGRRKGLIISALWTFYAGFLSAFAPNYMWLIILRCLVGLGLGGGPQLASWY-LEFLPAKSRGTWMVLFSVFWTV 133
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 768018403 167 GILLSYALNYALAGTpWGWRHMFGWATAPAVLQSLSLLFLPAGT 210
Cdd:cd17372  134 GTIFEASLAWLVMPR-LGWRWLLAFSSVPSSLLLVFYRWTPKTT 176
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
86-339 1.61e-05

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 47.22  E-value: 1.61e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  86 GGFLIDCYGRKQAILGSNLVLLAGSLTLGLAGSLAWLVLGRAVVGFAISLSSMACCIYVSELVGPRQRGVLVSLYEAGIT 165
Cdd:cd17329   55 GGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAIN 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 166 VGILLSyalnyALAGTpWGWRHMFGWAT-APAVLQSLSLLFLPAGTDETATHKdliplqgGEAPKLGPGRPRYSFLdlfr 244
Cdd:cd17329  135 LGVAIG-----PLLGG-LLLLYSFRLLFlAAAVLFLLAALVLLFLLPETRPKR-------RAAEKTEILRGYKIVL---- 197
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 245 aRDNMrgRTTVGLGLVLFQQLTGQPNVlcyASTIFSSVGFHGGSSAVLASVGL-GAVKVAATLTAMGLVDRAGRRALLLA 323
Cdd:cd17329  198 -RDRA--FLLFLLASFLISLIYFQLES---TLPVYVVEILGLGESLLGLLLALnALLIVLLQFPVARLVERFRLRKILMI 271
                        250
                 ....*....|....*.
gi 768018403 324 GCALMALSVSGIGLVS 339
Cdd:cd17329  272 GILLFAIGFAVLAFAN 287
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
86-168 1.65e-05

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 46.89  E-value: 1.65e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  86 GGFLIDCYGRKQAILGSNLVLLAGSLTLGLAGSLAWLVLGRAVVGFAISLSSMACCIYVSELVGPRQRGVLVSLYEAGIT 165
Cdd:COG2814  263 AGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFF 342

                 ...
gi 768018403 166 VGI 168
Cdd:COG2814  343 LGG 345
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
104-338 3.76e-05

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 46.05  E-value: 3.76e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 104 LVLLAGSLTLGLAGSLAWLVLGRAVVGFAISLSSMACCIYVSELVG-PRQRGVLVSLYEAGITVGILLSYAL-----NYA 177
Cdd:COG2211   95 FVLLFTAPDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPdYEERTRLSSWRFAFAGLGGLLASVLppplvAAF 174
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 178 LAGTPWGWRHMFGWATAPAVLqslSLLFLPAGTDETAThkdliplqggeaPKLGPGRPRYSFLDLFRARDNMRgrttvgL 257
Cdd:COG2211  175 GGDAALGYRLTALIFAVLGLL---AFLLTFFGTKERPV------------PEEEKVSLKESLKALLKNRPFLL------L 233
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 258 GLVLFQQLTGqpNVLCYASTIF---SSVGFHGGSSAVLASVGLGAVkVAATLTAMGLVDRAGRRALLLAGCALMALSVSG 334
Cdd:COG2211  234 LLAYLLFFLA--LALVAALLLYyfkYVLGLSAALVGLLLALYFLAA-LLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLL 310

                 ....
gi 768018403 335 IGLV 338
Cdd:COG2211  311 LFFL 314
MFS_CitA cd17368
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ...
87-333 8.69e-05

Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340926 [Multi-domain]  Cd Length: 407  Bit Score: 45.06  E-value: 8.69e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  87 GFLIDCYGRKQAILGSNLVLLAGSL---------TLGLAGSLAwLVLGRAVVGFAISLSSMACCIYVSELVGPRQRGVLV 157
Cdd:cd17368   61 GAYADRIGRKPAMTLTLAIMALGTLlialaptyaTIGIAAPLL-VLLARLLQGFAAGGEVGGVTAYLVEAAPPGRRGFYT 139
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 158 SLYEAG----ITVGILLSYALNYAL---AGTPWGWRHMF--GWATAPAvlqslsLLFLPAGTDETathkdliplqggeap 228
Cdd:cd17368  140 SWQSASqqvaIVAGALVGYLLSLTLtaeALAEWGWRIPFfiGLLIIPL------GLWLRRSLEET--------------- 198
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 229 KLGPGRPRYSFLDLFRARdNMRGRTTVGLGLVLFQQLTGQPNVLCYASTIFSSVGFH-GGSSAVLASVGLGAVKVAATLT 307
Cdd:cd17368  199 EAFLERKARPTRRELFAL-LANNRRIILLGMLLVAGSTVTFYFTTVYTPTYAKTVLGlSARDSFLVTLLAGVANFIWAPL 277
                        250       260
                 ....*....|....*....|....*.
gi 768018403 308 AMGLVDRAGRRALLLaGCALMALSVS 333
Cdd:cd17368  278 GGALSDRIGRRPVLL-VITLAALVTL 302
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
87-186 1.40e-04

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 44.15  E-value: 1.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  87 GFLIDCYGRKQAILGSNLVLLAGSLTLGLAGSLAWLVLGRAVVGFAISLSSMACCIYVSELVGPRQRGVLVSLYEAGITV 166
Cdd:cd17328   55 GYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPL 134
                         90       100
                 ....*....|....*....|
gi 768018403 167 GILLSYALNYALAGTPWGWR 186
Cdd:cd17328  135 GSGLGYVVGGLVAQATGGWR 154
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
87-339 1.93e-04

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 43.72  E-value: 1.93e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  87 GFLIDCYGRKQAILGSNLVLLAGSLTLGLAGSLAWLVLGRAVVGFAISL---SSMAcciYVSELVGPRQRGVLVSLYEAG 163
Cdd:cd17503   52 GWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVlipLAQT---ILLRIYPPEKRGAAMGLVGLV 128
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 164 ITVGILLSYALNYALAGTpWGWRHMFgWATAPAVLqsLSLLFLPagtdetathkdLIPlqggeapklgpgrprysfLDLF 243
Cdd:cd17503  129 ILLAPAIGPTLGGWLTDN-LSWRWIF-YINLPIGI--LALLLAP-----------LLD------------------LRLF 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 244 RARDnmrgrTTVG-LGLVLFQQLTGQPNVLC--YASTIFSSVGFHGGssAVLASVGLGAVkVAATLTAMgLVDRAGRRAL 320
Cdd:cd17503  176 KDRN-----FTLGlLLSFLLGLGLFGAMFLLplYLQNVLGYSAFESG--LVLAPGGLASA-ILSPLVGR-LLDKFGPRLL 246
                        250
                 ....*....|....*....
gi 768018403 321 LLAGCALMALSVSGIGLVS 339
Cdd:cd17503  247 LLAGLLLLALGTLLLAFLT 265
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
86-344 2.08e-04

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 43.76  E-value: 2.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  86 GGFLIDCYGRKQAILGSNLVLLAGSLTLGLA-----GSLAWLVLGRAVVGFAISLSSMACCIYVSELVGPRQRGVLVSLY 160
Cdd:cd06173   54 AGVLADRFDRRRLLILADLLRALLAAVLALLallgsLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALN 133
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 161 EAGITVGILLSYALNYALAGTpWGWRHMFGWATAPAVLQSLSLLFLPAGTDETATHKDLIPLQGGEApklgpgrprysFL 240
Cdd:cd06173  134 SLATQLARIIGPALGGLLVAL-LGPGGAFAINALSFLLSALLLLFIRRPPPAAPGESSSLLLRDLRE-----------GL 201
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 241 DLFRARdnmRGRTTVGLGLVLFQQLTGQPNVLcyaSTIFSSVGFHGGSSA---VLASVGLGAvkVAATLTAMGLVDRAGR 317
Cdd:cd06173  202 RYLRRS---PLLRLLLLALALFALLGGALTVL---LPLLAKEVLGGGAAGyglLLAAFGVGA--LLGALLLGRLSKRRRR 273
                        250       260
                 ....*....|....*....|....*..
gi 768018403 318 RALLLAGCALMALSVSGIGLVSFAVPM 344
Cdd:cd06173  274 GRLLLIGALLLGLALLVLGLSPSLWLL 300
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
87-207 2.31e-04

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 43.30  E-value: 2.31e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  87 GFLIDCYGRKQAILGSNLVLLAGSLTLGLAGSLAWLVLGRAVVGFAISLSSMACCIYVSELVGPRQRGVLVSLYEAGITV 166
Cdd:cd17370  255 GRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGI 334
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 768018403 167 GILLSyalnYALAGTPWgwrHMFGWATA---PAVLQSLSLLFLP 207
Cdd:cd17370  335 GWLLA----SLIAGYLW---DLISPSAAflfSAVLALIALLLLL 371
MFS_MosC_like cd17393
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ...
83-341 2.38e-04

Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340951 [Multi-domain]  Cd Length: 373  Bit Score: 43.40  E-value: 2.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  83 SLVGGFLIDCYGRKQAILGSNLVLLAGSLTLGLAGSLAWLVLGRAVVGFAISLSSMACCIYVSELVGPRQRGVLVSL--- 159
Cdd:cd17393   51 MPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVPALALALFLFGAANGALDVAMNAQGVAVERAYGRPIMSSLham 130
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 160 YEAGITVGILLSYALnyALAGTPWGWrHMFGWATAPAVLQSLSLLFLPAGTDETAthkdliplqggEAPKLGPGRPRYSF 239
Cdd:cd17393  131 WSLGGLAGALLGAAA--IGAGVSPGV-HLLAAAVLLLLAALVAIRALLPGTGEAA-----------EDRPDGAGKPGFLL 196
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 240 ldlfrardnmRGRTTVGLGLVLFQQLTGQPNVLCYASTIFSSVgfhGGSSAVLASVGLGAVKVAAT---LTAMGLVDRAG 316
Cdd:cd17393  197 ----------PNRLLLLLGLLALAAALAEGAAADWSALYLRDV---LGASAALAALGYAVFSLAMTvgrLFGDRLVDRFG 263
                        250       260
                 ....*....|....*....|....*
gi 768018403 317 RRALLLAGcalMALSVSGIGLVSFA 341
Cdd:cd17393  264 DVAVLRAG---ALLAALGLLLALLA 285
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
89-174 3.46e-04

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 42.93  E-value: 3.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  89 LIDCYGRKQAILGSNLVLLAGSLTLGLAGSLAWLVLGRAVVGFAISLSSMACCIYVSELVGPRQRGVLVSLYEAGITVGI 168
Cdd:cd17477   54 LIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGF 133

                 ....*.
gi 768018403 169 LLSYAL 174
Cdd:cd17477  134 ALGPLL 139
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
86-170 3.46e-04

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 42.95  E-value: 3.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  86 GGFLIDCYGRKQAILGSNLVLLAGSLTLGLAGSLAWLVLGRAVVGFAISLSSMACCIYVSELVGPRQRGVLVSLYEAGIT 165
Cdd:cd17325  255 AGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFS 334

                 ....*
gi 768018403 166 VGILL 170
Cdd:cd17325  335 LGMVL 339
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
87-198 3.64e-04

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 42.97  E-value: 3.64e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  87 GFLIDCYGRKQAILGSNLVLLAGSLTLGLAGSLAWLVLGRAVVGFAISLSSMACCIYVSELVGPRQRGVLVSLYEAGITV 166
Cdd:cd17489  248 GKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDL 327
                         90       100       110
                 ....*....|....*....|....*....|..
gi 768018403 167 GILLSYALNYALAGTpWGWRHMFGWATAPAVL 198
Cdd:cd17489  328 GIGLGGLLLGLVAEL-FGYRAMFLLAAVVVLL 358
MFS_ProP cd17366
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ...
87-344 4.39e-04

Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340924 [Multi-domain]  Cd Length: 377  Bit Score: 42.73  E-value: 4.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  87 GFLIDCYGRkQAILGSNLVLLAGS-LTLGLAGSLA----W----LVLGRAVVGFAISLSSMACCIYVSELVGPRQRGVLV 157
Cdd:cd17366   61 GPLGDKYGR-QKVLAITIILMAAStFCIGLLPTYAtigvWapilLLLARMVQGFSTGGEYGGAATFVAEYAPDRKRGFLG 139
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 158 SLYE----AGITVGILLSYALNYALAGT---PWGWRHMFgwatapavlqslsLLFLPAGtdetathkdLIPLQggeapkl 230
Cdd:cd17366  140 SWLEfgtlAGFILGAGLVTLLTLLLTEAqmlDWGWRIPF-------------LIAAPLG---------LVGLY------- 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 231 gpgrprysfldlfrardnMRGRTTVGLGLVLFQQLTGQpNVLCYASTIFSSV-GFHGGSSAVLASVGLGAVKVAATLTAM 309
Cdd:cd17366  191 ------------------LRRPLLICIGLVLVFNVTNY-MLLSYMPSYLEETlGYSETHGLLVIIIIMVTMLVLQPFLGR 251
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 768018403 310 gLVDRAGRRALLLAGCAlmalsvsgiGLVSFAVPM 344
Cdd:cd17366  252 -LSDRVGRKPVYAAGLA---------GLLVLAVPA 276
MFS_YjiJ cd06180
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ...
86-332 4.75e-04

Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340869 [Multi-domain]  Cd Length: 371  Bit Score: 42.29  E-value: 4.75e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  86 GGFLIDCYGRKQAILGSNLVLLAGSLTLGLAGSLAWLVLGRAVVGFAISLSSMACCIYVSELVGPRQRGVLVSLYEAGIT 165
Cdd:cd06180   54 ASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLALRFLAGAASAFVFVFGSNLVLHHATAAGRGHLIGLLFAGVG 133
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 166 VGILLSYALNYALAGTPWGWRHMFGWATAPAVLQSLsLLFLPAGTdetathkdliplqggeapklGPGRPRYSFLDLFRA 245
Cdd:cd06180  134 LGIALSGLLVPAGLGGGLSWRAGWLALALLSAVLLL-LSFLLLRR--------------------GPSAPTEASAAESAP 192
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 246 RDNMR-GRTTVGLGLVLFQQLTgqpnvlcYASTIFSSVGFHGGSSAVLAS----VGLGAvkVAATLTAMGLVDRAGRRAL 320
Cdd:cd06180  193 GLNRPlWRLALAYGLFGFGYII-------TATFLPLIARETGAGSLLAGLlwslFGLAA--VPSCFLWGALSDRWGTRRA 263
                        250
                 ....*....|..
gi 768018403 321 LLAGCALMALSV 332
Cdd:cd06180  264 LAANLLVQAVGV 275
MFS_SVOPL cd17442
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; ...
87-210 5.94e-04

Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) or SVOP-like protein is a transporter-like protein that shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. It belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341000 [Multi-domain]  Cd Length: 375  Bit Score: 42.10  E-value: 5.94e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  87 GFLIDCYGRKQAILGSNLVLLAGSLTLGLAGSLAWLVLGRAVVGFAISLSSMAcCIYVSELVGPRQRGVLVSLYEAGITV 166
Cdd:cd17442   57 GLLADRYGRWKILLLSFVWGAYFSLLTSFAPSYIWFVFLRCMVGCGVSGHSQG-LIIKTEFLPTKYRGYMLPLSQIFWLA 135
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 768018403 167 GILLSYALNYALAGTpWGWRHMFGWATAPAVLQSLSLLFLPAGT 210
Cdd:cd17442  136 GSLLIIGLASVVIPT-LGWRWLIRFASIPGIILIVVFKFIPRTT 178
MFS_PhT cd17364
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ...
87-337 8.02e-04

Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340922 [Multi-domain]  Cd Length: 389  Bit Score: 41.88  E-value: 8.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  87 GFLIDCYGRKQAILGSNLVLLAGSLTLGLA------GSLAWLVLGRAVVGFAIS----LSSMAcciyVSELVGPRQRGVL 156
Cdd:cd17364   60 GFLGDRFGRKRVYGVELIIMIIGTILSALSpgstplGVMGWLIFFRFLLGIGIGgdypLSATI----MSEYANKKRRGAL 135
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 157 VSLYEAGITVGILLSYALNYALAGTPWG-------------WRHMFGWATAPAvlqsLSLLFLpagtdetatHKDLIPLQ 223
Cdd:cd17364  136 IAAVFAMQGFGILAGAIVTLILSAIFEHplpagtyhhadlvWRIVLGLGAIPA----LSVLYF---------RKHLLGTA 202
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 224 GGeapklgpgrprYSFLDLfrardnmrgrTTVGLGLvlfqqltgqpnvlcYASTIFSSVGFHGG--------SSAVLASV 295
Cdd:cd17364  203 GT-----------WFLLDI----------AFYGQNL--------------FQSTIISAIGFSKTmnayqelfNIAVGQLI 247
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 768018403 296 GLGAVKVAATLTAMGLVDRAGRRALLLAGCALMALSVSGIGL 337
Cdd:cd17364  248 IALAGTVPGYWFTVFLIDRIGRKKIQMMGFFGMTIFLLILAG 289
MFS_SVOP cd17441
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ...
87-207 9.77e-04

Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340999 [Multi-domain]  Cd Length: 372  Bit Score: 41.34  E-value: 9.77e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  87 GFLIDCYGRKQAILGSNLVLLAGSLTLGLAGSLAWLVLGRAVVGFAISLSSMACCIYvSELVGPRQRGVLVSLYEAGITV 166
Cdd:cd17441   55 GNISDQYGRKTGLKISVLWTLYYGILSAFAPIYSWILVLRGLVGFGIGGVPQSVTLY-AEFLPMKSRAKCILLIEVFWAL 133
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 768018403 167 GILLSYALNYALAGTpWGWRHMFGWATAPAVLQSLSLLFLP 207
Cdd:cd17441  134 GTVFEVLLAVFVMPT-LGWRWLLILSALPLLIFAVLCFWLP 173
MFS_2 pfam13347
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ...
99-353 1.61e-03

MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.


Pssm-ID: 433134 [Multi-domain]  Cd Length: 427  Bit Score: 40.76  E-value: 1.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403   99 ILGSNLVLLAGSLTLGLAGSLAWLVLGRAVVGFAISLSSMACCIYVSEL-VGPRQRGVLVSLYEAGITVGILLSYALNYA 177
Cdd:pfam13347  77 ILAVSFILLFTPPELGRAPLFIWLLATYILLRIAYTFFEIPYWSLGPELtRDYDERTSLTSYRSFFSVGGGLLAAALAFP 156
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  178 LAGTPWGWRH----MFGWATAPAVLQSLSLLFLPAGTDETATHKDLIPLQGGEAPKLGPGrprysFLDLFRARDNMrgrt 253
Cdd:pfam13347 157 LVLILGGTGLerkgYRIFALIGAVLMLLGVIITAAGTKERVSMRSKEDTGQKEAGSLLDM-----LKEVFRNRAFL---- 227
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  254 tVGLGLVLFQQLTGqpnVLCYASTIF---SSVGFHGGSSAVLASVGLGAvkVAATLTAMGLVDRAGRRALLLAGcalMAL 330
Cdd:pfam13347 228 -ILLASFLLAALAM---GVLNGLLLYyfrYVLGNGFAASAFPLVFTIGA--LLGIPLWPPLAKRIGKKNTYILG---ALI 298
                         250       260
                  ....*....|....*....|...
gi 768018403  331 SVSGIGLVSFAVPMDSGPSCLAV 353
Cdd:pfam13347 299 TIAGFALALLLGPNNTLLFLVLY 321
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
86-189 2.38e-03

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 40.23  E-value: 2.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  86 GGFLIDCYGRKQAILGSNLVLLAGSLTLGLAGSLAWLVLGRAVVGF---AISLSSMAcciYVSELVGPRQRGVLVSLYEA 162
Cdd:cd17321   51 AGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIgaaAIMPASLA---LIAATFPGERRGRALGLWGA 127
                         90       100
                 ....*....|....*....|....*..
gi 768018403 163 GITVGILLSYALNYALAGTpWGWRHMF 189
Cdd:cd17321  128 VVGIGAALGPLLGGLLLEL-FGWRWIF 153
PRK10642 PRK10642
proline/glycine betaine transporter ProP;
87-332 2.44e-03

proline/glycine betaine transporter ProP;


Pssm-ID: 182611 [Multi-domain]  Cd Length: 490  Bit Score: 40.46  E-value: 2.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  87 GFLIDCYGRkQAILGSNLVLLAGS-LTLGLAGSLA----W----LVLGRAVVGFAISLSSMACCIYVSELVGPRQRGVLV 157
Cdd:PRK10642  78 GMLGDKYGR-QKILAITIVIMSIStFCIGLIPSYAtigiWapilLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMG 156
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 158 SLYE----AGITVG----ILLSYALNYAlAGTPWGWRHMFGWATAPAVLQslslLFLPAGTDETATHKDLIPLQGGEAPK 229
Cdd:PRK10642 157 SWLDfgsiAGFVLGagvvVLISTIVGEA-NFLDWGWRIPFFIALPLGIIG----LYLRHALEETPAFQQHVDKLEQGDRE 231
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 230 LGPGRPRYSFLDLfrARDNMRGrTTVGLGLVLFQQLTgQPNVLCYASTIFS-SVGF---HGGSSAVLASVGLGAVKvaat 305
Cdd:PRK10642 232 GLQDGPKVSFKEI--ATKHWRS-LLTCIGLVIATNVT-YYMLLTYMPSYLShNLHYsedHGVLIIIAIMIGMLFVQ---- 303
                        250       260
                 ....*....|....*....|....*....
gi 768018403 306 lTAMGLV-DRAGRRALLLAGC-ALMALSV 332
Cdd:PRK10642 304 -PVMGLLsDRFGRRPFVILGSvALFVLAI 331
MFS_NIMT_CynX_like cd17339
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ...
94-216 3.90e-03

2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340897 [Multi-domain]  Cd Length: 374  Bit Score: 39.48  E-value: 3.90e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  94 GRKQAILGSNLVLLAGSLtLGLAGSLAWLVLGRAVVGFAISLSSMACCIYVSElVGPRQRGVLVSLYEAGITVGILLSYA 173
Cdd:cd17339   62 GLERTLLLALLLLAAGIL-LRSLGGIALLFLGTALAGAGIAVGNVLLPSLIKR-DFPRRVGLMTGLYTTSMNLGAALASG 139
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 768018403 174 LNYALA-GTPWGWRHMFGWATAPAVLQSLSLLFLPAGTDETATH 216
Cdd:cd17339  140 LSVPLAqALGGGWRGALAIWALPALLALLIWLPQLRRRKRAAAA 183
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
87-344 4.20e-03

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 39.48  E-value: 4.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  87 GFLIDCYGRKQAILGSNLVLLAGSLTLGLAGSLAWLVLGRAVVGFAISLsSMACCI-YVSELVGPRQRGVLVSLYEAGIT 165
Cdd:cd17473   56 GWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAG-IMTLATaLIGDYFEGEERAKMLGLQSAAMS 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 166 VGILLSYALNYALAGtpWGWRHMFGWATAPAVLQSLSLLFLPAGTDETATHKDLIPLQGGEAPKlgpgrprysfldlfra 245
Cdd:cd17473  135 LGGVVFLLLGGALAE--IGWRAPFLVYLLALPVLILVLLFLPEPARKSKSAASPGAATAAALPW---------------- 196
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 246 rdnmrGRTTVGLGLVLFQQltgqpnVLCYASTIFSS--VGFHGGSSAVLASVGLGAVKVAATLTAMG---LVDRAGRRAL 320
Cdd:cd17473  197 -----KRVLPIYFLAFLAM------LLFYVIPIQLPflLQERGGGSAALIGLALAIASLAGAIGALLfgrLKRRLGKRRL 265
                        250       260
                 ....*....|....*....|....
gi 768018403 321 LLAGCALMALSVSGIGLVSFAVPM 344
Cdd:cd17473  266 LAIGFALMALGFLLLALASGLWVV 289
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
87-344 5.25e-03

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 39.10  E-value: 5.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  87 GFLIDCYGRKQAILGSNLVLLAGSLTLGLAGSLAWLVLGRAVVGFAISLSSMACCIYVSELVGPRQRGVLVSLYEAGITV 166
Cdd:cd17320   55 GPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAI 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 167 GILLSYALNYALAgTPWGWRHMFGWATAPAVLQS-LSLLFLPagtdETATHKDLIPLqggeapklgPGRPRYSFLDLFRA 245
Cdd:cd17320  135 APALAPLLGGLLL-LFFGWRAIFVFLALLGLLLLlLVLLFLP----ETLPEEKRKPL---------LSSLLRAYKRVLKN 200
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403 246 RDNMRGRTTVGLGL-VLFQQLTGQP----NVLCYASTIFSSVGFHGGSSAVLASVGLGavKVAATLTAMGLVdragRRAL 320
Cdd:cd17320  201 RRFLGYALALGLSFaGLFAYLAAAPfiyiEQLGLSPAQFGLLFALNAIALILGSLLNG--RLVRRFGPRRLL----RLGL 274
                        250       260
                 ....*....|....*....|....*...
gi 768018403 321 LLAGCALMALSVSGI----GLVSFAVPM 344
Cdd:cd17320  275 LLLLAAALVLLLAALlgglSLWPLVAPL 302
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
86-189 5.80e-03

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 39.14  E-value: 5.80e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  86 GGFLIDCYGRKQAILGSnlVLLAGSLTL----GLAGSLAWLVLGRAVVGFAISLSSMACCIYVSELVGPRQRGVLVSLYE 161
Cdd:cd17318   76 GGYLAEKYGAKRVLGYS--ILITALLTLltplAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAY 153
                         90       100
                 ....*....|....*....|....*...
gi 768018403 162 AGITVGILLSYALNYALAGTpWGWRHMF 189
Cdd:cd17318  154 SGSQFGTVIAMPLSGFLCES-LGWPSIF 180
MFS_OCT_plant cd17378
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ...
94-207 6.06e-03

Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340936 [Multi-domain]  Cd Length: 342  Bit Score: 38.88  E-value: 6.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  94 GRKQAILGSNLVLLAGSLTLGLAGSLAWLVLGRAVVGFAISLSSMACCIYVSELVGPRQRGVLVSLYEAGITVGILLSYA 173
Cdd:cd17378   62 GRKNLLFLSCLLMALSGIATAFSPNYWVYAFLRFLTGFGRSGIGTCALVLATEPVGPKWRGQVGMSTFFFFVLGFMSLPG 141
                         90       100       110
                 ....*....|....*....|....*....|....
gi 768018403 174 LNYaLAGTPwgWRHMFGWATAPAVLQSLSLLFLP 207
Cdd:cd17378  142 IAY-LNGSS--WRVLYFWTSIPALIYCILVYLFA 172
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
87-189 7.88e-03

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 38.90  E-value: 7.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403   87 GFLIDCYGRKQAILGSNLVLLAGSLTLGLAGSLAWLVLGRAVVGF---AISLSSMACciyVSELVGPRQRGVLVSLYEAG 163
Cdd:TIGR00711  58 GWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLELMIIFRVIQGFgggPLIPLSFST---LLNIYPPEKRGRAMAIWGLT 134
                          90       100
                  ....*....|....*....|....*.
gi 768018403  164 ITVGILLSYALNYALAGTpWGWRHMF 189
Cdd:TIGR00711 135 VLVAPALGPTLGGWIIEN-YHWRWIF 159
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
83-205 9.98e-03

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 38.30  E-value: 9.98e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018403  83 SLVGGFLIDCYGRKQAILGSNLVLLAGSLTLGLAGSLAWLVLGRAVVGFAISLSSMACCIYVSELvGPRQRGVLVSLYEA 162
Cdd:cd17324  251 SPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRL-APEARGLASSLYLA 329
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 768018403 163 GITVGILL-SYALNYALAGTPWgwrHMFGWATAPAVLQSLSLLF 205
Cdd:cd17324  330 AYNLGGALgAALGGLVLDHGGW---AGVGWVGAALLLLALLLAL 370
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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