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Conserved domains on  [gi|768037599|ref|XP_011529218|]
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protocadherin-11 X-linked isoform X10 [Homo sapiens]

Protein Classification

protocadherin( domain architecture ID 13228256)

protocadherin is a transmembrane protein belonging to the cadherin superfamily and may be a calcium-dependent cell-adhesion protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Protocadherin pfam08374
Protocadherin; The structure of protocadherins is similar to that of classic cadherins ...
 804-1005 3.76e-85

Protocadherin; The structure of protocadherins is similar to that of classic cadherins (pfam00028), but particularly on the cytoplasmic domains they also have some unique features. They are expressed in a variety of organizms and are found in high concentrations in the brain where they seem to be localized mainly at cell-cell contact sites. Their expression seems to be developmentally regulated.


:

Pssm-ID: 462451  Cd Length: 217  Bit Score: 273.92  E-value: 3.76e-85
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768037599   804 SVTNATLINELVRKSTEAPVTPNT-EIADVSSPTSDYVKILVAAVAGTITVVVVIFITAVVR-CRQA--PHLKAAQKnkQ 879
Cdd:pfam08374    1 SLANATLVEELVRRSLETPLDRDIaGDPDYSSLGKDYLKILIAILAGAMTVILVIFIVVLVRyCRQKekPGYKAGKK--Q 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768037599   880 NSEWATPNPENRQMIMMKKKKKKKKH---SPKNLLLNFVTIEETKADDVDSDGNRVTLDLPIdleeqtmgkynwvTTPTT 956
Cdd:pfam08374   79 NSDWVTPNPENKQMKGKKKKKKKRPKpakLPKSLLLNLVTIEESKPDDVENEGDSPRIDLPI-------------TLPTT 145

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 768037599   957 FKPDSPDLARHYKSASPQPAFQIQPETPLN-SKHHIIQELPLDNTFV-ACD 1005
Cdd:pfam08374  146 FKPDSPDLARHYKSNSPLPAFQLQPESPSAsKKHQAVQELPLDNTFVgTGD 196
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 603-698 5.11e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 120.11  E-value: 5.11e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768037599  603 EYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRV 680
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDglFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 768037599  681 SRSSSAKVTINVVDVNDN 698
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 282-380 5.21e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 120.11  E-value: 5.21e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768037599  282 EIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSfsnLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDG 361
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYS---IVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                          90       100
                  ....*....|....*....|.
gi 768037599  362 GLMP--ARAMVLVNVTDVNDN 380
Cdd:cd11304    78 GGPPlsSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 501-595 3.17e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 115.10  E-value: 3.17e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768037599  501 TVSIPENNSPGIQLTKVSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPL 579
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYsIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                          90
                  ....*....|....*.
gi 768037599  580 TSNVTVFVSIIDQNDN 595
Cdd:cd11304    83 SSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 172-274 4.95e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 85.83  E-value: 4.95e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768037599  172 VINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIkSQNIFGLDVIETPEGDkmpqLIVQKELDREEKDTYVMKVKVE 251
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIV-SGNEDGLFSIDPSTGE----ITTAKPLDREEQSSYTLTVTAT 75

                          90       100
                  ....*....|....*....|...
gi 768037599  252 DGGFPQRSSTAILQVSVTDTNDN 274
Cdd:cd11304    76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 710-801 1.35e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 84.67  E-value: 1.35e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768037599  710 SYELVLP-STNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQP 788
Cdd:cd11304     1 SYEVSVPeNAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|...
gi 768037599  789 dSLFSVVIVNLFV 801
Cdd:cd11304    81 -PLSSTATVTITV 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 413-493 9.40e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


:

Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 61.60  E-value: 9.40e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768037599    413 TVTDKDADHNGRVTCF---TDHEIPFRLRPvfsNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDEN 489
Cdd:smart00112    1 SATDADSGENGKVTYSilsGNDDGLFSIDP---ETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 768037599    490 DNAP 493
Cdd:smart00112   78 DNAP 81
Cadherin_2 super family cl29227
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 57-131 4.70e-06

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


The actual alignment was detected with superfamily member pfam08266:

Pssm-ID: 462413  Cd Length: 83  Bit Score: 45.60  E-value: 4.70e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 768037599    57 YTIREEMPENVLIGDLLKDLNLSLipnKSLtTAMQFKLVYKtGDVPLIRIEEDTGEIFTTGaRIDREKLCAGIPR 131
Cdd:pfam08266    4 YSVPEETERGSFVGNLAKDLGLEV---GEL-AARGARVVSK-GNKQYFQLNPETGDLLLNE-KLDREELCGSTEP 72
 
Name Accession Description Interval E-value
Protocadherin pfam08374
Protocadherin; The structure of protocadherins is similar to that of classic cadherins ...
 804-1005 3.76e-85

Protocadherin; The structure of protocadherins is similar to that of classic cadherins (pfam00028), but particularly on the cytoplasmic domains they also have some unique features. They are expressed in a variety of organizms and are found in high concentrations in the brain where they seem to be localized mainly at cell-cell contact sites. Their expression seems to be developmentally regulated.


Pssm-ID: 462451  Cd Length: 217  Bit Score: 273.92  E-value: 3.76e-85
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768037599   804 SVTNATLINELVRKSTEAPVTPNT-EIADVSSPTSDYVKILVAAVAGTITVVVVIFITAVVR-CRQA--PHLKAAQKnkQ 879
Cdd:pfam08374    1 SLANATLVEELVRRSLETPLDRDIaGDPDYSSLGKDYLKILIAILAGAMTVILVIFIVVLVRyCRQKekPGYKAGKK--Q 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768037599   880 NSEWATPNPENRQMIMMKKKKKKKKH---SPKNLLLNFVTIEETKADDVDSDGNRVTLDLPIdleeqtmgkynwvTTPTT 956
Cdd:pfam08374   79 NSDWVTPNPENKQMKGKKKKKKKRPKpakLPKSLLLNLVTIEESKPDDVENEGDSPRIDLPI-------------TLPTT 145

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 768037599   957 FKPDSPDLARHYKSASPQPAFQIQPETPLN-SKHHIIQELPLDNTFV-ACD 1005
Cdd:pfam08374  146 FKPDSPDLARHYKSNSPLPAFQLQPESPSAsKKHQAVQELPLDNTFVgTGD 196
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 603-698 5.11e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 120.11  E-value: 5.11e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768037599  603 EYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRV 680
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDglFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 768037599  681 SRSSSAKVTINVVDVNDN 698
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 282-380 5.21e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 120.11  E-value: 5.21e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768037599  282 EIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSfsnLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDG 361
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYS---IVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                          90       100
                  ....*....|....*....|.
gi 768037599  362 GLMP--ARAMVLVNVTDVNDN 380
Cdd:cd11304    78 GGPPlsSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 501-595 3.17e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 115.10  E-value: 3.17e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768037599  501 TVSIPENNSPGIQLTKVSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPL 579
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYsIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                          90
                  ....*....|....*.
gi 768037599  580 TSNVTVFVSIIDQNDN 595
Cdd:cd11304    83 SSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 518-597 3.51e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 94.34  E-value: 3.51e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768037599    518 SAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNS 596
Cdd:smart00112    1 SATDADSGENGKVTYsILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 768037599    597 P 597
Cdd:smart00112   81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 622-700 9.66e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 93.18  E-value: 9.66e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768037599    622 TVTDPDYGDNSAVTLSILDENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNK 699
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDglFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 768037599    700 P 700
Cdd:smart00112   81 P 81
Cadherin pfam00028
Cadherin domain;
283-375 1.71e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 89.67  E-value: 1.71e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768037599   283 IEVSIPENAPVGTSVTQLHATDADIGENAKIHFSfsnLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGG 362
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYS---ILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                           90
                   ....*....|....*
gi 768037599   363 LMP--ARAMVLVNVT 375
Cdd:pfam00028   78 GPPlsSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 301-382 1.14e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 87.02  E-value: 1.14e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768037599    301 HATDADIGENAKIHFSfsnLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMP--ARAMVLVNVTDVN 378
Cdd:smart00112    1 SATDADSGENGKVTYS---ILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPlsSTATVTITVLDVN 77


                    ....
gi 768037599    379 DNVP 382
Cdd:smart00112   78 DNAP 81
Cadherin pfam00028
Cadherin domain;
604-692 1.36e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 87.36  E-value: 1.36e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768037599   604 YNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSIL--DENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVS 681
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILggGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|.
gi 768037599   682 RSSSAKVTINV 692
Cdd:pfam00028   81 LSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
501-590 3.88e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 85.82  E-value: 3.88e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768037599   501 TVSIPENNSPGIQLTKVSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPL 579
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYsILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPL 81

                           90
                   ....*....|.
gi 768037599   580 TSNVTVFVSII 590
Cdd:pfam00028   82 SSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 172-274 4.95e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 85.83  E-value: 4.95e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768037599  172 VINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIkSQNIFGLDVIETPEGDkmpqLIVQKELDREEKDTYVMKVKVE 251
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIV-SGNEDGLFSIDPSTGE----ITTAKPLDREEQSSYTLTVTAT 75

                          90       100
                  ....*....|....*....|...
gi 768037599  252 DGGFPQRSSTAILQVSVTDTNDN 274
Cdd:cd11304    76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 710-801 1.35e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 84.67  E-value: 1.35e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768037599  710 SYELVLP-STNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQP 788
Cdd:cd11304     1 SYEVSVPeNAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|...
gi 768037599  789 dSLFSVVIVNLFV 801
Cdd:cd11304    81 -PLSSTATVTITV 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 192-276 1.07e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 72.77  E-value: 1.07e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768037599    192 AVDPDVGINGVQNYElIKSQNIFGLDVIETPEGdkmpQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDT 271
Cdd:smart00112    2 ATDADSGENGKVTYS-ILSGNDDGLFSIDPETG----EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDV 76


                    ....*
gi 768037599    272 NDNHP 276
Cdd:smart00112   77 NDNAP 81
Cadherin pfam00028
Cadherin domain;
720-801 1.08e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 67.71  E-value: 1.08e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768037599   720 PGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPdSLFSVVIVNL 799
Cdd:pfam00028   11 VGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP-PLSSTATVTI 89


                   ..
gi 768037599   800 FV 801
Cdd:pfam00028   90 TV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 413-493 9.40e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 61.60  E-value: 9.40e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768037599    413 TVTDKDADHNGRVTCF---TDHEIPFRLRPvfsNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDEN 489
Cdd:smart00112    1 SATDADSGENGKVTYSilsGNDDGLFSIDP---ETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 768037599    490 DNAP 493
Cdd:smart00112   78 DNAP 81
Cadherin pfam00028
Cadherin domain;
173-269 2.65e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 60.78  E-value: 2.65e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768037599   173 INISIPENSAINSKYTLPAAVDPDVGINGVQNYeLIKSQNIFGLDVIETPEGDkmpqLIVQKELDREEKDTYVMKVKVED 252
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFY-SILGGGPGGNFRIDPDTGD----ISTTKPLDRESIGEYELTVEATD 75

                           90
                   ....*....|....*..
gi 768037599   253 GGFPQRSSTAILQVSVT 269
Cdd:pfam00028   76 SGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 729-801 4.48e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 59.67  E-value: 4.48e-11
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 768037599    729 AVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPdSLFSVVIVNLFV 801
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP-PLSSTATVTITV 73
Cadherin pfam00028
Cadherin domain;
396-485 2.64e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 55.00  E-value: 2.64e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768037599   396 TVVLSENIPLNTKIALITVTDKDADHNGRVTcftdHEIpfrLRPVFSNQF-------LLETAAYLDYESTKEYAIKLLAA 468
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIF----YSI---LGGGPGGNFridpdtgDISTTKPLDRESIGEYELTVEAT 74

                           90
                   ....*....|....*..
gi 768037599   469 DAGKPPLNQSAMLFIKV 485
Cdd:pfam00028   75 DSGGPPLSSTATVTITV 91
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 57-131 4.70e-06

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 45.60  E-value: 4.70e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 768037599    57 YTIREEMPENVLIGDLLKDLNLSLipnKSLtTAMQFKLVYKtGDVPLIRIEEDTGEIFTTGaRIDREKLCAGIPR 131
Cdd:pfam08266    4 YSVPEETERGSFVGNLAKDLGLEV---GEL-AARGARVVSK-GNKQYFQLNPETGDLLLNE-KLDREELCGSTEP 72
 
Name Accession Description Interval E-value
Protocadherin pfam08374
Protocadherin; The structure of protocadherins is similar to that of classic cadherins ...
 804-1005 3.76e-85

Protocadherin; The structure of protocadherins is similar to that of classic cadherins (pfam00028), but particularly on the cytoplasmic domains they also have some unique features. They are expressed in a variety of organizms and are found in high concentrations in the brain where they seem to be localized mainly at cell-cell contact sites. Their expression seems to be developmentally regulated.


Pssm-ID: 462451  Cd Length: 217  Bit Score: 273.92  E-value: 3.76e-85
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768037599   804 SVTNATLINELVRKSTEAPVTPNT-EIADVSSPTSDYVKILVAAVAGTITVVVVIFITAVVR-CRQA--PHLKAAQKnkQ 879
Cdd:pfam08374    1 SLANATLVEELVRRSLETPLDRDIaGDPDYSSLGKDYLKILIAILAGAMTVILVIFIVVLVRyCRQKekPGYKAGKK--Q 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768037599   880 NSEWATPNPENRQMIMMKKKKKKKKH---SPKNLLLNFVTIEETKADDVDSDGNRVTLDLPIdleeqtmgkynwvTTPTT 956
Cdd:pfam08374   79 NSDWVTPNPENKQMKGKKKKKKKRPKpakLPKSLLLNLVTIEESKPDDVENEGDSPRIDLPI-------------TLPTT 145

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 768037599   957 FKPDSPDLARHYKSASPQPAFQIQPETPLN-SKHHIIQELPLDNTFV-ACD 1005
Cdd:pfam08374  146 FKPDSPDLARHYKSNSPLPAFQLQPESPSAsKKHQAVQELPLDNTFVgTGD 196
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 603-698 5.11e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 120.11  E-value: 5.11e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768037599  603 EYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRV 680
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDglFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 768037599  681 SRSSSAKVTINVVDVNDN 698
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 282-380 5.21e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 120.11  E-value: 5.21e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768037599  282 EIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSfsnLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDG 361
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYS---IVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                          90       100
                  ....*....|....*....|.
gi 768037599  362 GLMP--ARAMVLVNVTDVNDN 380
Cdd:cd11304    78 GGPPlsSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 501-595 3.17e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 115.10  E-value: 3.17e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768037599  501 TVSIPENNSPGIQLTKVSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPL 579
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYsIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                          90
                  ....*....|....*.
gi 768037599  580 TSNVTVFVSIIDQNDN 595
Cdd:cd11304    83 SSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 518-597 3.51e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 94.34  E-value: 3.51e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768037599    518 SAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNS 596
Cdd:smart00112    1 SATDADSGENGKVTYsILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 768037599    597 P 597
Cdd:smart00112   81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 622-700 9.66e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 93.18  E-value: 9.66e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768037599    622 TVTDPDYGDNSAVTLSILDENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNK 699
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDglFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 768037599    700 P 700
Cdd:smart00112   81 P 81
Cadherin pfam00028
Cadherin domain;
283-375 1.71e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 89.67  E-value: 1.71e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768037599   283 IEVSIPENAPVGTSVTQLHATDADIGENAKIHFSfsnLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGG 362
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYS---ILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                           90
                   ....*....|....*
gi 768037599   363 LMP--ARAMVLVNVT 375
Cdd:pfam00028   78 GPPlsSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 301-382 1.14e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 87.02  E-value: 1.14e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768037599    301 HATDADIGENAKIHFSfsnLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMP--ARAMVLVNVTDVN 378
Cdd:smart00112    1 SATDADSGENGKVTYS---ILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPlsSTATVTITVLDVN 77


                    ....
gi 768037599    379 DNVP 382
Cdd:smart00112   78 DNAP 81
Cadherin pfam00028
Cadherin domain;
604-692 1.36e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 87.36  E-value: 1.36e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768037599   604 YNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSIL--DENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVS 681
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILggGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|.
gi 768037599   682 RSSSAKVTINV 692
Cdd:pfam00028   81 LSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
501-590 3.88e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 85.82  E-value: 3.88e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768037599   501 TVSIPENNSPGIQLTKVSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPL 579
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYsILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPL 81

                           90
                   ....*....|.
gi 768037599   580 TSNVTVFVSII 590
Cdd:pfam00028   82 SSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 172-274 4.95e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 85.83  E-value: 4.95e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768037599  172 VINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIkSQNIFGLDVIETPEGDkmpqLIVQKELDREEKDTYVMKVKVE 251
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIV-SGNEDGLFSIDPSTGE----ITTAKPLDREEQSSYTLTVTAT 75

                          90       100
                  ....*....|....*....|...
gi 768037599  252 DGGFPQRSSTAILQVSVTDTNDN 274
Cdd:cd11304    76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 710-801 1.35e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 84.67  E-value: 1.35e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768037599  710 SYELVLP-STNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQP 788
Cdd:cd11304     1 SYEVSVPeNAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|...
gi 768037599  789 dSLFSVVIVNLFV 801
Cdd:cd11304    81 -PLSSTATVTITV 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 192-276 1.07e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 72.77  E-value: 1.07e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768037599    192 AVDPDVGINGVQNYElIKSQNIFGLDVIETPEGdkmpQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDT 271
Cdd:smart00112    2 ATDADSGENGKVTYS-ILSGNDDGLFSIDPETG----EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDV 76


                    ....*
gi 768037599    272 NDNHP 276
Cdd:smart00112   77 NDNAP 81
Cadherin pfam00028
Cadherin domain;
720-801 1.08e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 67.71  E-value: 1.08e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768037599   720 PGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPdSLFSVVIVNL 799
Cdd:pfam00028   11 VGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP-PLSSTATVTI 89


                   ..
gi 768037599   800 FV 801
Cdd:pfam00028   90 TV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 413-493 9.40e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 61.60  E-value: 9.40e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768037599    413 TVTDKDADHNGRVTCF---TDHEIPFRLRPvfsNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDEN 489
Cdd:smart00112    1 SATDADSGENGKVTYSilsGNDDGLFSIDP---ETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 768037599    490 DNAP 493
Cdd:smart00112   78 DNAP 81
Cadherin pfam00028
Cadherin domain;
173-269 2.65e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 60.78  E-value: 2.65e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768037599   173 INISIPENSAINSKYTLPAAVDPDVGINGVQNYeLIKSQNIFGLDVIETPEGDkmpqLIVQKELDREEKDTYVMKVKVED 252
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFY-SILGGGPGGNFRIDPDTGD----ISTTKPLDRESIGEYELTVEATD 75

                           90
                   ....*....|....*..
gi 768037599   253 GGFPQRSSTAILQVSVT 269
Cdd:pfam00028   76 SGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 729-801 4.48e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 59.67  E-value: 4.48e-11
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 768037599    729 AVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPdSLFSVVIVNLFV 801
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP-PLSSTATVTITV 73
Cadherin pfam00028
Cadherin domain;
396-485 2.64e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 55.00  E-value: 2.64e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768037599   396 TVVLSENIPLNTKIALITVTDKDADHNGRVTcftdHEIpfrLRPVFSNQF-------LLETAAYLDYESTKEYAIKLLAA 468
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIF----YSI---LGGGPGGNFridpdtgDISTTKPLDRESIGEYELTVEAT 74

                           90
                   ....*....|....*..
gi 768037599   469 DAGKPPLNQSAMLFIKV 485
Cdd:pfam00028   75 DSGGPPLSSTATVTITV 91
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 57-131 4.70e-06

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 45.60  E-value: 4.70e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 768037599    57 YTIREEMPENVLIGDLLKDLNLSLipnKSLtTAMQFKLVYKtGDVPLIRIEEDTGEIFTTGaRIDREKLCAGIPR 131
Cdd:pfam08266    4 YSVPEETERGSFVGNLAKDLGLEV---GEL-AARGARVVSK-GNKQYFQLNPETGDLLLNE-KLDREELCGSTEP 72
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 283-380 4.63e-05

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 43.49  E-value: 4.63e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768037599  283 IEVSIPENAPVGTSVTQLhatDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLA-SDG 361
Cdd:cd00031     2 PDGSAVEGRSRGSFRVSI---PTDLIASSGEIIKISAAGKEALPSWLHWEPHSGILEGLEKLDREDKGVHYISVSAaSLG 78

                          90       100
                  ....*....|....*....|
gi 768037599  362 GLMPARAMVLV-NVTDVNDN 380
Cdd:cd00031    79 ANVPQTSSVFSiEVYDENDN 98
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 501-595 7.84e-05

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 42.72  E-value: 7.84e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768037599  501 TVSIPENNSPGIQLTKV-SAMDADSGPNAKINYLlGPDAPPE-FSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPP 578
Cdd:cd00031     3 DGSAVEGRSRGSFRVSIpTDLIASSGEIIKISAA-GKEALPSwLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGANV 81

                          90
                  ....*....|....*..
gi 768037599  579 LTSNVTVFVSIIDQNDN 595
Cdd:cd00031    82 PQTSSVFSIEVYDENDN 98
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 283-348 3.10e-04

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 40.59  E-value: 3.10e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 768037599   283 IEVSIPENAPVGTSVTQLhATD--ADIGE----NAKIhfsfsnlVSNIARRLFHLNATTGLITIKEPLDREE 348
Cdd:pfam08266    2 IRYSVPEETERGSFVGNL-AKDlgLEVGElaarGARV-------VSKGNKQYFQLNPETGDLLLNEKLDREE 65
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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