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Conserved domains on  [gi|768040925|ref|XP_011529763|]
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histone demethylase UTY isoform X25 [Homo sapiens]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11419012)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

Gene Ontology:  GO:0005515
PubMed:  10517866|30708253

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
103-375 3.66e-18

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 223533 [Multi-domain]  Cd Length: 291  Bit Score: 86.44  E-value: 3.66e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040925  103 LEDYSKALSAYqrYYSLQADYWKNAAFLYGLGLVYFYYNAFHWAIKAFQDVLYVDPSFCRAKEIHlRLGLMFKVNTDYKS 182
Cdd:COG0457     1 LKDLLLALAIL--LEALAKLLAEALALLEAGLALLELLGELAEALELLEEALELLPNSDLAGLLL-LLALALLKLGRLEE 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040925  183 SLKHFQLALIdcNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTENLPAQVKAtvLQQLGWMHHNMDLvgdkatk 262
Cdd:COG0457    78 ALELLEKALE--LELLPNLAEALLNLGLLLEALGKYEEALELLEKALALDPDPDLAEA--LLALGALYELGDY------- 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040925  263 eSYAIQYLQKSLEADP---NSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKS-EASADTWCSIGVLYQQQNQPMDALQAY 338
Cdd:COG0457   147 -EEALELYEKALELDPelnELAEALLALGALLEALGRYEEALELLEKALKLNpDDDAEALLNLGLLYLKLGKYEEALEYY 225
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 768040925  339 ICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYLNA 375
Cdd:COG0457   226 EKALELDPDNAEALYNLALLLLELGRYEEALEALEKA 262
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
103-375 3.66e-18

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 223533 [Multi-domain]  Cd Length: 291  Bit Score: 86.44  E-value: 3.66e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040925  103 LEDYSKALSAYqrYYSLQADYWKNAAFLYGLGLVYFYYNAFHWAIKAFQDVLYVDPSFCRAKEIHlRLGLMFKVNTDYKS 182
Cdd:COG0457     1 LKDLLLALAIL--LEALAKLLAEALALLEAGLALLELLGELAEALELLEEALELLPNSDLAGLLL-LLALALLKLGRLEE 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040925  183 SLKHFQLALIdcNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTENLPAQVKAtvLQQLGWMHHNMDLvgdkatk 262
Cdd:COG0457    78 ALELLEKALE--LELLPNLAEALLNLGLLLEALGKYEEALELLEKALALDPDPDLAEA--LLALGALYELGDY------- 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040925  263 eSYAIQYLQKSLEADP---NSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKS-EASADTWCSIGVLYQQQNQPMDALQAY 338
Cdd:COG0457   147 -EEALELYEKALELDPelnELAEALLALGALLEALGRYEEALELLEKALKLNpDDDAEALLNLGLLYLKLGKYEEALEYY 225
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 768040925  339 ICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYLNA 375
Cdd:COG0457   226 EKALELDPDNAEALYNLALLLLELGRYEEALEALEKA 262
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
84-419 1.04e-07

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 56.25  E-value: 1.04e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040925    84 AEGKVESD--FFCQLGHFNLLLEDYSKALSAYQRYYSLQAdywKNAAFLYGLGLVYFYYNAFHWAIKAFQDVLYVDPSFC 161
Cdd:TIGR02917  355 ALGLDPDDpaALSLLGEAYLALGDFEKAAEYLAKATELDP---ENAAARTQLGISKLSQGDPSEAIADLETAAQLDPELG 431
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040925   162 RAKEI----HLRLGLMFKVNTDYKSSLKHfqlalidcnpcTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTEnlPAQ 237
Cdd:TIGR02917  432 RADLLlilsYLRSGQFDKALAAAKKLEKK-----------QPDNASLHNLLGAIYLGKGDLAKAREAFEKALSIE--PDF 498
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040925   238 VKATVLQQlgwmhhNMDLVGDKATKesyAIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADT 317
Cdd:TIGR02917  499 FPAAANLA------RIDIQEGNPDD---AIQRFEKVLTIDPKNLRAILALAGLYLRTGNEEEAVAWLEKAAELNPQEIEP 569
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040925   318 WCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYLNAArsKRCSNTSTLAARIKFLQAq 397
Cdd:TIGR02917  570 ALALAQYYLGKGQLKKALAILNEAADAAPDSPEAWLMLGRAQLAAGDLNKAVSSFKKLL--ALQPDSALALLLLADAYA- 646
                          330       340
                   ....*....|....*....|..
gi 768040925   398 lcnlpqsSLQNKTKLLPSIEEA 419
Cdd:TIGR02917  647 -------VMKNYAKAITSLKRA 661
TPR_1 pfam00515
Tetratricopeptide repeat;
127-160 4.76e-03

Tetratricopeptide repeat;


Pssm-ID: 425728 [Multi-domain]  Cd Length: 34  Bit Score: 35.86  E-value: 4.76e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 768040925   127 AAFLYGLGLVYFYYNAFHWAIKAFQDVLYVDPSF 160
Cdd:pfam00515    1 AKALYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
103-375 3.66e-18

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 223533 [Multi-domain]  Cd Length: 291  Bit Score: 86.44  E-value: 3.66e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040925  103 LEDYSKALSAYqrYYSLQADYWKNAAFLYGLGLVYFYYNAFHWAIKAFQDVLYVDPSFCRAKEIHlRLGLMFKVNTDYKS 182
Cdd:COG0457     1 LKDLLLALAIL--LEALAKLLAEALALLEAGLALLELLGELAEALELLEEALELLPNSDLAGLLL-LLALALLKLGRLEE 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040925  183 SLKHFQLALIdcNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTENLPAQVKAtvLQQLGWMHHNMDLvgdkatk 262
Cdd:COG0457    78 ALELLEKALE--LELLPNLAEALLNLGLLLEALGKYEEALELLEKALALDPDPDLAEA--LLALGALYELGDY------- 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040925  263 eSYAIQYLQKSLEADP---NSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKS-EASADTWCSIGVLYQQQNQPMDALQAY 338
Cdd:COG0457   147 -EEALELYEKALELDPelnELAEALLALGALLEALGRYEEALELLEKALKLNpDDDAEALLNLGLLYLKLGKYEEALEYY 225
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 768040925  339 ICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYLNA 375
Cdd:COG0457   226 EKALELDPDNAEALYNLALLLLELGRYEEALEALEKA 262
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
44-312 6.53e-18

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 223533 [Multi-domain]  Cd Length: 291  Bit Score: 85.67  E-value: 6.53e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040925   44 EALGGMDSRLFGFVRLHEDGARTKTLLGKAVRCYESLILKAEGKVESDFFCQLGHFNLLLEDYSKALSAYQRYYSLQADY 123
Cdd:COG0457    13 EALAKLLAEALALLEAGLALLELLGELAEALELLEEALELLPNSDLAGLLLLLALALLKLGRLEEALELLEKALELELLP 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040925  124 wKNAAFLYGLGLVYFYYNAFHWAIKAFQDVLYVDPSFCRAkEIHLRLGLMFKVNtDYKSSLKHFQLALiDCNPCTLSNAE 203
Cdd:COG0457    93 -NLAEALLNLGLLLEALGKYEEALELLEKALALDPDPDLA-EALLALGALYELG-DYEEALELYEKAL-ELDPELNELAE 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040925  204 IQFHIAHLYETQRKYHSAKEAYEQLLQtenLPAQVKATVLQQLGWMHHNMDLVGDkatkesyAIQYLQKSLEADPNSGQS 283
Cdd:COG0457   169 ALLALGALLEALGRYEEALELLEKALK---LNPDDDAEALLNLGLLYLKLGKYEE-------ALEYYEKALELDPDNAEA 238
                         250       260
                  ....*....|....*....|....*....
gi 768040925  284 WYFLGRCYSSIGKVQDAFISYRQSIDKSE 312
Cdd:COG0457   239 LYNLALLLLELGRYEEALEALEKALELDP 267
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
162-422 4.13e-14

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 223533 [Multi-domain]  Cd Length: 291  Bit Score: 74.50  E-value: 4.13e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040925  162 RAKEIHLRLGLMFKVNTDYKSSLKHFQLALIDCNPctLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTENLPAQVKAt 241
Cdd:COG0457    21 EALALLEAGLALLELLGELAEALELLEEALELLPN--SDLAGLLLLLALALLKLGRLEEALELLEKALELELLPNLAEA- 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040925  242 vlqqlgwmHHNMDLVGDKATKESYAIQYLQKSLEADPNSGQSWYFLGR-CYSSIGKVQDAFISYRQSIDKSEAS---ADT 317
Cdd:COG0457    98 --------LLNLGLLLEALGKYEEALELLEKALALDPDPDLAEALLALgALYELGDYEEALELYEKALELDPELnelAEA 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040925  318 WCSIGVLYQQQNQPMDALQAYICAVQLDHGHAA-AWMDLGTLYESCNQPQDAIKCYLNAARSKRCSNTSTLAARIKFLQA 396
Cdd:COG0457   170 LLALGALLEALGRYEEALELLEKALKLNPDDDAeALLNLGLLYLKLGKYEEALEYYEKALELDPDNAEALYNLALLLLEL 249
                         250       260
                  ....*....|....*....|....*..
gi 768040925  397 QLCNLPQSSLQNKTKLLPS-IEEAWSL 422
Cdd:COG0457   250 GRYEEALEALEKALELDPDlYNLGLAL 276
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
266-369 9.17e-10

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 226687 [Multi-domain]  Cd Length: 287  Bit Score: 61.24  E-value: 9.17e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040925  266 AIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIG-VLYQQQNQPMDAL--QAYICAV 342
Cdd:COG4235   141 LIARLETHLQQNPGDAEGWDLLGRAYMALGRASDALLAYRNALRLAGDNPEILLGLAeALYYQAGQQMTAKarALLRQAL 220
                          90       100
                  ....*....|....*....|....*..
gi 768040925  343 QLDHGHAAAWMDLGTLYESCNQPQDAI 369
Cdd:COG4235   221 ALDPANIRALSLLAFAAFEQGDYAEAA 247
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
84-419 1.04e-07

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 56.25  E-value: 1.04e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040925    84 AEGKVESD--FFCQLGHFNLLLEDYSKALSAYQRYYSLQAdywKNAAFLYGLGLVYFYYNAFHWAIKAFQDVLYVDPSFC 161
Cdd:TIGR02917  355 ALGLDPDDpaALSLLGEAYLALGDFEKAAEYLAKATELDP---ENAAARTQLGISKLSQGDPSEAIADLETAAQLDPELG 431
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040925   162 RAKEI----HLRLGLMFKVNTDYKSSLKHfqlalidcnpcTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTEnlPAQ 237
Cdd:TIGR02917  432 RADLLlilsYLRSGQFDKALAAAKKLEKK-----------QPDNASLHNLLGAIYLGKGDLAKAREAFEKALSIE--PDF 498
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040925   238 VKATVLQQlgwmhhNMDLVGDKATKesyAIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADT 317
Cdd:TIGR02917  499 FPAAANLA------RIDIQEGNPDD---AIQRFEKVLTIDPKNLRAILALAGLYLRTGNEEEAVAWLEKAAELNPQEIEP 569
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040925   318 WCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYLNAArsKRCSNTSTLAARIKFLQAq 397
Cdd:TIGR02917  570 ALALAQYYLGKGQLKKALAILNEAADAAPDSPEAWLMLGRAQLAAGDLNKAVSSFKKLL--ALQPDSALALLLLADAYA- 646
                          330       340
                   ....*....|....*....|..
gi 768040925   398 lcnlpqsSLQNKTKLLPSIEEA 419
Cdd:TIGR02917  647 -------VMKNYAKAITSLKRA 661
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
162-372 3.08e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 48.16  E-value: 3.08e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040925   162 RAKEIHLRLGLMFKVNTDYKSSLKHFQlALIDCNPctlSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTE--NLPAQVk 239
Cdd:TIGR02917  599 DSPEAWLMLGRAQLAAGDLNKAVSSFK-KLLALQP---DSALALLLLADAYAVMKNYAKAITSLKRALELKpdNTEAQI- 673
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040925   240 atVLQQLgwmhhnmdLVGDKATKESYAI-QYLQKsleADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIdKSEASADTW 318
Cdd:TIGR02917  674 --GLAQL--------LLAAKRTESAKKIaKSLQK---QHPKAALGFELEGDLYLRQKDYPAAIQAYRKAL-KRAPSSQNA 739
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....
gi 768040925   319 CSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCY 372
Cdd:TIGR02917  740 IKLHRALLASGNTAEAVKTLEAWLKTHPNDAVLRTALAELYLAQKDYDKAIKHY 793
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
82-317 9.29e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 46.62  E-value: 9.29e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040925    82 LKAEGKVESDFF-CQLGHFNLLLEDySKALSAYQRYYSLQADYWKNAAFLYGLGLVYFYYNAFHWAIKAFQDVLYVDPSF 160
Cdd:TIGR02917  658 LKRALELKPDNTeAQIGLAQLLLAA-KRTESAKKIAKSLQKQHPKAALGFELEGDLYLRQKDYPAAIQAYRKALKRAPSS 736
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040925   161 CRAKEIHLRLGLmfkvNTDYKSSLKHFQLALIDcNPctlSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTenlpAQVKA 240
Cdd:TIGR02917  737 QNAIKLHRALLA----SGNTAEAVKTLEAWLKT-HP---NDAVLRTALAELYLAQKDYDKAIKHYQTVVKK----APDNA 804
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 768040925   241 TVLQQLGWMHHNMdlvgdkatKESYAIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADT 317
Cdd:TIGR02917  805 VVLNNLAWLYLEL--------KDPRALEYAERALKLAPNIPAILDTLGWLLVEKGEADRALPLLRKAVNIAPEAAAI 873
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
105-372 9.53e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 46.62  E-value: 9.53e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040925   105 DYSKALSAYQRYYSLQADYWkNAAFLygLGLVYFYYNAFHWAIKAFQDVLYVDPSFCRAKE----IHLRLGLMfkvnTDY 180
Cdd:TIGR02917  276 NYEDARETLQDALKSAPEYL-PALLL--AGASEYQLGNLEQAYQYLNQILKYAPNSHQARRllasIQLRLGRV----DEA 348
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040925   181 KSSLKHFqLALIDCNPCTLSNAEIqfhiAHLyeTQRKYHSAKEAYEQLlqTENLPAQVKATVLQQLGWMHHNmdlvgdka 260
Cdd:TIGR02917  349 IATLSPA-LGLDPDDPAALSLLGE----AYL--ALGDFEKAAEYLAKA--TELDPENAAARTQLGISKLSQG-------- 411
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040925   261 tKESYAIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYIC 340
Cdd:TIGR02917  412 -DPSEAIADLETAAQLDPELGRADLLLILSYLRSGQFDKALAAAKKLEKKQPDNASLHNLLGAIYLGKGDLAKAREAFEK 490
                          250       260       270
                   ....*....|....*....|....*....|..
gi 768040925   341 AVQLDHGHAAAWMDLGTLYESCNQPQDAIKCY 372
Cdd:TIGR02917  491 ALSIEPDFFPAAANLARIDIQEGNPDDAIQRF 522
YfgC COG4783
Putative Zn-dependent protease, contains TPR repeats [General function prediction only];
179-338 1.39e-03

Putative Zn-dependent protease, contains TPR repeats [General function prediction only];


Pssm-ID: 227122 [Multi-domain]  Cd Length: 484  Bit Score: 42.77  E-value: 1.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040925  179 DYKSSLKHFQlALIDCNPctlSNAEIQFHIAHLYETQRKYHSAKEAYEQLL-QTENLPAqvkatvlqqLGWMHHNMDLVG 257
Cdd:COG4783   321 QYDEALKLLQ-PLIAAQP---DNPYYLELAGDILLEANKAKEAIERLKKALaLDPNSPL---------LQLNLAQALLKG 387
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040925  258 DKATKesyAIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAfisyrqsidkSEASADTWCSIGVLYQQQNQPMDALQA 337
Cdd:COG4783   388 GKPQE---AIRILNRYLFNDPEDPNGWDLLAQAYAELGNRAEA----------LLARAEGYALAGRLEQAIIFLMRASQQ 454

                  .
gi 768040925  338 Y 338
Cdd:COG4783   455 V 455
type_IV_pilW TIGR02521
type IV pilus biogenesis/stability protein PilW; Members of this family are designated PilF ...
133-317 3.86e-03

type IV pilus biogenesis/stability protein PilW; Members of this family are designated PilF and PilW. This outer membrane protein is required both for pilus stability and for pilus function such as adherence to human cells. Members of this family contain copies of the TPR (tetratricopeptide repeat) domain.


Pssm-ID: 131573 [Multi-domain]  Cd Length: 234  Bit Score: 40.40  E-value: 3.86e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040925   133 LGLVYFYYNAFHWAIKAFQDVLYVDPSFCRAkeiHLRLGLMFKVNTDYKSSLKHFQLALidcnpcTLSNAEIQFHI---A 209
Cdd:TIGR02521   37 LALGYLEQGDLEVAKENLDKALEHDPDDYLA---YLALALYYQQLGELEKAEDSFRRAL------TLNPNNGDVLNnygT 107
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040925   210 HLYEtQRKYHSAKEAYEQLLQTENLPAQVKAtvlqqlgwmHHNMDLVGDKATKESYAIQYLQKSLEADPNSGQSWYFLGR 289
Cdd:TIGR02521  108 FLCQ-QGKYEQAMQQFEQAIEDPLYPQPARS---------LENAGLCALKAGDFDKAEKYLTRALQIDPQRPESLLELAE 177
                          170       180
                   ....*....|....*....|....*...
gi 768040925   290 CYSSIGKVQDAFISYRQSIDKSEASADT 317
Cdd:TIGR02521  178 LYYLRGQYKDARAYLERYQQTYNQTAES 205
TPR_1 pfam00515
Tetratricopeptide repeat;
127-160 4.76e-03

Tetratricopeptide repeat;


Pssm-ID: 425728 [Multi-domain]  Cd Length: 34  Bit Score: 35.86  E-value: 4.76e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 768040925   127 AAFLYGLGLVYFYYNAFHWAIKAFQDVLYVDPSF 160
Cdd:pfam00515    1 AKALYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
PilF COG3063
Tfp pilus assembly protein PilF [Cell motility, Extracellular structures];
266-356 5.67e-03

Tfp pilus assembly protein PilF [Cell motility, Extracellular structures];


Pssm-ID: 225605 [Multi-domain]  Cd Length: 250  Bit Score: 39.72  E-value: 5.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768040925  266 AIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLD 345
Cdd:COG3063    54 AKKNLEKALEHDPSYYLAHLVRAHYYQKLGENDLADESYRKALSLAPNNGDVLNNYGAFLCAQGRPEEAMQQFERALADP 133
                          90
                  ....*....|...
gi 768040925  346 H--GHAAAWMDLG 356
Cdd:COG3063   134 AygEPSDTLENLG 146
TPR_17 pfam13431
Tetratricopeptide repeat;
269-300 7.67e-03

Tetratricopeptide repeat;


Pssm-ID: 433201 [Multi-domain]  Cd Length: 34  Bit Score: 35.21  E-value: 7.67e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 768040925   269 YLQKSLEADPNSGQSWYFLGRCYSSIGKVQDA 300
Cdd:pfam13431    1 LYLKALELDPNNADAYYNLAVLLLELGQSETA 32
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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