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Conserved domains on  [gi|768023312|ref|XP_011528165|]
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transport and Golgi organization protein 2 homolog isoform X5 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TANGO2 super family cl01315
Transport and Golgi organization 2; In eukaryotes this family is predicted to play a role in ...
 55-167 1.24e-41

Transport and Golgi organization 2; In eukaryotes this family is predicted to play a role in protein secretion and Golgi organization. In plants this family includes Swiss:A9X6Y0, which is involved in water permeability in the cuticles of fruit. Swiss:P54797 has been found to be expressed during early embryogenesis in mice. This protein contains a conserved NRDE motif. This gene has been characterized in Drosophila melanogaster and named as transport and Golgi organization 2, hence the name Tango2.


The actual alignment was detected with superfamily member pfam05742:

Pssm-ID: 470157  Cd Length: 255  Bit Score: 141.63  E-value: 1.24e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023312   55 GELVTHFLTTDVDSLSYLKKVSMEGHLYNGFNLIAADLSTAKGdvICYYGNRGEPDPIVLTPGTYGLSNALLETPWRKLC 134
Cdd:pfam05742  88 GLLVNDFLTSNPDPEEYLEELAKEADKYNGFNLLVGDLNGSKS--LAYISNRGNPTPDQLSPGIHGLSNSLLDSPWPKVE 165

                          90       100       110
                  ....*....|....*....|....*....|...
gi 768023312  135 FGKQLFLEAVERSQALPKDVLIASLLDVLNNEE 167
Cdd:pfam05742 166 RGKRLFEELVEESVEDSEDQLIEELFDLLSDDT 198
 
Name Accession Description Interval E-value
TANGO2 pfam05742
Transport and Golgi organization 2; In eukaryotes this family is predicted to play a role in ...
 55-167 1.24e-41

Transport and Golgi organization 2; In eukaryotes this family is predicted to play a role in protein secretion and Golgi organization. In plants this family includes Swiss:A9X6Y0, which is involved in water permeability in the cuticles of fruit. Swiss:P54797 has been found to be expressed during early embryogenesis in mice. This protein contains a conserved NRDE motif. This gene has been characterized in Drosophila melanogaster and named as transport and Golgi organization 2, hence the name Tango2.


Pssm-ID: 461729  Cd Length: 255  Bit Score: 141.63  E-value: 1.24e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023312   55 GELVTHFLTTDVDSLSYLKKVSMEGHLYNGFNLIAADLSTAKGdvICYYGNRGEPDPIVLTPGTYGLSNALLETPWRKLC 134
Cdd:pfam05742  88 GLLVNDFLTSNPDPEEYLEELAKEADKYNGFNLLVGDLNGSKS--LAYISNRGNPTPDQLSPGIHGLSNSLLDSPWPKVE 165

                          90       100       110
                  ....*....|....*....|....*....|...
gi 768023312  135 FGKQLFLEAVERSQALPKDVLIASLLDVLNNEE 167
Cdd:pfam05742 166 RGKRLFEELVEESVEDSEDQLIEELFDLLSDDT 198
Tango2 COG3332
Uncharacterized stress-responsive protein, TANGO2 (Transport and Golgi organisation 2) family, ...
 55-181 1.16e-25

Uncharacterized stress-responsive protein, TANGO2 (Transport and Golgi organisation 2) family, contains NRDE motif [General function prediction only];


Pssm-ID: 442561  Cd Length: 257  Bit Score: 99.95  E-value: 1.16e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023312  55 GELVTHFLTTDVDSLSYLKKVSMEGHLYNGFNLIAADLSTAkgdviCYYGNRGEPDPIVLTPGTYGLSNALLETPWRKLC 134
Cdd:COG3332   83 GELVLDFLAGESAPAAYLALLALDAAAYNGFNLLVGDADRL-----FYLSNRGDALVRRLAPGVHGLSNALLDTPWPKVA 157

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 768023312 135 FGKQLFLEAVErsqalPKDVLIASLLDVLNNEEAAarPGHRGPGWGV 181
Cdd:COG3332  158 RLKAALAAALA-----PDDPDPDALFALLADRTPA--PDAELPDTGV 197
 
Name Accession Description Interval E-value
TANGO2 pfam05742
Transport and Golgi organization 2; In eukaryotes this family is predicted to play a role in ...
 55-167 1.24e-41

Transport and Golgi organization 2; In eukaryotes this family is predicted to play a role in protein secretion and Golgi organization. In plants this family includes Swiss:A9X6Y0, which is involved in water permeability in the cuticles of fruit. Swiss:P54797 has been found to be expressed during early embryogenesis in mice. This protein contains a conserved NRDE motif. This gene has been characterized in Drosophila melanogaster and named as transport and Golgi organization 2, hence the name Tango2.


Pssm-ID: 461729  Cd Length: 255  Bit Score: 141.63  E-value: 1.24e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023312   55 GELVTHFLTTDVDSLSYLKKVSMEGHLYNGFNLIAADLSTAKGdvICYYGNRGEPDPIVLTPGTYGLSNALLETPWRKLC 134
Cdd:pfam05742  88 GLLVNDFLTSNPDPEEYLEELAKEADKYNGFNLLVGDLNGSKS--LAYISNRGNPTPDQLSPGIHGLSNSLLDSPWPKVE 165

                          90       100       110
                  ....*....|....*....|....*....|...
gi 768023312  135 FGKQLFLEAVERSQALPKDVLIASLLDVLNNEE 167
Cdd:pfam05742 166 RGKRLFEELVEESVEDSEDQLIEELFDLLSDDT 198
Tango2 COG3332
Uncharacterized stress-responsive protein, TANGO2 (Transport and Golgi organisation 2) family, ...
 55-181 1.16e-25

Uncharacterized stress-responsive protein, TANGO2 (Transport and Golgi organisation 2) family, contains NRDE motif [General function prediction only];


Pssm-ID: 442561  Cd Length: 257  Bit Score: 99.95  E-value: 1.16e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023312  55 GELVTHFLTTDVDSLSYLKKVSMEGHLYNGFNLIAADLSTAkgdviCYYGNRGEPDPIVLTPGTYGLSNALLETPWRKLC 134
Cdd:COG3332   83 GELVLDFLAGESAPAAYLALLALDAAAYNGFNLLVGDADRL-----FYLSNRGDALVRRLAPGVHGLSNALLDTPWPKVA 157

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 768023312 135 FGKQLFLEAVErsqalPKDVLIASLLDVLNNEEAAarPGHRGPGWGV 181
Cdd:COG3332  158 RLKAALAAALA-----PDDPDPDALFALLADRTPA--PDAELPDTGV 197
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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