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Conserved domains on  [gi|767982005|ref|XP_011535665|]
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neurexin 3 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
911-1039 4.51e-34

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 127.54  E-value: 4.51e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767982005   911 FKTTSPDGFILFNSGDGNDFIAVELVKGYIHYVFDLGNGPNVIKgNSDRPLNDNQWHNVVITRDNsNTHSLKVDTKVVTQ 990
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYDLGSGPESLL-SSGKNLNDGQWHSVRVERNG-NTLTLSVDGQTVVS 78
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 767982005   991 VINGAKN--LDLKGDLYMAGLaqgMYSNLPKLVASRDGFQGCLASVDLNGR 1039
Cdd:pfam02210   79 SLPPGESllLNLNGPLYLGGL---PPLLLLPALPVRAGFVGCIRDVRVNGE 126
LamG smart00282
Laminin G domain;
286-425 8.23e-32

Laminin G domain;


:

Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 121.29  E-value: 8.23e-32
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767982005    286 EITLSFKTWQRNGLILHTGKSA--DYVNLALKDGAVSLVINLGSGafEAIVEPVNGKFNDNAWHDVKVTRNLRQhsgigh 363
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGggDYLALELRDGRLVLRYDLGSG--PARLTSDPTPLNDGQWHRVAVERNGRS------ 72
                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767982005    364 amVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNN 425
Cdd:smart00282   73 --VTLSVDGGNRVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPVTPGFRGCIRNLKVNGK 132
LamG smart00282
Laminin G domain;
482-631 2.38e-30

Laminin G domain;


:

Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 117.06  E-value: 2.38e-30
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767982005    482 SISFDFRTTEPNGLILFTHGKPQerkdarsqkntkVDFFAVELLDGNLYLLLDMGSGTIKVKATQKKANDGEWYHVDIQR 561
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGG------------GDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVER 68
                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767982005    562 DGRSGTISVN-SRRTPFTASGESEILDLEGDMYLGGLPENRAGLILPTelwtamlNYGYVGCIRDLFIDGR 631
Cdd:smart00282   69 NGRSVTLSVDgGNRVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPV-------TPGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
35-181 5.06e-29

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 114.05  E-value: 5.06e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767982005   35 NQWARYLRWDA-STRSDLSFQFKTNVSTGLLLYLDDGGVCDFLCLSLVDGRVQLRFSMDCAETAVLSNKQVNDSSWHFLM 113
Cdd:cd00110     7 SSYVRLPTLPApRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLGSGSLVLSSKTPLNDGQWHSVS 86
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767982005  114 VSRDRLRTVLMLDGEGQ-SGELQPQRPYMDVVSDLFLGGVPTDIRPSALTLdgvqaMPGFKGLILDLKY 181
Cdd:cd00110    87 VERNGRSVTLSVDGERVvESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPV-----SPGFVGCIRDLKV 150
LamG smart00282
Laminin G domain;
720-854 1.34e-21

Laminin G domain;


:

Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 92.02  E-value: 1.34e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767982005    720 DVSFRFMSQRAYGLLVATTSRDSADTLRLELDGGRVKLMVNLDCirincnsskGPETLYAGQ-KLNDNEWHTVRVVRRGK 798
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGS---------GPARLTSDPtPLNDGQWHRVAVERNGR 71
                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767982005    799 SLKLTVDD-DVAEGTMVGDHTRLEFH-NIETG--IMTEKRYISVVPSSFIGHLQSLMFNG 854
Cdd:smart00282   72 SVTLSVDGgNRVSGESPGGLTILNLDgPLYLGglPEDLKLPPLPVTPGFRGCIRNLKVNG 131
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
1103-1282 6.36e-21

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 90.94  E-value: 6.36e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767982005 1103 TYIFGKSGGLILYTWPAndrpSTRSDRLAVGFSTTVKDGILVRIDSAPGlGDFLQLHIEQGKIGVVFNIGTVDISIKEEr 1182
Cdd:cd00110     1 GVSFSGSSYVRLPTLPA----PRTRLSISFSFRTTSPNGLLLYAGSQNG-GDFLALELEDGRLVLRYDLGSGSLVLSSK- 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767982005 1183 TPVNDGKYHVVRFTRNGGNATLQVDNWPVNEHyptgntdnerfqmvkqkipfkynrpveewlqEKGRQLTIFNTQAQIAI 1262
Cdd:cd00110    75 TPLNDGQWHSVSVERNGRSVTLSVDGERVVES-------------------------------GSPGGSALLNLDGPLYL 123
                         170       180
                  ....*....|....*....|
gi 767982005 1263 GGKDKGRLFQGQLSGLYYDG 1282
Cdd:cd00110   124 GGLPEDLKSPGLPVSPGFVG 143
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
659-692 1.00e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.86  E-value: 1.00e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 767982005  659 CDSY-PCKNNAVCKDGWNRFICDCTgTGYWGRTCE 692
Cdd:cd00054     5 CASGnPCQNGGTCVNTVGSYRCSCP-PGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
202-232 1.41e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 43.14  E-value: 1.41e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 767982005   202 CGERPCENGGICFLLDGHPTCDCStTGYGGK 232
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP-EGYTGK 30
4.1m super family cl02555
putative band 4.1 homologues' binding motif;
1633-1651 3.22e-03

putative band 4.1 homologues' binding motif;


The actual alignment was detected with superfamily member smart00294:

Pssm-ID: 128590  Cd Length: 19  Bit Score: 36.35  E-value: 3.22e-03
                            10
                    ....*....|....*....
gi 767982005   1633 MYKYRNRDEGSYQVDETRN 1651
Cdd:smart00294    1 MYRYKHRDEGSYHTHEPKG 19
Syndecan super family cl20212
Syndecan domain; Syndecans are transmembrane heparin sulfate proteoglycans which are ...
1613-1669 5.43e-03

Syndecan domain; Syndecans are transmembrane heparin sulfate proteoglycans which are implicated in the binding of extracellular matrix components and growth factors.


The actual alignment was detected with superfamily member pfam01034:

Pssm-ID: 460035  Cd Length: 63  Bit Score: 36.99  E-value: 5.43e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 767982005  1613 GMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDETRnyisnsaQSNGTLMKEKQQ 1669
Cdd:pfam01034   11 AVIGGGVVGLLFAVLLVMFLVYRMKKKDEGSYALDEPK-------QANNYYTKAPTK 60
 
Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
911-1039 4.51e-34

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 127.54  E-value: 4.51e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767982005   911 FKTTSPDGFILFNSGDGNDFIAVELVKGYIHYVFDLGNGPNVIKgNSDRPLNDNQWHNVVITRDNsNTHSLKVDTKVVTQ 990
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYDLGSGPESLL-SSGKNLNDGQWHSVRVERNG-NTLTLSVDGQTVVS 78
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 767982005   991 VINGAKN--LDLKGDLYMAGLaqgMYSNLPKLVASRDGFQGCLASVDLNGR 1039
Cdd:pfam02210   79 SLPPGESllLNLNGPLYLGGL---PPLLLLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
884-1037 5.88e-32

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 122.53  E-value: 5.88e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767982005  884 PVTFkTKSSYLSLATLQA-YTSMHLFFQFKTTSPDGFILFN-SGDGNDFIAVELVKGYIHYVFDLGNGPNVIKgnSDRPL 961
Cdd:cd00110     1 GVSF-SGSSYVRLPTLPApRTRLSISFSFRTTSPNGLLLYAgSQNGGDFLALELEDGRLVLRYDLGSGSLVLS--SKTPL 77
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767982005  962 NDNQWHNVVITRDNSNTHsLKVDTKVVTQVINGAKN--LDLKGDLYMAGLAQGMysnLPKLVASRDGFQGCLASVDLN 1037
Cdd:cd00110    78 NDGQWHSVSVERNGRSVT-LSVDGERVVESGSPGGSalLNLDGPLYLGGLPEDL---KSPGLPVSPGFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
286-425 8.23e-32

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 121.29  E-value: 8.23e-32
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767982005    286 EITLSFKTWQRNGLILHTGKSA--DYVNLALKDGAVSLVINLGSGafEAIVEPVNGKFNDNAWHDVKVTRNLRQhsgigh 363
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGggDYLALELRDGRLVLRYDLGSG--PARLTSDPTPLNDGQWHRVAVERNGRS------ 72
                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767982005    364 amVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNN 425
Cdd:smart00282   73 --VTLSVDGGNRVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPVTPGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
262-422 2.37e-31

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 120.99  E-value: 2.37e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767982005  262 VATFRGSEYLCYDLSQNPIQSSSdeITLSFKTWQRNGLILHTG--KSADYVNLALKDGAVSLVINLGSGafEAIVEPVNg 339
Cdd:cd00110     1 GVSFSGSSYVRLPTLPAPRTRLS--ISFSFRTTSPNGLLLYAGsqNGGDFLALELEDGRLVLRYDLGSG--SLVLSSKT- 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767982005  340 KFNDNAWHDVKVTRNLRQhsgighamVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKE 419
Cdd:cd00110    76 PLNDGQWHSVSVERNGRS--------VTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPVSPGFVGCIRD 147

                  ...
gi 767982005  420 VVY 422
Cdd:cd00110   148 LKV 150
LamG smart00282
Laminin G domain;
482-631 2.38e-30

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 117.06  E-value: 2.38e-30
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767982005    482 SISFDFRTTEPNGLILFTHGKPQerkdarsqkntkVDFFAVELLDGNLYLLLDMGSGTIKVKATQKKANDGEWYHVDIQR 561
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGG------------GDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVER 68
                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767982005    562 DGRSGTISVN-SRRTPFTASGESEILDLEGDMYLGGLPENRAGLILPTelwtamlNYGYVGCIRDLFIDGR 631
Cdd:smart00282   69 NGRSVTLSVDgGNRVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPV-------TPGFRGCIRNLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
291-422 5.19e-30

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 115.98  E-value: 5.19e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767982005   291 FKTWQRNGLILHTG-KSADYVNLALKDGAVSLVINLGSGAFEAIVEPVNgkFNDNAWHDVKVTRNLRqhsgighaMVTIS 369
Cdd:pfam02210    1 FRTRQPNGLLLYAGgGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKN--LNDGQWHSVRVERNGN--------TLTLS 70
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 767982005   370 VDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVY 422
Cdd:pfam02210   71 VDGQTVVSSLPPGESLLLNLNGPLYLGGLPPLLLLPALPVRAGFVGCIRDVRV 123
LamG smart00282
Laminin G domain;
906-1039 2.39e-29

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 114.36  E-value: 2.39e-29
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767982005    906 HLFFQFKTTSPDGFILFN-SGDGNDFIAVELVKGYIHYVFDLGNGPNVIKgNSDRPLNDNQWHNVVITRDNSNTHsLKVD 984
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAgSKGGGDYLALELRDGRLVLRYDLGSGPARLT-SDPTPLNDGQWHRVAVERNGRSVT-LSVD 78
                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 767982005    985 -TKVVTQVINGAK-NLDLKGDLYMAGLAQgmySNLPKLVASRDGFQGCLASVDLNGR 1039
Cdd:smart00282   79 gGNRVSGESPGGLtILNLDGPLYLGGLPE---DLKLPPLPVTPGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
35-181 5.06e-29

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 114.05  E-value: 5.06e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767982005   35 NQWARYLRWDA-STRSDLSFQFKTNVSTGLLLYLDDGGVCDFLCLSLVDGRVQLRFSMDCAETAVLSNKQVNDSSWHFLM 113
Cdd:cd00110     7 SSYVRLPTLPApRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLGSGSLVLSSKTPLNDGQWHSVS 86
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767982005  114 VSRDRLRTVLMLDGEGQ-SGELQPQRPYMDVVSDLFLGGVPTDIRPSALTLdgvqaMPGFKGLILDLKY 181
Cdd:cd00110    87 VERNGRSVTLSVDGERVvESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPV-----SPGFVGCIRDLKV 150
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
460-629 5.91e-29

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 114.05  E-value: 5.91e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767982005  460 PINFETPeAYISLPKW-NTKRMGSISFDFRTTEPNGLILFTHGKPQErkdarsqkntkvDFFAVELLDGNLYLLLDMGSG 538
Cdd:cd00110     1 GVSFSGS-SYVRLPTLpAPRTRLSISFSFRTTSPNGLLLYAGSQNGG------------DFLALELEDGRLVLRYDLGSG 67
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767982005  539 TIKVKATQKKaNDGEWYHVDIQRDGRSGTISVNSRRT-PFTASGESEILDLEGDMYLGGLPENRAGLILPTelwtamlNY 617
Cdd:cd00110    68 SLVLSSKTPL-NDGQWHSVSVERNGRSVTLSVDGERVvESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPV-------SP 139
                         170
                  ....*....|..
gi 767982005  618 GYVGCIRDLFID 629
Cdd:cd00110   140 GFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
50-183 1.95e-27

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 108.97  E-value: 1.95e-27
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767982005     50 DLSFQFKTNVSTGLLLYLDDGGVCDFLCLSLVDGRVQLRFSMDCAETAVLS-NKQVNDSSWHFLMVSRDRLRTVLMLDGE 128
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGSGPARLTSdPTPLNDGQWHRVAVERNGRSVTLSVDGG 80
                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 767982005    129 G-QSGELQPQRPYMDVVSDLFLGGVPTDIRPSALTLDgvqamPGFKGLILDLKYGN 183
Cdd:smart00282   81 NrVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPVT-----PGFRGCIRNLKVNG 131
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
487-631 1.01e-25

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 103.65  E-value: 1.01e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767982005   487 FRTTEPNGLILFTHGKPQerkdarsqkntkvDFFAVELLDGNLYLLLDMGSGTIKVKATQKKANDGEWYHVDIQRDGRSG 566
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGS-------------DFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTL 67
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767982005   567 TISVNSRRT-PFTASGESEILDLEGDMYLGGLPEnraglilPTELWTAMLNYGYVGCIRDLFIDGR 631
Cdd:pfam02210   68 TLSVDGQTVvSSLPPGESLLLNLNGPLYLGGLPP-------LLLLPALPVRAGFVGCIRDVRVNGE 126
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
55-183 1.34e-24

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 100.57  E-value: 1.34e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767982005    55 FKTNVSTGLLLYLDDGGvCDFLCLSLVDGRVQLRFSMDCAETAVLS-NKQVNDSSWHFLMVSRDRLRTVLMLDGEGQSGE 133
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGG-SDFLALELVNGRLVLRYDLGSGPESLLSsGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSS 79
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 767982005   134 LQPQRPY-MDVVSDLFLGGVPTDirpsaLTLDGVQAMPGFKGLILDLKYGN 183
Cdd:pfam02210   80 LPPGESLlLNLNGPLYLGGLPPL-----LLLPALPVRAGFVGCIRDVRVNG 125
LamG smart00282
Laminin G domain;
720-854 1.34e-21

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 92.02  E-value: 1.34e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767982005    720 DVSFRFMSQRAYGLLVATTSRDSADTLRLELDGGRVKLMVNLDCirincnsskGPETLYAGQ-KLNDNEWHTVRVVRRGK 798
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGS---------GPARLTSDPtPLNDGQWHRVAVERNGR 71
                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767982005    799 SLKLTVDD-DVAEGTMVGDHTRLEFH-NIETG--IMTEKRYISVVPSSFIGHLQSLMFNG 854
Cdd:smart00282   72 SVTLSVDGgNRVSGESPGGLTILNLDgPLYLGglPEDLKLPPLPVTPGFRGCIRNLKVNG 131
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
1103-1282 6.36e-21

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 90.94  E-value: 6.36e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767982005 1103 TYIFGKSGGLILYTWPAndrpSTRSDRLAVGFSTTVKDGILVRIDSAPGlGDFLQLHIEQGKIGVVFNIGTVDISIKEEr 1182
Cdd:cd00110     1 GVSFSGSSYVRLPTLPA----PRTRLSISFSFRTTSPNGLLLYAGSQNG-GDFLALELEDGRLVLRYDLGSGSLVLSSK- 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767982005 1183 TPVNDGKYHVVRFTRNGGNATLQVDNWPVNEHyptgntdnerfqmvkqkipfkynrpveewlqEKGRQLTIFNTQAQIAI 1262
Cdd:cd00110    75 TPLNDGQWHSVSVERNGRSVTLSVDGERVVES-------------------------------GSPGGSALLNLDGPLYL 123
                         170       180
                  ....*....|....*....|
gi 767982005 1263 GGKDKGRLFQGQLSGLYYDG 1282
Cdd:cd00110   124 GGLPEDLKSPGLPVSPGFVG 143
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
1134-1282 1.19e-19

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 86.32  E-value: 1.19e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767982005  1134 FSTTVKDGILvrIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDNWPVNE 1213
Cdd:pfam02210    1 FRTRQPNGLL--LYAGGGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVS 78
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767982005  1214 HYPTGNTDnerfqmvkqkipfkynrpveewlqekgrqltIFNTQAQIAIGGKDKGRL---------FQGQLSGLYYDG 1282
Cdd:pfam02210   79 SLPPGESL-------------------------------LLNLNGPLYLGGLPPLLLlpalpvragFVGCIRDVRVNG 125
LamG smart00282
Laminin G domain;
1129-1282 2.88e-19

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 85.47  E-value: 2.88e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767982005   1129 RLAVGFSTTVKDGILVRIDSAPGlGDFLQLHIEQGKIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDN 1208
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGG-GDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDG 79
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767982005   1209 -WPVNEHYPTGntdnerfqmvkqkipfkynrpveewlqekgrqLTIFNTQAQIAIGGKDKGRL---------FQGQLSGL 1278
Cdd:smart00282   80 gNRVSGESPGG--------------------------------LTILNLDGPLYLGGLPEDLKlpplpvtpgFRGCIRNL 127

                    ....
gi 767982005   1279 YYDG 1282
Cdd:smart00282  128 KVNG 131
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
725-854 5.17e-18

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 81.70  E-value: 5.17e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767982005   725 FMSQRAYGLLVATTSRDSaDTLRLELDGGRVKLMVNLdcirincnSSKGPETLYAGQKLNDNEWHTVRVVRRGKSLKLTV 804
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGS-DFLALELVNGRLVLRYDL--------GSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSV 71
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 767982005   805 DDDVAEGTMvgDHTRLEFHNIETGI------MTEKRYISVVPSSFIGHLQSLMFNG 854
Cdd:pfam02210   72 DGQTVVSSL--PPGESLLLNLNGPLylgglpPLLLLPALPVRAGFVGCIRDVRVNG 125
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
698-853 6.42e-16

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 76.69  E-value: 6.42e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767982005  698 LSYDGSMYMKIIMPMVMHTEaEDVSFRFMSQRAYGLLVATTSRDSADTLRLELDGGRVKLMVNLdcirincnsSKGPETL 777
Cdd:cd00110     2 VSFSGSSYVRLPTLPAPRTR-LSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDL---------GSGSLVL 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767982005  778 YAGQKLNDNEWHTVRVVRRGKSLKLTVDDD-VAEGTMVGDHTRLefhNIETGI------MTEKRYISVVPSSFIGHLQSL 850
Cdd:cd00110    72 SSKTPLNDGQWHSVSVERNGRSVTLSVDGErVVESGSPGGSALL---NLDGPLylgglpEDLKSPGLPVSPGFVGCIRDL 148

                  ...
gi 767982005  851 MFN 853
Cdd:cd00110   149 KVN 151
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
659-692 1.00e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.86  E-value: 1.00e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 767982005  659 CDSY-PCKNNAVCKDGWNRFICDCTgTGYWGRTCE 692
Cdd:cd00054     5 CASGnPCQNGGTCVNTVGSYRCSCP-PGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
202-232 1.41e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 43.14  E-value: 1.41e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 767982005   202 CGERPCENGGICFLLDGHPTCDCStTGYGGK 232
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP-EGYTGK 30
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
659-690 6.73e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.21  E-value: 6.73e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 767982005   659 CDSYPCKNNAVCKDGWNRFICDCTgTGYWGRT 690
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP-EGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
659-692 1.38e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 1.38e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 767982005    659 CDSY-PCKNNAVCKDGWNRFICDCtGTGYW-GRTCE 692
Cdd:smart00179    5 CASGnPCQNGGTCVNTVGSYRCEC-PPGYTdGRNCE 39
4.1m smart00294
putative band 4.1 homologues' binding motif;
1633-1651 3.22e-03

putative band 4.1 homologues' binding motif;


Pssm-ID: 128590  Cd Length: 19  Bit Score: 36.35  E-value: 3.22e-03
                            10
                    ....*....|....*....
gi 767982005   1633 MYKYRNRDEGSYQVDETRN 1651
Cdd:smart00294    1 MYRYKHRDEGSYHTHEPKG 19
Syndecan pfam01034
Syndecan domain; Syndecans are transmembrane heparin sulfate proteoglycans which are ...
1613-1669 5.43e-03

Syndecan domain; Syndecans are transmembrane heparin sulfate proteoglycans which are implicated in the binding of extracellular matrix components and growth factors.


Pssm-ID: 460035  Cd Length: 63  Bit Score: 36.99  E-value: 5.43e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 767982005  1613 GMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDETRnyisnsaQSNGTLMKEKQQ 1669
Cdd:pfam01034   11 AVIGGGVVGLLFAVLLVMFLVYRMKKKDEGSYALDEPK-------QANNYYTKAPTK 60
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
206-234 6.69e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 6.69e-03
                          10        20
                  ....*....|....*....|....*....
gi 767982005  206 PCENGGICFLLDGHPTCDCStTGYGGKLC 234
Cdd:cd00054    10 PCQNGGTCVNTVGSYRCSCP-PGYTGRNC 37
 
Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
911-1039 4.51e-34

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 127.54  E-value: 4.51e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767982005   911 FKTTSPDGFILFNSGDGNDFIAVELVKGYIHYVFDLGNGPNVIKgNSDRPLNDNQWHNVVITRDNsNTHSLKVDTKVVTQ 990
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYDLGSGPESLL-SSGKNLNDGQWHSVRVERNG-NTLTLSVDGQTVVS 78
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 767982005   991 VINGAKN--LDLKGDLYMAGLaqgMYSNLPKLVASRDGFQGCLASVDLNGR 1039
Cdd:pfam02210   79 SLPPGESllLNLNGPLYLGGL---PPLLLLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
884-1037 5.88e-32

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 122.53  E-value: 5.88e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767982005  884 PVTFkTKSSYLSLATLQA-YTSMHLFFQFKTTSPDGFILFN-SGDGNDFIAVELVKGYIHYVFDLGNGPNVIKgnSDRPL 961
Cdd:cd00110     1 GVSF-SGSSYVRLPTLPApRTRLSISFSFRTTSPNGLLLYAgSQNGGDFLALELEDGRLVLRYDLGSGSLVLS--SKTPL 77
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767982005  962 NDNQWHNVVITRDNSNTHsLKVDTKVVTQVINGAKN--LDLKGDLYMAGLAQGMysnLPKLVASRDGFQGCLASVDLN 1037
Cdd:cd00110    78 NDGQWHSVSVERNGRSVT-LSVDGERVVESGSPGGSalLNLDGPLYLGGLPEDL---KSPGLPVSPGFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
286-425 8.23e-32

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 121.29  E-value: 8.23e-32
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767982005    286 EITLSFKTWQRNGLILHTGKSA--DYVNLALKDGAVSLVINLGSGafEAIVEPVNGKFNDNAWHDVKVTRNLRQhsgigh 363
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGggDYLALELRDGRLVLRYDLGSG--PARLTSDPTPLNDGQWHRVAVERNGRS------ 72
                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767982005    364 amVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNN 425
Cdd:smart00282   73 --VTLSVDGGNRVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPVTPGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
262-422 2.37e-31

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 120.99  E-value: 2.37e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767982005  262 VATFRGSEYLCYDLSQNPIQSSSdeITLSFKTWQRNGLILHTG--KSADYVNLALKDGAVSLVINLGSGafEAIVEPVNg 339
Cdd:cd00110     1 GVSFSGSSYVRLPTLPAPRTRLS--ISFSFRTTSPNGLLLYAGsqNGGDFLALELEDGRLVLRYDLGSG--SLVLSSKT- 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767982005  340 KFNDNAWHDVKVTRNLRQhsgighamVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKE 419
Cdd:cd00110    76 PLNDGQWHSVSVERNGRS--------VTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPVSPGFVGCIRD 147

                  ...
gi 767982005  420 VVY 422
Cdd:cd00110   148 LKV 150
LamG smart00282
Laminin G domain;
482-631 2.38e-30

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 117.06  E-value: 2.38e-30
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767982005    482 SISFDFRTTEPNGLILFTHGKPQerkdarsqkntkVDFFAVELLDGNLYLLLDMGSGTIKVKATQKKANDGEWYHVDIQR 561
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGG------------GDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVER 68
                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767982005    562 DGRSGTISVN-SRRTPFTASGESEILDLEGDMYLGGLPENRAGLILPTelwtamlNYGYVGCIRDLFIDGR 631
Cdd:smart00282   69 NGRSVTLSVDgGNRVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPV-------TPGFRGCIRNLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
291-422 5.19e-30

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 115.98  E-value: 5.19e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767982005   291 FKTWQRNGLILHTG-KSADYVNLALKDGAVSLVINLGSGAFEAIVEPVNgkFNDNAWHDVKVTRNLRqhsgighaMVTIS 369
Cdd:pfam02210    1 FRTRQPNGLLLYAGgGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKN--LNDGQWHSVRVERNGN--------TLTLS 70
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 767982005   370 VDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVY 422
Cdd:pfam02210   71 VDGQTVVSSLPPGESLLLNLNGPLYLGGLPPLLLLPALPVRAGFVGCIRDVRV 123
LamG smart00282
Laminin G domain;
906-1039 2.39e-29

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 114.36  E-value: 2.39e-29
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767982005    906 HLFFQFKTTSPDGFILFN-SGDGNDFIAVELVKGYIHYVFDLGNGPNVIKgNSDRPLNDNQWHNVVITRDNSNTHsLKVD 984
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAgSKGGGDYLALELRDGRLVLRYDLGSGPARLT-SDPTPLNDGQWHRVAVERNGRSVT-LSVD 78
                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 767982005    985 -TKVVTQVINGAK-NLDLKGDLYMAGLAQgmySNLPKLVASRDGFQGCLASVDLNGR 1039
Cdd:smart00282   79 gGNRVSGESPGGLtILNLDGPLYLGGLPE---DLKLPPLPVTPGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
35-181 5.06e-29

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 114.05  E-value: 5.06e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767982005   35 NQWARYLRWDA-STRSDLSFQFKTNVSTGLLLYLDDGGVCDFLCLSLVDGRVQLRFSMDCAETAVLSNKQVNDSSWHFLM 113
Cdd:cd00110     7 SSYVRLPTLPApRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLGSGSLVLSSKTPLNDGQWHSVS 86
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767982005  114 VSRDRLRTVLMLDGEGQ-SGELQPQRPYMDVVSDLFLGGVPTDIRPSALTLdgvqaMPGFKGLILDLKY 181
Cdd:cd00110    87 VERNGRSVTLSVDGERVvESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPV-----SPGFVGCIRDLKV 150
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
460-629 5.91e-29

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 114.05  E-value: 5.91e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767982005  460 PINFETPeAYISLPKW-NTKRMGSISFDFRTTEPNGLILFTHGKPQErkdarsqkntkvDFFAVELLDGNLYLLLDMGSG 538
Cdd:cd00110     1 GVSFSGS-SYVRLPTLpAPRTRLSISFSFRTTSPNGLLLYAGSQNGG------------DFLALELEDGRLVLRYDLGSG 67
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767982005  539 TIKVKATQKKaNDGEWYHVDIQRDGRSGTISVNSRRT-PFTASGESEILDLEGDMYLGGLPENRAGLILPTelwtamlNY 617
Cdd:cd00110    68 SLVLSSKTPL-NDGQWHSVSVERNGRSVTLSVDGERVvESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPV-------SP 139
                         170
                  ....*....|..
gi 767982005  618 GYVGCIRDLFID 629
Cdd:cd00110   140 GFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
50-183 1.95e-27

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 108.97  E-value: 1.95e-27
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767982005     50 DLSFQFKTNVSTGLLLYLDDGGVCDFLCLSLVDGRVQLRFSMDCAETAVLS-NKQVNDSSWHFLMVSRDRLRTVLMLDGE 128
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGSGPARLTSdPTPLNDGQWHRVAVERNGRSVTLSVDGG 80
                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 767982005    129 G-QSGELQPQRPYMDVVSDLFLGGVPTDIRPSALTLDgvqamPGFKGLILDLKYGN 183
Cdd:smart00282   81 NrVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPVT-----PGFRGCIRNLKVNG 131
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
487-631 1.01e-25

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 103.65  E-value: 1.01e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767982005   487 FRTTEPNGLILFTHGKPQerkdarsqkntkvDFFAVELLDGNLYLLLDMGSGTIKVKATQKKANDGEWYHVDIQRDGRSG 566
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGS-------------DFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTL 67
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767982005   567 TISVNSRRT-PFTASGESEILDLEGDMYLGGLPEnraglilPTELWTAMLNYGYVGCIRDLFIDGR 631
Cdd:pfam02210   68 TLSVDGQTVvSSLPPGESLLLNLNGPLYLGGLPP-------LLLLPALPVRAGFVGCIRDVRVNGE 126
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
55-183 1.34e-24

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 100.57  E-value: 1.34e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767982005    55 FKTNVSTGLLLYLDDGGvCDFLCLSLVDGRVQLRFSMDCAETAVLS-NKQVNDSSWHFLMVSRDRLRTVLMLDGEGQSGE 133
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGG-SDFLALELVNGRLVLRYDLGSGPESLLSsGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSS 79
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 767982005   134 LQPQRPY-MDVVSDLFLGGVPTDirpsaLTLDGVQAMPGFKGLILDLKYGN 183
Cdd:pfam02210   80 LPPGESLlLNLNGPLYLGGLPPL-----LLLPALPVRAGFVGCIRDVRVNG 125
Laminin_G_1 pfam00054
Laminin G domain;
911-1039 3.53e-22

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 93.92  E-value: 3.53e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767982005   911 FKTTSPDGFILFN-SGDGNDFIAVELVKGYIHYVFDLGNGPNVIKGNSdrPLNDNQWHNVVITRDNSNThSLKVD---TK 986
Cdd:pfam00054    1 FRTTEPSGLLLYNgTQTERDFLALELRDGRLEVSYDLGSGAAVVRSGD--KLNDGKWHSVELERNGRSG-TLSVDgeaRP 77
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 767982005   987 VVTQVINGAKNLDLKGDLYMAGLAQGMYSNLPKlvASRDGFQGCLASVDLNGR 1039
Cdd:pfam00054   78 TGESPLGATTDLDVDGPLYVGGLPSLGVKKRRL--AISPSFDGCIRDVIVNGK 128
LamG smart00282
Laminin G domain;
720-854 1.34e-21

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 92.02  E-value: 1.34e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767982005    720 DVSFRFMSQRAYGLLVATTSRDSADTLRLELDGGRVKLMVNLDCirincnsskGPETLYAGQ-KLNDNEWHTVRVVRRGK 798
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGS---------GPARLTSDPtPLNDGQWHRVAVERNGR 71
                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767982005    799 SLKLTVDD-DVAEGTMVGDHTRLEFH-NIETG--IMTEKRYISVVPSSFIGHLQSLMFNG 854
Cdd:smart00282   72 SVTLSVDGgNRVSGESPGGLTILNLDgPLYLGglPEDLKLPPLPVTPGFRGCIRNLKVNG 131
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
1103-1282 6.36e-21

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 90.94  E-value: 6.36e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767982005 1103 TYIFGKSGGLILYTWPAndrpSTRSDRLAVGFSTTVKDGILVRIDSAPGlGDFLQLHIEQGKIGVVFNIGTVDISIKEEr 1182
Cdd:cd00110     1 GVSFSGSSYVRLPTLPA----PRTRLSISFSFRTTSPNGLLLYAGSQNG-GDFLALELEDGRLVLRYDLGSGSLVLSSK- 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767982005 1183 TPVNDGKYHVVRFTRNGGNATLQVDNWPVNEHyptgntdnerfqmvkqkipfkynrpveewlqEKGRQLTIFNTQAQIAI 1262
Cdd:cd00110    75 TPLNDGQWHSVSVERNGRSVTLSVDGERVVES-------------------------------GSPGGSALLNLDGPLYL 123
                         170       180
                  ....*....|....*....|
gi 767982005 1263 GGKDKGRLFQGQLSGLYYDG 1282
Cdd:cd00110   124 GGLPEDLKSPGLPVSPGFVG 143
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
1134-1282 1.19e-19

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 86.32  E-value: 1.19e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767982005  1134 FSTTVKDGILvrIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDNWPVNE 1213
Cdd:pfam02210    1 FRTRQPNGLL--LYAGGGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVS 78
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767982005  1214 HYPTGNTDnerfqmvkqkipfkynrpveewlqekgrqltIFNTQAQIAIGGKDKGRL---------FQGQLSGLYYDG 1282
Cdd:pfam02210   79 SLPPGESL-------------------------------LLNLNGPLYLGGLPPLLLlpalpvragFVGCIRDVRVNG 125
Laminin_G_1 pfam00054
Laminin G domain;
487-631 2.87e-19

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 85.45  E-value: 2.87e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767982005   487 FRTTEPNGLILFThgkpqerkdarsQKNTKVDFFAVELLDGNLYLLLDMGSGTIKVKATQkKANDGEWYHVDIQRDGRSG 566
Cdd:pfam00054    1 FRTTEPSGLLLYN------------GTQTERDFLALELRDGRLEVSYDLGSGAAVVRSGD-KLNDGKWHSVELERNGRSG 67
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767982005   567 TISVNSRRTPFTAS--GESEILDLEGDMYLGGLPEnragliLPTELWTAMLNYGYVGCIRDLFIDGR 631
Cdd:pfam00054   68 TLSVDGEARPTGESplGATTDLDVDGPLYVGGLPS------LGVKKRRLAISPSFDGCIRDVIVNGK 128
LamG smart00282
Laminin G domain;
1129-1282 2.88e-19

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 85.47  E-value: 2.88e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767982005   1129 RLAVGFSTTVKDGILVRIDSAPGlGDFLQLHIEQGKIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDN 1208
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGG-GDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDG 79
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767982005   1209 -WPVNEHYPTGntdnerfqmvkqkipfkynrpveewlqekgrqLTIFNTQAQIAIGGKDKGRL---------FQGQLSGL 1278
Cdd:smart00282   80 gNRVSGESPGG--------------------------------LTILNLDGPLYLGGLPEDLKlpplpvtpgFRGCIRNL 127

                    ....
gi 767982005   1279 YYDG 1282
Cdd:smart00282  128 KVNG 131
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
725-854 5.17e-18

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 81.70  E-value: 5.17e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767982005   725 FMSQRAYGLLVATTSRDSaDTLRLELDGGRVKLMVNLdcirincnSSKGPETLYAGQKLNDNEWHTVRVVRRGKSLKLTV 804
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGS-DFLALELVNGRLVLRYDL--------GSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSV 71
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 767982005   805 DDDVAEGTMvgDHTRLEFHNIETGI------MTEKRYISVVPSSFIGHLQSLMFNG 854
Cdd:pfam02210   72 DGQTVVSSL--PPGESLLLNLNGPLylgglpPLLLLPALPVRAGFVGCIRDVRVNG 125
Laminin_G_1 pfam00054
Laminin G domain;
291-424 1.51e-17

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 80.44  E-value: 1.51e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767982005   291 FKTWQRNGLILHTGKSA--DYVNLALKDGAVSLVINLGSGAfeaIVEPVNGKFNDNAWHDVKVTRNLRQhsgighamVTI 368
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTerDFLALELRDGRLEVSYDLGSGA---AVVRSGDKLNDGKWHSVELERNGRS--------GTL 69
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 767982005   369 SVDGILTTTGYTQEDYTMLGS-DDFFYVGGSPSTADLP-GSPVSNNFMGCLKEVVYKN 424
Cdd:pfam00054   70 SVDGEARPTGESPLGATTDLDvDGPLYVGGLPSLGVKKrRLAISPSFDGCIRDVIVNG 127
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
698-853 6.42e-16

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 76.69  E-value: 6.42e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767982005  698 LSYDGSMYMKIIMPMVMHTEaEDVSFRFMSQRAYGLLVATTSRDSADTLRLELDGGRVKLMVNLdcirincnsSKGPETL 777
Cdd:cd00110     2 VSFSGSSYVRLPTLPAPRTR-LSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDL---------GSGSLVL 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767982005  778 YAGQKLNDNEWHTVRVVRRGKSLKLTVDDD-VAEGTMVGDHTRLefhNIETGI------MTEKRYISVVPSSFIGHLQSL 850
Cdd:cd00110    72 SSKTPLNDGQWHSVSVERNGRSVTLSVDGErVVESGSPGGSALL---NLDGPLylgglpEDLKSPGLPVSPGFVGCIRDL 148

                  ...
gi 767982005  851 MFN 853
Cdd:cd00110   149 KVN 151
Laminin_G_1 pfam00054
Laminin G domain;
55-183 3.12e-11

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 62.33  E-value: 3.12e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767982005    55 FKTNVSTGLLLYLDDGGVCDFLCLSLVDGRVQLRFSMDCAETAVLSNKQVNDSSWHFLMVSRDRLRTVLMLDGEGQSGEL 134
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTERDFLALELRDGRLEVSYDLGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEARPTGE 80
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 767982005   135 QPQRPYM--DVVSDLFLGGVPTDI---RPSALTldgvqamPGFKGLILDLKYGN 183
Cdd:pfam00054   81 SPLGATTdlDVDGPLYVGGLPSLGvkkRRLAIS-------PSFDGCIRDVIVNG 127
Laminin_G_1 pfam00054
Laminin G domain;
732-854 3.65e-11

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 62.33  E-value: 3.65e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767982005   732 GLLVATTSRDSADTLRLELDGGRVKLMVNLdcirincnsSKGPETLYAGQKLNDNEWHTVRVVRRGKSLKLTVDD-DVAE 810
Cdd:pfam00054    8 GLLLYNGTQTERDFLALELRDGRLEVSYDL---------GSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDGeARPT 78
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 767982005   811 GTMVgdHTRLEFHNIETGIM-------TEKRYISVVPSSFIGHLQSLMFNG 854
Cdd:pfam00054   79 GESP--LGATTDLDVDGPLYvgglpslGVKKRRLAISPSFDGCIRDVIVNG 127
Laminin_G_1 pfam00054
Laminin G domain;
1134-1220 9.32e-07

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 49.62  E-value: 9.32e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767982005  1134 FSTTVKDGILVRIDSAPGlGDFLQLHIEQGKIGVVFNIGTVDISIKEErTPVNDGKYHVVRFTRNGGNATLQVD-NWPVN 1212
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTE-RDFLALELRDGRLEVSYDLGSGAAVVRSG-DKLNDGKWHSVELERNGRSGTLSVDgEARPT 78

                   ....*...
gi 767982005  1213 EHYPTGNT 1220
Cdd:pfam00054   79 GESPLGAT 86
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
659-692 1.00e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.86  E-value: 1.00e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 767982005  659 CDSY-PCKNNAVCKDGWNRFICDCTgTGYWGRTCE 692
Cdd:cd00054     5 CASGnPCQNGGTCVNTVGSYRCSCP-PGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
202-232 1.41e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 43.14  E-value: 1.41e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 767982005   202 CGERPCENGGICFLLDGHPTCDCStTGYGGK 232
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP-EGYTGK 30
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
659-690 6.73e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.21  E-value: 6.73e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 767982005   659 CDSYPCKNNAVCKDGWNRFICDCTgTGYWGRT 690
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP-EGYTGKR 31
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
660-692 7.57e-04

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 38.61  E-value: 7.57e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 767982005  660 DSYPCKNNAVCKDGWNRFICDCTgTGYWG-RTCE 692
Cdd:cd00053     4 ASNPCSNGGTCVNTPGSYRCVCP-PGYTGdRSCE 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
659-692 1.38e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 1.38e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 767982005    659 CDSY-PCKNNAVCKDGWNRFICDCtGTGYW-GRTCE 692
Cdd:smart00179    5 CASGnPCQNGGTCVNTVGSYRCEC-PPGYTdGRNCE 39
4.1m smart00294
putative band 4.1 homologues' binding motif;
1633-1651 3.22e-03

putative band 4.1 homologues' binding motif;


Pssm-ID: 128590  Cd Length: 19  Bit Score: 36.35  E-value: 3.22e-03
                            10
                    ....*....|....*....
gi 767982005   1633 MYKYRNRDEGSYQVDETRN 1651
Cdd:smart00294    1 MYRYKHRDEGSYHTHEPKG 19
Syndecan pfam01034
Syndecan domain; Syndecans are transmembrane heparin sulfate proteoglycans which are ...
1613-1669 5.43e-03

Syndecan domain; Syndecans are transmembrane heparin sulfate proteoglycans which are implicated in the binding of extracellular matrix components and growth factors.


Pssm-ID: 460035  Cd Length: 63  Bit Score: 36.99  E-value: 5.43e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 767982005  1613 GMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDETRnyisnsaQSNGTLMKEKQQ 1669
Cdd:pfam01034   11 AVIGGGVVGLLFAVLLVMFLVYRMKKKDEGSYALDEPK-------QANNYYTKAPTK 60
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
206-234 6.69e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 6.69e-03
                          10        20
                  ....*....|....*....|....*....
gi 767982005  206 PCENGGICFLLDGHPTCDCStTGYGGKLC 234
Cdd:cd00054    10 PCQNGGTCVNTVGSYRCSCP-PGYTGRNC 37
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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