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Conserved domains on  [gi|767980903|ref|XP_011535213|]
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vertnin isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
OTU_VRTN cd22791
OTU (ovarian tumor) domain of vertnin and similar proteins; Vertnin (VRTN) is an OTU ...
74-241 6.82e-54

OTU (ovarian tumor) domain of vertnin and similar proteins; Vertnin (VRTN) is an OTU domain-containing protein that is required for the development of thoracic vertebrae in mammals. OTU domains typically function as deubiquitinases (DUBs)/ubiquitin thiolesterases (EC 3.4.19.12) that catalyze the thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin, a small regulatory protein that can be conjugated to a large range of target proteins. Protein ubiquitination is a post-translational modification of mostly Lys residues that regulates many cellular processes, including protein degradation, intracellular trafficking, cell signaling, autophagy, transcription, translation, and the DNA damage response. These DUBs may play important regulatory roles at the level of protein turnover by preventing degradation. Vertnin and some subfamily members do not possess the conserved catalytic residues and may not have DUB activity. VRTN gene is associated with variations in vertebral number.


:

Pssm-ID: 438612  Cd Length: 137  Bit Score: 181.26  E-value: 6.82e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980903  74 MLPLVCKGEGSLLFEAASMLLWGDAGLSLELRARTVVEMLLHRHYYlqgmidskvmlqavryslcseespemtslppatl 153
Cdd:cd22791    1 LEPLRVTGDGNCLFRAASLLLFGDESLHLELRLRTVLELVLNSEFY---------------------------------- 46
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980903 154 EAIFDADVKASCFPSSFSNVWHLYALASVLQRNIYSIYPMRNL-KIRPYFNRVIRPRRCDHVPSTLHIMWAGQ--PLTSH 230
Cdd:cd22791   47 EAIYEAEIKATCKPGSYSGIWHIYALSSVLQRPIFSVYPEVGNqKIRPLLNRTIRPRKTSKSIETIHIMWTSTslKNNSS 126
                        170
                 ....*....|.
gi 767980903 231 FFRHQYFAPVV 241
Cdd:cd22791  127 NWKPNHFVPLL 137
transpos_IS481 super family cl41329
IS481 family transposase; null
271-305 9.40e-03

IS481 family transposase; null


The actual alignment was detected with superfamily member NF033577:

Pssm-ID: 411202 [Multi-domain]  Cd Length: 283  Bit Score: 38.73  E-value: 9.40e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 767980903 271 LELLNR--EPGLSYSHLCERYSVTKSTFYRWRRQSQE 305
Cdd:NF033577   3 LELVRLvlEDGWSVREAARRFGISRKTVYKWLKRYRA 39
 
Name Accession Description Interval E-value
OTU_VRTN cd22791
OTU (ovarian tumor) domain of vertnin and similar proteins; Vertnin (VRTN) is an OTU ...
74-241 6.82e-54

OTU (ovarian tumor) domain of vertnin and similar proteins; Vertnin (VRTN) is an OTU domain-containing protein that is required for the development of thoracic vertebrae in mammals. OTU domains typically function as deubiquitinases (DUBs)/ubiquitin thiolesterases (EC 3.4.19.12) that catalyze the thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin, a small regulatory protein that can be conjugated to a large range of target proteins. Protein ubiquitination is a post-translational modification of mostly Lys residues that regulates many cellular processes, including protein degradation, intracellular trafficking, cell signaling, autophagy, transcription, translation, and the DNA damage response. These DUBs may play important regulatory roles at the level of protein turnover by preventing degradation. Vertnin and some subfamily members do not possess the conserved catalytic residues and may not have DUB activity. VRTN gene is associated with variations in vertebral number.


Pssm-ID: 438612  Cd Length: 137  Bit Score: 181.26  E-value: 6.82e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980903  74 MLPLVCKGEGSLLFEAASMLLWGDAGLSLELRARTVVEMLLHRHYYlqgmidskvmlqavryslcseespemtslppatl 153
Cdd:cd22791    1 LEPLRVTGDGNCLFRAASLLLFGDESLHLELRLRTVLELVLNSEFY---------------------------------- 46
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980903 154 EAIFDADVKASCFPSSFSNVWHLYALASVLQRNIYSIYPMRNL-KIRPYFNRVIRPRRCDHVPSTLHIMWAGQ--PLTSH 230
Cdd:cd22791   47 EAIYEAEIKATCKPGSYSGIWHIYALSSVLQRPIFSVYPEVGNqKIRPLLNRTIRPRKTSKSIETIHIMWTSTslKNNSS 126
                        170
                 ....*....|.
gi 767980903 231 FFRHQYFAPVV 241
Cdd:cd22791  127 NWKPNHFVPLL 137
transpos_IS481 NF033577
IS481 family transposase; null
271-305 9.40e-03

IS481 family transposase; null


Pssm-ID: 411202 [Multi-domain]  Cd Length: 283  Bit Score: 38.73  E-value: 9.40e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 767980903 271 LELLNR--EPGLSYSHLCERYSVTKSTFYRWRRQSQE 305
Cdd:NF033577   3 LELVRLvlEDGWSVREAARRFGISRKTVYKWLKRYRA 39
 
Name Accession Description Interval E-value
OTU_VRTN cd22791
OTU (ovarian tumor) domain of vertnin and similar proteins; Vertnin (VRTN) is an OTU ...
74-241 6.82e-54

OTU (ovarian tumor) domain of vertnin and similar proteins; Vertnin (VRTN) is an OTU domain-containing protein that is required for the development of thoracic vertebrae in mammals. OTU domains typically function as deubiquitinases (DUBs)/ubiquitin thiolesterases (EC 3.4.19.12) that catalyze the thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin, a small regulatory protein that can be conjugated to a large range of target proteins. Protein ubiquitination is a post-translational modification of mostly Lys residues that regulates many cellular processes, including protein degradation, intracellular trafficking, cell signaling, autophagy, transcription, translation, and the DNA damage response. These DUBs may play important regulatory roles at the level of protein turnover by preventing degradation. Vertnin and some subfamily members do not possess the conserved catalytic residues and may not have DUB activity. VRTN gene is associated with variations in vertebral number.


Pssm-ID: 438612  Cd Length: 137  Bit Score: 181.26  E-value: 6.82e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980903  74 MLPLVCKGEGSLLFEAASMLLWGDAGLSLELRARTVVEMLLHRHYYlqgmidskvmlqavryslcseespemtslppatl 153
Cdd:cd22791    1 LEPLRVTGDGNCLFRAASLLLFGDESLHLELRLRTVLELVLNSEFY---------------------------------- 46
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980903 154 EAIFDADVKASCFPSSFSNVWHLYALASVLQRNIYSIYPMRNL-KIRPYFNRVIRPRRCDHVPSTLHIMWAGQ--PLTSH 230
Cdd:cd22791   47 EAIYEAEIKATCKPGSYSGIWHIYALSSVLQRPIFSVYPEVGNqKIRPLLNRTIRPRKTSKSIETIHIMWTSTslKNNSS 126
                        170
                 ....*....|.
gi 767980903 231 FFRHQYFAPVV 241
Cdd:cd22791  127 NWKPNHFVPLL 137
OTU cd22744
OTU (ovarian tumor) domain family; The OTU family of cysteine proteases use a conserved ...
79-231 1.71e-09

OTU (ovarian tumor) domain family; The OTU family of cysteine proteases use a conserved cysteine and histidine, and in most cases an aspartate, as the catalytic triad. OTU domains typically function as deubiquitinases (DUBs)/ubiquitin thiolesterases (EC 3.4.19.12) that catalyze the thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin, a small regulatory protein that can be conjugated to a large range of target proteins. Protein ubiquitination is a post-translational modification of mostly Lys residues that regulates many cellular processes, including protein degradation, intracellular trafficking, cell signaling, autophagy, transcription, translation, and the DNA damage response. These DUBs may play important regulatory roles at the level of protein turnover by preventing degradation.


Pssm-ID: 438581 [Multi-domain]  Cd Length: 128  Bit Score: 56.29  E-value: 1.71e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980903  79 CKGEGSLLFEAASMLLWGDAGLSLELRARTVVEMLLHRHYYLQGMidskvmlqavryslcseespemtsLPPATLEAIFD 158
Cdd:cd22744    5 VPGDGNCLFRALAHALYGDQESHRELRQEVVDYLRENPDLYEPAE------------------------LADEDDGEDFD 60
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767980903 159 ADVKASCFPSSFSNVWHLYALASVLQRNIYSIYPMRNlkirpYFNRVIRPRRCDHVPSTLHIMWAGQpltSHF 231
Cdd:cd22744   61 EYLQRMRKPGTWGGELELQALANALNVPIVVYSEDGG-----FLPVSVFGPGPGPSGRPIHLLYTGG---NHY 125
transpos_IS481 NF033577
IS481 family transposase; null
271-305 9.40e-03

IS481 family transposase; null


Pssm-ID: 411202 [Multi-domain]  Cd Length: 283  Bit Score: 38.73  E-value: 9.40e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 767980903 271 LELLNR--EPGLSYSHLCERYSVTKSTFYRWRRQSQE 305
Cdd:NF033577   3 LELVRLvlEDGWSVREAARRFGISRKTVYKWLKRYRA 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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