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Conserved domains on  [gi|767937598|ref|XP_011535893|]
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proton-coupled amino acid transporter 1 isoform X3 [Homo sapiens]

Protein Classification

SLC5/6 family protein( domain architecture ID 124)

SLC5/6 (solute carrier 5/6) family protein may function as a transporter

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
SLC5-6-like_sbd super family cl00456
Solute carrier families 5 and 6-like; solute binding domain; This superfamily includes the ...
47-453 2.01e-68

Solute carrier families 5 and 6-like; solute binding domain; This superfamily includes the solute-binding domain of SLC5 proteins (also called the sodium/glucose cotransporters or solute sodium symporters), SLC6 proteins (also called the sodium- and chloride-dependent neurotransmitter transporters or Na+/Cl--dependent transporters), and nucleobase-cation-symport-1 (NCS1) transporters. SLC5s co-transport Na+ with sugars, amino acids, inorganic ions or vitamins. SLC6s include Na+/Cl--dependent plasma membrane transporters for the monoamine neurotransmitters serotonin, dopamine, and norepinephrine, and the amino acid neurotransmitters GABA and glycine. NCS1s are essential components of salvage pathways for nucleobases and related metabolites; their known substrates include allantoin, uracil, thiamine, and nicotinamide riboside. Members of this superfamily are important in human physiology and disease. They contain a functional core of 10 transmembrane helices (TMs): an inverted structural repeat, TMs1-5 and TMs6-10; TMs numbered to conform to the SLC6 Aquifex aeolicus LeuT.


The actual alignment was detected with superfamily member pfam01490:

Pssm-ID: 444915  Cd Length: 410  Bit Score: 224.11  E-value: 2.01e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767937598   47 TTWFQTLIHLLKGNIGTGLLGLPLAVKNAGIVMGPISLLIIGIVAVHCMGILVKCaHHFCRRLNKSFVDYGDTVmygles 126
Cdd:pfam01490   3 ISAWQAVFNLINAIIGAGVLSLPYAFKQLGWIPGLILLLIVGLISLYTAHLLVRC-SKEVPVTGKRNKSYGDLG------ 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767937598  127 spcswLRNHAHWGRRVVDFFLIVTQLGFCCVYFVFLADNFKQVIEaangttNNCHnnetvilTPTMDSRLYMLSFLPFLV 206
Cdd:pfam01490  76 -----YRLLGPKGRLLILFAILLNLFGVCISYLIFAGDNLPAIFD------SFFD-------TCPISLVYFIIIFGLIFI 137
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767937598  207 LLVFIRNLRALSIFSLLANITMLVSLVMIYQFIVQRIP-DPSHLPLVAPW-----KTYPLFFGTAIFSFEGIGMVLPLEN 280
Cdd:pfam01490 138 PLSFIPNLSALSILSLLAAVSSLYYIVILVLSVAEGIVlTAQGVGHLGSKtniklAGTFLAIGIIVFAFEGHAVLLPIQN 217
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767937598  281 KMKDPRKFPL---ILYLGMVIVTILYISLGCLGYLQFGANIQGSITLNLPN-CWLYQSVKLLYSIGIFFTYALQFYVPAE 356
Cdd:pfam01490 218 EMKNPSKFKAmtkILLTAIIIATVLYILIGLVGYLAFGDNVKGNILLNLPKsAWLIDIANLLLVLHVILSFPLQLFPIRQ 297
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767937598  357 II--------IPFFVSRAPEHCELVVDLFVRTVLVCLTCILAILIPRLDLVISLVGSVSSSALALIIPPLLEV----TTF 424
Cdd:pfam01490 298 IVenllfrkeAPFGASGKNNPKSKLLRVVIRSGLVVITYLIAISVPFFGDLLSLVGATSCAPLSFILPPLFHLklkkTKK 377
                         410       420
                  ....*....|....*....|....*....
gi 767937598  425 YSEGMSPLTIFKDALISILGFVGFVVGTY 453
Cdd:pfam01490 378 KSQEKLWKPDILDVICIVIGLLLMAYGVA 406
 
Name Accession Description Interval E-value
Aa_trans pfam01490
Transmembrane amino acid transporter protein; This transmembrane region is found in many amino ...
47-453 2.01e-68

Transmembrane amino acid transporter protein; This transmembrane region is found in many amino acid transporters including UNC-47 and MTR. UNC-47 encodes a vesicular amino butyric acid (GABA) transporter, (VGAT). UNC-47 is predicted to have 10 transmembrane domains. MTR is a N system amino acid transporter system protein involved in methyltryptophan resistance. Other members of this family include proline transporters and amino acid permeases.


Pssm-ID: 279788  Cd Length: 410  Bit Score: 224.11  E-value: 2.01e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767937598   47 TTWFQTLIHLLKGNIGTGLLGLPLAVKNAGIVMGPISLLIIGIVAVHCMGILVKCaHHFCRRLNKSFVDYGDTVmygles 126
Cdd:pfam01490   3 ISAWQAVFNLINAIIGAGVLSLPYAFKQLGWIPGLILLLIVGLISLYTAHLLVRC-SKEVPVTGKRNKSYGDLG------ 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767937598  127 spcswLRNHAHWGRRVVDFFLIVTQLGFCCVYFVFLADNFKQVIEaangttNNCHnnetvilTPTMDSRLYMLSFLPFLV 206
Cdd:pfam01490  76 -----YRLLGPKGRLLILFAILLNLFGVCISYLIFAGDNLPAIFD------SFFD-------TCPISLVYFIIIFGLIFI 137
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767937598  207 LLVFIRNLRALSIFSLLANITMLVSLVMIYQFIVQRIP-DPSHLPLVAPW-----KTYPLFFGTAIFSFEGIGMVLPLEN 280
Cdd:pfam01490 138 PLSFIPNLSALSILSLLAAVSSLYYIVILVLSVAEGIVlTAQGVGHLGSKtniklAGTFLAIGIIVFAFEGHAVLLPIQN 217
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767937598  281 KMKDPRKFPL---ILYLGMVIVTILYISLGCLGYLQFGANIQGSITLNLPN-CWLYQSVKLLYSIGIFFTYALQFYVPAE 356
Cdd:pfam01490 218 EMKNPSKFKAmtkILLTAIIIATVLYILIGLVGYLAFGDNVKGNILLNLPKsAWLIDIANLLLVLHVILSFPLQLFPIRQ 297
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767937598  357 II--------IPFFVSRAPEHCELVVDLFVRTVLVCLTCILAILIPRLDLVISLVGSVSSSALALIIPPLLEV----TTF 424
Cdd:pfam01490 298 IVenllfrkeAPFGASGKNNPKSKLLRVVIRSGLVVITYLIAISVPFFGDLLSLVGATSCAPLSFILPPLFHLklkkTKK 377
                         410       420
                  ....*....|....*....|....*....
gi 767937598  425 YSEGMSPLTIFKDALISILGFVGFVVGTY 453
Cdd:pfam01490 378 KSQEKLWKPDILDVICIVIGLLLMAYGVA 406
PTZ00206 PTZ00206
amino acid transporter; Provisional
61-452 1.55e-05

amino acid transporter; Provisional


Pssm-ID: 240313  Cd Length: 467  Bit Score: 47.17  E-value: 1.55e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767937598  61 IGTGLLGLPLAVKNAGIVMGPISLLIIGIVAVHCMGILVKCAHhfcrRLNKSFVDYGDTVMYGlesspcswlrnhaHWGR 140
Cdd:PTZ00206  74 VGAGIVGLPSAANSSGLVMAMIYLIIITAMTIFSIYALGVAAD----KTNIRTYEGVARVLLG-------------PWGS 136
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767937598 141 RVVDFFLIVTQLGFCCVYFVFLADNFKQVIEAANGTTNNCHNNETVILTPTMdsrlymlsFLPFLVLLVFIRNLRALSIF 220
Cdd:PTZ00206 137 YYVAATRAFHGFSACVAYVISVGDILSATLKGTNAPDFLKQKSGNRLLTSLM--------WLCFMLPLVIPRHIDSLRYV 208
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767937598 221 SLLANITML-VSLVMIYQFIVQRIPDPSHLPLVAPWKTYPLFF---------GTAIFSFEGIGMVLPLENKM----KDPR 286
Cdd:PTZ00206 209 STIAVSFMVyLVIVIVVHSCMNGLPENIKNVSVGKDDNAEIILfnsgnraieGLGVFIFAYVFQITAYEVYMdmtnRSVG 288
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767937598 287 KFPLILYLGMVIVTILYISLGCLGYLQFGANIQGSITLnlpncwLYQSVK----LLYSIGI----FFTYALQFYVPAEII 358
Cdd:PTZ00206 289 KFVLASTIAMGMCFTMYVLTAFFGYMDFGRNVTGSVLL------MYDPVNepaiMVGFVGVlvklFVSYALLGMACRNAL 362
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767937598 359 IPFFVSRAPE-----HCELVVDLFVrtvlVCLTCilAILIPRLDLVISLVGSVSSSALALIIPPLLEVTT--FYSEGMSP 431
Cdd:PTZ00206 363 YDVIGWDARKvafwkHCIAVVTLSV----VMLLC--GLFIPKINTVLGFAGSISGGLLGFILPALLFMYSggFTWQKVGP 436
                        410       420
                 ....*....|....*....|.
gi 767937598 432 LTIFKDALISILGFVGFVVGT 452
Cdd:PTZ00206 437 FYYISTYVVLITGVIAIVFGT 457
PotE COG0531
Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];
197-304 2.25e-04

Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];


Pssm-ID: 440297 [Multi-domain]  Cd Length: 438  Bit Score: 43.35  E-value: 2.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767937598 197 YMLSFLP---------FLVLLVFIRNLRALSIFSLLANITMLVSLVMIYQFIVQRIP--DPSHL-PLVAPWKTYPLFFGT 264
Cdd:COG0531  115 YLSSLFPaggsvlialVLILLLTLLNLRGVKESAKVNNILTVLKLLVLLLFIVVGLFafDPANFtPFLPAGGGLSGVLAA 194
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 767937598 265 ---AIFSFEGIGMVLPLENKMKDPRK-FPLILYLGMVIVTILYI 304
Cdd:COG0531  195 lalAFFAFTGFEAIANLAEEAKNPKRnIPRAIILSLLIVGVLYI 238
 
Name Accession Description Interval E-value
Aa_trans pfam01490
Transmembrane amino acid transporter protein; This transmembrane region is found in many amino ...
47-453 2.01e-68

Transmembrane amino acid transporter protein; This transmembrane region is found in many amino acid transporters including UNC-47 and MTR. UNC-47 encodes a vesicular amino butyric acid (GABA) transporter, (VGAT). UNC-47 is predicted to have 10 transmembrane domains. MTR is a N system amino acid transporter system protein involved in methyltryptophan resistance. Other members of this family include proline transporters and amino acid permeases.


Pssm-ID: 279788  Cd Length: 410  Bit Score: 224.11  E-value: 2.01e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767937598   47 TTWFQTLIHLLKGNIGTGLLGLPLAVKNAGIVMGPISLLIIGIVAVHCMGILVKCaHHFCRRLNKSFVDYGDTVmygles 126
Cdd:pfam01490   3 ISAWQAVFNLINAIIGAGVLSLPYAFKQLGWIPGLILLLIVGLISLYTAHLLVRC-SKEVPVTGKRNKSYGDLG------ 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767937598  127 spcswLRNHAHWGRRVVDFFLIVTQLGFCCVYFVFLADNFKQVIEaangttNNCHnnetvilTPTMDSRLYMLSFLPFLV 206
Cdd:pfam01490  76 -----YRLLGPKGRLLILFAILLNLFGVCISYLIFAGDNLPAIFD------SFFD-------TCPISLVYFIIIFGLIFI 137
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767937598  207 LLVFIRNLRALSIFSLLANITMLVSLVMIYQFIVQRIP-DPSHLPLVAPW-----KTYPLFFGTAIFSFEGIGMVLPLEN 280
Cdd:pfam01490 138 PLSFIPNLSALSILSLLAAVSSLYYIVILVLSVAEGIVlTAQGVGHLGSKtniklAGTFLAIGIIVFAFEGHAVLLPIQN 217
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767937598  281 KMKDPRKFPL---ILYLGMVIVTILYISLGCLGYLQFGANIQGSITLNLPN-CWLYQSVKLLYSIGIFFTYALQFYVPAE 356
Cdd:pfam01490 218 EMKNPSKFKAmtkILLTAIIIATVLYILIGLVGYLAFGDNVKGNILLNLPKsAWLIDIANLLLVLHVILSFPLQLFPIRQ 297
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767937598  357 II--------IPFFVSRAPEHCELVVDLFVRTVLVCLTCILAILIPRLDLVISLVGSVSSSALALIIPPLLEV----TTF 424
Cdd:pfam01490 298 IVenllfrkeAPFGASGKNNPKSKLLRVVIRSGLVVITYLIAISVPFFGDLLSLVGATSCAPLSFILPPLFHLklkkTKK 377
                         410       420
                  ....*....|....*....|....*....
gi 767937598  425 YSEGMSPLTIFKDALISILGFVGFVVGTY 453
Cdd:pfam01490 378 KSQEKLWKPDILDVICIVIGLLLMAYGVA 406
PTZ00206 PTZ00206
amino acid transporter; Provisional
61-452 1.55e-05

amino acid transporter; Provisional


Pssm-ID: 240313  Cd Length: 467  Bit Score: 47.17  E-value: 1.55e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767937598  61 IGTGLLGLPLAVKNAGIVMGPISLLIIGIVAVHCMGILVKCAHhfcrRLNKSFVDYGDTVMYGlesspcswlrnhaHWGR 140
Cdd:PTZ00206  74 VGAGIVGLPSAANSSGLVMAMIYLIIITAMTIFSIYALGVAAD----KTNIRTYEGVARVLLG-------------PWGS 136
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767937598 141 RVVDFFLIVTQLGFCCVYFVFLADNFKQVIEAANGTTNNCHNNETVILTPTMdsrlymlsFLPFLVLLVFIRNLRALSIF 220
Cdd:PTZ00206 137 YYVAATRAFHGFSACVAYVISVGDILSATLKGTNAPDFLKQKSGNRLLTSLM--------WLCFMLPLVIPRHIDSLRYV 208
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767937598 221 SLLANITML-VSLVMIYQFIVQRIPDPSHLPLVAPWKTYPLFF---------GTAIFSFEGIGMVLPLENKM----KDPR 286
Cdd:PTZ00206 209 STIAVSFMVyLVIVIVVHSCMNGLPENIKNVSVGKDDNAEIILfnsgnraieGLGVFIFAYVFQITAYEVYMdmtnRSVG 288
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767937598 287 KFPLILYLGMVIVTILYISLGCLGYLQFGANIQGSITLnlpncwLYQSVK----LLYSIGI----FFTYALQFYVPAEII 358
Cdd:PTZ00206 289 KFVLASTIAMGMCFTMYVLTAFFGYMDFGRNVTGSVLL------MYDPVNepaiMVGFVGVlvklFVSYALLGMACRNAL 362
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767937598 359 IPFFVSRAPE-----HCELVVDLFVrtvlVCLTCilAILIPRLDLVISLVGSVSSSALALIIPPLLEVTT--FYSEGMSP 431
Cdd:PTZ00206 363 YDVIGWDARKvafwkHCIAVVTLSV----VMLLC--GLFIPKINTVLGFAGSISGGLLGFILPALLFMYSggFTWQKVGP 436
                        410       420
                 ....*....|....*....|.
gi 767937598 432 LTIFKDALISILGFVGFVVGT 452
Cdd:PTZ00206 437 FYYISTYVVLITGVIAIVFGT 457
PotE COG0531
Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];
197-304 2.25e-04

Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];


Pssm-ID: 440297 [Multi-domain]  Cd Length: 438  Bit Score: 43.35  E-value: 2.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767937598 197 YMLSFLP---------FLVLLVFIRNLRALSIFSLLANITMLVSLVMIYQFIVQRIP--DPSHL-PLVAPWKTYPLFFGT 264
Cdd:COG0531  115 YLSSLFPaggsvlialVLILLLTLLNLRGVKESAKVNNILTVLKLLVLLLFIVVGLFafDPANFtPFLPAGGGLSGVLAA 194
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 767937598 265 ---AIFSFEGIGMVLPLENKMKDPRK-FPLILYLGMVIVTILYI 304
Cdd:COG0531  195 lalAFFAFTGFEAIANLAEEAKNPKRnIPRAIILSLLIVGVLYI 238
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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