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Conserved domains on  [gi|767938664|ref|XP_011532967|]
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calnexin isoform X2 [Homo sapiens]

Protein Classification

calreticulin family protein (domain architecture ID 10446997)

calreticulin family protein similar to calnexin which is a calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Calreticulin pfam00262
Calreticulin family;
71-440 0e+00

Calreticulin family;


:

Pssm-ID: 395201  Cd Length: 369  Bit Score: 684.29  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767938664   71 FADSFDRGTL-SGWILSKAKKDDTDDEIAKYDGKWEVEEMKESK-LPGDKGLVLMSRAKHHAISAKLNKPFLFDTKPLIV 148
Cdd:pfam00262   1 FFEQFDDYDWeSRWIPSKAKKDDEDDEIAKYDGKWSVEEPTVYPgFEGDKGLVLKSKAKHHAISAKLDKPIDFKNKTLVV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767938664  149 QYEVNFQNGIECGGAYVKLLSKTPELNLDQFHDKTPYTIMFGPDKCGEDYKLHFIFRHKNPKTGIYEEKHAKRPDAdlkt 228
Cdd:pfam00262  81 QYEVKLQNGLECGGAYIKLLSETNDLDLEEFSDKTPYTIMFGPDKCGSTNKVHFIFRHKNPKTGEYEEKHLKKPPK---- 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767938664  229 YFTDKKTHLYTLILNPDNSFEILVDQSVVNSGNLLNDMTPPVNPSREIEDPEDRKPEDWDERPKIPDPEAVKPDDWDEDA 308
Cdd:pfam00262 157 IRTDKLTHLYTLILRPDNTFEIRIDGEVVKSGNLLEDFKPPVNPPKEIDDPNDKKPEDWDDREKIPDPNAVKPDDWDEDA 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767938664  309 PAKIPDEEATKPEGWLDDEPEYVPDPDAEKPEDWDEDMDGEWEAPQIANPRCESAPGCGVWQRPVIDNPNYKGKWKPPMI 388
Cdd:pfam00262 237 PEFIPDPDATKPEGWLEDEPEYIPDPEATKPEDWDEEEDGEWEAPLIPNPKCEEAPGCGPWKPPMIKNPKYKGKWKPPMI 316
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 767938664  389 DNPSYQGIWKPRKIPNPDFFEDLEPFR-MTPFSAIGLELWSMTSDIFFDNFII 440
Cdd:pfam00262 317 DNPNYKGEWKPRKIPNPDYFEDKHPFSnLEPIGAIGFELWSMSKDILFDNIYI 369
 
Name Accession Description Interval E-value
Calreticulin pfam00262
Calreticulin family;
71-440 0e+00

Calreticulin family;


Pssm-ID: 395201  Cd Length: 369  Bit Score: 684.29  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767938664   71 FADSFDRGTL-SGWILSKAKKDDTDDEIAKYDGKWEVEEMKESK-LPGDKGLVLMSRAKHHAISAKLNKPFLFDTKPLIV 148
Cdd:pfam00262   1 FFEQFDDYDWeSRWIPSKAKKDDEDDEIAKYDGKWSVEEPTVYPgFEGDKGLVLKSKAKHHAISAKLDKPIDFKNKTLVV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767938664  149 QYEVNFQNGIECGGAYVKLLSKTPELNLDQFHDKTPYTIMFGPDKCGEDYKLHFIFRHKNPKTGIYEEKHAKRPDAdlkt 228
Cdd:pfam00262  81 QYEVKLQNGLECGGAYIKLLSETNDLDLEEFSDKTPYTIMFGPDKCGSTNKVHFIFRHKNPKTGEYEEKHLKKPPK---- 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767938664  229 YFTDKKTHLYTLILNPDNSFEILVDQSVVNSGNLLNDMTPPVNPSREIEDPEDRKPEDWDERPKIPDPEAVKPDDWDEDA 308
Cdd:pfam00262 157 IRTDKLTHLYTLILRPDNTFEIRIDGEVVKSGNLLEDFKPPVNPPKEIDDPNDKKPEDWDDREKIPDPNAVKPDDWDEDA 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767938664  309 PAKIPDEEATKPEGWLDDEPEYVPDPDAEKPEDWDEDMDGEWEAPQIANPRCESAPGCGVWQRPVIDNPNYKGKWKPPMI 388
Cdd:pfam00262 237 PEFIPDPDATKPEGWLEDEPEYIPDPEATKPEDWDEEEDGEWEAPLIPNPKCEEAPGCGPWKPPMIKNPKYKGKWKPPMI 316
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 767938664  389 DNPSYQGIWKPRKIPNPDFFEDLEPFR-MTPFSAIGLELWSMTSDIFFDNFII 440
Cdd:pfam00262 317 DNPNYKGEWKPRKIPNPDYFEDKHPFSnLEPIGAIGFELWSMSKDILFDNIYI 369
 
Name Accession Description Interval E-value
Calreticulin pfam00262
Calreticulin family;
71-440 0e+00

Calreticulin family;


Pssm-ID: 395201  Cd Length: 369  Bit Score: 684.29  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767938664   71 FADSFDRGTL-SGWILSKAKKDDTDDEIAKYDGKWEVEEMKESK-LPGDKGLVLMSRAKHHAISAKLNKPFLFDTKPLIV 148
Cdd:pfam00262   1 FFEQFDDYDWeSRWIPSKAKKDDEDDEIAKYDGKWSVEEPTVYPgFEGDKGLVLKSKAKHHAISAKLDKPIDFKNKTLVV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767938664  149 QYEVNFQNGIECGGAYVKLLSKTPELNLDQFHDKTPYTIMFGPDKCGEDYKLHFIFRHKNPKTGIYEEKHAKRPDAdlkt 228
Cdd:pfam00262  81 QYEVKLQNGLECGGAYIKLLSETNDLDLEEFSDKTPYTIMFGPDKCGSTNKVHFIFRHKNPKTGEYEEKHLKKPPK---- 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767938664  229 YFTDKKTHLYTLILNPDNSFEILVDQSVVNSGNLLNDMTPPVNPSREIEDPEDRKPEDWDERPKIPDPEAVKPDDWDEDA 308
Cdd:pfam00262 157 IRTDKLTHLYTLILRPDNTFEIRIDGEVVKSGNLLEDFKPPVNPPKEIDDPNDKKPEDWDDREKIPDPNAVKPDDWDEDA 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767938664  309 PAKIPDEEATKPEGWLDDEPEYVPDPDAEKPEDWDEDMDGEWEAPQIANPRCESAPGCGVWQRPVIDNPNYKGKWKPPMI 388
Cdd:pfam00262 237 PEFIPDPDATKPEGWLEDEPEYIPDPEATKPEDWDEEEDGEWEAPLIPNPKCEEAPGCGPWKPPMIKNPKYKGKWKPPMI 316
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 767938664  389 DNPSYQGIWKPRKIPNPDFFEDLEPFR-MTPFSAIGLELWSMTSDIFFDNFII 440
Cdd:pfam00262 317 DNPNYKGEWKPRKIPNPDYFEDKHPFSnLEPIGAIGFELWSMSKDILFDNIYI 369
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.19
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
  • Marchler-Bauer A et al. (2015), "CDD: NCBI's conserved domain database.", Nucleic Acids Res.43(D)222-6.
  • Marchler-Bauer A et al. (2011), "CDD: a Conserved Domain Database for the functional annotation of proteins.", Nucleic Acids Res.39(D)225-9.
  • Marchler-Bauer A, Bryant SH (2004), "CD-Search: protein domain annotations on the fly.", Nucleic Acids Res.32(W)327-331.
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